Femur mechanical simulation using higher-order finite-element analysis with continuous mechanical properties R. Fedida (1), Z. Yosibach (1), C. Milgrom (2), and L. Joskowicz (3) Abstract: Femur 3D finite-element (FE) analysis based on CT data requires both accurate geometry representation and mechanical properties assignment. A "structure based" method is suggested for the reconstruction of a FE model so that the geometry is represented by smooth surfaces extracted from the CT data including a separating surface between cortical and trabecular regions. Then, p-FE automesh is generated. Within each region (cortical or trabecular), the heterogeneous density is described by continuous spatial functions that are generated using Least Squares Minimum (LST) approximations based on the Ct data scan. Finally, the Young modulusi9s evaluated continuously according to teh functional representation of the density. Numerical investigation shows good results of the suggested method compared to the voxel-based method. Mechanical in-vitro experiments on fresh frozen femur measuring head deflection and strains at several points is currently used for FE model calibration and validation. Keywords: FEA, femur modeling, stress analysis Published in: Proc. 2nd Int. Conf. on Computational Bioengineering, Lisbon, Portugal. Rodrigues H. et al. editors, IST press, Volume 1, pp.85-96, September 2005.