Welcome!


Our laboratory consists of interacting scientists that are interested in improving our basic understanding and manipulation of interactions between proteins.

This embraces different levels of resolution and scale: starting from the basic atom - level details of interactions; continuing to prediction and characterization of specific interactions; and finally addressing the ultimate question of their role within the context of a cell and a whole organism.

We use computational tools, including structure-based computational prediction and manipulation of specific interactions, analysis of evolutionary signals hidden in sequences, and large-scale integration of this data by machine-learning approaches. Read More »

Positions available for PhD Students and PostDocs

News!


January 2013: We are starting our wet lab!


Shahar Rotem is our new Lab manager, and the first equipment has already arrived!


July 2012: Award of prestigious ERC starting grant!


Our lab is expanding! This grant allows us to open a wet lab that will complement our computational studies of peptide-mediated interactions.

April 2012: Ora has been promoted to Associate Professor!


Our principal investigator Ora Schueler-Furman is now an Associate Professor in the Department of Microbiology and Molecular Genetics.

August 2011: FlexPepDock is featured in Science!


You can view it here: http://www.sciencemag.org/content/333/6046/1164.short


Check out our recent papers:

Binding Specificity Prediction


London N, Gulla S, Keating A & Schueler-Furman O (2012).
In silico and in vitro elucidation of BH3 binding specificity towards Bcl-2. Biochemistry 51:5841-5850.

London, Lamphear, Hougland, Fierke & Schueler-Furman (2011).
Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity. PLoS Comput Biol 7:e1002170.

Al-Quadan, Price, London, Schueler-Furman & Abukwaik (2011).
Anchoring of bacterial effectors to host membranes through host-mediated lipidation by prenylation: a common paradigm. Trends Microbiol. 19:573-579.

FlexPepDock


London, Raveh, Cohen, Fathi & Schueler-Furman (2011).
Rosetta FlexPepDock web server--high resolution modeling of peptide-protein interactions.Nucleic Acids Res 39(Web Server issue):W249-53.


Raveh, London, Zimmerman & Schueler-Furman (2011).
Rosetta FlexPepDock ab-initio: Simultaneous Folding, Docking and Refinement of Peptides onto Their Receptors. PLoS One 6:e18934.


Belitsky, Avshalom, Erental, Yelin, Kumar, London, Sperber, Schueler-Furman & Engelberg-Kulka (2011).
The Escherichia coli extracellular death factor EDF induces the endoribonucleolytic activities of the toxins MazF and ChpBK. Mol Cell 41:625-35.


Headlines from the Macromolecular Modeling Blog: