How to achieve fast, accurate, and robust rigid registration between fluoroscopic X-ray and CT images L. Joskowicz and D. Knaan School of Engineering and Computer Science, The Hebrew Univ. of Jerusalem, Israel. Abstract: This paper presents algorithmic refinements to our method for rigid registration between preoperative CT and intraoperative X-rays and studies the influence of various set-ups and factors on the methods' performance. Experimental results on five different anatomical structures show that the new three-phase algorithm achieves a mean accuracy of 0.7mm (max=1.1mm) 95\% of the time with an initial pose offset of up to 60mm in 80 secs average with three X-ray images and CT slice spacing of 2.4mm and handles image clutter well. Keywords: 2D/3D rigid registration, intensity-based registration Published in: Proc. of the 18th Int. Congress on Computer-Assisted Radiology and Surgery, CARS'2004, H.U. Lemke et. al. editors, International Congress Series Elsevier 2004, pp 147--152.