Our laboratory consists of interacting scientists that are interested in improving our basic understanding and manipulation of interactions between proteins, using a combination of computational and experimental approaches.

This embraces different levels of resolution and scale: starting from the basic atom - level details of interactions; continuing to prediction and characterization of specific interactions; and finally addressing the ultimate question of their role within the context of a cell and a whole organism.

Our computational tools include the structure-based computational prediction and manipulation of specific interactions using the Rosetta modeling framework, analysis of evolutionary signals hidden in sequences, and large-scale integration of this data by machine-learning approaches.

Our ERC starting grant has made it possible for us to realize a dream and to open a wet lab. Our experimental setup includes the characterization of interactions using biophysical methods such as ITC, as well as in vitro selection with Yeast surface Display. In addition, we have embarked on the journey of characterizing the functional role of proteins with repeated domains for the adaptability of yeast to environmental changes. Read More »

Positions available for PhD Students and PostDocs


(9/2017) PIPER-FlexPepDock is now online!

PIPER-FlexPepDock is a fragment-based protocol for high-resolution global peptide-protein docking.

Selected Publications

Check out our full publication list