VV TRANSFAC GENE TABLE, Release 6.2 - licensed - 2002-07-01, (C) Biobase GmbH XX // AC G000001 XX ID AAV$P5 XX DT 14.06.1995 (created); dbo. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD P5 XX OS AAV, adeno-associated virus OC viridae; ss-DNA nonenveloped viruses; parvoviridae; dependovirus XX BC 6.3.6 XX BS -60 0 R03174; AAV$P5_01; Binding factors: YY1 . BS -50 0 R03176; AAV$P5_03; Binding factors: factor 2 , BS 96K-protein . BS 1 0 R03175; AAV$P5_02; Binding factors: YY1 . XX DR EMBL: J01901; XX2. DR TRANSPATH: G000001. XX RN [1] RX MEDLINE; 94019335. RA Satyamoorthy K., Park K., Atchison M. L., Howe C. C. RT The intracisternal A-particle upstream element interacts with transcription RT factor YY1 to activate transcription: pleiotropic effects of YY1 on RT distinct DNA promoter elements RL Mol. Cell. Biol. 13:6621-6628 (1993). RN [2] RX MEDLINE; 92005716. RA Shi Y., Seto E., Chang L.-S., Shenk T. RT Transcriptional repression by YY1, a human GLI-Krueppel-related protein, RT and relief of repression by adenovirus E1A protein RL Cell 67:377-388 (1991). XX // AC G000003 XX ID AD5$E1A XX DT 14.06.1995 (created); dbo. DT 11.12.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD E1A XX DE early gene 1A XX OS adenovirus type 5 OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX BC 6.3.3.2 XX BS -498 -458 R01988; AD5$E1A_12; Binding factors: NF-1 . BS -464 -452 R01989; AD5$E1A_13; Binding factors: POU2F1 . BS -450 -428 R01990; AD5$E1A_14; Binding factors: ATF . BS -420 -391 R01991; AD5$E1A_15; Binding factors: Sp1 . BS -414 -391 R01992; AD5$E1A_16; Binding factors: ATF . BS -394 -375 R01993; AD5$E1A_17; Binding factors: PEA3 . BS -384 -363 R01994; AD5$E1A_18. BS -346 -334 R01995; AD5$E1A_19; Binding factors: PEA3 . BS -338 -319 R01997; AD5$E1A_21; Binding factors: ATF . BS -319 -305 R01998; AD5$E1A_22. BS -304 -289 R01999; AD5$E1A_23; Binding factors: GABP , PEA3 BS , GABP-alpha . BS -291 -278 R00310; AD5$E1A_04; Binding factors: E2F . BS -273 -257 R01996; AD5$E1A_20; Binding factors: GABP , PEA3 BS , GABP-alpha . BS -228 -214 R00311; AD5$E1A_05; Binding factors: E2F , E2F+E4 BS . BS -197 -181 R02001; AD5$E1A_25; Binding factors: POU2F1 . BS -178 -165 R02002; AD5$E1A_26. BS -99 -91 R02003; AD5$E1A_27. BS -83 -36 R02004; AD5$E1A_28. BS -72 -45 R02005; AD5$E1A_29. BS -52 -21 R00309; AD5$E1A_03; Binding factors: CREB . BS -38 -21 R02006; AD5$E1A_30. BS -25 34 R02007; AD5$E1A_31. BS -12 9 R02008; AD5$E1A_32. XX DR EMBL: X02996; AD5001. DR TRANSPATH: G000003. XX RN [1] RX MEDLINE; 93140781. RA Chen S., West R. W., Johnson S. L., Gans H., Kruger B., Ma J. RT TSF3, a global regulatory protein that silences transcription of yeast GAL RT genes, also mediates repression by alpha2 repressor and is identical to SIN4 RL Mol. Cell. Biol. 13:831-840 (1993). RN [2] RX MEDLINE; 93126097. RA Bolwig G. M., Bruder J. T., Hearing P. RT Different binding site requirements for binding and activation for the RT bipartite enhancer factor EF-1A RL Nucleic Acids Res. 20:6555-6564 (1992). RN [3] RX MEDLINE; 89378737. RA Hardy S., Engel D. A., Shenk T. RT An adenovirus early region 4 gene product is required for induction of the RT infection-specific form of cellular E2F activity RL Genes Dev. 3:1062-1074 (1989). RN [4] RX MEDLINE; 90097931. RA Bruder J. T., Hearing P. RT Nuclear Factor EF-1A Binds to the Adenovirus E1A Core Enhancer Element and RT to Other Transcriptional Control Regions RL Mol. Cell. Biol. 9:5143-5153 (1989). RN [5] RX MEDLINE; 90066460. RA Hardy S., Shenk T. RT E2F from Adenovirus-Infected Cells Binds Cooperatively to DNA Containing RT Two Properly Oriented and Spaced Recognition Sites RL Mol. Cell. Biol. 9:4495-4506 (1989). RN [6] RX MEDLINE; 90098767. RA Yoshida K., Narita M., Fujinaga K. RT Binding sites of HeLa cell nuclear proteins on the upstream region of RT adenovirus type 5 E1A gene RL Nucleic Acids Res. 17:10015-10034 (1989). RN [7] RX MEDLINE; 88247984. RA Hardy S., Shenk T. RT Adenoviral control regions activated by E1A and the cAMP responsive element RT bind to the same factor RL Proc. Natl. Acad. Sci. USA 85:4171-4175 (1988). RN [8] RX MEDLINE; 87175637. RA Kovesdi I., Reichel R., Nevins J. R. RT Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate RT gene control RL Proc. Natl. Acad. Sci. USA 84:2180-2184 (1987). XX // AC G000004 XX ID AD2$E1B XX DT 14.06.1995 (created); dbo. DT 11.12.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD E1B XX DE early gene 1B XX OS adenovirus type 2 OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX BC 6.3.3.2 XX BS empty empty R03346; AD2$E1B_05. BS -245 0 R01765; AD2$E1B_01; Binding factors: Sp1 . BS -52 -18 R01764; AD2$E1B_02; Binding factors: Sp1 , TBP BS , TFIID . BS -45 -35 R00315; AD2$E1B_03; Binding factors: MAZ , Sp1 BS , Sp1 , BTEB1 . BS -33 -18 R01732; AD2$E1B_04; Binding factors: TBP , TBP BS . XX DR EMBL: X02996; AD5001. DR EMBL: J01917; HACG. DR TRANSPATH: G000004. XX RN [1] RX MEDLINE; 96224025. RA Parks C. L., Shenk T. RT The serotonin 1a receptor gene contains a TATA-less promoter that responds RT to MAZ and Sp1 RL J. Biol. Chem. 271:4417-4430 (1996). RN [2] RX MEDLINE; 94103188. RA Sogawa K., Kikuchi Y., Imataka H., Fujii-Kuriyama Y. RT Comparison of DNA-binding properties between BTEB and Sp1 RL J. Biochem. 114:605-609 (1993). RN [3] RX MEDLINE; 93012951. RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J. RT Holo-TFIID supports transcriptional stimulation by diverse activators and RT from a TATA-less promoter RL Genes Dev. 6:1964-1974 (1992). RN [4] RX MEDLINE; 91094880. RA Lieberman P. M., Schmidt M. C., Kao C. C., Berk A. J. RT Two distinct domains in the yeast transcription factor IID and evidence for RT a TATA box-induced conformational change RL Mol. Cell. Biol. 11:63-74 (1991). RN [5] RX MEDLINE; 91319707. RA Spergel J. M., Chen-Kiang S. RT Interleukin 6 enhances a cellular activity that functionally substitutes RT for E1A protein in transactivation RL Proc. Natl. Acad. Sci. USA 88:6472-6476 (1991). RN [6] RX MEDLINE; 90302010. RA Kao C. C., Liebermann P. M., Schmidt M. C., Zhou Q., Pei R., Berk A. J. RT Cloning of a transcriptionally active human TATA binding factor RL Science 248:1646-1650 (1990). RN [7] RX MEDLINE; 90014783. RA Schmidt M. C., Zhou Q., Berk A. J. RT Sp1 Activates Transcription without Enhancing DNA-Binding Activity of the RT TATA Box Factor RL Mol. Cell. Biol. 9:3299-3307 (1989). RN [8] RX MEDLINE; 90046680. RA Schmidt M. C., Kao C. C., Pei R., Berk A. J. RT Yeast TATA-box transcription factor gene RL Proc. Natl. Acad. Sci. USA 86:7785-7789 (1989). RN [9] RX MEDLINE; 87173017. RA Wu L., Rosser D. S. E., Schmidt M. C., Berk A. J. RT A TATA box implicated in E1A transcriptional activation of a simple RT adenovirus 2 promoter RL Nature 326:512-515 (1987). XX // AC G000005 XX ID AD$E2AE1 XX DT 14.06.1995 (created); dbo. DT 16.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD EIIaE1 XX DE E2-early promoter XX OS adenovirus OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX BC 6.3.3.2 XX BS -155 -128 R00316; AD$E2AE1_01. BS -142 -129 R00317; AD$E2AE1_02; Binding factors: EIIaE-Calpha . BS -127 -112 R00318; AD$E2AE1_03; Binding factors: EIIaE-Cbeta . BS -105 -88 R00319; AD$E2AE1_04. BS -96 -61 R00320; AD$E2AE1_05. BS -94 10 R03467; AD$E2AE1_22; Binding factors: DRTF1 , TF68 BS , EC5 . BS -94 10 R03468; AD$E2AE1_23; Binding factors: EC5 , PCRE1 BS . BS -86 -73 R02686; AD$E2AE1_19; Binding factors: TF68 . BS -84 -68 R00321; AD$E2AE1_06. BS -83 -69 R00322; AD$E2AE1_07; Binding factors: ATF , ATF-a BS , CREB , CREB , 47-kDa CRE bind. prot. . BS -82 -66 R00323; AD$E2AE1_08; Binding factors: EIIaE-B . BS -82 -64 R00324; AD$E2AE1_10; Binding factors: EIIaE-B . BS -74 -33 R00325; AD$E2AE1_11. BS -73 -61 R02687; AD$E2AE1_20; Binding factors: DRTF1 . BS -73 -30 R03879; AD$E2AE1_24; Binding factors: E2F , E4 BS . BS -71 -53 R00326; AD$E2AE1_12; Binding factors: DRTF1 , E2F BS , E2F+E4 , pRb , pRb , RBP60 , BS RBP60 , E2F-1 . BS -60 -51 R02688; AD$E2AE1_21; Binding factors: DRTF2 , TBP BS , TBP . BS -59 -36 R00327; AD$E2AE1_13; Binding factors: EIIaE-A . BS -50 -32 R00328; AD$E2AE1_14. BS -49 -35 R00329; AD$E2AE1_15; Binding factors: E2F , E2F+E4 BS , spE2F , E2F-1 . BS -48 -33 R00330; AD$E2AE1_16; Binding factors: E2F . BS -36 -19 R00331; AD$E2AE1_17. BS -36 -4 R00332; AD$E2AE1_18. XX DR EMBL: X02996; AD5001. DR EMBL: M13157; ADEE2PRO. DR EMBL: J01917; HACG. DR TRANSPATH: G000005. DR TRANSCOMPEL: C00193. XX RN [1] RX MEDLINE; 93388615. RA Malhotra P., Manohar C. F., Swaminathan S., Toyama R., Dhar R., Reichel R., RA Thimmapaya B. RT E2F site activates transcription in fission yeast Schizosaccharomyces pombe RT and binds to a 30-kDa transcription factor RL J. Biol. Chem. 268:20392-20401 (1993). RN [2] RX MEDLINE; 93324341. RA Swaminathan S., Malhotra P., Manohar C. F., Dhar R., Thimmapaya B. RT Activation of a dual adenovirus promoter containing nonconsensus TATA RT motifs in Schizosaccharomyces pombe: role of TATA sequences in the RT efficiency of transcription RL Nucleic Acids Res. 21:2737-2746 (1993). RN [3] RX MEDLINE; 93024374. RA Ray S. K., Arroyo M., Bagchi S., Raychaudhuri P. RT Identification of a 60-Kilodalton Rb-binding protein, RBP60, that allows RT the Rb-E2F complex to bind DNA RL Mol. Cell. Biol. 12:4327-4333 (1992). RN [4] RX MEDLINE; 92017833. RA Murray E. J., Stott D., Rigby P. W. J. RT Sequences and factors required for the F9 embryonal carcinoma stem cell RT E1a-like activity RL Mol. Cell. Biol. 11:5534-5540 (1991). RN [5] RX MEDLINE; 91141520. RA Shivji M. K. K., La Thangue N. B. RT Multicomponent differentiation-regulated transcription factors in F9 RT embryonal carcinoma stem cells RL Mol. Cell. Biol. 11:1686-1695 (1991). RN [6] RX MEDLINE; 92093621. RA O'Connor R. J., Hearing P. RT The C-terminal 70 amino acids of the adenovirus E4-ORF6/7 protein are RT essential and sufficient for E2F complex formation RL Nucleic Acids Res. 19:6579-6586 (1991). RN [7] RX MEDLINE; 91319707. RA Spergel J. M., Chen-Kiang S. RT Interleukin 6 enhances a cellular activity that functionally substitutes RT for E1A protein in transactivation RL Proc. Natl. Acad. Sci. USA 88:6472-6476 (1991). RN [8] RX MEDLINE; 92037545. RA Partridge J. F., La Thangue N. B. RT A developmentally regulated and tissue-dependent transcription factor RT complexes with the retinoblastoma gene product RL EMBO J. 10:3819-3827 (1991). RN [9] RX MEDLINE; 90272397. RA La Thangue N. B., Thimmappaya B., Rigby P. W. J. RT The embryonal carcinoma stem cell E1a-like activity involves a RT differentiation-regulated transcription factor RL Nucleic Acids Res. 18:2929-2938 (1990). RN [10] RX MEDLINE; 90175381. RA Boeuf H., Reimund B., Jansen-Duerr P., Kedinger C. RT Differential activation of the E2F transcription factor by the adenovirus RT EIa and EIV products in F9 cells RL Proc. Natl. Acad. Sci. USA 87:1782-1786 (1990). RN [11] RX MEDLINE; 90175426. RA Neill S. D., Hemstrom C., Virtanen A., Nevins J. R. RT An adenovirus E4 gene product trans-activates E2 transcription and RT stimulates stable E2F binding through a direct association with E2F RL Proc. Natl. Acad. Sci. USA 87:2008-2012 (1990). RN [12] RX MEDLINE; 90291982. RA Mudryj M., Hiebert S. W., Nevins J. R. RT A role for the adenovirus inducible E2F transcription factor in a RT proliferation dependent signal transduction pathway RL EMBO J. 9:2179-2184 (1990). RN [13] RX MEDLINE; 90301459. RA Gaire M., Chatton B., Kedinger C. RT Isolation and characterization of two novel, closely related ATF cDNA RT clones from HeLa cells RL Nucleic Acids Res. 18:3467-3473 (1990). RN [14] RX MEDLINE; 90059930. RA Jansen-Duerr P., Boeuf H., Kedinger C. RT Cooperative binding of two E2F molecules to an E1a-responsive promoter is RT triggered by the adenovirus E1a, but not by a cellular E1a-like activity RL EMBO J. 8:3365-3370 (1989). RN [15] RX MEDLINE; 90108666. RA Huang M.-M., Hering P. RT The adenovirus early 4 open reading frame 6/7 protein regulates the DNA RT binding activity of the cellular transcription factor, E2F, through a RT direct complex RL Genes Dev. 3:1699-1710 (1989). RN [16] RX MEDLINE; 89378737. RA Hardy S., Engel D. A., Shenk T. RT An adenovirus early region 4 gene product is required for induction of the RT infection-specific form of cellular E2F activity RL Genes Dev. 3:1062-1074 (1989). RN [17] RX MEDLINE; 89197969. RA Loeken M. R., Brady J. RT The Adenovirus EIIA Enhancer RL J. Biol. Chem. 264:6572-6579 (1989). RN [18] RX MEDLINE; 89214111. RA Kwast-Welfeld J., Soong C.-J., Short M. L., Jungmann R. A. RT Identification of Rat Ovarian Nuclear Factors That Interact with the RT cAMP-inducible Lactate Dehydrogenase A Subunit Promoter RL J. Biol. Chem. 264:6941-6947 (1989). RN [19] RX MEDLINE; 89219051. RA Yee A. S., Raychaudhuri P., Jakoi L., Nevins J. R. RT The Adenovirus-Inducible Factor E2F Stimulates Transcription after Specific RT DNA Binding RL Mol. Cell. Biol. 9:578-585 (1989). RN [20] RX MEDLINE; 90066460. RA Hardy S., Shenk T. RT E2F from Adenovirus-Infected Cells Binds Cooperatively to DNA Containing RT Two Properly Oriented and Spaced Recognition Sites RL Mol. Cell. Biol. 9:4495-4506 (1989). RN [21] RX MEDLINE; 89264470. RA Hiebert S. W., Lipp M., Nevins J. R. RT E1A-dependent trans-activation of the human MYC promoter is mediated by the RT E2F factor RL Proc. Natl. Acad. Sci. USA 86:3594-3598 (1989). RN [22] RX MEDLINE; 88247984. RA Hardy S., Shenk T. RT Adenoviral control regions activated by E1A and the cAMP responsive element RT bind to the same factor RL Proc. Natl. Acad. Sci. USA 85:4171-4175 (1988). RN [23] RX MEDLINE; 88190096. RA Jalinot P., Wintzerith M., Gaire M., Hauss C., Egly J. M., Kedinger C. RT Purification and functional characterization of a cellular transcription RT factor that binds to an enhancer element within the adenovirus early EIIa RT promoter RL Proc. Natl. Acad. Sci. USA 85:2484-2488 (1988). RN [24] RX MEDLINE; 87187648. RA La Thangue N. B., Rigby P. W. RT An Adenovirus E1A-like Transcription Factor Is Regulated during the RT Differentiation of Murine Embryonal Carcinoma Cells RL Cell 49:507-513 (1987). RN [25] RX MEDLINE; 88004418. RA Yee A. S., Reichel R., Kovesdi I., Nevins J. R. RT Promoter interaction of the E1A-inducible factor E2F and its potential role RT in the formation of a multi-component complex RL EMBO J. 6:2061-2068 (1987). RN [26] RX MEDLINE; 88142851. RA Devaux B., Albrecht G., Kedinger C. RT Identical Genomic Footprints of the Adenovirus EIIa Promoter Are Detected RT before and after EIa Induction RL Mol. Cell. Biol. 7:4560-4563 (1987). RN [27] RX MEDLINE; 88065522. RA Jalinot P., Devaux B., Kedinger C. RT The Abundance and In Vitro DNA Binding of Three Cellular Proteins RT Interacting with the Adenovirus EIIa Early Promoter Are Not Modified by the RT EIa Gene Products RL Mol. Cell. Biol. 7:3806-3817 (1987). RN [28] RX MEDLINE; 87146375. RA Boeuf H., Zajchowski D., Tamura T., Hauss C., Kedinger C. RT Specific cellular proteins bind to critical promoter sequences if the RT adenovirus early EIIa promoter RL Nucleic Acids Res. 15:509-527 (1987). RN [29] RX MEDLINE; 87317605. RA SivaRaman L., Thimmappaya B. RT Two promoter-specific host factors interact with adjacent sequences in an RT EIA-inducible adenovirus promoter RL Proc. Natl. Acad. Sci. USA 84:6112-6116 (1987). RN [30] RX MEDLINE; 86287364. RA SivaRaman L., Subramanian S., Thimmappaya B. RT Identification of a factor in HeLa cells specific for an upstream RT transcriptional control sequence of an EIA-inducible adenovirus promoter RT and its relative abundance in infected and uninfected cells RL Proc. Natl. Acad. Sci. USA 83:5914-5918 (1986). RN [31] RX MEDLINE; 86122886. RA Kovesdi I., Reichel R., Nevins J. R. RT E1A Transcription Induction: Enhanced Binding of a Factor to Upstream RT Promoter Sequences RL Science 231:719-722 (1986). XX // AC G000006 XX ID AD2$E2L XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD E2L XX DE E2-late promoter XX OS adenovirus type 2 OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX BC 6.3.3 XX BS -250 -228 R00333; AD2$E2L_01; Binding factors: CRF , G6 factor BS . BS -213 -186 R00334; AD2$E2L_02; Binding factors: G6 factor . BS -155 -128 R00335; AD2$E2L_03; Binding factors: CRF . BS -125 -97 R00336; AD2$E2L_04; Binding factors: USF2 , USF2 BS , USF2b . BS -90 -65 R00337; AD2$E2L_05; Binding factors: CRF , Sp1 BS . BS -56 -36 R00338; AD2$E2L_06; Binding factors: Sp1 . XX DR EMBL: J01917; HACG. DR TRANSPATH: G000006. XX RN [1] RX MEDLINE; 88040407. RA Goding C. R., Temperley S. M., Fisher F. RT Multiple transcription factors interact with the adenovirus-2 EII-late RT promoter: evidence for a new CCAAT recognition factor RL Nucleic Acids Res. 15:7761-7780 (1987). XX // AC G000007 XX ID AD$E3 XX DT 14.06.1995 (created); dbo. DT 16.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD E3 XX DE early gene 3 XX OS adenovirus OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX BC 6.3.3.2 XX BS -179 -160 R00339; AD$E3_01. BS -179 -156 R00340; AD$E3_02; Binding factors: CTF , NF-1 BS . BS -155 -137 R02913; AD$E3_09; Binding factors: NF-kappaB(-like) . BS -134 -113 R02914; AD$E3_10; Binding factors: NF-kappaB(-like) . BS -103 -83 R00341; AD$E3_03; Binding factors: AP-1 . BS -103 -74 R00342; AD$E3_04. BS -70 -42 R00343; AD$E3_05; Binding factors: AP-1 , ATF BS , ATF-like , CREB , CRE-BP1 , E4F1 BS , ATF-1 . BS -37 -16 R00344; AD$E3_06; Binding factors: TFIID . BS -37 -6 R00346; AD$E3_08. BS -35 0 R00345; AD$E3_07; Binding factors: AP-1 . XX DR EMBL: X03002; AD5E3. DR EMBL: J01917; HACG. DR TRANSPATH: G000007. XX RN [1] RX MEDLINE; 91342628. RA Jones C., Lee K. A. W. RT E1A-mediated activation of the adenovirus E4 promoter can occur RT independently of the cellular transcription factor E4F RL Mol. Cell. Biol. 11:4297-4305 (1991). RN [2] RX MEDLINE; 91092268. RA Williams J. L., Garcia J., Harrich D., Pearson L., Wu F., Gaynor R. RT Lymphoid specific gene expression of the adenovirus early region 3 promoter RT is mediated by NF-kappaB binding motifs RL EMBO J. 9:4435-4442 (1990). RN [3] RX MEDLINE; 90076146. RA Buckbinder L., Miralles V. J., Reinberg D. RT TPA can overcome the requirement for EIa and together can act RT synergistically in stimulating expression of the adenovirus EIII promoter RL EMBO J. 8:4239-4250 (1989). RN [4] RX MEDLINE; 90078230. RA Merino A., Buckbinder L., Mermelstein F. H., Reinberg D. RT Phosphorylation of cellular proteins regulates their binding to the cAMP RT response element RL J. Biol. Chem. 264:21266-21276 (1989). RN [5] RX MEDLINE; 89315196. RA Richter J. D. RT In vivo photocrosslinking reveals that transcription factor binding to the RT mammalian ATF recognition sequence is required for E1A-induced RT transactivation in injected Xenopus laevis oocytes RL Nucleic Acids Res. 17:4503-4516 (1989). RN [6] RX MEDLINE; 89127211. RA Kornuc M., Altman R., Harrich D., Garcia J., Chao J., Kayne P., Gaynor R. RT Adenovirus transcriptional regulatory regions are conserved in mammalian RT cells and Saccharomycer cerevisiae RL Mol. Cell. Biol. 8:3717-3725 (1988). RN [7] RX MEDLINE; 88261270. RA Andrisani O. M., Pot D. A., Zhu Z., Dixon J. E. RT Three Sequence-Specific DNA-Protein Complexes Are Formed with the Same RT Promoter Element Essential for Expression of the Rat Somatostatin Gene RL Mol. Cell. Biol. 8:1947-1956 (1988). RN [8] RX MEDLINE; 88247984. RA Hardy S., Shenk T. RT Adenoviral control regions activated by E1A and the cAMP responsive element RT bind to the same factor RL Proc. Natl. Acad. Sci. USA 85:4171-4175 (1988). RN [9] RX MEDLINE; 88040461. RA Garcia J., Wu F., Gaynor R. RT Upstream regulatory regions required to stabilize binding to the TATA RT sequence in an adenovirus early promoter RL Nucleic Acids Res. 15:8367-8385 (1987). XX // AC G000008 XX ID AD$E4 XX DT 14.06.1995 (created); dbo. DT 16.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD E4 XX DE early gene 4 XX OS adenovirus OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX BC 6.3.3.2 XX BS -306 -281 R00347; AD$E4_01; Binding factors: NF-1 . BS -267 -247 R00348; AD$E4_02; Binding factors: E4F1 . BS -239 -215 R00349; AD$E4_03; Binding factors: CRE-BP1 , E4F1 BS . BS -200 0 R00350; AD$E4_04; Binding factors: ATF . BS -174 -150 R00351; AD$E4_05; Binding factors: E4F1 . BS -173 -145 R00353; AD$E4_07. BS -172 -135 R00354; AD$E4_08; Binding factors: E4F1 . BS -170 -163 R00355; AD$E4_09; Binding factors: E4F . BS -169 -162 R00352; AD$E4_06; Binding factors: atf1 , ATF BS , c-Jun , deltaCREB , CRE-BP1 , E4BP4 BS . BS -167 -138 R00356; AD$E4_10; Binding factors: CREB , CRE-BP1 BS , CRE-BP2 . BS -152 -132 R00357; AD$E4_11; Binding factors: GABP , GABP-alpha BS , GABP-beta1 , GABP-beta2 . BS -145 -138 R02403; AD$E4_23; Binding factors: ATF . BS -118 -94 R00358; AD$E4_12; Binding factors: E4TF2 . BS -100 0 R00359; AD$E4_13; Binding factors: ATF , TREB-1 BS . BS -80 0 R00360; AD$E4_14; Binding factors: ATF , TFIID BS , TREB-1 . BS -76 -18 R03153; AD$E4_24; Binding factors: C/EBPalpha . BS -74 -39 R00361; AD$E4_15; Binding factors: CAP . BS -61 -38 R03430; AD$E4_25; Binding factors: ATF . BS -58 -40 R00362; AD$E4_16; Binding factors: ATF , atf1 BS , ATF , c-Jun , CREB , CREB , BS deltaCREB , CRE-BP1 , TREB-1 , EivF , ATF3 BS . BS -56 -39 R00363; AD$E4_17; Binding factors: E4F1 . BS -54 -33 R00364; AD$E4_18; Binding factors: E4F1 . BS -53 -46 R00365; AD$E4_19; Binding factors: E4F . BS -45 0 R00366; AD$E4_20; Binding factors: CREB . BS -30 0 R00367; AD$E4_21; Binding factors: TBP , TBP , BS TFIID . BS 7 13 R00368; AD$E4_22; Binding factors: AP-1 . XX DR EMBL: X02998; AD5004. DR EMBL: J01917; HACG. DR TRANSPATH: G000008. DR TRRD: 00058. XX RN [1] RX MEDLINE; 96134918. RA Takeda T., Toda T., Kominami K., Kohnosu A., Yanagida M., Jones N. RT Schizosaccharomyces pombe atf1+ encodes a transcription factor required for RT sexual development and entry into stationary phase RL EMBO J. 14:6193-6208 (1995). RN [2] RX MEDLINE; 94185646. RA Sawada J.-I., Goto M., Sawa C., Watanabe H., Handa H. RT Transcriptional activation through the tetrameric complex formation of RT E4TF1 subunits RL EMBO J. 13:1396-1402 (1994). RN [3] RX MEDLINE; 94248047. RA Benbrook D. M., Jones N. C. RT Different binding specificities and transactivation of variant CRE's by RT CREB complexes RL Nucleic Acids Res. 22:1463-1469 (1994). RN [4] RX MEDLINE; 93180783. RA Watanabe H., Sawada J.-I., Yano K.-I., Yamaguchi K., Goto M., Handa H. RT cDNA cloning of transcription factor E4TF1 subunits with Ets and Notch RT motifs RL Mol. Cell. Biol. 13:1385-1391 (1993). RN [5] RA Kang T., Martins T., Sandowski I. RT Wild type GAL4 binds cooperatively th the GAL1-10 UASG in vitro RL J. Biol. Chem. 268:9629-9635 (1993). RN [6] RX MEDLINE; 92318924. RA Cowell I. G., Skinner A., Hurst H. C. RT Transcriptional repression by a novel member of the bZIP family of RT transcription factors RL Mol. Cell. Biol. 12:3070-3077 (1992). RN [7] RX MEDLINE; 91342628. RA Jones C., Lee K. A. W. RT E1A-mediated activation of the adenovirus E4 promoter can occur RT independently of the cellular transcription factor E4F RL Mol. Cell. Biol. 11:4297-4305 (1991). RN [8] RX MEDLINE; 91232900. RA Bakker O., Parker M. G. RT CAAT/enhancer binding protein is able to bind to ATF/CRE elements RL Nucleic Acids Res. 19:1213 (1991). RN [9] RX MEDLINE; 91219401. RA Hsu J. C., Laz T., Mohn K. L., Taub R. RT Identification of LRF-1, a leucine-zipper protein that is rapidly and RT highly induced in regenerating liver RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991). RN [10] RX MEDLINE; 91220647. RA Nicholas J., Nevins J. R. RT Distinct DNA targets for trans-activation by HTLV-1 tax and adenovirus E1A RL Virology 182:156-167 (1991). RN [11] RX MEDLINE; 90183984. RA Watanabe H., Wada T., Handa H. RT Transcription factor E4TF1 contains two subunits with different functions RL EMBO J. 9:841-847 (1990). RN [12] RX MEDLINE; 90205841. RA Ivashkiv L. B., Liou H.-C., Kara C. J., Lamph W. W., Verma I. M., Glimcher RA L. H. RT mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but RT not to the 12-O-tetradecanoylphorbol-13-acetate, response element RL Mol. Cell. Biol. 10:1609-1621 (1990). RN [13] RX MEDLINE; 91061725. RA Hurst H. C., Masson M., Jones N. C., Lee K. A. W. RT The cellular transcription factor CREB corresponds to activating RT transcription factor 47 (ATF-47) and forms complexes with a group of RT polypeptides related to ATF-43 RL Mol. Cell. Biol. 10:6192-6203 (1990). RN [14] RX MEDLINE; 90205810. RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H. RT A cDNA for a human cyclic AMP response element-binding protein which is RT distinct from CREB and expressed preferentially in brain RL Mol. Cell. Biol. 10:1347-1357 (1990). RN [15] RX MEDLINE; 90377203. RA Rooney R. J., Raychaudhuri P., Nevins J. R. RT E4F and ATF, two transcription factors that recognize the same site, can be RT distinguished both physically and functionally: a role for E4F in E1A trans RT activation RL Mol. Cell. Biol. 10:5138-5149 (1990). RN [16] RX MEDLINE; 91208099. RA Tassios P. T., La Thangue N. B. RT A multiplicity of differentiation-regulated ATF site-binding activities in RT embryonal carcinoma cells with distinct sequence and promoter specificities RL New Biol. 2:1123-1134 (1990). RN [17] RX MEDLINE; 90191714. RA Benbrook D. M., Jones N. C. RT Heterodimer formation between CREB and JUN proteins RL Oncogene 5:295-302 (1990). RN [18] RX MEDLINE; 90005408. RA Maekawa T., Sakura H., Kanei-Ishii C., Sudo T., Yoshimura T., Fujisawa RA J.-I., Yoshida M., Ishii S. RT Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP RT response element in brain RL EMBO J. 8:2023-2328 (1989). RN [19] RX MEDLINE; 89306600. RA Raychaudhuri P., Bagchi S., Nevins J. R. RT DNA-binding activity of the adenovirus-induced E4F transcription factor is RT regulated by phosphorylation RL Genes Dev. 3:620-627 (1989). RN [20] RX MEDLINE; 89098860. RA Lin Y.-S., Green M. R. RT Identification and purification of a Saccharomyces cerevisiae protein with RT the DNA binding specificity of mammalian activating transcription factor RL Proc. Natl. Acad. Sci. USA 86:109-113 (1989). RN [21] RX MEDLINE; 90078230. RA Merino A., Buckbinder L., Mermelstein F. H., Reinberg D. RT Phosphorylation of cellular proteins regulates their binding to the cAMP RT response element RL J. Biol. Chem. 264:21266-21276 (1989). RN [22] RX MEDLINE; 89278150. RA Miralles V. J., Cortes P., Stone N., Reinberg D. RT The adenovirus inverted terminal repeat functions as an enhancer in a RT cell-free system RL J. Biol. Chem. 264:10763-10772 (1989). RN [23] RX MEDLINE; 89261803. RA Tan T.-H., Horikoshi M., Roeder R. G. RT Purification and Characterization of Multiple Nuclear Factors That Bind to RT the TAX-Inducible Enhancer within the Human T-Cell Leukemia Virus Long RT Terminal Repeat RL Mol. Cell. Biol. 9:1733-1745 (1989). RN [24] RX MEDLINE; 89365161. RA Lin Y.-S., Green M. R. RT Similarities between prokaryotic and eukaryotic cyclic AMP-responsive RT promoter elements RL Nature 340:656-659 (1989). RN [25] RX MEDLINE; 89184591. RA Jones R. H., Jones N. C. RT Mammalian cAMP-responsive element can activate transcription in yeast and RT binds a yeast factor(s) that resembles the mammalian transcription factor RT ATF RL Proc. Natl. Acad. Sci. USA 86:2176-2180 (1989). RN [26] RX MEDLINE; 88327847. RA Horikoshi M., Hai T., Lin Y.-S., Green M. R., Roeder R. G. RT Transcription factor ATF interacts with the TATA factor to facilitate RT establishment of a preinitiation complex RL Cell 54:1033-1042 (1988). RN [27] RX MEDLINE; 88216605. RA Watanabe H., Imai T., Sharp P. A., Handa H. RT Identification of two transcription factors that bind to specific elements RT in the promoter of the adenovirus early-region 4 RL Mol. Cell. Biol. 8:1290-1300 (1988). RN [28] RX MEDLINE; 88217908. RA Lin Y.-S., Green M. R. RT Interaction of a common cellular transcription factor, ATF, with regulatory RT elements in both E1a- and cyclic AMP-inducible promoters RL Proc. Natl. Acad. Sci. USA 85:3396-3400 (1988). RN [29] RX MEDLINE; 88247984. RA Hardy S., Shenk T. RT Adenoviral control regions activated by E1A and the cAMP responsive element RT bind to the same factor RL Proc. Natl. Acad. Sci. USA 85:4171-4175 (1988). RN [30] RX MEDLINE; 87275829. RA Lee K. A. W., Green M. R. RT A cellular transcription factor E4F1 interacts with an E1A-inducible RT enhancer and mediates constitutive enhancer function in vitro RL EMBO J. 6:1345-1353 (1987). RN [31] RX MEDLINE; 88166652. RA Raychaudhuri P., Rooney R., Nevins J. R. RT Identification of an E1A-inducible cellular factor that interacts with RT regulatory sequences within the adenovirus E4 promoter RL EMBO J. 6:4073-4081 (1987). XX // AC G000009 XX ID AD2$IVA2 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD IVa2 promoter XX OS adenovirus type 2 OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX BC 6.3.3.3 XX BS -113 -89 R02015; AD2$IVA2_02; Binding factors: USF , USF1 BS . BS -50 -36 R00004; AD2$IVA2_01; Binding factors: Sp1 . BS -9 6 R03170; AD2$IVA2_04; Binding factors: TFIIA , TFIIB BS , TFIID , TFIIF , TFIIF-alpha , TFIIF-beta BS , TFIIA-alpha/beta precursor (major) , TFIIA-alpha/beta BS precursor (minor) , TFIIA-gamma , TFIIF . BS 10 22 R03165; AD2$IVA2_03; Binding factors: TBP , TBP BS . XX DR EMBL: X02996; AD5001. DR EMBL: J01917; HACG. DR TRANSPATH: G000009. DR TRRD: 00040. XX RN [1] RX MEDLINE; 92269862. RA Kasai Y., Chen H., Flint S. J. RT Anatomy of an unusual RNA polymerase II promoter containing a downstream RT TATA element RL Mol. Cell. Biol. 12:2884-2897 (1992). RN [2] RX MEDLINE; 91224350. RA Tamura T.-A., Mikoshiba K. RT Role of a GC-rich motif in transcription regulation of the adenovirus type RT 2 IVa2 promoter which lacks typical TATA-box element RL FEBS Lett. 282:87-90 (1991). RN [3] RX MEDLINE; 91376085. RA Carcamo J., Buckbinder L., Reinberg D. RT The initiator directs the assembly of a transcription factor IID-dependent RT transcription complex RL Proc. Natl. Acad. Sci. USA 88:8052-8056 (1991). RN [4] RX MEDLINE; 91071588. RA Carcamo J., Maldonado E., Cortes P., Ahn M.-H., Ha I., Flint J., Reinberg D. RT A TATA-like sequence located downstream of the transcription initiation RT site is required for expression of an RNA polymerase II transcribed gene RL Genes Dev. 4:1611-1622 (1990). RN [5] RX MEDLINE; 90370464. RA Moncollin V., Stalder R., Verdier J.-M., Sentenac A., Egly J.-M. RT A yeast homolog of the human UEF stimulates transcription from the RT adenovirus 2 major late promoter in yeast and in mammalian cell-free systems RL Nucleic Acids Res. 18:4817-4823 (1990). RN [6] RX MEDLINE; 88246423. RA Albrecht G., Devaux B., Kedinger C. RT Genomic Footprinting Detects Factors Bound to Major Late and IVa2 Promoters RT in Adenovirus-Infected HeLa Cells RL Mol. Cell. Biol. 8:1534-1539 (1988). XX // AC G000010 XX ID AD$MLP XX DT 14.06.1995 (created); dbo. DT 11.12.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD MLP XX DE major late promoter XX OS adenovirus OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX BC 6.3.3.4 XX BS -175 -130 R00986; AD$MLP_01. BS -120 -90 R03501; AD$MLP_40; Binding factors: USF1 . BS -95 -88 R00987; AD$MLP_02. BS -82 -71 R00988; AD$MLP_03; Binding factors: CP1A , NF-YA BS . BS -82 -71 R00989; AD$MLP_04; Binding factors: CP1A , HAP2 BS . BS -82 -71 R00990; AD$MLP_05; Binding factors: HAP3 , NF-YA BS . BS -74 -43 R00991; AD$MLP_06; Binding factors: NF-InsE2 , BS NF-InsE3 . BS -68 -49 R00992; AD$MLP_07; Binding factors: CG-1 , TFE3 BS , TFEB , TFII-I , USF1 , USF2 , BS v-Myc , Arnt , USF2 , USF2b . BS -68 -48 R00993; AD$MLP_08. BS -63 -52 R00994; AD$MLP_09; Binding factors: USF1 . BS -60 -52 R00995; AD$MLP_10; Binding factors: USF . BS -53 33 R00996; AD$MLP_11; Binding factors: TFIIA , TFIIB BS , TFIID , TFIIE , TFIIF , TFIIF-alpha BS , TFIIF-beta , TFIIA-alpha/beta precursor (major) , BS TFIIA-alpha/beta precursor (minor) , TFIIA-gamma , TFIIF BS . BS -51 32 R01605; AD$MLP_34; Binding factors: TFIIA , BS TFIIA-alpha/beta precursor (major) , TFIIA-alpha/beta precursor BS (minor) , TFIIA-gamma . BS -51 32 R01606; AD$MLP_35; Binding factors: TFIIA . BS -50 -10 R00997; AD$MLP_12. BS -47 20 R01017; AD$MLP_32; Binding factors: TFIIA , TFIIB BS , TFIID , TFIIA-alpha/beta precursor (major) , BS TFIIA-alpha/beta precursor (minor) , TFIIA-gamma . BS -47 30 R01018; AD$MLP_33; Binding factors: TFIIA , TFIIB BS , TFIID , TFIIE , TFIIA-alpha/beta precursor BS (major) , TFIIA-alpha/beta precursor (minor) , TFIIA-gamma BS . BS -42 -17 R01015; AD$MLP_30; Binding factors: TBP , TFIIA BS , TFIIA , TFIID , TFIIA-alpha/beta precursor BS (major) , TFIIA-alpha/beta precursor (minor) , TFIIA-gamma BS , TOA1 , TOA2 . BS -42 -17 R01016; AD$MLP_31; Binding factors: TBP , TFIIA BS , TFIIA , TFIIB , SUA7 , TFIIA-alpha/beta BS precursor (major) , TFIIA-alpha/beta precursor (minor) , BS TFIIA-gamma , TOA1 , TOA2 . BS -40 4 R00998; AD$MLP_13; Binding factors: En , TBP , BS TBP , TFIID . BS -40 35 R00999; AD$MLP_14; Binding factors: TFIID . BS -40 15 R03156; AD$MLP_39; Binding factors: NC2 , TBP . BS -39 -6 R01000; AD$MLP_15. BS -39 -17 R01014; AD$MLP_29; Binding factors: TFIID . BS -37 -17 R01619; AD$MLP_36; Binding factors: TFIID . BS -34 -22 R01001; AD$MLP_16; Binding factors: TBP , TBP BS , TBP , TBP-1 , TRF . BS -22 43 R02082; AD$MLP_38; Binding factors: USF1 . BS -12 18 R02081; AD$MLP_37; Binding factors: TFII-I . BS 8 26 R01002; AD$MLP_17; Binding factors: CBF (4) , TFIIA BS , TFIIB , TFIID , TFIIF , TFIIF-alpha BS , TFIIF-beta , TFIIA-alpha/beta precursor (major) , BS TFIIA-alpha/beta precursor (minor) , TFIIA-gamma , TFIIF BS . BS 24 50 R01003; AD$MLP_18; Binding factors: DF-1 . BS 28 34 R01004; AD$MLP_19. BS 37 68 R01005; AD$MLP_20; Binding factors: R1 . BS 64 84 R01006; AD$MLP_21; Binding factors: DF-2 . BS 83 105 R01007; AD$MLP_22; Binding factors: R2 . BS 86 92 R01008; AD$MLP_23; Binding factors: DEF . BS 91 107 R01009; AD$MLP_24; Binding factors: DF-3 . BS 105 122 R01010; AD$MLP_25. BS 113 120 R01011; AD$MLP_26; Binding factors: DEF . BS 146 165 R01012; AD$MLP_27; Binding factors: DTF . BS 320 352 R01013; AD$MLP_28. XX DR EMBL: X02996; AD5001. DR EMBL: X03000; AD7001. DR EMBL: M33540; ADBMLPA. DR EMBL: M14785; ADLE2B. DR EMBL: X73487; AT12CGA. DR EMBL: J01917; HACG. DR TRANSPATH: G000010. DR TRRD: 00007. XX RN [1] RX MEDLINE; 95199268. RA Sogawa K., Nakano R., Kobayashi A., Kikuchi Y., Ohe N., Matsushita N., RA Kuriyama Y. F. RT Possible function of Ah receptor nuclear translocator (Arnt) homodimer in RT transcriptional regulation RL Proc. Natl. Acad. Sci. USA 92:1936-1940 (1995). RN [2] RX MEDLINE; 93186811. RA Poon D., Knittle R. A., Sabelko K. A., Yamamoto T., Horikoshi M., Roeder R. RA G., Weil P. A. RT Genetic and biochemical analyses of yeast TATA-binding protein mutants RL J. Biol. Chem. 268:5005-5013 (1993). RN [3] RX MEDLINE; 93180835. RA Lorch Y., Kornberg R. D. RT Near-zero linking difference upon transcription factor IID binding to RT promoter DNA RL Mol. Cell. Biol. 13:1872-1875 (1993). RN [4] RX MEDLINE; 93156846. RA Crowley T. E., Hoey T., Liu J.-K., Jan Y. N., Jan L. Y., Tjian R. RT A new factor related to TATA-binding protein has highly restricted RT expression patterns in Drosophila RL Nature 361:557-561 (1993). RN [5] RX MEDLINE; 92354065. RA Inostroza J. A., Mermelstein F. H., Ha I., Lane W. S., Reinberg D. RT Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of RT class II gene transcription RL Cell 70:477-489 (1992). RN [6] RX MEDLINE; 93012951. RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J. RT Holo-TFIID supports transcriptional stimulation by diverse activators and RT from a TATA-less promoter RL Genes Dev. 6:1964-1974 (1992). RN [7] RX MEDLINE; 92283872. RA Hoopes B. C., LeBlanc J. F., Hawley D. J. RT Kinetic analysis of yeast TFIID-TATA box complex formation suggests a RT multi-step pathway RL J. Biol. Chem. 267:11539-11547 (1992). RN [8] RX MEDLINE; 93024456. RA Kirschbaum B. J., Pognonec P., Roeder R. G. RT Definition of the transcriptional activation domain of recombinant RT 43-kilodalton USF RL Mol. Cell. Biol. 12:5094-5101 (1992). RN [9] RX MEDLINE; 92103689. RA Lee D. K., Horikoshi M., Roeder R. G. RT Interaction of TFIID in the minor groove of the TATA element RL Cell 67:1241-1250 (1991). RN [10] RX MEDLINE; 92103688. RA Starr D. B., Hawley D. K. RT TFIID binds in the minor groove of the TATA box RL Cell 66:1231-1240 (1991). RN [11] RX MEDLINE; 92084106. RA Fisher D. E., Carr C. S., Parent L. A., Sharp P. A. RT TFEB has DNA-binding and oligomerization properties of a unique RT helix-loop-helix/leucine zipper family RL Genes Dev. 5:2342-2352 (1991). RN [12] RX MEDLINE; 91250402. RA Safer B., Reinberg D., Jacob W. F., Maldonado E., Carcamo J., Garfinkel S., RA Cohen R. RT Interaction of CAP sequence site binding factor and transcription factor RT IID preceding and following binding to the adenovirus 2 major late promoter RL J. Biol. Chem. 266:10989-10994 (1991). RN [13] RX MEDLINE; 92046085. RA Tronche F., Rollier A., Sourdive D., Cereghini S., Yaniv M. RT NFY or a related CCAAT binding factor can be replaced by other RT transcriptional activators for co-operation with HNF1 in driving the rat RT albumin promoter in vivo RL J. Mol. Biol. 222:31-43 (1991). RN [14] RX MEDLINE; 92017787. RA Pognonec P., Roeder R. G. RT Recombinant 43-kDa USF binds to DNA and activates transcription in a manner RT indistinguishable from that of natural 43/44-kDa USF RL Mol. Cell. Biol. 11:5125-5136 (1991). RN [15] RX MEDLINE; 92072699. RA Roy A. L., Meisterernst M., Pognonec P., Roeder R. G. RT Cooperative interaction of an initiator-binding transcription initiation RT factor and the helix-loop-helix activator USF RL Nature 354:245-248 (1991). RN [16] RX MEDLINE; 91288197. RA Mondesert G., Kedinger C. RT Cooperation between upstream and downstream elements of the adenovirus RT major late promoter for maximal late phase-specific transcription RL Nucleic Acids Res. 19:3221 (1991). RN [17] RX MEDLINE; 91239560. RA Kerkhoff E., Bister K., Klempnauer K.-H. RT Sequence-specific DNA binding by Myc protein RL Proc. Natl. Acad. Sci. USA 88:4323-4327 (1991). RN [18] RX MEDLINE; 91376085. RA Carcamo J., Buckbinder L., Reinberg D. RT The initiator directs the assembly of a transcription factor IID-dependent RT transcription complex RL Proc. Natl. Acad. Sci. USA 88:8052-8056 (1991). RN [19] RX MEDLINE; 91352017. RA Buratowski S., Sopta M., Greenblatt J., Sharp P. A. RT RNA polymerase II-associated proteins are required for a DNA conformation RT change in the transcription initiation complex RL Proc. Natl. Acad. Sci. USA 88:7509-7513 (1991). RN [20] RX MEDLINE; 90304877. RA Hoey T., Dynlacht B. D., Peterson M. G., Pugh B. F., Tjian R. RT Isolation and characterization of the Drosophila gene encoding the TATA box RT binding protein, TFIID RL Cell 61:1179-1186 (1990). RN [21] RX MEDLINE; 90228362. RA Zock C., Doerfler W. RT A mitigator sequence in the downstream region of the major late promoter of RT the adenovirus type 12 DNA RL EMBO J. 9:1615-1623 (1990). RN [22] RX MEDLINE; 91006002. RA Tamura T.-A., Sumita K., Hirose S., Mikoshiba K. RT Core promoter of the mouse myelin basic protein gene governs brain-specific RT transcription in vitro RL EMBO J. 9:3101-3108 (1990). RN [23] RX MEDLINE; 90249724. RA Beckmann H., Su L.-K., Kadesch T. RT TFE3: a helix-loop-helix protein that activates transcription through the RT immunoglobulin enhancer E3 motif RL Genes Dev. 4:167-179 (1990). RN [24] RX MEDLINE; 90285150. RA Garfinkel S., Thompson J. A., Jacob W. F., Cohen R., Safer B. RT Identification and Characterization of an Adenovirus 2 Major Late Promoter RT CAP Sequence DNA-Binding Protein RL J. Biol. Chem. 265:10309-10319 (1990). RN [25] RX MEDLINE; 90080161. RA Leong K., Lee W., Berk A. J. RT High-level transcription from the adenovirus major late promoter requires RT downstream binding sites for late-phase-specific factors RL J. Virol. 64:51-60 (1990). RN [26] RX MEDLINE; 91056553. RA Reach M., Babiss L. E., Young C. S. H. RT The upstream factor-binding site is not essential for activation of RT transcription from the adenovirus major late promoter RL J. Virol. 64:5851-5860 (1990). RN [27] RX MEDLINE; 90318407. RA Carr C. S., Sharp Ph. A. RT A Helix-Loop-Helix Protein Related to the Immunoglobulin E Box-Binding RT Proteins RL Mol. Cell. Biol. 10:4384-4388 (1990). RN [28] RX MEDLINE; 90377252. RA Buratowski S., Sharp Ph. A. RT Transcription initiation complexes and upstream activation with RNA RT polymerase II lacking the C-terminal domain of the largest subunit RL Mol. Cell. Biol. 10:5562-5564 (1990). RN [29] RX MEDLINE; 91061740. RA Maldonado E., Ha I., Cortes P., Weis L., Reinberg D. RT Factors involved in specific Transcription by mammalian RNA polymerase II: RT role of transcription factors IIA, IID, and IIB during formation of a RT transcription-component complex RL Mol. Cell. Biol. 10:6335-6347 (1990). RN [30] RX MEDLINE; 91133423. RA Mahajan P. B., Thompson jr E. A. RT Glucocorticoid inhibition of transcription from adenovirus major late RT promoter RL Mol. Endocrinol. 4:1515-1521 (1990). RN [31] RX MEDLINE; 90326196. RA Gasch A., Hoffmann A., Horikoshi M., Roeder R. G., Chua N.-H. RT Arabidopsis thaliana contains two gene for TFIID RL Nature 346:390-394 (1990). RN [32] RA Hoffmann A., Sinn E., Yamamoto T., Wang J., Roy A., Horikoshi M., Roeder R. RA G. RT Highly conserved core domain and unique N terminus with presumptive RT regulatory motifs in a human TATA factor (TFIID) RL Nature 346:387-390 (1990). RN [33] RX MEDLINE; 90370464. RA Moncollin V., Stalder R., Verdier J.-M., Sentenac A., Egly J.-M. RT A yeast homolog of the human UEF stimulates transcription from the RT adenovirus 2 major late promoter in yeast and in mammalian cell-free systems RL Nucleic Acids Res. 18:4817-4823 (1990). RN [34] RX MEDLINE; 90302006. RA Peterson M. G., Tanese N., Pugh B. F., Tjian R. RT Functional domains and upstream activation properties of cloned human TATA RT binding protein RL Science 248:1625-1630 (1990). RN [35] RX MEDLINE; 90241213. RA Yu X.-B., Burke C., Zhang J., Marchitelli L. J., Davis E. A., Ackermann S. RT Transcription factor IIA of wheat and human interacts similarly with the RT adenovirus-2 major late promoter RL Biochem. Biophys. Res. Commun. 168:498-505 (1990). RN [36] RX MEDLINE; 90287131. RA van Dyke M. W., Sawadogo M. RT DNA-binding and transcriptional properties of human transcription factor RT TFIID after mild proteolysis RL Mol. Cell. Biol. 10:3415-3420 (1990). RN [37] RX MEDLINE; 90192793. RA Ohkuma Y., Horikoshi M., Roeder R. G., Desplan C. RT Engrailed, a homeodomain protein, can repress in vitro transcription by RT competition with the TATA box-binding protein transcription factor IID RL Proc. Natl. Acad. Sci. USA 87:2289-2293 (1990). RN [38] RX MEDLINE; 89136002. RA Buratowski S., Hahn S., Guarente L., Sharp P. A. RT Five Intermediate Complexes in Transcription Initiation by RNA Polymerase II RL Cell 56:549-561 (1989). RN [39] RX MEDLINE; 89376568. RA Hahn S., Buratowski S., Sharp P. A., Guarente L. RT Isolation of the gene encoding the yeast TATA binding protein TFIID: A gene RT identical to the SPT15 suppressor of Ty element insertions RL Cell 58:1173-1181 (1989). RN [40] RX MEDLINE; 90059932. RA Hahn S., Buratowski S., Sharp P. A., Guarente L. RT Identification of a yeast protein homologous in function to the mammalian RT general transcription factor, TFIIA RL EMBO J. 8:3379-3382 (1989). RN [41] RX MEDLINE; 89214225. RA Carcamo J., Lobos S., Merino A., Buckbinder L., Weinmann R., Natarajan V., RA Reinberg D. RT Factors Involved in Specific Transcription by Mammalian RNA Polymerase II RL J. Biol. Chem. 264:7704-7714 (1989). RN [42] RX MEDLINE; 90064776. RA Jansen-Duerr P., Mondesert G., Kedinger C. RT Replication-dependent activation of the adenovirus major late promoter is RT mediated by the increased binding of a transcription factor to sequences in RT the first intron RL J. Virol. 63:5124-5132 (1989). RN [43] RX MEDLINE; 89219077. RA Chodosh L. A., Buratowski S., Sharp P. A. RT A Yeast Protein Possesses the DNA-Binding Properties of the Adenovirus RT Major Late Transcription Factor RL Mol. Cell. Biol. 9:820-822 (1989). RN [44] RX MEDLINE; 89296900. RA Horikoshi M., Wang C. K., Fuji H., Cromlish J. A., Weil P. A., Roeder R. G. RT Purification of a yeast TATA box-binding protein that exhibits human RT transcription factor IID activity RL Proc. Natl. Acad. Sci. USA 86:4843-4847 (1989). RN [45] RX MEDLINE; 89345538. RA Hahn S., Buratowski S., Sharp P. A., Guarente L. RT Yeast TATA-binding protein TFIID binds to TATA elements with both consensus RT and nonconsensus DNA sequences RL Proc. Natl. Acad. Sci. USA 86:5718-5722 (1989). RN [46] RX MEDLINE; 89386653. RA Staiger D., Kaulen H., Schell J. RT A CACGTG motif of the Antirrhinum majus chalcone synthase promoter is RT recognized by an evolutionarily conserved nuclear protein RL Proc. Natl. Acad. Sci. USA 86:6930-6934 (1989). RN [47] RX MEDLINE; 88165047. RA Chodosh L. A., Baldwin jr A. S., Carthew R. W., Sharp P. A. RT Human CCAAT-Binding Proteins Have Heterologous Subunits RL Cell 53:11-24 (1988). RN [48] RX MEDLINE; 88165053. RA Chodosh L. A., Olesen J., Hahn S., Baldwin jr A. S., Guarente L., Sharp P. RA A. RT A Yeast and a Human CCAAT-Binding Protein Have Heterologous Subunits That RT Are Functionally Interchangeable RL Cell 53:25-35 (1988). RN [49] RX MEDLINE; 89053051. RA Watt F., Molloy P. L. RT Cytosine methylation prevents binding to DNA of a HeLa cell transcription RT factor required for optimal expression of the adenovirus major late promoter RL Genes Dev. 2:1136-1143 (1988). RN [50] RX MEDLINE; 88273141. RA Cohen R. B., Yang L., Thompson J. A., Safer B. RT Identification of a Downstream Sequence and Binding Protein That Regulate RT Adenovirus Major Late Promoter Transcription in Vitro RL J. Biol. Chem. 263:10377-10385 (1988). RN [51] RX MEDLINE; 88246423. RA Albrecht G., Devaux B., Kedinger C. RT Genomic Footprinting Detects Factors Bound to Major Late and IVa2 Promoters RT in Adenovirus-Infected HeLa Cells RL Mol. Cell. Biol. 8:1534-1539 (1988). RN [52] RX MEDLINE; 89039826. RA Nakajima N., Horikoshi M., Roeder R. G. RT Factors Involved in Specific Transcription by Mammalian RNA Polymerase II: RT Purification, Gene Specificity, and TATA Box-Promoter Interactions of TFIID RL Mol. Cell. Biol. 8:4028-4040 (1988). RN [53] RX MEDLINE; 88302174. RA Moss L. G., Moss J. B., Rutter W. J. RT Systematic Binding Analysis of the Insulin Gene Transcription Control RT Region: Insulin and Immunoglobulin Enhancers Utilize Similar Transactivators RL Mol. Cell. Biol. 8:2620-2627 (1988). RN [54] RX MEDLINE; 88261539. RA Buratowski S., Hahn S., Sharp P. A., Guarente L. RT Function of a yeast TATA element-binding protein in a mammalian RT transcription system RL Nature 334:37-42 (1988). RN [55] RX MEDLINE; 88233979. RA Jansen-Duerr P., Boeuf H., Kedinger C. RT Replication-induced stimulation of the major late promoter of adenovirus is RT correlated to the binding of a factor to sequences in the first intron RL Nucleic Acids Res. 16:3771 (1988). RN [56] RX MEDLINE; 88124252. RA Nikolaev L. G., Glotov B. O., Belyavsky A. V., Grachev S. A., Levin A. V. RT Identification of sequence-specific DNA-binding factors by label transfer: RT application to the adenovirus-2 major late promoter RL Nucleic Acids Res. 16:519-535 (1988). RN [57] RX MEDLINE; 88082674. RA Lennard A. C., Egly J. M. RT Thr bidirectional upstream element of the adenovirus-2 major late promoter RT binds a single monomeric molecule of the upstream factor RL EMBO J. 6:3027-3034 (1987). RN [58] RX MEDLINE; 88042797. RA Chodosh L. A., Carthew R. W., Morgan J. G., Crabtree G. R., Sharp P. A. RT The Adenovirus Major Late Transcription Factor Activates the Rat RT gamma-Fibrinogen Promoter RL Science 238:684-688 (1987). RN [59] RX MEDLINE; 87053824. RA Moncollin V., Miyamoto N. G., Zheng X. M., Egly J. M. RT Identification of a factor specific for the upstream element of the RT adenovirus-2 major late promoter RL EMBO J. 5:2577-2584 (1986). RN [60] RX MEDLINE; 86232615. RA Shi X.-P., Lee R., Weinmann R. RT Protein factor(s) binding independently to two different regions of the RT adenovirus 2 major late promoter RL Nucleic Acids Res. 14:3729-3744 (1986). RN [61] RX MEDLINE; 86079486. RA Sawadogo M., Roeder R. G. RT Interaction of a Gene-Specific Transcription Factor with the Adenovirus RT Major Late Promoter Upstream of the TATA Box Region RL Cell 43:165-175 (1985). RN [62] RX MEDLINE; 86079526. RA Carthew R. W., Chodosh L. A., Struhl P. A. RT An RNA polymerase II transcription factor binds to an upstream element in RT the adenovirus major late promoter RL Cell 43:439-448 (1985). RN [63] RX MEDLINE; 86135996. RA Miyamoto N. G., Moncollin V., Egly J. M., Chambon P. RT Specific interaction between a transcription factor and the upstream RT element of the adenovirus-2 major late promoter RL EMBO J. 4:3563-3570 (1985). XX // AC G000011 XX ID AD2$ORI XX DT 14.06.1995 (created); dbo. DT 07.02.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ori XX DE origin of replication XX OS adenovirus type 2 OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX BC 6.3.3 XX BS 17 43 R01175; AD2$ORI_01; Binding factors: CTF-1 , NF-1 BS , NF-1 , NF-1 , DBP . BS 30 53 R01177; AD2$ORI_03; Binding factors: POU2F1 , POU6F1 BS . XX DR EMBL: J01917; HACG. DR TRANSPATH: G000011. XX RN [1] RX MEDLINE; 94192665. RA Wey E., Lyons G. E., Schaefer B. W. RT A human POU domain gene, mPOU, is expressed in developing brain and RT specific adult tissues RL Eur. J. Biochem. 220:753-762 (1994). RN [2] RX MEDLINE; 91012796. RA Mul Y. M., Verrijzer C. P., van der Vliet P. C. RT Transcription factors NFI and NFIII/oct-1 function independently, employing RT different mechanisms to enhance adenovirus DNA replication RL J. Virol. 64:5510-5518 (1990). RN [3] RX MEDLINE; 89354548. RA Mermod N., O'Neill E. A., Kelly T. J., Tjian R. RT The Proline-Rich Transcriptional Activator of CTF/NF-I Is Distinct from the RT Replication and DNA Binding Domain RL Cell 58:741-753 (1989). RN [4] RX MEDLINE; 89356660. RA Cleat P. H., Hay R. T. RT Co-operative interactions between NFI and the adenovirus DNA binding RT protein at the adenovirus origin of replication RL EMBO J. 8:1841-1848 (1989). RN [5] RX MEDLINE; 89214124. RA Amemiya K., Traub R., Durham L., Major E. O. RT Interaction of a Nuclear Factor-1-like Protein with the Regulatory Region RT of Human Polyomavirus JC Virus RL J. Biol. Chem. 264:7025-7032 (1989). RN [6] RX MEDLINE; 89178656. RA Janson L., Weller P., Pettersson U. RT Nuclear Factor I can Functionally Replace Transcription Factor Sp1 in a U2 RT Small Nuclear RNA Gene Enhancer RL J. Mol. Biol. 205:387-396 (1989). RN [7] RX MEDLINE; 89091990. RA Baumruker T., Sturm R., Herr W. RT OBP100 binds remarkably degenerate octamer motifs through specific RT interactions with flanking sequences RL Genes Dev. 2:1400-1413 (1988). RN [8] RX MEDLINE; 88247751. RA Meisterernst M., Gander I., Rogge L., Winnacker E.-L. RT A quantitative analysis of a nuclear factor 1/DNA interaction RL Nucleic Acids Res. 16:4419-4435 (1988). RN [9] RX MEDLINE; 87078403. RA Jones K. A., Kadonaga J. T., Rosenfeld P. J., Kelly T. J., Tjian R. RT A cellular DNA-binding protein that activates eukaryotic transcription and RT replication RL Cell 48:79-89 (1987). RN [10] RX MEDLINE; 86140112. RA Adhya S., Shneidman P. S., Hurwitz J. RT Reconstruction of adenovirus replication origins with a human nuclear RT factor I binding site RL J. Biol. Chem. 261:3339-3346 (1986). RN [11] RX MEDLINE; 87064414. RA Diffley J. F. X., Stillman B. RT Purification of a cellular, double-stranded DNA-binding protein required RT for initiation of adenovirus DNA replication by using a rapid RT filter-binding assay RL Mol. Cell. Biol. 6:1363-1373 (1986). RN [12] RX MEDLINE; 84248049. RA Gronostajski R. M., Nagata K., Hurwitz J. RT Isolation of human DNA sequences that bind to nuclear factor I, a host RT protein involved in adenovirus DNA replication RL Proc. Natl. Acad. Sci. USA 81:4013-4017 (1984). XX // AC G000012 XX ID AKV$AKV XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD AKV MLV XX DE murine leukemia virus XX OS AKV MLV, AKV murine leukemia virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; mammalian type C OC oncoviruses; murine leukemia viruses XX BC 6.2.1.2 XX BS empty empty R04249; AKV$AKV_01; Binding factors: ALF1B . XX DR EMBL: J01998; MLOCG. DR TRANSPATH: G000012. DR TRRD: 00009. XX RN [1] RX MEDLINE; 95302506. RA Bonven B. J., Nielsen A. L., Norby P. L., Pedersen F. S., Jorgensen P. RT E-box variants direct formation of distinct complexes with the basic RT helix-loop-helix protein ALF1 RL J. Mol. Biol. 249:564-575 (1995). RN [2] RX MEDLINE; 92334344. RA Nielsen A. L., Pallisgaard N., Pedersen F. S., Jorgensen P. RT Murine helix-loop-helix transcriptional activator proteins binding to the RT E-box motif of the Akv murine leukemia virus enhancer identified by cDNA RT cloning RL Mol. Cell. Biol. 12:3449- 3459 (1992). XX // AC G000014 XX ID ALV$LTR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ALV LTR XX DE avian leukosis virus XX OS ALV, avian leukosis virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; avian type C OC oncoviruses; avian leukosis viruses XX BC 6.2.1.3 XX BS empty empty R01824; ALV$LTR_06; Binding factors: EFII . BS empty empty R01825; ALV$LTR_02; Binding factors: EFII . BS empty empty R01826; ALV$LTR_01; Binding factors: EFII . BS empty empty R01827; ALV$LTR_03. BS empty empty R01828; ALV$LTR_05. BS empty empty R01829; ALV$LTR_04. XX DR TRANSPATH: G000014. XX RN [1] RX MEDLINE; 90066519. RA Ruddell A., Linial M. L., Groudine M. RT Tissue-Specific Lability and Expression of Avian Leukosis Virus Long RT Terminal Repeat Enhancer-Binding Proteins RL Mol. Cell. Biol. 9:5660-5668 (1989). XX // AC G000015 XX ID AMULV$AMULV XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD A-MuLV XX OS A-MuLV, amphotropic murine leukemia virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; mammalian type C OC oncoviruses; murine leukemia viruses XX BS -87 -59 R00101; AMULV$AMULV_01. XX RN [1] RX MEDLINE; 88065491. RA Flamant F., Gurin C. C., Sorge J. A. RT An Embryonic DNA-Binding Protein Specific for the Promoter of the RT Retrovirus Long Terminal Repeat RL Mol. Cell. Biol. 7:3548-3553 (1987). XX // AC G000016 XX ID AMV$AMV XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD AMV XX DE avian myeloblastosis virus XX OS AMV, avian myeloblastosis virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; avian type C oncoviruses XX BC 6.2.1.3 XX BS -262 -241 R00102; AMV$AMV_01; Binding factors: C/EBPalpha . BS -154 -134 R00103; AMV$AMV_02; Binding factors: C/EBPalpha . BS -57 -37 R00104; AMV$AMV_03; Binding factors: C/EBPalpha . XX DR EMBL: M24159; ALMAMV. DR EMBL: K00388; RELTR2. DR TRANSPATH: G000016. XX RN [1] RX MEDLINE; 89261719. RA Ryden T. A., Beemon K. RT Avian Retroviral Long Terminal Repeats Bind CCAAT/Enhancer-Binding Protein RL Mol. Cell. Biol. 9:1155-1164 (1989). XX // AC G000017 XX ID ASPN$ABAA XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD abaA XX OS Aspergillus nidulans, Emericella nidulans OC Eukaryota; Fungi; Ascomycota; Euascomycetes; Plectomycetes; Eurotiales; OC Trichocomaceae; Emericella. XX BS -488 -472 R03760; ASPN$ABAA_01; Binding factors: abaA . BS -456 -440 R03761; ASPN$ABAA_02; Binding factors: abaA . BS -414 -398 R03784; ASPN$ABAA_06; Binding factors: abaA . BS -19 -3 R03762; ASPN$ABAA_03; Binding factors: abaA . BS 4 20 R03763; ASPN$ABAA_04; Binding factors: abaA . BS 118 135 R03764; ASPN$ABAA_05; Binding factors: abaA . XX DR EMBL: J04850; ANABAA. DR TRANSPATH: G000017. XX RN [1] RX MEDLINE; 94187722. RA Andrianopoulos A., Timberlake W. E. RT The Aspergillus nidulans abaA gene encodes a transcriptional activator that RT acts as a genetic switch to control development RL Mol. Cell. Biol. 14:2503-2515 (1994). XX // AC G000018 XX ID ASPN$AMDS XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD amdS XX DE acetamidase XX OS Aspergillus nidulans, Emericella nidulans OC Eukaryota; Fungi; Ascomycota; Euascomycetes; Plectomycetes; Eurotiales; OC Trichocomaceae; Emericella. XX BS -558 -551 R08608; ASPN$AMDS_05; Binding factors: FACB . BS -178 -168 R08592; ASPN$AMDS_04; Binding factors: FACB . BS -157 -132 R03276; ASPN$AMDS_01; Binding factors: AmdR , AnCF BS . BS -144 -109 R03277; ASPN$AMDS_02; Binding factors: AnCF . BS -84 -70 R08590; ASPN$AMDS_03; Binding factors: FACB . XX DR EMBL: M16371; ANAMDS. DR TRANSPATH: G000018. DR BRENDA: 3.5.1.4. XX RN [1] RX MEDLINE; 98190085. RA Todd R. B., Andrianopoulos A., Davis M. A., Hynes M. J. RT FacB, the Aspergillus nidulans activator of acetate utilization genes, RT binds dissimilar DNA sequences RL EMBO J. 17:2042-2054 (1998). RN [2] RX MEDLINE; 91252209. RA van Heeswijck R., Hynes M. J. RT The amdR product and a CCAAT-binding factor bind to adjacent, possibly RT overlapping DNA sequences in the promoter region of the Aspergillus RT nidulans amdS gene RL Nucleic Acids Res. 19:2655-2660 (1991). XX // AC G000019 XX ID ASPN$BRLA XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD brlA XX OS Aspergillus nidulans, Emericella nidulans OC Eukaryota; Fungi; Ascomycota; Euascomycetes; Plectomycetes; Eurotiales; OC Trichocomaceae; Emericella. XX BS -220 -206 R03765; ASPN$BRLA_01; Binding factors: abaA . BS -15 -3 R03766; ASPN$BRLA_02; Binding factors: abaA . BS 6 20 R03785; ASPN$BRLA_05; Binding factors: abaA . BS 75 84 R03767; ASPN$BRLA_03; Binding factors: abaA . BS 136 150 R03768; ASPN$BRLA_04; Binding factors: abaA . XX DR EMBL: M20631; ANBRLA. DR TRANSPATH: G000019. XX RN [1] RX MEDLINE; 94187722. RA Andrianopoulos A., Timberlake W. E. RT The Aspergillus nidulans abaA gene encodes a transcriptional activator that RT acts as a genetic switch to control development RL Mol. Cell. Biol. 14:2503-2515 (1994). XX // AC G000020 XX ID ASPN$NIAD XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD niaD-niiA XX DE nitrate reductase-nitrite reductase XX OS Aspergillus nidulans, Emericella nidulans OC Eukaryota; Fungi; Ascomycota; Euascomycetes; Plectomycetes; Eurotiales; OC Trichocomaceae; Emericella. XX BS empty empty R02728; ASPN$NIAD_01; Binding factors: NIT2 . BS empty empty R02729; ASPN$NIAD_02; Binding factors: NIT2 . BS empty empty R02730; ASPN$NIAD_03; Binding factors: NIT2 . BS empty empty R02731; ASPN$NIAD_04; Binding factors: NIT2 . XX DR EMBL: M77022; ANNIADO. DR EMBL: M58289; ANNIIA. DR TRANSPATH: G000020. DR BRENDA: 1.7.99.4. XX RN [1] RX MEDLINE; 90319106. RA Fu Y.-H., Marzluf G. A. RT nit-2, the major positive-acting nitrogen regulatory gene of Neurospora RT crassa, encodes a sequence-specific DNA-binding protein RL Proc. Natl. Acad. Sci. USA 87:5331-5335 (1990). XX // AC G000021 XX ID ASPN$RODA XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD rodA XX OS Aspergillus nidulans, Emericella nidulans OC Eukaryota; Fungi; Ascomycota; Euascomycetes; Plectomycetes; Eurotiales; OC Trichocomaceae; Emericella. XX BS -545 -531 R03774; ASPN$RODA_01; Binding factors: abaA . BS -399 -383 R03775; ASPN$RODA_02; Binding factors: abaA . BS -321 -306 R03776; ASPN$RODA_03; Binding factors: abaA . BS -151 -136 R03777; ASPN$RODA_04; Binding factors: abaA . BS 19 35 R03778; ASPN$RODA_05; Binding factors: abaA . XX DR EMBL: M61113; ENRODAA. DR TRANSPATH: G000021. XX RN [1] RX MEDLINE; 94187722. RA Andrianopoulos A., Timberlake W. E. RT The Aspergillus nidulans abaA gene encodes a transcriptional activator that RT acts as a genetic switch to control development RL Mol. Cell. Biol. 14:2503-2515 (1994). XX // AC G000022 XX ID ASPN$WETA XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD wetA XX OS Aspergillus nidulans, Emericella nidulans OC Eukaryota; Fungi; Ascomycota; Euascomycetes; Plectomycetes; Eurotiales; OC Trichocomaceae; Emericella. XX BS -315 -302 R03769; ASPN$WETA_01; Binding factors: abaA . BS -128 -114 R03770; ASPN$WETA_02; Binding factors: abaA . BS -100 -85 R03771; ASPN$WETA_03; Binding factors: abaA . BS 51 65 R03772; ASPN$WETA_04; Binding factors: abaA . XX DR EMBL: M60528; ANWETA. DR TRANSPATH: G000022. XX RN [1] RX MEDLINE; 94187722. RA Andrianopoulos A., Timberlake W. E. RT The Aspergillus nidulans abaA gene encodes a transcriptional activator that RT acts as a genetic switch to control development RL Mol. Cell. Biol. 14:2503-2515 (1994). XX // AC G000023 XX ID ASPN$YA XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD yA XX DE conidial pigmentation gene, laccase I XX OS Aspergillus nidulans, Emericella nidulans OC Eukaryota; Fungi; Ascomycota; Euascomycetes; Plectomycetes; Eurotiales; OC Trichocomaceae; Emericella. XX BS -89 -76 R03759; ASPN$YA_01; Binding factors: abaA . BS -69 -55 R03773; ASPN$YA_02; Binding factors: abaA . XX DR EMBL: X52552; ANYALAC. DR TRANSPATH: G000023. DR BRENDA: 1.10.3.2; Aspergillus_nidulans. XX RN [1] RX MEDLINE; 94187722. RA Andrianopoulos A., Timberlake W. E. RT The Aspergillus nidulans abaA gene encodes a transcriptional activator that RT acts as a genetic switch to control development RL Mol. Cell. Biol. 14:2503-2515 (1994). XX // AC G000024 XX ID AT$ADH1 XX DT 14.06.1995 (created); dbo. DT 26.02.2001 (updated); rge. CO Copyright (C), Biobase GmbH. XX SD adh1 XX DE alcohol dehydrogenase 1 XX OS thale cress, Arabidopsis thaliana OC eukaryota; viridiplantae; embryobionta; magnoliophyta; magnoliopsida; OC dilleniidae; capparales; brassicaceae XX BC 1.1.4.10 XX BS -312 -305 R09886; AT$ADH1_05. BS -223 -201 R03630; AT$ADH1_01; Binding factors: GBF1 , GBF2 BS , GBF3 , GBF1 . BS -203 -185 R09880; AT$ADH1_03; Binding factors: MYB2 . BS -195 -170 R09885; AT$ADH1_04. BS -163 -148 R09879; AT$ADH1_02; Binding factors: MYB2 . BS -149 -143 R09887; AT$ADH1_06. XX DR EMBL: M12196; ATADH. DR TRANSPATH: G000024. DR BRENDA: 1.1.1.1. XX RN [1] RX MEDLINE; 9611167. RA Hoeren F. U., Dolferus R., Wu Y., Peacock W. J., Dennis E. S. RT Evidence for a role for AtMYB2 in the induction of the Arabidopsis alcohol RT dehydrogenase gene (ADH1) by low oxygen RL Genetics 149:479-490 (1998). RN [2] RX MEDLINE; 95261412. RA de Vetten N. C., Ferl R. J. RT Characterization of a maize G-box binding factor that is induced by hypoxia RL Plant J. 7:589-601 (1995). RN [3] RX MEDLINE; 7972489. RA Dolferus R., Jacobs M., Peacock W. J., Dennis E. S. RT Differential interactions of promoter elements in stress responses of the RT Arabidopsis Adh gene RL Plant Physiol. 105:1075-1087 (1994). RN [4] RX MEDLINE; 92224864. RA Schindler U., Menkens A. E., Beckmann A., Ecker J. R., Cashmore A. R. RT Heterodimerization between light-regulated and ubiquitous expressed RT Arabidopsis GBF bZIP proteins RL EMBO J. 11:1261-1273 (1992). RN [5] RA Ferl R. J., Laughner B. H. RT In vivo detection of regulatory factor binding sites of Arabidopsis Adh RL Plant Mol. Biol. 12:357-366 (1989). XX // AC G000025 XX ID AT$DBP XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD dbp XX DE DNA-binding protein XX OS thale cress, Arabidopsis thaliana OC eukaryota; viridiplantae; embryobionta; magnoliophyta; magnoliopsida; OC dilleniidae; capparales; brassicaceae XX BC 1.1.5.1 XX BS -246 -227 R03283; AT$DBP_01; Binding factors: HBP-1a , HBP-1b BS , GBF1 , OBF4 , OBF5 , OBF3.1 , BS OBF3.2 , TGA1 , TGA3 , TGA6 . XX DR EMBL: M25268; ATDNABP. DR TRANSPATH: G000025. XX RN [1] RX MEDLINE; 97369364. RA Xiang C., Miao Z., Lam E. RT DNA-binding properties, genomic organization and expression pattern of RT TGA6, a new member of the TGA family of bZIP transcription factors in RT Arabidopsis thaliana. RL Plant Mol. Biol. 34:403-415 (1997). RN [2] RX MEDLINE; 96017785. RA Lam E., Lam Y. K.-P. RT Binding site requirements and differential representation of TGA factors in RT nuclear ASF-1 activity RL Nucleic Acids Res. 23:3778-3785 (1995). RN [3] RX MEDLINE; 94073225. RA Zhang B., Foley R. C., Singh K. B. RT Isolation and characterization of two related Arabidopsis ocs-element bZIP RT binding proteins RL Plant J. 4:711-716 (1993). RN [4] RX MEDLINE; 93386190. RA Foley R. C., Grossman C., Ellis J. G., Llewellyn D. J., Dennis E. S., RA Peacock W. J., Singh K. B. RT Isolation of a maize bZIP protein subfamily-candidates for the ocs-element RT transcription factor RL Plant J. 3:669-679 (1993). RN [5] RX MEDLINE; 91224097. RA Tabata T., Nakayama T., Mikami K., Iwabuchi M. RT HBP-1a and HBP-1b: leucine zipper-type transcription factors of wheat RL EMBO J. 10:1459-1467 (1991). XX // AC G000026 XX ID AT$RS1A XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD rbcS-1A XX DE ribulose 1,5-bisphosphate carboxylase, small subunit gene 1A XX OS thale cress, Arabidopsis thaliana OC eukaryota; viridiplantae; embryobionta; magnoliophyta; magnoliopsida; OC dilleniidae; capparales; brassicaceae XX BS -241 -230 R01315; AT$RS1A_01; Binding factors: GBF , GBF1 BS , GBF2 , GBF3 , GBF , GBF1 , OSBZ8 BS , HY5 , PIF3 . XX DR EMBL: X14565; ATRBCSA. DR TRANSPATH: G000026. DR BRENDA: 4.1.1.39. XX RN [1] RX MEDLINE; 98258993. RA Chattopadhyay S., Ang L.-H., Puente P., Deng X.