Detection and correction of volumetric medical image segmentation errors by 3D-ray casting and Laplace deformation

Abstract Purpose Patient-specific models of anatomical structures and pathologies generated from volumetric medical images play an increasingly central role in many aspects of patient care. A key task in generating these models is the segmentation of anatomical structures and pathologies of interest. Although numerous…

Tumor burden evaluation in NF1 patients with plexiform neurofibromas in daily clinical practice

Abstract Background Existing volumetric measurements of plexiform neurofibromas (PNs) are time consuming and error prone, as they require delineation of PN boundaries, a procedure that is not practical in the typical clinical setting. The aim of this study is to…

Haptic computer-assisted patient-specific preoperative planning for orthopedic fractures surgery

Abstract Purpose The aim of orthopedic trauma surgery is to restore the anatomy and function of displaced bone fragments to support osteosynthesis. For complex cases, including pelvic bone and multi-fragment femoral neck and distal radius fractures, preoperative planning with a…

Automatic lung tumor segmentation with leaks removal in follow-up CT studies

Abstract Purpose In modern oncology, disease progression and response to treatment are routinely evaluated with a series of volumetric scans. The number of tumors and their volume (mass) over time provides a quantitative measure for the evaluation. Thus, many of…

Snellen and ETDRS Charts Compared Using a Computer Simulation

Abstract Aim: To compare accuracy, reproducibility and test duration for the Snellen and the Early Treatment of Diabetic Retinopathy Study (ETDRS) charts, two main tools used to measure visual acuity (VA). Methods: A computer simulation was programmed to run multiple…

The Effect of Chemotherapy on Optic Pathway Gliomas and Their Sub-Components: A Volumetric MR Analysis Study

Abstract Background. Optic pathway gliomas (OPG) represent 5% of pediatric brain tumors and compose a major therapeutic dilemma to the treating physicians. While chemotherapy is widely used for these tumors, our ability to predict radiological response is still lacking. In…

The role of automatic computer-aided surgical trajectory planning in improving the expected safety of stereotactic neurosurgery

Abstract Purpose Minimal invasion computer-assisted neurosurgical procedures with various tool insertions into the brain may carry hemorrhagic risks and neurological deficits. The goal of this study is to investigate the role of computer-based surgical trajectory planning tools in improving the…

Validation of a stereo camera system to quantify brain deformation due to breathing and pulsatility

Abstract Purpose: A new stereo vision system is presented to quantify brain shift and pulsatility in open-skull neurosurgeries. Methods: The system is endowed with hardware and software synchronous image acquisition with timestamp embedding in the captured images, a brain surface…

Coronal tibiofemoral subluxation: a new measurement method

Abstract Background: Coronal tibiofemoral (CTF) subluxation is a common finding in knee osteoarthritis (OA) which can be related to poor pain scores and tibial spine impingement. In this study we describe a new method for measuring CTF subluxation and present…

Semiautomatic segmentation and follow-up of multicomponent low-grade tumors in longitudinal brain MRI studies

Abstract Purpose: Tracking the progression of low grade tumors (LGTs) is a challenging task, due to their slow growth rate and associated complex internal tumor components, such as heterogeneous enhancement, hemorrhage, and cysts. In this paper, the authors show a…

PNist: interactive volumetric measurements of plexiform neurofibromas in MRI scans

Abstract Purpose Volumetric measurements of plexiform neurofibromas (PNs) are time consuming and error prone, as they require the delineation of the PN boundaries, which is mostly impractical in the daily clinical setup. Accurate volumetric measurements are seldom performed for these…

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