Miniature robot-based precise targeting system for keyhole neurosurgery: concept and preliminary results L. Joskowicz (1), M. Shoham (2,3), R. Shamir (1), M. Freiman (1), E. Zehavi (3), Y. Shoshan (4) (1) School of Engineering and Computer Science, The Hebrew Univ. of Jerusalem, Israel. (2) Dept. of Mechanical Engineering, Technion, Haifa, Israel. (3) Mazor Surgical Technologies, Caesarea, Israel. (4) Dept. of Neurosurgery, School of Medicine, Hadassah University Hospital, Israel. Abstract: This paper describes a novel system for precise automatic targeting in minimally invasive neurosurgery. The system consists of a miniature robot fitted with a rigid mechanical guide for needle, catheter, or probe insertion. Intraoperatively, the robot is directly affixed to the patient skull or to a head clamp. It automatically positions itself with respect to predefined targets in a preoperative CT/MRI image following a three-way anatomical registration with an intraoperative 3D laser scan of the patient face features. We describe the system architecture, surgical protocol, software modules, and implementation. Registration results on 19 pairs of real MRI and 3D laser scan data show an RMS error of 1.0mm (std=0.95mm) in 2secs. Keywords: computer-aided neurosurgery, medical robotics, multimodal registration. Published in: 19th Int. Congress on Computer-Assisted Radiology and Surgery, CARS 2005, H.U. Lemke et. al. editors, Springer-Verlag, Berlin, Germany, June 2005, pp 618--623.