-W., Wei N. RT Arabidopsis bZIP protein HY5 directly interacts with light-responsive RT promoters in mediating light control of gene expression. RL Plant Cell 10:673-683 (1998). RN [2] RX MEDLINE; 96417817. RA Nakagawa H., Ohmiya K., Hattori T. RT A rice bZIP protein, designated OSBZ8, is rapidly induced by abscisic acid. RL Plant J. 9:217-227 (1996). RN [3] RX MEDLINE; 95261412. RA de Vetten N. C., Ferl R. J. RT Characterization of a maize G-box binding factor that is induced by hypoxia RL Plant J. 7:589-601 (1995). RN [4] RX MEDLINE; 92224864. RA Schindler U., Menkens A. E., Beckmann A., Ecker J. R., Cashmore A. R. RT Heterodimerization between light-regulated and ubiquitous expressed RT Arabidopsis GBF bZIP proteins RL EMBO J. 11:1261-1273 (1992). RN [5] RX MEDLINE; 90269205. RA Donald R. G. K., Schindler U., Batschauer A., Cashmore A. R. RT The plant G box promoter sequence activates transcription in Saccharomyces RT cerevisiae and is bound in vitro by a yeast activity similar to GBF, the RT plant G box binding factor RL EMBO J. 9:1727-1735 (1990). XX // AC G000027 XX ID AT$EF1A1 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD EF-1alpha A1 XX DE translation elongation factor-1alpha XX OS thale cress, Arabidopsis thaliana OC eukaryota; viridiplantae; embryobionta; magnoliophyta; magnoliopsida; OC dilleniidae; capparales; brassicaceae XX BS -106 -82 R03062; AT$EF1A1_01; Binding factors: TEF 1 . XX DR EMBL: X16430; ATEF1AA1. DR TRANSPATH: G000027. XX RN [1] RX MEDLINE; 91232913. RA Curie C., Liboz T., Bardet C., Gander E., Medale C., Axelos M., Lescure B. RT Cis and trans-acting elements involved in the activation of Arabidopsis RT thaliana A1 gene encoding the translation elongation factor EF-1alpha RL Nucleic Acids Res. 19:1305-1310 (1991). XX // AC G000028 XX ID AT$EF1A4 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD EF-1 alpha A4 XX DE translation elongation factor-1alpha XX OS thale cress, Arabidopsis thaliana OC eukaryota; viridiplantae; embryobionta; magnoliophyta; magnoliopsida; OC dilleniidae; capparales; brassicaceae XX BS -158 -14 R03063; AT$EF1A4_01; Binding factors: TEF 1 . XX DR TRANSPATH: G000028. XX RN [1] RX MEDLINE; 91232913. RA Curie C., Liboz T., Bardet C., Gander E., Medale C., Axelos M., Lescure B. RT Cis and trans-acting elements involved in the activation of Arabidopsis RT thaliana A1 gene encoding the translation elongation factor EF-1alpha RL Nucleic Acids Res. 19:1305-1310 (1991). XX // AC G000029 XX ID BACU$BACV XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD BACV XX DE baculovirus XX OS baculovirus, Autographa californica OC viridae; ds-DNA enveloped viruses; baculoviridae; baculovirus; nuclear OC polyhedrosis viruses XX BS empty empty R03410; BACU$BACV_01; Binding factors: IE1 . XX DR TRANSPATH: G000029. XX RN [1] RX MEDLINE; 91251220. RA Guarino L. A., Dong W. RT Expression of an enhancer-binding protein in insect cells transfected with RT the Autographa californica nuclear polyhedrosis virus IE1 gene RL J. Virol. 65:3676-3680 (1991). XX // AC G000030 XX ID BKV$BKV XX DT 14.06.1995 (created); dbo. DT 11.12.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD BKV XX DE human polyomavirus BK XX OS BKV, human polyomavirus BK OC viridae; ds-DNA nonenveloped viruses; papovaviridae; polyomaviruses XX BC 6.3.6 XX BS 152 182 R00167; BKV$BKV_01; Binding factors: NF-1 , NF-1 BS . BS 165 177 R01774; BKV$BKV_08; Binding factors: NF-1 . BS 178 190 R01775; BKV$BKV_05. BS 200 228 R00168; BKV$BKV_02. BS 210 0 R01776; BKV$BKV_07; Binding factors: AP-1 . BS 255 284 R00169; BKV$BKV_03; Binding factors: NF-1 , NF-1 BS . BS 260 0 R01777; BKV$BKV_06; Binding factors: AP-1 . BS 298 330 R00170; BKV$BKV_04. XX DR EMBL: D00678; PAPPLYBKG. DR EMBL: M24735; PAPPLYREP. DR EMBL: S67523; S67523. DR TRANSPATH: G000030. XX RN [1] RX MEDLINE; 89384609. RA Chakraborty T., Das G. C. RT Identification of HeLa Cell Nuclear Factors That Bind to and Activate the RT Early Promoter of Human Polyomavirus BK In Vitro RL Mol. Cell. Biol. 9:3821-3828 (1989). RN [2] RX MEDLINE; 89096938. RA Grinnell B. W., Berg D. T., Walls J. D. RT Negative Regulation of the Human Polyomavirus BK Enhancer Involves RT Cell-Specific Interaction with a Nuclear Repressor RL Mol. Cell. Biol. 8:3448-3457 (1988). XX // AC G000031 XX ID BOMMO$CHOR XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CHOR XX DE chorion protein XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; lepidoptera; OC bombycoidea; bombycidae XX BC 3.1.2.7 XX BS -97 -82 R03049; BOMMO$CHOR_01; Binding factors: BCFII . BS -67 -51 R03050; BOMMO$CHOR_02; Binding factors: BCFI . XX DR EMBL: X01836; BMCHOG2. DR TRANSPATH: G000031. XX RN [1] RX MEDLINE; 91172181. RA Skeiky Y. A. W., Iatrou K. RT Synergistic interactions of silkmoth chorion promoter-binding factors RL Mol. Cell. Biol. 11:1954-1964 (1991). XX // AC G000032 XX ID BOMMO$F XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD fibroin XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; lepidoptera; OC bombycoidea; bombycidae XX BS -234 -66 R00448; BOMMO$F_01; Binding factors: 75 kDa protein . BS -217 -174 R00449; BOMMO$F_02; Binding factors: SGF-2 , SGF-3 BS , SGF-4 . BS -169 -139 R00450; BOMMO$F_03; Binding factors: SGF-2 , SGF-3 BS , SGF-4 . BS -132 -100 R00451; BOMMO$F_04; Binding factors: SGF-2 , SGF-3 BS , SGF-4 . BS -89 -68 R02718; BOMMO$F_07; Binding factors: SGF-1 . BS -65 -44 R02719; BOMMO$F_08; Binding factors: FBF-A1 , SGF-1 BS . BS -42 -16 R00452; BOMMO$F_05. BS -8 8 R00453; BOMMO$F_06. BS 200 227 R05009; BOMMO$F_09; Binding factors: SGF-1 . BS 279 306 R05010; BOMMO$F_10; Binding factors: SGF-1 , SGF-3 BS . BS 403 440 R05011; BOMMO$F_11; Binding factors: SGF-3 . XX DR EMBL: V00094; BMFIBR. DR TRANSPATH: G000032. XX RN [1] RX MEDLINE; 97184648. RA Takiya S., Kokubo H., Suzuki Y. RT Transcriptional regulatory elements in the upstream and intron of the RT fibroin gene bind three specific factors POU-M1, Bm Fkh and FMBP-1 RL Biochem. J. 321:645-653 (1997). RN [2] RX MEDLINE; 90151625. RA Takiya S., Hui C.-C., Suzuki Y. RT A contribution of the core-promoter and its surrounding regions to the RT preferential transcription of the fibroin gene in posterior silk gland RT extracts RL EMBO J. 9:489-496 (1990). RN [3] RX MEDLINE; 90294285. RA Hui C.-C., Matsuno K., Suzuki Y. RT Fibroin Gene Promoter Contains a Cluster of Homeodomain Binding Sites that RT Interact with Three Silk Gland Factors RL J. Mol. Biol. 213:651-670 (1990). RN [4] RX MEDLINE; 89174718. RA Matsuno K., Suzuki T., Takiya S., Suzuki Y. RT Complex Formation with the Fibroin Gene Enhancer through a Protein-Protein RT Interaction Analyzed by a Modified DNA-binding Assay RL J. Biol. Chem. 264:4599-4604 (1989). RN [5] RX MEDLINE; 88186926. RA Suzuki T., Suzuki Y. RT Interaction of Composite Protein Complex with Fibroin Enhancer Sequence RL J. Biol. Chem. 263:5979-5986 (1988). XX // AC G000033 XX ID BOMMO$SER1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Ser-1 XX DE sericin-1 XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; lepidoptera; OC bombycoidea; bombycidae XX BC 3.1.2.6 XX BS -204 -183 R02645; BOMMO$SER1_01; Binding factors: SGF-3 . BS -149 -135 R02646; BOMMO$SER1_02. BS -103 -85 R02647; BOMMO$SER1_03. XX DR EMBL: J01029; BMSERI71. DR EMBL: J01035; BMSERI91. DR TRANSPATH: G000033. DR TRRD: 00174. XX RN [1] RX MEDLINE; 97184648. RA Takiya S., Kokubo H., Suzuki Y. RT Transcriptional regulatory elements in the upstream and intron of the RT fibroin gene bind three specific factors POU-M1, Bm Fkh and FMBP-1 RL Biochem. J. 321:645-653 (1997). RN [2] RX MEDLINE; 90036979. RA Matsuno K., Hui C.-C., Takiya S., Suzuki T., Ueno K., Suzuki Y. RT Transcription Signals and Protein Binding Sites for Sericine Gene RT Transcription in Vitro RL J. Biol. Chem. 264:18707-18713 (1989). XX // AC G000034 XX ID BOVIN$AS2CAS XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD alpha-s2 casein XX OS cattle, Bos taurus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; artiodactyla; ruminantia; pecora; bovidae XX BC 6.1.3.5 XX DR TRRD: 00012. XX // AC G000035 XX ID BOVIN$CYTOP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CYP17 XX DE cytochrome P-450 17alpha XX OS cattle, Bos taurus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; artiodactyla; ruminantia; pecora; bovidae XX BC 6.1.4.9.1 XX BS -297 -225 R02047; BOVIN$CYTOP_01. XX RN [1] RX MEDLINE; 90153983. RA Lund J., Ahlgren R., Wu D., Kagimoto M., Simpson E. R., Waterman M. R. RT Transcriptional Regulation of the Bovine CYP17 (P-45017alpha) Gene RL J. Biol. Chem. 265:3304-3312 (1990). XX // AC G000037 XX ID BOVIN$PPTA XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD PPT-A XX DE preprotachykinin A; substance P precursor XX OS cattle, Bos taurus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; artiodactyla; ruminantia; pecora; bovidae XX BC 6.1.5.5.1 XX BS -199 -180 R04044; BOVIN$PPTA_01; Binding factors: C/EBPdelta , BS CRE-BP2 . XX DR EMBL: X01395; BTPPT1. DR TRANSPATH: G000037. XX RN [1] RX MEDLINE; 91332085. RA Kageyama R., Sasai Y., Nakanishi S. RT Molecular characterization of transcription factors that bind to the cAMP RT responsive region of the substance P precursor gene RL J. Biol. Chem. 266:15525-15531 (1991). XX // AC G000038 XX ID BOVIN$PTH XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD PTH XX DE parathyroid hormone XX OS cattle, Bos taurus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; artiodactyla; ruminantia; pecora; bovidae XX BC 6.1.5.4 XX BS -52 -41 R01196; BOVIN$PTH_01; Binding factors: CREB . XX DR EMBL: K01938; BTPTHG. DR TRANSPATH: G000038. XX RN [1] RX MEDLINE; 90192168. RA Englander E. W., Wilson S. H. RT Protein binding elements in the human beta-polymerase promoter RL Nucleic Acids Res. 18:919-928 (1990). XX // AC G000039 XX ID BOVIN$TG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD TG XX DE thyroglobulin XX OS cattle, Bos taurus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; artiodactyla; ruminantia; pecora; bovidae XX BS -250 9 R04028; BOVIN$TG_01. XX RN [1] RX MEDLINE; 89338965. RA Christophe D., Gerard C., Juvenal G., Bacolla A., Teugels E., Ledent C., RA Christophe-Hobertus C., Dumont J. E., Vassart G. RT Identification of a cAMP-responsive region in thyroglobulin gene promoter RL Mol. Cell. Endocrinol. 64:5-18 (1989). XX // AC G000040 XX ID BPV1$BPV1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD BPV-1 XX DE bovine papilloma virus-1 XX OS BPV-1, bovine papilloma virus type 1 OC viridae; ds-DNA nonenveloped viruses; papovaviridae; papillomavirus XX BC 6.3.4 XX BS 16 31 R00188; BPV1$BPV1_18; Binding factors: E2 . BS 855 870 R00189; BPV1$BPV1_19; Binding factors: E2 . BS 1125 1140 R00190; BPV1$BPV1_20; Binding factors: E2 . BS 2396 2411 R00191; BPV1$BPV1_21; Binding factors: E2 , Sp1 BS . BS 2921 2936 R00192; BPV1$BPV1_22; Binding factors: E2 . BS 2951 2965 R03282; BPV1$BPV1_24; Binding factors: Sp1 . BS 3088 3103 R00193; BPV1$BPV1_23; Binding factors: E2 . BS 7202 7218 R00171; BPV1$BPV1_01; Binding factors: E2 . BS 7267 7281 R00172; BPV1$BPV1_02; Binding factors: E2 . BS 7365 7380 R00173; BPV1$BPV1_03; Binding factors: E2 . BS 7408 7423 R00174; BPV1$BPV1_04; Binding factors: E2 . BS 7459 7474 R00175; BPV1$BPV1_05; Binding factors: E2 . BS 7510 7525 R00176; BPV1$BPV1_06; Binding factors: E2 . BS 7588 7700 R00177; BPV1$BPV1_07; Binding factors: E2 . BS 7592 7607 R00178; BPV1$BPV1_08; Binding factors: E2 . BS 7594 7637 R00179; BPV1$BPV1_09; Binding factors: E2 . BS 7613 7639 R00180; BPV1$BPV1_10; Binding factors: E2 . BS 7621 7636 R00181; BPV1$BPV1_11; Binding factors: E2 . BS 7635 7650 R00182; BPV1$BPV1_12; Binding factors: E2 . BS 7637 7667 R00183; BPV1$BPV1_13; Binding factors: AP-2alphaA , BS AP-2alphaB . BS 7747 7840 R00184; BPV1$BPV1_14; Binding factors: E2 . BS 7761 7776 R00185; BPV1$BPV1_15; Binding factors: E2 . BS 7781 7796 R00186; BPV1$BPV1_16; Binding factors: E2 . BS 7896 7911 R00187; BPV1$BPV1_17; Binding factors: E2 . XX DR EMBL: J02045; PA1P. DR EMBL: X02346; PAPABPV1. DR TRANSPATH: G000040. XX RN [1] RX MEDLINE; 91208686. RA Li R., Knight J. D., Jackson S. P., Tijan R., Botchan M. R. RT Direct interaction between Sp1 and the BPV Enhancer E2 protein mediates RT synergistic activation of transcription RL Cell 65:493-505 (1991). RN [2] RX MEDLINE; 90169511. RA Stenlund A., Botchan M. R. RT The E2 trans-activator can act as a repressor by interfering with a RT cellular transcription factor RL Genes Dev. 4:123-136 (1990). RN [3] RX MEDLINE; 91012786. RA Vande Pol S. B., Howley P. M. RT A bovine papillomavirus constitutive enhancer is negatively regulated by RT the E2 repressor through competitive binding for a cellular factor RL J. Virol. 64:5420-5429 (1990). RN [4] RX MEDLINE; 89252826. RA Li R., Knight J., Bream G., Stenlund A., Botchan M. RT Specific recognition nucleotides and their DNA context determine the RT affinity of E2 protein for 17 binding sites in the BPV-1 genome RL Genes Dev. 3:510-526 (1989). RN [5] RX MEDLINE; 88211566. RA Hawley-Nelson P., Androphy E. J., Lowy D. R., Schiller J. T. RT The specific DNA recognition sequence of the bovine papillomavirus E2 RT protein is an E2-dependent enhancer RL EMBO J. 7:525-531 (1988). RN [6] RX MEDLINE; 88158086. RA Moskaluk C., Bastia D. RT DNA bending is induced in an enhancer by the DNA-binding domain of the RT bovine papillomavirus E2 protein RL Proc. Natl. Acad. Sci. USA 85:1826-1830 (1988). RN [7] RX MEDLINE; 88027009. RA Imagawa M., Chiu R., Karin M. RT Transcription factor AP-2 mediates induction by two different signal RT transduction pathways: Protein kinase C and cAMP RL Cell 51:251-260 (1987). RN [8] RX MEDLINE; 87147244. RA Moskaluk C., Bastia D. RT The E2 gene of bovine papillomavirus encodes an enhancer-binding protein RL Proc. Natl. Acad. Sci. USA 84:1215-1218 (1987). XX // AC G000041 XX ID CAMV$35SR XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD 35S RNA XX OS CaMV, cauliflower mosaic virus OC viridae; ds-DNA nonenveloped viruses; caulimovirus XX BC 6.1.1 XX BS empty empty R09529; CAMV$35SR_07; Binding factors: HRT . BS -276 -252 R03626; CAMV$35SR_05; Binding factors: MNF1 , MNB1a BS , MNB1b , OBP1 , OBP2 , OBP3 . BS -263 -239 R03627; CAMV$35SR_06; Binding factors: MNB1b . BS -141 -117 R01914; CAMV$35SR_02; Binding factors: HBP-1 . BS -89 -59 R01918; CAMV$35SR_04; Binding factors: OCSTF , MYBST1 BS , OBF3.1 , OBF3.2 . BS -88 -60 R01915; CAMV$35SR_03; Binding factors: HBP-1 , HBP-1a BS , HBP-1b , HBP-1b(c1) , HBP-1a(1) , BS HBP-1a(c14) . BS -83 -63 R00009; CAMV$35SR_01; Binding factors: TGA1a , TGA1b BS , OBF4 , OBF5 , TGA1 , TGA2 , TGA3 BS , TGA6 , ZAP1 , TGA2.1 , TGA2.2 , BS ASF-1 , SARP . XX DR EMBL: V00140; CAMVG1. DR EMBL: X14911; CAMVI. DR EMBL: L09053; MCAMIBP. DR EMBL: M32811; MCAMPX. DR TRANSPATH: G000041. XX RN [1] RX MEDLINE; 20267446. RA Niggeweg R., Thurow C., Weigel R., Pfitzner U., Gatz C. RT Tobacco TGA factors differ with respect to interaction with NPR1, RT activation potential and DNA-binding properties RL Plant Mol. Biol. 42:775-788 (2000). RN [2] RX MEDLINE; 20224028. RA Kang H. G., Singh K. B. RT Characterization of salicylic acid-responsive, arabidopsis Dof domain RT proteins: overexpression of OBP3 leads to growth defects RL Plant J. 21:329-339 (2000). RN [3] RX MEDLINE; 98389765. RA Raventos D., Skriver K., Schlein M., Karnahl K., Rogers S. W., Rogers J. RA C., Mundy J. RT HRT, a novel zinc finger, transcriptional repressor from barley RL J. Biol. Chem. 273:23313-23320 (1998). RN [4] RX MEDLINE; 97369364. RA Xiang C., Miao Z., Lam E. RT DNA-binding properties, genomic organization and expression pattern of RT TGA6, a new member of the TGA family of bZIP transcription factors in RT Arabidopsis thaliana. RL Plant Mol. Biol. 34:403-415 (1997). RN [5] RX MEDLINE; 96188845. RA de Pater S., Pham K., Memelink J., Kijne J. RT Binding specificity and tissue-specific expression pattern of the RT Arabidopsis bZIP transcription factor TGA2. RL Mol. Gen. Genet. 250:237-239 (1996). RN [6] RX MEDLINE; 97128253. RA de Pater S., Greco V., Pham K., Memelink J., Kijne J. RT Characterization of a zinc-dependent transcriptional activator from RT Arabidopsis RL Nucleic Acids Res. 24:4624-4631 (1996). RN [7] RX MEDLINE; 96017785. RA Lam E., Lam Y. K.-P. RT Binding site requirements and differential representation of TGA factors in RT nuclear ASF-1 activity RL Nucleic Acids Res. 23:3778-3785 (1995). RN [8] RX MEDLINE; 96351937. RA Zhang B., Chen W., Foley R. C., Buttner M., Singh K. B. RT Interactions between distinct types of DNA binding proteins enhance binding RT to ocs element promoter sequences RL Plant Cell 7:2241-2252 (1995). RN [9] RX MEDLINE; 95045433. RA Baranowskij N., Frohberg C., Prat S., Willmitzer L. RT A novel DNA binding protein with homology to Myb oncoproteins containing RT only one repeat can function as a transcriptional activator RL EMBO J. 13:5383-5392 (1994). RN [10] RX MEDLINE; 94272006. RA Miao Z.-H., Liu X., Lam E. RT TGA3 is a distinct member of the TGA family of bZIP transcription factors RT in Arabidopsis thaliana. RL Plant Mol. Biol. 25:1-11 (1994). RN [11] RX MEDLINE; 93340215. RA Yanagisawa S., Izui K. RT Molecular cloning of two DNA-binding proteins of maize that are RT structurally different but interact with the same sequence motif RL J. Biol. Chem. 268:16028-16036 (1993). RN [12] RX MEDLINE; 93386190. RA Foley R. C., Grossman C., Ellis J. G., Llewellyn D. J., Dennis E. S., RA Peacock W. J., Singh K. B. RT Isolation of a maize bZIP protein subfamily-candidates for the ocs-element RT transcription factor RL Plant J. 3:669-679 (1993). RN [13] RX MEDLINE; 93076114. RA Schindler U., Beckmann H., Cashmore A. R. RT TGA1 and G-box binding factors: two distinct classes of Arabidopsis leucine RT zipper proteins compete for the G-box-like element TGACGTGG. RL Plant Cell 4:1309-1319 (1992). RN [14] RX MEDLINE; 91224097. RA Tabata T., Nakayama T., Mikami K., Iwabuchi M. RT HBP-1a and HBP-1b: leucine zipper-type transcription factors of wheat RL EMBO J. 10:1459-1467 (1991). RN [15] RA Takase H., Tabata T., Mikami K., Iwabuchi M. RT Partial purification and characterization of two transcription factors, RT HBP-1a and HBP-1b, specific for a cis-acting element, ACGTCA, of wheat RT histone genes RL Plant Cell Physiol. 32:1195-1203 (1991). RN [16] RX MEDLINE; 90384943. RA Yamazaki K.-I., Katagiri F., Imaseki H., Chua N.-H. RT TGA1a, a tobacco DNA-binding protein, increases the rate of initiation in a RT plant in vitro transcription system RL Proc. Natl. Acad. Sci. USA 87:7035-7039 (1990). RN [17] RX MEDLINE; 90277686. RA Lam E., Katagiri F., Chua N.-H. RT Plant nuclear factor ASF-1 binds to an essential region of the nopaline RT synthase promoter RL J. Biol. Chem. 265:9909-9913 (1990). RN [18] RX MEDLINE; 90076142. RA Bouchez D., Tokuhisa T. G., Llewellyn D. J., Dennis E. S., Ellis J. G. RT The ocs-element is a component of the promoters of several T-DNA and plant RT viral genes RL EMBO J. 8:4197-4204 (1989). RN [19] RX MEDLINE; 89365179. RA Katagiri F., Lam E., Chua N.-H. RT Two tobacco DNA-binding proteins with homology to the nuclear factor CREB RL Nature 340:727-729 (1989). RN [20] RX MEDLINE; 89365179. RA Katagiri F., Lam E., Chua N.-H. RT Two tobacco DNA-binding proteins with homology to the nuclear factor CREB RL Nature 340:727-730 (1989). RN [21] RX MEDLINE; 90098838. RA Mikami K., Sakamoto A., Takase H., Tabata T., Iwabuchi M. RT Wheat nuclear protein HBP-1 binds to the hexameric sequence in the promoter RT of various plant genes RL Nucleic Acids Res. 17:9707-9717 (1989). RN [22] RX MEDLINE; 90046702. RA Lam E., Benfey P. N., Gilmartin P. M., Fang R.-X., Chua N.-H. RT Site-specific mutations alter in vitro factor binding and change promoter RT expression patterns in transgenic plants RL Proc. Natl. Acad. Sci. USA 86:7890-7894 (1989). XX // AC G000042 XX ID CHICK$ACRA XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD AChR alpha XX DE acetylcholine receptor, alpha-subunit XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.5.15 XX BS -132 -123 R00011; CHICK$ACRA_01. BS -110 -96 R00012; CHICK$ACRA_02; Binding factors: MyoD . BS -98 -90 R00013; CHICK$ACRA_03. BS -91 -74 R00014; CHICK$ACRA_04; Binding factors: MyoD . BS -87 -79 R00015; CHICK$ACRA_05; Binding factors: NF-1 (-like proteins) BS , Sp1 . BS -76 -68 R00016; CHICK$ACRA_06. BS -60 -38 R00017; CHICK$ACRA_07; Binding factors: Sp1 . XX DR EMBL: AF051909; AF051909. DR TRANSPATH: G000042. DR TRANSCOMPEL: C00010. DR TRANSCOMPEL: C00027. DR TRRD: 00343. XX RN [1] RX MEDLINE; 90259076. RA Piette J., Bessereau J.-L., Huchet M., Changeux J.-P. RT Two adjacent MyoD1-binding sites regulate expression of the acetylcholine RT receptor alpha-subunit gene RL Nature 345:353-358 (1990). RN [2] RX MEDLINE; 89251598. RA Piette J., Klarsfeld A., Changeux J.-P. RT Interaction of nuclear factors with the upstream region of the RT alpha-subunit gene of chicken muscle acetylcholine receptor: variations RT with muscle differentiation and denervation RL EMBO J. 8:687-694 (1989). XX // AC G000043 XX ID CHICK$ACC XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD C-ACT XX DE cardiac actin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.5.1 XX BS -177 -156 R03109; CHICK$ACC_03; Binding factors: E12 , MyoD BS , myogenin . BS -136 0 R01750; CHICK$ACC_01. BS -50 0 R01751; CHICK$ACC_02. XX DR EMBL: X00182; GGAC01. DR EMBL: M10607; GGACACA. DR EMBL: X02212; GGACTAC. DR TRANSPATH: G000043. XX RN [1] RX MEDLINE; 91203863. RA French B. A., Chow K.-L., Olson E. N., Schwartz R. J. RT Heterodimers of myogenic helix-loop-helix regulatory factors and E12 bind a RT complex element governing myogenic induction of the avian cardiac RT alpha-actin promoter RL Mol. Cell. Biol. 11:2439-2450 (1991). RN [2] RX MEDLINE; 90014775. RA Quitschke W. W., dePonti-Zilli L., Lin Z.-Y., Paterson B. M. RT Identification of Two Nuclear Factor-Binding Domains on the Chicken Cardiac RT Actin Promoter: Implications for Regulation of the Gene RL Mol. Cell. Biol. 9:3218-3230 (1989). XX // AC G000044 XX ID CHICK$AAC XX DT 14.06.1995 (created); dbo. DT 09.03.1998 (updated); ili. CO Copyright (C), Biobase GmbH. XX SD SA-ACT XX DE skeletal alpha-actin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.5.1 XX BS -186 -167 R03495; CHICK$AAC_09; Binding factors: SRF . BS -148 -12 R00029; CHICK$AAC_01; Binding factors: YY1 . BS -148 -12 R00030; CHICK$AAC_02; Binding factors: MAPF2 . BS -141 -122 R03496; CHICK$AAC_10; Binding factors: SRF . BS -100 -73 R09711; CHICK$AAC_12. BS -91 -81 R00031; CHICK$AAC_03; Binding factors: MF3 , SRF BS , SRF , SRF , YY1 . BS -83 -78 R00034; CHICK$AAC_06; Binding factors: F-ACT1 , delta BS factor , MAPF2 , YY1 , MAPF2 . BS -83 -78 R00035; CHICK$AAC_07; Binding factors: YY1 . BS -76 -28 R04885; CHICK$AAC_11; Binding factors: Sp1 , TEF-1 BS . BS -71 -50 R02075; CHICK$AAC_08; Binding factors: MCBF , MF3 BS . XX DR EMBL: M13631; GGACAREG. DR TRANSPATH: G000044. DR TRANSCOMPEL: C00008. DR TRRD: 00015. XX RN [1] RX MEDLINE; 96299437. RA Croissant J.D., Kim J.H., Eichele G., Goering L., Lough J., Prywes R., RA Schwartz R.J. RT Avian serum response factor expression restricted primarily to muscle cell RT lineages is required for alpha-actin gene transcription RL Dev. Biol. 177:250-264 (1996). RN [2] RX MEDLINE; 94266892. RA MacLellan W. R., Lee T.-C., Schwartz R. J., Schneider M. D. RT Transforming growth factor-beta response elements of the skeletal RT alpha-actin gene RL J. Biol. Chem. 269:16754-16760 (1994). RN [3] RX MEDLINE; 94158847. RA Raught B., Khursheed B., Kazansky A., Rosen J. RT YY1 represses beta-casein gene expression by preventing the formation of a RT lactation-associated complex RL Mol. Cell. Biol. 14:1752-1763 (1994). RN [4] RX MEDLINE; 92375089. RA Gualberto A., LePage D., Pons G., Mader S. L., Park K., Atchison M. L., RA Walsh K. RT Functional antagonism between YY1 and the serum response factor RL Mol. Cell. Biol. 12:4209-4214 (1992). RN [5] RX MEDLINE; 93028553. RA Lee T.-C., Shi Y., Schwartz R. J. RT Displacement of BrdUrd-induced YY1 by serum response factor activates RT skeletal alpha-actin transcription in embryonic myoblasts RL Proc. Natl. Acad. Sci. USA 89:9814-9818 (1992). RN [6] RX MEDLINE; 92017784. RA Lee T.-C., Chow K.-L., Fang P., Schwartz R. J. RT Activation of skeletal alpha-actin gene transcription: the cooperative RT formation of serum response factor-binding complexes over positive RT cis-acting promoter serum response elements displaces a negative-acting RT nuclear factor enriched in replicating a RL Mol. Cell. Biol. 11:5090-5100 (1991). RN [7] RX MEDLINE; 91172180. RA Santoro I. M., Yi T.-M., Walsh K. RT Identification of single-stranded-DNA-binding proteins that interact with RT muscle gene elements RL Mol. Cell. Biol. 11:1944-1953 (1991). RN [8] RX MEDLINE; 91260723. RA Ernst H., Walsh K., Harrison C. A., Rosenthal N. RT The myosin light chain enhancer and the skeletal actin promoter share a RT binding site for factors involved in muscle-specific gene expression RL Mol. Cell. Biol. 11:3735-3744 (1991). RN [9] RX MEDLINE; 92049360. RA Santoro I. M., Walsh K. RT Natural and synthetic DNA elements with the CArG motif differ in expression RT and protein-binding properties RL Mol. Cell. Biol. 11:6296-6305 (1991). RN [10] RX MEDLINE; 90318394. RA Mar J. H., Ordahl Ch. P. RT M-CAT Binding Factor, a Novel trans-Acting Factor Governing Muscle-Specific RT Transcription RL Mol. Cell. Biol. 10:4271-4283 (1990). RN [11] RX MEDLINE; 89313766. RA Walsh K. RT Cross-Binding of Factors to Functionally Different Promoter Elements in RT c-fos and Skeletal Actin Genes RL Mol. Cell. Biol. 9:2191-2201 (1989). RN [12] RX MEDLINE; 88246451. RA Walsh K., Schimmel P. RT DNA-binding site for two skeletal actin promoter factors is important for RT expression in muscle cells RL Mol. Cell. Biol. 8:1800-1802 (1988). RN [13] RX MEDLINE; 87250597. RA Walsh K., Schimmel P. RT Two Nuclear Factors Compete for the Skeletal Muscle Actin Promoter RL J. Biol. Chem. 262:9429-9432 (1987). XX // AC G000045 XX ID CHICK$AACR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CRY-alphaA XX DE alphaA-crystallin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.9 XX BS -156 -131 R02662; CHICK$AACR_01. XX DR EMBL: M30595; GGAAX. DR EMBL: X03005; GGACRYG1. XX RN [1] RX MEDLINE; 90062087. RA Klement J. F., Wawrousek E. F., Piatigorsky J. RT Tissue-specific Expression of the Chicken alphaA-Crystallin Gene in RT Cultured Lens Epithelia and Transgenic Mice RL J. Biol. Chem. 264:19837-19844 (1989). XX // AC G000046 XX ID CHICK$AAG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-AA XX DE alphaA-globin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.3.10.2 XX BS 1405 1414 R00513; CHICK$AAG_07; Binding factors: GATA-1 . BS 1459 1473 R00514; CHICK$AAG_08; Binding factors: GATA-1 . BS 1514 1528 R00515; CHICK$AAG_09; Binding factors: GATA-1 . XX DR EMBL: X08022; GGGLAA3. DR TRANSPATH: G000046. DR SMARTDB: SM0000077. DR SMARTDB: SM0000078. DR SMARTDB: SM0000233. DR SMARTDB: SM0000235. DR TRRD: 00003. XX RN [1] RX MEDLINE; 89261753. RA Knezetic J. A., Felsenfeld G. RT Identification and Characterization of a Chicken alpha-Globin Enhancer RL Mol. Cell. Biol. 9:893-901 (1989). XX // AC G000047 XX ID CHICK$ADG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-AD XX DE alphaD-globin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.3.10.2 XX BS -73 -66 R00516; CHICK$ADG_01. BS -71 -52 R00517; CHICK$ADG_02. BS -63 -55 R00518; CHICK$ADG_03; Binding factors: GATA-1 . BS -53 -38 R00519; CHICK$ADG_04. XX DR EMBL: X59989; GGAAAD. DR EMBL: V00411; GGGL04. DR TRANSPATH: G000047. DR SMARTDB: SM0000077. DR SMARTDB: SM0000078. DR SMARTDB: SM0000233. DR SMARTDB: SM0000235. DR TRRD: 00428. XX RN [1] RX MEDLINE; 96189105. RA Trainor C. D., Omichinski J. G., Vandergon T. L., Gronenborn A. M., Clore RA G. M., Felsenfeld G. RT A palindromic regulatory site within vertebtrate GATA-1 promoters requires RT both zinc fingers of the GATA-1 DNA-binding domain for high-affinity RT interaction RL Mol. Cell. Biol. 16:2238-2247 (1996). RN [2] RX MEDLINE; 91117251. RA Evans T., Felsenfeld G. RT trans-activation of a globin promoter in nonerythroid cells RL Mol. Cell. Biol. 11:843-853 (1991). RN [3] RX MEDLINE; 89261753. RA Knezetic J. A., Felsenfeld G. RT Identification and Characterization of a Chicken alpha-Globin Enhancer RL Mol. Cell. Biol. 9:893-901 (1989). RN [4] RX MEDLINE; 87257917. RA Kemper B., Jackson P. D., Felsenfeld G. RT Protein-Binding Sites within the 5' DNase I-Hypersensitive Region of the RT Chicken alphaD-Globin Gene RL Mol. Cell. Biol. 7:2059-2069 (1987). XX // AC G000048 XX ID CHICK$APOVLDL XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD apoVLDL II XX DE apo very low density lipoprotein XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.3.3 XX BS -2592 -2583 R02598; CHICK$APOVLDL_06; Binding factors: C/EBPalpha BS . BS -283 -234 R02949; CHICK$APOVLDL_07. BS -222 -198 R00153; CHICK$APOVLDL_01; Binding factors: ER-alpha . BS -186 -165 R00154; CHICK$APOVLDL_02; Binding factors: ER-alpha . BS -165 -144 R02950; CHICK$APOVLDL_08; Binding factors: C/EBPalpha BS . BS -140 -129 R00155; CHICK$APOVLDL_03; Binding factors: LF-A1 . BS -97 -62 R00156; CHICK$APOVLDL_04; Binding factors: C/EBPalpha . BS -69 -40 R00157; CHICK$APOVLDL_05; Binding factors: COUP , BS LF-A1 . XX DR EMBL: J00810; GGAPOLP2. DR EMBL: V00448; GGVL01. DR TRANSPATH: G000048. DR TRRD: 00146. XX RN [1] RX MEDLINE; 91187646. RA Wijnholds J., Muller E., Ab G. RT Oestrogen facilitates the binding of ubiquitous and liver-enriched nuclear RT proteins to the apoVLDL II promoter in vivo RL Nucleic Acids Res. 19:33-41 (1991). RN [2] RX MEDLINE; 92020230. RA Beekman J. M., Wijnholds J., Schippers I. J., Pot W., Gruber M., Ab G. RT Regulatory elements and DNA-binding proteins mediating transcription from RT the chicken very-low-density apolipoprotein II gene RL Nucleic Acids Res. 19:5371-5377 (1991). RN [3] RX MEDLINE; 90097823. RA Hoodless P. A., Roy R. N., Ryan A. K., Hache R. J. G., Vasa M. Z., Deeley RA R. G. RT Developmental Regulation of Specific Protein Interactions with an RT Enhancerlike Binding Site Far Upstream from the Avian Very-Low-Density RT Apolipoprotein II Gene RL Mol. Cell. Biol. 10:154-164 (1990). RN [4] RX MEDLINE; 89030640. RA Wijnholds J., Philipsen J. N. J., Ab G. RT Tissue-specific and steroid-dependent interaction of transcription factors RT with the oestrogen-inducible apoVLDL II promoter in vivo RL EMBO J. 7:2757-2763 (1988). XX // AC G000049 XX ID CHICK$BAC XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD B-ACT XX DE beta-actin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.5.1 XX BS -238 -218 R00042; CHICK$BAC_01; Binding factors: ETF . BS -170 -154 R00043; CHICK$BAC_02; Binding factors: ETF . BS -155 -112 R02639; CHICK$BAC_06; Binding factors: GCF . BS -144 -128 R00044; CHICK$BAC_03; Binding factors: ETF . BS -140 0 R02640; CHICK$BAC_07; Binding factors: ETF . BS -127 -111 R00045; CHICK$BAC_04; Binding factors: ETF . BS -30 0 R00046; CHICK$BAC_05; Binding factors: ETF . XX DR EMBL: X00182; GGAC01. DR TRANSPATH: G000049. XX RN [1] RX MEDLINE; 90075226. RA Kageyama R., Pastan I. RT Molecular Cloning and Characterization of a Human DNA Binding Factor That RT Represses Transcription RL Cell 59:815-825 (1989). RN [2] RX MEDLINE; 89359391. RA Kageyama R., Merlino G. T., Pastan I. RT Nuclear Factor ETF Specifically Stimulates Transcription from Promoters RT without a TATA Box RL J. Biol. Chem. 264:15508-15514 (1989). XX // AC G000050 XX ID CHICK$BG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-B XX DE beta-globin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.3.9.3 XX BS -102 -95 R01943; CHICK$BG_01; Binding factors: TFIID . BS -37 -24 R01944; CHICK$BG_02; Binding factors: GATA-1 , GATA-1 BS , TBP , TFIID . BS 1826 1839 R01945; CHICK$BG_03; Binding factors: TGGCA-binding protein BS . BS 1852 1858 R01946; CHICK$BG_04; Binding factors: AP-1 , NF-E2 BS , MafK , NF-E2 p45 , Bach1 , Bach2 BS , Bach1 . BS 1864 1871 R01947; CHICK$BG_05; Binding factors: AP-2 . BS 1879 1886 R01948; CHICK$BG_06. BS 1898 1930 R01949; CHICK$BG_07; Binding factors: GATA-1 . BS 1995 0 R01950; CHICK$BG_08; Binding factors: NF-E4 . XX DR EMBL: X04522; GGBGLENH. DR EMBL: V00409; GGGL02. DR EMBL: M12890; GGHBBAB. DR TRANSPATH: G000050. XX RN [1] RX MEDLINE; 21269257. RA Kanezaki R., Toki T., Yokoyama M., Yomogida K., Sugiyama K., Yamamoto M., RA Igarashi K., Ito E. RT Transcription factor BACH1 is recruited to the nucleus by its novel RT alternative spliced isoform RL J. Biol. Chem. 276:7278-7284 (2001). RN [2] RX MEDLINE; 21280805. RA Ogawa K., Sun J., Taketani S., Nakajima O., Nishitani C., Sassa S., Hayashi RA N., Yamamoto M., Shibahara S., Fujita H., Igarashi K. RT Heme mediates derepression of Maf recognition element through direct RT binding to transcription repressor Bach1 RL EMBO J. 20:2835-2843 (2001). RN [3] RX MEDLINE; 97042438. RA Oyake T., Itoh K., Motohashi H., Hayashi N., Hoshino H., Nishizawa M., RA Yamamoto M., Igarashi K. RT Bach proteins belong to a novel family of BTB-basic leucine zipper RT transcription factors that interact with MafK and regulate transcription RT through the NF-E2 site RL Mol. Cell. Biol. 16:6083-6095 (1996). RN [4] RX MEDLINE; 95221427. RA Igarashi K., Itoh K., Motohashi H., Hayashi N., Matuzaki Y., Nakauchi H., RA Nishizawa M., Yamamoto M. RT Activity and expression of murine small Maf family protein MafK RL J. Biol. Chem. 270:7615-7624 (1995). RN [5] RX MEDLINE; 94117501. RA Aird W. C., Parvin J. D., Sharp P. A., Rosenberg R. D. RT The interaction of GATA-binding proteins and basal transcription factors RT with GATA box-containing core promoters. A model of tissue-specific gene RT expression RL J. Biol. Chem. 269:883-889 (1994). RN [6] RA Fong T. C., Emerson B. M. RT The erythroid-specific protein cGATA-1 mediates distal enhancer activity RT through a specialized beta-globin TATA box RL Genes Dev. 6:521-532 (1992). RN [7] RX MEDLINE; 90152332. RA Gallarda J. L., Foley K. P., Yang Z., Engel J. D. RT The beta-globin stage selector element factor is erythroid-specific RT promoter/enhancer binding protein NF-E4 RL Genes Dev. 3:1845-1859 (1989). XX // AC G000051 XX ID CHICK$BAG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-BA XX DE betaA-globin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.3.9.2 XX BS -201 -177 R00527; CHICK$BAG_01; Binding factors: BGP1 , G BS factor . BS -196 -176 R00528; CHICK$BAG_02; Binding factors: Sp1 . BS -162 -129 R00529; CHICK$BAG_03. BS -161 -137 R00530; CHICK$BAG_04. BS -161 -137 R02009; CHICK$BAG_09; Binding factors: CTF . BS -138 -129 R00531; CHICK$BAG_05; Binding factors: CACCC-binding factor BS . BS -138 -109 R02010; CHICK$BAG_10; Binding factors: Sp1 . BS -120 -110 R02011; CHICK$BAG_11; Binding factors: PPYR . BS -73 -65 R00532; CHICK$BAG_06; Binding factors: TGGCA-binding protein BS . BS -57 -39 R02012; CHICK$BAG_12; Binding factors: PPUR . BS -57 -39 R02013; CHICK$BAG_13; Binding factors: Sp1 . BS -50 -42 R00533; CHICK$BAG_07. BS -35 -25 R02014; CHICK$BAG_14; Binding factors: TFIID . BS 1892 1906 R00534; CHICK$BAG_08; Binding factors: GATA-1 , BS GATA-1 , GATA-3 , NF-E1b . XX DR EMBL: X04522; GGBGLENH. DR EMBL: V00409; GGGL02. DR EMBL: J00857; GGHBBA. DR EMBL: M12890; GGHBBAB. DR EMBL: M11252; GGJW101. DR TRANSPATH: G000051. DR TRRD: 00442. XX RN [1] RX MEDLINE; 91065513. RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D. RT Activity and tissue-specific expression of the transcription factor NF-E1 RT multigene family RL Genes Dev. 4:1650-1662 (1990). RN [2] RX MEDLINE; 90114418. RA Trainor C. D., Evans T., Felsenfeld G., Boguski M. S. RT Structure and evolution of a human erythroid transcription factor RL Nature 343:92-96 (1990). RN [3] RX MEDLINE; 90384810. RA Clark S. P., Lewis C. D., Felsenfeld G. RT Properties of BGP1, a poly(dG)-binding protein from chicken erythrocytes RL Nucleic Acids Res. 18:5119 (1990). RN [4] RX MEDLINE; 89288320. RA Emerson B. M., Nickol J. M., Fong T. C. RT Erythroid-specific activation and derepression of the chick beta-globin RT promoter in vitro RL Cell 57:1189-1200 (1989). RN [5] RX MEDLINE; 90152333. RA Jackson P. D., Evans T., Nickol J. M., Felsenfeld G. RT Developmental modulation of protein binding to beta-globin gene regulatory RT sites within chicken erythrocyte nuclei RL Genes Dev. 3:1860-1873 (1989). RN [6] RX MEDLINE; 90152332. RA Gallarda J. L., Foley K. P., Yang Z., Engel J. D. RT The beta-globin stage selector element factor is erythroid-specific RT promoter/enhancer binding protein NF-E4 RL Genes Dev. 3:1845-1859 (1989). RN [7] RX MEDLINE; 89064803. RA Rupp R. A. W., Nicolas R. H., Borgmeyer U., Lobanenkov V. V., Plumb M. A., RA Sippel A. E., Goodwin G. H. RT TGGCA protein is present in erythroid nuclei and binds within the RT nuclease-hypersensitive sites 5' of the chicken betaH- and betaA-globin RT genes RL Eur. J. Biochem. 177:505-511 (1988). RN [8] RX MEDLINE; 88320366. RA Evans T., Reitman M., Felsenfeld G. RT An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence RT common to all chicken globin genes RL Proc. Natl. Acad. Sci. USA 85:5976-5980 (1988). RN [9] RX MEDLINE; 87040733. RA Plumb M. A., Lobanenkov V. V., Nicolas R. H., Wright C. A., Zavou S., RA Goodwin G. H. RT Characterization of chicken erythroid nuclear proteins which bind to the RT nuclease hypersensitive regions upstream of betaA- and betaH-globin genes RL Nucleic Acids Res. 14:7675-7693 (1986). RN [10] RX MEDLINE; 85201671. RA Emerson B. M., Lewis C. D., Felsenfeld G. RT Interaction of specific nuclear factors with the nuclease-hypersensitive RT region of the chicken adult beta-globin gene: nature of the binding domain RL Cell 41:21-30 (1985). XX // AC G000052 XX ID CHICK$BB1CR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CRY-betB1 XX DE betaB1-crystallin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.9 XX BS -128 -112 R03011; CHICK$BB1CR_01. BS -116 -102 R03012; CHICK$BB1CR_02; Binding factors: PEA1 , PEA2 BS . BS -92 -73 R03013; CHICK$BB1CR_03; Binding factors: PEA1 , PEA2 BS . BS -77 -62 R03014; CHICK$BB1CR_04; Binding factors: POU2F1 . XX DR EMBL: M63906; GGBB1CRY. DR TRANSPATH: G000052. DR TRRD: 00176. XX RN [1] RX MEDLINE; 91141498. RA Roth H. J., Das G. C., Piatigorsky J. RT Chicken betaB1-crystallin gene expression: presence of conserved functional RT polyomavirus enhancer-like and octamer binding-like promoter elements found RT in non-lens genes RL Mol. Cell. Biol. 11:1488-1499 (1991). XX // AC G000053 XX ID CHICK$BHG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-BH XX DE betaH-globin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.3.10.3 XX BS 409 430 R00535; CHICK$BHG_01. BS 437 448 R00536; CHICK$BHG_02; Binding factors: GATA-1 . BS 483 499 R00537; CHICK$BHG_03; Binding factors: TGGCA-binding protein BS . BS 500 522 R00538; CHICK$BHG_04; Binding factors: GATA-1 . BS 569 580 R00539; CHICK$BHG_05; Binding factors: GATA-1 . XX DR EMBL: X13142; GGBGLH5. DR TRANSPATH: G000053. DR TRRD: 00423. XX RN [1] RX MEDLINE; 89160297. RA Perkins N. D., Nicolas R. H., Plumb M. A., Goodwin G. H. RT The purification of an erythroid protein which binds to enhancer and RT promoter elements of haemoglobin genes RL Nucleic Acids Res. 17:1299-1314 (1989). RN [2] RX MEDLINE; 89064803. RA Rupp R. A. W., Nicolas R. H., Borgmeyer U., Lobanenkov V. V., Plumb M. A., RA Sippel A. E., Goodwin G. H. RT TGGCA protein is present in erythroid nuclei and binds within the RT nuclease-hypersensitive sites 5' of the chicken betaH- and betaA-globin RT genes RL Eur. J. Biochem. 177:505-511 (1988). RN [3] RX MEDLINE; 87040733. RA Plumb M. A., Lobanenkov V. V., Nicolas R. H., Wright C. A., Zavou S., RA Goodwin G. H. RT Characterization of chicken erythroid nuclear proteins which bind to the RT nuclease hypersensitive regions upstream of betaA- and betaH-globin genes RL Nucleic Acids Res. 14:7675-7693 (1986). XX // AC G000054 XX ID CHICK$CA2 XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD CAII XX DE carbonic anhydrase II XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.4 XX BS -1203 -1187 R10023; CHICK$CA2_02; Binding factors: VDR , BS RXR-alpha . BS -667 -654 R04090; CHICK$CA2_01; Binding factors: v-ErbA , BS T3R-alpha . XX DR EMBL: X06000; GGCAII12. DR TRANSPATH: G000054. DR BRENDA: 4.2.1.1. XX RN [1] RX MEDLINE; 95110436. RA Quelo I., Kahlen J. P., Rascle A., Jurdic P., Carlberg C. RT Identification and characterization of a vitamin D3 response element of RT chicken carbonic anhydrase-II RL DNA Cell Biol. 13:1181-1187 (1994). RN [2] RX MEDLINE; 92038993. RA Disela C., Glineur C., Bugge T., Sap J., Stengl G., Dodgson J., Stunnenberg RA H., Beug H., Zenke M. RT v-erbA overexpression is required to extinguish c-erbA function in RT erythroid cell differentiation annd regulation of the erbA target gene CAII RL Genes Dev. 5:2033-2047 (1991). XX // AC G000055 XX ID CHICK$HOX14 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Chox-1.4 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BS empty empty R00215; CHICK$HOX14_01; Binding factors: HOXA4 . BS empty empty R00216; CHICK$HOX14_02; Binding factors: HOXA4 . XX DR EMBL: X52670; GGCHOX14. DR TRANSPATH: G000055. XX RN [1] RX MEDLINE; 90245562. RA Sasaki H., Yokoyama E., Kuroiwa A. RT Specific DNA binding of the two chicken Deformed family homeodomain RT proteins, Chox-1.4 and Chox-a RL Nucleic Acids Res. 18:1739-1747 (1990). XX // AC G000056 XX ID CHICK$CHOXA XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Chox-a XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BS empty empty R00217; CHICK$CHOXA_01; Binding factors: HOXA4 . BS empty empty R00218; CHICK$CHOXA_02; Binding factors: HOXA4 . BS empty empty R00219; CHICK$CHOXA_03; Binding factors: HOXA4 . BS empty empty R00220; CHICK$CHOXA_04; Binding factors: HOXA4 . BS empty empty R00221; CHICK$CHOXA_05; Binding factors: HOXA4 . BS empty empty R00222; CHICK$CHOXA_06; Binding factors: HOXA4 . XX DR EMBL: X52672; GGCHOXA. DR TRANSPATH: G000056. XX RN [1] RX MEDLINE; 90245562. RA Sasaki H., Yokoyama E., Kuroiwa A. RT Specific DNA binding of the two chicken Deformed family homeodomain RT proteins, Chox-1.4 and Chox-a RL Nucleic Acids Res. 18:1739-1747 (1990). XX // AC G000057 XX ID CHICK$CTNT XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD cTNT XX DE cardiac troponin T XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.5.4 XX BS -247 -215 R03070; CHICK$CTNT_04; Binding factors: CEBF . BS -226 -199 R03586; CHICK$CTNT_05; Binding factors: MEF-2 , MEF-2 BS , aMEF-2 , MEF-2 (516 AA) . BS -129 -110 R02072; CHICK$CTNT_01. BS -103 -85 R02073; CHICK$CTNT_02; Binding factors: MCBF . BS -81 -61 R02074; CHICK$CTNT_03; Binding factors: MCBF . XX DR EMBL: M57905; GDCTNT. DR TRANSPATH: G000057. DR TRRD: 00310. XX RN [1] RX MEDLINE; 92387551. RA Yu Y.-T., Breitbart R. E., Smoot L. B., Lee Y., Mahdavi V., Nadal-Ginard B. RT Human myocyte-specific enhancer factor 2 comprises a group of RT tissue-restricted MADS box transcription factors RL Genes Dev. 6:1783-1798 (1992). RN [2] RX MEDLINE; 91131641. RA Iannello R. C., Mar J. H., Ordahl C. P. RT Characterization of a promoter element required for transcription in RT myocardial cells RL J. Biol. Chem. 266:3309-3316 (1991). RN [3] RX MEDLINE; 90318394. RA Mar J. H., Ordahl Ch. P. RT M-CAT Binding Factor, a Novel trans-Acting Factor Governing Muscle-Specific RT Transcription RL Mol. Cell. Biol. 10:4271-4283 (1990). XX // AC G000058 XX ID CHICK$D1CR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CRY-delta1 XX DE delta1-crystallin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.9 XX BS -120 23 R00252; CHICK$D1CR_01; Binding factors: Sp1 . BS 2028 2082 R03376; CHICK$D1CR_02; Binding factors: deltaEF1 . BS 2060 2071 R08522; CHICK$D1CR_04; Binding factors: deltaEF2 . BS 2060 2071 R08525; CHICK$D1CR_05; Binding factors: POU2F1 . BS 2074 2079 R08520; CHICK$D1CR_03; Binding factors: deltaEF1 . XX DR EMBL: X02222; GGCRYD1. DR TRANSPATH: G000058. DR TRANSCOMPEL: C00013. DR TRRD: 00177. XX RN [1] RX MEDLINE; 93360957. RA Kamachi Y., Kondoh H. RT Overlapping positive and negative regulatory elements determine RT lens-specific activity of the delta1-crystallin enhancer RL Mol. Cell. Biol. 13:5206-5215 (1993). RN [2] RX MEDLINE; 91305095. RA Funahashi J.-i., Kamachi Y., Goto K., Kondoh H. RT Identification of nuclear factor deltaEF1 and its binding site essential RT for lens-specific activity of the delta1-crystallin enhancer RL Nucleic Acids Res. 19:3543-3547 (1991). RN [3] RX MEDLINE; 90239012. RA Alemany J., Borras T., de Pablo F. RT Transcriptional stimulation of the sigma1-crystallin gene by insulin-like RT growth factor I and insulin requires DNA cis elements in chicken RL Proc. Natl. Acad. Sci. USA 87:3353-3357 (1990). XX // AC G000059 XX ID CHICK$AGE XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD embryo AG XX DE embryonic alpha-globin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.3.9 XX DR TRANSCOMPEL: C00001. DR TRANSCOMPEL: C00005. DR TRANSCOMPEL: C00006. XX // AC G000060 XX ID CHICK$GATA1 XX DT 14.06.1995 (created); dbo. DT 20.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GATA1 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.2.4 XX BS -643 -634 R03087; CHICK$GATA1_01; Binding factors: GATA-1 . BS -592 -572 R03088; CHICK$GATA1_02. BS -568 -555 R03089; CHICK$GATA1_03. BS -485 -471 R03090; CHICK$GATA1_04. BS -442 -429 R03091; CHICK$GATA1_05. BS -409 -389 R03092; CHICK$GATA1_06. BS -373 -349 R03093; CHICK$GATA1_07; Binding factors: GATA-1 . BS -257 -239 R03094; CHICK$GATA1_08. BS -235 -221 R03095; CHICK$GATA1_09. BS -177 -157 R03096; CHICK$GATA1_10. BS -153 -137 R03097; CHICK$GATA1_11. BS -121 -102 R03098; CHICK$GATA1_12. BS -59 -49 R03099; CHICK$GATA1_13. XX DR EMBL: M59937; GGGATA1. DR TRANSPATH: G000060. DR TRRD: 00325. XX RN [1] RX MEDLINE; 96189105. RA Trainor C. D., Omichinski J. G., Vandergon T. L., Gronenborn A. M., Clore RA G. M., Felsenfeld G. RT A palindromic regulatory site within vertebtrate GATA-1 promoters requires RT both zinc fingers of the GATA-1 DNA-binding domain for high-affinity RT interaction RL Mol. Cell. Biol. 16:2238-2247 (1996). RN [2] RA Alam J., Zhining D. RT Distal AP-1 binding sites mediate basal level enhancement nad TPA induction RT of the mouse heme oxygenase-1 gene RL J. Biol. Chem. 267:21894-21900 (1992). RN [3] RX MEDLINE; 91195279. RA Hannon R., Evans T., Felsenfeld G., Gould H. RT Structure and promoter activity of the gene for the erythroid transcription RT factor GATA-1 RL Proc. Natl. Acad. Sci. USA 88:3004-3008 (1991). XX // AC G000061 XX ID CHICK$H1C XX DT 21.05.1996 (created); ake. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H1-c XX DE histone 1-c XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.1.1 XX DR TRRD: 00098. XX // AC G000062 XX ID CHICK$H2B XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H2B XX DE histone 2B XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.1.3 XX BS -59 -35 R00664; CHICK$H2B_01; Binding factors: POU2F1 . XX DR EMBL: J00864; GGH2A2B. DR EMBL: X07762; GGH2AB7. DR EMBL: X05095; GGH2B2. DR TRANSPATH: G000062. XX RN [1] RX MEDLINE; 89091990. RA Baumruker T., Sturm R., Herr W. RT OBP100 binds remarkably degenerate octamer motifs through specific RT interactions with flanking sequences RL Genes Dev. 2:1400-1413 (1988). XX // AC G000063 XX ID CHICK$H5 XX DT 21.05.1996 (created); ake. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H5 XX DE histone 5 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.1.1 XX BS -2158 -2144 R08218; CHICK$H5_08. BS -2130 -2115 R08219; CHICK$H5_09; Binding factors: GATA-1 . BS -2090 -2073 R08220; CHICK$H5_10; Binding factors: GATA-1 , NF-1 BS (-like proteins) . BS -2090 -2060 R08235; CHICK$H5_25. BS -2065 -2036 R08221; CHICK$H5_11; Binding factors: GATA-1 . BS -2022 -2007 R08222; CHICK$H5_12; Binding factors: GATA-1 . BS -1982 -1968 R08223; CHICK$H5_13. BS -1287 -1251 R08224; CHICK$H5_14; Binding factors: BGP1 . BS -1184 -1171 R08225; CHICK$H5_15; Binding factors: GATA-1 . BS -170 -148 R08211; CHICK$H5_01; Binding factors: Sp1 . BS -120 -103 R08212; CHICK$H5_02. BS -95 -75 R08213; CHICK$H5_03; Binding factors: Sp1 . BS -73 -58 R08214; CHICK$H5_04. BS -55 -46 R08215; CHICK$H5_05; Binding factors: H4TF-2 . BS -37 -25 R08216; CHICK$H5_06; Binding factors: Sp1 . BS -15 8 R08217; CHICK$H5_07; Binding factors: IBR , IBF BS . BS 926 937 R08226; CHICK$H5_16. BS 948 964 R08227; CHICK$H5_17; Binding factors: Sp1 . BS 987 1009 R08228; CHICK$H5_18; Binding factors: Sp1 . BS 1047 1058 R08229; CHICK$H5_19; Binding factors: GATA-1 . BS 1082 1095 R08230; CHICK$H5_20. BS 1112 1139 R08231; CHICK$H5_21; Binding factors: NF-1 (-like proteins) BS . BS 1163 1191 R08232; CHICK$H5_22; Binding factors: NF-1 (-like proteins) BS . BS 1208 1240 R08233; CHICK$H5_23. BS 1249 1267 R08234; CHICK$H5_24. XX DR EMBL: X00169; GGHI03. DR TRANSPATH: G000063. DR SMARTDB: SM0000173. DR TRRD: 00099. XX RN [1] RX MEDLINE; 93330285. RA Rousseau S., Asselin M., Renaud J., Ruiz-Carrillo A. RT Transcription of the histone H5 gene is regulated by three RT differentiation-specific enhancers. RL Mol. Cell. Biol. 13:4904-4917 (1993). RN [2] RX MEDLINE; 94009625. RA Sun J.-M., Penner C. G., Davie J. R. RT Repression of histone H5 gene expression in chicken mature erythrocytes is RT correlated with reduced DNA-binding activities of transcription factors Sp1 RT and GATA-1. RL FEBS Lett. 331:141-144 (1993). RN [3] RX MEDLINE; 92258395. RA Gomez-Cuadrado A., Rousseau S., Renaud J., Ruiz-Carrillo A. RT Repression of the H5 histone gene by a factor from erythrocytes that binds RT to the region of transcription initiation RL EMBO J. 11:1857-1866 (1992). RN [4] RX MEDLINE; 90016808. RA Rousseau S., Renaud J., Ruiz-Carrillo A. RT Basal expression of the histone H5 gene is controlled by positive and RT negative cis-acting sequences. RL Nucleic Acids Res. 17:7495-7511 (1989). XX // AC G000064 XX ID CHICK$LYS XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD LYS XX DE lysozyme XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.4.8 XX BS -6100 0 R04481; CHICK$LYS_27; Binding factors: C/EBPbeta . BS -2676 -2657 R02580; CHICK$LYS_16; Binding factors: AP-1 . BS -2653 -2635 R02581; CHICK$LYS_17. BS -2620 -2602 R02582; CHICK$LYS_18; Binding factors: AP-1 . BS -2596 -2577 R02583; CHICK$LYS_19; Binding factors: C/EBPalpha , BS AP-3 . BS -2573 -2556 R02584; CHICK$LYS_20; Binding factors: C/EBPalpha , BS POU2F1 , AP-3 . BS -2409 -2360 R01672; CHICK$LYS_14; Binding factors: NeP1 . BS -2362 -2327 R01673; CHICK$LYS_15; Binding factors: T3R-alpha , BS T3R-beta1 , v-ErbA , RXR-beta , RXR-alpha , BS T3R-alpha . BS -2136 -2113 R00973; CHICK$LYS_01; Binding factors: GR , GR alpha BS , PR , PR A , GR beta . BS -2104 -2081 R00974; CHICK$LYS_02; Binding factors: GR , GR alpha BS , PR , PR A , GR beta . BS -2066 -2031 R00975; CHICK$LYS_03; Binding factors: GR , GR alpha BS , PR , PR A , GR beta . BS -2003 -1966 R00976; CHICK$LYS_04; Binding factors: PR , PR A BS . BS -1988 -1968 R00977; CHICK$LYS_05; Binding factors: GR . BS -1965 -1888 R00978; CHICK$LYS_06; Binding factors: PR , PR A BS . BS -1965 -1877 R00979; CHICK$LYS_07; Binding factors: GR . BS -208 -190 R02585; CHICK$LYS_21; Binding factors: C/EBPalpha , BS AP-3 . BS -202 -171 R00980; CHICK$LYS_08; Binding factors: GR . BS -202 -160 R00981; CHICK$LYS_09; Binding factors: PR B , PR A BS . BS -200 -174 R00982; CHICK$LYS_10; Binding factors: GR . BS -200 -160 R00983; CHICK$LYS_11; Binding factors: PR B . BS -192 -180 R02586; CHICK$LYS_22; Binding factors: NRD I . BS -175 -155 R02587; CHICK$LYS_23; Binding factors: C/EBPalpha , BS AP-3 . BS -146 -125 R02588; CHICK$LYS_24; Binding factors: C/EBPalpha , BS TGGCA-binding protein , AP-3 . BS -125 -93 R02589; CHICK$LYS_25; Binding factors: C/EBPalpha , BS AP-3 . BS -90 -74 R02590; CHICK$LYS_26; Binding factors: Sp1 . BS -80 -49 R00984; CHICK$LYS_12; Binding factors: GR . BS -80 -54 R00985; CHICK$LYS_13; Binding factors: GR , PR B BS . XX DR EMBL: X05461; GGLYE1. DR EMBL: X05463; GGLYE3. DR EMBL: X12509; GGLYSHRE. DR EMBL: V00429; GGLYSX. DR TRANSPATH: G000064. DR SMARTDB: SM0000031. DR SMARTDB: SM0000049. DR TRRD: 00076. XX RN [1] RX MEDLINE; 94117503. RA Yen P. M., Ikeda M., Brubaker J. H., Forgione M., Sugawara A., Chin W. W. RT Roles of v-erbA homodimers and heterodimers in mediating dominant negative RT activity by v-erbA RL J. Biol. Chem. 269:903-909 (1994). RN [2] RX MEDLINE; 95074177. RA Goethe R., Phi van L. RT The far upstream chicken lysozyme enhancer at -6.1 kilobase, by interacting RT with NF-M, mediates lipopolysaccharide-induced expression of the chicken RT lysozyme gene in chicken myelomonocytic cells RL J. Biol. Chem. 269:31302-31309 (1994). RN [3] RX MEDLINE; 94117446. RA Suen C.-S., Yen P. M., Chin W. W. RT In vitro transcriptional studies of the roles of the thyroid hormone (T3) RT response elements and minimal promoters in T3-stimulated gene transcription RL J. Biol. Chem. 269:1314-1322 (1994). RN [4] RX MEDLINE; 90242396. RA Baniahmad A., Steiner C., Koehne A. C., Renkawitz R. RT Modular structure of a chicken lysozyme silencer: involvement of an unusual RT thyroid hormone receptor binding site RL Cell 61:505-514 (1990). RN [5] RX MEDLINE; 89345064. RA Altschmied J., Muller M., Baniahmad A., Steiner C., Renkawitz R. RT Cooperative interaction of chicken lysozyme enhancer sub-domain partially RT overlapping with a steroid receptor binding site RL Nucleic Acids Res. 17:4975 (1989). RN [6] RX MEDLINE; 88328995. RA Hecht A., Berkenstam A., Stroemstedt P.-E., Gustafsson J.-A., Sippel A. E. RT A progesterone responsive element maps to the far upstream steroid DNase RT hypersensitive site of chicken lysozyme chromatin RL EMBO J. 7:2063-2073 (1988). RN [7] RX MEDLINE; 86206046. RA von der Ahe D., Renoir J.-M., Buchou T., Baulieu E.-E., Beato M. RT Receptors for glucocorticosteroid and progesterone recognize distinct RT features of a DNA regulatory element RL Proc. Natl. Acad. Sci. USA 83:2817-2821 (1986). RN [8] RX MEDLINE; 85137874. RA von der Ahe D., Janich S., Scheidereit C., Renkawitz R., Schuetz G., Beato RA M. RT Glucocorticoid and progesterone receptors bind the same sites in two RT hormonally regulated promoters RL Nature 313:706-709 (1985). XX // AC G000065 XX ID CHICK$MGF XX DT 21.05.1996 (created); ake. DT 28.11.2000 (updated); rio. CO Copyright (C), Biobase GmbH. XX SD MGF XX DE myelomonocytic growth factor XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.5 XX BS -253 -241 R09588; CHICK$MGF_02; Binding factors: Gbx2 . BS -95 -84 R09587; CHICK$MGF_01; Binding factors: Gbx2 . XX DR EMBL: M85034; GGCMGFA. DR TRANSPATH: G000065. DR TRANSCOMPEL: C00111. DR TRANSCOMPEL: C00112. XX RN [1] RX MEDLINE; 98004222. RA Kowenz-Leutz E., Herr P., Niss K., Leutz A. RT The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine RT growth and monocyte differentiation RL Cell 91:185-195 (1997). XX // AC G000066 XX ID CHICK$MIM1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD mim-1 XX DE myeloid protein-1 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.3 XX BS -242 8 R02100; CHICK$MIM1_04; Binding factors: c-Ets-2 , BS c-Myb . BS -206 0 R01096; CHICK$MIM1_01; Binding factors: v-Myb , BS v-Myb/v-Ets . BS -184 0 R01097; CHICK$MIM1_02; Binding factors: v-Myb , BS v-Myb/v-Ets . BS -145 0 R01098; CHICK$MIM1_03; Binding factors: v-Myb , BS v-Myb/v-Ets . XX DR EMBL: M29448; GGMIM1. DR TRANSPATH: G000066. DR TRANSCOMPEL: C00172. DR TRRD: 00179. XX RN [1] RX MEDLINE; 92159035. RA Dudek H., Tantravahi R. V., Rao V. N., Reddy E. Sh., Reddy E. P. RT Myb and Ets proteins cooperate in transcriptional activation of the mim-1 RT promoter RL Proc. Natl. Acad. Sci. USA 89:1291-1295 (1992). RN [2] RX MEDLINE; 90090611. RA Ness S. A., Marknell A., Graf T. RT The v-myb oncogene product binds to and activates the promyelocyte-specific RT mim-1 gene RL Cell 59:1115-1125 (1989). XX // AC G000067 XX ID CHICK$MLCL23 XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MLC XX DE myosin light chain embryonic, L23 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.5 XX BS -110 -85 R02673; CHICK$MLCL23_01. XX DR EMBL: X14428; GDMYAL12. DR EMBL: M34989; GGMLCE1. XX RN [1] RX MEDLINE; 90258841. RA Uetsuki T., Nabeshima Y., Fujisawa-Sehara A., Nabeshima Y.-I. RT Regulation of the Chicken Embryonic Myosin Light-Chain (L23) Gene: RT Existence of a Common Regulatory Element Shared by Myosin Alkali RT Light-Chain Genes RL Mol. Cell. Biol. 10:2562-2569 (1990). XX // AC G000068 XX ID CHICK$MLC2 XX DT 14.06.1995 (created); dbo. DT 16.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD MLC-2 XX DE cardiac myosin light chain-2 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.5.2 XX DR TRRD: 00078. XX // AC G000069 XX ID CHICK$SMHC XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MHC XX DE myosin heavy chain, skeletal XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.5 XX BS -46 -41 R02779; CHICK$SMHC_01; Binding factors: SGF-3 . XX DR TRANSPATH: G000069. XX RN [1] RX MEDLINE; 90338022. RA Subramaniam A., Gulick J., Robbins J. RT Analysis of the upstream regulatory region of a chicken skeletal myosin RT heavy chain gene RL J. Biol. Chem. 265:13986-13994 (1990). XX // AC G000070 XX ID CHICK$MLC2A XX DT 14.06.1995 (created); dbo. DT 10.12.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD MLC-2A XX DE myosin light chain 2-A, cardiac XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.5.2 XX BS -309 -299 R03018; CHICK$MLC2A_04. BS -295 -289 R03019; CHICK$MLC2A_05. BS -278 -271 R03020; CHICK$MLC2A_06. BS -186 0 R04256; CHICK$MLC2A_07; Binding factors: ABF-2 . BS -90 -71 R04257; CHICK$MLC2A_08. BS -72 -59 R01165; CHICK$MLC2A_01; Binding factors: ABF-1 , ABF-2 BS . BS -55 -44 R01166; CHICK$MLC2A_02. BS -33 -13 R01167; CHICK$MLC2A_03; Binding factors: TFIID . XX DR EMBL: M63969; GGMLC2A. DR EMBL: M10990; GGMYL2A1. DR EMBL: J02587; GGMYL2AB. DR EMBL: J03397; GGMYLCC. DR TRANSPATH: G000070. XX RN [1] RX MEDLINE; 92186842. RA Qasba P., Lin E., Zhou M. D., Kumar A., Siddiqui M. A. Q. RT A single transcription factor binds to two divergent sequence elements with RT a common function in cardiac myosin light chain-2 promoter RL Mol. Cell. Biol. 12:1107-1116 (1992). RN [2] RX MEDLINE; 91141519. RA Shen R., Goswami S. K., Mascareno E., Kumar A., Siddiqui M. A. Q. RT Tissue-specific transcription of the cardiac myosin light-chain 2 gene is RT regulated by an upstream repressor element RL Mol. Cell. Biol. 11:1676-1685 (1991). RN [3] RX MEDLINE; 89343969. RA Braun T., Tannich E., Buschhausen-Denker G., Arnold H.-H. RT Promoter Upstream Elements of the Chicken Cardiac Myosin Light-Chain 2-A RT Gene Interact with trans-Acting Regulatory Factors for Muscle-Specific RT Transcription RL Mol. Cell. Biol. 9:2513-2525 (1989). XX // AC G000071 XX ID CHICK$OA XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Ov XX DE ovalbumin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.3.1 XX BS -1124 -1095 R01192; CHICK$OA_01; Binding factors: NF-1 (-like proteins) BS . BS -900 -732 R01618; CHICK$OA_05. BS -898 -874 R08890; CHICK$OA_16; Binding factors: HNF-3alpha , BS HNF-3gamma , HNF-3beta . BS -784 -765 R03200; CHICK$OA_11. BS -655 -617 R03567; CHICK$OA_13; Binding factors: ER-alpha . BS -518 -483 R03568; CHICK$OA_14; Binding factors: ER-alpha . BS -345 -320 R01853; CHICK$OA_06. BS -310 -274 R03569; CHICK$OA_15; Binding factors: ER-alpha . BS -290 -275 R01854; CHICK$OA_07. BS -268 -240 R01855; CHICK$OA_08. BS -241 -218 R01856; CHICK$OA_09. BS -165 -129 R03566; CHICK$OA_12; Binding factors: ER-alpha . BS -160 -140 R01857; CHICK$OA_10. BS -90 -66 R01193; CHICK$OA_02; Binding factors: ARP-1 , COUP BS , COUP-TF1 , PPAR-alpha , RXR-alpha . BS -83 -71 R01194; CHICK$OA_03; Binding factors: ER-alpha . BS -52 -41 R01195; CHICK$OA_04; Binding factors: c-Fos , c-Jun BS , ER-alpha . XX DR EMBL: M29020; GDOVAL5A. DR EMBL: V00437; GGOV03. DR EMBL: J00895; GGOVAL01. DR TRANSPATH: G000071. DR TRRD: 00049. XX RN [1] RX MEDLINE; 99049275. RA Dean D. M., Berger R. R., Sanders M. M. RT A winged-helix family member is involved in a steroid hormone-triggered RT regulatory circuit RL Endocrinology 139:4967-4975 (1998). RN [2] RX MEDLINE; 92154686. RA Kato S., Tora L., Yamauchi J., Masushige S., Bellard M., Chambon P. RT A far upstream estrogen response element of the ovalbumin gene contains RT several half-palindromic 5'-TGACC-3' motifs acting synergistically RL Cell 68:731-742 (1992). RN [3] RX MEDLINE; 92375197. RA Kliewer S. A., Umesono K., Noonan D. J., Heyman R. A., Evans R. M. RT Convergence of 9-cis retinoic acid and peroxisome proliferator signalling RT pathways through heterodimer formation of their receptors RL Nature 358:771-774 (1992). RN [4] RX MEDLINE; 92159066. RA Kliewer S. A., Umesono K., Heyman R. A., Mangelsdorf D. J., Dyck J. A., RA Evans R. M. RT Retinoid X receptor COUP-TF interactions modulate retinoic acid signaling RL Proc. Natl. Acad. Sci. USA 89:1448-1452 (1992). RN [5] RX MEDLINE; 91244826. RA Schweers L. A., Sanders M. M. RT A protein with a binding specificity similar to NF-kappaB binds to a RT steroid-dependent regulatory element in the ovalbumin gene RL J. Biol. Chem. 266:10490-10497 (1991). RN [6] RX MEDLINE; 91118002. RA Ladias J. A. A., Karathanasis S. K. RT Regulation of the apolipoprotein A1 gene by ARP-1, a novel member of the RT steroid receptor superfamily RL Science 251:561-565 (1991). RN [7] RX MEDLINE; 91084855. RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor involves the RT Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [8] RX MEDLINE; 90237065. RA Schweers L. A., Frank D. E., Weigel N. L., Sanders M. M. RT The steroid-dependent regulatoryent element in the ovalbumin gene does not RT function as a typical steroid response element RL J. Biol. Chem. 265:7590-7595 (1990). RN [9] RX MEDLINE; 89295600. RA Wang L.-H., Tsai S. Y., Cook R. G., Beattie W. G., Tsai M.-J., O'Malley B. RA W. RT COUP transcription factor is a member of the steroid receptor superfamily RL Nature 340:163-166 (1989). RN [10] RX MEDLINE; 89385993. RA Pastorcic M., Bagchi M. K., Tsai S. Y., Tsai M.-J., O'Malley B. W. RT Multiple protein binding sites within the ovalbumin gene 5'-flanking RT region: isolation and characterization of sequence-specific binding proteins RL Nucleic Acids Res. 17:6693-6711 (1989). RN [11] RX MEDLINE; 89091124. RA Tora L., Gaub M.-P., Mader S., Dierich A., Bellard M., Chambon P. RT Cell-specific activity of a GGTCA half-palindromic oestrogen-responsive RT element in the chicken ovalbumin gene promoter RL EMBO J. 7:3771-3778 (1988). RN [12] RX MEDLINE; 88228086. RA Bradshaw M. S., Tsai M.-J., O'Malley B. W. RT A Far Upstream Ovalbumin Enhancer Binds Nuclear Factor-1-like Factor RL J. Biol. Chem. 263:8485-8490 (1988). RN [13] RX MEDLINE; 88261283. RA Hwung Y.-P., Crowe D. T., Wang L.-H., Tsai S. Y., Tsai M.-J. RT The COUP Transcription Factor Binds to an Upstream Promoter Element of the RT Rat Insulin II Gene RL Mol. Cell. Biol. 8:2070-2077 (1988). RN [14] RX MEDLINE; 87301713. RA Tsai S. Y., Sagami I., Wang H., Tsai M.-J., O'Malley B. W. RT Interaction between a DNA-Binding Transcription Factor (COUP) and a Non-DNA RT Binding Factor (S300-II) RL Cell 50:701-709 (1987). RN [15] RX MEDLINE; 88142803. RA Bagchi M. K., Tsai S. Y., Tsai M.-J., O'Malley B. W. RT Purification and Characterization of Chicken Ovalbumin Gene Upstream RT Promoter Transcription Factor from Homologous Oviduct Cells RL Mol. Cell. Biol. 7:4151-4158 (1987). RN [16] RX MEDLINE; 87089783. RA Sagami I., Tsai S. Y., Wang H., Tsai M.-J., O'Malley B. W. RT Identification of Two Factors Required for Transcription of the Ovalbumin RT Gene RL Mol. Cell. Biol. 6:4259-4267 (1986). RN [17] RX MEDLINE; 87064584. RA Pastorcic M., Wang H., Elbrecht A., Tsai S. Y., Tsai M.-J., O'Malley B. W. RT Control of transcription initiation in vitro requires binding of a RT transcription factor to the distal promoter of the ovalbumin gene RL Mol. Cell. Biol. 6:2784-2791 (1986). RN [18] RX MEDLINE; 85229954. RA Elbrecht A., Tsai S. Y., Tsai M.-J., O'Malley B. W. RT Identification by exonuclease footprinting of a distal promoter-binding RT protein from HeLa cell extracts RL DNA 4:233-240 (1985). XX // AC G000072 XX ID CHICK$PR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD PR XX DE progesterone receptor XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.5.15 XX BS -998 -984 R02993; CHICK$PR_01; Binding factors: PR B , PR A BS . BS -917 -903 R02994; CHICK$PR_02; Binding factors: PR B , PR A BS . BS -899 -885 R02995; CHICK$PR_03; Binding factors: PR B , PR A BS . BS -251 -237 R02996; CHICK$PR_04; Binding factors: PR B , PR A BS . XX DR EMBL: M31104; GGPGRE1E. DR TRANSPATH: G000072. XX RN [1] RX MEDLINE; 91115888. RA Turcotte B., Meyer M.-E., Bellard M., Dretzen G., Gronemeyer H., Chambon P. RT Control of transcription of the chicken progesterone receptor gene RL J. Biol. Chem. 266:2582-2589 (1991). XX // AC G000073 XX ID CHICK$CMYC XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD c-myc XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.5.16 XX BS -232 -179 R04529; CHICK$CMYC_01; Binding factors: CTCF , CTCF BS . XX DR EMBL: J00889; GGMYC. DR TRANSPATH: G000073. DR SMARTDB: SM0000206. DR TRRD: 00175. XX RN [1] RX MEDLINE; 96220465. RA Filippova G. N., Fagerlie S., Klenova E. M., Meyers C., Dehner Y., Goodwin RA G., Neiman P. E., Collins S. J., Lobanenkov V. V. RT An exceptionally conserved transcriptional repressor, CTCF, employs RT different combinations of zinc fingers to bind diverged promoter sequences RT of avian and mammalian c-myc oncogenes RL Mol. Cell. Biol. 16:2802-2813 (1996). RN [2] RX MEDLINE; 94067122. RA Klenova E. M., Nicolas R. H., Paterson H. F., Carne A. F., Heath C. M., RA Goodwin G. H., Neiman P. E., Lobanenkov V. V. RT CTCF, a conserved nuclear factor required for optimal transcriptional RT activity of the chicken c-myc gene, is an 11-Zn-finger protein RT differentially expressed in multiple forms RL Mol. Cell. Biol. 13:7612-7624 (1993). XX // AC G000074 XX ID CHICK$L5 XX DT 21.05.1996 (created); ake. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD rp L5 XX DE ribosomal protein L5 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.3.2 XX DR TRRD: 00142. XX // AC G000075 XX ID CHICK$L7A XX DT 21.05.1996 (created); ake. