Gene Expression Analysis Methods
Computational analysis of DNA microarrays, focused on developing
statistical methods for detecting informative genes and machine
learning methods for clustering and classification. I take part in a
development team that writes and maintains ScoreGenes,
which is a toolkit for gene expression analysis. This toolkit is
free for academic use.
Applied Research in Gene Expression
Analysis of gene expression applied mainly to human diseases: Lung
Cancer, Asthma, PTSD, Muscular Dystrophy.
Inferring Transcription Regulation Networks from Large Scale Data
Automatic inference of transcription regulation networks from
large scale data such as gene expression and protein
interaction data, based on probabilistic graphical models. I
also take part in the development of libB
- Modeling and learning Bayesian networks.
Detecting Transcription Regulation in Asthma
Investigating the initiation of an asthmatic process following
stimuli in mice. Focus on transcription regulation detection,
using probabilistic graphical models. The results are
available on AsthmaMap
website (currently password-protected).
Publications
Journals
Mitochondrial processes are impaired in hereditary inclusion body myopathy. Eisenberg I, Novershtern N, Itzhaki Z, Becker-Cohen M, Sadeh M, Willems PH, Friedman N, Koopman WJ, Mitrani-Rosenbaum S.
Hum Mol Genet. 2008 Dec 1;17(23):3663-74.Abstractpdf
A Functional and Regulatory Map of Asthma Noa Novershtern, Zohar Itzhaki, Ohad Manor, Nir Friedman and Naftali KaminskiAmerican Journal of Respiratory Cell and Molecular Biology;2007
Abstract,
pdf
Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic
stress disorder among trauma survivors Ronnen Segman, Noa Novershtern, Tania Goltser-Dubner, Nir Friedman, Naftali Kaminski and Arik ShalevMolecular Psychiatry;2005;
pdf
Talks
Stochastic Integrative Modeling of Transcription Regulation Neural Information Processing Systems (NIPS) 2006; Computational Biology Meetingpdf
Novel Clues in the Pathophysiology of Hereditary Inclusion Body Myopathy Iris Eisenberg, Noa Shefi, Zohar Itshaki, Ron Dabby, W.J.H. Koopman, Menachem Sadeh and Stella Mitrani-Rosenbaum The 11th International Congress on Neuromusclar Diseases.
Gene expression patterns in blood cells classify post-traumatic stress disorder among trauma survivors Bertinoro Computational Biology Meeting 2003
