Yaakov Nahmias

 

Professor of Bioengineering

 

Office: 3-512 Silberman Institute (ASILS)

Phone: +972-2-5494640

E-mail: ynahmias@cse.huji.ac.il

 

Website: https://www.nahmias-lab.com

 

 

Degrees

 

B.Sc., Chemical Engineering, Technion, Israel Institute of Technology, 1999

Ph.D., Biomedical Engineering, University of Minnesota, 2004

Postdoc, Bioengineering, Harvard Medical School, 2006

 

Biography

 

Yaakov "Koby" Nahmias is an ERC-funded biomedical engineer and entrepreneur. He is the founding director of the Alexander Grass Center for Bioengineering at the Hebrew University of Jerusalem and the co-founder of the Israeli BioDesign program. Nahmias work is focused on the integration of tissue engineering, microfluidics, and metabolic regulation.

 

Selected Publications

 

Goggle Scholar: H-Index 30, Citation 3763

 OCRID: 0000-0002-6051-616X

 Complete List of Published Work in MyBibliography

 

1               Y. Nahmias, D. J. Odde, Micropatterning of living cells by laser-guided direct writing: application to fabrication of hepatic-endothelial sinusoid-like structures, Nature Protocols, 1(5):2288-2296(2006)

2               O. Benny, O. Fainaru, A. Adini, F. Cassiola, L. Bazinet, I. Adini, E. Pravda, Y. Nahmias, S. Koirala, G. Corfas, R. J. D'Amato, J. Folkman, An orally delivered small-molecule formulation with antiangiogenic and anticancer activity, Nature Biotechnology. 26(7):799-807 (2008)

3               S. Kidambi, R. Yarmush, E. Novik, P.B. Chao, M.L. Yarmush, Y. Nahmias, Oxygen-mediated enhancement of metabolism, functional polarization, gene expression, and drug clearance in co-cultures of primary hepatocytes, PNAS 106(37):15714-9 (2009)

4               B. Uygun, A. Soto-Gutierrez, H. Yagi, M.L. Izamis, M.A. Guzzardi, C. Shulman, J. Milwid, N. Kobayashi, A. Tilles, F. Berthiaume, M. Hertl, Y. Nahmias, M.L. Yarmush, K. Uygun. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nature Medicine. 16(7):814-20. (2010)

5               P. Koria, H. Yagi, Y. Kitagawa, Z. Megeed, Y. Nahmias, R. Sheridan, M.L. Yarmush, Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds. PNAS. 108(3):1034-9 (2011)

6               Y. Avior, G. Levy, M. Zimerman D. Kitsberg, R. Schwartz, R. Sadeh, A. Moussaieff, M. Cohen, J. Itskovitz-Eldor, Y. Nahmias. Microbial-Derived Lithocholic Acid and Vitamin K2 Drive the Metabolic Maturation of Pluripotent Stem Cells Derived Hepatocytes. Hepatology 2(1): 265-78. (2015)

7               A. Moussaieff, M. Rouleau, D. Kitsberg, M. Cohen, D. Barasch, A. Nemirovski, S.S. Shen-Orr, I. Laevsky, M. Amit, D. Bomze, B. Elena-Herrmann, T. Scherf, M. Nissim-Rafinia, S. Kempa, J. Itskovitz-Eldor E. Meshorer, D. Aberdam, Y. Nahmias. Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. Cell Metabolism 21(3): 392-402. (2015)

8               G. Levy, D. Bomze, S. Heinz, S.D. Ramachandran, A. Noerenberg, M. Cohen, O. Shibolet, E. Sklan, J. Braspenning, Y. Nahmias. Long-term culture and expansion of primary human hepatocytes. Nature Biotechnology 33(12): 1264-1271. (2015)

9               D. Bavli, S. Prill, E. Ezra, G. Levy, M. Cohen, M. Vinken, J. Vanfleteren, M. Jaeger, Y. Nahmias, Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction. PNAS 113(16):E2231-40. (2016)

10           G. Levy, M.A. Guzzardi, N. Habib, D. Kitsberg, D. Bomze, B.E. Uygun, K. Uygun, M. Trippler, J.F. Schlaak, O. Shibolet, E.H. Sklan, M. Cohen, J. Timm, N. Friedman, Y. Nahmias, Nuclear Receptors Control Pro- and Anti-Viral Metabolic Response to HCV Infection. Nature Chemical Biology 12, 1037–1045 (2016)