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD rpL7a XX DE ribosomal protein L7a gene, Surf-3 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.3.2 XX DR TRRD: 00134. XX // AC G000076 XX ID CHICK$STN1 XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD sTnI XX DE skeletal troponin I XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.5.4 XX BS -14 1 R01620; CHICK$STN1_01; Binding factors: LBP-1 , MyoD BS . BS 3 20 R01621; CHICK$STN1_02; Binding factors: LBP-1 , NF-1 BS (-like proteins) . BS 23 38 R01622; CHICK$STN1_03; Binding factors: LBP-1 , NF-1 BS (-like proteins) . XX DR TRANSPATH: G000076. DR TRRD: 00393. XX RN [1] RA Faber P. W., van Rooij H. C. J., Schipper H. J., Brinkmann A. O., Trapman J. RT Two different overlapping pathways of transcription initiation are active RT on the TATA-less human androgen receptor promoter RL J. Biol. Chem. 268:9296-9301 (1993). RN [2] RX MEDLINE; 90287136. RA Nikovits jr W., Mar J. H., Ordahl C. P. RT Muscle-Specific Activity of the Skeletal Troponin I Promoter Requires RT Interaction between Upstream Regulatory Sequences and Elements Contained RT within the First Transcribed Exon RL Mol. Cell. Biol. 10:3468-3482 (1990). XX // AC G000077 XX ID CHICK$U1SN XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD U1 snRNA XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.1.1 XX BS -218 -208 R01493; CHICK$U1SN_01. BS -209 -180 R02596; CHICK$U1SN_02; Binding factors: SBF . XX DR EMBL: X01091; GGU152A. DR EMBL: X01093; GGU152C. DR TRANSPATH: G000077. DR TRRD: 00128. XX RN [1] RX MEDLINE; 90097845. RA Roebuck K. A., Szeto D. P., Green K. P., Fan Q. N., Stumph W. E. RT Octamer and SPH Motifs in the U1 Enhancer Cooperate To Activate U1 RNA Gene RT Expression RL Mol. Cell. Biol. 10:341-352 (1990). RN [2] RX MEDLINE; 88142807. RA Roebuck K. A., Walker R. J., Stumph W. E. RT Multiple Functional Motifs in the Chicken U1 RNA Gene Enhancer RL Mol. Cell. Biol. 7:4185-4193 (1987). XX // AC G000078 XX ID CHICK$U4RNA XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD U4snRNA XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.1.4 XX DR TRRD: 00178. XX // AC G000079 XX ID CHICK$U4BSN XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD U4B snRNA XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.1.4 XX BS -211 -189 R01507; CHICK$U4BSN_01; Binding factors: SBF . XX DR EMBL: M14136; GGU4BX. DR TRANSPATH: G000079. XX RN [1] RX MEDLINE; 91081320. RA Zamrod Z., Stumph W. E. RT U4B snRNA gene enhancer activity requires functional octamer and SPH motifs RL Nucleic Acids Res. 18:7323 (1990). RN [2] RX MEDLINE; 88067753. RA McNamara K. J., Walker R. J., Roebuck K. A., Stumph W. E. RT Transcriptional signals of a U4 small nuclear RNA gene RL Nucleic Acids Res. 15:9239-9254 (1987). XX // AC G000080 XX ID CHICK$VIMEN XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD VIM XX DE vimentin XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.2.6 XX BS -1604 -1587 R04269; CHICK$VIMEN_02. BS -608 -579 R01684; CHICK$VIMEN_01. XX DR EMBL: M15850; GGVIM1. DR EMBL: M81309; GGVIM5F. XX RN [1] RX MEDLINE; 92236598. RA Stover D. M., Zehner Z. E. RT Identification of a cis-acting DNA antisilencer element which modulates RT vimentin gene expression RL Mol. Cell. Biol. 12:2230-2240 (1992). RN [2] RX MEDLINE; 90220621. RA Farrell F. X., Sax C. M., Zehner Z. E. RT A Negative Element Involved in Vimentin Gene Expression RL Mol. Cell. Biol. 10:2349-2358 (1990). XX // AC G000081 XX ID CHICK$VIT2 XX DT 14.06.1995 (created); dbo. DT 14.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD VIT-II XX DE vitellogenin II XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; galliformes; phasianidae XX BC 6.1.3.2 XX BS -858 -803 R01568; CHICK$VIT2_01; Binding factors: ER-alpha , BS NF-1 (-like proteins) . BS -856 -824 R01569; CHICK$VIT2_02; Binding factors: NF-1 (-like proteins) BS . BS -848 -825 R01570; CHICK$VIT2_03; Binding factors: ER-alpha . BS -635 -614 R01571; CHICK$VIT2_04; Binding factors: ER-alpha . BS -625 -610 R01572; CHICK$VIT2_05; Binding factors: NHP-1 , NHP-1 BS , NHP-1 . BS -620 -597 R01573; CHICK$VIT2_06; Binding factors: ER-alpha . BS -610 -593 R01574; CHICK$VIT2_07; Binding factors: NHP-2 , NHP-2 BS , NHP-2 . BS -610 -585 R01575; CHICK$VIT2_08; Binding factors: PR B . BS -604 -585 R01576; CHICK$VIT2_09; Binding factors: GR . BS -362 -344 R01577; CHICK$VIT2_10; Binding factors: ER-alpha . BS -342 -325 R01578; CHICK$VIT2_11. BS -303 -280 R01579; CHICK$VIT2_12; Binding factors: ER-alpha . BS -174 -169 R01580; CHICK$VIT2_13. BS -124 -80 R03123; CHICK$VIT2_20; Binding factors: Sp1 . BS -123 -105 R01581; CHICK$VIT2_14; Binding factors: C/EBPalpha . BS -93 -82 R03497; CHICK$VIT2_21; Binding factors: VBP , Hlf BS . BS -90 -77 R01582; CHICK$VIT2_15; Binding factors: TF-Vbeta . BS -53 -36 R01583; CHICK$VIT2_16; Binding factors: USF . BS -33 -18 R01584; CHICK$VIT2_17. BS 3 34 R01585; CHICK$VIT2_18; Binding factors: NHP4 , NHP-1 BS , MDBP-2 . BS 454 466 R01905; CHICK$VIT2_19; Binding factors: NHP-1 . XX DR EMBL: X00345; GGVI01. DR EMBL: X00204; GGVITE. DR EMBL: J00916; GGVITII. DR EMBL: X13607; GGVITIIG. DR EMBL: X04593; GGVITUP. DR TRANSPATH: G000081. DR TRRD: 00124. XX RN [1] RX MEDLINE; 88033296. RA Jousset C., Carron C., Boureux A., Tran Quang C., Oury C., Dusanter-Fourt RA I., Charon M., Levin J., Bernard O., Ghysdael J. RT A domain of TEL conserved in a subset of ETS proteins defines a specific RT oligomerization interface essential to the mitogenic properties of the RT TEL-PDGFR beta oncoprotein. RL EMBO J. 16:69-82 (1997). RN [2] RX MEDLINE; 94344108. RA Hunger S. P., Brown R., Cleary M. L. RT DNA-binding and transcriptional regulatory properties of hepatic leukemia RT factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF RL Mol. Cell. Biol. 14:5986-5996 (1994). RN [3] RX MEDLINE; 92017760. RA Iyer S. V., Davis D. L., Seal S. N., Burch B. E. RT Chicken vitellogenin gene-binding protein, a leucine zipper transcription RT factor that binds to an important control element in the chicken RT vitellogenin II promoter, is related to rat DBP RL Mol. Cell. Biol. 11:4863-4875 (1991). RN [4] RX MEDLINE; 91203891. RA Seal S. N., Davis D. L., Burch J. B. E. RT Mutational studies reveal a complex set of positive and negative control RT elements within the chicken vitellogenin II promoter RL Mol. Cell. Biol. 11:2704-2717 (1991). RN [5] RX MEDLINE; 92051329. RA Jost J.-P., Saluz H.-P., Pawlak A. RT Estradiol down regulates the binding activity of an avian vitellogenin gene RT repressor (MDBP-2) and triggers a gradual demethylation of the mCpG pair of RT its DNA binding site RL Nucleic Acids Res. 19:5771-5775 (1991). RN [6] RX MEDLINE; 90067825. RA Hughes M. J., Jost J.-P. RT The ubiquitous nuclear protein, NHP1, binds with high affinity to different RT sequences of the chicken vitellogenin II gene RL Nucleic Acids Res. 17:8511-8520 (1989). RN [7] RX MEDLINE; 89202377. RA Saluz H. P., Jost J. P. RT A simple high-resolution procedure to study DNA methylation and in vivo RT DNA-protein interactions on a single-copy gene level in higher eukaryotes RL Proc. Natl. Acad. Sci. USA 86:2602-2606 (1989). RN [8] RX MEDLINE; 89039890. RA Bakker O., Philipsen J. N. J., Hennis B. C., Ab G. RT Estrogen-Inducible Binding of a Nuclear Factor to the Vitellogenin Upstream RT Region RL Mol. Cell. Biol. 8:4557-4560 (1988). RN [9] RX MEDLINE; 89218992. RA Cato A. C. B., Heitlinger E., Ponta H., Klein-Hitpass L., Ryffel G. U., RA Bailly A., Rauch C., Milgrom E. RT Estrogen and Progesterone Receptor-Binding Sites on the Chicken RT Vitellogenin II Gene: Synergism of Steroid Hormone Action RL Mol. Cell. Biol. 8:5323-5330 (1988). RN [10] RX MEDLINE; 89041558. RA Philipsen J. N. J., Hennis B. C., Ab G. RT In vivo footprinting of the estrogen-inducible vitellogenin II gene from RT chicken RL Nucleic Acids Res. 16:9663-9676 (1988). RN [11] RX MEDLINE; 88320505. RA Saluz H. P., Feavers I. M., Jiricny J., Jost J. P. RT Genomic sequencing and invivo footprinting of an expression-specific DNase RT I-hypersensitive site of avian vitellogenin II promoter reveal a RT demethylation of a mCpG and a change in specific interactions of proteins RT with DNA RL Proc. Natl. Acad. Sci. USA 85:6697-6700 (1988). RN [12] RX MEDLINE; 88041124. RA Feavers I. M., Jiricny J., Moncharmont B., Saluz H. P., Jost J. P. RT Interaction of two nonhistone proteins with the estradiol response element RT of the avian vitellogenin gene modulates the binding of estradiol-receptor RT complex RL Proc. Natl. Acad. Sci. USA 84:7453-7457 (1987). RN [13] RX MEDLINE; 87016908. RA Saluz H. P., Jiricny J., Jost J. P. RT Genomic sequencing reveals a positive correlation between the kinetics of RT strand-specific DNA demethylation of the overlapping RT estradiol/glucocorticoid-receptor binding sites and the rate of avian RT vitellogenin mRNA synthesis RL Proc. Natl. Acad. Sci. USA 83:7167-7171 (1986). RN [14] RX MEDLINE; 84119500. RA Jost J.-P., Seldram M., Geiser M. RT Preferential binding of estrogen-receptor complex to a region containing RT the estrogen-dependent hypomethylation site preceding the chicken RT vitellogenin II gene RL Proc. Natl. Acad. Sci. USA 81:429-433 (1984). XX // AC G000082 XX ID DAUCE$EXT XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD extensin XX OS carrot, Daucus carota OC eukaryota; viridiplantae; embryobionta; magnoliophyta; magnoliopsida; OC rosidae; apiales; apiaceae XX BC 1.1.2.4.1 XX BS -1800 0 R00420; DAUCE$EXT_01. XX RN [1] RA Holdsworth M. J., Laties G. G. RT Identification of a wound-induced inhibitor of a nuclear factor that binds RT the carrot extensin gene RL Planta 180:74-81 (1989). XX // AC G000083 XX ID DHBV$DHBV XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD DHBV XX DE duck hepatitis B virus XX OS DHBV, duck hepatitis B virus OC viridae; ds-DNA enveloped viruses; hepadnaviridae XX BS -40 -26 R05086; DHBV$DHBV_02; Binding factors: HNF-3alpha , BS HNF-3B , HNF-3 . BS 2159 2351 R03409; DHBV$DHBV_01; Binding factors: EF-C . XX DR EMBL: M60677; HBDCG. DR TRANSPATH: G000083. XX RN [1] RX MEDLINE; 97126086. RA Welsheimer T., Newbold J. E. RT A functional Hepatocyte Nuclear Factor 3 binding site is a critical RT component of the duck hepatits B virus major surface antigen promoter RL J. Virol. 70:8813-8820 (1996). RN [2] RX MEDLINE; 91251243. RA Crescenzo-Chaigne B., Pillot J., Lilienbaum A., Levrero M., Elfassi E. RT Identification of a strong enhancer element upstream from the pregenomic RT RNA start site of the duck hepatitis B virus genome RL J. Virol. 65:3882-3886 (1991). XX // AC G000084 XX ID DIDI$ALF XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD ALF XX DE alpha-L-fucosidase XX OS slime mould, Dictyostelium discoideum OC Eukaryota; Dictyosteliida; Dictyostelium. XX BS -344 -323 R04037; DIDI$ALF_01. XX DR EMBL: M30465; DDFUCA. DR BRENDA: 3.2.1.51. DR BRENDA: 3.2.1.127. DR BRENDA: 3.2.1.127. XX RN [1] RX MEDLINE; 91234611. RA May T., Blusch J., Sachse A., Nellen W. RT A cis-acting element responsible for early gene induction by extracellular RT cAMP in Dictyostelium discoideum RL Mech. Dev. 33:147-156 (1991). XX // AC G000085 XX ID DIDI$CP1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CP1 XX DE cysteine protease XX OS slime mould, Dictyostelium discoideum OC Eukaryota; Dictyosteliida; Dictyostelium. XX BS -210 -195 R00236; DIDI$CP1_01; Binding factors: GBF . XX DR TRANSPATH: G000085. XX RN [1] RX MEDLINE; 90249746. RA Hjorth A. L., Pears C., Williams J. G., Firtel R. A. RT A developmentally regulated trans-acting factor recognizes dissimilar RT G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes RL Genes Dev. 4:419-432 (1990). XX // AC G000086 XX ID DIDI$CP2 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CP2 XX DE pst-cathepsin XX OS slime mould, Dictyostelium discoideum OC Eukaryota; Dictyosteliida; Dictyostelium. XX BS -238 -210 R01288; DIDI$CP2_01; Binding factors: GBF . XX DR EMBL: M16039; DDPSTCAT. DR TRANSPATH: G000086. DR BRENDA: 2.8.2.1. XX RN [1] RX MEDLINE; 94170994. RA Schnitzler G. R., Fischer W. H., Firtel R. A. RT Cloning and characterization of the G-box binding factor, an essential RT component of the developmental switch between early and late development in RT Dictyostelium RL Genes Dev. 8:502-514 (1994). RN [2] RX MEDLINE; 90249746. RA Hjorth A. L., Pears C., Williams J. G., Firtel R. A. RT A developmentally regulated trans-acting factor recognizes dissimilar RT G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes RL Genes Dev. 4:419-432 (1990). RN [3] RX MEDLINE; 89306612. RA Hjorth A. L., Khanna N. C., Firtel R. A. RT A trans-acting factor required for cAMP-induced gene expression in RT Dictyostelium is regulated developmentally and induced by cAMP RL Genes Dev. 3:747-759 (1989). XX // AC G000087 XX ID DIDI$DG17 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD DG17 XX OS slime mould, Dictyostelium discoideum OC Eukaryota; Dictyosteliida; Dictyostelium. XX BS -257 -228 R00276; DIDI$DG17_01; Binding factors: GBF . BS -156 -138 R00277; DIDI$DG17_02; Binding factors: GBF . XX DR EMBL: M18106; DDDG17A. DR TRANSPATH: G000087. XX RN [1] RX MEDLINE; 90249746. RA Hjorth A. L., Pears C., Williams J. G., Firtel R. A. RT A developmentally regulated trans-acting factor recognizes dissimilar RT G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes RL Genes Dev. 4:419-432 (1990). XX // AC G000088 XX ID DIDI$UDPGPP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD UDPGPP XX DE UDP glucose pyrophosphorylase XX OS slime mould, Dictyostelium discoideum OC Eukaryota; Dictyosteliida; Dictyostelium. XX BS -386 -367 R01531; DIDI$UDPGPP_01; Binding factors: GBF . XX DR EMBL: M30467; DDUDPGP1. DR TRANSPATH: G000088. DR BRENDA: 2.7.7.9; Dictyostelium_discoideum. XX RN [1] RX MEDLINE; 90249746. RA Hjorth A. L., Pears C., Williams J. G., Firtel R. A. RT A developmentally regulated trans-acting factor recognizes dissimilar RT G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes RL Genes Dev. 4:419-432 (1990). XX // AC G000089 XX ID DROME$AC XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD ac XX DE achaete XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS -302 -293 R04159; DROME$AC_02; Binding factors: H , H . BS -71 -49 R03719; DROME$AC_01; Binding factors: AS-C T3 , Sc BS , Ac , Da . XX DR EMBL: M17120; DMACS1. DR TRANSPATH: G000089. XX RN [1] RX MEDLINE; 95047408. RA van Doren M., Bailey A. M., Esnayra J., Ede K., Posakony J. W. RT Negative regulation of proneural gene activity: hairy is a direct RT transcriptional repressor of achaete RL Genes Dev. 8:2729-2742 (1994). RN [2] RX MEDLINE; 92007741. RA Cabrera C. V., Alonso M. C. RT Transcriptional activation by heterodimers of the achaete-scute and RT daughterless gene products of Drosophila RL EMBO J. 10:2965-2973 (1991). XX // AC G000090 XX ID DROME$AC5C XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ACT 5C XX DE actin 5C XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.2.3.1 XX BS -332 -308 R02597; DROME$AC5C_03. BS -326 -319 R02467; DROME$AC5C_02. BS -38 -34 R00047; DROME$AC5C_01; Binding factors: B factor , TBP BS . XX DR EMBL: X06382; DM5CACT1. DR EMBL: M32055; DMACT504. DR EMBL: M20378; DMACTCA2. DR TRANSPATH: G000090. DR SMARTDB: SM0000180. DR SMARTDB: SM0000181. XX RN [1] RX MEDLINE; 91187842. RA Kaufman P. D., Rio D. C. RT Drosophila P-element transposase is a transcriptional repressor in vitro RL Proc. Natl. Acad. Sci. USA 88:2613-2317 (1991). RN [2] RX MEDLINE; 90097829. RA Chung Y.-T., Keller E. B. RT Regulatory Elements Mediating Transcription from the Drosophila RT melanogaster Actin 5C Proximal Promoter RL Mol. Cell. Biol. 10:206-216 (1990). RN [3] RX MEDLINE; 91061723. RA Chung Y.-T., Keller E. B. RT Positive and negative regulatory elements mediating transcription from the RT Drosophila melanogaster actin 5C distal promoter RL Mol. Cell. Biol. 10:6172-6180 (1990). RN [4] RX MEDLINE; 84106841. RA Parker C. S., Topol J. RT A Drosophila RNA polymerase II transcription factor contains a RT promoter-region-specific DNA-binding activity RL Cell 36:357-369 (1984). XX // AC G000091 XX ID DROME$ADH XX DT 14.06.1995 (created); dbo. DT 19.02.1999 (updated); ili. CO Copyright (C), Biobase GmbH. XX SD Adh XX DE alcohol dehydrogenase XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.4.3 XX BS -706 -680 R01969; DROME$ADH_25. BS -646 -624 R01972; DROME$ADH_26. BS -589 -564 R01973; DROME$ADH_27. BS -577 -552 R01952; DROME$ADH_17. BS -539 -516 R01955; DROME$ADH_18; Binding factors: DEP4 , AEF-1 BS . BS -516 -489 R01976; DROME$ADH_28. BS -492 -474 R01956; DROME$ADH_19; Binding factors: DEP2 . BS -485 -474 R04280; DROME$ADH_34; Binding factors: FTZ-F1 . BS -459 -450 R01977; DROME$ADH_29. BS -449 -437 R04281; DROME$ADH_35; Binding factors: DEP3 . BS -403 -386 R01978; DROME$ADH_30. BS -395 -360 R00053; DROME$ADH_01. BS -337 -330 R01959; DROME$ADH_20; Binding factors: DEP2 . BS -282 -257 R00054; DROME$ADH_02. BS -269 -229 R00064; DROME$ADH_12. BS -267 -217 R01981; DROME$ADH_31. BS -220 -187 R00055; DROME$ADH_03; Binding factors: Adf-2a . BS -212 -201 R01984; DROME$ADH_32. BS -205 -182 R01960; DROME$ADH_21. BS -167 -122 R00065; DROME$ADH_13. BS -162 -128 R01963; DROME$ADH_22. BS -151 -105 R00066; DROME$ADH_14; Binding factors: Adf-1 . BS -143 -98 R00056; DROME$ADH_04. BS -138 -103 R00067; DROME$ADH_15; Binding factors: Adf-1 . BS -125 -95 R01964; DROME$ADH_23. BS -120 -62 R00057; DROME$ADH_05. BS -98 -77 R00068; DROME$ADH_16. BS -97 -60 R01985; DROME$ADH_33. BS -86 -47 R00058; DROME$ADH_06; Binding factors: Adf-1 . BS -86 -77 R00059; DROME$ADH_07; Binding factors: Adf-1 . BS -68 -58 R00060; DROME$ADH_08; Binding factors: Adf-1 . BS -45 -21 R01968; DROME$ADH_24. BS -36 -22 R00061; DROME$ADH_09; Binding factors: TBP . BS -35 -5 R00062; DROME$ADH_10. BS -7 18 R00063; DROME$ADH_11; Binding factors: Adf-2b . XX DR EMBL: M17837; DMADHCK. DR EMBL: Z00030; DMADHGC. DR EMBL: X04454; DMADHN4. DR EMBL: X60793; DMNC16ADH. DR EMBL: X60792; DMRI32ADH. DR TRANSPATH: G000091. DR SMARTDB: SM0000125. DR SMARTDB: SM0000126. DR SMARTDB: SM0000127. DR SMARTDB: SM0000128. DR BRENDA: 1.1.1.1; Drosophila_melanogaster. XX RN [1] RX MEDLINE; 92115725. RA England B. P., Admon A., Tjian R. RT Cloning of Drosophila transcription factor Adf-1 reveals homology to Myb RT oncoproteins RL Proc. Natl. Acad. Sci. USA 89:683-687 (1992). RN [2] RX MEDLINE; 92123191. RA Ayer S., Benyajati C. RT The binding site of a steroid hormone receptor-like protein within the RT Drosophila Adh adult enhancer is required for high levels of RT tissue-specific alcohol dehydrogenase expression RL Mol. Cell. Biol. 12:661- 673 (1992). RN [3] RX MEDLINE; 92375078. RA Falb D., Maniatis T. RT Drosophila transcriptional repressor protein that binds specifically to RT negative control elements in fat body enhancers RL Mol. Cell. Biol. 12:4093-4103 (1992). RN [4] RX MEDLINE; 90202990. RA England B. P., Heberlein U., Tjian R. RT Purified Drosophila Transcription Factor, Adh Distal Factor-1 (Adf-1), RT Binds to Sites in Several Drosophila Promoters and Activates Transcription RL J. Biol. Chem. 265:5086-5094 (1990). RN [5] RX MEDLINE; 90136567. RA Moses K., Heberlein U., Ashburner M. RT The Adh gene promoters of Drosophila melanogaster and Drosophila orena are RT functionally conserved and share features of sequence structure and RT nuclease-protected sites RL Mol. Cell. Biol. 10:539-548 (1990). RN [6] RX MEDLINE; 90245566. RA Ewel A., Jackson J. R., Benyajati C. RT Alternative DNA-protein interactions in variable-length internucleosomal RT regions associated with Drosophila Adh distal promoter expression RL Nucleic Acids Res. 18:1771-1781 (1990). RN [7] RX MEDLINE; 88122611. RA Heberlein U., Tjian R. RT Temporal pattern of alcohol dehydrogenase gene transcription reproduced by RT Drosophila stage-specific embryonic extracts RL Nature 331:410-415 (1988). RN [8] RX MEDLINE; 88082682. RA Cartwright I. L. RT Developmental switch in chromatin structure associated with alternate RT promoter usage in the Drosophila melanogaster alcohol dehydrogenase gene RL EMBO J. 6:3097-3101 (1987). RN [9] RX MEDLINE; 85228247. RA Heberlein U., England B., Tjian R. RT Characterization of Drosophila transcription factors that activate the RT tandem promoters of the alcohol dehydrogenase gene RL Cell 41:965-977 (1985). XX // AC G000092 XX ID DROME$ANTP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Antp XX DE Antennapedia XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.5.3.2 XX BS empty empty R02510; DROME$ANTP_12; Binding factors: Ftz . BS -231 -218 R01871; DROME$ANTP_05. BS -222 -200 R00130; DROME$ANTP_02; Binding factors: Adf-1 . BS -192 -166 R00131; DROME$ANTP_03; Binding factors: Adf-1 . BS -185 -150 R01872; DROME$ANTP_06. BS -114 -59 R01873; DROME$ANTP_07; Binding factors: DTF-1 . BS -107 -67 R00132; DROME$ANTP_04; Binding factors: Adf-1 . BS -54 -27 R01874; DROME$ANTP_08; Binding factors: DTF-1 . BS -24 -1 R01875; DROME$ANTP_09. BS -24 -1 R01876; DROME$ANTP_10; Binding factors: AP-1 . BS -6 0 R00129; DROME$ANTP_01; Binding factors: Antp . BS 17 52 R01877; DROME$ANTP_11. XX FA T00026; Antp. XX DR EMBL: X03789; DMANTPE3. DR EMBL: M14497; DMANTPG1. DR EMBL: M14491; DMANTPG3. DR EMBL: M95824; DMSEQB. DR TRANSPATH: G000092. DR TRRD: 00011. XX RN [1] RX MEDLINE; 91260710. RA Florence B., Handrow R., Laughon A. RT DNA-binding specificity of th fushi tarazu homeodomain RL Mol. Cell. Biol. 11:3613-3623 (1991). RN [2] RX MEDLINE; 90202990. RA England B. P., Heberlein U., Tjian R. RT Purified Drosophila Transcription Factor, Adh Distal Factor-1 (Adf-1), RT Binds to Sites in Several Drosophila Promoters and Activates Transcription RL J. Biol. Chem. 265:5086-5094 (1990). RN [3] RX MEDLINE; 89107995. RA Perkins K. K., Dailey G. M., Tjian R. RT In vitro analysis of the Antennapedia P2 promoter: identification of a new RT Drosophila transcription factor RL Genes Dev. 2:1615-1626 (1988). RN [4] RX MEDLINE; 89043970. RA Mihara H., Kaiser E. T. RT A chemically synthesized Antennapedia homeo domain binds to a specific DNA RT sequence RL Science 242:925-927 (1988). XX // AC G000093 XX ID DROME$CF2 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CF2 XX DE chorion factor 2 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS -110 -90 R02316; DROME$CF2_01; Binding factors: CF2-I . XX DR EMBL: M97196; DMBPIS. DR TRANSPATH: G000093. XX RN [1] RX MEDLINE; 93030711. RA Hsu T., Gogos J. A., Kirsh S. A., Kafatos F. C. RT Multiple Zinc finger forms resulting from developmentally regulated RT alternative splicing of a transcription factor gene RL Science 257:1946-1950 (1992). XX // AC G000094 XX ID DROME$DDC XX DT 14.06.1995 (created); dbo. DT 26.02.2001 (updated); ili. CO Copyright (C), Biobase GmbH. XX SD Ddc XX DE dopa decarboxylase XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.4.4 XX BS -1490 -1474 R02623; DROME$DDC_03. BS -1402 -1382 R02624; DROME$DDC_04. BS -1350 -1327 R02625; DROME$DDC_05. BS -1317 -1299 R02626; DROME$DDC_06. BS -1046 -1032 R02627; DROME$DDC_07. BS -1020 -990 R02628; DROME$DDC_08. BS -903 -890 R02629; DROME$DDC_09. BS -846 -834 R02630; DROME$DDC_10. BS -93 -76 R00293; DROME$DDC_01; Binding factors: Adf-1 . BS -75 -60 R00294; DROME$DDC_02. XX DR EMBL: X04661; DMDDC. DR EMBL: X16802; DMDDCENH. DR TRANSPATH: G000094. DR BRENDA: 4.1.1.28; Drosophila_melanogaster. XX RN [1] RX MEDLINE; 90202990. RA England B. P., Heberlein U., Tjian R. RT Purified Drosophila Transcription Factor, Adh Distal Factor-1 (Adf-1), RT Binds to Sites in Several Drosophila Promoters and Activates Transcription RL J. Biol. Chem. 265:5086-5094 (1990). RN [2] RX MEDLINE; 90108664. RA Dynlacht B. D., Attardi L. D., Admon A., Freeman M., Tjian R. RT Functional analysis of NTF-1, a developmentally regulated Drosophila RT transcription factor that binds neuronal cis elements RL Genes Dev. 3:1677-1688 (1989). RN [3] RX MEDLINE; 89306605. RA Johnson W. A., McCormick C. A., Bray S. J., Hirsh J. RT A neuron-specific enhancer of the Drosophila dopa decarboxylase gene RL Genes Dev. 3:676-686 (1989). RN [4] RX MEDLINE; 88196079. RA Bray S. J., Johnson W. A., Hirsh J., Heberlein U., Tjian R. RT A cis-acting element and associated binding factor required for CNS RT expression of the Drosophila melanogaster dopa decarboxylase gene RL EMBO J. 7:177-188 (1988). XX // AC G000095 XX ID DROME$DFD XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Dfd XX DE Deformed XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.5.3.2 XX BS 41 50 R03025; DROME$DFD_01; Binding factors: Dfd . BS 147 154 R03026; DROME$DFD_02; Binding factors: Dfd . BS 174 187 R03027; DROME$DFD_03; Binding factors: Dfd . BS 338 350 R03028; DROME$DFD_04; Binding factors: Dfd . XX DR EMBL: U63017; DMU63017. DR TRANSPATH: G000095. XX RN [1] RX MEDLINE; 91138961. RA Regulski M., Dessain S., McGinnis N., McGinnis W. RT High-affinity binding sites for the deformed protein are required for the RT function of an autoregulatory enhancer of the Deformed gene RL Genes Dev. 5:278-286 (1991). XX // AC G000096 XX ID DROME$DPP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD dpp XX DE decapentaplegic XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS -131 0 R04953; DROME$DPP_02; Binding factors: Zeste . BS -93 0 R04954; DROME$DPP_03; Binding factors: Zeste . BS -71 0 R04955; DROME$DPP_04; Binding factors: Zeste . BS 987 1028 R02509; DROME$DPP_01; Binding factors: Ubx . XX DR EMBL: M30116; DMDPPC. DR EMBL: U63857; DMU63857. DR TRANSPATH: G000096. XX RN [1] RX MEDLINE; 91216112. RA Ekker S. C., Young K. E., von Kessler D. P., Beachy P. A. RT Optimal DNA sequence recognition by the Ultrabithorax homeodomain of RT Drosophila RL EMBO J. 10:1179-1186 (1991). RN [2] RX MEDLINE; 91007256. RA St Johnston R. D., Hoffmann F. M., Blackman R. K., Segal D., Grimaila R., RA Padgett R. W., Irick H. A., Gelbart W. M. RT Molecular organization of the decapentaplegic gene in Drosophila RT melanogaster RL Genes Dev. 4:1114-1127 (1990). RN [3] RX MEDLINE; 89091140. RA Benson M., Pirrotta V. RT The Drosophila zeste protein binds cooperatively to sites in many gene RT regulatory regions: implications for transvection and gene regulation RL EMBO J. 7:3907-3915 (1988). XX // AC G000097 XX ID DROME$E74 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD E74 XX DE early ecdysone-inducible puff XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS empty empty R02386; DROME$E74_09; Binding factors: c-Ets-1 68 , BS E74A , PU.1 , Fli-1 , PU.1 , Tel-2b BS , Tel-2a , Tel-2c , NERF-1a . BS empty empty R02387; DROME$E74_10; Binding factors: E74A . BS empty empty R02388; DROME$E74_11; Binding factors: E74A . BS -215 -190 R01862; DROME$E74_01; Binding factors: GAGA factor . BS -177 -162 R01863; DROME$E74_02; Binding factors: GAGA factor . BS -157 -142 R01864; DROME$E74_03; Binding factors: GAGA factor . BS -129 -112 R01865; DROME$E74_04; Binding factors: GAGA factor . BS -116 -99 R01868; DROME$E74_07; Binding factors: Zeste , Zeste BS . BS -106 -96 R01866; DROME$E74_05; Binding factors: GAGA factor . BS -65 -48 R01867; DROME$E74_06; Binding factors: GAGA factor . BS -63 -48 R01869; DROME$E74_08; Binding factors: Zeste , Zeste BS . XX DR TRANSPATH: G000097. XX RN [1] RX MEDLINE; 21153768. RA Gu X., Shin B. H., Akbarali Y., Weiss A., Boltax J., Oettgen P., Libermann RA T. A. RT Tel-2 is a novel transcriptional repressor related to the Ets factor RT Tel/ETV-6 RL J. Biol. Chem. 276:9421-9436 (2001). RN [2] RX MEDLINE; 96347578. RA Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T. A. RT Characterization of NERF, a novel transcription factor related to the Ets RT factor ELF-1 RL Mol. Cell. Biol. 16:5091-5106 (1996). RN [3] RX MEDLINE; 93275657. RA Zhang L., Lemarchandel V., Romeo P.-H., Ben-David Y., Greer P., Bernstein A. RT The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing`s sarcoma, RT encodes a transcriptional activator with DNA-binding specifities distinct RT from other Ets family members RL Oncogene 8:1621-1630 (1993). RN [4] RX MEDLINE; 91004225. RA Urness L. D., Thummel C. S. RT Molecular interactions within the ecdysone regulatory hierarchy: DNA RT binding properties of the Drosophila ecdysone-inducible E74A protein RL Cell 63:47-61 (1990). RN [5] RX MEDLINE; 89306615. RA Thummel C. S. RT The Drosophila E74 promoter contains essential sequences downstream from RT the start site of transcription RL Genes Dev. 3:782-792 (1989). XX // AC G000098 XX ID DROME$EN XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD en XX DE engrailed XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.5.3.1 XX BS empty empty R00414; DROME$EN_04; Binding factors: En , POU2F2 BS (Oct-2.1) . BS empty empty R02272; DROME$EN_08; Binding factors: Ttk 88K . BS -2370 0 R02505; DROME$EN_10; Binding factors: Antp . BS -2280 0 R02504; DROME$EN_09; Binding factors: Antp . BS -933 -923 R03022; DROME$EN_11; Binding factors: Hb . BS -926 -892 R00411; DROME$EN_01; Binding factors: En , Eve BS , Ftz , Prd , Zen-1 , Zen-2 . BS -882 -873 R03023; DROME$EN_12; Binding factors: Hb . BS -873 -852 R00412; DROME$EN_02; Binding factors: En , Eve BS , Ftz , Kr , Zen-1 , Zen-2 . BS -754 -729 R00413; DROME$EN_03; Binding factors: Eve , POU2F2 BS (Oct-2.1) , Zen-1 , Zen-2 . BS 765 783 R01781; DROME$EN_05; Binding factors: En . BS 845 854 R01782; DROME$EN_06; Binding factors: En . BS 874 886 R01783; DROME$EN_07; Binding factors: En . XX DR EMBL: M29285; DMENG. DR EMBL: X01765; DMHOB48A. DR TRANSPATH: G000098. XX RN [1] RX MEDLINE; 92191990. RA Read D., Manley J. L. RT Alternatively spliced transcripts of the Drosophila tramtrack gene encode RT zinc finger proteins with distinct DNA binding specificities RL EMBO J. 11:1035-1044 (1992). RN [2] RX MEDLINE; 91138959. RA Zuo P., Stanojevic D., Colgan J., Han K., Levine M., Manley J. L. RT Activation and repression of transcription by the gap proteins hunchback RT and Krueppel in cultured Drosophila cells RL Genes Dev. 5:254-264 (1991). RN [3] RX MEDLINE; 90272660. RA Affolter M., Percival-Smith A., Mueller M., Leupin W., Gehring W. J. RT DNA binding properties of the purified Antennapedia homeodomain RL Proc. Natl. Acad. Sci. USA 87:4093-4097 (1990). RN [4] RX MEDLINE; 90066437. RA Kassis J. A., Desplan C., Wright D. K., O'Farrell P. H. RT Evolutionary Conservation of Homeodomain-Binding Sites and Other Sequences RT Upstream and within the Major Transcription Unit of the Drosophila RT Segmentation Gene engrailed RL Mol. Cell. Biol. 9:4304-4311 (1989). RN [5] RX MEDLINE; 88327852. RA Desplan C., Theis J., O'Farrell P. H. RT The sequence specificity of homeodomain-DNA interaction RL Cell 54:1081-1090 (1988). RN [6] RX MEDLINE; 89003042. RA Ko H.-S., Fast P., McBride W., Staudt L. M. RT A Human Protein Specific for the Immunoglobulin Octamer DNA Motif Contains RT a Functional Homeobox Domain RL Cell 55:135-144 (1988). RN [7] RX MEDLINE; 89096828. RA Hoey T., Warrior R., Manak J., Levine M. RT DNA-Binding Activities of Drosophila melanogaster even-skipped Protein Are RT Mediated by Its Homeo Domain and Influenced by Protein Context RL Mol. Cell. Biol. 8:4598-4607 (1988). RN [8] RX MEDLINE; 88189355. RA Hoey T., Levine M. RT Divergent homeo box proteins recognize similar DNA sequences in Drosophila RL Nature 332:858-861 (1988). RN [9] RX MEDLINE; 89070675. RA Scheidereit C., Cromlish J. A., Gerster T., Kawakami K., Balmaceda C.-G., RA Currie R. A., Roeder R. G. RT A human lymphoid-specific transcription factor that activates RT immunoglobulin genes is a homeobox protein RL Nature 336:551-557 (1988). XX // AC G000099 XX ID DROME$EVE XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD eve XX DE even-skipped XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS empty empty R02809; DROME$EVE_33; Binding factors: Prd . BS -5325 0 R03029; DROME$EVE_34; Binding factors: Eve . BS -5305 0 R03030; DROME$EVE_35; Binding factors: DENF1 . BS -5290 0 R03031; DROME$EVE_36; Binding factors: Eve . BS -5240 0 R03032; DROME$EVE_37; Binding factors: DENF2 . BS -5220 0 R03033; DROME$EVE_38; Binding factors: DENF3 . BS -1597 -1588 R02486; DROME$EVE_15; Binding factors: Kr . BS -1463 -1455 R02487; DROME$EVE_16; Binding factors: Bcd . BS -1462 -1453 R02488; DROME$EVE_17; Binding factors: Kr . BS -1443 -1418 R02490; DROME$EVE_19; Binding factors: Gt . BS -1442 -1434 R02489; DROME$EVE_18; Binding factors: Bcd . BS -1380 -1336 R02491; DROME$EVE_20; Binding factors: Gt . BS -1292 -1284 R02492; DROME$EVE_21; Binding factors: Bcd . BS -1275 -1266 R02493; DROME$EVE_22; Binding factors: Kr . BS -1199 -1191 R02494; DROME$EVE_23; Binding factors: Bcd . BS -1112 -1090 R02495; DROME$EVE_24; Binding factors: Gt . BS -1106 -1097 R02496; DROME$EVE_25; Binding factors: Hb . BS -1091 -1081 R02497; DROME$EVE_26; Binding factors: Kr . BS -1091 -1081 R02498; DROME$EVE_27; Binding factors: Bcd . BS -1030 -1021 R02499; DROME$EVE_28; Binding factors: Kr . BS -1024 -1015 R02500; DROME$EVE_29; Binding factors: Hb . BS -987 -977 R02501; DROME$EVE_30; Binding factors: Kr . BS -941 -932 R02502; DROME$EVE_31; Binding factors: Hb . BS -390 -372 R02057; DROME$EVE_03; Binding factors: Ttk 69K . BS -344 -330 R02058; DROME$EVE_04; Binding factors: GAGA factor . BS -319 -291 R02059; DROME$EVE_05; Binding factors: GAGA factor . BS -275 -243 R02060; DROME$EVE_06; Binding factors: Ttk 69K . BS -220 -200 R02061; DROME$EVE_07; Binding factors: Ttk 69K . BS -194 -161 R00418; DROME$EVE_01; Binding factors: Eve , Zen-1 BS , Zen-2 . BS -183 -155 R02062; DROME$EVE_08; Binding factors: GAGA factor . BS -149 -135 R02063; DROME$EVE_09; Binding factors: GAGA factor . BS -142 -118 R02801; DROME$EVE_32; Binding factors: Eve , Ftz BS , Pax-1 , Pax-2a , Pax-3 , Prd , BS Zen-1 , Pax-2b , Pax-2 , Zen-2 , Pax-9 BS . BS -118 -94 R02064; DROME$EVE_10; Binding factors: GAGA factor . BS -74 -59 R02065; DROME$EVE_11; Binding factors: GAGA factor . BS -44 -31 R02066; DROME$EVE_12; Binding factors: GAGA factor . BS -9 5 R02067; DROME$EVE_13; Binding factors: GAGA factor . BS 36 60 R02068; DROME$EVE_14. XX DR EMBL: M14767; DMEVE. DR TRANSPATH: G000099. XX RN [1] RX MEDLINE; 95377555. RA Neubueser A., Koseki H., Balling R. RT Characterization and developmental expression of Pax9, a RT paired-box-containing gene related to Pax1 RL Dev. Biol. 170:701-716 (1995). RN [2] RX MEDLINE; 92159012. RA Dressler G. R., Douglass E. C. RT Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor RL Proc. Natl. Acad. Sci. USA 89:1179-1183 (1992). RN [3] RX MEDLINE; 91138960. RA Jiang J., Hoey T., Levine M. RT Autoregulation of a segmentation gene in Drosophila: combinatorial RT interaction of the even-skipped homeo box protein with a distal enhancer RT element RL Genes Dev. 5:265-277 (1991). RN [4] RX MEDLINE; 91216108. RA Goulding M. D., Chalepakis G., Deutsch U., Erselius J. R., Gruss P. RT Pax-3, a novel murine DNA binding protein expressed during early RT neurogenesis RL EMBO J. 10:1135-1147 (1991). RN [5] RX MEDLINE; 91224492. RA Small S., Kraut R., Hoey T., Warrior R., Levine M. RT Transcriptional regulation of a pair-rule stripe in Drosophila RL Genes Dev. 5:827-839 (1991). RN [6] RX MEDLINE; 91184615. RA Treisman J., Harris E., Desplan C. RT The paired box encodes a second DNA-binding domain in the Paired homeo RT domain protein RL Genes Dev. 5:594-604 (1991). RN [7] RX MEDLINE; 92073911. RA Stanojevic D., Small S., Levine M. RT Regulation of segmentation stripe by overlapping activators and repressors RT in the Drosophila embryo RL Science 254:1385-1387 (1991). RN [8] RX MEDLINE; 90318400. RA Read D., Nishigaki T., Manley J. L. RT The Drosophila Even-Skipped Promoter Is Transcribed in a Stage-Specific RT Manner In Vitro and Contains Multiple, Overlapping Factor-Binding Sites RL Mol. Cell. Biol. 10:4334-4344 (1990). RN [9] RX MEDLINE; 90030427. RA Treisman J., Goenczy P., Vashishta M., Harris E., Desplan C. RT A single amino acid can determine the DNA binding specificity of RT homeodomain proteins RL Cell 59:553-562 (1989). RN [10] RX MEDLINE; 89096828. RA Hoey T., Warrior R., Manak J., Levine M. RT DNA-Binding Activities of Drosophila melanogaster even-skipped Protein Are RT Mediated by Its Homeo Domain and Influenced by Protein Context RL Mol. Cell. Biol. 8:4598-4607 (1988). RN [11] RX MEDLINE; 88189355. RA Hoey T., Levine M. RT Divergent homeo box proteins recognize similar DNA sequences in Drosophila RL Nature 332:858-861 (1988). XX // AC G000100 XX ID DROME$FTZ XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ftz XX DE fushi tarazu XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.5.3.1 XX BS -1700 0 R00481; DROME$FTZ_01; Binding factors: Elf-1 . BS -1700 0 R00482; DROME$FTZ_02; Binding factors: Elf-1 . BS -1600 0 R00483; DROME$FTZ_03; Binding factors: Elf-1 . BS -1600 0 R00484; DROME$FTZ_04; Binding factors: Elf-1 . BS -467 0 R02503; DROME$FTZ_29; Binding factors: Cad . BS -404 -385 R02557; DROME$FTZ_30; Binding factors: Cad . BS -368 -329 R02558; DROME$FTZ_32; Binding factors: GAGA factor . BS -313 -299 R02559; DROME$FTZ_33. BS -293 -274 R02560; DROME$FTZ_34. BS -291 -276 R00485; DROME$FTZ_05; Binding factors: BmFTZ-F1 , BS FTZ-F1 . BS -263 -234 R02561; DROME$FTZ_35. BS -195 -159 R02562; DROME$FTZ_36. BS -149 -131 R02563; DROME$FTZ_37. BS 918 934 R02351; DROME$FTZ_08; Binding factors: Ftz . BS 964 984 R02352; DROME$FTZ_09; Binding factors: Ftz . BS 1145 1166 R02353; DROME$FTZ_10; Binding factors: Ftz . BS 1251 1270 R02354; DROME$FTZ_11; Binding factors: Ftz . BS 1280 1309 R02355; DROME$FTZ_12; Binding factors: Ftz . BS 1326 1381 R02356; DROME$FTZ_13; Binding factors: Ftz . BS 1611 1638 R02357; DROME$FTZ_14; Binding factors: Ftz . BS 1621 1645 R02286; DROME$FTZ_06; Binding factors: Ttk 69K . BS 1621 1639 R02287; DROME$FTZ_07; Binding factors: Ttk 69K . BS 1708 1725 R02358; DROME$FTZ_15; Binding factors: Ftz . BS 1742 1761 R02359; DROME$FTZ_16; Binding factors: Ftz . BS 1849 1865 R02360; DROME$FTZ_17; Binding factors: Ftz . BS 1906 1920 R02361; DROME$FTZ_18; Binding factors: Ftz . BS 1944 1955 R02362; DROME$FTZ_19; Binding factors: Ftz . BS 1996 2008 R02363; DROME$FTZ_20; Binding factors: Ftz . BS 2091 2106 R02364; DROME$FTZ_21; Binding factors: Ftz . BS 2148 2173 R02365; DROME$FTZ_22; Binding factors: Ftz . BS 2177 2195 R02366; DROME$FTZ_23; Binding factors: Ftz . BS 2198 2204 R02367; DROME$FTZ_24; Binding factors: Ftz . BS 2203 2214 R02506; DROME$FTZ_31; Binding factors: Antp . BS 2263 2277 R02368; DROME$FTZ_25; Binding factors: Ftz . BS 2401 2416 R02369; DROME$FTZ_26; Binding factors: Ftz . BS 2436 2451 R02370; DROME$FTZ_27; Binding factors: Ftz . BS 2552 2568 R02371; DROME$FTZ_28; Binding factors: Ftz . XX DR EMBL: X00854; DMFTZ1. DR EMBL: X13402; DMFTZUSE. DR TRANSPATH: G000100. DR SMARTDB: SM0000123. DR SMARTDB: SM0000130. XX RN [1] RX MEDLINE; 93078768. RA Ueda H., Sun G.-C., Murata T., Hirose S. RT A novel DNA-binding motif abuts the zinc-finger domain of insect nuclear RT hormone receptor FTZ-F1 and mouse embryonal long terminal repeat-binding RT protein RL Mol. Cell. Biol. 12:5667-5672 (1992). RN [2] RX MEDLINE; 91305117. RA Ueda H., Hirose S. RT Defining the sequence recognized with BmFTZ-F1, a sequence specific DNA RT binding factor in the silkworm, Bombyx mori, as revealed by direct RT sequencing of bound oligonucleotides and gel mobility shift competition RT analysis RL Nucleic Acids Res. 19:3689-3693 (1991). RN [3] RX MEDLINE; 91227912. RA Lavorgna G., Ueda H., Clos J., Wu C. RT FTZ-F1, a steroid hormone receptor-like protein implicated in the RT activation of fushi tarazu RL Science 252:848-851 (1991). RN [4] RX MEDLINE; 91224494. RA Topol J., Dearolf C. R., Prakash K., Parker C. S. RT Synthetic oligonucleotides recreate Drosophila fushi tarazu zebra-stripe RT expression RL Genes Dev. 5:855-867 (1991). RN [5] RX MEDLINE; 90107945. RA Harrison S. D., Travers A. A. RT The tramtrack gene encodes a Drosophila finger protein that interacts with RT the ftz transcriptional regulatory region and shows a novel embryonic RT expression pattern RL EMBO J. 9:207-216 (1990). RN [6] RX MEDLINE; 90299133. RA Ueda H., Sonoda S., Brown J. L., Scott M. P., Wu C. RT A sequence-specific DNA-binding protein that activates fushi tarazu RT segmentation gene expression RL Genes Dev. 4:624-635 (1990). RN [7] RX MEDLINE; 91007265. RA Pick L., Schier A., Affolter M., Schmidt-Glenewinkel Th., Gehring W. J. RT Analysis of the ftz upstream element: germ layer-specific enhancers are RT independently autoregulated RL Genes Dev. 4:1224-1239 (1990). RN [8] RX MEDLINE; 91081308. RA Ueda H., Hirose S. RT Identification and purification of a Bombyx mori homologue of FTZ-F1 RL Nucleic Acids Res. 18:7229 (1990). RN [9] RX MEDLINE; 90211193. RA Dearolf C. R., Topol J., Parker C. S. RT Transcriptional regulation of the Drosophila segmentation gene fushi tarazu RT (ftz) RL BioEssays 12:109-113 (1990). RN [10] RX MEDLINE; 90272660. RA Affolter M., Percival-Smith A., Mueller M., Leupin W., Gehring W. J. RT DNA binding properties of the purified Antennapedia homeodomain RL Proc. Natl. Acad. Sci. USA 87:4093-4097 (1990). RN [11] RX MEDLINE; 90108664. RA Dynlacht B. D., Attardi L. D., Admon A., Freeman M., Tjian R. RT Functional analysis of NTF-1, a developmentally regulated Drosophila RT transcription factor that binds neuronal cis elements RL Genes Dev. 3:1677-1688 (1989). RN [12] RX MEDLINE; 90015119. RA Dearolf C. R., Topol J., Parker C. S. RT The caudal gene product is a direct activator of fushi tarazu transcription RT during Drosophila embryogenesis RL Nature 341:340 (1989). XX // AC G000101 XX ID DROME$GL XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD glass XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS -2518 -2503 R02291; DROME$GL_01; Binding factors: Glass . BS -2478 -2425 R02292; DROME$GL_02; Binding factors: Glass . XX DR TRANSPATH: G000101. XX RN [1] RX MEDLINE; 91184614. RA Moses K., Rubin G. M. RT glass encodes a site-specific DNA-binding protein that is regulated in RT response to positional signals in the developing Drosophila eye RL Genes Dev. 5:583-593 (1991). XX // AC G000102 XX ID DROME$GYP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD gypsy XX DE mdg4 retrotransposon XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS 410 0 R00626; DROME$GYP_02; Binding factors: su(f) . BS 726 764 R00625; DROME$GYP_01; Binding factors: su(Hw) . XX DR EMBL: M12927; DMGYPF1A. DR TRANSPATH: G000102. XX RN [1] RX MEDLINE; 94344073. RA Shen B., Kim J., Dorsett D. RT The enhancer-blocking suppressor of Hairy-wing zinc finger protein of RT Drosophila melanogaster alters DNA structure RL Mol. Cell. Biol. 14:5645-5652 (1994). RN [2] RX MEDLINE; 91071579. RA Spana C., Corces V. G. RT DNA bending is a determinant of binding specificity for a Drosophila zinc RT finger protein RL Genes Dev. 4:1505-1515 (1990). RN [3] RX MEDLINE; 89251622. RA Mazo A. M., Mizrokhi L. J., Karavanov A. A., Sedkov Y. A., Krichevskaja A. RA A., Ilyin Y. V. RT Suppression in Drosophila: su(Hw) and su(f) gene products interact with a RT region of gypsy (mdg4) regulating its transcriptional activity RL EMBO J. 8:903-911 (1989). XX // AC G000103 XX ID DROME$HB XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD hb XX DE hunchback XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS empty empty R02484; DROME$HB_01; Binding factors: Bcd , Prd BS . BS -2533 0 R02611; DROME$HB_04; Binding factors: Hb . BS -915 0 R02614; DROME$HB_07; Binding factors: Hb . BS -831 0 R02615; DROME$HB_08; Binding factors: Hb . BS -731 0 R02616; DROME$HB_09; Binding factors: Hb . BS -676 0 R02610; DROME$HB_03; Binding factors: Kr . BS -659 0 R02612; DROME$HB_05; Binding factors: Hb . BS -535 0 R02617; DROME$HB_10; Binding factors: Hb . BS -449 0 R02618; DROME$HB_11; Binding factors: Hb . BS -359 0 R02609; DROME$HB_02; Binding factors: Kr . BS -178 0 R02613; DROME$HB_06; Binding factors: Hb . BS 2812 2825 R03718; DROME$HB_12; Binding factors: AS-C T3 , Sc BS , Ac , Da . XX DR EMBL: Y00274; DMHBG. DR TRANSPATH: G000103. XX RN [1] RX MEDLINE; 92007741. RA Cabrera C. V., Alonso M. C. RT Transcriptional activation by heterodimers of the achaete-scute and RT daughterless gene products of Drosophila RL EMBO J. 10:2965-2973 (1991). RN [2] RX MEDLINE; 90030427. RA Treisman J., Goenczy P., Vashishta M., Harris E., Desplan C. RT A single amino acid can determine the DNA binding specificity of RT homeodomain proteins RL Cell 59:553-562 (1989). RN [3] RX MEDLINE; 90015117. RA Treisman J., Desplan C. RT The products of the Drosophila gap genes hunchback and Krueppel bind to the RT hunchback promoters RL Nature 341:335-337 (1989). XX // AC G000104 XX ID DROME$H3 XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H3 XX DE histone 3 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.2.1 XX BS -43 30 R00674; DROME$H3_01; Binding factors: B factor . BS -43 -41 R00675; DROME$H3_02. BS -43 -18 R00676; DROME$H3_03. BS -43 36 R00677; DROME$H3_04. XX DR EMBL: J01063; DM297H32. DR EMBL: K01488; DMHIS3P. DR EMBL: X14215; DMHISTL. DR TRANSPATH: G000104. DR SMARTDB: SM0000037. XX RN [1] RX MEDLINE; 89096908. RA Gilmour D. S., Dietz T. J., Elgin S. C. R. RT TATA Box-Dependent Protein-DNA Interactions Are Detected on Heat Shock and RT Histone Gene Promoters in Nuclear Extracts Derived from Drosophila RT melanogaster Embryos RL Mol. Cell. Biol. 8:3204-3214 (1988). RN [2] RX MEDLINE; 84106841. RA Parker C. S., Topol J. RT A Drosophila RNA polymerase II transcription factor contains a RT promoter-region-specific DNA-binding activity RL Cell 36:357-369 (1984). XX // AC G000105 XX ID DROME$HH4 XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H4 XX DE histone 4 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.2.1 XX BS -40 30 R00689; DROME$HH4_10; Binding factors: B factor . BS -40 -41 R00690; DROME$HH4_11. BS -40 -17 R00691; DROME$HH4_12. BS -40 37 R00692; DROME$HH4_13. XX DR TRANSPATH: G000105. DR SMARTDB: SM0000037. XX RN [1] RX MEDLINE; 89096908. RA Gilmour D. S., Dietz T. J., Elgin S. C. R. RT TATA Box-Dependent Protein-DNA Interactions Are Detected on Heat Shock and RT Histone Gene Promoters in Nuclear Extracts Derived from Drosophila RT melanogaster Embryos RL Mol. Cell. Biol. 8:3204-3214 (1988). RN [2] RX MEDLINE; 84106841. RA Parker C. S., Topol J. RT A Drosophila RNA polymerase II transcription factor contains a RT promoter-region-specific DNA-binding activity RL Cell 36:357-369 (1984). XX // AC G000106 XX ID DROME$HSP23 XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD hsp23 XX DE heat shock protein 23 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.6.2 XX BS -210 -180 R03319; DROME$HSP23_01; Binding factors: EcR . XX DR EMBL: X03889; DMHSP23G. DR TRANSPATH: G000106. XX RN [1] RX MEDLINE; 91260715. RA Luo Y., Amin J., Voellmy R. RT Ecdysterone receptor is a sequence-specific transcription factor involved RT in the developmental regulation of heat shock genes RL Mol. Cell. Biol. 11:3660-3675 (1991). XX // AC G000107 XX ID DROME$HSP26 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD hsp26 XX DE heat shock protein 26 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.6.2 XX BS -41 0 R00747; DROME$HSP26_01. BS -21 0 R00748; DROME$HSP26_02. BS 35 0 R00749; DROME$HSP26_03. XX RN [1] RX MEDLINE; 89096908. RA Gilmour D. S., Dietz T. J., Elgin S. C. R. RT TATA Box-Dependent Protein-DNA Interactions Are Detected on Heat Shock and RT Histone Gene Promoters in Nuclear Extracts Derived from Drosophila RT melanogaster Embryos RL Mol. Cell. Biol. 8:3204-3214 (1988). XX // AC G000108 XX ID DROME$HSP27 XX DT 14.06.1995 (created); dbo. DT 16.05.2001 (updated); mas. CO Copyright (C), Biobase GmbH. XX SD hsp27 XX DE heat shock protein 27 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.6.2 XX BS empty empty R09990; DROME$HSP27_05; Binding factors: RXR-alpha , BS FXR . BS -554 -455 R00750; DROME$HSP27_04; Binding factors: EcR . XX DR EMBL: Y07758; DMHSP27. DR EMBL: M12934; DMHSP27A. DR TRANSPATH: G000108. XX RN [1] RX MEDLINE; 95292336. RA Forman B. M., Goode E., Chen J., Oro A. E., Bradley D. J., Perlmann T., RA Noonan D. J., Burka L. T., McMorris T., Lamph W. W., et a. l. RT Identification of a nuclear receptor that is activated by farnesol RT metabolites RL Cell 81:687-693 (1995). RN [2] RX MEDLINE; 92005697. RA Koelle M. R., Talbot W. S., Segrawes W. A., Bender M. T., Cherbas P., RA Hogness D. S. RT The Drosophila EcR gene encodes an ecdysone receptor, a new member of the RT steroid receptor superfamily RL Cell 66:59-77 (1991). RN [3] RX MEDLINE; 91260715. RA Luo Y., Amin J., Voellmy R. RT Ecdysterone receptor is a sequence-specific transcription factor involved RT in the developmental regulation of heat shock genes RL Mol. Cell. Biol. 11:3660-3675 (1991). RN [4] RA Riddihough G., Pelham H. R. B. RT An ecdysone response element in the Drosophila hsp70 promoter RL EMBO J. 6:3729-3734 (1987). XX // AC G000109 XX ID DROME$HSP70 XX DT 14.06.1995 (created); dbo. DT 28.02.2002 (updated); ili. CO Copyright (C), Biobase GmbH. XX SD hsp70 XX DE heat shock protein 70 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.6.2 XX BS empty empty R09844; DROME$HSP70_10; Binding factors: BEAF-32A , BS BEAF-32B . BS empty empty R09849; DROME$HSP70_11; Binding factors: BEAF-32A , BS BEAF-32B . BS -258 -228 R00751; DROME$HSP70_01; Binding factors: HSF1 , HSTF BS . BS -189 -165 R00752; DROME$HSP70_02; Binding factors: HSTF . BS -108 -40 R00753; DROME$HSP70_03; Binding factors: HSTF . BS -99 -37 R00754; DROME$HSP70_04; Binding factors: HSF1 , HSTF BS , HSF1 (long) , HSF1 (short) . BS -92 -66 R00755; DROME$HSP70_05; Binding factors: HSTF . BS -62 -37 R00756; DROME$HSP70_06; Binding factors: HSF , HSF1 BS , HSTF . BS -40 -12 R00757; DROME$HSP70_07; Binding factors: En , TAB BS . BS -37 35 R00759; DROME$HSP70_09; Binding factors: B factor , BS TFIID . BS -21 0 R00758; DROME$HSP70_08. XX DR EMBL: V00213; DMHSP1. DR EMBL: V00219; DMHSP7. DR EMBL: J01103; DMHSP7A2. DR EMBL: M11072; DMHSP7BR. DR EMBL: X63732; DMRSIG2. DR TRANSPATH: G000109. DR SMARTDB: SM0000131. DR TRRD: 00033. XX RN [1] RX MEDLINE; 97154535. RA Hart CM Zhao K Laemmli UK. RT The scs' boundary element: characterization of boundary element-associated RT factors RL Mol. Cell. Biol. 17:999-1009 (1997). RN [2] RX MEDLINE; 95300220. RA Zhao K., Hart C. M., Laemmli U. K. RT Visualization of chromosomal domains with boundary element-associated RT factor BEAF-32 RL Cell 81:879-889 (1995). RN [3] RX MEDLINE; 94167242. RA Fernandes M., Xiao H., Lis J. T. RT Fine structure analyses of the Drosophila and Saccharomyces heat shock RT factor-heat shock element interactions RL Nucleic Acids Res. 22:167-173 (1994). RN [4] RX MEDLINE; 91121515. RA Xiao H., Perisic O., Lis J. T. RT Cooperative binding of Drosophila heat shock factor to arrays of a RT conserved 5 bp unit RL Cell 64:585-593 (1991). RN [5] RX MEDLINE; 92078307. RA Liu A. Y.-C., Choi H.-S., Lee Y.-K., Chen K. Y. RT Molecular events involved in transcriptional activation of heat shock genes RT become progessively refractory to heat stimulation during aging of human RT diploid fibroblasts RL J. Cell. Physiology 149:560-566 (1991). RN [6] RX MEDLINE; 91334376. RA Rabindran S. K., Giorgi G., Clos J., Wu C. RT Molecular cloning and expression of a human heat shock factor, HSF1 RL Proc. Natl. Acad. Sci. USA 88:6906-6910 (1991). RN [7] RX MEDLINE; 91009272. RA Choi H.-S., Lin Z., Li B., Liu A. Y.-C. RT Age-dependent decrease in the heat-inducible DNA sequence-specific binding RT activity in human diploid fibroblasts RL J. Biol. Chem. 265:18005-18011 (1990). RN [8] RX MEDLINE; 90318389. RA Gilmour D. S., Diez Th. J., Elgin S. C. R. RT UV Cross-Linking Identifies Four Polypeptides That Require the TATA Box To RT Bind to the Drosophila hsp70 Promoter RL Mol. Cell. Biol. 10:4233-4238 (1990). RN [9] RX MEDLINE; 90192793. RA Ohkuma Y., Horikoshi M., Roeder R. G., Desplan C. RT Engrailed, a homeodomain protein, can repress in vitro transcription by RT competition with the TATA box-binding protein transcription factor IID RL Proc. Natl. Acad. Sci. USA 87:2289-2293 (1990). RN [10] RX MEDLINE; 90075224. RA Perisic O., Xiao H., Lis J. T. RT Stable Binding of Drosophila Heat Shock Factor to Head-to-Head and RT Tail-to-Tail Repeats of a Conserved 5 bp Recognition Unit RL Cell 59:797-806 (1989). RN [11] RX MEDLINE; 88311087. RA Wiederrecht G., Seto D., Parker C. RT Isolation of the Gene Encoding the S. cerevisiae Heat Shock Transcription RT Factor RL Cell 54:841-853 (1988). RN [12] RX MEDLINE; 89066805. RA Goldenberg C. J., Luo Y., Fenna M., Baler R., Weinmann R., Voellmy R. RT Purified Human Factor Activates Heat Shock Promoter in a HeLa Cell-free RT Transcription System RL J. Biol. Chem. 263:19734-19739 (1988). RN [13] RX MEDLINE; 89096908. RA Gilmour D. S., Dietz T. J., Elgin S. C. R. RT TATA Box-Dependent Protein-DNA Interactions Are Detected on Heat Shock and RT Histone Gene Promoters in Nuclear Extracts Derived from Drosophila RT melanogaster Embryos RL Mol. Cell. Biol. 8:3204-3214 (1988). RN [14] RX MEDLINE; 87102899. RA Wiederrecht G., Shuey D. J., Kibbe W. A., Parker C. S. RT The Saccharomyces and Drosophila heat shock transcription factors are RT identical in size and DNA binding properties RL Cell 48:507-515 (1987). RN [15] RX MEDLINE; 86224095. RA Shuey D. J., Parker C. S. RT Binding of Drosophila Heat-Shock Gene Transcription Factor to the hsp 70 RT Promoter RL J. Biol. Chem. 261:7934-7940 (1986). RN [16] RX MEDLINE; 85282610. RA Topol J., Ruden D. M., Parker C. S. RT Sequences required for in vitro transcriptional activation of a Drosophila RT hsp 70 gene RL Cell 42:527-537 (1985). RN [17] RX MEDLINE; 84205650. RA Parker C. S., Topol J. RT A Drosophila RNA polymerase II transcription factor binds to the regulatory RT site of an hsp 70 gene RL Cell 37:273-283 (1984). RN [18] RX MEDLINE; 84191545. RA Wu C. RT Two protein-binding sites in chromatin implicated in the activation of RT heat-shock genes RL Nature 309:229-234 (1984). XX // AC G000110 XX ID DROME$HSP83 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD hsp83 XX DE heat shock protein 83 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.6.2 XX BS -86 -50 R00773; DROME$HSP83_01; Binding factors: HSF , HSTF BS . BS -39 -17 R00774; DROME$HSP83_02; Binding factors: TAB . XX DR EMBL: X00065; DMHS83. DR EMBL: X03811; DSHSP82. DR TRANSPATH: G000110. XX RN [1] RX MEDLINE; 90136591. RA Zimarino V., Tsai Ch., Wu C. RT Complex Modes of Heat Shock Factor Action RL Mol. Cell. Biol. 10:752-759 (1990). RN [2] RX MEDLINE; 84191545. RA Wu C. RT Two protein-binding sites in chromatin implicated in the activation of RT heat-shock genes RL Nature 309:229-234 (1984). RN [3] RX MEDLINE; 84295618. RA Wu C. RT Activating protein factor binds in vitro to upstream control sequences in RT heat shock gene chromatin RL Nature 311:81-84 (1984). XX // AC G000111 XX ID DROME$KNI XX DT 14.06.1995 (created); dbo. DT 16.02.1998 (updated); reader. CO Copyright (C), Biobase GmbH. XX SD kni XX DE knirps XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS -1551 -1543 R04959; DROME$KNI_03; Binding factors: Tll . BS -1527 -1519 R04960; DROME$KNI_04; Binding factors: Tll . BS -1425 -1417 R04961; DROME$KNI_05; Binding factors: Tll . BS -1423 -1411 R04962; DROME$KNI_06; Binding factors: Tll . BS -1379 -1355 R02620; DROME$KNI_02; Binding factors: Kr . BS -1346 -1321 R02619; DROME$KNI_01; Binding factors: Kr . XX DR EMBL: X13331; DMKNIRPS. DR TRANSPATH: G000111. XX RN [1] RX MEDLINE; 92188162. RA Pankratz M. J., Busch M., Hoch M., Seifert E., Joeckle H. RT Spatial control of the gap gene knirps in the Drosophila embryo by RT posterior morphogen system RL Science 255:986-989 (1992). RN [2] RX MEDLINE; 90015118. RA Pankratz M. J., Hoch M., Seifert E., Jaeckle H. RT Krueppel requirement for knirps enhancement reflects overlapping gap gene RT activities in the Drosophila embryo RL Nature 341:337-340 (1989). XX // AC G000112 XX ID DROME$KR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Kr XX DE Krueppel XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.5.3.1 XX BS -109 -95 R02266; DROME$KR_01; Binding factors: GAGA factor . BS -59 -48 R02267; DROME$KR_02; Binding factors: GAGA factor . BS -42 -30 R02268; DROME$KR_03; Binding factors: GAGA factor . BS 60 73 R02269; DROME$KR_04; Binding factors: GAGA factor . BS 90 105 R02270; DROME$KR_05; Binding factors: GAGA factor . BS 111 126 R02274; DROME$KR_07; Binding factors: Tll . BS 140 193 R03262; DROME$KR_19; Binding factors: Hb . BS 143 154 R02271; DROME$KR_06; Binding factors: GAGA factor . BS 214 233 R03263; DROME$KR_20; Binding factors: Hb . BS 235 256 R02275; DROME$KR_08; Binding factors: Bcd . BS 246 255 R02276; DROME$KR_09; Binding factors: Tll . BS 257 271 R03264; DROME$KR_21; Binding factors: Hb . BS 264 271 R02277; DROME$KR_10; Binding factors: Tll . BS 264 297 R02278; DROME$KR_11; Binding factors: Bcd . BS 315 324 R02279; DROME$KR_12; Binding factors: Tll . BS 323 366 R02280; DROME$KR_13; Binding factors: Bcd . BS 347 358 R02281; DROME$KR_14; Binding factors: Tll . BS 377 388 R03265; DROME$KR_22; Binding factors: Hb . BS 401 417 R03266; DROME$KR_23; Binding factors: Hb . BS 599 617 R02282; DROME$KR_15; Binding factors: Tll , TLX BS . BS 623 671 R03267; DROME$KR_24; Binding factors: Hb . BS 673 688 R02283; DROME$KR_16; Binding factors: KNIRPS . BS 677 701 R02284; DROME$KR_17; Binding factors: Bcd . BS 694 702 R02285; DROME$KR_18; Binding factors: Tll . XX DR EMBL: X13402; DMFTZUSE. DR EMBL: X03414; DMKR. DR TRANSPATH: G000112. XX RN [1] RX MEDLINE; 92229429. RA Hoch M., Gerwin N., Taubert H., Jaeckle H. RT Competition for overlapping sites in the regulatory region of the RT Drosophila gene Krueppel RL Science 256:94-97 (1992). RN [2] RX MEDLINE; 91293103. RA Hoch M., Seifert E., Jaeckle H. RT Gene expression mediated by cis-acting sequences of the Krueppel gene in RT response to the Drosophila morphogens bicoid and hunchback RL EMBO J. 10:2267-2278 (1991). RN [3] RX MEDLINE; 91093184. RA Kerrigan L. A., Croston G. E., Lira L. M., Kadonaga J. T. RT Sequence-specific transcriptional antirepression of the Drosophila Krueppel RT gene by the GAGA factor RL J. Biol. Chem. 266:574-582 (1991). XX // AC G000113 XX ID DROME$MDG1 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD MDG1 XX DE retrotransposon MDG1 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS -8 34 R03108; DROME$MDG1_01. XX DR EMBL: X59545; DMRTMGD1. XX RN [1] RX MEDLINE; 91216111. RA Arkhipova I. R., Ilyin Y. V. RT Properties of promoter regions of mdg1 Drosophila retrotransposon indicate RT that it belongs to a specific class of promoters RL EMBO J. 10:1169-1177 (1991). XX // AC G000114 XX ID DROME$PEL XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD P-element XX DE P transposable element XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS 44 70 R03080; DROME$PEL_01; Binding factors: TBP . BS 49 68 R03081; DROME$PEL_02. XX DR EMBL: X01803; ATPG418. DR TRANSPATH: G000114. XX RN [1] RX MEDLINE; 91187842. RA Kaufman P. D., Rio D. C. RT Drosophila P-element transposase is a transcriptional repressor in vitro RL Proc. Natl. Acad. Sci. USA 88:2613-2317 (1991). XX // AC G000115 XX ID DROME$PCNA XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD PCNA XX DE proliferating cell nuclear antigen XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS -337 -310 R01281; DROME$PCNA_01; Binding factors: Eve . BS -333 -310 R01282; DROME$PCNA_02; Binding factors: Zen-1 , Zen-2 BS . BS -287 -271 R01283; DROME$PCNA_03; Binding factors: Eve , Zen-1 BS , Zen-2 . BS -212 -168 R01284; DROME$PCNA_04; Binding factors: Eve , Zen-1 BS , Zen-2 . XX DR EMBL: M33950; DMPCNA. DR TRANSPATH: G000115. XX RN [1] RX MEDLINE; 90158601. RA Yamaguchi M., Nishida Y., Moriuchi T., Hirose F., Hui C.-C., Suzuki Y., RA Matsugake A. RT Drosophila proliferating cell nuclear antigen (cyclin) gene: structure, RT expression during development, and specific binding of homeodomain proteins RT to its 5'-flanking region RL Mol. Cell. Biol. 10:872-879 (1990). XX // AC G000116 XX ID DROME$RH1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Rh1 XX DE ninaE, opsin Rh1 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.5.4 XX BS -361 -311 R02289; DROME$RH1_02; Binding factors: Glass . BS -298 -283 R02290; DROME$RH1_03; Binding factors: Glass . BS -219 -194 R02288; DROME$RH1_01; Binding factors: Glass . XX DR EMBL: Y00601; DMNINAEP. DR TRANSPATH: G000116. XX RN [1] RX MEDLINE; 91184614. RA Moses K., Rubin G. M. RT glass encodes a site-specific DNA-binding protein that is regulated in RT response to positional signals in the developing Drosophila eye RL Genes Dev. 5:583-593 (1991). XX // AC G000117 XX ID DROME$S15 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD s15 XX DE chorion protein s15 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.2.7 XX BS -73 -55 R02293; DROME$S15_01; Binding factors: CF2-II . BS -71 -50 R02294; DROME$S15_02; Binding factors: CF1 . BS -41 -18 R02295; DROME$S15_03; Binding factors: CF2-II . XX DR EMBL: X02497; DMCHORSG. DR EMBL: X06257; DMS18S15. DR TRANSPATH: G000117. XX RN [1] RX MEDLINE; 93030712. RA Gogos J. A., Hsu T., Bolton J., Kafatos F. C. RT Sequence discrimination by alternatively spliced isoforms of a DNA binding RT Zinc finger domain RL Science 257:1951-1954 (1992). RN [2] RX MEDLINE; 93030711. RA Hsu T., Gogos J. A., Kirsh S. A., Kafatos F. C. RT Multiple Zinc finger forms resulting from developmentally regulated RT alternative splicing of a transcription factor gene RL Science 257:1946-1950 (1992). RN [3] RX MEDLINE; 93087556. RA Christianson A. M. K., King D. L., Hatzivassiliou E., Casas J. E., RA Hallenbeck P. L., Nikodem V. M., Mitsialis S. A., Kafatos F. C. RT DNA binding and heteromerization of the Drosophila transcription factor RT chorion factor 1/ultraspiracle RL Proc. Natl. Acad. Sci. USA 89:11503-11507 (1992). RN [4] RX MEDLINE; 91007257. RA Shea M. J., King D. L., Conboy M. J., Mariani B. D., Kafatos F. C. RT Proteins that bind to Drosophila chorion cis-regulatory elements: A new RT C2H2 zinc finger protein and a C2C2 steroid receptor-like component RL Genes Dev. 4:1128-1140 (1990). XX // AC G000118 XX ID DROME$SEVL XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD SEVL XX DE sevenless XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS 286 313 R03454; DROME$SEVL_01. BS 369 404 R03455; DROME$SEVL_02. BS 576 605 R03456; DROME$SEVL_03. BS 618 633 R03457; DROME$SEVL_04. BS 648 667 R03458; DROME$SEVL_05. BS 701 715 R03459; DROME$SEVL_06. XX DR EMBL: J03158; DMSEV. XX RN [1] RX MEDLINE; 91319782. RA Bowtell D. D. L., Lila T., Michael W. M., Hackett D., Rubin G. M. RT Analysis of the enhancer element that controls expression of sevenless in RT the developing Drosophila eye RL Proc. Natl. Acad. Sci. USA 88:6853-6857 (1991). XX // AC G000119 XX ID DROME$SGS3 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Sgs3 XX DE salivary gland secretion protein XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.2.5 XX BS -652 -592 R02901; DROME$SGS3_03; Binding factors: GEBF-I . BS -589 -568 R02902; DROME$SGS3_04; Binding factors: GEBF-I . BS -38 -31 R02663; DROME$SGS3_01. BS 1 9 R02664; DROME$SGS3_02. XX DR EMBL: X01918; DMSGS378. DR TRANSPATH: G000119. XX RN [1] RX MEDLINE; 91094868. RA Georgel Ph., Ramain Ph., Giangrande A., Dretzen G., Richards G., Bellard M. RT Sgs-3 chromatin structure and trans-activators: Developmental and ecdysone RT induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae RL Mol. Cell. Biol. 11:523-532 (1991). RN [2] RX MEDLINE; 90059941. RA Giangrande A., Mettling C., Martin M., Ruiz C., Richards G. RT Drosophila Sgs3 TATA: effects of point mutations on expression in vivo and RT protein binding in vitro with staged nuclear extracts RL EMBO J. 8:3459-3466 (1989). XX // AC G000120 XX ID DROME$SIM XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD sim XX DE single-minded XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS -2480 0 R04101; DROME$SIM_01; Binding factors: Sn . BS -2070 0 R04102; DROME$SIM_02; Binding factors: Sn . BS -525 -493 R04103; DROME$SIM_03; Binding factors: Sn . BS -373 -340 R04104; DROME$SIM_04; Binding factors: Sn . BS -279 -257 R04105; DROME$SIM_05; Binding factors: Sn . BS -250 -232 R04106; DROME$SIM_06; Binding factors: Sn . XX DR TRANSPATH: G000120. DR SMARTDB: SM0000182. DR SMARTDB: SM0000183. XX RN [1] RX MEDLINE; 92228796. RA Kasai Y., Nambu J. R., Lieberman P. M., Crews S. T. RT Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to RT the single-minded gene RL Proc. Natl. Acad. Sci. USA 89:3414-3418 (1992). XX // AC G000121 XX ID DROME$SRYBT XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD pBZ22a XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.7.2 XX BS empty empty R03390; DROME$SRYBT_01; Binding factors: Sry-beta . BS empty empty R03391; DROME$SRYBT_02; Binding factors: Sry-beta . BS empty empty R03392; DROME$SRYBT_03; Binding factors: Sry-beta . BS empty empty R03393; DROME$SRYBT_04; Binding factors: Sry-beta . BS empty empty R03399; DROME$SRYBT_05; Binding factors: Sry-beta . XX DR TRANSPATH: G000121. XX RN [1] RX MEDLINE; 91330876. RA Payre F., Vincent A. RT Genomic targets of the serendipity beta and delta zinc finger proteins and RT their respective DNA recognition sites RL EMBO J. 10:2533-2541 (1991). XX // AC G000122 XX ID DROME$SRYDT XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD pDZ112a XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.7.2 XX BS empty empty R03395; DROME$SRYDT_01; Binding factors: Sry-delta . BS empty empty R03396; DROME$SRYDT_02; Binding factors: Sry-delta . BS empty empty R03397; DROME$SRYDT_03; Binding factors: Sry-delta . BS empty empty R03398; DROME$SRYDT_04; Binding factors: Sry-delta . XX DR TRANSPATH: G000122. XX RN [1] RX MEDLINE; 91330876. RA Payre F., Vincent A. RT Genomic targets of the serendipity beta and delta zinc finger proteins and RT their respective DNA recognition sites RL EMBO J. 10:2533-2541 (1991). XX // AC G000123 XX ID DROME$TWI XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD twi XX DE twist XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS -1118 -1108 R01719; DROME$TWI_04; Binding factors: Dl . BS -1105 -1086 R01721; DROME$TWI_06; Binding factors: Dl . BS -1100 0 R03460; DROME$TWI_08; Binding factors: Dl . BS -1064 -1054 R01717; DROME$TWI_02; Binding factors: Dl . BS -820 0 R03461; DROME$TWI_09; Binding factors: Dl . BS -318 -309 R01722; DROME$TWI_07; Binding factors: Dl . BS -302 -292 R01718; DROME$TWI_03; Binding factors: Dl . BS -283 -270 R03462; DROME$TWI_10; Binding factors: Dl . BS -272 -262 R01720; DROME$TWI_05; Binding factors: Dl . BS -183 -173 R01716; DROME$TWI_01; Binding factors: Dl . XX DR EMBL: X12506; DMTWISTG. DR EMBL: S59100; S59100. DR TRANSPATH: G000123. XX RN [1] RX MEDLINE; 92258393. RA Pan D., Courey A. J. RT The same dorsal binding site mediates both activation and repression in a RT context-dependent manner RL EMBO J. 11:1837-1842 (1992). RN [2] RX MEDLINE; 91292522. RA Thisse C., Perrin-Schmitt F., Stoetzel C., Thisse B. RT Sequence-specific transactivation of the Drosophila twist gene by the RT dorsal gene product RL Cell 65:1191-1201 (1991). RN [3] RX MEDLINE; 92009178. RA Jiang J., Kosman D., Ip Y. T., Levine M. RT The dorsal morphogen gradient regulates the mesoderm determinant twist in RT early Drosophila embryos RL Genes Dev. 5:1881-1891 (1991). RN [4] RX MEDLINE; 92009179. RA Pan D., Huang J.