Comparative in-vitro study of contact and image-based rigid registration for computer-aided surgery Ofri Sadowsky, Ziv Yaniv, and Leo Joskowicz School of Computer Science and Engineering The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Abstract: We present an in-vitro study of rigid registration methods for computer-aided surgery. The goal of the study is to empirically obtain accuracy measures under optimal laboratory conditions and to identify the weak links in the registration chain. Specifically, we investigate two common registration methods: contact-based registration and image-based landmark registration. We establish a framework for comparing the accuracy of both methods and describe phantoms, protocols, and algorithms for tool tip calibration, contact-based registration with an optical tracker, fluoroscopic X-ray camera calibration, and fluoroscopic X-ray image-based landmark registration. We report an average accuracy of 0.5mm (1.5mm maximum) and 2.75mm (3.4mm maximum) for contact-based and image-based landmark registration, respectively. Based on our findings, we identify the camera calibration as being the main source of error in image-based landmark registration. We propose protocol improvements and algorithmic refinements to improve the accuracy of image-basedr landmark registration. Keywords: registration, image-based registration, contact-based registration, accuracy measurements, fluoroscopy, tracking. Published in: Computer-Aided Surger, Vol. 7(4), 2002, pp. 223-236.