Forces and tissue-specific mechanical properties of the microenvironment provide potent cues that are essential for regulating biological processes and maintaining normal functions in health and disease. Our group is studying how mechanobiological inputs direct cell-fate decision-making by integrating state-of-the-art single-cell genomics, microrheology, and deep learning AI. We focus on the mechanobiology of preimplantation embryo development, stem cell differentiation, inflammation, and nucleus mechanotransduction. Based on our research findings, we develop novel technologies and devices for improving medical treatment. Our interdisciplinary research is performed by students trained in Biology, Bioengineering, Physics and Computer Science who work closely with clinicians.