-D., Courey A. J. RT Functional analysis of the Drosophila twist promoter reveals a RT dorsal-binding ventral activator region RL Genes Dev. 5:1892-1901 (1991). XX // AC G000124 XX ID DROME$UBX XX DT 14.06.1995 (created); dbo. DT 02.08.2001 (updated); dkl. CO Copyright (C), Biobase GmbH. XX SD Ubx XX DE ultrabithorax XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.5.3.2 XX BS empty empty R08636; DROME$UBX_24; Binding factors: LEF-1 . BS empty empty R10100; DROME$UBX_27; Binding factors: Shn , Mad BS , MEDEA (MED) . BS -453 -389 R10039; DROME$UBX_26. BS -419 -401 R10010; DROME$UBX_25; Binding factors: Mad . BS -205 -50 R01516; DROME$UBX_01; Binding factors: Zeste , Zeste BS . BS -193 -179 R01517; DROME$UBX_02; Binding factors: GAGA factor . BS -154 -31 R01518; DROME$UBX_03; Binding factors: Zeste , Zeste BS . BS -153 -138 R01519; DROME$UBX_04; Binding factors: Zeste , Zeste BS . BS -145 -128 R01520; DROME$UBX_05; Binding factors: GAGA factor . BS -132 -118 R01521; DROME$UBX_06; Binding factors: Zeste , Zeste BS . BS -120 -102 R01522; DROME$UBX_07; Binding factors: Elf-1 . BS -109 -95 R01523; DROME$UBX_08; Binding factors: Zeste , Zeste BS . BS -96 -81 R01524; DROME$UBX_09; Binding factors: GAGA factor . BS -79 -61 R01525; DROME$UBX_10; Binding factors: Zeste , Zeste BS . BS -52 -33 R01526; DROME$UBX_11; Binding factors: GAGA factor . BS -52 -38 R01527; DROME$UBX_12; Binding factors: Zeste , Zeste BS . BS 18 38 R01528; DROME$UBX_13; Binding factors: En . BS 30 0 R02554; DROME$UBX_17; Binding factors: Hb . BS 30 0 R02555; DROME$UBX_18; Binding factors: Hb . BS 30 0 R02556; DROME$UBX_19; Binding factors: Hb . BS 46 92 R01529; DROME$UBX_14; Binding factors: En , Eve BS , Ubx , Zen-1 , Zen-2 . BS 106 125 R01530; DROME$UBX_15. BS 175 357 R02622; DROME$UBX_20; Binding factors: Antp . BS 220 305 R01888; DROME$UBX_16; Binding factors: Eve , Zen-1 BS , Zen-2 . BS 78635 0 R04948; DROME$UBX_21; Binding factors: Zeste , Zeste BS . BS 78651 0 R04949; DROME$UBX_22; Binding factors: Zeste , Zeste BS . BS 78688 0 R04950; DROME$UBX_23; Binding factors: Zeste , Zeste BS . XX DR EMBL: U31961; DM31961. DR EMBL: X05427; DMUBXG5. DR TRANSPATH: G000124. XX RN [1] RX MEDLINE; 20143578. RA Kusanagi K., Inoue H., Ishidou Y., Mishima H. K., Kawabata M., Miyazono K. RT Characterization of a bone morphogenetic protein-responsive Smad-binding RT element. RL Mol. Biol. Cell 11:555-565 (2000). RN [2] RX MEDLINE; 20525587. RA Dai H., Hogan C., Gopalakrishnan B., Torres-Vazquez J., Nguyen M., Park S., RA Raftery L. A., Warrior R., Arora K. RT The zinc finger protein schnurri acts as a Smad partner in mediating the RT transcriptional response to decapentaplegic. RL Dev. Biol. 227:373-387 (2000). RN [3] RX MEDLINE; 97373960. RA Kim J., Johnson K., Chen H. J., Carroll S., Laughon A. RT Drosophila mad binds to DNA and directly mediates activation of vestigial RT by Decapentaplegic RL Nature 388:304-308 (1997). RN [4] RX MEDLINE; 97236498. RA Riese J., Yu X., Munnerlyn A., Eresh S., Hsu S.-C., Grosschedl R., Bienz M. RT LEF-1, a nuclear factor coordinating signaling inputs from wingless and RT decapentaplegic RL Cell 88:777-787 (1997). RN [5] RX MEDLINE; 92123185. RA Chen J. D., Chan C. Sh., Pirrotta V. RT Conserved DNA binding and self-association domains of the Drosophila zeste RT protein RL Mol. Cell. Biol. 12:598-608 (1992). RN [6] RX MEDLINE; 91224093. RA Qian S., Capovilla M., Pirrotta V. RT The bx region enhancer, a distant cis-control element of the Drosophila Ubx RT gene and its regulation by hunchback and other segmentation genes RL EMBO J. 10:1415-1425 (1991). RN [7] RX MEDLINE; 90361011. RA Bickel S., Pirrotta V. RT Self-association of the Drosophila zeste protein is responsible for RT transvection effects RL EMBO J. 9:2959-2967 (1990). RN [8] RX MEDLINE; 89336775. RA Biggin M. D., Tjian R. RT A Purified Drosophila Homeodomain Protein Represses Transcription In Vitro RL Cell 58:433-440 (1989). RN [9] RX MEDLINE; 89288289. RA Winslow G. M., Hayashi S., Krasnow M., Hogness D. S., Scott M. P. RT Functional Activation by the Antennapedia and fushi tarazu Proteins in RT Cultured Drosophila Cells RL Cell 57:1017-1030 (1989). RN [10] RX MEDLINE; 90108664. RA Dynlacht B. D., Attardi L. D., Admon A., Freeman M., Tjian R. RT Functional analysis of NTF-1, a developmentally regulated Drosophila RT transcription factor that binds neuronal cis elements RL Genes Dev. 3:1677-1688 (1989). RN [11] RX MEDLINE; 88223364. RA Biggin M. D., Tjian R. RT Transcription factors that activate the Ultrabithorax promoter in RT developmentally staged extracts RL Cell 53:699-711 (1988). RN [12] RX MEDLINE; 88223365. RA Biggin M. D., Bickel S., Benson M., Pirrotta V., Tjian R. RT Zeste encodes a sequence-specific transcription factor that activates the RT Ultrabithorax promoter in vitro RL Cell 53:713-722 (1988). RN [13] RX MEDLINE; 89091140. RA Benson M., Pirrotta V. RT The Drosophila zeste protein binds cooperatively to sites in many gene RT regulatory regions: implications for transvection and gene regulation RL EMBO J. 7:3907-3915 (1988). RN [14] RX MEDLINE; 88174703. RA Mansukhani A., Crickmore A., Sherwood P.W., Goldberg M. L. RT DNA-Binding Properties of the Drosophila melanogaster zeste Gene Product RL Mol. Cell. Biol. 8:615-623 (1988). XX // AC G000125 XX ID DROME$WHLO XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD WHLO XX DE white gene locus XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.7.2 XX BS -1321 -1306 R01599; DROME$WHLO_01; Binding factors: Zeste , BS Zeste . BS -1279 -1264 R04938; DROME$WHLO_02; Binding factors: Zeste , BS Zeste . BS -1203 0 R04939; DROME$WHLO_03; Binding factors: Zeste , BS Zeste . BS -1166 0 R04940; DROME$WHLO_04; Binding factors: Zeste , BS Zeste . BS -1136 0 R04941; DROME$WHLO_05; Binding factors: Zeste , BS Zeste . BS -401 0 R04942; DROME$WHLO_06; Binding factors: Zeste , Zeste BS . BS -371 0 R04943; DROME$WHLO_07; Binding factors: Zeste , Zeste BS . BS -90 0 R04944; DROME$WHLO_08; Binding factors: Zeste , Zeste BS . BS -73 0 R04945; DROME$WHLO_09; Binding factors: Zeste , Zeste BS . BS 1327 0 R04946; DROME$WHLO_10; Binding factors: Zeste , Zeste BS . BS 1376 0 R04947; DROME$WHLO_11; Binding factors: Zeste , Zeste BS . XX DR EMBL: X02974; DMWHITE. DR TRANSPATH: G000125. XX RN [1] RX MEDLINE; 89091140. RA Benson M., Pirrotta V. RT The Drosophila zeste protein binds cooperatively to sites in many gene RT regulatory regions: implications for transvection and gene regulation RL EMBO J. 7:3907-3915 (1988). RN [2] RX MEDLINE; 88174703. RA Mansukhani A., Crickmore A., Sherwood P.W., Goldberg M. L. RT DNA-Binding Properties of the Drosophila melanogaster zeste Gene Product RL Mol. Cell. Biol. 8:615-623 (1988). XX // AC G000126 XX ID DROME$YP1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD yp1 XX DE yolk protein 1 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.3.1 XX BS -303 -295 R03402; DROME$YP1_02; Binding factors: DSXF , DSXM BS . BS -279 -260 R03403; DROME$YP1_03; Binding factors: DSXF , DSXM BS . BS -235 -227 R03404; DROME$YP1_04; Binding factors: DSXF , DSXM BS . BS 148 179 R01602; DROME$YP1_01; Binding factors: YPF1 . XX DR EMBL: X01524; DMYOLK1. DR TRANSPATH: G000126. XX RN [1] RX MEDLINE; 93138387. RA Coschigano K. T., Wensink P. C. RT Sex-specific transcriptional regulation by the male and female doublesex RT proteins of Drosophila RL Genes Dev. 7:42-54 (1993). RN [2] RX MEDLINE; 91330881. RA Burtis K. C., Coschigano K. T., Baker B. S., Wensink P. C. RT The Doublesex proteins of Drosophila melanogaster bind directly to a RT sex-specific yolk protein gene enhancer RL EMBO J. 10:2577-2582 (1991). RN [3] RX MEDLINE; 89174807. RA Mitsis P. G., Wensink P. C. RT Identification of Yolk Protein Factor 1, a Sequence-specific DNA-binding RT Protein from Drosophila melanogaster RL J. Biol. Chem. 264:5188-5194 (1989). XX // AC G000127 XX ID DROME$ZEN XX DT 14.06.1995 (created); dbo. DT 16.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD zen XX DE zerknuellt XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BS -1549 -1541 R01723; DROME$ZEN_01; Binding factors: Dl . BS -1295 -1286 R02852; DROME$ZEN_02; Binding factors: Dl . BS -1227 -1217 R02853; DROME$ZEN_03; Binding factors: Dl . BS -1177 -1168 R02854; DROME$ZEN_04; Binding factors: Dl . XX DR EMBL: L18923; DMCOREP. DR EMBL: S78213; S78213. DR TRANSPATH: G000127. XX RN [1] RX MEDLINE; 91105859. RA Ip Y. T., Kraut R., Levine M., Rushlow C. A. RT The dorsal morphogen if a sequence-specific DNA-binding protein that RT interacts with a long-range repression element in Drosophila RL Cell 64:439-446 (1991). RN [2] RX MEDLINE; 91292522. RA Thisse C., Perrin-Schmitt F., Stoetzel C., Thisse B. RT Sequence-specific transactivation of the Drosophila twist gene by the RT dorsal gene product RL Cell 65:1191-1201 (1991). RN [3] RX MEDLINE; 92009178. RA Jiang J., Kosman D., Ip Y. T., Levine M. RT The dorsal morphogen gradient regulates the mesoderm determinant twist in RT early Drosophila embryos RL Genes Dev. 5:1881-1891 (1991). XX // AC G000128 XX ID DROOR$ADH XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Adh XX DE alcohol dehydrogenase XX OS fruit fly, Drosophila orena OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; OC drosophilidae XX BC 3.1.4.3 XX BS -666 -640 R01970; DROOR$ADH_10. BS -606 -584 R01971; DROOR$ADH_11. BS -580 -559 R01974; DROOR$ADH_12. BS -569 -544 R01953; DROOR$ADH_01. BS -532 -506 R01954; DROOR$ADH_02. BS -486 -472 R01975; DROOR$ADH_13. BS -475 -457 R01957; DROOR$ADH_03. BS -424 -400 R01958; DROOR$ADH_04. BS -403 -388 R01979; DROOR$ADH_14. BS -266 -246 R01980; DROOR$ADH_15. BS -240 -224 R01982; DROOR$ADH_16. BS -219 -208 R01983; DROOR$ADH_17. BS -207 -182 R01961; DROOR$ADH_05. BS -158 -133 R01962; DROOR$ADH_06. BS -146 -124 R01986; DROOR$ADH_18; Binding factors: Adf-1 . BS -125 -101 R01965; DROOR$ADH_07. BS -97 -60 R01987; DROOR$ADH_19. BS -86 -48 R01966; DROOR$ADH_08; Binding factors: Adf-1 . BS -45 -21 R01967; DROOR$ADH_09. XX DR EMBL: Z00032; DOADHG. DR TRANSPATH: G000128. DR BRENDA: 1.1.1.1. XX RN [1] RX MEDLINE; 90136567. RA Moses K., Heberlein U., Ashburner M. RT The Adh gene promoters of Drosophila melanogaster and Drosophila orena are RT functionally conserved and share features of sequence structure and RT nuclease-protected sites RL Mol. Cell. Biol. 10:539-548 (1990). XX // AC G000129 XX ID DUCK$BAG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-BA XX DE betaA-globin XX OS duck, Cairina moschata OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; anseriformes; anatidae XX BC 6.1.3.9.9 XX BS 1780 1804 R04117; DUCK$BAG_01. BS 1824 1846 R04118; DUCK$BAG_02. BS 1848 1920 R04119; DUCK$BAG_03. BS 1927 1938 R04120; DUCK$BAG_04. XX DR EMBL: X15739; CMBGA2B2. XX RN [1] RX MEDLINE; 91365254. RA Cvekl A., Horska K., Vlcek C., Paces V. RT Protein-binding A+T-rich motifs flank the duck betaA-globin enhancer RL Gene 103:253-257 (1991). XX // AC G000130 XX ID DUCK$HH5 XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H5 XX DE histone 5 XX OS duck, Cairina moschata OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; OC neognathae; anseriformes; anatidae XX BC 6.1.2.1.1 XX BS 34 53 R02078; DUCK$HH5_02; Binding factors: USF . BS 500 520 R00693; DUCK$HH5_01; Binding factors: USF1 , USF BS . XX DR EMBL: X01065; CMHISH5. DR TRANSPATH: G000130. XX RN [1] RX MEDLINE; 92167267. RA Bungert J., Kober I., Duering F., Seifart K. H. RT Transcription factor eUSF is an essential component of isolated RT transcription complexes on the duck histone H5 gene and it mediates the RT interaction of TFIID with a TATA-deficient promoter RL J. Mol. Biol. 223:885-898 (1992). RN [2] RX MEDLINE; 90206782. RA During F., Gerhold H., Seifart K. H. RT Transcription factor USF from duck erythrocytes transactivates expression RT of the histone H5 gene invitro by interacting with an intragenic sequence RL Nucleic Acids Res. 18:1225-1231 (1990). XX // AC G000131 XX ID EBV$BCR2 XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD BC-R2 promoter XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX BC 6.3.2 XX BS 11761 11812 R02928; EBV$BCR2_01. BS 11843 11858 R02929; EBV$BCR2_02. XX DR EMBL: V01555; EBV. DR EMBL: M80517; HEHS4B958. XX RN [1] RX MEDLINE; 91114697. RA Walls D., Perricaudet M. RT Novel downstream elements upregulate transcription initiated from an RT Epstein-Barr virus latent promoter RL EMBO J. 10:143-151 (1991). XX // AC G000132 XX ID EBV$BHLF1 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD BHLF1 XX DE MinL XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX BC 6.3.2 XX BS -141 0 R03178; EBV$BHLF1_01; Binding factors: Zta . BS -108 0 R03179; EBV$BHLF1_02; Binding factors: Zta . BS -78 0 R03180; EBV$BHLF1_03; Binding factors: Zta . BS -53 0 R03181; EBV$BHLF1_04; Binding factors: Zta . BS -30 0 R03182; EBV$BHLF1_05; Binding factors: TBP . XX DR EMBL: V01555; EBV. DR TRANSPATH: G000132. XX RN [1] RX MEDLINE; 92090724. RA Lieberman P. M., Berk A. J. RT The Zta trans-activator protein stabilizes TFIID association with promoter RT DNA by direct protein-protein interaction RL Genes Dev. 5:2441-2454 (1991). XX // AC G000133 XX ID EBV$BMLF1 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD BMLF1 XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX BC 6.3.2 XX BS -414 -349 R04003; EBV$BMLF1_01; Binding factors: R . XX DR EMBL: V01555; EBV. DR TRANSPATH: G000133. XX RN [1] RX MEDLINE; 92085417. RA Gruffat H., Duran N., Buisson M., Wild F., Buckland R., Sergeant A. RT Characterization of an R-binding site mediating the R-induced activation of RT the Epstein-Barr virus BMLF1 promoter RL J. Virol. 66:46-52 (1992). XX // AC G000134 XX ID EBV$BMRF1 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD BMRF1 XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX BC 6.3.2 XX BS 79760 79812 R04261; EBV$BMRF1_01; Binding factors: Zta . XX DR EMBL: V01555; EBV. DR TRANSPATH: G000134. XX RN [1] RX MEDLINE; 92107162. RA Kenney S. C., Holley-Guthrie E., Quinlivan E. B., Gutsch D., Zhang Q., RA Bender T., Giot J.-F., Sergeant A. RT The cellular oncogene c-myb can interact synergistically with the RT Epstein-Barr virus BZLF1 transactivator in lymphoid cells RL Mol. Cell. Biol. 12:136-146 (1992). XX // AC G000135 XX ID EBV$BRLF1 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD BRLF1 XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX BC 6.3.2 XX BS empty empty R00195; EBV$BRLF1_02. BS -160 -147 R00194; EBV$BRLF1_01; Binding factors: MBF1 . XX DR EMBL: V01555; EBV. DR TRANSPATH: G000135. XX RN [1] RX MEDLINE; 90156519. RA Flemington E., Speck S. H. RT Identification of Phorbol Ester Responsive Elements in the Promoter of RT Epstein-Barr Virus Putative Lytic Switch Gene BZLF1 RL J. Virol. 64:1217-1226 (1990). XX // AC G000137 XX ID EBV$BSLF2 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD BSLF2 + BMLF1 XX DE BC-R2 promoter XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX BC 6.3.2 XX BS 84425 84439 R00196; EBV$BSLF2_01; Binding factors: Zta . XX DR EMBL: V01555; EBV. DR TRANSPATH: G000137. XX RN [1] RX MEDLINE; 92085440. RA Sinclair A. J., Brimmell M., Farrell P. J. RT Reciprocal antagonism of steroid hormones and BZLF1 in switch between RT Epstein-Barr virus latent and productive cycle gene expression RL J. Virol. 66:70-77 (1992). RN [2] RX MEDLINE; 91303651. RA Taylor N., Flemington E., Kolman J. L., Baumann R. P., Speck S. H., Miller RA G. RT ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding RT specificities for sites in the Epstein-Barr virus BZLF1 promoter RL J. Virol. 65:4033-4041 (1991). RN [3] RX MEDLINE; 91237800. RA Young L. S., Lau R., Rowe M., Niedobitek G., Packham G., Shanahan F., Rowe RA D. T., Greenspan D., Greenspan J. S., Rickinson A. B., Farrell P. J. RT Differentiation-associated expression of the Epstein-Barr BZLF1 RT transactivator protein in oral hairy leukoplakia RL J. Virol. 65:2868-2874 (1991). RN [4] RX MEDLINE; 89231610. RA Farrell P. J., Rowe D. T., Rooney C. M., Kouzarides T. RT Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus RT AP-1 site and is related to c-fos RL EMBO J. 8:127-132 (1989). XX // AC G000138 XX ID EBV$BZLF1 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD BZLF1 XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX BC 6.3.2 XX BS empty empty R03411; EBV$BZLF1_06. BS empty empty R03412; EBV$BZLF1_07; Binding factors: SRF . BS -200 -165 R00197; EBV$BZLF1_01; Binding factors: MBF1 , MEF-2 BS . BS -157 -133 R00198; EBV$BZLF1_02; Binding factors: MBF1 , MEF-2 BS . BS -136 -120 R03344; EBV$BZLF1_04; Binding factors: Zta . BS -122 -104 R03345; EBV$BZLF1_05; Binding factors: Zta . BS -98 -55 R00199; EBV$BZLF1_03; Binding factors: c-Fos , c-Jun BS , MBF1 , MEF-2 . XX DR EMBL: V01555; EBV. DR EMBL: M20820; HEHS4HET. DR EMBL: M17547; HEHS4IET. DR TRANSPATH: G000138. XX RN [1] RX MEDLINE; 97162288. RA Liu S., Liu P., Borras A., Chatila T., Speck S. H. RT Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is RT mediated via a novel pathway involving a MEF2 family receptor RL EMBO J. 16:143-153 (1997). RN [2] RX MEDLINE; 91303651. RA Taylor N., Flemington E., Kolman J. L., Baumann R. P., Speck S. H., Miller RA G. RT ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding RT specificities for sites in the Epstein-Barr virus BZLF1 promoter RL J. Virol. 65:4033-4041 (1991). RN [3] RX MEDLINE; 91251217. RA Montalvo E. A., Shi Y., Shenk T. E., Levine A. J. RT Negative regulation of the BZLF1 promoter of Epstein-Barr virus RL J. Virol. 65:3647-3655 (1991). RN [4] RX MEDLINE; 90156519. RA Flemington E., Speck S. H. RT Identification of Phorbol Ester Responsive Elements in the Promoter of RT Epstein-Barr Virus Putative Lytic Switch Gene BZLF1 RL J. Virol. 64:1217-1226 (1990). XX // AC G000139 XX ID EBV$DSL XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD DSL XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX BC 6.3.2 XX BS -976 -970 R00295; EBV$DSL_01; Binding factors: Zta . BS -859 -840 R00296; EBV$DSL_02; Binding factors: Zta . BS -711 -682 R00297; EBV$DSL_03; Binding factors: Zta . BS -148 -132 R00298; EBV$DSL_04; Binding factors: Zta . BS -115 -101 R00299; EBV$DSL_05; Binding factors: Zta . BS -98 -84 R00300; EBV$DSL_06. BS -77 -62 R00301; EBV$DSL_07; Binding factors: Zta . BS -59 -42 R00302; EBV$DSL_08; Binding factors: Zta . XX DR EMBL: V01555; EBV. DR TRANSPATH: G000139. XX RN [1] RX MEDLINE; 90156511. RA Lieberman P. M., Hardwick J. M., Sample J., Hayward G. S., Hayward S. D. RT The Zta Transactivator Involved in Induction of Lytic Cycle Gene Expression RT in Epstein-Barr Virus-Infected Lymphocytes Binds to Both AP-1 and ZRE Sites RT in Target Promoter and Enhancer Regions RL J. Virol. 64:1143-1155 (1990). XX // AC G000140 XX ID EBV$ORIP XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD oriP XX DE latent origin of replication XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX BC 6.3.2 XX BS 35 58 R01178; EBV$ORIP_01; Binding factors: EBNA-1 . XX DR TRANSPATH: G000140. XX RN [1] RX MEDLINE; 89343993. RA Kimball A. S., Milman G., Tullius T. D. RT High-Resolution Footprints of the DNA-Binding Domain of Epstein-Barr Virus RT Nuclear Antigen 1 RL Mol. Cell. Biol. 9:2738-2742 (1989). XX // AC G000141 XX ID EBV$IR4 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD IR4 XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX BC 6.3.2 XX BS -887 -867 R02813; EBV$IR4_01. BS -854 -833 R02814; EBV$IR4_02. BS -826 -810 R02815; EBV$IR4_03. BS -800 -763 R02816; EBV$IR4_04; Binding factors: R . BS -780 -741 R02817; EBV$IR4_05; Binding factors: R . BS -760 -741 R02818; EBV$IR4_06; Binding factors: R . XX DR EMBL: V01555; EBV. DR TRANSPATH: G000141. XX RN [1] RX MEDLINE; 91252210. RA Manet E., Rigolet A., Gruffat H., Giot J., Sergeant A. RT Domains of the Epstein-Barr virus (EBV) transcription factor R required for RT dimerization, DNA binding and activation RL Nucleic Acids Res. 19:2661 (1991). RN [2] RX MEDLINE; 91088254. RA Gruffat H., Manet E., Rigolet A., Sergeant A. RT The enhancer factor R of Epstein-Barr virus (EBV) is a sequence-specific RT DNA binding protein RL Nucleic Acids Res. 18:6835 (1990). XX // AC G000142 XX ID FELV$FELV XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD FeLV XX DE feline leukemia virus XX OS FeLV, feline leukemia virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; mammalian type C OC oncoviruses XX BC 6.2.1.2 XX BS -277 -271 R01656; FELV$FELV_01; Binding factors: LVb-binding factor BS , LVb-binding factor . BS -269 -259 R01657; FELV$FELV_02; Binding factors: core-binding factor BS . BS -248 -234 R01658; FELV$FELV_03; Binding factors: NF-1 . BS -234 -228 R01659; FELV$FELV_04; Binding factors: GR . BS -186 -175 R01660; FELV$FELV_05; Binding factors: FLV-1 . XX DR EMBL: M87886; FCVFAIDS. DR EMBL: M37971; FCVFELV. DR EMBL: M18248; REFCVF3A. DR EMBL: M18247; REFCVF6A. DR EMBL: K01209; REGAENV. DR EMBL: K01803; REGP. DR EMBL: K01208; RESTENV. DR TRANSPATH: G000142. XX RN [1] RX MEDLINE; 90204679. RA Fulton R., Plumb M., Shield L., Neil J. C. RT Structural Diversity and Nuclear Protein Binding Sites in the Long Terminal RT Repeats of Feline Leukemia Virus RL J. Virol. 64:1675-1682 (1990). XX // AC G000143 XX ID FMULV$FMULV XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD F-MuLV XX OS F-MuLV, friend murine leukemia virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; mammalian type C OC oncoviruses; murine leukemia viruses XX BC 6.2.1.2 XX BS -54 -34 R04069; FMULV$FMULV_01; Binding factors: PU.1 , PU.1 BS . XX DR TRANSPATH: G000143. XX RN [1] RX MEDLINE; 93275657. RA Zhang L., Lemarchandel V., Romeo P.-H., Ben-David Y., Greer P., Bernstein A. RT The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing`s sarcoma, RT encodes a transcriptional activator with DNA-binding specifities distinct RT from other Ets family members RL Oncogene 8:1621-1630 (1993). XX // AC G000144 XX ID FSV$FSV XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD FSV XX DE Fujinami sarcoma virus XX OS FSV, fujinami sarcoma virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; avian type C OC oncoviruses; avian sarcoma viruses XX BS -214 -196 R00480; FSV$FSV_01; Binding factors: C/EBPalpha . XX DR EMBL: J02194; REFSV. DR TRANSPATH: G000144. XX RN [1] RX MEDLINE; 89261719. RA Ryden T. A., Beemon K. RT Avian Retroviral Long Terminal Repeats Bind CCAAT/Enhancer-Binding Protein RL Mol. Cell. Biol. 9:1155-1164 (1989). XX // AC G000145 XX ID FUSO$CUT XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CUTA XX DE cutinase XX OS Fusarium solani OC Eukaryota; Fungi; Ascomycota; Euascomycetes; Pyrenomycetes; Hypocreales; OC Hypocreaceae; mitosporic Hypocreaceae; Fusarium. XX BS -360 -225 R03494; FUSO$CUT_01. XX RN [1] RX MEDLINE; 91376113. RA Bajar A., Podila G. K., Kolattukudy P. E. RT Identification of a fungal cutinase promoter that is inducible by a plant RT signal via a phosphorylated trans-acting factor RL Proc. Natl. Acad. Sci. USA 88:8208-8212 (1991). XX // AC G000146 XX ID FY$CDC18 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD cdc18 XX OS fission yeast, Schizosaccharomyces pombe OC Eukaryota; Fungi; Ascomycota; Archiascomycetes; Schizosaccharomycetales; OC Schizosaccharomycetaceae; Schizosaccharomyces. XX BS -281 -119 R03782; FY$CDC18_01; Binding factors: res2 , cdc10 BS . XX DR TRANSPATH: G000146. XX RN [1] RX MEDLINE; 95011588. RA Zhu Y., Takeda T., Nasmyth K., Jones N. RT pct1+, which encodes a new DNA-binding partner of p85cdc10, is required for RT meiosis in the fission yeast Schizosaccharomyces pombe RL Genes Dev. 8:885-898 (1994). XX // AC G000147 XX ID FY$CDC22 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD cdc22 XX OS fission yeast, Schizosaccharomyces pombe OC Eukaryota; Fungi; Ascomycota; Archiascomycetes; Schizosaccharomycetales; OC Schizosaccharomycetaceae; Schizosaccharomyces. XX BS -539 -402 R03783; FY$CDC22_01; Binding factors: res2 , cdc10 BS . XX DR TRANSPATH: G000147. XX RN [1] RX MEDLINE; 94147989. RA Hofmann J. F. X., Beach D. RT cdt1 is an essential target of the Cdc10/Sct1 transcription factor: RT requirement for DNA replication and inhibition of mitosis RL EMBO J. 13:425-434 (1994). RN [2] RX MEDLINE; 95011588. RA Zhu Y., Takeda T., Nasmyth K., Jones N. RT pct1+, which encodes a new DNA-binding partner of p85cdc10, is required for RT meiosis in the fission yeast Schizosaccharomyces pombe RL Genes Dev. 8:885-898 (1994). XX // AC G000148 XX ID FY$CDT1 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD cdt1 XX OS fission yeast, Schizosaccharomyces pombe OC Eukaryota; Fungi; Ascomycota; Archiascomycetes; Schizosaccharomycetales; OC Schizosaccharomycetaceae; Schizosaccharomyces. XX BS -310 -302 R03794; FY$CDT1_01. BS -282 -257 R03795; FY$CDT1_02; Binding factors: cdc10 . BS -244 -231 R03796; FY$CDT1_03. XX DR TRANSPATH: G000148. XX RN [1] RX MEDLINE; 94147989. RA Hofmann J. F. X., Beach D. RT cdt1 is an essential target of the Cdc10/Sct1 transcription factor: RT requirement for DNA replication and inhibition of mitosis RL EMBO J. 13:425-434 (1994). XX // AC G000149 XX ID FY$MAT1 XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD mat1 XX DE mating type locus XX OS fission yeast, Schizosaccharomyces pombe OC Eukaryota; Fungi; Ascomycota; Archiascomycetes; Schizosaccharomycetales; OC Schizosaccharomycetaceae; Schizosaccharomyces. XX BS 143 145 R03706; FY$MAT1_01; Binding factors: sap1 . BS 160 170 R03707; FY$MAT1_02; Binding factors: sap1 . XX DR EMBL: X59127; SPMAT1SMT. DR TRANSPATH: G000149. XX RN [1] RX MEDLINE; 94158880. RA Arcangioli B., Copeland T. D., Klar A. J. S. RT Sap1, a protein that binds to sequences required for mating-type switching, RT is essential for viability in Schizosaccharomyces pombe RL Mol. Cell. Biol. 14:2058-2065 (1994). RN [2] RX MEDLINE; 92007747. RA Arcangioli B., Klar A. J. S. RT A novel switch-acting site (SAS1) and its cognate binding factor (SAP1) RT required for efficient mat1 switching in Schizosaccharomyces pombe RL EMBO J. 10:3025-3032 (1991). XX // AC G000150 XX ID FY$MATP XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD matP XX OS fission yeast, Schizosaccharomyces pombe OC Eukaryota; Fungi; Ascomycota; Archiascomycetes; Schizosaccharomycetales; OC Schizosaccharomycetaceae; Schizosaccharomyces. XX BS 524 564 R04088; FY$MATP_01; Binding factors: ste11 . XX DR EMBL: X07643; SPMAT1P. DR TRANSPATH: G000150. XX RN [1] RX MEDLINE; 92038989. RA Sugimoto A., Iino Y., Maeda T., Watanabe Y., Yamamoto M. RT Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG RT motif that is a critical regulator of sexual development RL Genes Dev. 5:1990-1999 (1991). XX // AC G000151 XX ID FY$MEI2 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD mei2 XX OS fission yeast, Schizosaccharomyces pombe OC Eukaryota; Fungi; Ascomycota; Archiascomycetes; Schizosaccharomycetales; OC Schizosaccharomycetaceae; Schizosaccharomyces. XX BS -1522 -1505 R04087; FY$MEI2_01; Binding factors: ste11 . XX DR EMBL: X07180; SPMEI2. DR TRANSPATH: G000151. XX RN [1] RX MEDLINE; 92038989. RA Sugimoto A., Iino Y., Maeda T., Watanabe Y., Yamamoto M. RT Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG RT motif that is a critical regulator of sexual development RL Genes Dev. 5:1990-1999 (1991). XX // AC G000152 XX ID FY$SSP1 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD SSP1 XX OS fission yeast, Schizosaccharomyces pombe OC Eukaryota; Fungi; Ascomycota; Archiascomycetes; Schizosaccharomycetales; OC Schizosaccharomycetaceae; Schizosaccharomyces. XX BS -364 -325 R03751; FY$SSP1_01; Binding factors: hsf . XX DR EMBL: X59987; SPSSP1. DR TRANSPATH: G000152. XX RN [1] RX MEDLINE; 93140772. RA Gallo G. J., Prentice H., Kingston R. E. RT Heat shock factor is required for growth at normal temperatures in the RT fission yeast Schizosaccharomyces pombe RL Mol. Cell. Biol. 13:749-761 (1993). XX // AC G000153 XX ID GALV$GALV XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GALV XX DE gibbon ape leukemia virus XX OS GALV, gibbon ape leukemia virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; mammalian type C OC oncoviruses XX BC 6.2.1.2 XX BS 95 0 R00505; GALV$GALV_01. XX DR EMBL: K02989; RESEATR. XX RN [1] RX MEDLINE; 88038812. RA Quinn J. P., Holbrook N., Levens D. RT Binding of a Cellular Protein to the Gibbon Ape Leukemia Virus Enhancer RL Mol. Cell. Biol. 7:2735-2744 (1987). XX // AC G000155 XX ID HA$DHFR XX DT 14.06.1995 (created); dbo. DT 16.11.2000 (updated); sth. CO Copyright (C), Biobase GmbH. XX SD DHFR XX DE dihydrofolate reductase XX OS hamster, Cricetulus griseus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; cricetidae; cricetinae; cricetini XX BC 6.1.4.2 XX BS empty empty R04455; HA$DHFR_06; Binding factors: c-Myc , c-Myc BS , Max1 , Max . BS -197 -158 R01908; HA$DHFR_04; Binding factors: Sp1 . BS -158 -142 R01909; HA$DHFR_05; Binding factors: Sp1 . BS -136 0 R01801; HA$DHFR_01; Binding factors: E2F , p107 BS , cyclin A , cdk2 . BS -115 -95 R01802; HA$DHFR_02; Binding factors: Sp1 . BS -62 -51 R09550; HA$DHFR_07; Binding factors: E2F . BS -59 -51 R09551; HA$DHFR_08; Binding factors: E2F . XX DR EMBL: M13129; CGDHRA. DR EMBL: M14771; CSDHR5A. DR TRANSPATH: G000155. DR TRANSCOMPEL: C00226. DR BRENDA: 1.5.1.3; Cricetulus_griseus. DR TRRD: 00023. XX RN [1] RX MEDLINE; 97172529. RA Wells J. M., Illenye S., Magae J., Wu C. L., Heintz N. H. RT Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction RT of dhfr gene expression during the G1 to S phase transition RL J. Biol. Chem. 272:4483-4492 (1997). RN [2] RX MEDLINE; 96140431. RA Wells J., Held P., Illenye S., Heintz N. H. RT Protein-DNA interactions at the major and minor promoters of the RT divergently transcribed dhfr and rep3 genes during the chinese hamster RT ovary cell cycle RL Mol. Cell. Biol. 16:634-647 (1996). RN [3] RX MEDLINE; 95247766. RA Wade M., Blake M. C., Jambou R. C., Helin K., Harlow E., Azizkhan J. C. RT An inverted repeat motif stabilizes binding of E2F and enhances RT transcription of the dihydrofolate reductase gene RL J. Biol. Chem. 270:9783-9791 (1995). RN [4] RX MEDLINE; 93024378. RA Wade M., Kowalik T. F., Mudryj M., Huang E.-S., Azizkhan J. C. RT E2F mediates dihydrofolate reductase promoter activation and multiprotein RT complex formation in human cytomegalovirus infection RL Mol. Cell. Biol. 12:4364-4374 (1992). RN [5] RX MEDLINE; 91251204. RA Hiebert S. W., Blake M., Azizkhan J., Nevins J. R. RT Role of E2F transcription factor in E1A-mediated trans activation of RT cellular genes RL J. Virol. 65:3547-3552 (1991). RN [6] RX MEDLINE; 91061772. RA Blake M. C., Jambou R. C., Swick A. G., Kahn J. W., Azizkhan J. C. RT Transcriptional initiation is controlled by upstream GC-box interactions in RT a TATAA-less promoter RL Mol. Cell. Biol. 10:6632-6641 (1990). RN [7] RX MEDLINE; 90097916. RA Blake M. C., Azizkhan J. C. RT Transcription Factor E2F Is Required for Efficient Expression of the RT Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo RL Mol. Cell. Biol. 9:4994-5002 (1989). RN [8] RX MEDLINE; 90067928. RA Swick A. G., Blake M. C., Kahn J. W., Azizkhan J. C. RT Functional analysis of GC element binding and transcription in the hamster RT dihydrofolate reductase gene promoter RL Nucleic Acids Res. 17:9291-9304 (1989). XX // AC G000156 XX ID HA$H32 XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H3.2 XX DE histone 3.2 XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; cricetidae; cricetinae; cricetini XX BC 6.1.2.1.4 XX BS -244 -224 R00678; HA$H32_01; Binding factors: c-Jun , v-Jun BS . XX DR EMBL: M28265; M28265. DR TRANSPATH: G000156. DR TRRD: 00103. XX RN [1] RX MEDLINE; 89098959. RA Sharma A., Bos T. J., Pekkala-Flagan A., Vogt P. K., Lee A. S. RT Interaction of cellular factors related to the Jun oncoprotein with the RT promoter of a replication-dependent hamster histone H3.2 gene RL Proc. Natl. Acad. Sci. USA 86:491-495 (1989). XX // AC G000157 XX ID HA$HMGCR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD HMGCOAR XX DE HMG-CoA reductase XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; cricetidae; cricetinae; cricetini XX BC 6.1.4 XX BS -247 -223 R00708; HA$HMGCR_01. BS -201 -136 R00709; HA$HMGCR_02. BS -142 -103 R00710; HA$HMGCR_03. BS -98 -82 R00711; HA$HMGCR_04; Binding factors: USF . BS -62 -44 R00712; HA$HMGCR_05. BS -42 -13 R00713; HA$HMGCR_06. XX DR EMBL: M15960; MAHMGCOA. DR TRANSPATH: G000157. DR BRENDA: 1.1.1.88. XX RN [1] RX MEDLINE; 87231868. RA Osborne T. F., Gil G., Brown M. S., Kowal R. C., Goldstein J. L. RT Identification of promoter elements required for in vitro transcription of RT hamster 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene RL Proc. Natl. Acad. Sci. USA 84:3614-3618 (1987). XX // AC G000158 XX ID HBV$HBVE XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD HBV enhancer XX DE hepatitis B virus XX OS HBV, human hepatitis B virus OC viridae; ds-DNA enveloped viruses; hepadnaviridae XX BC 6.3.7 XX BS 881 900 R00630; HBV$HBVE_01. BS 972 991 R00631; HBV$HBVE_02; Binding factors: C/EBPalpha , BS C/EBPalpha . BS 1029 1048 R00632; HBV$HBVE_03; Binding factors: C/EBPalpha , BS C/EBPalpha . BS 1103 1120 R00633; HBV$HBVE_04; Binding factors: NF-1 , NF-1 BS . BS 1117 1223 R02570; HBV$HBVE_14; Binding factors: EF-C , EF-C BS . BS 1119 1133 R03992; HBV$HBVE_26. BS 1138 1150 R03934; HBV$HBVE_05; Binding factors: RXR-alpha . BS 1151 1177 R00635; HBV$HBVE_06; Binding factors: C/EBPalpha , BS c-abl . BS 1167 1191 R02056; HBV$HBVE_13; Binding factors: C/EBPalpha . BS 1168 1195 R00636; HBV$HBVE_07; Binding factors: NF-1 . BS 1181 1204 R00637; HBV$HBVE_08; Binding factors: AP-1 , AP-1 BS , C/EBPalpha , C/EBPalpha , EF-C , EF-C BS , EBP40 , EBP45 . BS 1186 1195 R00638; HBV$HBVE_09; Binding factors: TGT3 . BS 1186 1209 R00639; HBV$HBVE_10; Binding factors: E . BS 1186 1199 R04045; HBV$HBVE_27; Binding factors: CREB , CRE-BP1 BS , pX . BS 1216 1244 R00640; HBV$HBVE_11; Binding factors: NF-1 . BS 1599 1620 R02737; HBV$HBVE_15; Binding factors: C/EBPalpha . BS 1619 1632 R02738; HBV$HBVE_16. BS 1637 1666 R02739; HBV$HBVE_17; Binding factors: C/EBPalpha , BS protein a , protein b . BS 1645 1704 R02741; HBV$HBVE_19. BS 1658 1669 R00641; HBV$HBVE_12; Binding factors: CPBP . BS 1675 1690 R02740; HBV$HBVE_18; Binding factors: C/EBPalpha . BS 1708 1743 R02742; HBV$HBVE_20; Binding factors: protein c , BS protein d . BS 1711 1730 R02743; HBV$HBVE_21; Binding factors: C/EBPalpha . BS 1729 1756 R02747; HBV$HBVE_25. BS 1749 1779 R02744; HBV$HBVE_22; Binding factors: C/EBPalpha . BS 1801 1827 R02745; HBV$HBVE_23; Binding factors: C/EBPalpha . BS 1833 1849 R02746; HBV$HBVE_24; Binding factors: C/EBPalpha . XX DR EMBL: X68292; HBVDNA. DR EMBL: D00329; HPBADW1. DR EMBL: M57663; HPBADWZCG. DR EMBL: X51970; HVHEPB. DR EMBL: X02496; XXHEPAV. DR TRANSPATH: G000158. DR TRRD: 00114. XX RN [1] RX MEDLINE; 92274444. RA Dikstein R., Heffetz D., Ben-Neriah Y., Shaul Y. RT c-abl has a sequence-specific enhancer binding acitivity RL Cell 69:751-757 (1992). RN [2] RX MEDLINE; 93028404. RA Huan B., Siddiqui A. RT Retinoid X receptor RXRalpha binds to and trans-activates the hepatitis B RT virus enhancer RL Proc. Natl. Acad. Sci. USA 89:9059-9063 (1992). RN [3] RX MEDLINE; 92084734. RA Petropoulos I., Auge-Gouillou C., Zakin M. M. RT Characterization of the active part of the human transferrin gene enhancer RT and purification of two liver nuclear factors interacting with the TGTTTGC RT motif present in this region RL J. Biol. Chem. 266:24220-24225 (1991). RN [4] RX MEDLINE; 92046330. RA Guo W., Bell K. D., Ou J.-H. RT Characterization of the hepatitis B virus EnhI enhancer and X promoter RT complex RL J. Virol. 65:6686-6692 (1991). RN [5] RX MEDLINE; 92017779. RA Yuh C.-H., Ting L.-P. RT C/EBP-like proteins binding to the functional box-alpha and box-beta of the RT second enhancer of hepatitis B virus RL Mol. Cell. Biol. 11:5044-5052 (1991). RN [6] RX MEDLINE; 91219459. RA Trujillo M. A., Letovsky J., Maguire H. F., Lopez-Cabrera M., Siddiqui A. RT Functional analysis of a liver-specific enhancer of the hepatitis B virus RL Proc. Natl. Acad. Sci. USA 88:3797-3801 (1991). RN [7] RX MEDLINE; 91227910. RA Maguire H. F., Hoeffler J. P., Siddiqui A. RT HBV X protein alters the DNA binding specificity of CREB and ATF-2 by RT protein-protein interactions RL Science 252:842-844 (1991). RN [8] RX MEDLINE; 91306473. RA Lopez-Cabrera M., Letovsky J., Hu K.-Q., Siddiqui A. RT Transcriptional factor C/EBP binds to and transactivates the enhancer RT element II of the hepatitis B virus RL Virology 183:825-829 (1991). RN [9] RX MEDLINE; 91220738. RA Garcia A. D., Ostapchuk P., Hearing P. RT Methylation-dependent and -independent DNA binding of nuclear factor EF-C RL Virology 182:857-860 (1991). RN [10] RX MEDLINE; 91065865. RA Zhou D.-X., Yen T. S. B. RT Differential regulation of the hepatitis B virus surface gene promoters by RT a second viral enhancer RL J. Biol. Chem. 265:20731-20734 (1990). RN [11] RX MEDLINE; 90318416. RA Dikstein R., Faktor O., Shaul Y. RT Hierarchic and Cooperative Binding of the Rat Liver Nuclear Protein C/EBP RT at the Hepatitis B Virus Enhancer RL Mol. Cell. Biol. 10:4427-4430 (1990). RN [12] RX MEDLINE; 90311344. RA Lopez-Cabrera M., Letovsky J., Hu K.-Q., Siddiqui A. RT Multiple liver-specific factors bind to the hepatitis B virus RT core/pregenomic promoter: Trans-activation and repression by CCAAT/enhancer RT binding protein RL Proc. Natl. Acad. Sci. USA 87:5069-5073 (1990). RN [13] RX MEDLINE; 90287159. RA Dikstein R., Faktor O., Ben-Levy R., Shaul Y. RT Functional Organization of the Hepatitis B Virus Enhancer RL Mol. Cell. Biol. 10:3683-3689 (1990). RN [14] RX MEDLINE; 90108681. RA Friedman A. D., Landschulz W. H., McKnight S. L. RT CCAAT/enhancer binding protein activates the promoter of the serum albumin RT gene in cultured hepatoma cells RL Genes Dev. 3:1314-1322 (1989). RN [15] RX MEDLINE; 89261813. RA Ben-Levy R., Faktor O., Berger I., Shaul Y. RT Cellular Factors That Interact with the Hepatitis B Virus Enhancer RL Mol. Cell. Biol. 9:1804-1809 (1989). RN [16] RX MEDLINE; 89384536. RA Ostapchuk P., Scheirle G., Hearing P. RT Binding of Nuclear Factor EF-C to a Functional Domain of the Hepatitis B RT Virus Enhancer Region RL Mol. Cell. Biol. 9:2787-2797 (1989). RN [17] RX MEDLINE; 89186916. RA Landschulz W. H., Johnson P. F., McKnight S. L. RT The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite RL Science 243:1681-1688 (1989). RN [18] RX MEDLINE; 89218976. RA Karpen S., Banerjee R., Zelent A., Price P., Acs G. RT Identification of protein-binding sites in the hepatitis B virus enhancer RT and core promoter domains RL Mol. Cell. Biol. 8:5159-5165 (1988). RN [19] RX MEDLINE; 88004398. RA Shaul Y., Ben-Levy R. RT Multiple nuclear proteins in liver cells are bound to hepatitis B virus RT enhancer element and its upstream sequences RL EMBO J. 6:1913-1920 (1987). XX // AC G000160 XX ID HBV$S XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD S promoter XX DE major surface gene XX OS HBV, human hepatitis B virus OC viridae; ds-DNA enveloped viruses; hepadnaviridae XX BC 6.3.7 XX BS empty empty R03892; HBV$S_01. BS empty empty R03893; HBV$S_02. BS empty empty R03894; HBV$S_03. BS empty empty R03895; HBV$S_04. BS empty empty R03896; HBV$S_05. XX DR EMBL: X70185; HBVXCPS. XX RN [1] RX MEDLINE; 92078220. RA Zhou D.-X., Yen T. S. B. RT The hepatitis B virus S promoter comprises a CCAAT motif and two initiation RT regions RL J. Biol. Chem. 266:23416-23421 (1991). XX // AC G000161 XX ID HBV$SP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD SP XX DE large surface protein XX OS HBV, human hepatitis B virus OC viridae; ds-DNA enveloped viruses; hepadnaviridae XX BC 6.3.7 XX BS -93 -68 R01807; HBV$SP_01; Binding factors: HNF-1A , HNF-1B BS , HNF-1C . XX DR EMBL: V00866; HBVADW. DR EMBL: X02763; HBVADW2. DR EMBL: X68292; HBVDNA. DR EMBL: D00329; HPBADW1. DR EMBL: D00330; HPBADW2. DR EMBL: D00331; HPBADW3. DR EMBL: M54923; HPBADWZ. DR EMBL: J02202; NCADYW. DR TRANSPATH: G000161. XX RN [1] RX MEDLINE; 90097936. RA Chang H.-K., Wang B.-Y., Yuh C.-H., Wei C.-L., Ting L.-P. RT A Liver-Specific Nuclear Factor Interacts with the Promoter Region of the RT Large Surface Protein Gene of Human Hepatitis B Virus RL Mol. Cell. Biol. 9:5189-5197 (1989). XX // AC G000162 XX ID HBV$SA XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD S gene XX DE surface antigen XX OS HBV, human hepatitis B virus OC viridae; ds-DNA enveloped viruses; hepadnaviridae XX BC 6.3.7 XX BS -93 -69 R01913; HBV$SA_02; Binding factors: AFP1 , HNF-1A BS , HNF-1B , HNF-1C . BS -65 -47 R03010; HBV$SA_03; Binding factors: POU2F1 . BS 3004 3025 R01367; HBV$SA_01; Binding factors: NF-1 . XX DR EMBL: V00867; HBVADR. DR EMBL: X14193; HBVADRM. DR EMBL: X04615; HEHBVAYR. DR EMBL: S50225; S50225. DR TRANSPATH: G000162. DR TRANSCOMPEL: C00048. XX RN [1] RX MEDLINE; 91141483. RA Zhou D.-X., Yen T. S. B. RT The ubiquitous transcription factor Oct-1 and the liver-specific factor RT HNF-1 are both required to activate transcription of a hepatitis B virus RT promoter RL Mol. Cell. Biol. 11:1353-1359 (1991). RN [2] RX MEDLINE; 90098847. RA Nakao K., Miyao Y., Ohe Y., Tamaoki T. RT Involvement of an AFP1-binding site in cell-specific transcription of the RT pre-S1 region of the human hepatitis B virus surface antigen gene RL Nucleic Acids Res. 17:9833 (1989). RN [3] RX MEDLINE; 87004566. RA Shaul Y., Ben-Levy R., De-Medina T. RT High affinity binding site for nuclear factor I next to the hepatitis B RT virus S gene promotor RL EMBO J. 5:1967-1971 (1986). XX // AC G000164 XX ID HCMV$IEMP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IE XX DE immediate early major promoter XX OS hCMV, human cytomegalovirus OC viridae; ds-DNA enveloped viruses; herpesviridae; betaherpesvirinae XX BC 6.3.1.1 XX BS empty empty R01910; HCMV$IEMP_01; Binding factors: AP-1 . BS empty empty R01911; HCMV$IEMP_02; Binding factors: MBF1 . BS empty empty R01912; HCMV$IEMP_03; Binding factors: MBF2 , MBF3 BS . XX DR EMBL: X03922; HEHCMVP1. DR TRANSPATH: G000164. DR TRRD: 00016. XX RN [1] RX MEDLINE; 90067917. RA Shelbourn S. L., Kothari S. K., Sissons J. G. P., Sinclair J. H. RT Repression of human cytomegalovirus gene expression associated with a novel RT immediate early regulatory region binding factor RL Nucleic Acids Res. 17:9165-9171 (1989). XX // AC G000165 XX ID HCMV$IE1 XX DT 14.06.1995 (created); dbo. DT 10.12.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD IE-1 XX DE immediate early gene 1 XX OS hCMV, human cytomegalovirus OC viridae; ds-DNA enveloped viruses; herpesviridae; betaherpesvirinae XX BC 6.3.1.1 XX BS -1145 -773 R00787; HCMV$IE1_01. BS -1145 -773 R00788; HCMV$IE1_02. BS -781 -759 R00789; HCMV$IE1_03; Binding factors: NF-1 . BS -736 -710 R00790; HCMV$IE1_04; Binding factors: NF-1 . BS -688 -664 R00791; HCMV$IE1_05; Binding factors: NF-1 . BS -632 -604 R00792; HCMV$IE1_06; Binding factors: NF-1 . BS -602 -540 R00793; HCMV$IE1_07. BS -529 -508 R00794; HCMV$IE1_08. BS -498 -473 R00795; HCMV$IE1_09. BS -473 -439 R00796; HCMV$IE1_10. BS -447 -421 R00797; HCMV$IE1_11; Binding factors: EF-C , MDBP BS . BS -428 -411 R03378; HCMV$IE1_25. BS -419 -396 R00798; HCMV$IE1_12. BS -376 -353 R00799; HCMV$IE1_13; Binding factors: NF-1 . BS -335 -314 R00800; HCMV$IE1_14. BS -304 -281 R00801; HCMV$IE1_15. BS -270 0 R03380; HCMV$IE1_27. BS -267 -227 R00802; HCMV$IE1_16; Binding factors: NF-1 . BS -227 -214 R03424; HCMV$IE1_28; Binding factors: EF-C , MDBP BS . BS -215 -189 R00803; HCMV$IE1_17; Binding factors: NF-1 . BS -185 -14 R00804; HCMV$IE1_18. BS -165 0 R00805; HCMV$IE1_19; Binding factors: AP-1 . BS -165 0 R00806; HCMV$IE1_20; Binding factors: AP-1 , BS NF-kappaB . BS -140 0 R03377; HCMV$IE1_24. BS -120 0 R00807; HCMV$IE1_21; Binding factors: ATF , CRE-BP1 BS . BS -100 0 R03379; HCMV$IE1_26. BS -65 0 R00808; HCMV$IE1_22; Binding factors: NF-kappaB . BS 345 359 R00809; HCMV$IE1_23; Binding factors: NF-1 . XX DR EMBL: X17403; HEHCMVCG. DR TRANSPATH: G000165. XX RN [1] RX MEDLINE; 91319560. RA Chapman B. S., Thayer R. M., Vincent K. A., Haigwood N. L. RT Effect of intron A from human cytomegalovirus (Towne) immediate-early gene RT on heterologous expression in mammalian cells RL Nucleic Acids Res. 19:3979-3986 (1991). RN [2] RX MEDLINE; 91305121. RA Niller H. H., Hennighausen L. RT Formation of several specific nucleoprotein complexes on the human RT cytomegalovirus immediate early enhancer RL Nucleic Acids Res. 19:3715-3721 (1991). RN [3] RX MEDLINE; 91220738. RA Garcia A. D., Ostapchuk P., Hearing P. RT Methylation-dependent and -independent DNA binding of nuclear factor EF-C RL Virology 182:857-860 (1991). RN [4] RX MEDLINE; 91220740. RA Zhang X.-Y., Inamdar N. M., Supakar P. C., Wu K., Ehrlich K. C., Ehrlich M. RT Three MDBP sites in the immediate-early enhancer-promoter region of human RT cytomegalovirus RL Virology 182:865-869 (1991). RN [5] RX MEDLINE; 90205810. RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H. RT A cDNA for a human cyclic AMP response element-binding protein which is RT distinct from CREB and expressed preferentially in brain RL Mol. Cell. Biol. 10:1347-1357 (1990). RN [6] RX MEDLINE; 90101374. RA Ghazal P., Lubon H., Reynolds-Kohler C., Hennighausen L., Nelson J. A. RT Interactions between Cellular Regulatory Proteins and a Unique Region in RT the Human Cytomegalovirus Major Immediate-Early Promoter RL Virology 174:18-25 (1990). RN [7] RX MEDLINE; 90076147. RA Sambucetti L. C., Cherrington J. M., Wilkinson G. W. G., Mocarski E. S. RT NF-kappaB activation of the cytomegalovirus enhancer is mediated by a viral RT transactivator and by T cell stimulation RL EMBO J. 8:4251-4258 (1989). RN [8] RX MEDLINE; 89261742. RA Lubon H., Ghazal P., Hennighausen L., Reynolds-Kohler C., Lockshin C., RA Nelson J. RT Cell-Specific Activity of the Modulator Region in the Human Cytomegalovirus RT Major Immediate-Early Gene RL Mol. Cell. Biol. 9:1342-1345 (1989). RN [9] RX MEDLINE; 90067917. RA Shelbourn S. L., Kothari S. K., Sissons J. G. P., Sinclair J. H. RT Repression of human cytomegalovirus gene expression associated with a novel RT immediate early regulatory region binding factor RL Nucleic Acids Res. 17:9165-9171 (1989). RN [10] RX MEDLINE; 87231877. RA Ghazal P., Lubon H., Fleckenstein B., Hennighausen L. RT Binding of transcription factors and creation of a large nucleoprotein RT complex on the human cytomegalovirus enhancer RL Proc. Natl. Acad. Sci. USA 84:3658-3662 (1987). RN [11] RX MEDLINE; 86274639. RA Hennighausen L., Fleckenstein B. RT Nuclear factor 1 interacts with five DNA elements in the promoter region of RT the human cytomegalovirus major immediate early gene RL EMBO J. 5:1367-1371 (1986). XX // AC G000167 XX ID HIV1$HIV1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD HIV-1 XX DE human immunodeficiency virus type 1 XX OS HIV-1, human immunodeficiency virus type 1 OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; lentivirinae XX BC 6.2.1.4 XX BS -465 -156 R00694; HIV1$HIV1_01. BS -423 -416 R08143; HIV1$HIV1_29; Binding factors: GATA-3 . BS -378 -370 R08144; HIV1$HIV1_30; Binding factors: GATA-3 . BS -357 -316 R00695; HIV1$HIV1_02; Binding factors: AP-1 . BS -356 -320 R03406; HIV1$HIV1_21; Binding factors: COUP-TF1 . BS -344 -335 R08145; HIV1$HIV1_31; Binding factors: GATA-3 . BS -339 -317 R03405; HIV1$HIV1_20; Binding factors: COUP-TF1 . BS -320 -295 R00696; HIV1$HIV1_03. BS -294 -287 R08146; HIV1$HIV1_32; Binding factors: GATA-3 . BS -283 -255 R03641; HIV1$HIV1_23; Binding factors: FOXK1a , FOXN2 BS . BS -257 0 R03543; HIV1$HIV1_22; Binding factors: GR . BS -254 -216 R00697; HIV1$HIV1_04; Binding factors: NFAT-1 . BS -223 -195 R03642; HIV1$HIV1_24; Binding factors: FOXK1a , FOXN2 BS . BS -173 -159 R00698; HIV1$HIV1_05; Binding factors: C/EBPbeta . BS -172 -164 R08147; HIV1$HIV1_33; Binding factors: GATA-3 . BS -142 -121 R08638; HIV1$HIV1_36; Binding factors: LEF-1 . BS -126 -117 R08148; HIV1$HIV1_34; Binding factors: GATA-3 . BS -114 -106 R08140; HIV1$HIV1_28; Binding factors: C/EBPbeta . BS -107 -74 R00699; HIV1$HIV1_06; Binding factors: c-Rel , c-Rel BS , MBP-1 (1) , NF-kappaB , NF-kappaB , BS NF-kappaB1 , HIV-EP2 , AT-BP1 , AT-BP2 , BS NF-kappaB1 . BS -105 -96 R00700; HIV1$HIV1_07; Binding factors: NF-kappaB , BS NF-kappaB1 . BS -105 -71 R00702; HIV1$HIV1_09; Binding factors: NF-kappaB1 , BS BCL-6 . BS -103 -96 R00701; HIV1$HIV1_08; Binding factors: NF-kappaB . BS -100 -94 R01745; HIV1$HIV1_15; Binding factors: MBP-1 (1) . BS -92 -81 R00703; HIV1$HIV1_10; Binding factors: NF-kappaB . BS -86 -80 R01746; HIV1$HIV1_16; Binding factors: MBP-1 (1) . BS -82 -44 R00704; HIV1$HIV1_11; Binding factors: Sp1 , Vpr BS . BS -81 -39 R04754; HIV1$HIV1_26; Binding factors: HMBP . BS -77 -45 R04839; HIV1$HIV1_27; Binding factors: Sp1 , Sp3 BS , Sp3 . BS -42 -14 R00705; HIV1$HIV1_12; Binding factors: DBF4 , NC1 BS , TBP , TBP , TFIIA , TFIIB , TFIID BS , TMF , TFIIA-alpha/beta precursor (major) , BS TFIIA-alpha/beta precursor (minor) , TFIIA-gamma . BS -42 28 R00706; HIV1$HIV1_13; Binding factors: UBP-1 . BS -30 4 R09720; HIV1$HIV1_37; Binding factors: HLTF . BS -28 -7 R03168; HIV1$HIV1_18; Binding factors: LBP-1 . BS -13 52 R00707; HIV1$HIV1_14; Binding factors: TAR factor . BS -6 27 R03169; HIV1$HIV1_19; Binding factors: LBP-1 . BS -6 20 R09721; HIV1$HIV1_38; Binding factors: HLTF . BS 115 315 R02392; HIV1$HIV1_17; Binding factors: c-Myb . BS 455 511 R02421; HIV1$HIV1_25; Binding factors: tat . XX DR EMBL: L28869; HIV2A5LTR. DR EMBL: M15653; HIVBH101. DR EMBL: M15654; HIVBH102. DR EMBL: K02013; HIVBRUCG. DR EMBL: M38431; HIVNY5CG. DR EMBL: K02083; HIVPV22. DR EMBL: L07422; HIVSF2B13. DR EMBL: M38427; HIVSF33. DR EMBL: M21098; REHIVBRV. DR EMBL: K03455; REHIVHXB. DR TRANSPATH: G000167. DR TRANSCOMPEL: C00055. DR TRANSCOMPEL: C00233. DR TRANSCOMPEL: C00235. DR TRANSCOMPEL: C00257. DR TRANSCOMPEL: C00350. DR TRANSCOMPEL: C00351. DR TRRD: 00184. XX RN [1] RX MEDLINE; 97281682. RA Baron B. W., Desai M., Baber L. J., Paras L., Zhang Q., Sadhu A., Duguay RA S., Nucifora G., McKeithan T. W., Zeleznik-Le N. RT BCL6 can repress transsription from the human immunodeficiency virus typeI RT promoter/enhancer region RL Genes Chromosomes Cancer 19:14-21 (1997). RN [2] RX MEDLINE; 96029641. RA Wang L., Mukherjee S., Jia F., Narayan O., Zhao L.-J. RT Interaction of virion protein Vpr of human immunodeficiency virus type 1 RT with cellular transcription factor Sp1 and trans-activation of viral long RT terminal repeat RL J. Biol. Chem. 270:25564-25569 (1995). RN [3] RX MEDLINE; 95385995. RA Sheridan P. L., Sheline C. T., Cannon K., Voz M. L., Pazin M. J., Kadonaga RA J. T., Jones K. A. RT Activation of the HIV-1 enhancer by the LEF-1 HMG protein on RT nucleosome-assembled DNA in vitro RL Genes Dev. 9:2090-2104 (1995). RN [4] RX MEDLINE; 95181452. RA Sheridan P. L., Schorpp M., Voz M. L., Jones K. A. RT Cloning of an SNF2/SWI2-related protein that binds speficially to the SPH RT motifs of the SV40 enhancer and to the HIV-1 promoter RL J. Biol. Chem. 270:4575-4587 (1995). RN [5] RX MEDLINE; 95098605. RA Majello B., de Luca P., Hagen G., Suske G., Lania L. RT Different members of the Sp1 multigene family exert opposite RT transcriptional regulation of the long terminal repeat of HIV-1 RL Nucleic Acids Res. 22:4914-4921 (1994). RN [6] RX MEDLINE; 95074074. RA Li Y., Mak G., Franza jr B. R. RT In vitro study of functional involvement of Sp1, NF-kappa B/Rel, and AP-1 RT in phorbol 12-myristate 13-acetate-mediated HIV-1 long terminal repeat RT activation RL J. Biol. Chem. 269:30616-30619 (1994). RN [7] RX MEDLINE; 93216765. RA Borellini F., Glazer R. I. RT Induction of Sp1-p53 DNA-binding heterocomplexes during RT granulocyte/macrophage colony-stimulating factor-dependent proliferation in RT human erythroleukemia cell line TF-1 RL J. Biol. Chem. 268:7923-7928 (1993). RN [8] RX MEDLINE; 94112005. RA Joel P., Shao W., Pratt K. RT A Nuclear protein with enhanced binding to methylated Sp1 sites in the AIDS RT virus promoter RL Nucleic Acids Res. 21:5786-5793 (1993). RN [9] RX MEDLINE; 93348260. RA Tesmer V. M., Rajadhyaksha A., Babin J., Bina M. RT NF-IL6-mediated transcriptional activation of the long terminal repeat of RT the human immunodeficiency virus type 1 RL Proc. Natl. Acad. Sci. USA 90:7298-7302 (1993). RN [10] RX MEDLINE; 93324366. RA Yang Z., Engel J. D. RT Human T cell transcription factor GATA-3 stimulates HIV-1 expression RL Nucleic Acids Res. 21:2831-2836 (1993). RN [11] RX MEDLINE; 92085433. RA Ghosh D. RT Glucocorticoid receptor-binding site in the human immunodeficiency virus RT long terminal repeat RL J. Virol. 66:586-590 (1992). RN [12] RX MEDLINE; 93028466. RA Garcia J. A., Ou S.-H. I., Wu F., Lusis A. J., Sparkes R. S., Gaynor R. B. RT Cloning and chromosomal mapping of a human immunodeficiency virus 1 TATA RT element modulatory factor RL Proc. Natl. Acad. Sci. USA 89:9372-9376 (1992). RN [13] RX MEDLINE; 92347334. RA Meyer M., Caselmann W. H., Schlueter V., Schreck R., Hofschneider P. H., RA Baeuerle P. A. RT Hepatitis B virus transactivator MHBst; Activation of NF-kappaB, selective RT inhibition by antioxidants and integral membrane localization RL EMBO J. 11:2991- 3001 (1992). RN [14] RX MEDLINE; 92347862. RA Li C., Lusis A. J., Sparkes R., Tran S. M., Gaynor R. RT Characterization and chromosomal mapping of the gene encoding the cellular RT DNA binding protein HTLF RL Genomics 13:658-664 (1992). RN [15] RX MEDLINE; 92103689. RA Lee D. K., Horikoshi M., Roeder R. G. RT Interaction of TFIID in the minor groove of the TATA element RL Cell 67:1241-1250 (1991). RN [16] RX MEDLINE; 91340726. RA Borellini F., He Y. F., Aquino A., Yu G., Josephs S. F., Glazer R. I. RT Increased DNA binding and transcriptional activity associated with RT transcription factor Sp1 in K562 cells transfected with the RT myeloid-specific c-fes tyrosine kinase gene RL J. Biol. Chem. 266:15850-15854 (1991). RN [17] RX MEDLINE; 91217105. RA Nomura N., Zhao M.-J., Nagase T., Maekawa T., Ishizaki R., Tabata S., Ishii RA S. RT HIV-EP2, a new member of the gene family encoding the human RT immunodeficiency virus type 1 enhancer-binding protein RL J. Biol. Chem. 266:8590-8594 (1991). RN [18] RX MEDLINE; 91237798. RA Cooney A. J., Tsai S. Y., O'Malley B. W., Tsai M.-J. RT Chicken ovalbumin upstream promoter transcription factor binds to a RT negative regulatory region in the human immunodeficiency virus type 1 long RT terminal repeat RL J. Virol. 65:2853-2860 (1991). RN [19] RX MEDLINE; 92017769. RA Baldwin jr A. S., Azizkhan J. C., Jensen D. E., Beg A. A., Coodly L. R. RT Induction of NF-kappaB DNA-binding activity during G0-to-G1 transition in RT mouse fibroblasts RL Mol. Cell. Biol. 11:4943-4951 (1991). RN [20] RX MEDLINE; 91218850. RA Bachelerie F., Alcami J., Arenzana-Seisdedos F., Virelizier J.-L. RT HIV enhancer activity perpetuated by NF-kappaB induction on infection of RT monocytes RL Nature 350:709-712 (1991). RN [21] RX MEDLINE; 91204058. RA Riviere Y., Blank V., Kourilsky P., Israel A. RT Processing of the precursor of NF-kappaB by the HIV-1 protease during acute RT infection RL Nature 350:625-626 (1991). RN [22] RX MEDLINE; 91187610. RA Mitchelmore C., Traboni C., Cortese R. RT Isolation of two cDNAs encoding zinc finger proteins which bind to the RT alpha1-antitrypsin promoter and to the major histocompatibility complex RT class I enhancer RL Nucleic Acids Res. 19:141-147 (1991). RN [23] RX MEDLINE; 92066454. RA Yamamoto K., Mori S., Okamoto T., Shimotohno K., Kyogoku Y. RT Identification of transcriptional suppressor proteins that bind to the RT negative regulatory element of the human immunodeficiency virus type 1 RL Nucleic Acids Res. 19:6107-6112 (1991). RN [24] RX MEDLINE; 91219442. RA Inoue J.-I., Kerr L. D., Ransone L. J., Bengal E., Hunter T., Verma I. M. RT c-rel activates but v-rel suppresses transcription from kappaB sites RL Proc. Natl. Acad. Sci. USA 88:3715-3719 (1991). RN [25] RX MEDLINE; 91352065. RA Li C., Lai C., Sigman D. S., Gaynor R. B. RT Cloning of a cellular factor, interleukin binding factor, that binds to RT NFAT-like motifs in the human immunodeficiency virus long terminal repeat RL Proc. Natl. Acad. Sci. USA 88:7739-7743 (1991). RN [26] RX MEDLINE; 91173307. RA Kato H., Horikoshi M., Roeder R. G. RT Repression of HIV-1 transcription by a cellular protein RL Science 251:1476-1479 (1991). RN [27] RX MEDLINE; 92052106. RA Raziuddin, Mikovits J. A., Calvert I., Ghosh S., Kung H.-F. RT Negative regulation of human immunodeficiency virus type 1 expression in RT monocytes: Role of the 65-kDa plus 50-kDa NF-kappaB dimer RL Proc. Natl. Acad. Sci. USA 88:9426-9430 (1991). RN [28] RX MEDLINE; 90243720. RA Meichle A., Schuetze S., Hensel G., Brunsing D., Kroenke M. RT Protein Kinase-C-independent Activation of Nuclear Factor kB by Tumor RT Necrosis Factor RL J. Biol. Chem. 265:8339-8343 (1990). RN [29] RX MEDLINE; 90156535. RA Clark L., Matthews J. R., Hay R. T. RT Interaction of enhancer-binding protein EBP1 (NF-kappaB) with the human RT immunodeficiency virus type 1 enhancer RL J. Virol. 64:1335-1344 (1990). RN [30] RX MEDLINE; 90205817. RA Baldwin jr A. S., LeClair K. P., Singh H., Sharp P. A. RT A large protein containing zinc finger domains binds to related sequence RT elements in the enhancers of the class I major histocompatibility complex RT and kappa immunoglobulin genes RL Mol. Cell. Biol. 10:1406-1414 (1990). RN [31] RX MEDLINE; 91043047. RA Bours V., Villalobos J., Burd P. R., Kelly K., Siebenlist U. RT Cloning of a mitogen-inducible gene encoding a kappaB DNA-binding protein RT with homology to the rel oncogene and to cell-cycle motifs RL Nature 348:76-80 (1990). RN [32] RX MEDLINE; 91045897. RA Hazan U., Thomas D., Alcami J., Bachelerie F., Israel N., Yssel H., RA Virelizier J.-L., Arenzana-Seisdedos F. RT Stimulation of a human T-cell clone with anti-CD3 or tumor necrosis factor RT induces NF-kappaB translocation but not human immunodeficiency virus type 1 RT enhancer-dependent transcription RL Proc. Natl. Acad. Sci. USA 87:7861-7865 (1990). RN [33] RX MEDLINE; 91045943. RA Dasgupta P., Saikumar P., Reddy C. D., Reddy E. P. RT Myb protein binds to human immunodeficiency virus 1 long terminal repeat RT (LTR) sequences and transactivates LTR-mediated transcription RL Proc. Natl. Acad. Sci. USA 87:8090-8094 (1990). RN [34] RX MEDLINE; 91062404. RA Cordingley M. G., LaFemina R. L., Callahan P. L., Condra J. H., Sardana V. RA V., Graham D. J., Nguyen T. M., LeGrow K., Gotlib L., Schlabach A. J., RA Colonno R. J. RT Sequence-specific interaction of Tat protein and Tat peptides with the RT transactivation-responsive sequence element of human immunodeficiency virus RT type 1 in vitro RL Proc. Natl. Acad. Sci. USA 87:8985-8989 (1990). RN [35] RX MEDLINE; 91088627. RA Staal F. J. T., Roederer M., Herzenberg L. A. RT Intracellular thiols regulate activation of nuclear factor kappaB and RT transcription of human immunodeficiency virus RL Proc. Natl. Acad. Sci. USA 87:9943-9947 (1990). RN [36] RX MEDLINE; 89251608. RA Garcia J. A., Harrich D., Soultanakis E., Wu F., Mitsuyasu R., Gaynor R. B. RT Human immunodeficiency virus type 1 LTR TATA and TAR region sequences RT required for transcriptional regulation RL EMBO J. 8:765-778 (1989). RN [37] RX MEDLINE; 90059887. RA Ensoli B., Lusso P., Schachter F., Josephs S. F., Rappaport J., Negro F., RA Gallo R. C., Wong-Staal F. RT Human herpes virus-6 increases HIV-1 expression in co-infected T cells via RT nuclear factors binding to the HIV-1 enhancer RL EMBO J. 8:3019-3027 (1989). RN [38] RX MEDLINE; 90185221. RA Patarca R., Singh R. P., Durfee T., Freeman G., Blattner F. R., Cantor H. RT Definition of T-cell specific DNA-binding factors that interact with a RT 3'-silencer in the CD4+ T-cell gene Rpt-1 RL Gene 85:461-469 (1989). RN [39] RX MEDLINE; 89123381. RA Maekawa T., Itoh F., Okamoto T., Kurimoto M., Imamoto F., Ishii S. RT Identification and Purification of the Enhancer-binding Factor of Human RT Immunodeficiency Virus-1 RL J. Biol. Chem. 264:2826-2831 (1989). RN [40] RX MEDLINE; 89359241. RA Maekawa T., Sakura H., Sudo T., Ishii S. RT Putative metal finger structure of the human immunodeficiency virus type 1 RT enhancer binding protein HIV-EP1 RL J. Biol. Chem. 264:14591-14593 (1989). RN [41] RX MEDLINE; 90097934. RA Stein B., Rahmsdorf H. J., Steffen A., Litfin M., Herrlich P. RT UV-Induced DNA Damage Is an Intermediate Step in UV-Induced Expression of RT Human Immunodeficiency Virus Type 1 Collagenase, c-fos and Metallothionein RL Mol. Cell. Biol. 9:5169-5181 (1989). RN [42] RX MEDLINE; 90097879. RA Ivanov V., Stein B., Baumann I., Dobbelaere D. A. E., Herrlich P., Williams RA R. O. RT Infection with the Intracellular Protozoan Parasite Theileria parva Induces RT Constitutively High Levels of NF-kB in Bovine T Lymphocytes RL Mol. Cell. Biol. 9:4677-4686 (1989). RN [43] RX MEDLINE; 89128426. RA Clark L., Hay R. T. RT Sequence requirements for specific interaction of an enhancer binding RT protein (EBP1) with DNA RL Nucleic Acids Res. 17:499-516 (1989). RN [44] RX MEDLINE; 89184621. RA Osborn L., Kunkel S., Nabel G. J. RT Tumor necrosis factor alpha and interleukin 1 stimulate the human RT immunodeficiency virus enhancer by activation of the nuclear factor kB RL Proc. Natl. Acad. Sci. USA 86:2336-2340 (1989). RN [45] RX MEDLINE; 89345587. RA Duh E. J., Maury W. J., Folks T. M., Fauci A. S., Rabson A. B. RT Tumor necrosis factor alpha activates human immunodeficiency virus type 1 RT through induction of nuclear factor binding to the NF-kB sites in the long RT terminal repeat RL Proc. Natl. Acad. Sci. USA 86:5974-5978 (1989). RN [46] RX MEDLINE; 89242103. RA Hoyos B., Ballard D. W., Boehnlein E., Siekevitz M., Greene W. C. RT Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human RT Interleukin-2 Gene Expression RL Science 244:457-460 (1989). RN [47] RX MEDLINE; 88223375. RA Boehnlein E., Lowenthal J. W., Siekevitz M., Ballard D. W., Franza B. R., RA Greene W. C. RT The Same Inducible Nuclear Protein Regulates Mitogen Activation of Both the RT Interleukin-2 Receptor-Alpha Gene and Type 1 HIV RL Cell 53:827-836 (1988). RN [48] RX MEDLINE; 88329000. RA Wu F. K., Garcia J. A., Harrich D., Gaynor R. B. RT Purification of the human immunodeficiency virus type 1 enhancer and TAR RT binding proteins EBP-1 and UBP-1 RL EMBO J. 7:2117-2129 (1988). RN [49] RX MEDLINE; 89071707. RA Gaynor R. B., Kuwabara M. D., Wu F. K., Garcia J. A., Harrich D., Briskin RA M., Wall R., Sigman D. S. RT Repeated B motifs in the human immunodeficiency virus type I long terminal RT repeat enhancer region do not exhibit cooperative factor binding RL Proc. Natl. Acad. Sci. USA 85:9406-9410 (1988). RN [50] RX MEDLINE; 88263016. RA Kawakami K., Scheidereit C., Roeder R. G. RT Identification and purification of a human immunoglobulin-enhancer-binding RT protein (NF-kappaB) that activates transcription from a human RT immunodeficiency virus type 1 promoter in vitro RL Proc. Natl. Acad. Sci. USA 85:4700-4704 (1988). RN [51] RX MEDLINE; 88145673. RA Franza jr B. R., Rauscher III F. J., Josephs S. F., Curran T. RT The Fos-complex and Fos-related antigens recognize sequence elements that RT contain AP-2 binding sites RL Science 239:1150-1153 (1988). RN [52] RX MEDLINE; 88264423. RA Shaw J.-P., Utz P. J., Durand D. B., Toole J. J., Emmel E. A., Crabtree G. RA R. RT Identification of a Putative Regulator of Early T Cell Activation Genes RL Science 241:202-205 (1988). RN [53] RX MEDLINE; 88111565. RA Garcia J. A., Wu F. K., Mitsuyasu R., Gaynor R. B. RT Interaction of cellular proteins involved in the transcriptional regulation RT of the human immunodeficiency virus RL EMBO J. 6:3761-3770 (1987). RN [54] RX MEDLINE; 88166651. RA Dinter H., Chiu R., Imagawa M., Karin M., Jones K. A. RT in vitro activation of the HIV-1 enhancer in extracts from cells treated RT with a phorbol ester tumor promoter RL EMBO J. 6:4067-4071 (1987). RN [55] RX MEDLINE; 88065861. RA Franza jr B. R., Josephs S. F., Gilman M. Z., Ryan W., Clarkson B. RT Characterization of cellular proteins recognizing the HIV enhancer using a RT microscale DNA-affinity precipitation assay RL Nature 330:391-395 (1987). RN [56] RX MEDLINE; 86179897. RA Jones K. A., Kadonaga J. T., Luciw P. A., Tjian R. RT Activation of the AIDS retrovirus promoter by the cellular transcription RT factor, Sp1 RL Science 232:755-759 (1986). XX // AC G000168 XX ID HIV2$HIV2 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD HIV-2 XX DE human immunodeficiency virus type 2 XX OS HIV-2, human immunodeficiency virus type 2 OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; lentivirinae XX BC 6.2.1.4 XX BS 25 0 R02631; HIV2$HIV2_01; Binding factors: CTF . BS 34 80 R02632; HIV2$HIV2_02; Binding factors: LBP-1 . BS 80 125 R02633; HIV2$HIV2_03; Binding factors: LBP-1 . BS 160 0 R02634; HIV2$HIV2_04; Binding factors: CTF . XX DR TRANSPATH: G000168. DR TRANSCOMPEL: C00234. XX RN [1] RX MEDLINE; 89252806. RA Toohey M. G., Jones K. A. RT In vitro formation of short RNA polymerase II transcripts that terminate RT within the HIV-1 and HIV-2 promoter-proximal downstream regions RL Genes Dev. 3:265-282 (1989). XX // AC G000170 XX ID HPV$HPV11 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD HPV-11 XX DE human papilloma virus type 11 XX OS HPV-11, human papilloma virus type 11 OC viridae; ds-DNA nonenveloped viruses; papovaviridae; papillomavirus XX BC 6.3.4 XX BS 7658 7674 R00729; HPV$HPV11_01; Binding factors: NF-1 . BS 7688 7706 R00730; HPV$HPV11_02; Binding factors: NF-1 . BS 7774 7790 R00731; HPV$HPV11_03; Binding factors: NF-1 . BS 7804 7820 R00732; HPV$HPV11_04; Binding factors: NF-1 . XX DR EMBL: M14119; PAPPPH11. DR TRANSPATH: G000170. XX RN [1] RX MEDLINE; 89263791. RA Gloss B., Yeo-Gloss M., Meisterernst M., Rogge L., Winnacker E. L., Bernard RA H.-U. RT Clusters of nuclear factor I binding sites identify enhancers of several RT papillomaviruses but lone are not sufficient for enhancer function RL Nucleic Acids Res. 17:3519-3533 (1989). XX // AC G000171 XX ID HPV$HPV16 XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD HPV-16 XX DE human papilloma virus type 16 E6 promoter XX OS HPV-16, human papilloma virus type 16 OC viridae; ds-DNA nonenveloped viruses; papovaviridae; papillomavirus XX BC 6.3.4 XX BS empty empty R03429; HPV$HPV16_13. BS 30 39 R02922; HPV$HPV16_12; Binding factors: Sp1 . BS 40 53 R04678; HPV$HPV16_14; Binding factors: E2 . BS 7472 7486 R00733; HPV$HPV16_01; Binding factors: NF-1 . BS 7543 7559 R00734; HPV$HPV16_02; Binding factors: NF-1 . BS 7576 7592 R00735; HPV$HPV16_03; Binding factors: NF-1 . BS 7630 7638 R00736; HPV$HPV16_04; Binding factors: AP-1 . BS 7637 7658 R00737; HPV$HPV16_05; Binding factors: GR . BS 7664 7680 R00738; HPV$HPV16_06; Binding factors: NF-1 . BS 7710 7726 R00739; HPV$HPV16_07; Binding factors: NF-1 . BS 7741 7757 R00740; HPV$HPV16_08; Binding factors: NF-1 . BS 7755 7771 R00741; HPV$HPV16_09; Binding factors: NF-1 . BS 7809 7817 R00742; HPV$HPV16_10; Binding factors: AP-1 . XX DR EMBL: K02718; PA16. DR TRANSPATH: G000171. DR SMARTDB: SM0000158. DR SMARTDB: SM0000159. DR SMARTDB: SM0000160. DR SMARTDB: SM0000161. DR SMARTDB: SM0000162. DR TRRD: 00032. XX RN [1] RX MEDLINE; 92158609. RA Tan S. H., Gloss B., Bernard H. U. RT During negative regulation of the human papillomavirus-16 E6 promoter, the RT viral E2 protein can displace Sp1 from a proximal promoter element RL Nucleic Acids Res. 20:251-256 (1992). RN [2] RX MEDLINE; 91360357. RA Dent C. L., McIndoe G. A. J., Latchman D. S. RT The constitutively expressed octamer binding protein OTF-1 and a novel RT octamer binding protein expressed specifically in cervical cells bind to an RT octamer-related sequence in the human papillomavirus 16 enhancer RL Nucleic Acids Res. 19:4531-4535 (1991). RN [3] RX MEDLINE; 91012803. RA Gloss B., Bernard H.-U. RT The E6/E7 promoter of human papillomavirus type 16 is activated in the RT absence of E2 proteins by a sequence-aberrant Sp1 distal element RL J. Virol. 64:5577-5584 (1990). RN [4] RX MEDLINE; 90192147. RA Chan W.-K., Chong T., Bernard H.-U., Klock G. RT Transcription of the transforming genes of the oncogenic human RT papillomavirus-16 is stimulated by tumor promoters through AP1 binding sites RL Nucleic Acids Res. 18:763-769 (1990). RN [5] RX MEDLINE; 89263791. RA Gloss B., Yeo-Gloss M., Meisterernst M., Rogge L., Winnacker E. L., Bernard RA H.-U. RT Clusters of nuclear factor I binding sites identify enhancers of several RT papillomaviruses but lone are not sufficient for enhancer function RL Nucleic Acids Res. 17:3519-3533 (1989). RN [6] RX MEDLINE; 88111562. RA Gloss B., Bernard H. U., Seedorf K., Klock G. RT The upstream regulatory region of the human papilloma virus-16 contains an RT E2 protein-independent enhancer which is specific for cervical carcinoma RT cells and regulated by glucocorticoid hormones RL EMBO J. 6:3735-3743 (1987). XX // AC G000172 XX ID HPV$HPV18 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD HPV-18 XX DE human papilloma virus type 18 XX OS HPV-18, human papilloma virus type 18 OC viridae; ds-DNA nonenveloped viruses; papovaviridae; papillomavirus XX BC 6.3.4 XX BS empty empty R03701; HPV$HPV18_06; Binding factors: E2 , TBP BS . BS 41 68 R00743; HPV$HPV18_07; Binding factors: E2 . BS 7512 7528 R00744; HPV$HPV18_01; Binding factors: NF-1 . BS 7568 7586 R00745; HPV$HPV18_02; Binding factors: NF-1 . BS 7606 7619 R03489; HPV$HPV18_04; Binding factors: AP-1 . BS 7647 7669 R03490; HPV$HPV18_05; Binding factors: KRF-1 . BS 7730 7736 R00746; HPV$HPV18_03; Binding factors: NF-1 . XX DR EMBL: X05015; PAPHPV18. DR TRANSPATH: G000172. XX RN [1] RX MEDLINE; 91357480. RA Dostatni N., Lambert P. F., Sousa R., Ham J., Howley P. M., Yaniv M. RT The functional BPV-1 E2 trans-activating protein can act as a repressor by RT preventing formation of the initiation complex RL Genes Dev. 5:1657-1671 (1991). RN [2] RX MEDLINE; 92020998. RA Mack D. H., Laimins L. A. RT A keratinocyte-specific transcription factor, KRF-1, interacts with AP-1 to RT activate expression of human papillomavirus type 18 in squamous epithelial RT cells RL Proc. Natl. Acad. Sci. USA 88:9102-9106 (1991). RN [3] RX MEDLINE; 89211890. RA Lambert P. F., Dostatni N., McBride A. A., Yaniv M., Howley P. M., RA Arcangioli B. RT Functional analysis of the papilloma virus E2 trans-activator in RT Saccharomyces cerevisiae RL Genes Dev. 3:38-48 (1989). RN [4] RX MEDLINE; 89263791. RA Gloss B., Yeo-Gloss M., Meisterernst M., Rogge L., Winnacker E. L., Bernard RA H.-U. RT Clusters of nuclear factor I binding sites identify enhancers of several RT papillomaviruses but lone are not sufficient for enhancer function RL Nucleic Acids Res. 17:3519-3533 (1989). RN [5] RX MEDLINE; 89091128. RA Dostatni N., Thierry F., Yaniv M. RT A dimer of BPV-1 E2 containing a protease resistant core interacts with its RT DNA target RL EMBO J. 7:3807-3816 (1988). XX // AC G000173 XX ID HPV$HPV8 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD HPV-8 XX DE human papilloma virus type 8 XX OS HPV-8, human papilloma virus type 8 OC viridae; ds-DNA nonenveloped viruses; papovaviridae; papillomavirus XX BC 6.3.4 XX BS 7510 7526 R00724; HPV$HPV8_01; Binding factors: NF-1 . BS 7532 7548 R00725; HPV$HPV8_02; Binding factors: NF-1 . BS 7579 7595 R00726; HPV$HPV8_03; Binding factors: NF-1 . BS 7599 7615 R00727; HPV$HPV8_04; Binding factors: NF-1 . BS 7620 7638 R00728; HPV$HPV8_05; Binding factors: NF-1 . XX DR EMBL: M12737; PAPPPH8C. DR TRANSPATH: G000173. XX RN [1] RX MEDLINE; 89263791. RA Gloss B., Yeo-Gloss M., Meisterernst M., Rogge L., Winnacker E. L., Bernard RA H.-U. RT Clusters of nuclear factor I binding sites identify enhancers of several RT papillomaviruses but lone are not sufficient for enhancer function RL Nucleic Acids Res. 17:3519-3533 (1989). XX // AC G000174 XX ID HS$4F2H XX DT 14.06.1995 (created); dbo. DT 12.11.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD 4F2HC XX DE 4F2 heavy chain XX SY 4T2HC; 4F2; CD98; MDU1; NACAE; MDV1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11q12-q22 XX BC 6.1.6 XX BS empty empty R00005; HS$4F2H_01; Binding factors: NF-4FA . BS empty empty R00006; HS$4F2H_02; Binding factors: NF-4FC . BS empty empty R00007; HS$4F2H_03; Binding factors: c-Jun . BS empty empty R00008; HS$4F2H_04; Binding factors: NF-4FB . XX DR EMBL: M21898; HS4F2HG1. DR TRANSPATH: G000174. DR TRRD: 00002. DR LOCUSLINK: 6520. DR OMIM: 158070. DR REFSEQ: NM_002394. XX RN [1] RX MEDLINE; 89343976. RA Karpinski B. A., Yang L.-H., Cacheris P., Morle G. D., Leiden J. M. RT The First Intron of the 4F2 Heavy-Chain Gene Contains a Transcriptional RT Enhancer Element That Binds Multiple Nuclear Proteins RL Mol. Cell. Biol. 9:2588-2597 (1989). XX // AC G000175 XX ID HS$5LOX XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD LOG5 XX DE 5-lipoxygenase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 10q11.2 XX BC 6.1.4.6 XX BS -212 -88 R02845; HS$5LOX_01. XX DR BRENDA: 1.13.11.34; Human. DR LOCUSLINK: 240. DR OMIM: 152390. DR REFSEQ: NM_000698. XX RN [1] RX MEDLINE; 91067649. RA Hoshiko S., Radmark O., Samuelsson B. RT Characterization of the human 5-lipoxygenase gene promoter RL Proc. Natl. Acad. Sci. USA 87:9073-9077 (1990). XX // AC G000176 XX ID HS$IFI616 XX DT 14.06.1995 (created); dbo. DT 12.11.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD IFI-6-16 XX DE interferon-induced gene 6-16 XX SY IFI616. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1 XX BC 6.1.7.2 XX BS -127 -89 R00001; HS$IFI616_01; Binding factors: ISGF-3 . BS -113 -96 R00002; HS$IFI616_02; Binding factors: ICSBP . XX DR EMBL: Y00828; HSIFNIN6. DR TRANSPATH: G000176. DR TRRD: 00270. DR LOCUSLINK: 2537. DR OMIM: 147572. DR REFSEQ: NM_002038. XX RN [1] RX MEDLINE; 91187669. RA Roy Ch., Lebleu B. RT DNA protein interactions at the interferon-responsive promoter elements: RT potential for a H-DNA conformation RL Nucleic Acids Res. 19:517 (1991). RN [2] RX MEDLINE; 91056171. RA Seong D. C., Sims S., Johnson E., Howard O. M. Z., Reiter B., Hester J., RA Talpaz M., Kantarjian H., Deisseroth A. RT A phosphatase activity present in peripheral blood myeloid cells of chromic RT myelogenous leukemia patients but not normal individuals alters nuclear RT protein binding to transcriptional enhancers of interferon-inducible genes RL J. Clin. Invest. 86:1664-1670 (1990). RN [3] RX MEDLINE; 91067441. RA Imam A. M. A., Ackrill A. M., Dale T. C., Kerr I. M., Stark G. R. RT Transcription factors induced by interferons alpha and gamma RL Nucleic Acids Res. 18:6573-6580 (1990). RN [4] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [5] RX MEDLINE; 89251615. RA Dale T. C., Rosen J. M., Guille M. J., Lewin A. R., Porter A. G. C., Kerr RA I. M., Stark G. R. RT Overlapping sites for constitutive and induced DNA binding factors involved RT in interferon-stimulated transcription RL EMBO J. 8:831-839 (1989). RN [6] RX MEDLINE; 89145211. RA Dale T. C., Ali Imam A. M., Kerr I. M., Stark G. R. RT Rapid activation by interferon alpha of a latent DNA-binding protein RT present in the cytoplasm of untreated cells RL Proc. Natl. Acad. Sci. USA 86:1203-1207 (1989). RN [7] RX MEDLINE; 88196095. RA Porter A. C. G., Chernajowski Y., Dale T. C., Gilbert C. S., Stark G. R., RA Kerr I. M. RT Interferon response element of the human gene 6-16 RL EMBO J. 7:85-92 (1988). XX // AC G000177 XX ID HS$7SK XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD 7S K RNA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BS -74 -44 R04275; HS$7SK_01; Binding factors: PTF . XX DR TRANSPATH: G000177. XX RN [1] RX MEDLINE; 92318942. RA Murphy S., Yoon J.-B., Gerster T., Roeder R. G. RT Oct-1 and Oct-2 potentiate functional interactions of a transcription RT factor with the proximal sequence element of small nuclear RNA genes RL Mol. Cell. Biol. 12:3247-3261 (1992). XX // AC G000178 XX ID HS$7SL XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD 7S L RNA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BS -46 0 R02812; HS$7SL_01; Binding factors: ATF . XX DR EMBL: X04249; HS7SLG. DR TRANSPATH: G000178. XX RN [1] RX MEDLINE; 91088246. RA Bredow S., Suerig D., Mueller J., Kleinert H., Benecke B.-J. RT Activating-transcription-factor (ATF) regulates human 7S L RNA RT transcription by RNA polymerase III in vivo and in vitro RL Nucleic Acids Res. 18:6779 (1990). XX // AC G000179 XX ID HS$927 XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD 9-27 XX DE interferon-induced RNA binding protein 9-27 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.2.3 XX BS -185 -147 R00003; HS$927_01; Binding factors: ISGF-3 , G factor BS , M factor . XX DR EMBL: J04164; HS927A. DR TRANSPATH: G000179. DR TRRD: 00271. DR LOCUSLINK: 8519. DR OMIM: 604456. DR REFSEQ: NM_003641. XX RN [1] RX MEDLINE; 91360336. RA Ackrill A. M., Foster G. R., Laxton C. D., Flavell D. M., Stark G. R., Kerr RA I. M. RT Inhibition of the cellular response to interferons by products of the RT adenovirus type 5 E1A oncogene RL Nucleic Acids Res. 19:4387-4393 (1991). RN [2] RX MEDLINE; 91187896. RA Foster G. R., Ackrill A. M., Goldin R. D., Kerr I. M., Thomas H. C., Stark RA G. R. RT Expression of the terminal protein region of hepatitis B virus inhibits RT cellular responses to interferons alpha and gamma and double-stranded RNA RL Proc. Natl. Acad. Sci. USA 88:2888-2892 (1991). RN [3] RX MEDLINE; 91056171. RA Seong D. C., Sims S., Johnson E., Howard O. M. Z., Reiter B., Hester J., RA Talpaz M., Kantarjian H., Deisseroth A. RT A phosphatase activity present in peripheral blood myeloid cells of chromic RT myelogenous leukemia patients but not normal individuals alters nuclear RT protein binding to transcriptional enhancers of interferon-inducible genes RL J. Clin. Invest. 86:1664-1670 (1990). RN [4] RX MEDLINE; 91067441. RA Imam A. M. A., Ackrill A. M., Dale T. C., Kerr I. M., Stark G. R. RT Transcription factors induced by interferons alpha and gamma RL Nucleic Acids Res. 18:6573-6580 (1990). RN [5] RX MEDLINE; 89145211. RA Dale T. C., Ali Imam A. M., Kerr I. M., Stark G. R. RT Rapid activation by interferon alpha of a latent DNA-binding protein RT present in the cytoplasm of untreated cells RL Proc. Natl. Acad. Sci. USA 86:1203-1207 (1989). XX // AC G000180 XX ID HS$APP XX DT 14.06.1995 (created); dbo. DT 28.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD APP XX DE amyloid beta (A4) precursor protein XX SY AD1; Alzheimer's disease amyloid A4 protein precursor; beta-amyloid protein SY precursor; protease nexin-II; AAA. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 21q21.2 XX BC 6.1.3.4 XX BS -200 -100 R00010; HS$A4_01. BS -55 -36 R04408; HS$A4_02; Binding factors: USF1 , USF-1 BS , USF2 , USF2 , USF2b . XX DR EMBL: M34862; HSAMYB01. DR EMBL: M24546; HSAPPB01. DR EMBL: X12751; HSPADP. DR TRANSPATH: G000180. DR LOCUSLINK: 351. DR OMIM: 104760. DR REFSEQ: NM_000484. XX RN [1] RX MEDLINE; 95380291. RA Vostrov A. A., Quitschke W. W., Vidal F., Schwarzman A. L., Goldgaber D. RT USF binds to the APBalpha sequence in the promote of the amyloid RT beta-protein precursor gene RL Nucleic Acids Res. 23:2734-2741 (1995). RN [2] RX MEDLINE; 89030646. RA Salbaum J. M., Weidemann A., Lemaire H.-G., Maters C. L., Beyreuther K. RT The promoter of Alzheimer's disease amyloid A4 precursor gene RL EMBO J. 7:2807-2813 (1988). XX // AC G000182 XX ID HS$ACT2 XX DT 14.06.1995 (created); dbo. DT 27.05.2002 (updated); elf. CO Copyright (C), Biobase GmbH. XX SD Act-2 XX SY MIP-1-beta; AT744.1; LAG1; SCYA4; ACT2; lymphocyte-activation gene 1; small SY inducible cytokine A4 (homologous to mouse Mip-1b). XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17q21-q23 XX BC 6.1.5 XX BS -101 -94 R03479; HS$ACT2_01; Binding factors: AP-1 . XX DR EMBL: M69201; HSACT2CK1. DR TRANSPATH: G000182. DR TRRD: 00194. DR LOCUSLINK: 6351. DR OMIM: 182284. DR REFSEQ: NM_002984. XX RN [1] RX MEDLINE; 91373378. RA Napolitano M., Modi W. S., Cevario S. J., Gnarra J. R., Seuanez H. N., RA Leonard W. J. RT The gene encoding the Act-2 cytokine RL J. Biol. Chem. 266:17531-17536 (1991). XX // AC G000183 XX ID HS$ADA XX DT 14.06.1995 (created); dbo. DT 10.02.2000 (updated); sur. CO Copyright (C), Biobase GmbH. XX SD ADA XX DE adenosine deaminase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 20q12-q13.11 XX BC 6.1.4 XX BS -104 -87 R04829; HS$ADA_05; Binding factors: Sp1 . BS -83 -68 R04830; HS$ADA_06; Binding factors: Sp1 . BS -59 -29 R04831; HS$ADA_07; Binding factors: Sp1 . BS 5381 5416 R08588; HS$ADA_08; Binding factors: LEF-1 . BS 9253 9259 R04276; HS$ADA_01. BS 9308 9321 R04277; HS$ADA_02; Binding factors: ADA-NF1 . BS 9330 9340 R04278; HS$ADA_03; Binding factors: LEF-1 . BS 9376 9399 R04279; HS$ADA_04. XX DR EMBL: M13792; HSADAG. DR TRANSPATH: G000183. DR BRENDA: 3.5.4.4; Human. DR LOCUSLINK: 100. DR OMIM: 102700. DR REFSEQ: NM_000022. XX RN [1] RX MEDLINE; 97169230. RA Haynes T. L., Thomas M. B., Dusing M. R., Valerius M. T., Potter S. S., RA Wiginton D. A. RT An enhancer LEF-1/TCF-1 site is essential for insertin site-independent RT transgene expression in thymus RL Nucleic Acids Res. 24:5034-5044 (1996). RN [2] RX MEDLINE; 94173736. RA Dusing M. R., Wiginton D. A. RT Sp1 is essential for both enhancer-mediated and basal activation of the RT TATA-less human adenosine deaminase promoter RL Nucleic Acids Res. 22:669-677 (1994). RN [3] RX MEDLINE; 92375086. RA Aronow B. J., Silbiger R. N., Dusing M. R., Stock J. L., Yager K. L., RA Potter S. S., Hutton J. J., Wiginton D. A. RT Functional analysis of the human adenosine deaminase gene thymic regulatory RT region and its ability to generate position-independent transgene expression RL Mol. Cell. Biol. 12:4170-4185 (1992). XX // AC G000184 XX ID HS$ADH1 XX DT 14.06.1995 (created); dbo. DT 20.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ADH1 XX DE alcohol dehydrogenase 1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q21-q23 XX BC 6.1.4 XX BS -212 -195 R03245; HS$ADH1_01. BS -167 -152 R03246; HS$ADH1_02; Binding factors: C/EBPalpha . BS -135 -108 R03247; HS$ADH1_03. BS -102 -82 R03248; HS$ADH1_04. BS -81 -59 R03249; HS$ADH1_05. BS -55 -7 R03250; HS$ADH1_06; Binding factors: C/EBPalpha . BS -55 -39 R03251; HS$ADH1_07; Binding factors: C/EBPalpha , DBP BS , C/EBPbeta . BS -22 -9 R03252; HS$ADH1_08; Binding factors: C/EBPalpha . XX DR EMBL: M32656; HSADH1X. DR TRANSPATH: G000184. DR BRENDA: 1.1.1.1; Human. DR TRRD: 00378. DR LOCUSLINK: 124. DR OMIM: 103700. DR REFSEQ: NM_000667. XX RN [1] RX MEDLINE; 92318919. RA van Ooij C., Snyder R. C., Paeper B. W., Duester G. RT Temporal expression of the human alcohol dehydrogenase gene family during RT liver development correlates with differential promoter activation by RT hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver RT activator protein, and D-element-bin RL Mol. Cell. Biol. 12:3023-3031 (1992). RN [2] RX MEDLINE; 91268021. RA Stewart M. J., Shean M. L., Paeper B. W., Duester G. RT The role of CCAAT/enhancer-binding protein in the differential regulation RT of a family of human liver alcohol dehydrogenase genes RL J. Biol. Chem. 266:11594-11603 (1991). XX // AC G000185 XX ID HS$ADH2 XX DT 14.06.1995 (created); dbo. DT 21.05.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ADH2 XX DE alcohol dehydrogenase 2 XX SY ADH2-3. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q21-q23 XX BC 6.1.4 XX BS -245 -226 R12420; HS$ADH2_09; Binding factors: GR . BS -224 -205 R12421; HS$ADH2_10; Binding factors: GR . BS -209 -192 R03235; HS$ADH2_08. BS -204 -192 R12423; HS$ADH2_12; Binding factors: HNF-1 . BS -199 -171 R12422; HS$ADH2_11; Binding factors: GR . BS -163 -146 R03130; HS$ADH2_05; Binding factors: C/EBPalpha . BS -129 -104 R03131; HS$ADH2_06; Binding factors: C/EBPalpha . BS -94 -84 R01696; HS$ADH2_01; Binding factors: Sp1 . BS -72 -64 R01697; HS$ADH2_02; Binding factors: USF-1 . BS -51 -31 R03128; HS$ADH2_03; Binding factors: C/EBPalpha , DBP BS , C/EBPbeta . BS -51 -10 R03234; HS$ADH2_07; Binding factors: C/EBPalpha . BS -21 -9 R03129; HS$ADH2_04; Binding factors: C/EBPalpha . XX DR EMBL: M24308; HSADH2E1. DR EMBL: M32657; HSADH2X. DR TRANSPATH: G000185. DR BRENDA: 1.1.1.1; Human. DR TRRD: 00379. DR LOCUSLINK: 125. DR OMIM: 103720. DR REFSEQ: NM_000668. XX RN [1] RX MEDLINE; 92318919. RA van Ooij C., Snyder R. C., Paeper B. W., Duester G. RT Temporal expression of the human alcohol dehydrogenase gene family during RT liver development correlates with differential promoter activation by RT hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver RT activator protein, and D-element-bin RL Mol. Cell. Biol. 12:3023-3031 (1992). RN [2] RX MEDLINE; 91268021. RA Stewart M. J., Shean M. L., Paeper B. W., Duester G. RT The role of CCAAT/enhancer-binding protein in the differential regulation RT of a family of human liver alcohol dehydrogenase genes RL J. Biol. Chem. 266:11594-11603 (1991). RN [3] RX MEDLINE; 90110232. RA Carr L. G., Edenberg H. J. RT cis-Acting Sequences Involved in Protein Binding and in Vitro Transcription RT of the Human Alcohol Dehydrogenase Gene ADH2 RL J. Biol. Chem. 256:1658-1664 (1990). RN [4] RX MEDLINE; 90356026. RA Stewart M. J., Shean M. L., Duester G. RT Trans activation of human alcohol dehydrogenase gene expression in hepatome RT cells by C/EBP molecules bound in a novel arrangement just 5' and 3' to the RT TATA box RL Mol. Cell. Biol. 10:5007-5010 (1990). RN [5] RX MEDLINE; 91007280. RA Winter L. A., Stewart M. J., Shean M. L., Dong Y., Poellinger L., Okret S., RA Gustafsson J. A., Duester G. RT A hormone response element upstream from the human alcohol dehydrogenase RT gene ADH2 consists of three tandem glucocorticoid receptor binding sites. RL Gene 91:233-240 (1990). XX // AC G000186 XX ID HS$ADH3 XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ADH3 XX DE alcohol dehydrogenase 3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q21-q23 XX BC 6.1.4.4 XX BS -328 -272 R03017; HS$ADH3_01; Binding factors: RAR-alpha1 , BS RAR-beta , RXR-alpha , CAR . BS -216 -199 R03236; HS$ADH3_02. BS -166 -148 R03237; HS$ADH3_03; Binding factors: C/EBPalpha . BS -150 -123 R03238; HS$ADH3_04. BS -131 -104 R03239; HS$ADH3_05; Binding factors: C/EBPalpha . BS -98 -78 R03240; HS$ADH3_06. BS -77 -55 R03241; HS$ADH3_07. BS -51 -9 R03242; HS$ADH3_08; Binding factors: C/EBPalpha . BS -51 -31 R03243; HS$ADH3_09; Binding factors: C/EBPalpha , DBP BS , C/EBPbeta . BS -22 -9 R03244; HS$ADH3_10; Binding factors: C/EBPalpha . XX DR EMBL: M32658; HSADH3X. DR TRANSPATH: G000186. DR BRENDA: 1.1.1.1; Human. DR TRRD: 00374. DR LOCUSLINK: 126. DR OMIM: 103730. DR REFSEQ: NM_000669. XX RN [1] RX MEDLINE; 94158827. RA Baes M., Gulick T., Choi H. S., Martinoli M. G., Simha D., Moore D. D. RT A new orphan member of the nuclear hormone receptor superfamily that RT interacts with a subset of retinioc acid response elements RL Mol. Cell. Biol. 14:1544- 1551 (1994). RN [2] RX MEDLINE; 92318919. RA van Ooij C., Snyder R. C., Paeper B. W., Duester G. RT Temporal expression of the human alcohol dehydrogenase gene family during RT liver development correlates with differential promoter activation by RT hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver RT activator protein, and D-element-bin RL Mol. Cell. Biol. 12:3023-3031 (1992). RN [3] RX MEDLINE; 92332521. RA Harding P. P., Duester G. RT Retinoic acid activation and thyroid hormone tepression of the human RT alcohol dehydrogenase gene ADH3 RL J. Biol. Chem. 267:14145-14150 (1992). RN [4] RX MEDLINE; 91268021. RA Stewart M. J., Shean M. L., Paeper B. W., Duester G. RT The role of CCAAT/enhancer-binding protein in the differential regulation RT of a family of human liver alcohol dehydrogenase genes RL J. Biol. Chem. 266:11594-11603 (1991). RN [5] RX MEDLINE; 91141514. RA Duester G., Shean M. L., McBride M. S., Stewart M. J. RT Retinoic acid response element in the human alcohol dehydrogenase gene RT ADH3: implications for regulation of retinoic acid synthesis RL Mol. Cell. Biol. 11:1638-1646 (1991). XX // AC G000187 XX ID HS$ARF3 XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ADPF-3 XX DE ADP-ribosylation factor 3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 12q13 XX BC 6.1.4.2 XX DR TRANSPATH: G000187. DR TRRD: 00127. DR LOCUSLINK: 377. DR OMIM: 103190. DR REFSEQ: NM_001659. XX // AC G000188 XX ID HS$ALBU XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ALB XX DE albumin XX SY HSA; albumin. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q11-q13 XX BC 6.1.3.4 XX BS -476 -439 R02459; HS$ALBU_06; Binding factors: C/EBPalpha , DBP BS . BS -363 -338 R00077; HS$ALBU_01; Binding factors: HNF-1A , HNF-1 BS , HNF-1B , HNF-1C . BS -136 -107 R00078; HS$ALBU_02; Binding factors: NF-1/L . BS -132 -118 R00080; HS$ALBU_04; Binding factors: AFP1 . BS -102 -79 R00079; HS$ALBU_03; Binding factors: NF-1/L . BS -72 -42 R00081; HS$ALBU_05; Binding factors: HNF-1 . XX DR EMBL: M13075; HSALBEX1. DR TRANSPATH: G000188. DR TRRD: 00183. DR LOCUSLINK: 213. DR OMIM: 103600. DR REFSEQ: NM_000477. XX RN [1] RX MEDLINE; 91092271. RA Toniatti C., Demartis A., Monaci P., Nocosia A., Ciliberto G. RT Synergistic trans-activation of the human C-reactive protein promoter by RT transcription factor HNF-1 binding at two distinct sites RL EMBO J. 9:4467-4475 (1990). RN [2] RX MEDLINE; 90158615. RA Frain M., Hardon E., Ciliberto G., Sala-Trepat J. M. RT Binding of a liver-specific factor to the human albumin gene promoter and RT enhancer RL Mol. Cell. Biol. 10:991-999 (1990). RN [3] RX MEDLINE; 91061771. RA Li X., Huang J. H., Rienhoff jr H. Y., Liao W. S.-L. RT Two adjacent C/EBP-binding sequences that participate in the cell-specific RT expression of the mouse serum amyloid A3 gene RL Mol. Cell. Biol. 10:6624-6631 (1990). RN [4] RX MEDLINE; 90003224. RA Frain M., Swart G., Monaci P., Nicosia A., Staempfli S., Frank R., Cortese RA R. RT The liver-specific transcription factor LF-B1 contains a highly diverged RT homeobox DNA binding domain RL Cell 59:145-157 (1989). RN [5] RX MEDLINE; 89030607. RA Paonessa G., Gounari F., Frank R., Cortese R. RT Purification of a NF1-like DNA-binding protein from rat liver and cloning RT of the corresponding cDNA RL EMBO J. 7:3115-3123 (1988). RN [6] RX MEDLINE; 89005060. RA Hardon E. M., Frain M., Paonessa G., Cortese R. RT Two distinct factors interact with the promoter regions of several RT liver-specific genes RL EMBO J. 7:1711-1719 (1988). RN [7] RX MEDLINE; 89218978. RA Sawadaishi K., Morinaga T., Tamaoki T. RT Interaction of a Hepatoma-Specific Nuclear Factor with RT Transcription-Regulatory Sequences of the Human alpha-Fetoprotein and RT Albumin Genes RL Mol. Cell. Biol. 8:5179-5187 (1988). XX // AC G000189 XX ID HS$ALDA XX DT 14.06.1995 (created); dbo. DT 28.08.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ALDA XX DE aldolase A XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 16q22-q24 XX BC 6.1.4.5.3 XX BS -311 -261 R03445; HS$ALDA_01; Binding factors: AP-1 , AP-1 BS , Sp1 , Sp1 . BS -204 -180 R10593; HS$ALDA_05; Binding factors: HIF-1 . BS -190 -165 R03446; HS$ALDA_02. BS -158 -140 R03447; HS$ALDA_03. BS -131 -104 R03448; HS$ALDA_04; Binding factors: Sp1 . BS -87 -70 R11338; HS$ALDA_06; Binding factors: TR2-11 . XX DR EMBL: X06351; HSALDA1. DR EMBL: X12447; HSALDOA. DR TRANSPATH: G000189. DR BRENDA: 4.1.2.13; Human. DR LOCUSLINK: 226. DR OMIM: 103850. DR REFSEQ: NM_000034. XX RN [1] RX MEDLINE; 97339465. RA Chang C., Lee H. J., Lee Y. F. RT Identification of the human aldolase A gene as the first induced target for RT the TR2 orphan receptor, a member of the steroid hormone receptor RT superfamily RL Biochem. Biophys. Res. Commun. 235:205-211 (1997). RN [2] RX MEDLINE; 97115775. RA Semenza G. L., Jiang B. H., Leung S. W., Passantino R., Concordet J. P., RA Maire P., Giallongo A. RT Hypoxia response elements in the aldolase A, enolase 1, and lactate RT dehydrogenase A gene promoters contain essential binding sites for RT hypoxia-inducible factor 1. RL J. Biol. Chem. 271:32529-32537 (1996). RN [3] RX MEDLINE; 91334126. RA Concordet J.-P., Maire P., Kahn A., Daegelen D. RT A ubiquitous enhancer shared by two promoters in the human aldolase A gene RL Nucleic Acids Res. 19:4173-4180 (1991). XX // AC G000190 XX ID HS$ALDB XX DT 21.05.1996 (created); ake. DT 28.08.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ALDB XX DE aldolase B XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.4.5.1 XX DR BRENDA: 4.1.2.13; Human. DR TRRD: 00136. XX // AC G000191 XX ID HS$ALPL XX DT 14.06.1995 (created); dbo. DT 21.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD AlP XX DE alkaline phosphatase, liver/bone/kidney XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1p36.1-p34 XX BS -953 -942 R05105; HS$ALP_02; Binding factors: HNF-3alpha , BS HNF-3B . BS -108 -45 R03927; HS$ALP_01. XX DR EMBL: Y00512; HSALP5. DR TRANSPATH: G000191. DR BRENDA: 3.1.3.1; Human. DR LOCUSLINK: 249. DR OMIM: 171760. DR REFSEQ: NM_000478. XX RN [1] RX MEDLINE; 97184488. RA Ye H., Kelly T. F., Samadani U., Lim L., Rubio S., Overdier D. G., Roebuck RA K. A., Costa R. H. RT Hepatocyte Nuclear Factor 3/ fork head homolog 11 is expressed in RT proliferating epithelial and mesenchymal cells of embryonic and adult RT tissues RL Mol. Biol. Cell 17:1626-1641 (1997). RN [2] RX MEDLINE; 92261620. RA Heath J. K., Suva L. J., Yoon K., Kiledijan M., Martin T. J., Rodan G. A. RT Retinoic acid stimulates transcriptional activity from the alkaline RT phosphatase promoter in the immortalized rat calvarial cell line, RCT-1 RL Mol. Endocrinol. 6:636-646 (1992). XX // AC G000192 XX ID HS$AFP XX DT 21.05.1996 (created); ake. DT 06.09.2001 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD AFP XX DE alpha-fetoprotein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q11-q13 XX BC 6.1.3.4 XX BS -166 -155 R09867; HS$AFP_02; Binding factors: NKX2G . BS 254 268 R09386; HS$AFP_01; Binding factors: AFP1 , ATBF1-B BS . XX DR EMBL: L34019; HSAFPA. DR EMBL: J02693; HSAFPEN. DR TRANSPATH: G000192. DR TRANSCOMPEL: C00289. DR TRRD: 00192. DR LOCUSLINK: 174. DR OMIM: 104150. DR REFSEQ: NM_001134. XX RN [1] RX MEDLINE; 98112842. RA Apergis G. A., Crawford N., Ghosh D., Steppan C. M., Vorachek W. R., Wen RA P., Locker J. RT A novel nk-2-related transcription factor associated with human fetal liver RT and hepatocellular carcinoma RL J. Biol. Chem. 273:2917-2925 (1998). RN [2] RX MEDLINE; 92049333. RA Morinaga T., Yasuda H., Hashimoto T., Higashio K., Tamaoki T. RT A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four RT homeodomains and seventeen zinc fingers RL Mol. Cell. Biol. 11:6041-6049 (1991). RN [3] RX MEDLINE; 89218978. RA Sawadaishi K., Morinaga T., Tamaoki T. RT Interaction of a Hepatoma-Specific Nuclear Factor with RT Transcription-Regulatory Sequences of the Human alpha-Fetoprotein and RT Albumin Genes RL Mol. Cell. Biol. 8:5179-5187 (1988). XX // AC G000193 XX ID HS$AAC XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CA-ACT XX DE cardiac alpha-actin XX SY ACTC1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 15q11-qter XX BC 6.1.2.5.1 XX BS -421 -409 R01752; HS$AAC_09; Binding factors: CTF , NF-1 BS . BS -418 -408 R01753; HS$AAC_14; Binding factors: Sp1 . BS -309 -300 R01754; HS$AAC_10; Binding factors: Sp1 . BS -273 -262 R01755; HS$AAC_15; Binding factors: Sp1 . BS -251 -242 R01756; HS$AAC_11; Binding factors: Sp1 . BS -237 -228 R01757; HS$AAC_12; Binding factors: CBF (4) , SRF BS (504 AA) . BS -213 -203 R01758; HS$AAC_13; Binding factors: Sp1 . BS -200 -191 R01759; HS$AAC_08; Binding factors: SRF (504 AA) . BS -177 -48 R00021; HS$AAC_01; Binding factors: SRF (504 AA) . BS -177 -136 R00022; HS$AAC_02; Binding factors: CBF (2) , SRF BS (504 AA) . BS -127 -119 R00023; HS$AAC_03. BS -117 -92 R00024; HS$AAC_04; Binding factors: SRF , SRF (504 BS AA) . BS -113 -84 R00026; HS$AAC_05; Binding factors: SRF (504 AA) . BS -110 -99 R00027; HS$AAC_06; Binding factors: SRF (504 AA) . BS -109 -99 R00028; HS$AAC_07. BS -84 -66 R01762; HS$AAC_17; Binding factors: Sp1 . BS -56 -49 R02452; HS$AAC_20; Binding factors: MyoD . BS -43 -35 R01760; HS$AAC_19; Binding factors: TUBF . BS -25 -16 R01761; HS$AAC_16; Binding factors: Sp1 . BS 27 36 R01763; HS$AAC_18; Binding factors: Sp1 . XX DR EMBL: M13483; HSACTCA. DR TRANSPATH: G000193. DR TRANSCOMPEL: C00028. DR TRRD: 00036. DR LOCUSLINK: 70. DR OMIM: 102540. DR REFSEQ: NM_005159. XX RN [1] RX MEDLINE; 91065526. RA Sartorelli V., Webster K. A., Kedes L. RT Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, RT CArG-box binding factor, and Sp1 RL Genes Dev. 4:1811-1822 (1990). RN [2] RX MEDLINE; 90294287. RA Tuil D., Clergue N., Montarras D., Pinset Ch., Kahn A., Phan-Dinh-Tuy F. RT CC Ar GG boxes, cis-acting elements with a dual specificity: RT Muscle-specific transcriptional activation and serum responsiveness RL J. Mol. Biol. 213:677-686 (1990). RN [3] RX MEDLINE; 89093119. RA Boxer L. M., Miwa T., Gustafson T. A., Kedes L. RT Identification and Characterization of a Factor That Binds to Two Human RT Sarcomeric Actin Promoters RL J. Biol. Chem. 264:1284-1292 (1989). RN [4] RX MEDLINE; 89219044. RA Boxer L. M., Prywes R., Roeder R. G., Kedes L. RT The Sarcomeric Actin CArG-Binding Factor Is Indistinguishable from the RT c-fos Serum Response Factor RL Mol. Cell. Biol. 9:515-522 (1989). RN [5] RX MEDLINE; 90014780. RA Gustafson T. A., Kedes L. RT Identification of Multiple Proteins That Interact with Functional Regions RT of the Human Cardiac alpha-Actin Promoter RL Mol. Cell. Biol. 9:3269-3283 (1989). RN [6] RX MEDLINE; 89184588. RA Gustafson T. A., Taylor A., Kedes L. RT DNA bending is induced by a transcription factor that interacts with the RT human c-FOS and alpha-actin promoters RL Proc. Natl. Acad. Sci. USA 86:2162-2166 (1989). RN [7] RX MEDLINE; 88225064. RA Phan-Dinh-Tuy F., Tuil D., Schweighoffer F., Pinset C., Kahn A., Minty A. RT The 'CC.Ar.GG' box: A protein-binding site common to RT transcription-regulatory regions of the cardiac actin, c-fos and RT interleukin-2 receptor genes RL Eur. J. Biochem. 173:507-515 (1988). RN [8] RX MEDLINE; 89039835. RA Gustafson T. A., Miwa T., Boxer L. M., Kedes L. RT Interactions of Nuclear Proteins with Muscle-Specific Regulatory Sequences RT of the Human Cardiac alpha-Actin Promoter RL Mol. Cell. Biol. 8:4110-4119 (1988). RN [9] RX MEDLINE; 88016159. RA Miwa T., Boxer L. M., Kedes L. RT CArG boxes in the human cardiac alpha-actin gene are core binding sites for RT positive trans-acting regulatory factors RL Proc. Natl. Acad. Sci. USA 84:6702-6706 (1987). XX // AC G000194 XX ID HS$AACS XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD SA-ACT XX DE skeletal alpha-actin XX SY ACTA. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1q42.13-q42.2 XX BC 6.1.2.5.1 XX BS -273 -249 R08505; HS$AACS_02; Binding factors: ARP-1 . BS -101 -81 R00036; HS$AACS_01; Binding factors: SRF (504 AA) . XX DR EMBL: M20543; HSSAACT. DR TRANSPATH: G000194. DR LOCUSLINK: 58. DR OMIM: 102610. DR REFSEQ: NM_001100. XX RN [1] RX MEDLINE; 95273166. RA Muscat G. E. O., Rea S., Downes M. RT Identification of a regulatory function for an orphan receptor in muscle: RT COUP-TF II affects the expression of the myoD gene family during myogenesis RL Nucleic Acids Res. 23:1311-1318 (1995). RN [2] RX MEDLINE; 89093119. RA Boxer L. M., Miwa T., Gustafson T. A., Kedes L. RT Identification and Characterization of a Factor That Binds to Two Human RT Sarcomeric Actin Promoters RL J. Biol. Chem. 264:1284-1292 (1989). RN [3] RX MEDLINE; 89184588. RA Gustafson T. A., Taylor A., Kedes L. RT DNA bending is induced by a transcription factor that interacts with the RT human c-FOS and alpha-actin promoters RL Proc. Natl. Acad. Sci. USA 86:2162-2166 (1989). RN [4] RX MEDLINE; 89039836. RA Muscat G. E. O., Gustafson T. A., Kedes L. RT A Common Factor Regulates Skeletal and Cardiac alpha-Actin Gene RT Transcription in Muscle RL Mol. Cell. Biol. 8:4120-4133 (1988). XX // AC G000195 XX ID HS$AG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-A XX DE alpha1-globin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 16p13.3 XX BC 6.1.3.10.2 XX BS -882 -872 R02882; HS$AG_02; Binding factors: GATA-1 , GATA-1 BS . BS -840 -832 R02883; HS$AG_03; Binding factors: GATA-1 , GATA-1 BS . BS -233 -210 R04934; HS$AG_16; Binding factors: Sp1 . BS -205 -165 R04935; HS$AG_17; Binding factors: Sp1 . BS -130 -107 R04936; HS$AG_18; Binding factors: Sp1 . BS -90 -65 R00506; HS$AG_01; Binding factors: CTF , CTF-1 BS , CTF-2 , CTF-3 , EFI . BS 12 29 R03437; HS$AG_08; Binding factors: GATA-1 . BS 105 119 R03438; HS$AG_09; Binding factors: GATA-1 , GATA-1 BS . BS 119 141 R03439; HS$AG_10; Binding factors: AP-1 , NF-E2 BS , NF-E2 . BS 154 175 R03440; HS$AG_11; Binding factors: AP-1 , NF-E2 BS , NF-E2 . BS 170 186 R03441; HS$AG_12; Binding factors: CACCC-binding factor BS . BS 192 199 R04336; HS$AG_15; Binding factors: CAC-binding protein BS . BS 212 226 R03442; HS$AG_13; Binding factors: GATA-1 , GATA-1 BS . BS 246 259 R03443; HS$AG_14; Binding factors: GATA-1 , GATA-1 BS . BS 1667 1678 R02884; HS$AG_04; Binding factors: GATA-1 . BS 1903 1913 R02885; HS$AG_05; Binding factors: GATA-1 . BS 1923 1934 R02886; HS$AG_06; Binding factors: GATA-1 , GATA-1 BS . BS 2177 2187 R02887; HS$AG_07; Binding factors: AP-1 , AP-1 BS , NF-E2 , NF-E2 . XX DR EMBL: V00488; HSAGL1. DR EMBL: X04749; HSAGL6. DR EMBL: S49899; HSALPHGLO. DR EMBL: J00153; HSHBA4. DR EMBL: M12604; HSHBARSA. DR TRANSPATH: G000195. DR TRRD: 00427. DR LOCUSLINK: 3039. DR OMIM: 141800. DR REFSEQ: NM_000558. XX RN [1] RX MEDLINE; 95365343. RA Pondel M. D., Murphy S., Pearson L., Craddock C., Proudoot N. J. RT Sp1 functions in a chromatin-dependent manner to augment human alpha-globin RT promoter activity RL Proc. Natl. Acad. Sci. USA 92:7237-7241 (1995). RN [2] RX MEDLINE; 92351709. RA Gourdon G., Morle F., Roche J., Tourneur N., Joulain V., Godet J. RT Identification of GATA-1 and NF-E2 binding sites in the flanking regions of RT the human alpha-globin genes. RL Acta Haematol. 87:136-144 (1992). RN [3] RX MEDLINE; 92186836. RA Thompson C. B., Wang C.-Y., Ho I-C., Bohjanen P. R., Petryniak B., June C. RA H., Miesfeldt S., Zhang L., Nabel G. J., Karpinski B., Leiden J. M. RT cis-acting sequences required for inducible interleukin-2 enhancer function RT bind a novel Ets-related protein, Elf-1 RL Mol. Cell. Biol. 12:1043-1053 (1992). RN [4] RX MEDLINE; 92236588. RA Strauss E. C., Andrews N. C., Higgs D. R., Orkin S. H. RT In vivo footprinting of the human alpha-globin locus upstream regulatory RT element by guanine and adenine ligation-mediated polymerase chain reaction RL Mol. Cell. Biol. 12:2135- 2142 (1992). RN [5] RX MEDLINE; 91342671. RA Jarman A. P., Wood W. G., Sharpe J. A., Gourdon G., Ayyub H., Higgs D. R. RT Characterization of the major regulatory element upstream of the human RT alpha-globin gene cluster RL Mol. Cell. Biol. 11:4679-4689 (1991). RN [6] RX MEDLINE; 91093062. RA Faber M., Sealy L. RT Rous sarcoma virus enhancer factor I is a ubiquitous CCAAT transcription RT factor highly related to CBF and NF-Y RL J. Biol. Chem. 265:22243-22254 (1990). RN [7] RX MEDLINE; 89354548. RA Mermod N., O'Neill E. A., Kelly T. J., Tjian R. RT The Proline-Rich Transcriptional Activator of CTF/NF-I Is Distinct from the RT Replication and DNA Binding Domain RL Cell 58:741-753 (1989). RN [8] RX MEDLINE; 88288392. RA Santoro C., Mermod N., Andrews P. C., Tjian R. RT A family of human CCAAT-box-binding proteins active in transcription and RT DNA replication: cloning and expression of multiple cDNAs RL Nature 334:218-224 (1988). RN [9] RX MEDLINE; 87078403. RA Jones K. A., Kadonaga J. T., Rosenfeld P. J., Kelly T. J., Tjian R. RT A cellular DNA-binding protein that activates eukaryotic transcription and RT replication RL Cell 48:79-89 (1987). XX // AC G000196 XX ID HS$CAMHC XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD alpha-MHC XX DE cardiac alpha-myosin heavy chain XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.2.5.2 XX BS -159 -130 R03942; HS$CAMHC_01; Binding factors: RAR-alpha1 , BS T3R-alpha , T3R-beta1 , T3R-beta1 , RXR-beta BS , T3R-beta2 , Hp55 , Hp65 , p58 , BS T3R-beta1 , T3R-beta2 . XX DR EMBL: Z20656; HSCAMHCA. DR TRANSPATH: G000196. XX RN [1] RX MEDLINE; 92103690. RA Yu V. C., Delsert C., Andersen B., Holloway J. M., Devary O. V., Naeaer A. RA M., Kim S. Y., Boutin J. M., Glass C. K., Rosenfeld M. G. RT RXRbeta: a coregulator that enhances binding of retinoic acid, thyroid RT hormone, and vitamin D receptors of their cognate response elements RL Cell 67:1251-1266 (1991). RN [2] RX MEDLINE; 92063894. RA Yen P. M., Darling D. S., Chin W. W. RT Basal and thyroid hormone receptor auxiliary protein-enhanced binding of RT thyroid hormone receptor isoforms to native thyroid hormone response RT elements RL Endocrinology 129:3331-3336 (1991). RN [3] RX MEDLINE; 91029504. RA Glass C. K., Devary O. V., Rosenfeld M. G. RT Multiple cell type-specific proteins differentially regulate target RT sequence recognition by the alpha retinoic acid receptor RL Cell 63:729-738 (1990). XX // AC G000197 XX ID HS$AMHC XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MHC-alpha XX DE alpha-myosin heavy chain XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.2.5.2 XX BS -129 -111 R02714; HS$AMHC_02; Binding factors: T3R-beta . XX DR EMBL: Z20656; HSCAMHCA. DR TRANSPATH: G000197. XX RN [1] RX MEDLINE; 90293069. RA Flink I. L., Morkin E. RT Interaction of Thyroid Hormone Receptors with Strong and Weak cis-Acting RT Elements in the Human alpha-Myosin Heavy Chain Gene Promoter RL J. Biol. Chem. 265:11233-11237 (1990). XX // AC G000198 XX ID HS$A11COL XX DT 14.06.1995 (created); dbo. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD A1(1) COL XX DE alpha1 (I) collagen XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17q21.3-q22 XX BC 6.1.2.7 XX BS empty empty R02566; HS$A11COL_05. BS empty empty R02567; HS$A11COL_06. BS empty empty R02568; HS$A11COL_07. BS empty empty R02569; HS$A11COL_08. BS -477 -255 R00226; HS$A11COL_03. BS 820 1093 R00227; HS$A11COL_04. BS 919 944 R00224; HS$A11COL_01; Binding factors: Sp1 . BS 950 1009 R00225; HS$A11COL_02. XX DR EMBL: M20789; HSC1A1. DR EMBL: J02829; HSCG1A1P. DR EMBL: K01228; HSCG1PA1. DR EMBL: M32798; HSCOL141. DR EMBL: M55998; HSCOL1A1Z. DR EMBL: J03559; HSCOLA1I. DR TRANSPATH: G000198. DR PATHODB: MR000030. DR LOCUSLINK: 1277. DR OMIM: 120150. DR REFSEQ: NM_000088. XX RN [1] RX MEDLINE; 89384540. RA Herget T., Burba M., Schmoll M., Zimmermann K., Starzinski-Powitz A. RT Regulated Expression of Nuclear Protein(s) in Myogenic Cells That Binds to RT a Conserved 3' Untranslated Region in Proalpha1(I) Collagen cDNA RL Mol. Cell. Biol. 9:2828-2836 (1989). RN [2] RX MEDLINE; 89096858. RA Bornstein P., McKay J., Liska D. J., Apone S., Devarayalu S. RT Interaction between the Promoter and First Intron are Involved in RT Transcriptional Control of alpha1(I) Collagen Gene Expression RL Mol. Cell. Biol. 8:4851-4857 (1988). RN [3] RX MEDLINE; 88097389. RA Bornstein P., McKay J., Morishima J. K., Devarayalu S., Gelinas R. E. RT Regulatory elements in the first intron contribute to transcriptional RT control of the human alpha1(I) collagen gene RL Proc. Natl. Acad. Sci. USA 84:8869-8873 (1987). XX // AC G000199 XX ID HS$A1ANTR XX DT 14.06.1995 (created); dbo. DT 14.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD alpha1-AT XX DE alpha1-antitrypsin XX SY PI; PI1; AAT; A1A; alpha-1-antitrypsin. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 14q32.1 XX BC 6.1.4.7.1 XX BS -134 -98 R00114; HS$A1ANTR_01; Binding factors: HNF-4alpha1 , BS LF-A1 , HNF-4alpha2 , HNF-4alpha1 . BS -128 -103 R00115; HS$A1ANTR_02; Binding factors: LF-A1 . BS -125 -96 R00116; HS$A1ANTR_03; Binding factors: LF-A1 . BS -97 -86 R00117; HS$A1ANTR_04; Binding factors: LF-A2 . BS -86 -56 R00118; HS$A1ANTR_05; Binding factors: HNF-1 , HNF-1B BS . BS -85 -66 R00119; HS$A1ANTR_06; Binding factors: LF-B2 , AT-BP1 BS , AT-BP2 . BS -80 -57 R00120; HS$A1ANTR_07; Binding factors: HNF-1 . BS -80 -52 R00121; HS$A1ANTR_08; Binding factors: HNF-1 . BS -78 -52 R00122; HS$A1ANTR_09. BS -78 -62 R00123; HS$A1ANTR_10; Binding factors: HNF-1 , HP1 BS site factor . BS -46 -23 R00124; HS$A1ANTR_11; Binding factors: LF-C . XX DR EMBL: K02212; HSA1ATP. DR TRANSPATH: G000199. DR TRANSCOMPEL: C00279. DR SMARTDB: SM0000111. DR SMARTDB: SM0000217. DR SMARTDB: SM0000218. DR SMARTDB: SM0000219. DR LOCUSLINK: 5265. DR OMIM: 107400. DR REFSEQ: NM_000295. XX RN [1] RX MEDLINE; 91224095. RA de Simone V., de Magistris L., Lazzaro D., Gerstner J., Monaci P., Nicosia RA A., Cortese R. RT LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed RT in specialized epithelia RL EMBO J. 10:1435-1443 (1991). RN [2] RX MEDLINE; 91187610. RA Mitchelmore C., Traboni C., Cortese R. RT Isolation of two cDNAs encoding zinc finger proteins which bind to the RT alpha1-antitrypsin promoter and to the major histocompatibility complex RT class I enhancer RL Nucleic Acids Res. 19:141-147 (1991). RN [3] RX MEDLINE; 91122637. RA Sladek F. M., Zhong W., Lai E., Darnell jr J. E. RT Liver-enriched transcription factor HNF-4 is a novel member of the steroid RT hormone receptor superfamily RL Genes Dev. 4:2353-2365 (1990). RN [4] RX MEDLINE; 90256819. RA Rangan V. S., Das G. C. RT Purification and Biochemical Characterization of Hepatocyte Nuclear Factor RT 2 Involved in Liver-specific Transcription of the Human alpha1-Antitrypsin RT Gene RL J. Biol. Chem. 265:8874-8879 (1990). RN [5] RX MEDLINE; 89098374. RA Ochoa A., Brunel F., Mendelzon D., Cohen G. N., Zakin M. M. RT Different liver nuclear proteins bind to similar sequences in the 5' RT flanking regions of three hepatic genes RL Nucleic Acids Res. 17:119-133 (1989). RN [6] RX MEDLINE; 89005060. RA Hardon E. M., Frain M., Paonessa G., Cortese R. RT Two distinct factors interact with the promoter regions of several RT liver-specific genes RL EMBO J. 7:1711-1719 (1988). RN [7] RX MEDLINE; 88328996. RA Monaci P., Nicosia A., Cortese R. RT Two different liver-specific factors stimulate in vitro transcription from RT the human alpha1-antitrypsin promoter RL EMBO J. 7:2075-2087 (1988). RN [8] RX MEDLINE; 89039864. RA Li Y., Shen R.-F., Tsai S. Y., Woo S. L. C. RT Multiple Hepatic trans-Acting Factors Are Required for In Vitro RT Transcription of the Human Alpha-1-Antitrypsin Gene RL Mol. Cell. Biol. 8:4362-4369 (1988). RN [9] RX MEDLINE; 88233915. RA Kugler W., Wagner U., Ryffel G. U. RT Tissue-specificity of liver gene expression: a common liver-specific RT promoter element RL Nucleic Acids Res. 16:3165-3174 (1988). RN [10] RX MEDLINE; 88040463. RA Shen R.-F., Li Y., Sifers R. N., Wang H., Hardick C., Tsai S. Y., Woo S. L. RA C. RT Tissue-specific expression of the human alpha1-antitrypsin gene is RT controlled by multiple cis-regulatory elements RL Nucleic Acids Res. 15:8399-8415 (1987). RN [11] RX MEDLINE; 88042798. RA Courtois G., Morgan J. G., Campbell L. A., Fourel G., Crabtree G. R. RT Interaction of a liver-specific nuclear factor with the fibrinogen and RT alpha1-antitrypsin promoters RL Science 238:688-692 (1987). XX // AC G000200 XX ID HS$ANF XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ANF XX DE atrial natriuretic factor XX SY ANP; PND; NPPA. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1 XX BC 6.1.5.7 XX BS -400 -208 R00158; HS$ANF_01. BS -369 -352 R00159; HS$ANF_02. BS -251 -225 R04330; HS$ANF_03; Binding factors: c-Fos , c-Jun BS . XX DR EMBL: K02043; HSANF. DR TRANSPATH: G000200. DR TRRD: 00195. DR LOCUSLINK: 90230. XX RN [1] RX MEDLINE; 92107180. RA Kovacic-Milivojevic B., Gardner D. G. RT Divergent regulation of the human atrial natriuretic peptide gene by c-jun RT and c-fos RL Mol. Cell. Biol. 12:292-301 (1992). RN [2] RX MEDLINE; 89197955. RA Wu J., LaPointe M. C., West B. L., Gardner D. G. RT Tissue-specific Determinants of Human Atrial Natriuretic Factor Gene RT Expression in Cardiac Tissue RL J. Biol. Chem. 264:6472-6479 (1989). RN [3] RX MEDLINE; 88243782. RA LaPointe M. C., Wu J., Greenberg B., Gardner D. G. RT Upstream Sequences Confer Atrial-specific Expression on the Human Atrial RT Factor Gene RL J. Biol. Chem. 263:9075-9078 (1988). XX // AC G000201 XX ID HS$ANT1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ANT1 XX DE heart-skeletal muscle adenine nucleotide translocator XX SY SLC25A4. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4 XX BS -477 -438 R02862; HS$ANT1_01. XX DR EMBL: J04982; HSANT1. DR LOCUSLINK: 113517. XX RN [1] RX MEDLINE; 91056111. RA Li K., Hodge J. A., Wallace D. C. RT OXBOX, a positive transcriptional element of the heart-skeletal muscle RT ADP/ATP translocator gene RL J. Biol. Chem. 265:20585-20588 (1990). XX // AC G000202 XX ID HS$ANTHIII XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD AT3 XX DE antithrombin III XX SY antithrombinIII; ATIII. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1q23-q25.1 XX BS -89 -68 R00113; HS$ANTHIII_01; Binding factors: Tf-LF1 . XX DR EMBL: X00237; HSATH1. DR TRANSPATH: G000202. DR LOCUSLINK: 462. DR OMIM: 107300. DR REFSEQ: NM_000488. XX RN [1] RX MEDLINE; 89098374. RA Ochoa A., Brunel F., Mendelzon D., Cohen G. N., Zakin M. M. RT Different liver nuclear proteins bind to similar sequences in the 5' RT flanking regions of three hepatic genes RL Nucleic Acids Res. 17:119-133 (1989). XX // AC G000203 XX ID HS$APOA1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD apoAI XX DE apolipoprotein AI XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11q23-q24 XX BC 6.1.3.3 XX BS -221 -195 R00135; HS$APOA1_01; Binding factors: AID2 , ARP-1 BS , COUP-TF1 , LF-A1 , NF-BA1 , RAR-alpha1 BS , RAR-beta , RXR-alpha . BS -175 -146 R02959; HS$APOA1_02; Binding factors: AIC2 , AIC3 BS , AIC4 , AIC5 , CBF (2) . BS -134 -118 R02960; HS$APOA1_03; Binding factors: ARP-1 . BS -114 -108 R03083; HS$APOA1_04. BS -22 17 R03084; HS$APOA1_05. XX DR EMBL: J04066; HSAPOA01. DR EMBL: M20656; HSAPOA02. DR EMBL: J00098; HSAPOAI1. DR EMBL: X01038; HSAPOAIA. DR EMBL: X07496; HSAPOAIT. DR TRANSPATH: G000203. DR TRANSCOMPEL: C00123. DR TRRD: 00264. DR LOCUSLINK: 335. DR OMIM: 107680. DR REFSEQ: NM_000039. XX RN [1] RX MEDLINE; 96071177. RA Butler A. J., Parker M. G. RT COUP-TF II homodimers are formed in preference to heterodimers with RT RXRalpha or TRbeta in intact cells RL Nucleic Acids Res. 23:4143-4150 (1995). RN [2] RX MEDLINE; 92365821. RA Zhang X.-K., Lehmann J., Hoffmann B., Dawson M. I., Cameron J., Graupner RA G., Hermann T., Tran P., Pfahl M. RT Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid RL Nature 358:587-591 (1992). RN [3] RX MEDLINE; 93024411. RA Tran P., Zhang X.-K., Salbert G., Hermann T., Lehmann J. M., Pfahl M. RT COUP orphan receptors are negative regulators of retinoic acid response RT pathways RL Mol. Cell. Biol. 12:4666-4676 (1992). RN [4] RX MEDLINE; 92334336. RA Widom R. L., Rhee M., Karathanasis S. K. RT Repression by ARP-1 sensitizes apolipoprotein AI gene responsiveness to RT RXRalpha and retinoic acid RL Mol. Cell. Biol. 12:3380-3389 (1992). RN [5] RX MEDLINE; 91170257. RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., Monaci P., Cladaras C., RA Zannis V. I. RT Promoter elements and factors involved in hepatic transcription of the RT human ApoA-I gene positive and negative regulators bind to overlapping sites RL J. Biol. Chem. 266:5790-5797 (1991). RN [6] RX MEDLINE; 91117233. RA Widom R. L., Ladias J. A. A., Kouidou S., Karathanasis S. K. RT Synergistic interactions between transcription factors control expression RT of the apolipoprotein AI gene in liver cells RL Mol. Cell. Biol. 11:677-687 (1991). RN [7] RX MEDLINE; 91260732. RA Rottman J. N., Widom R. L., Nadal-Ginard B., Mahdavi V., Karathanasis S. K. RT A retinoic acid-responsive element in the apolipoprotein A1 gene RT distinguishes between two different retinoic acid response pathways RL Mol. Cell. Biol. 11:3814-3820 (1991). RN [8] RX MEDLINE; 91118002. RA Ladias J. A. A., Karathanasis S. K. RT Regulation of the apolipoprotein A1 gene by ARP-1, a novel member of the RT steroid receptor superfamily RL Science 251:561-565 (1991). RN [9] RX MEDLINE; 91072376. RA Kardassis D., Zannis V. I., Claradas C. RT Purification and characterization of the nuclear factor BA1 RL J. Biol. Chem. 265:31733-21740 (1990). RN [10] RX MEDLINE; 89005060. RA Hardon E. M., Frain M., Paonessa G., Cortese R. RT Two distinct factors interact with the promoter regions of several RT liver-specific genes RL EMBO J. 7:1711-1719 (1988). XX // AC G000204 XX ID HS$APOA2 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD apoAII XX DE apolipoprotein AII XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1q21-q23 XX BC 6.1.3.3 XX BS -903 -879 R03260; HS$APOA2_15; Binding factors: HNF-1A , HNF-1 BS , AIIN3 , AIIN3 , HNF-1B , HNF-1C . BS -851 -832 R00136; HS$APOA2_01. BS -804 -769 R00138; HS$APOA2_03; Binding factors: C/EBPalpha , E BS . BS -799 -771 R00137; HS$APOA2_02. BS -756 -740 R00139; HS$APOA2_04. BS -735 -714 R00140; HS$APOA2_05; Binding factors: NF-BA1 , Tf-LF1 BS . BS -703 -678 R00141; HS$APOA2_06. BS -573 -554 R03253; HS$APOA2_08; Binding factors: HNF-1 . BS -468 -455 R03254; HS$APOA2_09. BS -404 -384 R03255; HS$APOA2_10. BS -377 -364 R03256; HS$APOA2_11. BS -276 -255 R03257; HS$APOA2_12. BS -126 -110 R03258; HS$APOA2_13. BS -65 -48 R03187; HS$APOA2_07; Binding factors: CIIIB1 . BS -40 -33 R03259; HS$APOA2_14. XX DR EMBL: X04898; HSAPOA2. DR EMBL: X02905; HSAPOA2G. DR TRANSPATH: G000204. DR TRANSCOMPEL: C00288. DR TRRD: 00148. DR LOCUSLINK: 336. DR OMIM: 107670. DR REFSEQ: NM_001643. XX RN [1] RX MEDLINE; 91236737. RA Ogami K., Kardassis D., Cladaras C., Zannis V. I. RT Purification and characterization of a heat stable nuclear factor CIIIB1 RT involved in the regulation of the human apoC-III gene RL J. Biol. Chem. 266:9640-9646 (1991). RN [2] RX MEDLINE; 91268033. RA Chambaz J., Cardot P., Pastier D., Zannis V. I., Cladaras C. RT Promoter elements and factors required for hepatic transcription of the RT human apoA-II gene RL J. Biol. Chem. 266:11676-11685 (1991). RN [3] RX MEDLINE; 91072376. RA Kardassis D., Zannis V. I., Claradas C. RT Purification and characterization of the nuclear factor BA1 RL J. Biol. Chem. 265:31733-21740 (1990). RN [4] RX MEDLINE; 89202040. RA Lucero M. A., Sanchez D., Ochoa A. R., Brunel F., Cohen G. N., Baralle F. RA E., Zakin M. M. RT Interaction of DNA-binding proteins with the tissue-specific human RT apolipoprotein-AII enhancer RL Nucleic Acids Res. 17:2283-2300 (1989). XX // AC G000205 XX ID HS$APOB XX DT 14.06.1995 (created); dbo. DT 30.07.2001 (updated); ili. CO Copyright (C), Biobase GmbH. XX SD apoB XX DE apolipoprotein B XX SY ApoB-100. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 2p24-p23 XX BC 6.1.3.3 XX BS empty empty R03663; HS$APOB_12; Binding factors: CACCC-binding factor BS . BS -3018 -2969 R03679; HS$APOB_17. BS -2965 -2917 R03680; HS$APOB_18. BS -2914 -1892 R03681; HS$APOB_19. BS -2887 -2779 R03682; HS$APOB_20. BS -2777 -2760 R03683; HS$APOB_21. BS -2696 -2616 R04011; HS$APOB_31. BS -2612 -2599 R04012; HS$APOB_32. BS -2596 -2562 R04013; HS$APOB_33. BS -2164 -2093 R04014; HS$APOB_34. BS -2088 -2064 R04015; HS$APOB_35. BS -2060 -2025 R04016; HS$APOB_36. BS -2023 -2008 R04017; HS$APOB_37. BS -822 -802 R03684; HS$APOB_22. BS -800 -780 R03685; HS$APOB_23. BS -740 -708 R03686; HS$APOB_24. BS -694 -674 R03687; HS$APOB_25. BS -527 -505 R03688; HS$APOB_26. BS -455 -420 R03689; HS$APOB_27. BS -245 -237 R03690; HS$APOB_28. BS -234 -220 R03691; HS$APOB_29. BS -155 -134 R03692; HS$APOB_30. BS -126 -91 R02679; HS$APOB_03; Binding factors: TGT3 . BS -86 -61 R01612; HS$APOB_01; Binding factors: AF-1 , AF-1 BS , ARP-1 , NF-BA1 , AF-1 . BS -69 -52 R01613; HS$APOB_02; Binding factors: C/EBPalpha . BS 33 52 R02681; HS$APOB_05. BS 394 401 R03657; HS$APOB_06; Binding factors: C/EBPalpha . BS 405 413 R03658; HS$APOB_07. BS 419 437 R03659; HS$APOB_08. BS 451 463 R03660; HS$APOB_09. BS 477 492 R03661; HS$APOB_10; Binding factors: AP-2alphaA , BS AP-2alphaB . BS 660 708 R03662; HS$APOB_11; Binding factors: LF-A1 . BS 746 770 R03664; HS$APOB_13; Binding factors: NF-1 . BS 783 803 R03665; HS$APOB_14. BS 835 876 R04254; HS$APOB_38; Binding factors: HNF-1A . BS 839 935 R03666; HS$APOB_15; Binding factors: AP-2alphaA , BS CACCC-binding factor , C/EBPalpha , HNF-1A , Sp1 BS , HNF-3B , HNF-3 , HNF-1A , HNF-1B BS , HNF-1C , HNF-3 , AP-2alphaB , HNF-3 BS . BS 878 912 R04255; HS$APOB_39; Binding factors: C/EBPalpha . BS 892 904 R08918; HS$APOB_40; Binding factors: HNF-3B . BS 960 991 R03667; HS$APOB_16. XX DR EMBL: M19808; HSAPB01. DR EMBL: M19809; HSAPB02. DR EMBL: M15053; HSAPOBA1. DR EMBL: J02630; HSAPOBG. DR EMBL: X16152; HSAPOBPRM. DR TRANSPATH: G000205. DR TRANSCOMPEL: C00122. DR SMARTDB: SM0000107. DR SMARTDB: SM0000108. DR SMARTDB: SM0000109. DR SMARTDB: SM0000342. DR TRRD: 00149. DR LOCUSLINK: 338. DR OMIM: 107730. DR REFSEQ: NM_000384. XX RN [1] RX MEDLINE; 97042457. RA Samadani U., Costa R. H. RT The transcriptional activator hepatocyte nuclear factor 6 regulates liver RT gene expression RL Mol. Cell. Biol. 16:6273-6284 (1996). RN [2] RX MEDLINE; 92186845. RA Brooks A. R., Levy-Wilson B. RT Hepatocyte nuclear factor 1 and C/EBP are essential for the activity of the RT human apolipoprotein B gene second-intron enhancer RL Mol. Cell. Biol. 12:1134-1148 (1992). RN [3] RX MEDLINE; 91210311. RA Brooks A. R., Blackhart B. D., Haunbold K., Levy-Wilson B. RT Characterization of tissue-specific enhancer elements in the second intron RT of the human apolipoprotein B gene RL J. Biol. Chem. 266:7848-7859 (1991). RN [4] RX MEDLINE; 92084725. RA Paulweber B., Onasch M. A., Nagy B. P., Levy-Wilson B. RT Similarities and differences in the function of regulatory elements at the RT 5' end of the human apolipoprotein B gene in cultured hepatoma (HepG2) and RT colon carcinoma (CaCo-2) cells RL J. Biol. Chem. 266:24149-24160 (1991). RN [5] RX MEDLINE; 92084726. RA Paulweber B., Levy-Wilson B. RT The mechanism by which a human apolipoprotein B gene enhancer and reducer RT interact with the promoter are different in cultured ells of hepatic and RT intestinal origin RL J. Biol. Chem. 266:24161-24168 (1991). RN [6] RX MEDLINE; 92042110. RA Paulweber B., Brooks A. R., Nagy B. P., Levy-Wilson B. RT Identification of a negative regulatory region 5' of the human RT apolipoprotein B promoter RL J. Biol. Chem. 266:21956-21961 (1991). RN [7] RX MEDLINE; 91118002. RA Ladias J. A. A., Karathanasis S. K. RT Regulation of the apolipoprotein A1 gene by ARP-1, a novel member of the RT steroid receptor superfamily RL Science 251:561-565 (1991). RN [8] RX MEDLINE; 91072376. RA Kardassis D., Zannis V. I., Claradas C. RT Purification and characterization of the nuclear factor BA1 RL J. Biol. Chem. 265:31733-21740 (1990). RN [9] RX MEDLINE; 90258851. RA Kardassis D., Hadzopoulou-Cladaras M., Ramji D. P., Cortese R., Zannis V. RA I., Cladaras C. RT Characterization of the Promoter Elements Required for Hepatic and RT Intestinal Transcription of the Human apoB Gene: Definition of the RT DNA-Binding Site of a Tissue-Specific Transcriptional Factor RL Mol. Cell. Biol. 10:2653-2659 (1990). RN [10] RX MEDLINE; 90277694. RA Metzger S., Leff T., Breslow J. L. RT Nuclear factors AF-1 and C/EBP bind to the human ApoB gene promoter and RT modulate its transcriptional activity in hepatic cells RL J. Biol. Chem. 265:9978-9983 (1990). XX // AC G000206 XX ID HS$APOC3 XX DT 14.06.1995 (created); dbo. DT 25.04.2000 (updated); rio. CO Copyright (C), Biobase GmbH. XX SD apoCIII XX DE apolipoprotein CIII XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11q23-qter XX BC 6.1.3.3 XX BS -745 -725 R08883; HS$APOC3_02; Binding factors: HNF-4 . BS -700 -680 R08884; HS$APOC3_03. BS -93 -71 R02657; HS$APOC3_01; Binding factors: AF-1 , ARP-1 BS , COUP-TF1 , HNF-4alpha1 , NF-BA1 , CIIIB1 BS , AF-1 , HNF-4alpha2 , HNF-4alpha1 . XX DR EMBL: X03120; HSAPC3G. DR EMBL: M60674; HSAPOCP. DR TRANSPATH: G000206. DR TRANSCOMPEL: C00018. DR TRRD: 00196. DR LOCUSLINK: 345. DR OMIM: 107720. DR REFSEQ: NM_000040. XX RN [1] RX MEDLINE; 95378251. RA Bisaha J. G., Simon T. C., Gordon J. I., Breslow J. L. RT Characterization of an enhancer element in the human apolipoprotein C-III RT gene that regulates human apolipoprotein A-I gene expression in the RT intestinal epithelium RL J. Biol. Chem. 270:19979-19988 (1995). RN [2] RX MEDLINE; 92195317. RA Mietus-Snyder M., Sladek F. M., Ginsburg G. S., Kuo C. F., Ladias J. A. A., RA Darnell jr J. E., Karathanasis S. K. RT Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, RT and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene RT expression in liver and intestinal cells RL Mol. Cell. Biol. 12:1708-1718 (1992). RN [3] RX MEDLINE; 91236737. RA Ogami K., Kardassis D., Cladaras C., Zannis V. I. RT Purification and characterization of a heat stable nuclear factor CIIIB1 RT involved in the regulation of the human apoC-III gene RL J. Biol. Chem. 266:9640-9646 (1991). RN [4] RX MEDLINE; 91118002. RA Ladias J. A. A., Karathanasis S. K. RT Regulation of the apolipoprotein A1 gene by ARP-1, a novel member of the RT steroid receptor superfamily RL Science 251:561-565 (1991). RN [5] RX MEDLINE; 91122637. RA Sladek F. M., Zhong W., Lai E., Darnell jr J. E. RT Liver-enriched transcription factor HNF-4 is a novel member of the steroid RT hormone receptor superfamily RL Genes Dev. 4:2353-2365 (1990). RN [6] RX MEDLINE; 91072376. RA Kardassis D., Zannis V. I., Claradas C. RT Purification and characterization of the nuclear factor BA1 RL J. Biol. Chem. 265:31733-21740 (1990). RN [7] RX MEDLINE; 89380213. RA Leff T., Reue K., Melian A., Culver H., Breslow J. L. RT A Regulatory Element in the ApoCIII Promoter That Directs Hepatic Specific RT Transcription Binds to Proteins in Expressing and Nonexpressing Cell Types RL J. Biol. Chem. 264:16132-16137 (1989). XX // AC G000207 XX ID HS$APOE XX DT 14.06.1995 (created); dbo. DT 14.05.2001 (updated); mas. CO Copyright (C), Biobase GmbH. XX SD apoE XX DE apolipoprotein E XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 19q13.2 XX BC 6.1.3.3 XX BS empty empty R09980; HS$APOE_12; Binding factors: RXR-alpha , BS LXR-alpha , LXR-beta . BS -336 -315 R00142; HS$APOE_01; Binding factors: SRF . BS -241 -233 R00143; HS$APOE_02. BS -187 -167 R00144; HS$APOE_03; Binding factors: ER-alpha . BS -165 -144 R00145; HS$APOE_04. BS -161 -141 R00146; HS$APOE_05. BS -157 -146 R00147; HS$APOE_06. BS -104 -86 R00148; HS$APOE_07. BS -61 -44 R00149; HS$APOE_08; Binding factors: Sp1 . BS -59 -45 R00150; HS$APOE_09; Binding factors: Sp1 , Sp1 BS . BS 69 87 R00151; HS$APOE_10. BS 173 191 R00152; HS$APOE_11. XX DR EMBL: AJ249921; HSA249921. DR EMBL: M10065; HSAPOE4. DR TRANSPATH: G000207. DR TRRD: 00151. DR LOCUSLINK: 348. DR OMIM: 107741. DR REFSEQ: NM_000041. XX RN [1] RX MEDLINE; 21143338. RA Laffitte B. A., Repa J. J., Joseph S. B., Wilpitz D. C., Kast H. R., RA Mangelsdorf D. J., Tontonoz P. RT LXRs control lipid-inducible expression of the apolipoprotein E gene in RT macrophages and adipocytes RL Proc. Natl. Acad. Sci. USA 98:507-512 (2001). RN [2] RX MEDLINE; 88228059. RA Smith J. D., Melian A., Leff T., Breslow J. L. RT Expression of the Human Apolipoprotein E Gene is Regulated by Multiple RT Positive and Negative Elements RL J. Biol. Chem. 263:8300-8308 (1988). RN [3] RX MEDLINE; 88330840. RA Paik Y.-K., Chang D. J., Reardon C. A., Walker M. D., Taxman E., Taylor J. RA M. RT Identification and Characterization of Transcriptional Regulatory Regions RT Associated with Expression of the Human Apolipoprotein E Gene RL J. Biol. Chem. 263:13340-13349 (1988). XX // AC G000209 XX ID HS$APOD XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ApoD XX DE apolipoprotein D XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 3q26.2-qter XX BC 6.1.3.3 XX DR TRRD: 00150. DR LOCUSLINK: 347. DR OMIM: 107740. DR REFSEQ: NM_001647. XX // AC G000210 XX ID HS$ASCC XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD AS XX DE argininosuccinate synthetase XX SY CTLN1; ASS1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 9q34-qter XX BS -120 -109 R03051; HS$ASCC_01; Binding factors: Sp1 . BS -108 -88 R03052; HS$ASCC_02; Binding factors: Sp1 . BS -56 -38 R03053; HS$ASCC_03; Binding factors: Sp1 . BS -30 -26 R03054; HS$ASCC_04. XX DR EMBL: L00077; HSAS01. DR TRANSPATH: G000210. DR BRENDA: 6.3.4.5; Human. DR LOCUSLINK: 445. DR OMIM: 603470. DR REFSEQ: NM_000050. XX RN [1] RX MEDLINE; 91172179. RA Anderson G. M., Freytag S. O. RT Synergistic activation of a human promoter in vivo by transcription factor RT Sp1 RL Mol. Cell. Biol. 11:1935-1943 (1991). XX // AC G000211 XX ID HS$BATPS XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ATPSB XX DE ATP synthase beta-subunit XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 12p13-qter XX BS 390 0 R03474; HS$BATPS_01. XX DR EMBL: M19482; HSATPSY1. DR EMBL: M27132; HSATPSYB. DR BRENDA: 3.6.1.34. DR LOCUSLINK: 506. DR OMIM: 102910. DR REFSEQ: NM_001686. XX RN [1] RX MEDLINE; 92017844. RA Virbasius J. V., Scarpulla R. C. RT Transcriptional activation through ETS domain binding sites in the RT cytochrome c oxidase subunit IV gene RL Mol. Cell. Biol. 11:5631-5638 (1991). XX // AC G000212 XX ID HS$BCR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD BCR XX DE breakpoint cluster region protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 22q11 XX BS -1388 -1374 R02834; HS$BCR_01. BS -1354 -1342 R02835; HS$BCR_02. BS -1327 -1313 R02836; HS$BCR_03. BS -1283 -1264 R02837; HS$BCR_04. BS -1254 -1241 R02838; HS$BCR_05. BS -1220 -1210 R02839; HS$BCR_06. BS -979 -957 R02840; HS$BCR_07. BS -631 -606 R02841; HS$BCR_08. BS -555 -542 R02842; HS$BCR_09. BS -387 -372 R02843; HS$BCR_10. BS 1192 1214 R02844; HS$BCR_11. XX DR EMBL: X52828; HS5BCR. DR EMBL: Y00661; HSBCR. DR EMBL: M64437; HSBCRAA. DR EMBL: M15025; HSBCRABL. DR EMBL: M24603; HSBCRD. DR EMBL: X02596; HSBCRR. DR LOCUSLINK: 613. DR OMIM: 151410. DR REFSEQ: NM_021574. XX RN [1] RX MEDLINE; 91088292. RA Zhu Q.-S., Heisterkamp N., Groffen J. RT Unique organization of the human BCR gene promoter RL Nucleic Acids Res. 18:7119-7125 (1990). XX // AC G000213 XX ID HS$BFG XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD beta Fg XX DE beta fibrinogen XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q28 XX DR TRANSCOMPEL: C00051. DR TRANSCOMPEL: C00095. DR TRANSCOMPEL: C00110. DR LOCUSLINK: 2244. DR OMIM: 134830. DR REFSEQ: NM_005141. XX // AC G000214 XX ID HS$BAC XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD B-ACT XX DE beta-actin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 7p15-p12 XX BC 6.1.2.5.1 XX BS -1492 -1351 R00038; HS$BAC_02; Binding factors: SRF . BS -246 -52 R00039; HS$BAC_03; Binding factors: SRF . BS 688 819 R00040; HS$BAC_04; Binding factors: Elk-1 , SAP-1a BS , SRF , SAP-1b . BS 751 788 R00041; HS$BAC_05. XX DR EMBL: M10277; HSACCYBB. DR EMBL: Y00474; HSACTBPR. DR TRANSPATH: G000214. DR SMARTDB: SM0000166. DR LOCUSLINK: 60. DR OMIM: 102630. DR REFSEQ: NM_001101. XX RN [1] RX MEDLINE; 93049215. RA Treisman R., Marais R., Wynne J. RT Spatial flexibility in ternary complexes between SRF and its accessory RT proteins RL EMBO J. 11:4631-4640 (1992). RN [2] RX MEDLINE; 89098385. RA Frederickson R. M., Micheau M. R., Iwamoto A., Miyamoto N. G. RT 5' flanking and first intron sequences of the human beta-actin gene RT required for efficient promoter activity RL Nucleic Acids Res. 17:253-270 (1989). RN [3] RX MEDLINE; 88094396. RA Kawamoto T., Makino K., Niwa H., Sugiyama H., Kimura S., Amemura M., Nakata RA A., Kakunaga T. RT Identification of the Human beta-Actin Enhancer and Its Binding Factor RL Mol. Cell. Biol. 8:267-272 (1988). XX // AC G000215 XX ID HS$BG XX DT 14.06.1995 (created); dbo. DT 28.02.2002 (updated); mas. CO Copyright (C), Biobase GmbH. XX SD GLOB-B XX DE beta-globin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.5 XX BC 6.1.3.10.3 XX BS -60520 -60503 R04132; HS$BG_40; Binding factors: CP2 , CP2 BS . BS -57626 -57620 R04288; HS$BG_41; Binding factors: NF-E2 . BS -57569 -57564 R04289; HS$BG_42; Binding factors: GATA-1 . BS -57548 -57542 R04290; HS$BG_43; Binding factors: CAC-binding protein BS . BS -57526 -57522 R04291; HS$BG_44; Binding factors: CAC-binding protein BS . BS -57519 -57514 R04292; HS$BG_45; Binding factors: GATA-1 . BS -57499 -57496 R04293; HS$BG_46; Binding factors: NF-E2 . BS -57482 -57477 R04294; HS$BG_47; Binding factors: GATA-1 . BS -57450 -57446 R04295; HS$BG_48; Binding factors: CAC-binding protein BS . BS -57418 -57413 R04296; HS$BG_49; Binding factors: GATA-1 . BS -53478 -53455 R02420; HS$BG_50; Binding factors: AP-1 , c-Fos BS , c-Jun , NF-E2 , NF-E2 , MafG . BS -53410 -53402 R03491; HS$BG_51; Binding factors: GATA-1 . BS -53350 -53340 R03492; HS$BG_52. BS -549 0 R01903; HS$BG_08; Binding factors: BP1 . BS -273 -257 R01904; HS$BG_09; Binding factors: BP1 , BP2 . BS -98 -81 R00520; HS$BG_01; Binding factors: CACCC-binding factor BS . BS -89 -71 R00521; HS$BG_02; Binding factors: CTF . BS 605 625 R08236; HS$BG_24; Binding factors: GATA-1 . BS 826 875 R08237; HS$BG_25; Binding factors: POU2F1 . BS 892 923 R08238; HS$BG_26; Binding factors: POU2F1 . BS 1038 1064 R08239; HS$BG_27; Binding factors: GATA-1 . BS 1056 1064 R08240; HS$BG_28. BS 1115 1124 R08241; HS$BG_29; Binding factors: GATA-1 . BS 1212 1229 R08242; HS$BG_30. BS 1323 1341 R08243; HS$BG_31; Binding factors: GATA-1 . BS 2184 2198 R00522; HS$BG_03; Binding factors: GATA-1 . BS 2294 2310 R00523; HS$BG_04; Binding factors: GATA-1 . BS 2343 2358 R00524; HS$BG_05; Binding factors: GATA-1 . BS 2384 2399 R00525; HS$BG_06; Binding factors: GATA-1 . BS 2384 2399 R00526; HS$BG_07; Binding factors: GATA-1 . BS 8592 8606 R04083; HS$BG_14. XX DR EMBL: X00423; HSGL08. DR EMBL: J00153; HSHBA4. DR EMBL: U01317; HSHBB. DR EMBL: M34058; HSHBB221. DR EMBL: M36640; HSHBBAAZ. DR TRANSPATH: G000215. DR SMARTDB: SM0000137. DR SMARTDB: SM0000138. DR SMARTDB: SM0000139. DR SMARTDB: SM0000140. DR TRRD: 00334. DR LOCUSLINK: 3043. DR OMIM: 141900. DR REFSEQ: NM_000518. XX RN [1] RX MEDLINE; 20287401. RA Asano H., Li X. S., Stamatoyannopoulos G. RT FKLF-2: a novel Kruppel-like transcriptional factor that activates globin RT and other erythroid lineage genes RL Blood 95:3578-3584 (2000). RN [2] RX MEDLINE; 97341189. RA Marini M. G., Chan K., Casula L., Kan Y. W., Cao A., Moi P. RT hMAF, a small human transcription factor that heterodimerizes specifically RT with Nrf1 and Nrf2 RL J. Biol. Chem. 272:16490-16497 (1997). RN [3] RX MEDLINE; 96081893. RA Jackson C. E., O'Neill D., Bank A. RT Nuclear factor binding sites in human beta globin IVS2. RL J. Biol. Chem. 270:28448-28456 (1995). RN [4] RX MEDLINE; 92335187. RA Strauss E. C., Orkin S. H. RT In vivo protein-DNA interactions at hypersensitive site 3 of the human RT beta-globin locus control region RL Proc. Natl. Acad. Sci. USA 89:5809-5813 (1992). RN [5] RX MEDLINE; 93066255. RA Walters M., Martin D. I. K. RT Functional erythroid promoters created by interaction of the transcription RT factor GATA-1 with CACCC and AP-1/NFE-2 elements. RL Proc. Natl. Acad. Sci. USA 89:10444-10448 (1992). RN [6] RX MEDLINE; 91224090. RA Talbot D., Grosveld F. RT The 5'HS2 of the globin locus control region enhances transcription through RT the interaction of a multimeric complex binding at two functionally RT distinct NF-E2 binding sites RL EMBO J. 10:1391-1398 (1991). RN [7] RX MEDLINE; 92020914. RA Reddy P. M. S., Shen C.-K. J. RT Protein-DNA interactions in vivo of an erythroid-specific human beta-globin RT locus enhancer RL Proc. Natl. Acad. Sci. USA 88:8676-8680 (1991). RN [8] RX MEDLINE; 92052236. RA Ikuta T., Kan Y. W. RT In vivo protein-DNA interactions at the beta-globin gene locus RL Proc. Natl. Acad. Sci. USA 88:10188-10192 (1991). RN [9] RX MEDLINE; 92020232. RA Walters M., Kim C., Gelinas R. RT Characterization of a DNA binding activity in DNAse I hypersensitive site 4 RT of the human globin locus control region RL Nucleic Acids Res. 19:5385-5393 (1991). RN [10] RX MEDLINE; 90346297. RA Ney P. A., Sorrentino B. P., McDonagh K. T., Nienhuis A. W. RT Tandem AP-1-binding sites within the human gamma-globin dominant control RT region function as an inducible enhancer in erythroid cells RL Genes Dev. 4:993-1006 (1990). RN [11] RX MEDLINE; 90114418. RA Trainor C. D., Evans T., Felsenfeld G., Boguski M. S. RT Structure and evolution of a human erythroid transcription factor RL Nature 343:92-96 (1990). RN [12] RX MEDLINE; 91045061. RA Ney P. A., Sorrentino B. P., Lowrey Ch. H., Nienhuis A. W. RT Inducibility of the HS II enhancer depends on binding of an erythroid RT specific nuclear protein RL Nucleic Acids Res. 18:6011-6017 (1990). RN [13] RX MEDLINE; 91062407. RA Moi P., Kan Y. W. RT Synergistic enhancement of globin gene expression by activator RT protein-1-like proteins RL Proc. Natl. Acad. Sci. USA 87:9000-9004 (1990). RN [14] RX MEDLINE; 89053047. RA Wall L., deBoer E., Grosveld F. RT The human beta-globin gene 3' enhancer contains multiple binding sites for RT an erythroid-specific protein RL Genes Dev. 2:1089-1100 (1989). RN [15] RX MEDLINE; 90067848. RA Berg P. E., Williams D. M., Qian R.-L., Cohen R. B., Cao S.-X., Mittelman RA M., Schechter A. N. RT A common protein binds to two silencers 5' to the human beta-globin gene RL Nucleic Acids Res. 17:8833-8852 (1989). RN [16] RX MEDLINE; 88156920. RA Schuele R., Mueller M., Otsuka-Murakami H., Renkawitz R. RT Cooperativity of the glucocorticoid receptor and the CACCC-box binding RT factor RL Nature 332:87-90 (1988). RN [17] RX MEDLINE; 88247743. RA Mantovani R., Malgarettie N., Nicolis S., Giglioni B., Comi P., Cappelini RA N., Bertero M. T., Caligaris-Cappio F., Ottolenghi S. RT An erythroid specific nuclear factor binding to the proximal CACCC box of RT the beta-globin gene promoter RL Nucleic Acids Res. 16:4299-4313 (1988). RN [18] RX MEDLINE; 87078403. RA Jones K. A., Kadonaga J. T., Rosenfeld P. J., Kelly T. J., Tjian R. RT A cellular DNA-binding protein that activates eukaryotic transcription and RT replication RL Cell 48:79-89 (1987). XX // AC G000216 XX ID HS$B2AR XX DT 14.06.1995 (created); dbo. DT 27.05.2002 (updated); elf. CO Copyright (C), Biobase GmbH. XX SD B2AR XX DE beta2-adrenergic receptor XX SY ADRB2R; ADRBR; ADRB2; beta-2 adrenoceptor; BAR; catecholamine receptor; SY beta-2 adrenergic receptor. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 5q31-q32 XX BS -70 -37 R02906; HS$B2AR_01; Binding factors: CREB . XX DR EMBL: J02960; HSADRBRA. DR EMBL: Y00106; HSBAR. DR TRANSPATH: G000216. DR LOCUSLINK: 154. DR OMIM: 109690. DR REFSEQ: NM_000024. XX RN [1] RX MEDLINE; 91035471. RA Collins S., Altschmied J., Herbsman O., Caron M. G., Mellon P. L., RA Lefkowitz R. J. RT A cAMP response element in the beta2-adrenergic receptor gene confers RT transcriptional autoregulation by cAMP RL J. Biol. Chem. 265:19330-19335 (1990). XX // AC G000217 XX ID HS$CETS1 XX DT 21.05.1996 (created); ake. DT 21.01.2002 (updated); mas. CO Copyright (C), Biobase GmbH. XX SD c-ets-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11q23.3 XX BC 6.1.5.16 XX FA T00112; c-Ets-1. FA T01400; Ets-1 deltaVII. XX DR TRANSPATH: G000217. DR TRRD: 00065. DR LOCUSLINK: 2113. DR OMIM: 164720. DR REFSEQ: NM_005238. XX // AC G000218 XX ID HS$CFOS XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD c-fos XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 14q24.3 XX BC 6.1.5.16 XX BS empty empty R00459; HS$CFOS_02. BS empty empty R01640; HS$CFOS_15; Binding factors: PEA3 . BS empty empty R09546; HS$CFOS_21. BS empty empty R09713; HS$CFOS_27. BS -350 -338 R08485; HS$CFOS_20; Binding factors: STAT3 , STAT1 BS , STAT1 . BS -346 0 R00458; HS$CFOS_01; Binding factors: SIF . BS -343 -332 R09697; HS$CFOS_23; Binding factors: SPIN . BS -332 -293 R00460; HS$CFOS_03; Binding factors: p67 , TCF BS . BS -324 -301 R09712; HS$CFOS_26. BS -323 -293 R00461; HS$CFOS_04. BS -323 -277 R00462; HS$CFOS_05. BS -322 -296 R04046; HS$CFOS_18; Binding factors: E12 , E12 BS . BS -322 -296 R04047; HS$CFOS_19; Binding factors: C/EBPbeta , BS C/EBP . BS -322 -305 R09687; HS$CFOS_22. BS -320 -295 R00463; HS$CFOS_06; Binding factors: SRF (504 AA) . BS -320 -299 R00464; HS$CFOS_07; Binding factors: C/EBPbeta , SRF BS , SRF (504 AA) , SRE BP . BS -320 -299 R01889; HS$CFOS_16; Binding factors: MCM1 . BS -320 -297 R09705; HS$CFOS_25; Binding factors: SRF . BS -319 -313 R00465; HS$CFOS_08; Binding factors: SRF (504 AA) . BS -319 -302 R00466; HS$CFOS_09; Binding factors: ARG80 , Elk-1 BS , MCM1 , SAP-1a , SRF , SRF (504 AA) BS , TCF , YY1 , AG , DEF , TCF BS , Net , AG , AP3 , GP , SAP-1b BS . BS -315 -302 R00467; HS$CFOS_10; Binding factors: p67 . BS -315 -304 R09698; HS$CFOS_24; Binding factors: SPIN . BS -306 -292 R00468; HS$CFOS_11; Binding factors: AP-1 , ATF BS . BS -276 -227 R00469; HS$CFOS_12. BS -93 -74 R00470; HS$CFOS_13. BS -70 -50 R00471; HS$CFOS_14; Binding factors: CREB , CREB BS , CRE-BP1 , 47-kDa CRE bind. prot. , TREB-1 BS , CREB . BS 18 38 R03425; HS$CFOS_17. XX FA T00123; c-Fos. XX DR EMBL: V01512; HSCFOS. DR EMBL: M15429; HSCFOS01. DR EMBL: K00650; HSFOS. DR TRANSPATH: G000218. DR TRANSCOMPEL: C00009. DR TRANSCOMPEL: C00022. DR TRANSCOMPEL: C00270. DR TRANSCOMPEL: C00304. DR TRRD: 00110. DR LOCUSLINK: 2353. DR OMIM: 164810. DR REFSEQ: NM_005252. XX RN [1] RX MEDLINE; 21125882. RA Ehret G. B., Reichenbach P., Schindler U., Horvath C. M., Fritz S., Nabholz RA M., Bucher P. RT DNA binding specificity of different STAT proteins. Comparison of in vitro RT specificity with natural target sites. RL J. Biol. Chem. 276:6675-6688 (2001). RN [2] RX MEDLINE; 20400505. RA Bernal-Mizrachi E., Wice B., Inoue H., Permutt M. A. RT Activation of serum response factor in the depolarization induction of RT Egr-1 transcription in pancreatic islet beta-cells RL J. Biol. Chem. 275:25681-25689 (2000). RN [3] RX MEDLINE; 20471921. RA White C. M., Heidenreich O., Nordheim A., Beerman T. A. RT Evaluation of the effectiveness of DNA-binding drugs To inhibit RT transcription using the c-fos serum response element as a target RL Biochemistry 39:122262-12273 (2000). RN [4] RX MEDLINE; 99252885. RA Chaudhary J., Skinner M. K. RT Basic helix-loop-helix proteins can act at the E-box within the serum RT response element of the c-fos promoter to influence hormone-induced RT promoter activation in Sertoli cells RL Mol. Endocrinol. 13:774-786 (1999). RN [5] RX MEDLINE; 97475825. RA Grueneberg D. A., Henry R. W., Brauer A., Novina C. D., Cheriyath V., Roy RA A.L., Gilman M. RT A multifunctional DNA-binding protein that promotes the formation of serum RT response factor/homeodomain complexes: identity to TFII-I RL Genes Dev. 11:2482-2493 (1997). RN [6] RX MEDLINE; 96184854. RA Magnaghi-Jaulin L., Masutani H., Robin P., Lipinski M., Harel-Bellan A. RT SRE elements are binding sites for the fusion protein EWS-FLI-1 RL Nucleic Acids Res. 24:1052-1058 (1996). RN [7] RA Miranti C. K., Ginty D. D., Huang G., Chatila T., Greenberg M. E. RT Calcium activates serum response factor-dependent transcription by a Ras- RT and Elk-1-independent mechanism that involves a Ca2+/calmodulin- dependent RT kinase RL Mol. Cell. Biol. 15:3672-3684 (1995). RN [8] RX MEDLINE; 96067132. RA Hill C. S., Treisman R. RT Differential activation of c-fos promoter elements by serum, RT lysophosphatidic acid, G proteins and polypeptide growth factors RL EMBO J. 14:5037-5047 (1995). RN [9] RX MEDLINE; 95212535. RA Trouche D., Masutani H., Groisman R., Robin P., Lenormand J. L., RA Harel-Bellan A. RT Myogenin binds to and represses c-fos promoter RL FEBS Lett. 361:140-144 (1995). RN [10] RX MEDLINE; 94185169. RA Alberini C. M., Ghirardi M., Metz R., Kandel E. R. RT C/EBP is an immediate-early gene required for the consolidation of RT long-term facilitation in Aplysia RL Cell 76:1099-1114 (1994). RN [11] RX MEDLINE; 95047310. RA Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B. RT Net, a new ets transcription factor that is activated by Ras RL Genes Dev. 8:1502-1513 (1994). RN [12] RX MEDLINE; 94344102. RA Johansen F.-E., Prywes R. RT Two pathways for serum regulation of the c-fos serum response element RT require specific sequence elements and a minimal domain of serum response RT factor RL Mol. Cell. Biol. 14:5920-5928 (1994). RN [13] RX MEDLINE; 93238285. RA Marais R., Wynne J., Treisman R. RT The SRF accessory protein Elk-1 contains a growth factor-regulated RT transcriptional activation domain RL Cell 73:381-393 (1993). RN [14] RX MEDLINE; 93109295. RA Sharrocks A. D., Gille H., Shaw P. E. RT Identification of amino acids essential for DNA binding and dimerization in RT p67SRF: implications for a novel DNA-binding motif RL Mol. Cell. Biol. 13:123-132 (1993). RN [15] RX MEDLINE; 93227031. RA Ginty D. D., Kornhauser J. M., Thompson M. A., Bading H., Mayo K. E., RA Takahashi J. S., Greenberg M. E. RT Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light RT and a circadian clock RL Science 260:238-241 (1993). RN [16] RX MEDLINE; 93281421. RA Svinarchuk F., Mastyugin V., Gorn V., Dobrikov M., Doronin S. RT Determination of the molecular mass of the transcription factor interacting RT with FBS2 in c-fos promoter RL Nucleic Acids Res. 21:2535-2536 (1993). RN [17] RX MEDLINE; 92154673. RA Dalton S., Treisman R. RT Characterization of SAP-1, a protein recruited by serum response factor to RT the c-fos serum response element RL Cell 68:597-612 (1992). RN [18] RX MEDLINE; 93049215. RA Treisman R., Marais R., Wynne J. RT Spatial flexibility in ternary complexes between SRF and its accessory RT proteins RL EMBO J. 11:4631-4640 (1992). RN [19] RX MEDLINE; 92375089. RA Gualberto A., LePage D., Pons G., Mader S. L., Park K., Atchison M. L., RA Walsh K. RT Functional antagonism between YY1 and the serum response factor RL Mol. Cell. Biol. 12:4209-4214 (1992). RN [20] RX MEDLINE; 92350282. RA Gille H., Sharrocks A. D., Shaw P. E. RT Phosphorylation of transcription factor p62TCF by MAP kinase stimulates RT ternary complex formation at c-fos promoter RL Nature 358:414-417 (1992). RN [21] RX MEDLINE; 93024422. RA Boulden A. M., Sealy L. J. RT Maximal serum stimulation of the c-fos serum response element requires both RT the serum response factor and a novel binding factor, SRE-binding protein RL Mol. Cell. Biol. 12:4769-4783 (1992). RN [22] RX MEDLINE; 92347336. RA Shaw P. E. RT Ternary complex formation over the c-fos serum response element: p62TCF RT exhibits dual component specificity with contacts to DNA and an extended RT structure in the DNA-binding domain of p67SRF RL EMBO J. 11:3011-3019 (1992). RN [23] RX MEDLINE; 93094288. RA Lin X., Wang Z., Gu L., Deuel T. F. RT Functional analysis of the human platelet-derived growth factor A-chain RT promoter region RL J. Biol. Chem. 267:25614-25619 (1992). RN [24] RX MEDLINE; 92097542. RA Mueller C. G. F., Nordheim A. RT A protein domain conserved between yeast MCM1 and human SRF directs ternary RT complex formation RL EMBO J. 10:4219-4229 (1991). RN [25] RX MEDLINE; 92009167. RA Metz R., Ziff E. RT cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to RT trans-locate to the nucleus and induce c-fos transcription RL Genes Dev. 5:1754-1766 (1991). RN [26] RX MEDLINE; 91203896. RA de Belle I., Walker P. R., Smith I. C. P., Sikorska M. RT Identification of a multiprotein complex interacting with the c-fos serum RT response element RL Mol. Cell. Biol. 11:2752-2759 (1991). RN [27] RX MEDLINE; 92100194. RA Hipskind R. A., Rao V. N., Mueller C. G. F., Reddy E. S. P., Nordheim A. RT Ets-related protein Elk-1 is homologous to the c-fos regulatory factor RT p62TCF RL Nature 354:531-534 (1991). RN [28] RX MEDLINE; 91288203. RA Latinkic B. V., O'Brien T. P., Lau L. F. RT Promoter function and structure of the growth factor-inducible immediate RT early gene cyr61 RL Nucleic Acids Res. 19:3261 (1991). RN [29] RX MEDLINE; 91334123. RA Haertig E., Loncarevic I. F., Buescher M., Herrlich P., Rahmsdorf H. J. RT A new cAMP response element in the transcribed region of the human c-fos RT gene RL Nucleic Acids Res. 19:4153-4159 (1991). RN [30] RX MEDLINE; 92115315. RA Metz R., Ziff E. RT The helix-loop-helix protein rE12 and the C/EBP-related factor rNFIL-6 bind RT to neighboring sites within the c-fos serum response element RL Oncogene 6:2165-2178 (1991). RN [31] RX MEDLINE; 91102565. RA Graham R., Gilman M. RT Distinct protein targets for signals acting at the c-fos serum response RT element RL Science 251:189-192 (1991). RN [32] RX MEDLINE; 90214621. RA Schroeter H., Mueller C. G. F., Meese K., Nordheim A. RT Synergism in ternary complex formation between the dimeric glycoprotein RT p67SRF, polypeptide p62TCF and the c-fos serum response element RL EMBO J. 9:1123-1130 (1990). RN [33] RX MEDLINE; 91092272. RA Wagner B. J., Hayes T. E., Hoban C. J., Cochran B. H. RT The SIF binding element confers sis/PDGF inducibility onto the c-fos RT promoter RL EMBO J. 9:4477-4484 (1990). RN [34] RX MEDLINE; 90249731. RA Rivera V. M., Sheng M., Greenberg M. E. RT The inner core of the serum response element mediates both rapid induction RT and subsequent repression of c-fos transcription following serum stimulation RL Genes Dev. 4:255-268 (1990). RN [35] RX MEDLINE; 90346294. RA Manak J. R., de Bisschop N., Kris R. M., Prywes R. RT Casein kinase II enhances the DNA binding activity of serum response factor RL Genes Dev. 4:955-967 (1990). RN [36] RX MEDLINE; 90294287. RA Tuil D., Clergue N., Montarras D., Pinset Ch., Kahn A., Phan-Dinh-Tuy F. RT CC Ar GG boxes, cis-acting elements with a dual specificity: RT Muscle-specific transcriptional activation and serum responsiveness RL J. Mol. Biol. 213:677-686 (1990). RN [37] RX MEDLINE; 90205810. RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H. RT A cDNA for a human cyclic AMP response element-binding protein which is RT distinct from CREB and expressed preferentially in brain RL Mol. Cell. Biol. 10:1347-1357 (1990). RN [38] RX MEDLINE; 90291989. RA Gutman A., Wasylyk B. RT The collagenase gene promoter contains a TPA and oncogene-responsive unit RT encompassing the PEA3 and AP-1 binding sites RL EMBO J. 9:2241-2246 (1990). RN [39] RX MEDLINE; 89136003. RA Shaw P. E., Schroeter H., Nordheim A. RT The Ability of a Ternary Complex to Form Over the Serum Response Element RT Correlates with Serum Inducibility of the Human c-fos Promoter RL Cell 56:563-572 (1989). RN [40] RX MEDLINE; 90060016. RA Shaw P. E., Frasch S., Nordheim A. RT Repression of c-fos transcription is mediated through p6SRF bound to the SRE RL EMBO J. 8:2567-2574 (1989). RN [41] RX MEDLINE; 89378740. RA Passmore S., Elble R., Tye B.-K. RT A protein involved in minichromosome maintenance in yeast binds a RT transcriptional enhancer conserved in eukaryotes RL Genes Dev. 3:921-935 (1989). RN [42] RX MEDLINE; 89214111. RA Kwast-Welfeld J., Soong C.-J., Short M. L., Jungmann R. A. RT Identification of Rat Ovarian Nuclear Factors That Interact with the RT cAMP-inducible Lactate Dehydrogenase A Subunit Promoter RL J. Biol. Chem. 264:6941-6947 (1989). RN [43] RX MEDLINE; 89219044. RA Boxer L. M., Prywes R., Roeder R. G., Kedes L. RT The Sarcomeric Actin CArG-Binding Factor Is Indistinguishable from the RT c-fos Serum Response Factor RL Mol. Cell. Biol. 9:515-522 (1989). RN [44] RX MEDLINE; 89313766. RA Walsh K. RT Cross-Binding of Factors to Functionally Different Promoter Elements in RT c-fos and Skeletal Actin Genes RL Mol. Cell. Biol. 9:2191-2201 (1989). RN [45] RX MEDLINE; 89261803. RA Tan T.-H., Horikoshi M., Roeder R. G. RT Purification and Characterization of Multiple Nuclear Factors That Bind to RT the TAX-Inducible Enhancer within the Human T-Cell Leukemia Virus Long RT Terminal Repeat RL Mol. Cell. Biol. 9:1733-1745 (1989). RN [46] RX MEDLINE; 89295579. RA Herrera R. E., Shaw P. E., Nordheim A. RT Occupation of the c-fos serum response element in vivo by a multi-protein RT complex is unaltered by growth factor induction RL Nature 340:68-70 (1989). RN [47] RX MEDLINE; 89160246. RA Leung S., Miyamoto N. G. RT Point mutational analysis of the human c-fos serum response factor binding RT site RL Nucleic Acids Res. 17:1177 (1989). RN [48] RX MEDLINE; 89184588. RA Gustafson T. A., Taylor A., Kedes L. RT DNA bending is induced by a transcription factor that interacts with the RT human c-FOS and alpha-actin promoters RL Proc. Natl. Acad. Sci. USA 86:2162-2166 (1989). RN [49] RX MEDLINE; 89107989. RA Sassone-Corsi P., Visvader J., Ferland L., Mellon P. L., Verma I. M. RT Induction of proto-oncogene fos transcription through the adenylate cyclase RT pathway: characterization of a cAMP-responsive element RL Genes Dev. 2:1529-1538 (1988). RN [50] RX MEDLINE; 89196889. RA Hayes T. E., Sengupta P., Cochran B. H. RT The human c-fos serum response factor and the yeast factors GRM/PRTF have RT related DNA-binding specificities RL Genes Dev. 2:1713-1722 (1988). RN [51] RX MEDLINE; 89039849. RA Hyman S. E., Comb M., Lin Y.-S., Pearlberg J., Green M. R., Goodman H. M. RT A Common trans-Acting Factor Is Involved in Transcriptional Regulation of RT Neurotransmitter Genes by Cyclic AMP RL Mol. Cell. Biol. 8:4225-4233 (1988). RN [52] RX MEDLINE; 88302438. RA Yamamoto K. K., Gonzalez G. A., Biggs III W. H., Montminy M. R. RT Phosphorylation-induced binding and transcriptional efficacy of nuclear RT factor CREB RL Nature 334:494-498 (1988). RN [53] RX MEDLINE; 89071721. RA Visvader J., Sassone-Corsi P., Verma I. RT Two adjacent promoter elements mediate nerve growth factor activation of RT the c-fos gene and bind distinct nuclear complexes RL Proc. Natl. Acad. Sci. USA 85:9474-9478 (1988). RN [54] RX MEDLINE; 87172790. RA Greenberg M. E., Siegfried Z., Ziff E. B. RT Mutation of the c-fos gene dyad symmetry element inhibits serum RT inducibility of transcription in vivo and the nuclear regulatory factor RT binding in vitro RL Mol. Cell. Biol. 7:1217-1225 (1987). RN [55] RX MEDLINE; 88065484. RA Prywes R., Roeder R. G. RT Purification of the c-fos enhancer-binding protein RL Mol. Cell. Biol. 7:3482-3489 (1987). RN [56] RX MEDLINE; 88065485. RA Fisch T. M., Prywes R., Roeder R. G. RT c-fos Sequences Necessary for Basal Expression and Induction by Epidermal RT Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate, and the Calcium RT Ionophore RL Mol. Cell. Biol. 7:3490-3502 (1987). RN [57] RX MEDLINE; 88096559. RA Schroeter H., Shaw P. E., Nordheim A. RT Purification of intercalator-released p67, a polypeptide that interacts RT specifically with the c-fos serum response element RL Nucleic Acids Res. 15:10145-10158 (1987). RN [58] RX MEDLINE; 87147256. RA Hayes T. E., Kitchen A. M., Cochran B. H. RT Inducible binding of a factor to the c-fos regulatory region RL Proc. Natl. Acad. Sci. USA 84:1272-1276 (1987). RN [59] RX MEDLINE; 86272105. RA Treisman R. RT Identification of a protein-binding site that mediates transcriptional RT response of the c-fos gene to serum factors RL Cell 46:567-574 (1986). XX // AC G000219 XX ID HS$CJUN XX DT 14.06.1995 (created); dbo. DT 26.04.2001 (updated); dkl. CO Copyright (C), Biobase GmbH. XX SD c-jun XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1p32-p31 XX BC 6.1.5.16 XX BS -190 -183 R08483; HS$CJUN_08; Binding factors: c-Jun . BS -140 -130 R08501; HS$CJUN_09; Binding factors: NF-jun . BS -127 -106 R04915; HS$CJUN_07; Binding factors: Sp1 , Sp1 BS , Rb , Rb . BS -117 -107 R00955; HS$CJUN_01; Binding factors: Sp1 . BS -92 -86 R00956; HS$CJUN_02; Binding factors: CTF . BS -72 -63 R00957; HS$CJUN_03; Binding factors: AP-1 . BS -71 -64 R09953; HS$CJUN_12; Binding factors: c-Jun . BS -60 -49 R09147; HS$CJUN_10; Binding factors: MEF-2B . BS 62 73 R09952; HS$CJUN_11; Binding factors: SMAD-3 , SMAD-4 BS . BS 581 593 R00958; HS$CJUN_04; Binding factors: AP-2alphaA , BS AP-2alphaB . BS 657 666 R00959; HS$CJUN_05; Binding factors: AP-2alphaA , BS AP-2alphaB . BS 696 708 R00960; HS$CJUN_06; Binding factors: AP-1 . XX FA T00133; c-Jun. XX DR EMBL: X59744; HSCJUNU. DR EMBL: J04111; HSJUNA. DR EMBL: S38423; S38423. DR TRANSPATH: G000219. DR TRANSCOMPEL: C00195. DR TRRD: 00182. DR LOCUSLINK: 3725. DR OMIM: 165160. DR REFSEQ: NM_002228. XX RN [1] RX MEDLINE; 99147017. RA Wong C., Rougier-Chapman E. M., Frederick J. P., Datto M. B., Liberati N. RA T., Li J. M., Wang X. F. RT Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of RT the c-Jun promoter by transforming growth factor beta. RL Mol. Cell. Biol. 19:1821-1830 (1999). RN [2] RX MEDLINE; 95286682. RA Rozek D., Pfeifer G.P. RT In vivo protein-DNA interactions at the c-jun promoter in quiescent and RT serum-stimulated fibroblasts RL J. Cell. Biochem. 57:479-487 (1995). RN [3] RX MEDLINE; 94277042. RA Chen L. I., Nishinaka T., Kwan K., Kitabayashi I., Yokoyama K., Fu Y.-H. RA F., Gruenwald S., Chiu R. RT The retinoblastoma gene product RB stimulates Sp1-mediated transcription by RT liberating Sp1 from a negative regulator RL Mol. Cell. Biol. 14:4380-4389 (1994). RN [4] RX MEDLINE; 93348211. RA Muegge K., Vila M., Gusella G. L., Musso T., Herrlich P., Stein B., Durm S. RA K. RT Interleukin 1 induction of the c-jun promoter RL Proc. Natl. Acad. Sci. USA 90:7054-7058 (1993). RN [5] RX MEDLINE; 93360984. RA Rozek D., Pfeiffer G. P. RT In vivo protein-DNA interactions at the c-jun promoter: preformed complexes RT mediate the UV response RL Mol. Cell. Biol. 13:5490-5499 (1993). RN [6] RX MEDLINE; 92178989. RA Unlap T., Franklin C. C., Wagner F., Kraft A. S. RT Upstream regions of the c-jun promoter regulate phorbol ester-induced RT transcription in U937 leukemic cells RL Nucleic Acids Res. 20:897-902 (1992). RN [7] RX MEDLINE; 92224886. RA Brach M. A., Herrmann F., Yamada H., Bauerle P. A., Kufe D. W. RT Identification of NF-jun, a novel inducible transcription factor that RT regulates c-jun gene transcription RL EMBO J. 11:1479-1486 (1992). RN [8] RX MEDLINE; 89051877. RA Angel P., Hattori K., Smeal T., Karin M. RT The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1 RL Cell 55:875-885 (1988). XX // AC G000220 XX ID HS$CMYB XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD c-myb XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6q22-q23 XX BC 6.1.5.16 XX BS -625 -539 R04082; HS$CMYB_01; Binding factors: c-Myb . BS -185 -154 R04973; HS$CMYB_02; Binding factors: MZF-1 . BS -71 -45 R04974; HS$CMYB_03; Binding factors: MZF-1 . XX FA T00137; c-Myb. XX DR EMBL: M95584; HSMYBDBP. DR EMBL: S66422; S66422. DR TRANSPATH: G000220. DR LOCUSLINK: 4602. DR OMIM: 189990. DR REFSEQ: NM_005375. XX RN [1] RX MEDLINE; 96025988. RA Perrotti D., Melotti P., Skorski T., Casella I., Peschle C., Calabretta B. RT Overexpression of the zinc finger protein MZF1 inhibits hematopoietic RT development from embryonic stem cells: correlation with negative regulation RT of CD34 and c-myb promoter activity RL Mol. Cell. Biol. 15:6075-6087 (1995). RN [2] RX MEDLINE; 92049347. RA Nicolaides N. C., Gualdi R., Casadevall C., Manzella L., Calabretta B. RT Positive autoregulation of c-myb expression via Myb binding sites in the 5 RT flanking region of the human c-myb gene RL Mol. Cell. Biol. 11:6166-6176 (1991). XX // AC G000221 XX ID HS$CMYC XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD c-myc XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 8q24 XX BC 6.1.5.16 XX BS empty empty R01159; HS$CMYC_03; Binding factors: MIF-1 . BS empty empty R04522; HS$CMYC_16; Binding factors: CTCF . BS -2193 -2173 R02093; HS$CMYC_08. BS -1648 -1625 R04301; HS$CMYC_14; Binding factors: Pur factor . BS -1577 -1525 R02422; HS$CMYC_09; Binding factors: FBP . BS -1156 0 R08585; HS$CMYC_20; Binding factors: TCF-4 . BS -589 0 R08584; HS$CMYC_19; Binding factors: TCF-4 . BS -343 -318 R02571; HS$CMYC_10; Binding factors: AP-1 , POU2F1 BS , POU2F2 (Oct-2.1) . BS -151 -101 R04621; HS$CMYC_17; Binding factors: MAZ , Sp1 BS , MAZi , hnRNP K , CNBP . BS -142 -115 R01804; HS$CMYC_04; Binding factors: PuF . BS -86 -63 R04076; HS$CMYC_12. BS -76 -67 R04121; HS$CMYC_13. BS -65 -58 R01851; HS$CMYC_05; Binding factors: E2F . BS -50 -42 R08503; HS$CMYC_18; Binding factors: MAZ , Sp1 BS . BS -42 -35 R01852; HS$CMYC_06; Binding factors: E2F . BS -38 -8 R03048; HS$CMYC_11; Binding factors: MBP-1 (2) . BS 5 45 R04520; HS$CMYC_15; Binding factors: CTCF . BS 135 155 R01916; HS$CMYC_07; Binding factors: c-Myc . BS 600 622 R01157; HS$CMYC_01; Binding factors: AP-2alphaA , BS AP-2alphaB . BS 644 666 R01158; HS$CMYC_02; Binding factors: AP-2alphaA , BS AP-2alphaB , AP-2beta . XX FA T00140; c-Myc. XX DR EMBL: X00247; HSMYC2. DR EMBL: K03015; HSMYCAWT. DR EMBL: M16261; HSMYCB1. DR EMBL: K01708; HSMYCBL2. DR EMBL: M12027; HSMYCBLK. DR EMBL: M12026; HSMYCBLN. DR EMBL: X00364; HSMYCC. DR EMBL: J00120; HSMYCC1. DR EMBL: X00196; HSMYCE12. DR EMBL: K00559; HSMYCF1. DR EMBL: L00057; HSMYCG2. DR EMBL: K01909; HSMYCJB. DR EMBL: D10493; HSMYCKOB. DR EMBL: X13184; HSMYCORI. DR EMBL: M13930; HSMYCPOB. DR EMBL: M22633; HSRCMYC1. DR TRANSPATH: G000221. DR SMARTDB: SM0000114. DR TRRD: 00191. DR LOCUSLINK: 4609. DR OMIM: 190080. DR REFSEQ: NM_002467. XX RN [1] RX MEDLINE; 98397323. RA He T.-C., Sparks A. B., Rago C., Hermeking H., Zawel L., da Costa L. T., RA Morin P. J., Vogelstein B., Kinzler K. W. RT Identification of c-MYC as a target of the APC pathway RL Science 281:1509-1512 (1998). RN [2] RX MEDLINE; 96220465. RA Filippova G. N., Fagerlie S., Klenova E. M., Meyers C., Dehner Y., Goodwin RA G., Neiman P. E., Collins S. J., Lobanenkov V. V. RT An exceptionally conserved transcriptional repressor, CTCF, employs RT different combinations of zinc fingers to bind diverged promoter sequences RT of avian and mammalian c-myc oncogenes RL Mol. Cell. Biol. 16:2802-2813 (1996). RN [3] RX MEDLINE; 96428591. RA Tsutsui H., Sakatsume O., Itakura K., Yokoyama K. K. RT Members of the MAZ family: a novel cDNA clone for MAZ from human pancreatic RT islet cells RL Biochem. Biophys. Res. Commun. 226:801-809 (1996). RN [4] RX MEDLINE; 96220449. RA Michelotti G. A., Michelotti E. F., Pullner A., Duncan R. C., Eick D., RA Levens D. RT Multiple single-stranded cis elements are associated with activated RT chromatin of the human c-myc gene in vivo RL Mol. Cell. Biol. 16:2656-2669 (1996). RN [5] RX MEDLINE; 96038090. RA Moser M., Imhof A., Pscherer A., Bauer R., Amselgruber W., Sinowatz F., RA Schule R., Buettner R. RT Cloning and characterization of a second AP-2 transcription factor: AP-2 RT beta RL Development 121:2779-2788 (1995). RN [6] RX MEDLINE; 95181489. RA Tomonaga T., Levens D. RT Heterogenous nuclear ribonucleoprotein K is a DNA-binding transactivator RL J. Biol. Chem. 270:4875-4881 (1995). RN [7] RX MEDLINE; 95238469. RA Michelotti E. F., Tomonaga T., Krutzsch H., Levens D. RT Cellular nucleic acid binding protein regulates the CT element of the human RT c-myc protooncogene RL J. Biol. Chem. 270:9494-9499 (1995). RN [8] RX MEDLINE; 95229644. RA Bazar L., Meighen D., Harris V., Duncan R., Levens D., Avigan M. RT Targeted melting and binding of a DNA regulatory element by a RT transactivator of c-myc RL J. Biol. Chem. 270:8241-8248 (1995). RN [9] RX MEDLINE; 94170991. RA Duncan R., Bazar L., Michelotti G., Tomonaga T., Krutzsch H., Avigan M., RA Levens D. RT A sequence-specific, single-strand binding protein activates the far RT upstream element of c-myc and defines a new DNA-binding motif RL Genes Dev. 8:465-480 (1994). RN [10] RX MEDLINE; 93324921. RA Postel E. H., Berberich S. J., Flint S. J., Ferrone C. A. RT Human c-myc transcription factor PuF identified as nm23-H2 nucleoside RT diphospate kinase, a candidate suppressor of tumor metastasis RL Science 261:478-480 (1993). RN [11] RX MEDLINE; 93352650. RA Takimoto M., Tomonaga T., Matunis M., Avigan M., Krutzsch H., Dreyfuss G., RA Levens D. RT Specific binding of heterogeneous ribonucleoprotein particle protein K to RT the human c-myc promoter, in vitro RL J. Biol. Chem. 268:18249-18258 (1993). RN [12] RX MEDLINE; 93361005. RA DesJardins E., Hay N. RT Repeated CT elements bound by zinc finger proteins control the absolute and RT relative activities of the two principal human c-myc promoters RL Mol. Cell. Biol. 13:5710-5724 (1993). RN [13] RX MEDLINE; 91172204. RA Ray R., Miller D. M. RT Cloning and characterization of a human c-myc promoter-binding protein RL Mol. Cell. Biol. 11:2154-2161 (1991). RN [14] RX MEDLINE; 91149081. RA Saksela K., Koskinen P. J., Alitalo K. RT Binding of a nuclear factor to the upstream region of the c-myc gene RL Oncogene Res. 6:73-76 (1991). RN [15] RX MEDLINE; 92052244. RA Pietenpol J. A., Muenger K., Howley P. M., Stein R. W., Moses H. L. RT Factor-binding element in the human c-myc promoter involved in RT transcriptional regulation by transforming growth factor beta1 and by the RT retinoblastoma gene product RL Proc. Natl. Acad. Sci. USA 88:10227-10231 (1991). RN [16] RX MEDLINE; 91348027. RA Turpaev K. T., Itkes A. V., Alexandrova N. M., Pokrovskaya O. V., Imamova RA L. R., Chernov B. K., Kisselev L. L. RT Binding of proteins of HeLa S3 cell extract to oligonucleotides containing RT the consensus interferon-response sequence (IRS) and to the IRS-containing RT fragment of the human c-myc gene RL Eur. J. Biochem. 200:107-111 (1991). RN [17] RX MEDLINE; 90170963. RA Zajac-Kaye M., Levens D. RT Phosphorylation-dependent Binding of a 138-kDa myc Intron Factor to a RT Regulatory Element in the First Intron of the c-myc Gene RL J. Biol. Chem. 265:4547-4551 (1990). RN [18] RX MEDLINE; 91009354. RA Avigan M. I., Strober B., Levens D. RT A far upstream element stimulates c-myc expression in undifferentiated RT leukemia cells RL J. Biol. Chem. 265:18538-18545 (1990). RN [19] RX MEDLINE; 90076150. RA Ariga H., Imamura Y., Iguchi-Ariga S. M. M. RT DNA replication origin and transcriptional enhancer in c-myc gene share the RT c-myc protein binding sequences RL EMBO J. 8:4273-4279 (1989). RN [20] RX MEDLINE; 89252808. RA Hay N., Takimoto M., Bishop J. M. RT A FOS protein is present in a complex that binds a negative regulator of MYC RL Genes Dev. 3:293-303 (1989). RN [21] RX MEDLINE; 89252827. RA Thalmeier K., Synovzik H., Mertz R., Winnacker E.-L., Lipp M. RT Nuclear factor E2F mediates basic transcription and trans-activation by E1a RT of the human MYC promoter RL Genes Dev. 3:527-536 (1989). RN [22] RX MEDLINE; 89255374. RA Takimoto M., Quinn J. P., Farina A. R., Staudt L. M., Levens D. RT fos/jun and Octamer-binding Protein Interact with a Common Site in a RT Negative Element of the Human c-myc Gene RL J. Biol. Chem. 264:8982-8999 (1989). RN [23] RX MEDLINE; 90097929. RA Postel E. H., Mango S. E., Flint S. J. RT A Nuclease-Hypersensitive Element of the Human c-myc Promoter Interacts RT with a Transcription Initiation Factor RL Mol. Cell. Biol. 9:5123-5133 (1989). RN [24] RX MEDLINE; 89264470. RA Hiebert S. W., Lipp M., Nevins J. R. RT E1A-dependent trans-activation of the human MYC promoter is mediated by the RT E2F factor RL Proc. Natl. Acad. Sci. USA 86:3594-3598 (1989). RN [25] RX MEDLINE; 90099328. RA Davis T. L., Firulli A. B., Kinniburgh A. J. RT Ribonucleoprotein and protein factors bind to an H-DNA-forming c-myc DNA RT element: possible regulators of the c-myc gene RL Proc. Natl. Acad. Sci. USA 86:9682-9686 (1989). RN [26] RX MEDLINE; 88027009. RA Imagawa M., Chiu R., Karin M. RT Transcription factor AP-2 mediates induction by two different signal RT transduction pathways: Protein kinase C and cAMP RL Cell 51:251-260 (1987). XX // AC G000222 XX ID HS$CANP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CANP XX DE calcium-dependent protease XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.4.7 XX BS -230 0 R02643; HS$CANP_01; Binding factors: GCF . XX DR EMBL: J04700; HSCANPRA. DR TRANSPATH: G000222. DR BRENDA: 3.4.22.17; Human. XX RN [1] RX MEDLINE; 90075226. RA Kageyama R., Pastan I. RT Molecular Cloning and Characterization of a Human DNA Binding Factor That RT Represses Transcription RL Cell 59:815-825 (1989). XX // AC G000223 XX ID HS$CD19 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CD19 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 16p11.2 XX BC 6.1.6.5.4 XX BS -147 -124 R04286; HS$CD19_02; Binding factors: Pax-5 , Pax-6 BS , Pax-2.1 , Pax-2.2 , Pax-9a , Pax-9b BS . BS -86 -61 R04285; HS$CD19_01; Binding factors: Pax-5 , Pax-6 BS , Pax-2.1 , Pax-2.2 , Pax-9a , Pax-9b BS . XX DR EMBL: M62544; HSCD1904. DR EMBL: M84371; HSCD19A. DR TRANSPATH: G000223. DR LOCUSLINK: 930. DR OMIM: 107265. DR REFSEQ: NM_001770. XX RN [1] RX MEDLINE; 98337825. RA Lun K., Brand M. RT A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals RT multiple signaling events in development of the midbrain-hindbrain boundary RL Development 125:3049-3062 (1998). RN [2] RX MEDLINE; 97059146. RA Nornes S., Mikkola I., Krauss S., Delghandi M., Perander M., Johansen T. RT Zebrafish Pax9 encodes two proteins with distinct C-terminal RT transactivating domains of different potency negatively regulated by RT adjacent N-terminal sequences RL J. Biol. Chem. 271:26914-26923 (1996). RN [3] RX MEDLINE; 92269839. RA Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M. RT The promoter of the CD19 gene is a target for the B-cell-specific RT transcription factor BSAP RL Mol. Cell. Biol. 12:2662-2672 (1992). XX // AC G000224 XX ID HS$CD2 XX DT 14.06.1995 (created); dbo. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CD2 XX SY SRBC; T11. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1p13 XX BC 6.1.6.5.4 XX BS 32 41 R02752; HS$CD2_01. BS 120 132 R02753; HS$CD2_02. BS 218 229 R02754; HS$CD2_03. BS 315 335 R02755; HS$CD2_04. BS 510 535 R02756; HS$CD2_05. BS 541 549 R02757; HS$CD2_06. XX DR EMBL: X55006; HSENHCD2. DR LOCUSLINK: 914. DR OMIM: 186990. DR REFSEQ: NM_001767. XX RN [1] RX MEDLINE; 91006005. RA Lake R. A., Wotton D., Owen M. J. RT A 3' transcriptional enhancer regulates tissue-specific expression of the RT human CD2 gene RL EMBO J. 9:3129-3136 (1990). XX // AC G000225 XX ID HS$CD3E XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CD3-epsilon XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11q23 XX BC 6.1.6.5.4 XX BS empty empty R03576; HS$CD3E_01; Binding factors: LEF-1 , SRY BS , TCF-1A , TCF-1B , TCF-1C , TCF-1 BS , mat1-Mc , Sox-5 , TCF-1E , TCF-1F BS , TCF-1G , Sox-13 . BS empty empty R04297; HS$CD3E_02; Binding factors: SRY , TCF-1A BS . XX DR TRANSPATH: G000225. DR LOCUSLINK: 916. DR OMIM: 186830. DR REFSEQ: NM_000733. XX RN [1] RX MEDLINE; 98083175. RA Roose J., Korver W., Oving E., Wilson A., Wagenaar G., Markman M., Lamers RA W., Clevers H. RT High expression of the HMG box factor Sox-13 in arterial walls during RT embryonic development RL Nucleic Acids Res. 26:469-476 (1998). RN [2] RX MEDLINE; 94043341. RA Dooijes D., van de Wetering M., Knippels L., Clevers H. RT The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a RT sequence-specific DNA-binding high mobility group box protein RL J. Biol. Chem. 268:24813-24817 (1993). RN [3] RX MEDLINE; 92132550. RA Harley V. R., Jackson D. I., Hextall P. J., Hawkins J. R., Berkovitz G. D., RA Sockanathan S., Lovell-Badge R., Goodfellow P. N. RT DNA binding activity of recombinant SRY from normal males and XY females RL Science 255:453-456 (1992). RN [4] RX MEDLINE; 93010962. RA Denny P., Swift S., Connor F., Ashworth A. RT An SRY-related gene expressed during spermatogenesis in the mouse encodes a RT sequence-specific DNA-binding protein RL EMBO J. 11:3705-3712 (1992). RN [5] RX MEDLINE; 92347339. RA van de Wetering M., Clevers H. RT Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs RT within the minor groove of a Watson-Crick double helix RL EMBO J. 11:3039-3044 (1992). RN [6] RX MEDLINE; 91114695. RA van de Wetering M., Oosterwegel M., Dooijes D., Clevers H. RT Identification and cloning of TCF-1, a T lymphocyte-specific transcription RT factor containing a sequence-specific HMG box RL EMBO J. 10:123-132 (1991). XX // AC G000226 XX ID HS$CGB XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD CGbeta XX DE chorionic gonadotropin beta-subunit XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.5.3.1 XX BS -300 -291 R04038; HS$CGB_01. BS -287 274 R04039; HS$CGB_02. BS -240 -216 R04040; HS$CGB_03. BS -153 -147 R04041; HS$CGB_04. BS -143 -130 R04042; HS$CGB_05. BS -117 -100 R04043; HS$CGB_06. XX DR EMBL: M13504; HSCG3B. DR EMBL: M13503; HSCG7B2. XX RN [1] RX MEDLINE; 91304434. RA Albanese C., Kay T. W. H., Troccoli N. M., Jameson J. L. RT Novel cyclic adenosine 3',5'-monophosphate response element in the human RT chorionic gonadotropin beta-subunit gene RL Mol. Endocrinol. 5:693-702 (1991). XX // AC G000227 XX ID HS$M1A XX DT 21.05.1996 (created); ake. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HLA-A XX DE MHC class I human leukocyte antigen A XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.6.5.3.1 XX DR TRRD: 00186. DR LOCUSLINK: 3105. DR OMIM: 142800. DR REFSEQ: NM_002116. XX // AC G000228 XX ID HS$M1B XX DT 21.05.1996 (created); ake. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HLA-B XX DE MHC class I human leukocyte antigen B XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.6.5.3.1 XX DR TRRD: 00187. DR LOCUSLINK: 3106. DR OMIM: 142830. DR REFSEQ: NM_005514. XX // AC G000229 XX ID HS$MMP1 XX DT 14.06.1995 (created); dbo. DT 27.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD MMP1 XX DE matrix metalloproteinase 1 XX SY CN2; collagenase I; interstitial collagenase; CLG; fibroblast collagenase. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11q21-q22 XX BC 6.1.4.7.3 XX BS empty empty R09937; HS$CLASE_06; Binding factors: SMAD-3 , BS SMAD-4 . BS -320 -306 R12654; HS$MMP1_01; Binding factors: CIZ8 , CIZ6-1 BS . BS -167 -161 R03527; HS$CLASE_03. BS -133 -129 R03528; HS$CLASE_04. BS -89 -83 R01639; HS$CLASE_02; Binding factors: PEA3 . BS -79 -60 R00235; HS$CLASE_01; Binding factors: AP-1 , c-Fos BS , c-Jun , pap1 , v-Jun , CREB , BS deltaCREB . BS -72 -66 R09882; HS$CLASE_08; Binding factors: c-Jun . BS -66 -63 R09881; HS$CLASE_07; Binding factors: SMAD-3 . BS -56 0 R03529; HS$CLASE_05. XX DR EMBL: AF023338; AF023338. DR EMBL: M16567; HSCN2A. DR TRANSPATH: G000229. DR TRANSCOMPEL: C00083. DR TRANSCOMPEL: C00242. DR TRRD: 00062. DR LOCUSLINK: 4312. DR OMIM: 120353. DR REFSEQ: NM_002421. XX RN [1] RX MEDLINE; 10995748. RA Qing J., Zhang Y., Derynck R. RT Structural and functional characterization of the transforming growth RT factor-beta -induced Smad3/c-Jun transcriptional cooperativity RL J. Biol. Chem. 275:38802-38812 (2000). RN [2] RX MEDLINE; 20136045. RA Nakamoto T., Yamagata T., Sakai R., Ogawa S., Honda H., Ueno H., Hirano N., RA Yazaki Y., Hirai H. RT CIZ, a zinc finger protein that interacts with p130(cas) and activates the RT expression of matrix metalloproteinases RL Mol. Cell. Biol. 20:1649-1658 (2000). RN [3] RX MEDLINE; 9372933. RA Yingling J. M., Datto M. B., Wong C., Frederick J. P., Liberati N.T., Wang RA X. F. RT Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA RT binding protein. RL Mol. Cell. Biol. 17:7019-7018 (1997). RN [4] RX MEDLINE; 92289689. RA Koenig H., Ponta H., Rahmsdorf H. J., Herrlich P. RT Interference between pathway-specific transcription factors: RT glucocorticoids antagonize phorbol ester-induced AP-1 activity without RT altering AP-1 site occupation in vivo RL EMBO J. 11:2241-2246 (1992). RN [5] RX MEDLINE; 91309144. RA Kerppola T. K., Curran T. RT Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: RT implications for transcription factor cooperativity RL Cell 66:317-326 (1991). RN [6] RX MEDLINE; 91216102. RA Kramer I. M., Koornneef I., de Laat S. W., van den Eijnden-van Raaij A. J. RA M. RT TGF-beta1 induces phosphorylation of the cyclic AMP responsive element RT binding protein in ML-CCI64 cells RL EMBO J. 10:1083-1089 (1991). RN [7] RX MEDLINE; 91115099. RA Toda T., Shimanuki M., Yanagida M. RT Fission yeast gene that confer resistance to staurosporine encode an RT AP-1-like transcription factor and a protein kinase related to the RT mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases RL Genes Dev. 5:60-73 (1991). RN [8] RX MEDLINE; 92049330. RA Zhang X.-K., Wills K. N., Husman M., Hermann T., Pfahl M. RT Novel pathway for thyroid hormone receptor action through interaction with RT jun and fos oncogene activities RL Mol. Cell. Biol. 11:6016-6025 (1991). RN [9] RX MEDLINE; 92020119. RA Jang K. L., Pulverer B., Woodgett J., Latchman D. S. RT Activation of the cellular transcription factor AP-1 in herpes simplex RT virus infected cells is dependent on the viral immediate-early protein ICPO RL Nucleic Acids Res. 19:4879-4883 (1991). RN [10] RX MEDLINE; 91296767. RA Schuele R., Rangarajan P., Yang N., Kliewer S., Ransone L. J., Bolado J., RA Verma I. M., Evans R. M. RT Retinoic acid is a negative regulator of AP-1-responsive genes RL Proc. Natl. Acad. Sci. USA 88:6092-6096 (1991). RN [11] RX MEDLINE; 90235276. RA Kerr L. D., Miller D. B., Matrisian L. M. RT TGF-beta1 inhibition of transin/stromelysin gene expression is mediated RT through a fos binding sequence RL Cell 61:267-278 (1990). RN [12] RX MEDLINE; 90381775. RA Jonat C., Rahmsdorf H. J., Park K.-K., Cato A. C. B., Gebel S., Ponta H., RA Herrlich P. RT Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) RT activity by glucocorticoid hormone RL Cell 62:1189-1204 (1990). RN [13] RX MEDLINE; 90174947. RA Timmers H. T. M., Pronk G. J., Bos J. L., van der Eb A. J. RT Analysis of the rat JE gene promoter identifies an AP-1 binding site RT essential for basal expression but not for TPA induction RL Nucleic Acids Res. 18:23-34 (1990). RN [14] RX MEDLINE; 90291989. RA Gutman A., Wasylyk B. RT The collagenase gene promoter contains a TPA and oncogene-responsive unit RT encompassing the PEA3 and AP-1 binding sites RL EMBO J. 9:2241-2246 (1990). RN [15] RX MEDLINE; 90152343. RA Mueller U., Roberts M. P., Engel D. A., Doerfler W., Shenk T. RT Induction of transcription factor AP-1 by adenovirus E1A protein and cAMP RL Genes Dev. 3:1991-2002 (1989). RN [16] RX MEDLINE; 90097934. RA Stein B., Rahmsdorf H. J., Steffen A., Litfin M., Herrlich P. RT UV-Induced DNA Damage Is an Intermediate Step in UV-Induced Expression of RT Human Immunodeficiency Virus Type 1 Collagenase, c-fos and Metallothionein RL Mol. Cell. Biol. 9:5169-5181 (1989). RN [17] RX MEDLINE; 89384902. RA Neuberg M., Adamkiewicz J., Hunter J. B., Mueller R. RT A Fos protein containing the leucine zipper forms a homodimer which binds RT to the AP1 binding site RL Nature 341:243-245 (1989). RN [18] RX MEDLINE; 88156935. RA Angel P., Allegretto E. A., Okino S. T., Hattori K., Boyle W. J., Hunter RA T., Karin M. RT Oncogene jun encodes a sequence-specific trans-activator similar to AP-1 RL Nature 332:166-171 (1988). RN [19] RX MEDLINE; 87215937. RA Angel P., Imagawa M., Chiu R., Stein B., Imbra R. J., Rahmsdorf H. J., RA Jonat C., Herrlich P., Karin M. RT Phorbol ester-inducible genes contain a common cis element recognized by a RT TPA-modulated trans-acting factor RL Cell 49:729-739 (1987). XX // AC G000230 XX ID HS$CC3 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD C3 XX DE complement C3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 19p13.3-p13.2 XX BC 6.1.6.6 XX BS -133 -95 R02468; HS$CC3_01; Binding factors: C/EBPalpha , Il-1 BS RF , Il-6 RF . BS -89 -83 R02469; HS$CC3_02. XX DR EMBL: K02765; HSC3. DR EMBL: M55658; HSCD3AA. DR EMBL: M63423; HSCS5P. DR TRANSPATH: G000230. DR TRRD: 00111. DR LOCUSLINK: 718. DR OMIM: 120700. DR REFSEQ: NM_000064. XX RN [1] RX MEDLINE; 91061724. RA Wilson D. R., Juan T. S.-C., Wilde M. D., Fey G. H., Darlington G. J. RT A 58-base-pair region of the human C3 gene confers synergistic inducibility RT by interleukin-1 and interleukin-6 RL Mol. Cell. Biol. 10:6181-6191 (1990). RN [2] RX MEDLINE; 91061727. RA Kikkawa F., Gonzalez F. J., Kimura S. RT Characterization of a thyroid-specific enhancer located 5.5 kilobase pairs RT upstream of the human thyroid peroxidase gene RL Mol. Cell. Biol. 10:6216-6224 (1990). XX // AC G000231 XX ID HS$CBF XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Bf XX DE complement factor B XX SY Ba. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.4.7.1 XX BS -143 -126 R00423; HS$CBF_01; Binding factors: ICSBP . XX DR EMBL: M15082; HSMHBA1. DR TRANSPATH: G000231. DR TRRD: 00341. DR LOCUSLINK: 629. DR OMIM: 138470. DR REFSEQ: NM_001710. XX RN [1] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [2] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). XX // AC G000232 XX ID HS$CREBP1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CRE-BP1 XX DE CRE-binding protein 1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 2q32 XX BC 6.1.2.2 XX BS -551 -535 R02423; HS$CREBP1_01; Binding factors: Sp1 . BS -526 -507 R02424; HS$CREBP1_02; Binding factors: Sp1 . BS -486 -466 R02425; HS$CREBP1_03; Binding factors: AP-2alphaA , BS AP-2alphaB . BS -464 -443 R02426; HS$CREBP1_04; Binding factors: Sp1 . BS -408 -386 R02427; HS$CREBP1_05; Binding factors: CRE-BP1 . BS -380 -361 R02428; HS$CREBP1_06; Binding factors: Sp1 . BS -354 -333 R02429; HS$CREBP1_07. BS -300 -283 R02430; HS$CREBP1_08. BS -244 -216 R02431; HS$CREBP1_09. BS -184 -162 R02432; HS$CREBP1_10; Binding factors: Sp1 . BS -160 -143 R02433; HS$CREBP1_11; Binding factors: Sp1 . BS -141 -113 R02434; HS$CREBP1_12. BS -108 -86 R02435; HS$CREBP1_13; Binding factors: Sp1 . BS -81 -59 R02436; HS$CREBP1_14; Binding factors: Sp1 . BS -55 -38 R02437; HS$CREBP1_15; Binding factors: CRE-BP1 . BS -7 9 R02438; HS$CREBP1_16; Binding factors: Sp1 . BS 10 27 R02439; HS$CREBP1_17; Binding factors: Sp1 . BS 58 78 R02440; HS$CREBP1_18; Binding factors: Sp1 . XX FA T00167; CRE-BP1. XX DR EMBL: J05623; HSCREB02. DR TRANSPATH: G000232. DR LOCUSLINK: 1386. DR OMIM: 123811. DR REFSEQ: NM_001880. XX RN [1] RX MEDLINE; 91009166. RA Nagase T., Sudo T., Maekawa T., Yoshimura T., Fujisawa J.-I., Yoshida M., RA Ishii Sh. RT Promoter region of the human CRE-BP1 gene encoding the transcriptional RT regulator binding to the cyclic AMP response element RL J. Biol. Chem. 265:17300-17306 (1990). XX // AC G000233 XX ID HS$CRP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CRP XX DE C-reactive protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1q21-q23 XX BC 6.1.3.4 XX BS -175 -133 R00237; HS$CRP_01; Binding factors: HNF-1A , HNF-1B BS , HNF-1C . BS -80 -57 R00238; HS$CRP_02; Binding factors: C/EBPbeta , HNF-1A BS , HNF-1B , HNF-1C . BS -55 -37 R00239; HS$CRP_03; Binding factors: C/EBPalpha , BS C/EBPdelta , C/EBPbeta . XX DR EMBL: M11880; HSCRPG. DR TRANSPATH: G000233. DR TRANSCOMPEL: C00045. DR TRANSCOMPEL: C00321. DR TRRD: 00339. DR LOCUSLINK: 1401. DR OMIM: 123260. DR REFSEQ: NM_000567. XX RN [1] RX MEDLINE; 93181204. RA Ramji D. P., Vitelli A., Tronche F., Cortese R., Ciliberto G. RT The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are RT induced by IL-6 to promote acute phase gene transcription via different RT mechanisms RL Nucleic Acids Res. 21:289-294 (1993). RN [2] RX MEDLINE; 91029495. RA Poli V., Mancini F. P., Cortese R. RT IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, RT defines a new family of leucine zipper proteins related to C/EBP RL Cell 63:643-653 (1990). RN [3] RX MEDLINE; 90151621. RA Majello B., Arcone R., Toniatti C., Ciliberto G. RT Constitutive and IL-6-induced nuclear factors that interact with the human RT C-reactive protein promoter RL EMBO J. 9:457-465 (1990). RN [4] RX MEDLINE; 91092271. RA Toniatti C., Demartis A., Monaci P., Nocosia A., Ciliberto G. RT Synergistic trans-activation of the human C-reactive protein promoter by RT transcription factor HNF-1 binding at two distinct sites RL EMBO J. 9:4467-4475 (1990). XX // AC G000234 XX ID HS$CS1 XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CS-1 XX DE chorionic somatomammotropin XX SY CSH1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17 XX BC 6.1.5.3.2 XX BS -134 -106 R03189; HS$CS1_01; Binding factors: Sp1 , Sp1 BS . BS -134 -106 R03190; HS$CS1_02; Binding factors: POU1F1a . BS -96 -70 R03191; HS$CS1_03; Binding factors: POU1F1a . BS -65 -33 R03192; HS$CS1_04; Binding factors: T3R . XX DR EMBL: K02401; HSCS1. DR TRANSPATH: G000234. DR TRRD: 00390. DR LOCUSLINK: 94492. XX RN [1] RX MEDLINE; 91236760. RA Tansey W. P., Catanzaro D. F. RT Sp1 and thyroid hormone receptor differentially activate expression of RT human growth hormone and chorionic somatomammotropin genes RL J. Biol. Chem. 266:9805-9813 (1991). XX // AC G000235 XX ID HS$CSB XX DT 14.06.1995 (created); dbo. DT 03.12.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CS-B XX DE placental lactogen, chorionic somatomammotropin, hCS-2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.5.3.2 XX BS -141 -117 R03957; HS$CSB_03; Binding factors: Sp1 . BS -95 -68 R03955; HS$CSB_01; Binding factors: POU1F1a . BS -67 -41 R03956; HS$CSB_02; Binding factors: T3R , T3R-alpha BS . XX DR EMBL: J00289; HSPLA. DR TRANSPATH: G000235. DR TRRD: 00084. XX RN [1] RX MEDLINE; 91302376. RA Voz M. L., Peers B., Belayew A., Martial J. A. RT Characterization of an unusual thyroid response unit in the promoter of the RT human placental lactogen gene RL J. Biol. Chem. 266:13397-13408 (1991). XX // AC G000236 XX ID HS$CT XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CT XX DE calcitonin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.5.1 XX DR TRANSCOMPEL: C00033. XX // AC G000237 XX ID HS$CYP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CYP21B XX DE cytochrome P-450C21; steroid 21-hydroxylase XX SY P450c21B; P450c21; CYP21. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.4.9.1 XX BS -250 -225 R02716; HS$CYP_01. BS -129 -96 R04429; HS$CYP_03; Binding factors: Pbx-1b . BS -124 -115 R02717; HS$CYP_02; Binding factors: Sp1 , ASP BS . XX DR EMBL: M13936; HSMHCP52. DR TRANSPATH: G000237. DR BRENDA: 1.14.99.10. DR LOCUSLINK: 1589. DR OMIM: 201910. DR REFSEQ: NM_000500. XX RN [1] RX MEDLINE; 96029608. RA Ogo A., Waterman M. R., Kamps M. P., Kagawa N. RT Protein kinase A-dependent transactivation by the E2A-Pbx1fusion protein RL J. Biol. Chem. 270:25340-25343 (1995). RN [2] RX MEDLINE; 91250433. RA Kagawa N., Waterman M. R. RT Evidence that an adrenal-specific nuclear protein regulates the cAMP RT responsiveness of the human CYP21B (P450C21) gene RL J. Biol. Chem. 266:11199-11204 (1991). RN [3] RX MEDLINE; 90293079. RA Kagawa N., Waterman M. R. RT cAMP-dependent Transcription of the Human CYP21B (P-450c21) Gene Requires a RT Cis-regulatory Element Distinct from the Consensus cAMP-regulatory Element RL J. Biol. Chem. 265:11299-11305 (1990). XX // AC G000238 XX ID HS$CYC1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CYC1 XX DE cytochrome C1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 8q24 XX BC 6.1.3.1.1 XX BS -1405 -1252 R02997; HS$CYC1_01. BS -92 -75 R09627; HS$CYC1_02; Binding factors: E2F-1 . BS -53 -37 R09628; HS$CYC1_03; Binding factors: E2F-1 . XX DR EMBL: J04444; HSCYC1A. DR TRANSPATH: G000238. DR LOCUSLINK: 1537. DR OMIM: 123980. DR REFSEQ: NM_001916. XX RN [1] RX MEDLINE; 10998368. RA Luciakova K., Barath P., Li R., Zaid A., Nelson B. D. RT Activity of the human cytochrome c1 promoter is modulated by E2F RL Biochem. J. 351:251-256 (2000). RN [2] RX MEDLINE; 91115851. RA Suzuki H., Hosokawa Y., Nishikimi M., Ozawa T. RT Existence of common homologous elements in the transcriptional regulatory RT regions of human nuclear genes abd mitochondrial gene for the oxidative RT phosphorylation system RL J. Biol. Chem. 266:2333-2338 (1991). XX // AC G000239 XX ID HS$P450AR XX DT 21.05.1996 (created); ake. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD P-450arom XX DE cytochrome P-450, aromatase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 15q21 XX BC 6.1.4.9.1 XX BS -2141 -2115 R04504; HS$P450AR_01; Binding factors: C/EBPbeta . XX DR TRANSPATH: G000239. DR BRENDA: 1.14.14.1. DR TRRD: 00152. DR LOCUSLINK: 1588. DR OMIM: 107910. DR REFSEQ: NM_031226. XX RN [1] RX MEDLINE; 95361850. RA Toda K., Akira S., Kishimoto T., Sasaki H., Hashimoto K., Yamamoto Y., RA Sagara Y., Shizuta Y. RT Identification of a transcriptional regulatory factor for human aromatase RT cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a RT member of the CCAAT/enhancer-binding protein family RL Eur. J. Biochem. 231:292-299 (1995). XX // AC G000240 XX ID HS$DG XX DT 14.06.1995 (created); dbo. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-D XX DE delta-globin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.5 XX BC 6.1.3.10.3 XX BS -1189 -1181 R03487; HS$DG_02; Binding factors: GATA-1 . BS -967 -958 R03488; HS$DG_03. BS -90 -61 R02889; HS$DG_01; Binding factors: GATA-1 . XX DR EMBL: V00505; HSDGL1. DR EMBL: U01317; HSHBB. DR TRANSPATH: G000240. DR SMARTDB: SM0000143. DR PATHODB: MR000016. DR PATHODB: MR000017. DR PATHODB: MR000018. DR PATHODB: MR000019. DR TRRD: 00424. DR LOCUSLINK: 3045. DR OMIM: 142000. DR REFSEQ: NM_000519. XX RN [1] RX MEDLINE; 92385832. RA Matsuda M., Sakamoto N., Fukumaki Y. RT delta-Thalassemia caused by disruption of the site for an RT erythroid-specific transcription factor, GATA-1, in the Delta-globin gene RT promoter RL Blood 80:1347-1351 (1992). RN [2] RX MEDLINE; 92020969. RA O'Neill D., Bornschlegel K., Flamm M., Castle M., Bank A. RT A DNA-binding factor in adult hematopoietic cells interacts with a RT pyrimidine-rich domain upstream from the human delta-globin gene RL Proc. Natl. Acad. Sci. USA 88:8953-8957 (1991). XX // AC G000241 XX ID HS$DHFR XX DT 14.06.1995 (created); dbo. DT 14.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD DHFR XX DE dihydrofolate reductase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 5q11.2-q13.2 XX BC 6.1.4.2 XX BS -760 -670 R00278; HS$DHFR_01. BS -340 -270 R00279; HS$DHFR_02. BS -270 -170 R00280; HS$DHFR_03. BS -85 -78 R08813; HS$DHFR_08; Binding factors: Sp1 . BS -67 -56 R08811; HS$DHFR_07; Binding factors: E2F . BS -48 -39 R04679; HS$DHFR_05; Binding factors: Sp1 . BS -34 -15 R03158; HS$DHFR_04; Binding factors: TBP . BS -14 -5 R04680; HS$DHFR_06; Binding factors: Sp1 . XX DR EMBL: X00855; HSDHFR01. DR TRANSPATH: G000241. DR BRENDA: 1.5.1.3; Human. DR TRRD: 00024. DR LOCUSLINK: 1719. DR OMIM: 126060. DR REFSEQ: NM_000791. XX RN [1] RA Chen K. Y. RT Transcription factors and the down-regulation of G1/S boundary Genes in RT human diploid fibroblasts during senescence RL Frontiers in Bioscience 2:417-426 (1997). RN [2] RX MEDLINE; 96413758. RA Good L., Dimri G. P., Campisi J., Chen K. Y. RT Regulation of dihydrofolate reductase gene expression and E2F components in RT human diploid fibroblasts during growth and senescence RL Frontiers in Bioscience 168:580-588 (1996). RN [3] RX MEDLINE; 92335188. RA Wiley S. R., Kraus R. J., Mertz J. E. RT Functional binding of the TATA box binding component of transcription RT factor TFIID to the -30 region of TATA-less promoters RL Proc. Natl. Acad. Sci. USA 89:5814-5818 (1992). RN [4] RX MEDLINE; 92283818. RA Gee J. E., Blume S., Snyder R. C., Ray R., Miller D. M. RT Triplex formation prevents Sp1 binding to the dihydrofolate resuctase RT promoter RL J. Biol. Chem. 267:11163-11167 (1992). RN [5] RX MEDLINE; 86111796. RA Shimada T., Inokuchi K., Nienhuis A. W. RT Chromatin structure of the human dihydrofolate reductase gene promoter RL J. Biol. Chem. 261:1445-1452 (1986). XX // AC G000242 XX ID HS$DPOLA XX DT 14.06.1995 (created); dbo. DT 21.05.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD DPOLA XX DE DNA polymerase alpha XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH Xp22.1-p21.3 XX BC 6.1.4.1 XX BS -152 -142 R03036; HS$DPOLA_01; Binding factors: AP-1 . BS -138 -126 R03037; HS$DPOLA_02; Binding factors: EIIaE-A . BS -46 -22 R03038; HS$DPOLA_03; Binding factors: CP1 , CTF BS . XX DR EMBL: M64481; HSDNAPOL. DR EMBL: X66868; HSPOLA. DR TRANSPATH: G000242. DR BRENDA: 2.7.7.7; Human. DR TRRD: 00370. DR LOCUSLINK: 5422. DR OMIM: 312040. DR REFSEQ: NM_002689. XX RN [1] RX MEDLINE; 91172197. RA Pearson B. E., Nasheuer H.-P., Wang T. S.-F. RT Human DNA polymerase alpha gene: sequences controlling expression in RT cycling and serum-stimulated cells RL Mol. Cell. Biol. 11:2081-2095 (1991). XX // AC G000243 XX ID HS$DPOLB XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD POLB XX DE DNA polymerase beta XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 8p12-p11 XX BC 6.1.4.1 XX BS -75 -56 R00287; HS$DPOLB_01; Binding factors: Sp1 . BS -54 -33 R00288; HS$DPOLB_02; Binding factors: CREB , CRE-BP1 BS , 43K protein . BS -29 -21 R00289; HS$DPOLB_03. BS -23 -20 R00290; HS$DPOLB_04. BS -13 -10 R00291; HS$DPOLB_05. BS 33 47 R00292; HS$DPOLB_06. XX DR EMBL: J04201; HSPOLBA. DR TRANSPATH: G000243. DR BRENDA: 2.7.7.7; Human. DR LOCUSLINK: 5423. DR OMIM: 174760. DR REFSEQ: NM_002690. XX RN [1] RX MEDLINE; 91219445. RA Kedar P. S., Widen S. G., Englander E. W., Fornace jr A. J., Wilson S. H. RT The ATF/CREB transcription factor-binding site in the polymerase beta RT promoter mediates the positive effect of RT N-methyl-N'-nitro-N-nitrosoguanidine on transcription RL Proc. Natl. Acad. Sci. USA 88:3729-3733 (1991). RN [2] RX MEDLINE; 90192168. RA Englander E. W., Wilson S. H. RT Protein binding elements in the human beta-polymerase promoter RL Nucleic Acids Res. 18:919-928 (1990). XX // AC G000246 XX ID HS$EGR2 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD EGR2 XX DE early growth response gene 2 XX SY KROX20. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 10q21.1 XX BS -377 -342 R00394; HS$EGR2_01. BS -73 -53 R00395; HS$EGR2_02. XX FA T00242; EGR2. XX DR EMBL: X53700; HSGEGR2. DR TRANSPATH: G000246. DR LOCUSLINK: 1959. DR OMIM: 129010. DR REFSEQ: NM_000399. XX RN [1] RX MEDLINE; 90251451. RA Rangnekar V. M., Aplin A. C., Sukhatme V. P. RT The serum and TPA responsive promoter and intron-exon structure of EGR2, a RT human early growth response gene encoding a zinc finger protein RL Nucleic Acids Res. 18:2749-2757 (1990). XX // AC G000247 XX ID HS$EIF2A XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD eIF-2alpha XX DE eukaryotic translation initiation factor 2 alpha XX SY EIF2; EIF2A. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 14q21.3 XX BC 6.1.2.3 XX BS -74 -10 R01727; HS$EIF2A_01; Binding factors: NRF-1 . BS -42 -21 R09526; HS$EIF2A_02; Binding factors: NRF-1 . XX DR EMBL: X12421; HSEIF2AP. DR TRANSPATH: G000247. DR TRRD: 00025. DR LOCUSLINK: 1965. DR OMIM: 603907. DR REFSEQ: NM_004094. XX RN [1] RA Chau C. A., Evans M. J., Scarpulla R. C. RT Nuclear respiratory factor 1 activation sites in genes encoding the RT gamma-subunit of ATP synthase, eukaryotic initiation factor 2alpha, and RT tyrosine aminotransferase RL J. Biol. Chem. 267:6999- 7006 (1992). RN [2] RX MEDLINE; 90062168. RA Jacob W. F., Silverman T. A., Cohen R. B., Safer B. RT Identification and Characterization of a Novel Transcription Factor RT Participating in the Expression of Eukaryotic Initiation Factor 2alpha RL J. Biol. Chem. 264:20372-20384 (1989). XX // AC G000248 XX ID HS$SELE XX DT 14.06.1995 (created); dbo. DT 06.11.2001 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD SELE XX DE E-selectin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1q22-q25 XX BC 6.1.5 XX BS -166 -129 R11552; HS$SELE_02; Binding factors: c-Jun , ATF3 BS , ATF2 . BS -97 -83 R03275; HS$SELE_01; Binding factors: NF-kappaB . XX DR EMBL: M64485; HSELAM1B. DR TRANSPATH: G000248. DR TRANSCOMPEL: C00056. DR TRANSCOMPEL: C00058. DR TRANSCOMPEL: C00059. DR TRANSCOMPEL: C00062. DR TRANSCOMPEL: C00093. DR TRANSCOMPEL: C00097. DR TRANSCOMPEL: C00102. DR TRANSCOMPEL: C00103. DR TRANSCOMPEL: C00306. DR TRRD: 00198. DR LOCUSLINK: 6401. DR OMIM: 131210. DR REFSEQ: NM_000450. XX RN [1] RX MEDLINE; 20422272. RA Nawa T., Nawa M. T., Cai Y., Zhang C., Uchimura I., Narumi S., Numano F., RA Kitajima S. RT Repression of TNF-alpha-induced E-selectin expression by PPAR activators: RT involvement of transcriptional repressor LRF-1/ATF3 RL Biochem. Biophys. Res. Commun. 275:406-411 (2000). RN [2] RX MEDLINE; 91252208. RA Whelan J., Ghersa P., Hooft van Huijsduijnen R., Gray J., Chandra G., RA Talabot F., DeLamarter J. F. RT An NFkappaB-like factor is essential but not sufficient for cytokine RT induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene RT transcription RL Nucleic Acids Res. 19:2645 (1991). XX // AC G000249 XX ID HS$ELN XX DT 21.05.1996 (created); ake. DT 29.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD ELN XX DE elastin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 7q11.1-q21.1 XX BC 6.1.2.7 XX DR TRRD: 00026. DR LOCUSLINK: 2006. DR OMIM: 130160. DR REFSEQ: NM_000501. XX // AC G000250 XX ID HS$ERV9 XX DT 21.05.1996 (created); ake. DT 21.05.1996 (updated); ake. CO Copyright (C), Biobase GmbH. XX SD ERVV9 XX DE endogenous retroviral element 9 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.2.1.1 XX DR TRRD: 00064. XX // AC G000251 XX ID HS$EGFR XX DT 14.06.1995 (created); dbo. DT 27.11.2001 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD EGFR XX DE epidermal growth factor receptor XX SY ERBB. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 7p12 XX BC 6.1.5.13 XX BS -457 -444 R00374; HS$EGFR_01; Binding factors: Sp1 . BS -417 -402 R00375; HS$EGFR_02. BS -370 -340 R00376; HS$EGFR_03. BS -368 -339 R04926; HS$EGFR_24. BS -368 -339 R04927; HS$EGFR_25. BS -323 -314 R00377; HS$EGFR_04; Binding factors: Sp1 . BS -304 -286 R00378; HS$EGFR_05; Binding factors: Sp1 . BS -293 -281 R00379; HS$EGFR_06; Binding factors: ETF . BS -278 -263 R02641; HS$EGFR_21; Binding factors: GCF . BS -265 -239 R11723; HS$EGFR_26; Binding factors: p53 . BS -248 -233 R00380; HS$EGFR_07; Binding factors: ETF . BS -243 -225 R02642; HS$EGFR_22; Binding factors: GCF . BS -215 -200 R00381; HS$EGFR_08; Binding factors: Sp1 . BS -214 -204 R00382; HS$EGFR_09; Binding factors: ETF . BS -185 -161 R00383; HS$EGFR_10. BS -139 -126 R00384; HS$EGFR_11. BS -109 -84 R00385; HS$EGFR_12; Binding factors: RPF1 , Sp1 BS . BS -100 -90 R03960; HS$EGFR_23; Binding factors: T3R-beta1 , BS RXR-alpha . BS -39 -19 R00386; HS$EGFR_13. BS 27 43 R00387; HS$EGFR_14. BS 74 79 R00388; HS$EGFR_15. BS 89 94 R00389; HS$EGFR_16. BS 102 113 R00390; HS$EGFR_17. BS 122 129 R00391; HS$EGFR_18. BS 136 141 R00392; HS$EGFR_19. BS 148 153 R00393; HS$EGFR_20. XX DR EMBL: AF288738; AF288738. DR EMBL: M22310; HSEGFE2. DR EMBL: M38425; HSEGFR01. DR EMBL: X06370; HSEGFR1. DR EMBL: M11234; HSEGFRG. DR EMBL: J03206; HSEGFRO. DR TRANSPATH: G000251. DR TRRD: 00197. DR LOCUSLINK: 1956. DR OMIM: 131550. DR REFSEQ: NM_005228. XX RN [1] RX MEDLINE; 97042430. RA Ludes-Meyers J. H., Subler M. A., Shivakumar C. V., Munoz R. M., Jiang P., RA Bigger J. E., Brown D. R., Deb S. P., Deb S. RT Transcriptional activation of the human epidermal growth factor receptor RT promoter by human p53. RL Mol. Cell. Biol. 16:6009-6019 (1996). RN [2] RX MEDLINE; 96030772. RA Englert C., Hou X., Maheswaran S., Bennett P., Ngwu C., Re G. G., Garvin A. RA J., Rosner M. R., Haber D. A. RT WT1 suppresses synthesis of the epidermal growth factor receptor and RT induces apoptosis RL EMBO J. 14:4662-4676 (1995). RN [3] RX MEDLINE; 94203663. RA Deb S. P., Munoz R. M., Brown D. R., Subler M. A., Deb S. RT Wild-type human p53 activates the human epidermal growth factor receptor RT promoter. RL Oncogene 9:1341-1349 (1994). RN [4] RX MEDLINE; 93340220. RA Xu J., Thompson K. L., Shephard L. B., Hudson L. G., Gill G. N. RT T3 receptor suppression of Sp1-dependent transcription from the epidermal RT growth factor receptor promoter via overlapping DNA-binding sites RL J. Biol. Chem. 268:16065-16073 (1993). RN [5] RX MEDLINE; 91017540. RA Hudson L. G., Thompson K. L., Xu J., Gill G. N. RT Identification and characterization of a regulated promoter element in the RT epidermal growth factor receptor gene RL Proc. Natl. Acad. Sci. USA 87:7536-7540 (1990). RN [6] RX MEDLINE; 90075226. RA Kageyama R., Pastan I. RT Molecular Cloning and Characterization of a Human DNA Binding Factor That RT Represses Transcription RL Cell 59:815-825 (1989). RN [7] RX MEDLINE; 89359391. RA Kageyama R., Merlino G. T., Pastan I. RT Nuclear Factor ETF Specifically Stimulates Transcription from Promoters RT without a TATA Box RL J. Biol. Chem. 264:15508-15514 (1989). RN [8] RX MEDLINE; 89174588. RA Maekawa T., Imamoto F., Merlino G. T., Pastan I., Ishii S. RT Cooperative Function of Two Separate Enhancers of the Human Epidermal RT Growth Factor Receptor Proto-oncogene RL J. Biol. Chem. 264:5488-5494 (1989). RN [9] RX MEDLINE; 88186885. RA Johnson A. C., Ishii S., Jinno Y., Pastan I., Merlino G. T. RT Epidermal Growth Factor Receptor Gene Promoter RL J. Biol. Chem. 263:5693-5699 (1988). RN [10] RX MEDLINE; 89039842. RA Johnson A. C., Jinno Y., Merlino G. T. RT Modulation of Epidermal Growth Factor Receptor Proto-Oncogene Transcription RT by a promoter Site Sensitive to S1 Nuclease RL Mol. Cell. Biol. 8:4174-4184 (1988). RN [11] RX MEDLINE; 88276890. RA Kageyama I., Merlino R., Pastan G.T. RT A transcription factor active on the epidermal growth factor receptor gene RL Proc. Natl. Acad. Sci. USA 85:5016-5020 (1988). XX // AC G000252 XX ID HS$EK14 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD K14 XX DE epidermal type I keratin XX SY EBS4; EBS3. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17q12-q21 XX BC 6.1.2.6 XX BS -240 -195 R03674; HS$EK14_01; Binding factors: AP-2alphaA . XX DR EMBL: X59475; HS5K14G. DR TRANSPATH: G000252. DR LOCUSLINK: 3861. DR OMIM: 148066. DR REFSEQ: NM_000526. XX RN [1] RX MEDLINE; 91115087. RA Leask A., Rosenberg M., Vassar R., Fuchs E. RT Regulation of a human epidermal keratin gene: sequences and nuclear factors RT involved in keratinocyte-specific transcription RL Genes Dev. 4:1985-1998 (1990). XX // AC G000253 XX ID HS$EG XX DT 14.06.1995 (created); dbo. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-E XX DE epsilon-globin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.5 XX BC 6.1.3.10.3 XX BS -379 0 R08142; HS$EG_11. BS -284 -258 R03113; HS$EG_01; Binding factors: GATA-1 , YY1 BS . BS -240 -230 R03114; HS$EG_02. BS -218 -201 R03115; HS$EG_03; Binding factors: GATA-1 . BS -170 -160 R03116; HS$EG_04; Binding factors: GATA-1 , GATA-1 BS . BS -147 -134 R03117; HS$EG_05; Binding factors: epsilonF1 . BS -120 -102 R03118; HS$EG_06; Binding factors: Sp1 . BS -84 -65 R03119; HS$EG_07; Binding factors: CP1 . BS -34 -23 R03120; HS$EG_08. BS -4 16 R03121; HS$EG_09. XX DR EMBL: V00508; HSEGL1. DR EMBL: X00420; HSGL07. DR EMBL: U01317; HSHBB. DR TRANSPATH: G000253. DR SMARTDB: SM0000141. DR SMARTDB: SM0000142. DR SMARTDB: SM0000178. DR TRRD: 00323. DR LOCUSLINK: 3046. DR OMIM: 142100. DR REFSEQ: NM_005330. XX RN [1] RX MEDLINE; 95188884. RA Raich N., Clegg C. H., Grofti J., Romeo P.-H., Stamatoyannopoulos G. RT GATA1 and YY1 are developmental repressors of the human epsilon-globin gene RL EMBO J. 14:801-809 (1995). RN [2] RX MEDLINE; 93155191. RA Peters B., Merezhinskaya N., Diffley J. F. X., Noguchi C. T. RT Protein-DNA interactions in the epsilon-globin gene silencer RL J. Biol. Chem. 268:3430-3437 (1993). RN [3] RX MEDLINE; 91224987. RA Yu C.-Y., Motamed K., Chen J., Bailey A. D., Shen C.-K. J. RT The CACC box upstream of human embryonic epsilon globin gene binds Sp1 and RT is a functional promoter element in vitro and in vivo RL J. Biol. Chem. 266:8907-8915 (1991). RN [4] RX MEDLINE; 91203876. RA Gong Q.-H., Stern J., Dean A. RT Transcriptional role of a conserved GATA-1 site in the human epsilon-globin RT gene promoter RL Mol. Cell. Biol. 11:2558-2566 (1991). XX // AC G000254 XX ID HS$EPO XX DT 14.06.1995 (created); dbo. DT 21.05.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Epo XX DE erythropoietin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 7q21 XX BC 6.1.5 XX BS 3380 3411 R03216; HS$EPO_01. BS 3403 3427 R03218; HS$EPO_03. BS 3424 3430 R03217; HS$EPO_02. BS 3431 3449 R03221; HS$EPO_06. BS 3449 3471 R03219; HS$EPO_04; Binding factors: HIF-1 , HIF-1 BS . BS 3482 3504 R03220; HS$EPO_05; Binding factors: Tf-LF1 , Tf-LF2 BS . XX DR EMBL: M11319; HSERPA. DR TRANSPATH: G000254. DR TRANSCOMPEL: C00124. DR TRANSCOMPEL: C00125. DR TRRD: 00292. DR LOCUSLINK: 2056. DR OMIM: 133170. DR REFSEQ: NM_000799. XX RN [1] RX MEDLINE; 95138113. RA Wang G. L., Semenza G. L. RT Purification and characterization of hypoxia-inducible factor 1. RL J. Biol. Chem. 270:1230-1237 (1995). RN [2] RX MEDLINE; 91288528. RA Semenza G. L., Nejfelt M. K., Chi S. M., Antonarakis S. E. RT Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to RT the human erythropoietin gene RL Proc. Natl. Acad. Sci. USA 88:5680-5684 (1991). XX // AC G000255 XX ID HS$ET1 XX DT 14.06.1995 (created); dbo. DT 21.08.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ET-1 XX DE preproendothelin-1 XX SY ET1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p23-p24 XX BC 6.1.5 XX BS -141 -127 R02797; HS$ET1_01; Binding factors: GATA-2 . BS -132 -113 R10172; HS$ET1_03; Binding factors: HIF-1 , HIF-1 BS . BS -109 -102 R04127; HS$ET1_02; Binding factors: AP-1 , c-Fos BS , c-Jun . XX DR EMBL: J05008; HSEDN1B. DR TRANSPATH: G000255. DR TRANSCOMPEL: C00147. DR LOCUSLINK: 1906. DR OMIM: 131240. DR REFSEQ: NM_001955. XX RN [1] RX MEDLINE; 21201088. RA Yamashita K., Discher D. J., Hu J., Bishopric N. H., Webster K. A. RT Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of RT hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. RL J. Biol. Chem. 276:12645-12653 (2001). RN [2] RX MEDLINE; 98249810. RA Hu J., Discher D. J., Bishopric N. H., Webster K. A. RT Hypoxia regulates expression of the endothelin-1 gene through a proximal RT hypoxia-inducible factor-1 binding site on the antisense strand. RL Biochem. Biophys. Res. Commun. 245:894-899 (1998). RN [3] RX MEDLINE; 92112773. RA Dorfman D. M., Wilson D. B., Bruns G. A. P., Orkin S. H. RT Human transcription factor GATA-2. Evidence for regulation of RT preproendothelin-1 gene expression in endothelial cells. RL J. Biol. Chem. 267:1279-1285 (1992). RN [4] RX MEDLINE; 92011678. RA Lee M.-E., Dhadley M. S., Temizer D. H., Clifford J. A., Yoshizumi M., RA Quertermous T. RT Regulation of endothelin-1 gene expression by Fos and Jun RL J. Biol. Chem. 266:19034-19039 (1991). RN [5] RX MEDLINE; 90356002. RA Wilson D. B., Dorfman D. M., Orkin S. H. RT A nonerythroid GATA-binding protein is required for function of the human RT preproendothelin-1 promoter in endothelial cells RL Mol. Cell. Biol. 10:4854-4862 (1990). XX // AC G000256 XX ID HS$FIX XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD factor IX XX DE antihemophilic factor B, christmas factor XX SY FIX; FactorIX. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH Xq26.3-q27.1 XX BC 6.1.6.6 XX BS -99 -76 R00421; HS$FIX_01; Binding factors: ENKTF-1 , NF-1/L BS . BS -40 -9 R09458; HS$FIX_04; Binding factors: AR , HNF-4alpha BS . BS 1 20 R00422; HS$FIX_02; Binding factors: C/EBPalpha , BS C/EBPalpha . XX DR EMBL: K02402; HSFIXG. DR TRANSPATH: G000256. DR SMARTDB: SM0000176. DR SMARTDB: SM0000177. DR PATHODB: MR000021. DR PATHODB: MR000022. DR PATHODB: MR000023. DR PATHODB: MR000025. DR PATHODB: MR000026. DR PATHODB: MR000027. DR LOCUSLINK: 2158. DR OMIM: 306900. DR REFSEQ: NM_000133. XX RN [1] RX MEDLINE; 92335882. RA Crossley M., Ludwig M., Stowell K. M., de Vos P., Olek K., Brownlee G. G. RT Recovery from hemophilia B Leyden: an androgen-responsive element in the RT factor IX promoter RL Science 257:377-379 (1992). RN [2] RX MEDLINE; 90259094. RA Crossley M., Brownlee G. G. RT Disruption of a C/EBP binding site in the factor IX promoter is associated RT with haemophilia B RL Nature 345:444-446 (1990). XX // AC G000258 XX ID HS$FIB2 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD FIB2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BS -65 -50 R00435; HS$FIB2_01; Binding factors: NF-1 . XX DR TRANSPATH: G000258. XX RN [1] RX MEDLINE; 89356660. RA Cleat P. H., Hay R. T. RT Co-operative interactions between NFI and the adenovirus DNA binding RT protein at the adenovirus origin of replication RL EMBO J. 8:1841-1848 (1989). RN [2] RX MEDLINE; 86140112. RA Adhya S., Shneidman P. S., Hurwitz J. RT Reconstruction of adenovirus replication origins with a human nuclear RT factor I binding site RL J. Biol. Chem. 261:3339-3346 (1986). RN [3] RX MEDLINE; 84248049. RA Gronostajski R. M., Nagata K., Hurwitz J. RT Isolation of human DNA sequences that bind to nuclear factor I, a host RT protein involved in adenovirus DNA replication RL Proc. Natl. Acad. Sci. USA 81:4013-4017 (1984). XX // AC G000259 XX ID HS$FN XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD FN XX DE fibronectin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 2q34-q36 XX BC 6.1.2.8 XX BS -430 -402 R00454; HS$FN_01; Binding factors: CREB . BS -386 -376 R04033; HS$FN_06. BS -273 -252 R02927; HS$FN_05; Binding factors: PEBP2 . BS -194 -160 R00455; HS$FN_02; Binding factors: c-Jun , CREB BS , CRE-BP1 , CREB , deltaCREB . BS -184 -155 R00456; HS$FN_03; Binding factors: CREB , CREB BS , CREBbeta . BS -160 -142 R00457; HS$FN_04; Binding factors: NF-1 . BS -105 -89 R04034; HS$FN_07; Binding factors: Sp1 . BS -65 -57 R04035; HS$FN_08; Binding factors: AP-2 . BS -47 -30 R04036; HS$FN_09. XX DR EMBL: M15801; HSFN3. DR EMBL: M26179; HSFNA. DR TRANSPATH: G000259. DR LOCUSLINK: 2335. DR OMIM: 135600. DR REFSEQ: NM_002026. XX RN [1] RX MEDLINE; 94248047. RA Benbrook D. M., Jones N. C. RT Different binding specificities and transactivation of variant CRE's by RT CREB complexes RL Nucleic Acids Res. 22:1463-1469 (1994). RN [2] RX MEDLINE; 92371441. RA Nichols M., Weih F., Schmid W., DeVack C., Kowenz-Leutz E., Luckow B., RA Boshart M., Schuetz G. RT Phosphorylation of CREB affects its binding to high and low affinity sites: RT implications for cAMP induced gene transcription RL EMBO J. 11:3337-3346 (1992). RN [3] RX MEDLINE; 91216102. RA Kramer I. M., Koornneef I., de Laat S. W., van den Eijnden-van Raaij A. J. RA M. RT TGF-beta1 induces phosphorylation of the cyclic AMP responsive element RT binding protein in ML-CCI64 cells RL EMBO J. 10:1083-1089 (1991). RN [4] RX MEDLINE; 91093221. RA Bowlus Ch. L., McQuillan J. J., Dean D. C. RT Characterization of three different elements in the 5'-flanking region of RT the fibronectin gene which mediate a transcriptional response to cAMP RL J. Biol. Chem. 266:1122-1127 (1991). RN [5] RX MEDLINE; 91009310. RA Bernath V. A., Muro A. F., Vitullo A. D., Bley M. A., Baranao J. L., RA Kornblihtt A. R. RT Cyclic AMP inhibits fibronectin gene expression in a newly developed RT granulosa cell line by a mechanism that suppresses cAMP-responsive RT element-dependent transcriptional activation RL J. Biol. Chem. 265:18219-18226 (1990). RN [6] RX MEDLINE; 91125364. RA Andersen B., Kennedy G. C., Hamernik D. L., Bokar J. A., Bohinski R., RA Nilson J. H. RT Amplification of the transcriptional signal mediated by the tandem cAMP RT response elements of the glycoprotein hormone alpha-subunit gene occurs RT through several distinct mechanisms RL Mol. Endocrinol. 4:573-582 (1990). RN [7] RX MEDLINE; 90191714. RA Benbrook D. M., Jones N. C. RT Heterodimer formation between CREB and JUN proteins RL Oncogene 5:295-302 (1990). RN [8] RX MEDLINE; 89261777. RA Dean D. C., Blakeley M. S., Newby R. F., Ghazal P., Hennighausen L., RA Bourgeois S. RT Forskolin Inducibility and Tissue-Specific Expression of the Fibronectin RT Promoter RL Mol. Cell. Biol. 9:1498-1506 (1989). RN [9] RX MEDLINE; 88247984. RA Hardy S., Shenk T. RT Adenoviral control regions activated by E1A and the cAMP responsive element RT bind to the same factor RL Proc. Natl. Acad. Sci. USA 85:4171-4175 (1988). XX // AC G000260 XX ID HS$GCSF XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD G-CSF XX DE granulocyte colony-stimulating factor XX SY GCSF. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17q11.2-q12 XX BC 6.1.5.9 XX BS -188 -179 R02683; HS$GCSF_01; Binding factors: NF-GMa . XX DR EMBL: X03656; HSGCSFG. DR TRANSPATH: G000260. DR TRANSCOMPEL: C00154. DR LOCUSLINK: 1440. DR OMIM: 138970. DR REFSEQ: NM_000759. XX RN [1] RX MEDLINE; 90258885. RA Shannon M. F., Pell L. M., Lenardo M. J., Kuczek E. S., Occhiodoro F. S., RA Dunn St. M., Vadas M. A. RT A Novel Tumor Necrosis Factor-Responsive Transcription Factor Which RT Recognizes a Regulatory Element in Hemopoietic Growth Factor Genes RL Mol. Cell. Biol. 10:2950-2959 (1990). XX // AC G000261 XX ID HS$AGG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-AG XX DE Agamma-globin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.5 XX BC 6.1.3.10.3 XX BS -12850 0 R04196; HS$GG_37; Binding factors: GATA-1 , POU2F1 BS . BS -2670 0 R04197; HS$GG_38; Binding factors: GATA-1 , POU2F1 BS . BS -1250 0 R04198; HS$GG_39; Binding factors: CSBP-1 . BS -960 0 R04199; HS$GG_40. BS -930 0 R04200; HS$GG_41; Binding factors: CP1 , GATA-1 BS , POU2F1 . BS -810 0 R04201; HS$GG_42; Binding factors: GATA-1 , POU2F1 BS . BS -290 -268 R00547; HS$GG_01. BS -243 -235 R00548; HS$GG_02; Binding factors: GATA-1 . BS -228 -212 R03261; HS$GG_34; Binding factors: GATA-1 . BS -213 -191 R02599; HS$GG_23; Binding factors: Sp1 . BS -208 -190 R02621; HS$GG_24; Binding factors: Sp1 . BS -201 -156 R00549; HS$GG_03; Binding factors: GATA-1 , POU2F1 BS . BS -196 -182 R00551; HS$GG_05; Binding factors: GATA-1 , POU2F1 BS . BS -191 -168 R00550; HS$GG_04; Binding factors: GATA-1 , GATA-1 BS . BS -190 -180 R00552; HS$GG_06; Binding factors: GATA-1 . BS -190 -170 R00553; HS$GG_07. BS -188 -184 R00554; HS$GG_08; Binding factors: NF-E . BS -184 -170 R00555; HS$GG_09. BS -184 -167 R00556; HS$GG_10; Binding factors: (gamma)OBP . BS -183 -171 R00557; HS$GG_11; Binding factors: POU2F1 , POU2F2 BS . BS -172 -168 R00558; HS$GG_12; Binding factors: NF-E . BS -155 -126 R00559; HS$GG_13; Binding factors: gammaCAC1 , BS gammaCAC2 . BS -153 -134 R00560; HS$GG_14; Binding factors: CACCC-binding factor BS , Sp1 . BS -132 -91 R01858; HS$GG_19; Binding factors: CP1 , GATA-1 BS , CP1 , NFE-6 . BS -132 -91 R02888; HS$GG_33; Binding factors: CP1 , CP1 BS , NFE-6 . BS -127 -91 R01859; HS$GG_20; Binding factors: CP1 , NF-E3 BS . BS -117 -98 R00561; HS$GG_15; Binding factors: NF-E , NF-E BS . BS -117 -70 R00562; HS$GG_16; Binding factors: CUTL1 , Clox BS , Cutl1 , CDP2 . BS -114 0 R02048; HS$GG_21; Binding factors: CP1 . BS -114 0 R02049; HS$GG_22. BS -96 -70 R00563; HS$GG_17; Binding factors: gammaCAAT . BS -90 -82 R00564; HS$GG_18; Binding factors: CP1 , CP1 . BS -50 0 R04195; HS$GG_36; Binding factors: Sp1 . BS -24 -23 R04084; HS$GG_35. BS -5 28 R08244; HS$GG_43. BS 11 43 R08245; HS$GG_44; Binding factors: GATA-1 . BS 1991 2023 R02825; HS$GG_25; Binding factors: PPUR . BS 2088 2096 R02826; HS$GG_26; Binding factors: GATA-1 . BS 2133 2152 R02827; HS$GG_27. BS 2261 2294 R02828; HS$GG_28; Binding factors: PPUR . BS 2405 2418 R02829; HS$GG_29; Binding factors: GATA-1 . BS 2428 2457 R02830; HS$GG_30. BS 2467 2502 R02831; HS$GG_31; Binding factors: GATA-1 . BS 2550 2573 R02832; HS$GG_32. XX DR EMBL: M91036; HSGAMGLOA. DR EMBL: M91037; HSGAMGLOB. DR EMBL: X52069; HSGGG. DR EMBL: X00424; HSGL09. DR EMBL: U01317; HSHBB. DR EMBL: M32724; HSHBBAG. DR EMBL: M33200; HSHBGAA. DR TRANSPATH: G000261. DR SMARTDB: SM0000141. DR SMARTDB: SM0000142. DR SMARTDB: SM0000178. DR TRRD: 00297. DR LOCUSLINK: 3047. DR OMIM: 142200. DR REFSEQ: NM_000559. XX RN [1] RX MEDLINE; 96189105. RA Trainor C. D., Omichinski J. G., Vandergon T. L., Gronenborn A. M., Clore RA G. M., Felsenfeld G. RT A palindromic regulatory site within vertebtrate GATA-1 promoters requires RT both zinc fingers of the GATA-1 DNA-binding domain for high-affinity RT interaction RL Mol. Cell. Biol. 16:2238-2247 (1996). RN [2] RA Amrolia P. J., Cunningham J. M., Ney P., Nienhuis A. W., Jane S. M. RT Identification of two novel regulatory elements within the 5'-untranslated RT region of the human Agamma-globin gene RL J. Biol. Chem. 270:12892-12898 (1995). RN [3] RX MEDLINE; 94043213. RA Fischer K. D., Haese A., Nowock J. RT Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional RT activation or interference RL J. Biol. Chem. 268:23915-23923 (1993). RN [4] RX MEDLINE; 92350300. RA Berry M., Grosveld F., Dillon N. RT A single point mutation is the cause of the Greek form of hereditary RT persistance of fetal hemoglobin RL Nature 358:499-502 (1992). RN [5] RX MEDLINE; 93024437. RA Gumucio D. L., Heilstedt-Williamson H., Gray T. A., Tarle S. A., Shelton D. RA A., Tagle D. A., Slightom J. L., Goodman M., Collins F. S. RT Phylogenetic footprinting reveals a nulear protein which binds to silencer RT sequences in the human gamma and epsilon globin genes RL Mol. Cell. Biol. 12:4919-4929 (1992). RN [6] RX MEDLINE; 93066255. RA Walters M., Martin D. I. K. RT Functional erythroid promoters created by interaction of the transcription RT factor GATA-1 with CACCC and AP-1/NFE-2 elements. RL Proc. Natl. Acad. Sci. USA 89:10444-10448 (1992). RN [7] RX MEDLINE; 91268074. RA McDonagh K. T., Lin H. J., Lowrey C. H., Bodine D. M., Nienhuis A. W. RT The upstream region of the human gamma-globin gene promoter RL J. Biol. Chem. 266:11965-11974 (1991). RN [8] RX MEDLINE; 92052236. RA Ikuta T., Kan Y. W. RT In vivo protein-DNA interactions at the beta-globin gene locus RL Proc. Natl. Acad. Sci. USA 88:10188-10192 (1991). RN [9] RX MEDLINE; 91115078. RA Martin D. I. K., Orkin St. H. RT Transcriptional activation and DNA binding by the erythroid factor RT GF-1/NF-E1/Eryf 1 RL Genes Dev. 4:1886-1898 (1990). RN [10] RX MEDLINE; 90097868. RA Sykes K., Kaufman R. RT A Naturally Occurring Gamma Globin Gene Mutation Enhances SP1 Binding RT Activity RL Mol. Cell. Biol. 10:95-102 (1990). RN [11] RX MEDLINE; 91061767. RA Whitelaw E., Tsai Sh.-F., Hogben P., Orkin St. H. RT Regulated expression of globin chains and the erythroid transcription RT factor GATA-1 during erythropoiesis in the developing mouse RL Mol. Cell. Biol. 10:6596-6606 (1990). RN [12] RX MEDLINE; 90206048. RA Martin D. I. K., Zon L. I., Mutter G., Orkin S. H. RT Expression of an erythroid transcription factor in megakaryocytic and mast RT cell lineages RL Nature 344:444-447 (1990). RN [13] RX MEDLINE; 90384826. RA Fucharoen S., Shimizu K., Fukumaki Y. RT A novel C-T transition within the distal CCAAT motif of the Ggamma-globin RT gene in the Japanese HPFH: implication of factor binding in elevated fetal RT globin expression RL Nucleic Acids Res. 18:5245 (1990). RN [14] RX MEDLINE; 90245638. RA O'Neill D., Kaysen J., Donovan-Peluso M., Castle M., Bank A. RT Protein-DNA interactions upstream from the Human A gamma globin gene RL Nucleic Acids Res. 18:1977 (1990). RN [15] RX MEDLINE; 91088258. RA Crotta S., Nicolis S., Ronchi A., Ottolenghi S., Ruzzi L., Shimada Y., RA Migliaccio A. R., Migliaccio G. RT Progressive inactivation of the expression of an erythroid transcriptional RT factor in GM- and G-CSF-dependent myeloid cell lines RL Nucleic Acids Res. 18:6863 (1990). RN [16] RX MEDLINE; 91081330. RA Purucker M., Bodine D., Lin H., McDonagh K., Nienhuis A. W. RT Structure and function of the enhancer 3' to the human Agamma globin gene RL Nucleic Acids Res. 18:7407 (1990). RN [17] RX MEDLINE; 89181931. RA Martin D. I. K., Tsai S.-F., Orkin S. H. RT Increased gamma-globin expression in a nondeletion HPFH mediated by an RT erythroid-specific DNA-binding factor RL Nature 338:435-438 (1989). RN [18] RX MEDLINE; 89262083. RA Tsai S.-F., Martin D. I. K., Zon L. I., D'Andrea A. D., Wong G. G., Orkin RA S. H. RT Cloning of cDNA for the major DNA-binding protein of the erythroid lineage RT through expression in mammalian cells RL Nature 339:446-451 (1989). RN [19] RX MEDLINE; 89282387. RA Catala F., deBoer E., Habets G., Grosveld F. RT Nuclear protein factors and erythroid transcription of the human RT Agamma-globin gene RL Nucleic Acids Res. 17:3811-3827 (1989). RN [20] RX MEDLINE; 89160238. RA Broggini M., Ponti M., Ottolenghi S., D'Incalci M., Mongelli N., Mantovani RA R. RT Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their RT conserved DNA elements RL Nucleic Acids Res. 17:1051-1059 (1989). RN [21] RX MEDLINE; 89385992. RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S. RT The deletion of the distal CCAAT box region of the Agamma-globin gene in RT black HPFH abolishes the binding of the erythroid specific protein NFE3 and RT of the CCAAT displacement protein RL Nucleic Acids Res. 17:6681-6691 (1989). RN [22] RX MEDLINE; 89296476. RA Lloyd J. A., Lee R. F., Lingrel L. B. RT Mutations in two regions upstream of the Agamma globin gene canonical RT promoter affect gene expression RL Nucleic Acids Res. 17:4339-4352 (1989). RN [23] RX MEDLINE; 90098865. RA Ronchi A., Nicolis S., Santoro C., Ottolenghi S. RT Increased Sp1 binding mediates erythroid-specific overexpression of a RT mutated (HPFH) gamma-globulin promoter RL Nucleic Acids Res. 17:10231-10241 (1989). RN [24] RX MEDLINE; 89030605. RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M. RT The -117 mutation in Greek HPFH affects the binding of three nuclear RT factors to the CCAAT region of the gamma-globin gene RL EMBO J. 7:3099-3107 (1988). RN [25] RX MEDLINE; 89218991. RA Gumucio D. L., Rood K. L., Gray T. A., Riordan M. F., Sartor C. I., Collins RA F. S. RT Nuclear Proteins That Bind the Human gamma-Globin Gene Promoter: RT Alterations in Binding Produced by Point Mutations Associated with RT Hereditary Persistence of Fetal Hemoglobin RL Mol. Cell. Biol. 8:5310-5322 (1988). RN [26] RX MEDLINE; 88335527. RA Mantovani R., Malgarettie N., Nicolis S., Ronchi A., Giglioni B., RA Ottolenghi S. RT The effects of HPFH mutations in the human gamma-globin promoter on binding RT of ubiquitous and erythroid specific nuclear factors RL Nucleic Acids Res. 16:7783-7797 (1988). RN [27] RX MEDLINE; 88067761. RA Mantovani R., Malgaretti N., Giglioni B., Comi P., Cappelini N., Nicolis RA S., Ottolenghi S. RT A protein factor binding to an octamer motif in the gamma-globin promoter RT disappears upon induction of differentiation and hemoglobin synthesis in RT K562 cells RL Nucleic Acids Res. 15:9349-9364 (1987). XX // AC G000262 XX ID HS$GAPDH XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GAPDH XX DE glyceraldehyde-3-phosphate dehydrogenase XX SY GAPD. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 12 XX BC 6.1.4 XX BS -480 -435 R02724; HS$GAPDH_01; Binding factors: SRY , IRE-ABP BS , SRY , SRY . XX DR EMBL: J04038; GAPDHG. DR TRANSPATH: G000262. DR SMARTDB: SM0000417. DR SMARTDB: SM0000418. DR BRENDA: 1.2.1.12; Human. DR LOCUSLINK: 113293. XX RN [1] RX MEDLINE; 92065959. RA Nasrin N., Buggs C., Kong X. F., Carnazza J., Goebl M., Alexander-Bridges M. RT DNA-binding properties of the product of the testis-determining gene and a RT related protein RL Nature 354:317-320 (1991). RN [2] RX MEDLINE; 90319094. RA Nasrin N., Ercolani L., Denaro M., Kong X. F., Kang I., Alexander M. RT An insulin response element in the glyceraldehyde-3-phosphate dehydrogenase RT gene binds to a nuclear protein induced by insulin in cultured cells and by RT nutritional manipulation in vivo RL Proc. Natl. Acad. Sci. USA 87:5273-5277 (1990). XX // AC G000263 XX ID HS$GAST XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD gastrin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17q XX BC 6.1.5.6 XX BS -163 -140 R04668; HS$GAST_03; Binding factors: Sp1 . BS -108 -82 R02031; HS$GAST_01. BS -68 -54 R03122; HS$GAST_02. XX DR EMBL: M15958; HSGASTA. DR TRANSPATH: G000263. DR LOCUSLINK: 2520. DR OMIM: 137250. DR REFSEQ: NM_000805. XX RN [1] RX MEDLINE; 95238378. RA Chung D. C., Brand S. J., Tillotson L. G. RT Mutually exclusive interactions between factors binding to adjacent Sp1 and RT AT-rich elements regulate gastrin gene transcription in insulinoma cells RL J. Biol. Chem. 270:8829-8836 (1995). RN [2] RX MEDLINE; 91203889. RA Merchant J. L., Demediuk B., Brand S. J. RT A GC-rich element confers epidermal growth factor responsiveness to RT transcription from the gastrin promoter RL Mol. Cell. Biol. 11:2686-2696 (1991). RN [3] RX MEDLINE; 90256824. RA Wang T. C., Brand S. J. RT Islet Cell-specific Regulatory Domain in the Gastric Promoter Contains RT Adjacent Positive and Negative DNA Elements RL J. Biol. Chem. 265:8908-8914 (1990). XX // AC G000264 XX ID HS$GBP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GBP XX DE guanylate-binding protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.5 XX BS -216 -76 R02897; HS$GBP_01; Binding factors: IRF1 , ISGF-1 BS . BS -128 -99 R03064; HS$GBP_02; Binding factors: GAF , AAF BS . XX DR TRANSPATH: G000264. DR TRRD: 00200. XX RN [1] RX MEDLINE; 91184139. RA Decker T., Lew D. J., Mirkowitch J., Darnell J. E. RT Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor RL EMBO J. 10:927-932 (1991). RN [2] RX MEDLINE; 92017789. RA Decker T., Lew D. J., Darnell J. E. RT Two distinct alpha-interferon-dependent signal transduction pathways may RT contribute to activation of transcription of the guanylate-binding protein RT gene RL Mol. Cell. Biol. 11:5147-5153 (1991). RN [3] RX MEDLINE; 91094830. RA Lew D. J., Decker Th., Strehlow I., Darnell J. E. RT Overlapping elements in the guanylate-binding protein gene promoter mediate RT transcriptional induction by alpha and gamma interferon RL Mol. Cell. Biol. 11:182-191 (1991). XX // AC G000265 XX ID HS$A20 XX DT 21.05.1996 (created); ake. DT 27.05.2002 (updated); elf. CO Copyright (C), Biobase GmbH. XX SD A20 XX SY TNFAIP3; TNFA1P2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6q23-q25 XX BC 6.1.2.2.4 XX DR TRANSPATH: G000265. DR TRRD: 00034. DR LOCUSLINK: 7128. DR OMIM: 191163. DR REFSEQ: NM_006290. XX // AC G000266 XX ID HS$GFER XX DT 14.06.1995 (created); dbo. CO Copyright (C), Biobase GmbH. XX SD genomic fragment XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BS empty empty R03570; HS$GFER_01; Binding factors: ER-alpha . BS empty empty R03571; HS$GFER_02; Binding factors: ER-alpha . BS empty empty R03572; HS$GFER_03; Binding factors: ER-alpha . BS empty empty R03573; HS$GFER_04; Binding factors: ER-alpha . BS empty empty R03574; HS$GFER_05; Binding factors: ER-alpha . XX DR TRANSPATH: G000266. XX RN [1] RX MEDLINE; 91334113. RA Inoue S., Kondo S., Hashimoto M., Kondo T., Muramatsu M. RT Isolation of estrogen receptor-binding sites in human genomic DNA RL Nucleic Acids Res. 19:4091-4096 (1991). XX // AC G000267 XX ID HS$GFAP XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD GFAP XX DE glial fibrillary acidic protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17q21 XX BS -1636 -1614 R04124; HS$GFAP_03; Binding factors: NF-1 , Sp1 BS . BS -1596 -1543 R04125; HS$GFAP_04; Binding factors: AP-1 , BS AP-2alphaA , NF-1 , AP-2alphaB . BS -1596 -1543 R04126; HS$GFAP_05; Binding factors: AP-2alphaA , BS NF-1 , AP-2alphaB . BS -36 39 R03166; HS$GFAP_01; Binding factors: TFIID . BS -36 -16 R03167; HS$GFAP_02; Binding factors: TBP , TBP BS . XX DR EMBL: M67446; HSGFAPJ. DR TRANSPATH: G000267. DR LOCUSLINK: 2670. DR OMIM: 137780. DR REFSEQ: NM_002055. XX RN [1] RX MEDLINE; 92011655. RA Besnard F., Brenner M., Nakatani Y., Chao R., Purohit H. J., Freese E. RT Multiple interacting sites regulate astrocyte-specific transcription of the RT human gene for glial fibrillary acidic protein RL J. Biol. Chem. 266:18877-18883 (1991). RN [2] RX MEDLINE; 91043053. RA Nakatani Y., Horikoshi M., Brenner M., Yamamoto T., Besnard F., Roeder R. RA G., Freese E. RT A downstream initiation element required for efficient TATA box binding and RT in vitro function of TFIID RL Nature 348:86-88 (1990). XX // AC G000268 XX ID HS$GLUR XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GR XX DE glucocorticoid receptor XX SY GR-beta; GRbeta; GRL. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 5q31-q32 XX BC 6.1.2.2.4 XX BS -698 -676 R03301; HS$GLUR_01; Binding factors: GRF-1 . XX FA T00337; GR alpha. FA T01920; GR beta. XX DR EMBL: M69074; HSGR1. DR TRANSPATH: G000268. DR PATHODB: MR000032. DR LOCUSLINK: 2908. DR OMIM: 138040. DR REFSEQ: NM_000176. XX RN [1] RX MEDLINE; 91224961. RA LeClerc S., Xie B., Roy R., Govindan M. V. RT Purification of a human glucocorticoid receptor gene promoter-binding RT protein RL J. Biol. Chem. 266:8711-8719 (1991). RN [2] RX MEDLINE; 91373352. RA LeClerc S., Palaniswami R., Xie B., Govindan M. V. RT Molecular cloning and characterization of a factor that binds the human RT glucocorticoid receptor gene and represses its expression RL J. Biol. Chem. 266:17333-17340 (1991). XX // AC G000269 XX ID HS$GSTYA XX DT 21.05.1996 (created); ake. DT 21.05.1996 (updated); ake. CO Copyright (C), Biobase GmbH. XX SD GSTYA XX DE glutathione S-transferase Ya subunit XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.4.9.2 XX DR BRENDA: 2.5.1.18; Human. DR TRRD: 00265. XX // AC G000270 XX ID HS$GSTP1 XX DT 21.05.1996 (created); ake. DT 29.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD GSTP1 XX DE Glutathione S-Transferase pi XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11q13-qter XX BC 6.1.4.9.2 XX DR BRENDA: 2.5.1.18; Human. DR TRRD: 00030. DR LOCUSLINK: 2950. DR OMIM: 134660. DR REFSEQ: NM_000852. XX // AC G000271 XX ID HS$GHA XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GCA XX DE glycoprotein hormone alpha-subunit XX SY HCG. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6q14-q21 XX BC 6.1.5.3.1 XX BS -182 -141 R00590; HS$GHA_01. BS -174 -165 R02655; HS$GHA_08. BS -153 -137 R00591; HS$GHA_03; Binding factors: GR , GR alpha BS , GR beta . BS -148 -109 R00592; HS$GHA_02; Binding factors: ATF , ATF BS , c-Fos , c-Jun , CREB , CREB , BS CRE-BP1 , JunB , CREB , ATF3 , CREBbeta BS . BS -122 -89 R00593; HS$GHA_05; Binding factors: GR , GR alpha BS , GR beta . BS -120 -90 R02847; HS$GHA_09; Binding factors: JRF . BS -105 -80 R02848; HS$GHA_10; Binding factors: alpha-CBF . BS -99 -72 R00594; HS$GHA_06; Binding factors: NF-1 , NF-1 BS . BS -84 -62 R00595; HS$GHA_07; Binding factors: GR , GR alpha BS , GR beta . BS -22 -7 R03958; HS$GHA_11; Binding factors: ER-alpha , T3R BS , T3R-beta1 . XX DR EMBL: L05632; HSGLYHAS. DR EMBL: J03765; HSGPHA. DR EMBL: M30462; HSGPHAA. DR TRANSPATH: G000271. DR TRANSCOMPEL: C00026. DR TRANSCOMPEL: C00088. DR TRRD: 00056. DR LOCUSLINK: 1081. DR OMIM: 118850. DR REFSEQ: NM_000735. XX RN [1] RX MEDLINE; 94012790. RA Yarwood N. J., Gurr J. A., Sheppard M. C., Franklyn J. A. RT Estradiol modulates thyroid hormone regulation of the human glycoprotein RT hormone alpha subunit gene RL J. Biol. Chem. 268:21984-21989 (1993). RN [2] RX MEDLINE; 92371441. RA Nichols M., Weih F., Schmid W., DeVack C., Kowenz-Leutz E., Luckow B., RA Boshart M., Schuetz G. RT Phosphorylation of CREB affects its binding to high and low affinity sites: RT implications for cAMP induced gene transcription RL EMBO J. 11:3337-3346 (1992). RN [3] RX MEDLINE; 92385426. RA Stauber C., Altschmied J., Akerblom I. E., Marron J. L., Mellon P. L. RT Mutual cross-interference between glucocorticoid receptor and CREB inhibits RT transactivation in placental cells RL New Biol. 4:527-540 (1992). RN [4] RX MEDLINE; 91304434. RA Albanese C., Kay T. W. H., Troccoli N. M., Jameson J. L. RT Novel cyclic adenosine 3',5'-monophosphate response element in the human RT chorionic gonadotropin beta-subunit gene RL Mol. Endocrinol. 5:693-702 (1991). RN [5] RX MEDLINE; 91219401. RA Hsu J. C., Laz T., Mohn K. L., Taub R. RT Identification of LRF-1, a leucine-zipper protein that is rapidly and RT highly induced in regenerating liver RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991). RN [6] RX MEDLINE; 91072394. RA Andersen B., Kennedy G. C., Nilson J. H. RT A cis-acting element located between the cAMP response elements and CCAAT RT box augments cell-specific expression of the glycoprotein hormone RT alpha-subunit gene RL J. Biol. Chem. 265:21874-21880 (1990). RN [7] RX MEDLINE; 90205810. RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H. RT A cDNA for a human cyclic AMP response element-binding protein which is RT distinct from CREB and expressed preferentially in brain RL Mol. Cell. Biol. 10:1347-1357 (1990). RN [8] RX MEDLINE; 91125364. RA Andersen B., Kennedy G. C., Hamernik D. L., Bokar J. A., Bohinski R., RA Nilson J. H. RT Amplification of the transcriptional signal mediated by the tandem cAMP RT response elements of the glycoprotein hormone alpha-subunit gene occurs RT through several distinct mechanisms RL Mol. Endocrinol. 4:573-582 (1990). RN [9] RX MEDLINE; 90191714. RA Benbrook D. M., Jones N. C. RT Heterodimer formation between CREB and JUN proteins RL Oncogene 5:295-302 (1990). RN [10] RX MEDLINE; 89098860. RA Lin Y.-S., Green M. R. RT Identification and purification of a Saccharomyces cerevisiae protein with RT the DNA binding specificity of mammalian activating transcription factor RL Proc. Natl. Acad. Sci. USA 86:109-113 (1989). RN [11] RX MEDLINE; 89380222. RA Jameson J. L., Albanese C., Habener J. F. RT Distinct Adjacent Protein-binding Domains in the Glycoprotein Hormone alpha RT Gene Interact Independently wit a cAMP-responsive Enhancer RL J. Biol. Chem. 264:16190-16196 (1989). RN [12] RX MEDLINE; 90097928. RA Bokar J. A., Keri R. A., Farmerie T. A., Fenstermaker R. A., Andersen B., RA Hamernik D. L., Yun J., Wagner T., Nilson J. H. RT Expression of the Glycoprotein Hormone alpha-Subunit Gene in the Placenta RT Requires a Functional Cyclic AMP Response Element, whereas a Different RT cis-Acting Element Mediates Pituitary-Specific Expression RL Mol. Cell. Biol. 9:5113-5122 (1989). RN [13] RX MEDLINE; 90083218. RA Chatterjee K., Lee J.-K., Rentoumis A., Jameson J. L. RT Negative regulation of the thyroid-stimulating hormone alpha gene by RT thyroid hormone: receptor interaction adjacent to the TATA box RL Proc. Natl. Acad. Sci. USA 86:9114-9118 (1989). RN [14] RX MEDLINE; 89107989. RA Sassone-Corsi P., Visvader J., Ferland L., Mellon P. L., Verma I. M. RT Induction of proto-oncogene fos transcription through the adenylate cyclase RT pathway: characterization of a cAMP-responsive element RL Genes Dev. 2:1529-1538 (1988). RN [15] RX MEDLINE; 88257120. RA Jameson J. L., Jaffe R. C., Deutsch P. J., Albanese C., Habener J. F. RT The Gonadotropin alpha-Gene Contains Multiple Protein Binding Domains That RT Interact to Modulate Basal and cAMP-responsive Transcription RL J. Biol. Chem. 263:9879-9886 (1988). RN [16] RX MEDLINE; 89066806. RA Bokar J. A., Roesler W. J., Vandenbark G. R., Kaetzel D. M., Hanson R. W., RA Nilson J. H. RT Characterization of the cAMP Responsive Elements from the Genes for the RT alpha-Subunit of Glycoprotein Hormones and Phosphoenolpyruvate RT Carboxykinase (GTP) RL J. Biol. Chem. 263:19740-19747 (1988). RN [17] RX MEDLINE; 89054030. RA Deutsch P. J., Hoeffler J. P., Jameson J. L., Lin J. C., Habener J. F. RT Structural determinants for transcriptional activation by cAMP-responsive RT DNA elements RL J. Biol. Chem. 263:18466-18472 (1988). RN [18] RX MEDLINE; 88217908. RA Lin Y.-S., Green M. R. RT Interaction of a common cellular transcription factor, ATF, with regulatory RT elements in both E1a- and cyclic AMP-inducible promoters RL Proc. Natl. Acad. Sci. USA 85:3396-3400 (1988). RN [19] RX MEDLINE; 88264449. RA Akerblom I., Slater E. P., Beato M., Baxter J. D., Mellon P. L. RT Negative regulation by glucocorticoids through interference with a cAMP RT responsive enhancer RL Science 241:350-353 (1988). RN [20] RX MEDLINE; 88122122. RA Delegeane A. M., Ferland L. H., Mellon P. L. RT Tissue-Specific Enhancer of the Human Glycoprotein Hormone alpha-Subunit RT Gene: Dependence on the Cyclic AMP-Inducible Elements RL Mol. Cell. Biol. 7:3994-4002 (1987). XX // AC G000272 XX ID HS$GMCSF XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GM-CSF XX DE granulocyte/macrophage colony stimulating factor XX SY CSF1; GMCSF. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 5q23-q31 XX BC 6.1.5.9 XX BS empty empty R05032; HS$GMCSF_07; Binding factors: PEBP2beta , BS PEBP2alpha . BS -95 -75 R00601; HS$GMCSF_01; Binding factors: NF-GMa , NF-GMb BS . BS -95 -75 R00602; HS$GMCSF_02; Binding factors: CD28RC , NF-GMa BS . BS -72 -43 R05031; HS$GMCSF_06; Binding factors: PEBP2beta , BS PEBP2alpha . BS -64 -35 R04957; HS$GMCSF_05; Binding factors: AP-1 , YY1 BS . BS -59 -36 R05033; HS$GMCSF_08; Binding factors: AP-1 , c-Fos BS , c-Jun . BS -57 -24 R00603; HS$GMCSF_03; Binding factors: YY1 . BS -54 -31 R05034; HS$GMCSF_09; Binding factors: NFAT-1 , NF-ATp BS . BS -52 -34 R00604; HS$GMCSF_04. BS 164 194 R05093; HS$GMCSF_16; Binding factors: AP-1 , c-Fos BS , c-Jun . BS 164 194 R05094; HS$GMCSF_17; Binding factors: NF-ATp , NF-ATp BS . BS 317 344 R05082; HS$GMCSF_10; Binding factors: NF-ATp , NF-ATp BS . BS 317 344 R05083; HS$GMCSF_11; Binding factors: AP-1 , c-Fos BS , c-Jun . BS 413 443 R05089; HS$GMCSF_12; Binding factors: AP-1 , c-Fos BS , c-Jun . BS 413 443 R05090; HS$GMCSF_13; Binding factors: NF-ATp , NF-ATp BS . BS 539 568 R05091; HS$GMCSF_14; Binding factors: AP-1 , c-Fos BS , c-Jun . BS 539 568 R05092; HS$GMCSF_15; Binding factors: NF-ATp , NF-ATp BS . XX DR EMBL: L07488; HSENHANCE. DR EMBL: X03021; HSGMCSFG. DR TRANSPATH: G000272. DR TRANSCOMPEL: C00141. DR TRANSCOMPEL: C00142. DR TRANSCOMPEL: C00143. DR TRANSCOMPEL: C00164. DR TRANSCOMPEL: C00262. DR TRANSCOMPEL: C00344. DR TRANSCOMPEL: C00352. DR TRANSCOMPEL: C00353. DR LOCUSLINK: 1437. DR OMIM: 138960. DR REFSEQ: NM_000758. XX RN [1] RX MEDLINE; 96104565. RA Ye J., Zhang X., Dong Z. RT Characterization of the human granulocyte-macrophage colony-stimulating RT factor gene promoter: an AP1 complex and an Sp1-related complex RT transactivate the promoter activity that is suppresed by a YY1 complex RL Mol. Cell. Biol. 16:157-167 (1996). RN [2] RX MEDLINE; 96405269. RA Cockerill P. N., Osborne C. S., Bert A. G., Grotto R. J. M. RT Regulation of GM-CSF gene transcription by core-binding factor RL Cell Growth Differ. 7:917-922 (1996). RN [3] RX MEDLINE; 95363089. RA Jenkins F., Cockerill P. N., Bohmann D., Shannon M. F. RT Multiple signals are required for function of the human granulocyte- RT macrophage colony-stimulating factor gene promoter in T cells RL J. Immunol. 155:1240-1251 (1995). RN [4] RX MEDLINE; 95198726. RA Cockerill P. N., Bert A. G., Jenkins F., Ryan G. R., Shannon M. F., Vadas RA M.A. RT Human granulocyte-macrophage colony-stimulating factor enhancer function is RT associated with cooperative interactions between AP-1 and NFATp/c RL Mol. Cell. Biol. 15:2071-2079 (1995). RN [5] RX MEDLINE; 95140631. RA Ye J., Young H. A., Ortaldo J. R., Ghosh P. RT Identification of a DNA binding site for the nuclear factor YY1 in the RT human GM-CSF core promoter RL Nucleic Acids Res. 22:5672-5678 (1994). RN [6] RX MEDLINE; 93024377. RA Fraser J. D., Weiss A. RT Regulation of T-cell lymphokine gene transcription by the accessory RT molecule CD28 RL Mol. Cell. Biol. 12:4357-4363 (1992). RN [7] RX MEDLINE; 90258885. RA Shannon M. F., Pell L. M., Lenardo M. J., Kuczek E. S., Occhiodoro F. S., RA Dunn St. M., Vadas M. A. RT A Novel Tumor Necrosis Factor-Responsive Transcription Factor Which RT Recognizes a Regulatory Element in Hemopoietic Growth Factor Genes RL Mol. Cell. Biol. 10:2950-2959 (1990). RN [8] RX MEDLINE; 88261273. RA Nimer S. D., Morita E. A., Martis M. J., Wachsman W., Gasson J. C. RT Characterization of the Human Granulocyte-Macrophage Colony-Stimulating RT Factor Promoter Region by Genetic Analysis: Correlation with DNase I RT Footprinting RL Mol. Cell. Biol. 8:1979-1984 (1988). RN [9] RX MEDLINE; 88124904. RA Shannon M. F., Gamble J. R., Vadas M. A. RT Nuclear proteins interacting with the promoter region of the human RT granulocyte/macrophage colony-stimulating factor gene RL Proc. Natl. Acad. Sci. USA 85:674-678 (1988). XX // AC G000274 XX ID HS$CYBH XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD gp91-phox XX DE cytochrome b heavy chain XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH Xp21.1 XX BC 6.1.4.9 XX BS -137 -86 R03477; HS$CYBH_01; Binding factors: CUTL1 , CP1 BS , Clox , Cutl1 , CDP2 . XX DR EMBL: M66390; HSGP91. DR TRANSPATH: G000274. DR TRANSCOMPEL: C00249. DR LOCUSLINK: 1536. DR OMIM: 306400. DR REFSEQ: NM_000397. XX RN [1] RX MEDLINE; 94329595. RA Aufiero B., Neufeld E. J., Orkin S. H. RT Sequence-specific DNA binding of individual cut repeats of the human CCAAT RT displacement/ cut homeodomain protein RL Proc. Natl. Acad. Sci. USA 91:7757-7761 (1994). RN [2] RX MEDLINE; 91358470. RA Skalnik D. G., Strauss E. C., Orkin S. H. RT CCAAT displacement protein as a repressor of the myelomonocytic-specific RT gp91-phox gene promoter RL J. Biol. Chem. 266:16736-16744 (1991). XX // AC G000275 XX ID HS$GPB XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD GPB XX DE glycophorin B XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q28-q31 XX BC 6.1.6.5.6 XX BS -134 -129 R08210; HS$GPB_05; Binding factors: GATA-1 . BS -87 -65 R08209; HS$GPB_04; Binding factors: GATA-1 . BS -66 -60 R08208; HS$GPB_03. BS -53 -48 R08207; HS$GPB_02; Binding factors: Sp1 . BS -41 -34 R03268; HS$GPB_01; Binding factors: GATA-1 , GATA-3 BS . XX DR EMBL: M57233; HSGPBA. DR TRANSPATH: G000275. DR TRRD: 00321. DR LOCUSLINK: 2994. DR OMIM: 111740. DR REFSEQ: NM_002100. XX RN [1] RA Rahuel C., Vinit M.-A., Lemarchandel V., Cartron J.-P., Romeo P.-H. RT Erythroid-specific activity of the glycophorin B promoter requires GATA-1 RT mediated displacement of a repressor RL EMBO J. 11:4095-4102 (1992). RN [2] RX MEDLINE; 91266910. RA Joulin V., Bouries D., Eleouet J.-F., Labastie M.-C., Chretien S., Mattei RA M.-G., Romeo P.-H. RT A t-cell specific TCR delta DNA binding protein is a member of the human RT GATA family RL EMBO J. 10:1809-1816 (1991). XX // AC G000276 XX ID HS$GPC XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GPC XX DE glycophorin C XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 2q14-q21 XX BC 6.1.6.5.6 XX BS -216 -195 R02441; HS$GPC_01; Binding factors: NFE-6 . BS -182 -175 R02442; HS$GPC_02; Binding factors: GATA-1 . BS -170 -160 R02443; HS$GPC_03; Binding factors: GATA-1 . BS -105 -85 R02444; HS$GPC_04; Binding factors: Sp1 . BS -67 -57 R02445; HS$GPC_05. BS -21 -7 R02447; HS$GPC_07; Binding factors: GATA-1 . BS 5 15 R02446; HS$GPC_06; Binding factors: Sp1 . XX DR EMBL: X14242; HSGYPC. DR TRANSPATH: G000276. DR TRRD: 00322. DR LOCUSLINK: 2995. DR OMIM: 110750. DR REFSEQ: NM_016815. XX RN [1] RX MEDLINE; 91009082. RA Colin Y., Joulin V., Le Van Kim C., Romeo P.-H., Cartron J.-P. RT Characterization of a new erythroid/megacaryocyte-specific nuclear factor RT that binds the promoter of the housekeeping human glycophorin C gene RL J. Biol. Chem. 265:16729-16732 (1990). XX // AC G000277 XX ID HS$GP2B XX DT 14.06.1995 (created); dbo. DT 16.03.1999 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GPIIb XX DE platelet glycoprotein IIb XX SY APOH; CD41B; GP2B. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17q21.32 XX BS -562 -530 R03302; HS$GP2B_09; Binding factors: HNF-1A , HNF-1B BS , HNF-1C . BS -524 -502 R03303; HS$GP2B_10. BS -476 -456 R03304; HS$GP2B_11; Binding factors: GATA-1 . BS -381 -372 R08205; HS$GP2B_14; Binding factors: GATA-1 . BS -362 -338 R03305; HS$GP2B_12; Binding factors: HNF-1A , HNF-1B BS , HNF-1C . BS -249 -240 R08206; HS$GP2B_15; Binding factors: GATA-1 . BS -243 -220 R03306; HS$GP2B_13. BS -145 0 R00596; HS$GP2B_01; Binding factors: CACCC-binding factor BS . BS -69 -39 R01710; HS$GP2B_05; Binding factors: GATA-1 . BS -48 -24 R01711; HS$GP2B_06; Binding factors: c-Ets-1 68 , PU.1 BS , Fli-1 , PU.1 . BS -15 0 R01712; HS$GP2B_07. XX DR EMBL: M22568; HSGP2B1. DR EMBL: M33319; HSGPIIB1. DR TRANSPATH: G000277. DR LOCUSLINK: 3674. DR OMIM: 273800. DR REFSEQ: NM_000419. XX RN [1] RX MEDLINE; 93275657. RA Zhang L., Lemarchandel V., Romeo P.-H., Ben-David Y., Greer P., Bernstein A. RT The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing`s sarcoma, RT encodes a transcriptional activator with DNA-binding specifities distinct RT from other Ets family members RL Oncogene 8:1621-1630 (1993). RN [2] RA Martin F., Prandini M.-H., Thevenon D., Marguerie G., Uzan G. RT The transcription factor GATA-1 regulates the promoter activity of the RT platelet glycoprotein IIb gene RL J. Biol. Chem. 268:21606-21612 (1993). RN [3] RX MEDLINE; 91224990. RA Uzan G., Prenant M., Prandini M.-H., Martin F., Marguerie G. RT Tissue-specific expression of the platelet GPIIb gene RL J. Biol. Chem. 266:8932-8939 (1991). RN [4] RX MEDLINE; 90206049. RA Romeo P.-H., Prandini M.-H., Joulin V., Mignotte V., Prenant M., RA Vainchenker W., Marguerie G., Uzan G. RT Megakaryocytic and erythrocytic lineages share specific transcription RT factors RL Nature 344:447-449 (1990). RN [5] RX MEDLINE; 90206049. RA Romeo P.-H., Prandini M.-H., Joulin V., Mignotte V., Prenant M., RA Vainchenker W., Marguerie G., Uzan G. RT Megakaryocytic and erythrocytic lineages share specific transcription RT factors RL Nature 344:447-449 (1990). XX // AC G000279 XX ID HS$GRO1 XX DT 14.06.1995 (created); dbo. DT 28.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD GRO1 XX DE melanoma growth stimulating activity, alpha XX SY GRO; SCYB1; MGSA; MGSA/GRO-alpha. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q21 XX BC 6.1.5.10 XX BS -130 -116 R04930; HS$GROA_02; Binding factors: Sp1 , Sp3 BS , Sp3 . BS -97 -62 R04931; HS$GROA_03; Binding factors: HMG I(Y) . BS -77 -57 R03340; HS$GROA_01; Binding factors: NF-kappaB . XX DR EMBL: U03018; HS03018. DR EMBL: M65005; HSGROAL. DR TRANSPATH: G000279. DR TRANSCOMPEL: C00140. DR TRRD: 00066. DR LOCUSLINK: 2919. DR OMIM: 155730. DR REFSEQ: NM_001511. XX RN [1] RX MEDLINE; 96071185. RA Wood L. D., Farmer A. A., Richmond A. RT HMGI(Y) and Sp1 in addition to NF-kappaB regulate transcription of the RT MGSA/GROalpha gene RL Nucleic Acids Res. 23:4210-4219 (1995). RN [2] RX MEDLINE; 91302798. RA Anisowicz A., Messineo M., Lee S. W., Sager R. RT An NF-kappaB-like transcription factor mediates IL-1/TNF-alpha induction of RT gro in human fibroblasts RL J. Immunol. 147:520-527 (1991). XX // AC G000280 XX ID HS$GRO2 XX DT 14.06.1995 (created); dbo. DT 28.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD GRO2 XX SY SCYB2; MIP2a; GROB; GRO-beta; melanoma growth-stimulating activity beta. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q21 XX BC 6.1.5.10 XX BS -77 -57 R03341; HS$GROB_01; Binding factors: NF-kappaB . XX DR EMBL: M65006; HSGROBE. DR TRANSPATH: G000280. DR TRRD: 00067. DR LOCUSLINK: 2920. DR OMIM: 139110. DR REFSEQ: NM_002089. XX RN [1] RX MEDLINE; 91302798. RA Anisowicz A., Messineo M., Lee S. W., Sager R. RT An NF-kappaB-like transcription factor mediates IL-1/TNF-alpha induction of RT gro in human fibroblasts RL J. Immunol. 147:520-527 (1991). XX // AC G000281 XX ID HS$GRO3 XX DT 14.06.1995 (created); dbo. DT 28.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD GRO3 XX SY SCYB2; MIP2a; GROG; GRO-gamma; melanoma growth-stimulating activity gamma. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q21 XX BC 6.1.5.10 XX BS -77 -57 R03342; HS$GROG_01; Binding factors: NF-kappaB . XX DR EMBL: M65006; HSGROBE. DR TRANSPATH: G000281. DR TRRD: 00068. DR LOCUSLINK: 2921. DR OMIM: 139111. DR REFSEQ: NM_002090. XX RN [1] RX MEDLINE; 91302798. RA Anisowicz A., Messineo M., Lee S. W., Sager R. RT An NF-kappaB-like transcription factor mediates IL-1/TNF-alpha induction of RT gro in human fibroblasts RL J. Immunol. 147:520-527 (1991). XX // AC G000282 XX ID HS$GRH XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GH XX DE growth hormone gene-1 XX SY GH-N. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17q22-q24 XX BC 6.1.5.3.2 XX BS -290 -254 R00607; HS$GRH_01; Binding factors: AP-2 , AP-2alphaA BS , NF-1 , NF-1 , AP-2alphaB . BS -167 -145 R00608; HS$GRH_02; Binding factors: AP-2alphaA , BS AP-2alphaB . BS -140 -106 R00609; HS$GRH_03; Binding factors: POU1F1a . BS -139 -115 R00610; HS$GRH_04; Binding factors: Sp1 , Sp1 BS . BS -132 -105 R00611; HS$GRH_05; Binding factors: POU1F1 , POU1F1a BS , POU1F1b , POU1F1c . BS -93 -65 R00612; HS$GRH_06; Binding factors: POU1F1 , POU1F1a BS , POU1F1b , POU1F1c . BS 90 120 R00613; HS$GRH_07; Binding factors: GR . XX DR EMBL: M13438; HSGHN. DR TRANSPATH: G000282. DR TRANSCOMPEL: C00038. DR TRANSCOMPEL: C00046. DR TRRD: 00070. DR LOCUSLINK: 2688. DR OMIM: 139250. DR REFSEQ: NM_000515. XX RN [1] RX MEDLINE; 92289691. RA Theill L. E., Hattori K., Lazzaro D., Castrillo J.-L., Karin M. RT Differential splicing of the GHF1 primary transcript gives rise to two RT functionally distinct homeodomain proteins RL EMBO J. 11:2261-2269 (1992). RN [2] RX MEDLINE; 91236760. RA Tansey W. P., Catanzaro D. F. RT Sp1 and thyroid hormone receptor differentially activate expression of RT human growth hormone and chorionic somatomammotropin genes RL J. Biol. Chem. 266:9805-9813 (1991). RN [3] RX MEDLINE; 90205866. RA Lemaigre F. P., Lafontaine D. A., Courtois S. J., Durviaux S. M., Rousseau RA G. G. RT Sp1 can displace GHF-1 from its distal binding site and stimulate RT transcription from the growth hormone gene promoter RL Mol. Cell. Biol. 10:1811-1814 (1990). RN [4] RX MEDLINE; 90174951. RA Courtois S. J., Lafontaine D. A., Lemaigre F. P., Durviaux S. M., Rousseau RA G. G. RT Nuclear factor-I and activator protein-2 bind in a mutually exclusive way RT to overlapping promoter sequences and trans-activate the human growth RT hormone gene RL Nucleic Acids Res. 18:57-64 (1990). RN [5] RX MEDLINE; 90081880. RA Theill L. E., Castrillo J.-L., Wu D., Karin M. RT Dissection of functional domains of the pituitary-specific transcription RT factor GHF-1 RL Nature 342:945-948 (1989). RN [6] RX MEDLINE; 89028660. RA Bodner M., Castrillo J.-L., Theill L. E., Deerinck T., Ellisman M., Karin M. RT The Pituitary-Specific Transcription Factor GHF-1 Is a Homeobox-Containing RT Protein RL Cell 55:505-518 (1988). RN [7] RX MEDLINE; 89003076. RA McCormick A., Wu D., Castrillo J.-L., Dana S., Strobl J., Thompson E. B., RA Karin M. RT Extinction of growth hormone expression in somatic cell hybrids involves RT repression of the specific trans-activator GHF-1 RL Cell 55:379-389 (1988). RN [8] RX MEDLINE; 88027009. RA Imagawa M., Chiu R., Karin M. RT Transcription factor AP-2 mediates induction by two different signal RT transduction pathways: Protein kinase C and cAMP RL Cell 51:251-260 (1987). RN [9] RX MEDLINE; 87244342. RA Bodner M., Karin M. RT A Pituitary-Specific Trans-Acting Factor Can Stimulate Transcription from RT the Growth Hormone Promoter in Extracts of Nonexpressing Cells RL Cell 50:267-275 (1987). RN [10] RX MEDLINE; 87246534. RA Lefevre C., Imagawa M., Dana S., Grindlay J., Bodner M., Karin M. RT Tissue-specific expression of the human growth hormone gene is conferred in RT part by the binding of a specific trans-acting factor RL EMBO J. 6:971-981 (1987). RN [11] RX MEDLINE; 85140164. RA Moore D. D., Marks A. R., Buckley D. I., Kapler G., Payvar F., Goodman H. M. RT The first intron of the human growth hormone gene contains a binding site RT for glucocorticoid receptor RL Proc. Natl. Acad. Sci. USA 82:699-702 (1985). XX // AC G000283 XX ID HS$GRP78 XX DT 14.06.1995 (created); dbo. DT 28.05.2002 (updated); elf. CO Copyright (C), Biobase GmbH. XX SD GRP78 XX DE glucose-regulated protein 78 XX SY BiP; HSPA5; MIF2; Heat-shock 70kD protein-5 (glucose-regulated protein, SY 78kD). XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 9q33-q34.1 XX BS -203 -161 R00588; HS$GRP78_04. BS -170 -135 R00585; HS$GRP78_01. BS -160 -101 R00586; HS$GRP78_02. XX DR TRANSPATH: G000283. DR LOCUSLINK: 3309. DR OMIM: 138120. DR REFSEQ: NM_005347. XX RN [1] RX MEDLINE; 92020237. RA Liu E. S., Lee A. S. RT Common sets of nuclear factors binding to the conserved promoter sequence RT motif of two coordinately regulated ER protein genes, GRP78 and GRP94 RL Nucleic Acids Res. 19:5425-5431 (1991). RN [2] RX MEDLINE; 89313762. RA Chang S. C., Erwin A. E., Lee A. S. RT Glucose-Regulated Protein (GRP94 and GRP78) Genes Share Common Regulatory RT Domains and Are Coordinately Regulated by Common trans-Acting Factors RL Mol. Cell. Biol. 9:2153-2162 (1989). RN [3] RX MEDLINE; 89039896. RA Resendez jr E., Wooden S. K., Lee A. S. RT Identification of Highly Conserved Regulatory Domains and Protein-Binding RT Sites in the Promoters of the Rat and Human Genes Encoding the RT Stress-Inducible 78-Kilodalton Glucose-Regulated Protein RL Mol. Cell. Biol. 8:4579-4584 (1988). XX // AC G000285 XX ID HS$HPG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HPG XX DE haptoglobin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 16q22.1 XX BC 6.1.3.13 XX BS -171 -157 R00627; HS$HPG_01; Binding factors: C/EBPalpha . BS -120 -102 R00628; HS$HPG_02. BS -70 -57 R00629; HS$HPG_03; Binding factors: C/EBPalpha , BS C/EBPdelta . XX DR EMBL: X01793; HSHP1G1. DR EMBL: X01794; HSHPRG1. DR TRANSPATH: G000285. DR TRRD: 00188. DR LOCUSLINK: 3240. DR OMIM: 140100. DR REFSEQ: NM_005143. XX RN [1] RX MEDLINE; 93181204. RA Ramji D. P., Vitelli A., Tronche F., Cortese R., Ciliberto G. RT The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are RT induced by IL-6 to promote acute phase gene transcription via different RT mechanisms RL Nucleic Acids Res. 21:289-294 (1993). RN [2] RX MEDLINE; 91029495. RA Poli V., Mancini F. P., Cortese R. RT IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, RT defines a new family of leucine zipper proteins related to C/EBP RL Cell 63:643-653 (1990). RN [3] RX MEDLINE; 89305516. RA Oliviero S., Cortese R. RT The human haptoglobin gene promoter: interleukin-6-responsive elements RT interact with a DNA-binding protein induced by interleukin-6 RL EMBO J. 8:1145-1151 (1989). XX // AC G000286 XX ID HS$HSP70 XX DT 14.06.1995 (created); dbo. DT 24.04.2001 (updated); sth. CO Copyright (C), Biobase GmbH. XX SD hsp70 XX DE heat shock protein 70 XX SY HSP70-1; HSPA1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.6.2 XX BS -283 -214 R00760; HS$HSP70_01. BS -207 -179 R04287; HS$HSP70_13; Binding factors: HSF1 (long) , BS HSF2 , HSF1 (short) . BS -176 -157 R01770; HS$HSP70_12; Binding factors: Sp1 . BS -158 -131 R00761; HS$HSP70_02; Binding factors: CTF . BS -112 -84 R00762; HS$HSP70_03; Binding factors: HSF , HSF BS , HSTF , HSF1 (long) , HSF2 , hsf , BS HSF1 (short) . BS -110 -78 R00763; HS$HSP70_04; Binding factors: HSF . BS -107 -83 R00764; HS$HSP70_05; Binding factors: HSF , HSF BS . BS -76 -52 R00765; HS$HSP70_06; Binding factors: CCAAT-binding factor BS . BS -74 -49 R00766; HS$HSP70_07; Binding factors: CP1 , CTF BS , CBTF . BS -68 -32 R00767; HS$HSP70_08. BS -67 -62 R00768; HS$HSP70_09; Binding factors: CP1 , CTF BS . BS -55 -38 R00769; HS$HSP70_10; Binding factors: Sp1 . BS -40 -19 R00770; HS$HSP70_11; Binding factors: TBP , TFIID BS . XX DR EMBL: X04676; HSHSP70A. DR EMBL: M11717; HSHSP70D. DR TRANSPATH: G000286. DR TRRD: 00102. DR LOCUSLINK: 3303. DR OMIM: 140550. DR REFSEQ: NM_005345. XX RN [1] RX MEDLINE; 93140772. RA Gallo G. J., Prentice H., Kingston R. E. RT Heat shock factor is required for growth at normal temperatures in the RT fission yeast Schizosaccharomyces pombe RL Mol. Cell. Biol. 13:749-761 (1993). RN [2] RX MEDLINE; 92235292. RA Benjamin I. J., Horie S., Greenberg M. L., Alpern R. J., Williams R. S. RT Induction of stress proteins in cultured myogenic cells RL J. Clin. Invest. 89:1685-1689 (1992). RN [3] RX MEDLINE; 92334348. RA Hosokawa N., Hirayoshi K., Kudo H., Takechi H., Aoike A., Kawai K., Nagata RA K. RT Inhibition of the activation of heat shock factor in vivo and in vitro by RT flavonoids RL Mol. Cell. Biol. 12:3490-3498 (1992). RN [4] RX MEDLINE; 92375079. RA Sistonen L., Sarge K. D., Phillips B., Abravaya K., Morimoto R. I. RT Activation of heat shock factor 2 during hemin-induced differentiation of RT human erythroleukemia cells RL Mol. Cell. Biol. 12:4104-4111 (1992). RN [5] RX MEDLINE; 91250012. RA Ovsenek N., Karn H. A., Heikkila J. J. RT Analysis of CCAAT box transcription factor binding activity during early RT Xenopus laevis embryogenesis RL Dev. Biol. 145:323-327 (1991). RN [6] RX MEDLINE; 91094879. RA Abravaya K., Phillips B., Morimoto R. I. RT Heat shock-induced interactions of heat shock transcription factor and the RT human hsp70 promoter examined by in vivo footprinting RL Mol. Cell. Biol. 11:586-592 (1991). RN [7] RX MEDLINE; 91260699. RA Cunniff N. F. A., Wagner J., Morgan W. D. RT Modular recognition of 5-base-pair DNA sequence motifs by human heat shock RT transcription factor RL Mol. Cell. Biol. 11:3504-3514 (1991). RN [8] RX MEDLINE; 91334377. RA Schuetz T. J., Gallo G. J., Sheldon L., Temps P., Kingston R. E. RT Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in RT humans RL Proc. Natl. Acad. Sci. USA 88:6911-6915 (1991). RN [9] RX MEDLINE; 92039000. RA Abravaya K., Phillips B., Morimoto R. I. RT Attenuation of the heat shock response in HeLa cells is mediated by the RT release of bound heat shock transcription factor and is modulated by RT changes in growth and in heat shock temperatures RL Genes Dev. 5:2117-2127 (1991). RN [10] RX MEDLINE; 90205840. RA Hensold J. O., Hunt C. R., Calderwood S. K., Housman D. E., Kingston R. E. RT DNA Binding of Heat Shock Factor to the Heat Shock Element Is Insufficient RT for Transcriptional Activation in Murine Erythroleukemia Cells RL Mol. Cell. Biol. 10:1600-1608 (1990). RN [11] RX MEDLINE; 90097825. RA Taylor I. C. A., Kingston R. E. RT Factor Substitution in a Human HSP70 Gene Promoter: TATA-Dependent and RT TATA-Independent Interactions RL Mol. Cell. Biol. 10:165-175 (1990). RN [12] RX MEDLINE; 91061780. RA Lum L. S. Y., Sultzman L. A., Kaufman R. J., Linzer D. L. H., Wu B. J. RT A cloned human CCAAT-box-binding factor stimulates transcription from the RT human hsp70 promoter RL Mol. Cell. Biol. 10:6709-6717 (1990). RN [13] RX MEDLINE; 90251634. RA Mosser D. D., Kotzbauer P. T., Sarge K. D., Morimoto R. I. RT In vitro activation of heat shock transcription factor DNA-binding by RT calcium and biochemical conditions that affect protein conformation RL Proc. Natl. Acad. Sci. USA 87:3748-3752 (1990). RN [14] RX MEDLINE; 90349595. RA Benjamin I. J., Kroeger B., Williams R. S. RT Activation of the heat shock transcription factor by hypoxia in mammalian RT cells RL Proc. Natl. Acad. Sci. USA 87:6263-6267 (1990). RN [15] RX MEDLINE; 90014769. RA Theodorakis N. G., Zand D. J., Kotzbauer P. T., Williams G. T., Morimoto R. RA I. RT Hemin-Induced Transcriptional Activation of the HSP70 Gene during Erythroid RT Maturation in K562 Cells Is Due to a Heat Shock Factor-Mediated Stress RT Response RL Mol. Cell. Biol. 9:3166-3173 (1989). RN [16] RX MEDLINE; 89384647. RA Morgan W. D. RT Transcriptional Factor Sp1 Binds to and Activates a Human hsp70 Gene RT Promoter RL Mol. Cell. Biol. 9:4099-4104 (1989). RN [17] RX MEDLINE; 89296458. RA Harel-Bellan A., Brini A. T., Ferris D. K., Robin P., Farrar W. L. RT In situ detection of a heat-shock regulatory element binding protein using RT a soluble short synthetic enhancer sequence RL Nucleic Acids Res. 17:4077-4087 (1989). RN [18] RX MEDLINE; 89039826. RA Nakajima N., Horikoshi M., Roeder R. G. RT Factors Involved in Specific Transcription by Mammalian RNA Polymerase II: RT Purification, Gene Specificity, and TATA Box-Promoter Interactions of TFIID RL Mol. Cell. Biol. 8:4028-4040 (1988). RN [19] RX MEDLINE; 89096845. RA Mosser D. D., Theodorakis N. G., Morimoto R. I. RT Coordinate Changes in Heat Shock Element-Binding Acitvity and HSP70 Gene RT Transcription Rates in Human Cells RL Mol. Cell. Biol. 8:4736-4744 (1988). RN [20] RX MEDLINE; 88334705. RA Larson J. S., Schuetz T. J., Kingston R. E. RT Activation in vitro of sequence-specific DNA binding by a human regulatory RT factor RL Nature 335:372-375 (1988). RN [21] RX MEDLINE; 89071721. RA Visvader J., Sassone-Corsi P., Verma I. RT Two adjacent promoter elements mediate nerve growth factor activation of RT the c-fos gene and bind distinct nuclear complexes RL Proc. Natl. Acad. Sci. USA 85:9474-9478 (1988). RN [22] RX MEDLINE; 88065503. RA Greene J. M., Larin Z., Taylor I. C. A., Prentice H., Gwinn K. A., Kingston RA R. E. RT Multiple Basal Elements of a Human hsp70 Promoter Function Differently in RT Human and Rodent Cell Lines RL Mol. Cell. Biol. 7:3646-3655 (1987). RN [23] RX MEDLINE; 87172780. RA Morgan W. D., Williams G. T., Morimoto R. I., Greene J., Kingston R. E., RA Tjian R. RT Two transcriptional activators, CCAAT-box-binding transcription factor and RT heat shock transcription factor, interact with a human hsp70 gene promoter RL Mol. Cell. Biol. 7:1129-1138 (1987). RN [24] RX MEDLINE; 87257843. RA Kingston R. E., Schuetz T. J., Larin Z. RT Heat-Inducible Human Factor That Binds to a Human hsp70 Promoter RL Mol. Cell. Biol. 7:1530-1534 (1987). RN [25] RX MEDLINE; 87175642. RA Wu B. J., Williams G. T., Morimoto R. I. RT Detection of three protein binding sites in the serum-regulated promoter of RT the human gene encoding the 70-kDa heat shock protein RL Proc. Natl. Acad. Sci. USA 84:2203-2207 (1987). XX // AC G000287 XX ID HS$HO XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD HO XX DE heme oxygenase XX SY HO1; bK286B10. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 22q12 XX BC 6.1.4.4 XX BS -157 -147 R04571; HS$HO_02; Binding factors: MTB-Zf . BS -50 -33 R00642; HS$HO_01; Binding factors: USF1 . XX DR EMBL: X14782; HSHO5G. DR TRANSPATH: G000287. DR BRENDA: 1.14.99.3; Human. DR LOCUSLINK: 3162. DR OMIM: 141250. DR REFSEQ: NM_002133. XX RN [1] RX MEDLINE; 96184519. RA Muraosa Y., Takahashi K., Yoshizawa M., Shibahara S. RT cDNA cloning of a novel protein containing two zinc-finger domains that may RT function as a transcription factor for the human heme- oxygenase-1 gene RL Eur. J. Biochem. 235:471-479 (1996). RN [2] RX MEDLINE; 90201047. RA Sato M., Ishizawa S., Yoshida T., Shibahara S. RT Interaction of upstream stimulatory factor with the human heme oxygenase RT gene RL Eur. J. Biochem. 188:231-237 (1990). XX // AC G000288 XX ID HS$LIPC XX DT 21.05.1996 (created); ake. DT 29.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD LIPC XX DE lipase, hepatic XX SY hepatic triglyceride lipase; lipase C precursor. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 15q21-q23 XX BC 6.1.4.6 XX DR BRENDA: 3.1.1.3; Human. DR TRRD: 00091. DR LOCUSLINK: 3990. DR OMIM: 151670. DR REFSEQ: NM_000236. XX // AC G000289 XX ID HS$FCGR1 XX DT 21.05.1996 (created); ake. DT 18.09.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Fc gamma RI (CD64) XX DE high affinity IgG receptor XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.5.15 XX BS -35 -16 R11115; HS$FCGR1_01; Binding factors: STAT6 , STAT5A BS , STAT1 , STAT5B . XX DR EMBL: M82819; HSHAIGGR. DR TRANSPATH: G000289. DR TRRD: 00199. XX RN [1] RX MEDLINE; 21125882. RA Ehret G. B., Reichenbach P., Schindler U., Horvath C. M., Fritz S., Nabholz RA M., Bucher P. RT DNA binding specificity of different STAT proteins. Comparison of in vitro RT specificity with natural target sites. RL J. Biol. Chem. 276:6675-6688 (2001). XX // AC G000290 XX ID HS$HH1 XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H1 XX DE histone 1 XX SY H1.5. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.2.1.1 XX BS -200 -160 R00658; HS$HH1_01; Binding factors: HiNF-A . BS -122 -90 R00659; HS$HH1_02; Binding factors: HiNF-B , H1TF1 BS . BS -55 -34 R00660; HS$HH1_03; Binding factors: H1TF2 . XX DR EMBL: X06757; HSH1FNC1. DR EMBL: M60747; HSHISAB. DR EMBL: M60748; HSHISAC. DR TRANSPATH: G000290. DR TRRD: 00096. XX RN [1] RX MEDLINE; 90152342. RA La Bella F., Gallinari P., McKinney J., Heintz N. RT Histone H1 subtype-specific consensus element mediate cell cycle-regulated RT transcription in vitro RL Genes Dev. 3:1982-1990 (1989). RN [2] RX MEDLINE; 89261784. RA Gallinari P., La Bella F., Heintz N. RT Characterization and Purification of H1TF2, a Novel CCAAT-Binding Protein RT That Interacts with a Histone H1 Subtype-Specific Consensus Element RL Mol. Cell. Biol. 9:1566-1575 (1989). RN [3] RX MEDLINE; 89118251. RA van Wijnen A. J., Massung R. F., Stein J. L., Stein G. S. RT Human H1 Histone Gene Promoter CCAAT Box Binding Protein HiNF-B Is a Mosaic RT Factor RL Biochemistry 27:6534-6541 (1988). RN [4] RX MEDLINE; 88124255. RA van Wijnen A. J., Wright K. L., Massung R. F., Gerretsen M., Stein J. L., RA Stein G. S. RT Two target sites for protein binding in the promoter region of a cell cycle RT regulated human H1 histone gene RL Nucleic Acids Res. 16:571-592 (1988). XX // AC G000291 XX ID HS$H1HH9 XX DT 21.05.1996 (created); ake. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H1HH9 XX DE histone 1, Hh9 gene XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.2.1.1 XX DR TRRD: 00097. XX // AC G000292 XX ID HS$H2B XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H2B XX DE histone 2B XX SY H2B/r. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.2.1.3 XX BS -59 -35 R00662; HS$H2B_01; Binding factors: POU2F1 . BS -59 -35 R00663; HS$H2B_02; Binding factors: POU2F2 (Oct-2.1) , BS POU2F2 , POU2F2B , POU2F2B . XX DR EMBL: X00088; HSHISH2B. DR TRANSPATH: G000292. XX RN [1] RX MEDLINE; 93024441. RA Kutoh E., Stroemstedt P.-E., Poellinger L. RT Functional interference between the ubiquitous and constitutive octamer RT transcription factor 1 (OTF-1) and the glucocorticoid receptor by direct RT protein-protein interaction involving the homeo subdomain of OTF-1 RL Mol. Cell. Biol. 12:4960-4969 (1992). RN [2] RX MEDLINE; 92051390. RA Chen U., Scheuermann R. H., Wirth T., Gerstler T., Roeder R. G., Harshman RA K., Berger C. RT Anti-IgM antibodies down modulate mu-enhacer activity and OTF2 levels in RT LPS-stimulated mouse splenic B-cells RL Nucleic Acids Res. 19:5981-5989 (1991). RN [3] RX MEDLINE; 90228364. RA Gerster T., Balmaceda C.-G., Roeder R. G. RT The cell type-specific octamer transcription factor OTF-2 has two domains RT required for the activation of transcription RL EMBO J. 9:1635-1643 (1990). RN [4] RX MEDLINE; 90005405. RA Kemler I., Schreiber E., Mueller M. M., Matthias P., Schaffner W. RT Octamer transcription factors bind to two different sequence motifs of the RT heavy chain promoter RL EMBO J. 8:2001-2008 (1989). RN [5] RX MEDLINE; 89160238. RA Broggini M., Ponti M., Ottolenghi S., D'Incalci M., Mongelli N., Mantovani RA R. RT Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their RT conserved DNA elements RL Nucleic Acids Res. 17:1051-1059 (1989). RN [6] RX MEDLINE; 88087220. RA O'Neill E. A., Kelly T. J. RT Purification and Characterization of Nuclear Factor III (Origin Recognition RT Protein C), a Sequence-specific DNA Binding Protein Required for Efficient RT Initiation of Adenovirus DNA Replication RL J. Biol. Chem. 263:931-937 (1988). RN [7] RX MEDLINE; 89070675. RA Scheidereit C., Cromlish J. A., Gerster T., Kawakami K., Balmaceda C.-G., RA Currie R. A., Roeder R. G. RT A human lymphoid-specific transcription factor that activates RT immunoglobulin genes is a homeobox protein RL Nature 336:551-557 (1988). RN [8] RX MEDLINE; 88052880. RA Fletcher C., Heintz N., Roeder R. G. RT Purification and Characterization of OTF-1, a Transcription Factor RT Regulating Cell Cycle Expression of a Human Histone H2b Gene RL Cell 51:773-781 (1987). RN [9] RX MEDLINE; 86313585. RA Sive H. L., Roeder R. G. RT Interaction of a common factor with conserved promoter and enhancer RT sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) RT genes RL Proc. Natl. Acad. Sci. USA 83:6382-6386 (1986). XX // AC G000293 XX ID HS$H3 XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H3 XX DE histone 3, ST519 gene XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.2.1.4 XX BS -233 -184 R00672; HS$H3_01. BS -148 -122 R00673; HS$H3_02; Binding factors: HiNF-D3 . XX DR EMBL: M26150; HSHIS3PR. DR TRANSPATH: G000293. DR TRRD: 00100. XX RN [1] RX MEDLINE; 89202043. RA Pauli U., Chrysogelos S., Nick H., Stein G., Stein J. RT In vivo binding sites and nuclease hypersensitivity in the promoter of a RT cell cycle regulated human H3 histone gene RL Nucleic Acids Res. 17:2333-2350 (1989). RN [2] RX MEDLINE; 89184528. RA Stein G., Lian J., Stein J., Briggs R., Shalhoub V., Wright K., Pauli U., RA van Wijnen A. RT Altered binding of human histone gene transcription factors during the RT shutdown of proliferation and onset of differentiation in HL-60 cells RL Proc. Natl. Acad. Sci. USA 86:1865-1869 (1989). XX // AC G000294 XX ID HS$H4F0108 XX DT 21.05.1996 (created); ake. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H4F0108 XX DE F0108 histone 4 gene XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.2.1.5 XX DR SMARTDB: SM0000172. DR TRRD: 00101. XX // AC G000295 XX ID HS$HH4 XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H4 XX DE histone 4 pHu4A gene XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1q21 XX BC 6.1.2.1.5 XX BS -152 -133 R00682; HS$HH4_03; Binding factors: HiNF-A , HiNF-E BS . BS -151 -113 R00683; HS$HH4_04; Binding factors: HiNF-A , HiNF-C BS , HiNF-E . BS -148 -133 R00686; HS$HH4_07; Binding factors: HiNF-A . BS -133 -113 R00684; HS$HH4_05; Binding factors: HiNF-C . BS -130 -40 R00685; HS$HH4_06; Binding factors: HiNF-C . BS -110 -80 R00680; HS$HH4_01; Binding factors: H4TF-1 . BS -97 -47 R00687; HS$HH4_08; Binding factors: HiNF-D , HiNF-M BS , TFIID , TMF , HiNF-P . BS -92 -64 R00688; HS$HH4_09; Binding factors: HiNF-D . BS -65 -35 R00681; HS$HH4_02; Binding factors: H4TF-2 . XX DR EMBL: M11930; HSH4A. DR EMBL: X60483; HSH4DHIS. DR EMBL: X60484; HSH4EHIS. DR EMBL: X60486; HSH4GHIS. DR EMBL: X67081; HSH4HIST. DR EMBL: X00038; HSHIH4. DR EMBL: M16707; HSHIS4. DR EMBL: M10231; HSHIS4PR. DR TRANSPATH: G000295. DR LOCUSLINK: 3022. DR OMIM: 142750. DR REFSEQ: NM_003548. XX RN [1] RX MEDLINE; 91172849. RA van Wunen A. J., Choi T. K., Owen T. A., Wright K. L., Lian J. B., Jaenisch RA R., Stein J. L., Stein G. S. RT Involvement of the cell cycle-regulated nuclear factor HiNF-D in cell RT growth control of a human H4 histone gene during hepatic development in RT transgenic mice RL Proc. Natl. Acad. Sci. USA 88:2573-2577 (1991). RN [2] RX MEDLINE; 92049307. RA La Bella F., Heintz N. RT Histone gene transcription factor binding in extracts of normal human cells RL Mol. Cell. Biol. 11:5825-5831 (1991). RN [3] RX MEDLINE; 90311356. RA Owen Th. A., Holthius J., Markose E., van Wijnen A. J., Wolfe S. A., Grimes RA S. R., Lian J. B., Stein G. S. RT Modifications of protein-DNA interactions in the proximal promoter of a RT cell-growth-regulated histone gene during onset and progression of RT osteoblast differentiation RL Proc. Natl. Acad. Sci. USA 87:5129-5133 (1990). RN [4] RX MEDLINE; 90208302. RA Holthuis J., Owen T. A., van Wijnen A. J., Wright K. L., Ramsey-Ewing A., RA Kennedy M. B., Carter R., Cosenza S. C., Soprano K. J., Lian J. B., Stein RA J. L., Stein G. S. RT Tumor cells exhibit deregulation of the cell cycle histone gene promoter RT factor HiNF-D RL Science 247:1454-1457 (1990). RN [5] RX MEDLINE; 89359315. RA van Wijnen A. J., Wright K. L., Lian J. B., Stein J. L., Stein G. S. RT Human H4 Histone Gene Transcription Requires the Proliferation-specific RT Nuclear Factor HiNF-D RL J. Biol. Chem. 264:15034-15042 (1989). RN [6] RX MEDLINE; 89184528. RA Stein G., Lian J., Stein J., Briggs R., Shalhoub V., Wright K., Pauli U., RA van Wijnen A. RT Altered binding of human histone gene transcription factors during the RT shutdown of proliferation and onset of differentiation in HL-60 cells RL Proc. Natl. Acad. Sci. USA 86:1865-1869 (1989). RN [7] RX MEDLINE; 89196888. RA Dailey L., Boseman Roberts S., Heintz N. RT Purification of the human histone H4 gene-specific transcription factors RT H4TF-1 and H4TF-2 RL Genes Dev. 2:1700-1712 (1988). RN [8] RX MEDLINE; 87146487. RA van Wijnen A. J., Stein J. L., Stein G. S. RT A nuclear protein with affinity for the 5' flanking region of a cell cycle RT dependent human H4 histone gene in vitro RL Nucleic Acids Res. 15:1679-1698 (1987). RN [9] RX MEDLINE; 87234336. RA Pauli U., Chrysogelos S., Stein G., Stein J., Nick H. RT Protein-DNA Interactions in Vivo Upstream of a Cell Cycle-Regulated Human RT H4 Histone Gene RL Science 236:1308-1311 (1987). RN [10] RX MEDLINE; 87016923. RA Dailey L., Hanly S. M., Roeder R. G., Heintz N. RT Distinct transcription factors bind specifically to two regions of the RT human histone H4 promoter RL Proc. Natl. Acad. Sci. USA 83:7241-7245 (1986). XX // AC G000296 XX ID HS$HOX4C XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HOX4C XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 2q31-q37 XX BS -703 -696 R04091; HS$HOX4C_01; Binding factors: HOXD9 , HOXD10 BS , HOXD8 , HOXD8 , HOXD9 , HOXD9 , BS HOXD10 , HOXD10 . BS -692 -678 R04092; HS$HOX4C_02; Binding factors: HOXD9 , HOXD10 BS , HOXD9 , HOXD9 , HOXD10 , HOXD10 . BS -688 -674 R04093; HS$HOX4C_03; Binding factors: HOXD8 , HOXD8 BS . BS -669 -649 R04094; HS$HOX4C_04; Binding factors: HOXD9 , HOXD10 BS , HOXD9 , HOXD9 , HOXD10 , HOXD10 . BS -645 -630 R04095; HS$HOX4C_05; Binding factors: HOXD9 , HOXD10 BS , HOXD9 , HOXD9 , HOXD10 , HOXD10 . BS -643 -630 R04096; HS$HOX4C_06; Binding factors: HOXD8 , HOXD8 BS . XX DR TRANSPATH: G000296. DR LOCUSLINK: 3235. DR OMIM: 142982. DR REFSEQ: NM_014213. XX RN [1] RX MEDLINE; 92097538. RA Zappavigna V., Renucci A., Izpisua-Belmonte J.-C., Urier G., Peschle C., RA Duboule D. RT HOX4 genes encode transcription factors with potential auto- and RT cross-regulatory capacities RL EMBO J. 10:4177-4187 (1991). XX // AC G000297 XX ID HS$HPX XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Hpx XX DE hemopexin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.5-p15.4 XX BC 6.1.3.13 XX BS -120 -104 R03152; HS$HPX_01; Binding factors: C/EBPalpha , BS C/EBPdelta , C/EBPbeta . XX DR EMBL: X15399; HSHEMPRO. DR EMBL: M36796; HSHXMA1. DR TRANSPATH: G000297. DR TRRD: 00189. DR LOCUSLINK: 3263. DR OMIM: 142290. DR REFSEQ: NM_000613. XX RN [1] RX MEDLINE; 93181204. RA Ramji D. P., Vitelli A., Tronche F., Cortese R., Ciliberto G. RT The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are RT induced by IL-6 to promote acute phase gene transcription via different RT mechanisms RL Nucleic Acids Res. 21:289-294 (1993). RN [2] RX MEDLINE; 91029495. RA Poli V., Mancini F. P., Cortese R. RT IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, RT defines a new family of leucine zipper proteins related to C/EBP RL Cell 63:643-653 (1990). XX // AC G000298 XX ID HS$HSP90B XX DT 21.05.1996 (created); ake. DT 14.09.2001 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD hsp90beta XX DE 90-kDa heat shock protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6 XX BC 6.1.6.2 XX DR TRANSCOMPEL: C00296. DR TRRD: 00180. DR LOCUSLINK: 3326. DR OMIM: 140572. DR REFSEQ: NM_007355. XX // AC G000304 XX ID HS$HPRT XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HPRT XX DE hypoxanthine-guanine phosphribosyltransferase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH Xq26.1 XX BC 6.1.4.2 XX DR SMARTDB: SM0000083. DR SMARTDB: SM0000119. DR BRENDA: 2.4.2.8; Human. DR TRRD: 00031. DR LOCUSLINK: 3251. DR OMIM: 308000. DR REFSEQ: NM_000194. XX // AC G000305 XX ID HS$IFI XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IFI-56K XX DE interferon-inducible gene IFI-56K XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.7.2 XX BS -213 -199 R00827; HS$IFI_01. BS -193 -177 R00828; HS$IFI_02. BS -125 -93 R02402; HS$IFI_03; Binding factors: ISGF-3 . XX DR EMBL: X06559; HSIFI56. DR TRANSPATH: G000305. DR TRRD: 00272. XX RN [1] RX MEDLINE; 91187669. RA Roy Ch., Lebleu B. RT DNA protein interactions at the interferon-responsive promoter elements: RT potential for a H-DNA conformation RL Nucleic Acids Res. 19:517 (1991). RN [2] RX MEDLINE; 90377194. RA Bandyopadhyay S. K., Kalvakolanu Dh. V. R., Sen G. C. RT Gene induction by interferons: functional complementation between RT trans-acting factors induced by alpha interferon and gamma interferon RL Mol. Cell. Biol. 10:5055-5063 (1990). RN [3] RX MEDLINE; 90245659. RA Roy C., Lebleu B. RT DNA-protein interactions at the interferon-responsive promoter: evidences RT for an involvement of phosphorylation RL Nucleic Acids Res. 18:2125-2131 (1990). XX // AC G000306 XX ID HS$IFNAJ XX DT 14.06.1995 (created); dbo. DT 19.02.1999 (updated); ili. CO Copyright (C), Biobase GmbH. XX SD IFN-alpha XX DE leukocyte interferon gene J XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.5.8 XX BS 1 0 R03177; HS$IFNAJ_01; Binding factors: YY1 . XX DR EMBL: V00531; HSIFD1. DR TRANSPATH: G000306. DR SMARTDB: SM0000011. DR SMARTDB: SM0000012. XX RN [1] RX MEDLINE; 92072698. RA Seto E., Shi Y., Shenk T. RT YY1 is an initiator sequence-binding protein that directs and activates RT transcription in vitro RL Nature 354:241-245 (1991). XX // AC G000307 XX ID HS$IFNA1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IFN-alpha1 XX DE interferon-alpha1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 9p22 XX BC 6.1.5.8 XX BS -174 -38 R01743; HS$IFNA1_02. BS -110 -51 R12442; HS$IFNA1_04; Binding factors: IRF3 , IRF-5 BS , IRF-7H . BS -103 -67 R12440; HS$IFNA1_03; Binding factors: IRF3 , IRF-7H BS . BS -84 -74 R00915; HS$IFNA1_01; Binding factors: IRF1 , IRF1 BS , IRF-2 . XX DR EMBL: J00210; HSIFNAD. DR TRANSPATH: G000307. DR TRRD: 00273. DR LOCUSLINK: 3439. DR OMIM: 147660. DR REFSEQ: NM_024013. XX RN [1] RX MEDLINE; 21316468. RA Barnes B. J., Moore P. A., Pitha P. M. RT Virus-specific activation of a novel interferon regulatory factor, IRF-5, RT results in the induction of distinct interferon alpha genes. RL J. Biol. Chem. 276:23382-23390 (2001). RN [2] RX MEDLINE; 20158941. RA Yeow W. S., Au W. C., Juang Y. T., Fields C. D., Dent C. L., Gewert D. R., RA Pitha P. M. RT Reconstitution of virus-mediated expression of interferon alpha genes in RT human fibroblast cells by ectopic interferon regulatory factor-7. RL J. Biol. Chem. 275:6313-6320 (2000). RN [3] RX MEDLINE; 90258840. RA Palmieri M., Tovey M. G. RT Genomic footprinting: Detection of putative regulatory proteins in the RT promoter region of the interferon alpha_1 gene in normal human tissues RL Mol. Cell. Biol. 10:2554-2561 (1990). RN [4] RX MEDLINE; 89354547. RA Harada H., Fujita T., Miyamoto M., Kimura Y., Maruyama M., Furia A., Miyata RA T., Taniguchi T. RT Structurally similar but functionally distinct factors, IRF-1 and IRF-2, RT bind to the same regulatory elements of IFN and IFN-inducible genes RL Cell 58:729-739 (1989). XX // AC G000308 XX ID HS$IFNB XX DT 14.06.1995 (created); dbo. DT 02.12.1998 (updated); ili. CO Copyright (C), Biobase GmbH. XX SD IFN-beta XX DE interferon-beta 1 XX SY IFNB; IFB. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 9p22 XX BC 6.1.5.8 XX BS -202 -135 R00929; HS$IFNB_14. BS -167 -94 R00916; HS$IFNB_01; Binding factors: R2 . BS -100 -61 R00917; HS$IFNB_02; Binding factors: IRF1 , IRF-2 BS . BS -94 -78 R00918; HS$IFNB_03. BS -82 -60 R00919; HS$IFNB_04; Binding factors: IBP-1 , ICSBP BS , IRF1 , IRF-2 . BS -79 -64 R00924; HS$IFNB_09. BS -77 -64 R00925; HS$IFNB_10; Binding factors: ITF . BS -74 -63 R00926; HS$IFNB_11; Binding factors: PRDI-BFc . BS -74 -63 R00927; HS$IFNB_12; Binding factors: ICSBP , IRF1 BS , PRDI-BF1 . BS -69 -49 R00920; HS$IFNB_05; Binding factors: NF-kappaB1 . BS -69 -54 R00928; HS$IFNB_13; Binding factors: MBP-1 (1) . BS -68 -38 R00921; HS$IFNB_06; Binding factors: R1 . BS -66 -57 R00922; HS$IFNB_07; Binding factors: NF-kappaB2 , BS NF-kappaB2 precursor . BS -66 -55 R00923; HS$IFNB_08; Binding factors: NF-kappaB , BS NF-kappaB1 , RelA . XX DR EMBL: V00534; HSIFD4. DR EMBL: X60459; HSIFNAR. DR EMBL: X00973; HSIFR20. DR TRANSPATH: G000308. DR TRANSCOMPEL: C00057. DR TRANSCOMPEL: C00061. DR TRANSCOMPEL: C00092. DR TRANSCOMPEL: C00094. DR TRANSCOMPEL: C00099. DR TRANSCOMPEL: C00333. DR SMARTDB: SM0000002. DR SMARTDB: SM0000005. DR SMARTDB: SM0000006. DR SMARTDB: SM0000008. DR SMARTDB: SM0000009. DR SMARTDB: SM0000010. DR TRRD: 00274. DR LOCUSLINK: 3456. DR OMIM: 147640. DR REFSEQ: NM_002176. XX RN [1] RX MEDLINE; 92236567. RA Keller A. D., Maniatis T. RT Only two of the five zinc fingers of the eukaryotic transcriptional RT repressor PRDI-BF1 are required for sequence-specific DNA binding RL Mol. Cell. Biol. 12:1940-1949 (1992). RN [2] RX MEDLINE; 91266911. RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [3] RX MEDLINE; 91224495. RA Keller A. D., Maniatis T. RT Identification and characterization of a novel repressor of beta-interferon RT gene expression RL Genes Dev. 5:868-879 (1991). RN [4] RX MEDLINE; 92065981. RA Fan C.-M., Maniatis T. RT Generation of p50 subunit of NF-kappaB by processing of p105 through an RT ATP-dependent pathway RL Nature 354:395-398 (1991). RN [5] RX MEDLINE; 91360341. RA Watanabe N., Sakakibara J., Hovanessian A. G., Taniguchi T., Fujita T. RT Activation of IFN-beta element by IRF-1 requires a post-translational event RT in addition to IRF-1 synthesis RL Nucleic Acids Res. 19:4421-4428 (1991). RN [6] RX MEDLINE; 90211285. RA Xanthoudakis S., Hiscott J. RT UV cross-linking of distinct proteins to the PRDII domain of the RT interferon-beta promoter RL Biochem. Biophys. Res. Commun. 167:1086-1093 (1990). RN [7] RX MEDLINE; 90169514. RA Fan C.-M., Maniatis T. RT A DNA-binding protein containing two widely separated zinc finger motifs RT that recognize the same DNA sequence RL Genes Dev. 4:29-42 (1990). RN [8] RX MEDLINE; 90258828. RA Pine R., Decker T., Kessler D. S., Levy D. E., Darnell J. E. RT Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): RT ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and RT Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator RT of Either RL Mol. Cell. Biol. 10:2448-2457 (1990). RN [9] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [10] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [11] RX MEDLINE; 89195239. RA Lenardo M. J., Fan C.-M., Maniatis T., Baltimore D. RT The Involvement of NF-kB in beta-Interferon Gene Regulation Reveals Its RT Role as Widely Inducible Mediator of Signal Transduction RL Cell 57:287-294 (1989). RN [12] RX MEDLINE; 89354547. RA Harada H., Fujita T., Miyamoto M., Kimura Y., Maruyama M., Furia A., Miyata RA T., Taniguchi T. RT Structurally similar but functionally distinct factors, IRF-1 and IRF-2, RT bind to the same regulatory elements of IFN and IFN-inducible genes RL Cell 58:729-739 (1989). RN [13] RX MEDLINE; 89195239. RA Lenardo M. J., Fan C.-M., Maniatis T., Baltimore D. RT The involvement of NF-kappaB in beta-interferon gene regulation reveals its RT role as a widely inducible mediator of signal transduction RL Cell 57:287-294 (1989). RN [14] RX MEDLINE; 89305515. RA Blanar M. A., Baldwin jr A. S., Flavell R. A., Sharp P. A. RT A gamma-interferon-induced factor that binds the interferon response RT sequence of the MHC class I gene, H-2Kb RL EMBO J. 8:1139-1144 (1989). RN [15] RX MEDLINE; 89305514. RA Visvanathan K. V., Goodbourn S. RT Double-stranded RNA activates binding of NF-kB to an inducible element in RT the human beta-interferon promoter RL EMBO J. 8:1129-1138 (1989). RN [16] RX MEDLINE; 89305514. RA Visvanathan K. V., Goodbourn S. RT Double-stranded RNA activates binding of NF-kappaB to an inducible element RT in the human beta-interferon promoter RL EMBO J. 8:1129-1138 (1989). RN [17] RX MEDLINE; 89093100. RA Xanthoudakis S., Cohen L., Hiscott J. RT Multiple Protein-DNA Interactions within the Human Interferon-beta RT Regulatory Element RL J. Biol. Chem. 264:1139-1145 (1989). RN [18] RX MEDLINE; 89128426. RA Clark L., Hay R. T. RT Sequence requirements for specific interaction of an enhancer binding RT protein (EBP1) with DNA RL Nucleic Acids Res. 17:499-516 (1989). RN [19] RX MEDLINE; 89263776. RA Fujita T., Miyamoto M., Kimura Y., Hammer J., Taniguchi T. RT Involvement of a cis-element that binds an H2TF-1/NFkappaB like factor(s) RT in the virus-induced interferon-beta gene expression RL Nucleic Acids Res. 17:3335-3346 (1989). RN [20] RX MEDLINE; 88311092. RA Miyamoto M., Fujita T., Kimura Y., Maruyama M., Harada H., Sudo Y., Miyata RA T., Taniguchi T. RT Regulated Expression of a Gene Encoding a Nuclear Factor, IRF-1, That RT Specifically Binds to IFN-beta Gene Regulatory Elements RL Cell 54:903-913 (1988). RN [21] RX MEDLINE; 89091081. RA Fujita T., Sakakibara J., Sudo Y., Miyamoto M., Kimura Y., Taniguchi T. RT Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing RT properties to human IFN-beta gene regulatory elements RL EMBO J. 11:3397-3405 (1988). RN [22] RX MEDLINE; 88217890. RA Keller A. D., Maniatis T. RT Identification of an inducible factor that binds to a positive regulatory RT element of the human beta-interferon gene RL Proc. Natl. Acad. Sci. USA 85:3309-3313 (1988). RN [23] RX MEDLINE; 87250428. RA Xanthoudakis S., Hiscott J. RT Identification of a Nuclear DNA Binding Protein Associated with the RT Interferon-beta Upstream Regulatory Region RL J. Biol. Chem. 262:8298-8302 (1987). RN [24] RX MEDLINE; 86218074. RA Zinn K., Maniatis T. RT Detection of factors that interact with the human beta-interferon RT regulatory region in vivo by DNAase I footprinting RL Cell 45:611-618 (1986). XX // AC G000309 XX ID HS$IGF2 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IGF-II XX DE insulin-like growth factor II XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.5 XX BC 6.1.5.5 XX BS -238 -210 R02313; HS$IGF2_01; Binding factors: WT1 . BS -133 -119 R02314; HS$IGF2_02; Binding factors: WT1 . BS 48 70 R02315; HS$IGF2_03; Binding factors: WT1 . XX DR EMBL: X03562; HSIGF2G. DR TRANSPATH: G000309. DR TRRD: 00154. DR LOCUSLINK: 3481. DR OMIM: 147470. DR REFSEQ: NM_000612. XX RN [1] RX MEDLINE; 92358215. RA Drummond I. A., Madden St. L., Rohwer-Nutter P., Bell G. I., Sukhatme V. RA P., Rauscher III F. J. RT Repression of the Insulin-like Growth Factor II gene by the Wilms tumor RT suppressor WT1 RL Science 257:674-678 (1992). XX // AC G000310 XX ID HS$IGFBP1 XX DT 14.06.1995 (created); dbo. DT 08.04.2002 (updated); mas. CO Copyright (C), Biobase GmbH. XX SD IGFBP-1 XX DE insulin-like growth factor binding protein-1 XX SY IBP1; IGF; PP12. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 7p13-p12 XX BC 6.1.3 XX BS -273 -249 R12331; HS$IGFBP1_06; Binding factors: CREB . BS -198 -173 R12328; HS$IGFBP1_03; Binding factors: GR alpha . BS -124 -96 R04663; HS$IGFBP1_02; Binding factors: HNF-3alpha , BS HNF-3B , HMG I , HMG Y , HNF-3beta , BS HNF-3alpha , HNF-3beta , FOXO3a . BS -124 -96 R12332; HS$IGFBP1_07. BS -110 -84 R12329; HS$IGFBP1_04; Binding factors: GR alpha . BS -79 -53 R02910; HS$IGFBP1_01; Binding factors: HNF-1A , HNF-1B BS , HNF-1C . BS -52 -25 R12330; HS$IGFBP1_05; Binding factors: GR alpha . XX FA T00400; IBP-1. XX DR EMBL: M59316; HSIGFBP1. DR TRANSPATH: G000310. DR TRANSCOMPEL: C00130. DR TRRD: 00073. DR LOCUSLINK: 3484. DR OMIM: 146730. DR REFSEQ: NM_000596. XX RN [1] RX MEDLINE; 93352482. RA Suwanickul A., Morris S. L., Powell D. R. RT Identification of an insulin-responsive element in the promoter of the RT human gene for insulin-like growth factor binding protein-1 RL J. Biol. Chem. 268:17063-17068 (1993). RN [2] RX MEDLINE; 99200396. RA Brunet A., Bonni A., Zigmond M. J., Lin M. Z., Juo P., Hu L. S., Anderson RA M. J., Arden K. C., Blenis J., Greenberg M. E. RT Akt promotes cell survival by phosphorylating and inhibiting a forkhead RT transcription factor RL Cell 96:857-868 (1999). RN [3] RX MEDLINE; 97462715. RA Allander S. V., Durham S. K., Scheimann A. O., Wasserman R. M., Suwnichkul RA A., Powell D. R. RT Hepatic Nuclear Factor 3 and High Mobility Group I/Y proteins bind the RT Insulin Response Element of the Insulin-like Growth Factor-Binding RT Protein-1 promoter RL Endocrinology 138:4291-4300 (1997). RN [4] RX MEDLINE; 95166260. RA O'Brien R. M., Noisin E. L., Suwanichkul A., Yamasaki T., Lucas P. C., Wang RA J.-C., Powell D. R., Granner D. K. RT Hepatic nuclear factor 3- and hormone-regulated expression of the RT phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding RT protein 1 genes RL Mol. Cell. Biol. 15:1747-1758 (1995). RN [5] RX MEDLINE; 95074111. RA Suwanichkul A., Allander S. V., Morris S. L., Powell D. R. RT Glucocorticoids and insulin regulate expression of the human gene for RT insulin-like growth factor-binding protein-1 through proximal promoter RT elements RL J. Biol. Chem. 269:30835-30841 (1994). RN [6] RX MEDLINE; 93252850. RA Suwanichkul A., DePaolis L. A., Lee P. D., Powell D. R. RT Identification of a promoter element which participates in cAMP-stimulated RT expression of human insulin-like growth factor-binding protein-1 RL J. Biol. Chem. 268:9730-9736 (1993). RN [7] RX MEDLINE; 91065933. RA Suwanichkul A., Cubbage M. L., Powell D. R. RT The protein of the human gene for insulin-like growth factor binding RT protein-1 RL J. Biol. Chem. 265:21185-21193 (1990). XX // AC G000311 XX ID HS$IL1B XX DT 14.06.1995 (created); dbo. DT 21.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD IL-1beta XX DE interleukin 1, beta XX SY IL-1; IL-1beta; prointerleukin-1beta. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 2q13-q21 XX BC 6.1.5.9 XX BS -2782 -2729 R08084; HS$IL1B_02; Binding factors: CREB , BS C/EBPbeta . BS -49 -38 R04274; HS$IL1B_01. XX DR EMBL: X04500; HSIL1B. DR TRANSPATH: G000311. DR TRANSCOMPEL: C00259. DR TRRD: 00263. DR LOCUSLINK: 3553. DR OMIM: 147720. DR REFSEQ: NM_000576. XX RN [1] RX MEDLINE; 95021257. RA Tsukada J., Saito K., Waterman W. R., Webb A. C., Auron P. E. RT Transcription factors NF-IL6 and CREB recognize a common essential site in RT the human prointerleukin 1beta gene RL Mol. Cell. Biol. 14:7285-7297 (1994). RN [2] RX MEDLINE; 92334343. RA Hunninghake G. W., Monks B. G., Geist L. J., Monick M. M., Monroy M. A., RA Stinski M. F., Webb A. C., Dayer J.-M., Auron P. E., Fenton M. J. RT The functional importance of a cap site-proximal region of the human RT prointerleukin 1beta gene is defined by viral protein trans-activation RL Mol. Cell. Biol. 12:3439-3448 (1992). XX // AC G000312 XX ID HS$IL2 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IL-2 XX DE interleukin-2 XX SY TCGF. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q26-q27 XX BC 6.1.5.9 XX BS -291 -263 R00930; HS$IL2_01; Binding factors: NFAT-1 , FOXK1a BS , ELF-1 , p28 modulator . BS -285 -258 R00931; HS$IL2_02; Binding factors: NFAT-1 . BS -285 -258 R05035; HS$IL2_15; Binding factors: c-Fos , c-Jun BS , Fra-1 , JunB . BS -285 -254 R09813; HS$IL2_16; Binding factors: FOXN2 . BS -256 -242 R00932; HS$IL2_03; Binding factors: NF-IL-2A , POU2F1 BS , POU2F2 (Oct-2.1) . BS -207 -191 R00933; HS$IL2_04; Binding factors: NF III-a , BS NF-kappaB , NF-kappaB1 . BS -192 -162 R00934; HS$IL2_05; Binding factors: AP-1 . BS -164 -140 R03673; HS$IL2_13; Binding factors: CD28RC , NF-IL-2B BS . BS -162 -152 R00935; HS$IL2_06; Binding factors: CD28RC , NF III-c BS , NF-kappaB , TxREF . BS -160 0 R04298; HS$IL2_14; Binding factors: ELF-1 . BS -157 -140 R03522; HS$IL2_12; Binding factors: AP-1 , c-Fos BS , c-Jun . BS -112 -99 R02304; HS$IL2_11; Binding factors: AREB6 . BS -93 -65 R00936; HS$IL2_07; Binding factors: NF-IL-2A , POU2F1 BS , POU2F2 (Oct-2.1) . BS -86 -66 R00937; HS$IL2_08; Binding factors: NF III-e . BS -31 -19 R00938; HS$IL2_09. BS -1 16 R00939; HS$IL2_10. XX DR EMBL: X00695; HSIL05. DR TRANSPATH: G000312. DR TRANSCOMPEL: C00109. DR TRANSCOMPEL: C00165. DR TRANSCOMPEL: C00166. DR TRANSCOMPEL: C00168. DR TRANSCOMPEL: C00345. DR TRRD: 00074. DR LOCUSLINK: 3558. DR OMIM: 147680. DR REFSEQ: NM_000586. XX RN [1] RX MEDLINE; 95021217. RA Yaseen N. R., Park J., Kerppola T., Curran T., Sharma S. RT A central role for Fos in human B- and T-cell NFAT (nuclear factor of RT activated T cells): an acidic region is required for in vitro assembly RL Mol. Cell. Biol. 14:6886-6895 (1994). RN [2] RX MEDLINE; 93232271. RA Paliogianni F., Raptis A., Ahuja S. S., Najjar S. M., Boumpas D. T. RT Negative transcriptional regulation of human interleukin 2 (IL-2) gene by RT glucocorticoids through interference with nuclear transcription factors RT AP-1 and NF-AT RL J. Clin. Invest. 91:1481-1489 (1993). RN [3] RX MEDLINE; 93180840. RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., Lindsten T., Bravo RA R., Kovary K., Leiden J., Thompson C. B. RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB RL Mol. Cell. Biol. 13:1911-1919 (1993). RN [4] RX MEDLINE; 94019323. RA Li M., Siekevitz M. RT A cis element required for induction of the interleukin 2 enhancer by human RT T-cell leukemia virus type I binds a novel Tax-inducible nuclear protein. RL Mol. Cell. Biol. 13:6490-6500 (1993). RN [5] RX MEDLINE; 93024377. RA Fraser J. D., Weiss A. RT Regulation of T-cell lymphokine gene transcription by the accessory RT molecule CD28 RL Mol. Cell. Biol. 12:4357-4363 (1992). RN [6] RX MEDLINE; 92186836. RA Thompson C. B., Wang C.-Y., Ho I-C., Bohjanen P. R., Petryniak B., June C. RA H., Miesfeldt S., Zhang L., Nabel G. J., Karpinski B., Leiden J. M. RT cis-acting sequences required for inducible interleukin-2 enhancer function RT bind a novel Ets-related protein, Elf-1 RL Mol. Cell. Biol. 12:1043-1053 (1992). RN [7] RX MEDLINE; 92347862. RA Li C., Lusis A. J., Sparkes R., Tran S. M., Gaynor R. RT Characterization and chromosomal mapping of the gene encoding the cellular RT DNA binding protein HTLF RL Genomics 13:658-664 (1992). RN [8] RX MEDLINE; 91317760. RA Verweji C. L., Geerts M., Aarden L. A. RT Activation of interleukin-2 gene transcription via the T-cell surface RT molecule CD28 is mediated through an NF-kB-like response element RL J. Biol. Chem. 266:14179-14182 (1991). RN [9] RX MEDLINE; 91304399. RA Banerji S. S., Parsons J. N., Tocci M. J. RT The immunosuppressant FK-506 specifically inhibits mitogen-induced RT activation of the interleukin-2 promoter and the isolated enhancer elements RT NFIL-2A and NF-AT1 RL Mol. Cell. Biol. 11:4074-4087 (1991). RN [10] RX MEDLINE; 91342681. RA Felli M. P., Vacca A., Meco D., Screpanti I., Farina A. R., Maroder M., RA Martinotti S., Petrangeli E., Frati L., Gulino A. RT Retinoic acid-induced down-regulation of the interleukin-2 promoter via RT cis-regulatory sequences containing an octamer motif RL Mol. Cell. Biol. 11:4771-4778 (1991). RN [11] RX MEDLINE; 91346138. RA Baumann G., Geisse S., Sullivan M. RT Cyclosporin A and FK-506 both affect DNA binding of regulatory nuclear RT proteins to the human interleukin-2 promoter RL New Biol. 3:270-278 (1991). RN [12] RX MEDLINE; 91352065. RA Li C., Lai C., Sigman D. S., Gaynor R. B. RT Cloning of a cellular factor, interleukin binding factor, that binds to RT NFAT-like motifs in the human immunodeficiency virus long terminal repeat RL Proc. Natl. Acad. Sci. USA 88:7739-7743 (1991). RN [13] RX MEDLINE; 92107964. RA Granelli-Piperno A., McHugh P. RT Characterization of a protein that regulates the DNA-binding activity of RT NF-AT, the nuclear factor of activated T cells RL Proc. Natl. Acad. Sci. USA 88:11431-11434 (1991). RN [14] RX MEDLINE; 91102586. RA Fraser J. D., Irving B. A., Crabtree G. R., Weiss A. RT Regulation of interleukin-2 gene enhancer activity by the T-cell accessory RT molecule CD28 RL Science 251:313-316 (1991). RN [15] RX MEDLINE; 92108424. RA Williams T. M., Moolten D., Burlein J., Romano J., Bhaerman R., Godillot RA A., Mellon M., Rauscher III F. J., Kant J. A. RT Identification of a zinc finger protein that inhibits IL-2 gene expression RL Science 254:1791-1794 (1991). RN [16] RX MEDLINE; 91065527. RA Fiering S., Northrop J. P., Nolan G. P., Mattila P. S., Crabtree G. R., RA Herzenberg L. A. RT Single cell assay of a transcription factor reveals a threshold in RT transcription activated by signals emanating from the T-cell antigen RT receptor RL Genes Dev. 4:1823-1834 (1990). RN [17] RX MEDLINE; 90368794. RA Verweij C. L., Guidos C., Crabtree G. R. RT Cell type specificity and activation requirements for NFAT-1 (Nuclear RT Factor of Activated T-cells) transcriptional activity determined by a new RT method using transgenic mice to assay transcriptional activity of an RT individual nuclear factor RL J. Biol. Chem. 265:15788-15795 (1990). RN [18] RX MEDLINE; 90377237. RA Kamps M. P., Corcoran L., LeBowitz J. H., Baltimore D. RT The promoter of the human interleukin-2 gene contains two octamer-binding RT sites and is partially activated by the expression of Oct-2 RL Mol. Cell. Biol. 10:5464-5472 (1990). RN [19] RX MEDLINE; 91043047. RA Bours V., Villalobos J., Burd P. R., Kelly K., Siebenlist U. RT Cloning of a mitogen-inducible gene encoding a kappaB DNA-binding protein RT with homology to the rel oncogene and to cell-cycle motifs RL Nature 348:76-80 (1990). RN [20] RX MEDLINE; 90067918. RA Shibuya H., Taniguchi T. RT Identification of multiple cis-elements and trans-acting factors involved RT in the induced expression of human IL-2 gene RL Nucleic Acids Res. 17:9173-9184 (1989). RN [21] RX MEDLINE; 89242103. RA Hoyos B., Ballard D. W., Boehnlein E., Siekevitz M., Greene W. C. RT Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human RT Interleukin-2 Gene Expression RL Science 244:457-460 (1989). RN [22] RX MEDLINE; 90019528. RA Muegge K., Williams T. M., Kant J., Karin M., Chiu R., Schmidt A., RA Siebenlist U., Young H. A., Durum S. K. RT Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1 RL Science 246:249-251 (1989). RN [23] RX MEDLINE; 89066685. RA Brunvand M. W., Schmidt A., Siebenlist U. RT Nuclear Factors Interacting with the Mitogen-responsive Regulatory Region RT of the Interleukin-2 Gene RL J. Biol. Chem. 263:18904-18910 (1988). RN [24] RX MEDLINE; 88246442. RA Durand D. B., Shaw J.-P., Bush M. R., Replogle R. E., Belagaje R., Crabtree RA G. R. RT Characterization of Antigen Receptor Response Elements within the RT Interleukin-2 Enhancer RL Mol. Cell. Biol. 8:1715-1724 (1988). RN [25] RX MEDLINE; 88203615. RA Nabel G. J., Gorka C., Baltimore D. RT T-cell-specific expression of interleukin 2: Evidence for a negative RT regulatory site RL Proc. Natl. Acad. Sci. USA 85:2934-2938 (1988). RN [26] RX MEDLINE; 88264423. RA Shaw J.-P., Utz P. J., Durand D. B., Toole J. J., Emmel E. A., Crabtree G. RA R. RT Identification of a Putative Regulator of Early T Cell Activation Genes RL Science 241:202-205 (1988). XX // AC G000313 XX ID HS$IL2RA XX DT 14.06.1995 (created); dbo. DT 18.09.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD IL-2Ralpha XX DE interleukin-2 receptor, alpha chain XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 10p15-p14 XX BC 6.1.5.15 XX BS -3775 -3754 R11154; HS$IL2RA_06; Binding factors: STAT6 , STAT5A BS , STAT1 , STAT5B . BS -3755 -3735 R11155; HS$IL2RA_07; Binding factors: STAT6 , STAT5A BS , STAT1 , STAT5B . BS -291 -245 R00940; HS$IL2RA_01; Binding factors: c-Rel , BS NF-kappaB . BS -267 -256 R00941; HS$IL2RA_02; Binding factors: c-Rel . BS -267 -243 R00942; HS$IL2RA_03; Binding factors: NF-kappaB . BS -266 -252 R00943; HS$IL2RA_04; Binding factors: c-Rel , BS NF-kappaB , NF-kappaB1 , RelA . BS -266 -252 R00944; HS$IL2RA_05; Binding factors: 50-55K protein BS , 70-75K protein , 80-90K protein . XX DR EMBL: Z70243; HSENHREG1. DR EMBL: M15864; HSIL2R1A. DR TRANSPATH: G000313. DR TRANSCOMPEL: C00118. DR TRANSCOMPEL: C00313. DR TRANSCOMPEL: C00314. DR TRANSCOMPEL: C00315. DR TRRD: 00173. DR LOCUSLINK: 3559. DR OMIM: 147730. DR REFSEQ: NM_000417. XX RN [1] RX MEDLINE; 21125882. RA Ehret G. B., Reichenbach P., Schindler U., Horvath C. M., Fritz S., Nabholz RA M., Bucher P. RT DNA binding specificity of different STAT proteins. Comparison of in vitro RT specificity with natural target sites. RL J. Biol. Chem. 276:6675-6688 (2001). RN [2] RX MEDLINE; 98058981. RA Meyer W. K., Reichenbach P., Schindler U., Soldaini E., Nabholz M. RT Interaction of STAT5 dimers on two low affinity binding sites mediates RT interleukin 2 (IL-2) stimulation of IL-2 receptor alpha gene transcription. RL J. Biol. Chem. 272:31821-31828 (1997). RN [3] RX MEDLINE; 97220026. RA Lecine P., Algarte M., Rameil P., Beadling C., Bucher P., Nabholz M., RA Imbert J. RT Elf-1 and Stat5 bind to a critical element in a new enhancer of the human RT interleukin-2 receptor alpha gene. RL Mol. Cell. Biol. 17:2351 (1997). RN [4] RX MEDLINE; 97098661. RA Lecine P., Algarte M., Rameil P., Beadling C., Bucher P., Nabholz M., RA Imbert J. RT Elf-1 and Stat5 bind to a critical element in a new enhancer of the human RT interleukin-2 receptor alpha gene. RL Mol. Cell. Biol. 16:6829-6840 (1996). RN [5] RX MEDLINE; 92375075. RA Tan T.-H., Huang G. P., Sica A., Ghosh P., Young H. A., Longo D. L., Rice RA N. R. RT KappaB site-dependent activation of the interleukin-2 receptor alpha-chain RT gene promoter by human c-Rel RL Mol. Cell. Biol. 12:4067-4075 (1992). RN [6] RX MEDLINE; 92046353. RA Arima N., Molitor J. A., Smith M. R., Kim J. H., Daitoku Y., Greene W. C. RT Human T-cell leukemia virus type I Tax induces expression of the RT Rel-related family of kappaB enhancer-binding proteins: evidence for a RT pretranslational component of regulation RL J. Virol. 65:6892-6899 (1991). RN [7] RX MEDLINE; 91029511. RA Ballard D. W., Walker W. H., Doerre S., Sista P., Molitor J. A., Dixon E. RA P., Peffer N. J., Hannink M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding protein that inhibits RT NF-kappaB function RL Cell 63:803-814 (1990). RN [8] RX MEDLINE; 91088538. RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially expressed RT enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [9] RX MEDLINE; 89255295. RA Boehnlein E., Ballard D. W., Bogerd H., Peffer N. J., Lowenthal J. W., RA Greene W. C. RT Induction of Interleukin-2 Receptor-alpha Gene Expression Is Regulated by RT Post-transcriptional Activation of kB Specific DNA Binding Proteins RL J. Biol. Chem. 264:8475-8478 (1989). RN [10] RX MEDLINE; 89184620. RA Lowenthal J. W., Ballard D. W., Boehnlein E., Greene W. C. RT Tumor necrosis factor alpha induces proteins that bind specifically to RT kB-like enhancer elements and regulate interleukin 2 receptor alpha-chain RT gene expression in primary human T lymphocytes RL Proc. Natl. Acad. Sci. USA 86:2331-2335 (1989). RN [11] RX MEDLINE; 89242103. RA Hoyos B., Ballard D. W., Boehnlein E., Siekevitz M., Greene W. C. RT Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human RT Interleukin-2 Gene Expression RL Science 244:457-460 (1989). RN [12] RX MEDLINE; 89242106. RA Cross S. L., Halden N. F., Lenardo M. J., Leonard W. J. RT Functionally Distinct NF-kB Binding Sites in the Immunoglobulin k and IL-2 RT Receptor alpha Chain Genes RL Science 244:466-469 (1989). RN [13] RX MEDLINE; 88223375. RA Boehnlein E., Lowenthal J. W., Siekevitz M., Ballard D. W., Franza B. R., RA Greene W. C. RT The Same Inducible Nuclear Protein Regulates Mitogen Activation of Both the RT Interleukin-2 Receptor-Alpha Gene and Type 1 HIV RL Cell 53:827-836 (1988). RN [14] RX MEDLINE; 88261502. RA Leung K., Nabel G. J. RT HTLV-1 transactivator induces interleukin-2 receptor expression through an RT NF-kB-like factor RL Nature 333:776-778 (1988). RN [15] RX MEDLINE; 88248039. RA Lowenthal J. W., Boehnlein E., Ballard D. W., Greene W. C. RT Regulation of interleukin 2 receptor alpha subunit (Tac of CD25 antigen) RT gene expression: Binding of inducible nuclear proteins to discrete promoter RT sequences correlates with transcriptional activation RL Proc. Natl. Acad. Sci. USA 85:4468-4472 (1988). RN [16] RX MEDLINE; 88336901. RA Ballard D. W., Boehnlein E., Lowenthal J. W., Wano Y., Franza B. R., Greene RA W. C. RT HTLV-I Tax Induces Cellular Proteins That Activate the kB Element in the RT IL-2 Receptor alpha Gene RL Science 241:1652-1655 (1988). RN [17] RX MEDLINE; 88264409. RA Ruben S., Poteat H., Tan T.-H., Kawakami K., Roeder R., Haseltine W., Rosen RA C. A. RT Cellular Transcription Factors and Regulation of IL-2 Receptor Gene RT Expression by HTLV-I tax Gene Product RL Science 241:89-92 (1988). XX // AC G000314 XX ID HS$IL3 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IL-3 XX DE interleukin-3 XX SY MCGF. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 5q23-q31 XX BC 6.1.5.9 XX BS -315 -173 R02734; HS$IL3_02; Binding factors: AP-1 . BS -315 -173 R02735; HS$IL3_03; Binding factors: NIP . BS -173 -61 R02736; HS$IL3_04; Binding factors: POU2F1 , ATF/CREB BS . BS -140 -133 R05026; HS$IL3_06; Binding factors: AML1c , AML1a BS , AML1 , PEBP2beta . BS -126 -109 R02682; HS$IL3_01; Binding factors: CD28RC , NF-GMa BS . BS -115 -105 R05027; HS$IL3_07. BS -76 -48 R04907; HS$IL3_05; Binding factors: EGR1 , DB1 BS . BS -53 -48 R05028; HS$IL3_08; Binding factors: AML1c , AML1a BS , AML1 . BS 129 158 R05054; HS$IL3_09; Binding factors: NF-ATp , NF-ATp BS . BS 179 207 R05055; HS$IL3_10; Binding factors: NF-ATp , NF-ATp BS . BS 179 207 R05056; HS$IL3_11; Binding factors: POU2F1 . BS 275 303 R05071; HS$IL3_12; Binding factors: AP-1 , c-Fos BS , c-Jun . BS 275 303 R05072; HS$IL3_13; Binding factors: NF-ATp , NF-ATp BS . XX DR EMBL: L10616; HSIL3AA. DR EMBL: M60870; HSIL3FL5. DR EMBL: U90652; HSU90652. DR TRANSPATH: G000314. DR TRANSCOMPEL: C00139. DR TRANSCOMPEL: C00160. DR TRANSCOMPEL: C00169. DR LOCUSLINK: 3562. DR OMIM: 147740. DR REFSEQ: NM_000588. XX RN [1] RX MEDLINE; 97188387. RA Uchida H., Zhang J., Nimer S. D. RT AML1A and AML1B can transactivate the human IL-3 promoter RL J. Immunol. 158:2251-2258 (1997). RN [2] RX MEDLINE; 97199263. RA Duncliffe K. N., Bert A. G., Vadas M. A., Cockerill P. N. RT A T cell-specific enhancer in the interleukin-3 locus is activated RT cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site RL Immunity 6:175-185 (1997). RN [3] RX MEDLINE; 94309629. RA Koyano-Nakagawa N., Nishida J., Baldwin D., Arai K.-I., Yokota T. RT Molecular cloning of a novel human cDNA encoding a zinc finger protein that RT binds to the interleukin-3 promoter RL Mol. Cell. Biol. 14:5099-5107 (1994). RN [4] RX MEDLINE; 94235850. RA Cameron S., Taylor D. S., TePas E. C., Speck N. A., Mathey-Prevot B. RT Identification of a critical regulatory site in the human interleukine-3 RT promoter by in vivo footprinting RL Blood 83:2851-2859 (1994). RN [5] RX MEDLINE; 93024377. RA Fraser J. D., Weiss A. RT Regulation of T-cell lymphokine gene transcription by the accessory RT molecule CD28 RL Mol. Cell. Biol. 12:4357-4363 (1992). RN [6] RX MEDLINE; 90258885. RA Shannon M. F., Pell L. M., Lenardo M. J., Kuczek E. S., Occhiodoro F. S., RA Dunn St. M., Vadas M. A. RT A Novel Tumor Necrosis Factor-Responsive Transcription Factor Which RT Recognizes a Regulatory Element in Hemopoietic Growth Factor Genes RL Mol. Cell. Biol. 10:2950-2959 (1990). RN [7] RX MEDLINE; 90311340. RA Mathey-Prevot B., Andrews N. C., Murphy H. S., Kreissman S. G., Nathan D. G. RT Positive and negative elements regulate human interleukin 3 expression RL Proc. Natl. Acad. Sci. USA 87:5046-5050 (1990). XX // AC G000315 XX ID HS$IL5 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IL-5 XX DE interleukin-5 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 5q23-q31 XX BC 6.1.5.9 XX BS -223 -214 R02684; HS$IL5_01; Binding factors: NF-GMa . BS -124 -106 R08175; HS$IL5_02. XX DR EMBL: J02971; HSIL5A01. DR TRANSPATH: G000315. DR TRANSCOMPEL: C00191. DR LOCUSLINK: 3567. DR OMIM: 147850. DR REFSEQ: NM_000879. XX RN [1] RX MEDLINE; 97341185. RA Stranick K. S., Zambas D. N., Uss A. S., Egan R. W., Billah M. M., Umland RA S. P. RT Identification of transcription factor binding sites important in the RT regulation of the human interleukin-5 gene RL J. Biol. Chem. 272:16453-16465 (1997). RN [2] RX MEDLINE; 95271007. RA Prieschl E. E., Gouilleux-Gruart V., Walker C., Harrer N. E., Baumruker T. RT A nuclear factor of activated T cell-like transcription factor in mast RT cells is involved in IL-5 gene regulation after IgE plus antigen stimulation RL J. Immunol. 154:6112-6119 (1995). RN [3] RX MEDLINE; 90258885. RA Shannon M. F., Pell L. M., Lenardo M. J., Kuczek E. S., Occhiodoro F. S., RA Dunn St. M., Vadas M. A. RT A Novel Tumor Necrosis Factor-Responsive Transcription Factor Which RT Recognizes a Regulatory Element in Hemopoietic Growth Factor Genes RL Mol. Cell. Biol. 10:2950-2959 (1990). XX // AC G000316 XX ID HS$IL6 XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD IL-6 XX DE interleukin-6 XX SY IFNB2; BSF2; BSF-2; BSF-2; IFNB2; BSF2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 7p21-p15 XX BC 6.1.5.9 XX BS -210 -201 R03551; HS$IL6_04; Binding factors: GR alpha , GR BS beta . BS -171 -144 R03552; HS$IL6_05; Binding factors: GR alpha , GR BS beta . BS -163 -139 R03136; HS$IL6_03; Binding factors: C/EBPbeta , BS C/EBPbeta , C/EBPdelta . BS -135 -132 R03553; HS$IL6_06. BS -83 -75 R08093; HS$IL6_11; Binding factors: C/EBPbeta . BS -78 -62 R01634; HS$IL6_01; Binding factors: NF-kappaB , RelA BS . BS -73 14 R01936; HS$IL6_02; Binding factors: NF-kappaB(-like) . BS -32 -25 R03554; HS$IL6_07. BS -28 -20 R03555; HS$IL6_08; Binding factors: GR alpha , GR beta BS . BS -9 13 R03556; HS$IL6_09; Binding factors: GR alpha , GR beta BS . BS -6 13 R03557; HS$IL6_10. XX DR EMBL: Y00081; HSBSF2. DR EMBL: M22111; HSIL6B. DR TRANSPATH: G000316. DR TRANSCOMPEL: C00152. DR TRANSCOMPEL: C00323. DR TRANSCOMPEL: C00324. DR TRRD: 00115. DR LOCUSLINK: 3569. DR OMIM: 147620. DR REFSEQ: NM_000600. XX RN [1] RX MEDLINE; 95263468. RA Yan S. F., Tritto I., Pinsky D., Liao H., Huang J., Fuller G., Brett J., RA May L., Stern D. RT Induction of interleukin 6 (IL-6) by hypoxia in vascular cells RL J. Biol. Chem. 270:11463-11471 (1995). RN [2] RX MEDLINE; 94193722. RA Brasier A. R., Kumar A. RT Identification of a novel determinant for basic domain-leucine zipper DNA RT binding activity in the acute-phase inducible nuclear factor-interleukin-6 RT transcription factor RL J. Biol. Chem. 269:10341-10351 (1994). RN [3] RA Zhang Y., Broser M., Rom W. N. RT Activation of the interleukin 6 gene by Mycobacterium tuberculosis or RT lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B RL Proc. Natl. Acad. Sci. USA 91:2225-2229 (1994). RN [4] RX MEDLINE; 94052130. RA Matsusaka T., Fujikawa K., Nishio Y., Mukaida N., Matsushima K., Kishimoto RA T., Akira S. RT Transcription factors NF-IL6 and NF-kappaB synergistically activate RT transcription of the inflammatory cytokines interleukin 6 and interleukin 8 RL Proc. Natl. Acad. Sci. USA 90:10193-10197 (1993). RN [5] RX MEDLINE; 92159071. RA Kinoshita S., Akira S., Kishimoto T. RT A member of the C/EBP family, NF-IL6beta, forms a heterodimer and RT transcriptionally synergizes with NF-IL6 RL Proc. Natl. Acad. Sci. USA 89:1473-1476 (1992). RN [6] RX MEDLINE; 90269225. RA Akira S., Isshiki H., Sugita T., Tanabe O., Kinoshita S., Nishio Y., RA Nakajima T., Hirano T., Kishimoto T. RT A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family RL EMBO J. 9:1897-1906 (1990). RN [7] RX MEDLINE; 90136569. RA Shimizu H., Mitomo K., Watanabe T., Okamoto S., Yamamoto K.-I. RT Involvment of a NK-kB-Like Transcription Factor in the Activation of the RT Interleukin-6 Gene by Inflammatory Lymphokines RL Mol. Cell. Biol. 10:561-568 (1990). RN [8] RX MEDLINE; 90287177. RA Zhang Y., Lin J.-X., Vilcek J. RT Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human RT fibroblasts involves activation of a nuclear factor binding to a RT kappaB-like sequence RL Mol. Cell. Biol. 10:3818-3823 (1990). RN [9] RX MEDLINE; 90220618. RA Libermann T. A., Baltimore D. RT Activation of interleukin-6 gene expression through the NF-kappaB RT transcription factor RL Mol. Cell. Biol. 10:2327-2334 (1990). RN [10] RX MEDLINE; 91042502. RA Ray A., LaForge S., Sehgal P. B. RT On the mechanism for efficient repression of the interleukin-6 promoter by RT glucocorticoids: Enhancer, TAT box, and RNA start site (Inr motif) occlusion RL Mol. Cell. Biol. 10:5736-5746 (1990). XX // AC G000317 XX ID HS$IL8 XX DT 14.06.1995 (created); dbo. DT 30.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD IL8 XX DE interleukin 8 XX SY SCYB8; LUCT; LECT; MDNCF; TSG-1; IL-8; interleukin-8. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q13-q21 XX BC 6.1.5.9 XX BS -905 -893 R05060; HS$IL8_03; Binding factors: FOXF1 . BS -94 -81 R02908; HS$IL8_01; Binding factors: C/EBPalpha . BS -81 -70 R02909; HS$IL8_02; Binding factors: NF-kappaB . XX DR EMBL: M28130; HSIL8A. DR EMBL: D14283; HSLUCT. DR TRANSPATH: G000317. DR TRANSCOMPEL: C00098. DR TRANSCOMPEL: C00357. DR TRRD: 00038. DR LOCUSLINK: 3576. DR OMIM: 146930. DR REFSEQ: NM_000584. XX RN [1] RX MEDLINE; 98145936. RA Peterson R. S., Linn L., Ye H., Zhou H., Overdier D. G., Costa R. H. RT The winged helix transcriptional activator HFH-8 is expressed in the RT mesoderm of the primitive streak stage of mouse embryos and its cellular RT derivatives RL Mech. Dev. 69:53-69 (1997). RN [2] RX MEDLINE; 94019390. RA Stein B., Baldwin jr A. S. RT Distinct mechanisms for regulation of the interleukin-8 gene involve RT synergism and cooperativity between C/EBP and NF-kappa B RL Mol. Cell. Biol. 13:7191-7198 (1993). RN [3] RX MEDLINE; 91065925. RA Mukaida N., Mahe Y., Matsushima K. RT Cooperative interaction of nuclear factor-kappaB and cis-regulatory RT enhancer binding protein-like factor binding elements in activating the RT interleukin-8 gene by pro-inflammatory cytokines RL J. Biol. Chem. 265:21128-21133 (1990). XX // AC G000318 XX ID HS$IGH XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IgH XX DE immunoglobulin heavy chain XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.5.11 XX BS empty empty R02894; HS$IGH_06. BS empty empty R11183; HS$IGH_07; Binding factors: STAT6 , STAT5A BS , STAT5B . BS -107 -93 R00833; HS$IGH_01; Binding factors: POU2F1 . BS -72 -51 R00834; HS$IGH_02; Binding factors: NF-A . BS 119 138 R00874; HS$IGH_03; Binding factors: 96K-protein , BS LyF-1 . BS 214 244 R00875; HS$IGH_04. BS 500 520 R00876; HS$IGH_05. XX DR EMBL: M20267; HSIGHBP. DR EMBL: X17116; HSJH. DR TRANSPATH: G000318. DR TRANSCOMPEL: C00173. XX RN [1] RX MEDLINE; 21125882. RA Ehret G. B., Reichenbach P., Schindler U., Horvath C. M., Fritz S., Nabholz RA M., Bucher P. RT DNA binding specificity of different STAT proteins. Comparison of in vitro RT specificity with natural target sites. RL J. Biol. Chem. 276:6675-6688 (2001). RN [2] RX MEDLINE; 92017799. RA Lo K., Landau N. R., Smale S. T. RT LyF-1, a transcriptional regulator that interacts with a novel class of RT promoters for lymphocytes-specific genes RL Mol. Cell. Biol. 11:5229-5243 (1991). RN [3] RX MEDLINE; 91094881. RA Wang J., Oketani M., Watanabe T. RT Positive and negative regulation of immunoglobulin gene expression by a RT novel B-cell-specific enhancer element RL Mol. Cell. Biol. 11:75-83 (1991). RN [4] RX MEDLINE; 88223366. RA Araki K., Maeda H., Wang J., Kitamura D., Watanabe T. RT Purification of a Nuclear Trans-Acting Factor Involved in the Regulation of RT a Human Immunoglobulin Heavy Chain Gene RL Cell 53:723-730 (1988). RN [5] RX MEDLINE; 88111566. RA Pruijn G. J. M., van Driel W., van Miltenburg R. T., van der Vliet P. C. RT Promoter and enhancer elements containing a conserved sequence motif are RT recognized by nuclear factor III, a protein stimulating adenovirus DNA RT replication RL EMBO J. 6:3771-3778 (1987). RN [6] RX MEDLINE; 88096556. RA Wang J., Nishiyama K., Araki K., Kitamura D., Watanabe T. RT Purification of an octamer sequence (ATGCAAAT)-binding protein from human B RT cells RL Nucleic Acids Res. 15:10105-10116 (1987). RN [7] RX MEDLINE; 87174814. RA Maeda H., Araki K., Kitamura D., Wang J., Watanabe T. RT Nuclear factors binding to the human immunoglobulin heavy-chain gene RT enhancer RL Nucleic Acids Res. 15:2851-2869 (1987). XX // AC G000319 XX ID HS$IGKL XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Ig-kappa XX DE immunoglobulin kappa light chain XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.5.12 XX BS empty empty R00896; HS$IGKL_01. BS empty empty R00897; HS$IGKL_02; Binding factors: NF-kappaE1 , BS NF-kappaE2 , NF-kappaE1 , NF-kappaE2 . BS empty empty R04163; HS$IGKL_08. BS empty empty R04164; HS$IGKL_09. BS empty empty R04165; HS$IGKL_10. BS empty empty R04166; HS$IGKL_11. BS -90 -83 R02751; HS$IGKL_07; Binding factors: kappaY factor . BS -65 0 R01637; HS$IGKL_05; Binding factors: POU2F2 . BS -65 0 R01638; HS$IGKL_06; Binding factors: POU2F1 . BS 3895 0 R01635; HS$IGKL_03; Binding factors: POU2F1 . BS 3895 0 R01636; HS$IGKL_04; Binding factors: POU2F2 . XX DR EMBL: X67858; HSIGKA. DR EMBL: K01325; HSIGKC2. DR EMBL: X59316; HSIGKL014. DR EMBL: X59318; HSIGKLV3B. DR EMBL: M64857; HSIGKV18B. DR TRANSPATH: G000319. DR SMARTDB: SM0000082. XX RN [1] RX MEDLINE; 93024467. RA Judde J.-G., Max E. E. RT Characterization of the human immunoglobulin kappa gene 3' enhancer: RT Functional importance of three motifs that demonstrate B-cell-specific in RT vivo footprints RL Mol. Cell. Biol. 12:5206-5216 (1992). RN [2] RX MEDLINE; 91006003. RA Atchison M. L., Delmas V., Perry R. P. RT A novel upstream element compensates for an ineffectual octamer motif in an RT immunoglobulin Vkappa promoter RL EMBO J. 9:3109-3117 (1990). RN [3] RX MEDLINE; 90287182. RA Nelms K., van Ness B. RT Identification of an Octamer-Binding Site in the Human Kappa Light-Chain RT Enhancer RL Mol. Cell. Biol. 10:3843-3846 (1990). RN [4] RX MEDLINE; 88262490. RA Gimble J. M., Flanagan J. R., Recker D., Max E. E. RT Identification and partial purification of a protein binding to the human RT immunoglobulin kappa enhancer kE2 site RL Nucleic Acids Res. 16:4967-4988 (1988). RN [5] RX MEDLINE; 87257882. RA Gimble J. M., Levens D., Max E. E. RT B-Cell Nuclear Proteins Binding In Vitro to the Human Immunoglobulin k RT Enhancer: Localization by Exonuclease Protection RL Mol. Cell. Biol. 7:1815-1822 (1987). XX // AC G000320 XX ID HS$INS XX DT 14.06.1995 (created); dbo. DT 27.09.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ins XX DE insulin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.5 XX BC 6.1.5.5 XX BS -277 -266 R02708; HS$INS_01. BS -262 -238 R08779; HS$INS_09; Binding factors: Pax-4a , Pax-4c BS . BS -248 -219 R04458; HS$INS_08; Binding factors: USF . BS -239 -234 R02707; HS$INS_02. BS -230 -201 R02709; HS$INS_03; Binding factors: IPF1 , IPF1 BS . BS -183 -179 R02710; HS$INS_04; Binding factors: CREB . BS -153 -123 R02711; HS$INS_05. BS -122 -93 R04457; HS$INS_07. BS -85 -71 R02712; HS$INS_06. XX DR EMBL: J00265; HSINS01. DR EMBL: J00266; HSINS1UA. DR EMBL: J00267; HSINS1UB. DR EMBL: M26868; HSINSHVR. DR EMBL: M10039; HSINSPR. DR EMBL: L15440; HSINSTHIG. DR EMBL: V00565; HSINSU. DR TRANSPATH: G000320. DR LOCUSLINK: 3630. DR OMIM: 176730. DR REFSEQ: NM_000207. XX RN [1] RX MEDLINE; 20069445. RA Campbell S. C., Cragg H., Elrick L. J., Macfarlane W. M., Shennan K. I., RA Docherty K. RT Inhibitory effect of Pax4 on the human insulin and islet amyloid RT polypeptide (IAPP) promoters RL FEBS Lett. 463:53-57 (1999). RN [2] RX MEDLINE; 97400587. RA Macfarlane W. M., Smith S. B., James R. F., Clifton A. D., Doza Y. N., RA Cohen P., Docherty K. RT The p38/reactivating kinase mitogen-activated protein kinase RT cascademediates the activation of the transcription factor insulin RT upstreamfactor 1 and insulin gene transcription by high glucose in RT pancreaticbeta-cells RL J. Biol. Chem. 272:20936-20944 (1997). RN [3] RX MEDLINE; 94029918. RA Read M. L., Clark A. R., Docherty K. RT The helix-loop-helix transcription factor USF (upstream stimulating factor) RT binds to a regulatory sequence of the human insulin gene enhancer RL Biochem. J. 295:233-237 (1993). RN [4] RX MEDLINE; 92008678. RA Scott V., Clark A. R., Hutton J. C., Docherty K. RT Two proteins act as the IUF1 insulin gene enhancer binding factor RL FEBS Lett. 290:27-30 (1991). RN [5] RX MEDLINE; 90243713. RA Boam D. S. W., Clark A. R., Docherty K. RT Positive and Negative Regulation of the Human Insulin Gene by Multiple RT Trans-acting Factors RL J. Biol. Chem. 265:8285-8296 (1990). RN [6] RX MEDLINE; 90104279. RA Boam D. S., Docherty K. RT A tissue-specific nuclear factor binds to multiple sites in the human RT insulin-gene enhancer RL Biochem. J. 264:233-239 (1989). XX // AC G000321 XX ID HS$INSR XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IR XX DE insulin receptor XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 19p13.3-p13.2 XX BC 6.1.5.13 XX BS -1316 -1297 R03068; HS$INSR_01; Binding factors: C/EBPalpha . BS -618 -593 R03287; HS$INSR_03; Binding factors: Sp1 . BS 324 343 R03069; HS$INSR_02; Binding factors: C/EBPalpha . XX DR EMBL: M23100; HSINSR03. DR EMBL: J03466; HSINSRB. DR EMBL: J05043; HSIRSRE. DR TRANSPATH: G000321. DR TRRD: 00170. DR LOCUSLINK: 3643. DR OMIM: 147670. DR REFSEQ: NM_000208. XX RN [1] RX MEDLINE; 91128408. RA McKeon C., Pham T. RT Transactivation of the human insulin receptor gene by the CAAT/enhancer RT binding protein RL Biochem. Biophys. Res. Commun. 174:721-728 (1991). RN [2] RX MEDLINE; 91139695. RA Araki E., Murakami T., Shirotani T., Kanai F., Shinohara Y., Shimada F., RA Mori M., Shichiri M., Ebina Y. RT A cluster of four Sp1 binding sites required for efficient expression of RT the human insulin receptor gene RL J. Biol. Chem. 266:3944-3948 (1991). XX // AC G000322 XX ID HS$IL2RB XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD IL-2Rb XX DE interleukin-2 receptor beta chain XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 22q13 XX BC 6.1.5.15 XX DR TRANSPATH: G000322. DR TRRD: 00181. DR LOCUSLINK: 3560. DR OMIM: 146710. DR REFSEQ: NM_000878. XX // AC G000323 XX ID HS$IFP53 XX DT 21.05.1996 (created); ake. DT 16.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD IFP 53 XX DE tryptophanyl-tRNA synthetase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 14q21-qter XX BC 6.1.4.3 XX DR BRENDA: 6.1.1.2; Human. DR TRRD: 00201. DR LOCUSLINK: 7453. DR OMIM: 191050. DR REFSEQ: NM_004184. XX // AC G000324 XX ID HS$IRF1 XX DT 14.06.1995 (created); dbo. DT 07.11.2001 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD IRF-1 XX DE interferon regulatory factor 1 XX SY ISGF2; IRF1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 5q23-q31 XX BC 6.1.2.2.4 XX BS -130 -107 R12315; HS$IRF1_02; Binding factors: IPCS-BF . BS -127 -107 R04223; HS$IRF1_01; Binding factors: STAT1alpha , BS STAT3 , STAT1beta , STAT3 , STAT1 . XX FA T00423; IRF1. XX DR EMBL: X53095; HSIRF1A. DR EMBL: L05078; HSIRFI. DR TRANSPATH: G000324. DR TRANSCOMPEL: C00192. DR TRANSCOMPEL: C00307. DR TRRD: 00276. DR LOCUSLINK: 3659. DR OMIM: 147575. DR REFSEQ: NM_002198. XX RN [1] RX MEDLINE; 98037811. RA Lallemand C., Bayat-Sarmadi M., Blanchard B., Tovey M. G. RT Identification of a novel transcriptional regulatory element common to the RT p53 and interferon regulatory factor 1 genes. RL J. Biol. Chem. 272:29801-29809 (1997). RN [2] RX MEDLINE; 94222041. RA Harroch S., Revel M., Chebath J. RT Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene RT expression through the palindromic interferon response element pIRE and RT cell type-dependent control of IRF-1 binding to DNA RL EMBO J. 13:1942-1949 (1994). XX // AC G000325 XX ID HS$ISG15 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ISG15 XX DE interferon-stimulated gene 15 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1 XX BC 6.1.7.2 XX BS -115 -39 R00945; HS$ISG15_01; Binding factors: ISGF-1 . BS -115 -39 R00946; HS$ISG15_02; Binding factors: IRF1 . BS -115 -39 R00947; HS$ISG15_03; Binding factors: GAF , ISGF-3 BS . BS -111 -94 R00948; HS$ISG15_04; Binding factors: ISGF-1 . BS -111 -94 R00949; HS$ISG15_05; Binding factors: IRF1 , ISGF-3 BS , ISGF-3alpha , ISGF-3gamma . XX DR EMBL: M31020; HSISGA01. DR TRANSPATH: G000325. DR TRRD: 00278. DR LOCUSLINK: 9636. XX RN [1] RX MEDLINE; 94165108. RA Cook J. R., Emanuel S. L., Donnelly R. J., Soh J., Mariano T. M., Schwartz RA B., Rhee S., Pestka S. RT Sublocalization of the human interferon-gamma receptor accessory factor RT gene and characterization of accessory factor activity by yeast artificial RT chromosomal fragmentation RL J. Biol. Chem. 269:7013-7018 (1994). RN [2] RX MEDLINE; 93087537. RA Gutch M. J., Daly C., Reich N. C. RT Tyrosine phosphorylation is required for activation of an alpha RT interferon-stimulated transcription factor RL Proc. Natl. Acad. Sci. USA 89:11411-11415 (1992). RN [3] RX MEDLINE; 93024438. RA Kanda K., Decker T., Aman P., Wahlstroem M., von Gabain A., Kallin B. RT The EBNA2-related resistance towards alpha interferon (IFN-alpha) in RT Burkitt's lymphoma cells effects induction of IFN-induced genes but not the RT activation of transcription factor ISGF-3 RL Mol. Cell. Biol. 12:4930-4936 (1992). RN [4] RX MEDLINE; 93024392. RA Petricoin III E. F., Hackett R. H., Akai H., Igarashi K., Finbloom D. S., RA Larner A. C. RT Modulation of interferon signaling in human fibroblasts by phorbol esters RL Mol. Cell. Biol. 12:4486-4495 (1992). RN [5] RX MEDLINE; 92097537. RA Nielsch U., Zimmer S. G., Babiss L. E. RT Changes in NF-kappaB and ISGF3 binding activities are responsible for RT differences in MHC and beta-IFN gene expression in Ad5- versus RT Ad12-transformed cells RL EMBO J. 10:4169-4175 (1991). RN [6] RX MEDLINE; 92078229. RA Kessler D. S., Levy D. E. RT Protein kinase activity required for an early step in interferon-alpha RT signaling RL J. Biol. Chem. 266:23471-23476 (1991). RN [7] RX MEDLINE; 91376056. RA Gutch M. J., Reich N. C. RT Repression of the interferon signal transduction pathway by the adenovirus RT E1A oncogene RL Proc. Natl. Acad. Sci. USA 88:7913-7917 (1991). RN [8] RX MEDLINE; 90214619. RA Levy D. E., Lew D. J., Decker T., Kessler D. S., Darnell jr J. E. RT Synergistic interaction between interferon-alpha and interferon-gamma RT through induced synthesis of one subunit of the transcription factor ISGF3 RL EMBO J. 9:1105-1111 (1990). RN [9] RX MEDLINE; 91065521. RA Kessler D. S., Veals S. A., Fu X.-Y., Levy D. E. RT Interferon-alpha regulates nuclear translocation and DNA-binding affinity RT of ISGF3, a multimeric transcriptional activator RL Genes Dev. 4:1753-1765 (1990). RN [10] RX MEDLINE; 90258828. RA Pine R., Decker T., Kessler D. S., Levy D. E., Darnell J. E. RT Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): RT ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and RT Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator RT of Either RL Mol. Cell. Biol. 10:2448-2457 (1990). RN [11] RX MEDLINE; 90108685. RA Levy D. E., Kessler D. S., Pine R., Darnell jr J. E. RT Cytoplasmic activation of ISGF3, the positive regulator of RT interferon-alpha-stimulated transcription, reconstituted in vitro RL Genes Dev. 3:1362-1371 (1989). RN [12] RX MEDLINE; 89380290. RA Raj N. B. K., Engelhardt J., Au W.-C., Levy D. E., Pitha P. M. RT Virus Infection and Interferon Can Activate Gene Expression Through a RT Single Synergistic Element, but Endogenous Genes Show Distinct Regulation RL J. Biol. Chem. 264:16658-16666 (1989). RN [13] RX MEDLINE; 90014810. RA Pine R., Darnell J. E. RT In Vivo Evidence of Interaction between Interferon-Stimulated Gene Factors RT and the Interferon-Stimulated Response Element RL Mol. Cell. Biol. 9:3533-3537 (1989). RN [14] RX MEDLINE; 89263782. RA Reich N. C., Darnell jr J. E. RT Differential binding of interferon-induced factors to an oligonucleotide RT that mediates transcriptional activation RL Nucleic Acids Res. 17:3415-3424 (1989). RN [15] RX MEDLINE; 89091125. RA Kessler D. S., Pine R., Pfeffer L. M., Levy D. E., Darnell jr J. E. RT Cells resistant to interferon are defective in activation of a RT promoter-binding factor RL EMBO J. 7:3779-3783 (1988). RN [16] RX MEDLINE; 89042213. RA Kessler D. S., Levy D. E., Darnell jr J. E. RT Two interferon-induced nuclear factors bind a single promoter element in RT interferon-stimulated genes RL Proc. Natl. Acad. Sci. USA 85:8521-8525 (1988). XX // AC G000326 XX ID HS$ISG54 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ISG54 XX DE interferon-stimulated gene 54 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.7.2 XX BS -103 -84 R00950; HS$ISG54_01; Binding factors: ICSBP , IRF1 BS , IRF1 , ISGF-3 . BS -17 -5 R04218; HS$ISG54_02. XX DR EMBL: X07557; HSIFI54. DR TRANSPATH: G000326. DR TRRD: 00279. XX RN [1] RX MEDLINE; 93024392. RA Petricoin III E. F., Hackett R. H., Akai H., Igarashi K., Finbloom D. S., RA Larner A. C. RT Modulation of interferon signaling in human fibroblasts by phorbol esters RL Mol. Cell. Biol. 12:4486-4495 (1992). RN [2] RX MEDLINE; 90258828. RA Pine R., Decker T., Kessler D. S., Levy D. E., Darnell J. E. RT Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): RT ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and RT Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator RT of Either RL Mol. Cell. Biol. 10:2448-2457 (1990). RN [3] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [4] RX MEDLINE; 91046034. RA Fu X.-Y., Kessler D. S., Veals S. A., Levy D. E., Darnell jr J. E. RT ISGF3, the transcriptional activator induced by interferon alpha, consists RT of multiple interacting polypeptide chains RL Proc. Natl. Acad. Sci. USA 87:8555-8559 (1990). RN [5] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [6] RX MEDLINE; 89042213. RA Kessler D. S., Levy D. E., Darnell jr J. E. RT Two interferon-induced nuclear factors bind a single promoter element in RT interferon-stimulated genes RL Proc. Natl. Acad. Sci. USA 85:8521-8525 (1988). XX // AC G000327 XX ID HS$LCK XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD lck XX DE lymphocyte-specific protein-tyrosine kinase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1p35-p32 XX BC 6.1.5.13 XX BS -187 -179 R03518; HS$LCK_01; Binding factors: LyF-1 . BS -163 -155 R03519; HS$LCK_02; Binding factors: LyF-1 . XX DR EMBL: M21510; HSLCKA. DR TRANSPATH: G000327. DR TRANSCOMPEL: C00240. DR BRENDA: 2.7.1.112. DR LOCUSLINK: 3932. DR OMIM: 153390. DR REFSEQ: NM_005356. XX RN [1] RX MEDLINE; 92017799. RA Lo K., Landau N. R., Smale S. T. RT LyF-1, a transcriptional regulator that interacts with a novel class of RT promoters for lymphocytes-specific genes RL Mol. Cell. Biol. 11:5229-5243 (1991). XX // AC G000329 XX ID HS$LPL XX DT 14.06.1995 (created); dbo. DT 19.10.2000 (updated); bme. CO Copyright (C), Biobase GmbH. XX SD LPL XX DE lipoprotein lipase XX SY LIPD. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 8p22 XX BC 6.1.4.6 XX BS empty empty R09492; HS$LPL_04. BS -692 -668 R04232; HS$LPL_01. BS -468 -430 R04233; HS$LPL_02. BS -46 -39 R09467; HS$LPL_03; Binding factors: POU2F1 . XX DR EMBL: X68111; HSLIPLP. DR EMBL: M29549; HSLPLA. DR TRANSPATH: G000329. DR PATHODB: MR000028. DR PATHODB: MR000029. DR BRENDA: 3.1.1.34; Human. DR TRRD: 00421. DR LOCUSLINK: 4023. DR OMIM: 238600. DR REFSEQ: NM_000237. XX RN [1] RX MEDLINE; 98012714. RA Hall S., Chu G., Miller G., Cruickshank K., Cooper J. A., Humphries S. E., RA Talmud P. J. RT A common mutation in the lipoprotein lipase gene promoter, -93T/G, is RT associated with lower plasma triglyceride levels and increased promoter RT activity in vitro RL Arterioscler. Thromb. Vasc. Biol. 17:1969-1976 (1997). RN [2] RX MEDLINE; 93024407. RA Enerbaeck S., Ohlsson B. G., Samuelson L., Bjursell G. RT Characterization of the human lipoprotein lipase (LPL) promoter: Evidence RT of two cis-regulatory regions, LP-alpha and LP-beta, of importance for the RT differentiation-linked induction of the LPL gene during adipogenesis RL Mol. Cell. Biol. 12:4622-4633 (1992). RN [3] RX MEDLINE; 92011666. RA Previato L., Parrott C. L., Santamarina-Fojo S., Brewer HB J. r. RT Transcriptional regulation of the human lipoprotein lipase gene in 3T3-L1 RT adipocytes RL J. Biol. Chem. 266:18958-18963 (1991). XX // AC G000330 XX ID HS$LYN XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD lyn XX SY JTK8; JTK8. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 8q13 XX BS empty empty R12017; HS$LYN_02; Binding factors: ELF-1 , Tel-2b BS , Tel-2a , Tel-2c , NERF-1a , NERF-1b BS , NERF-2 . BS -54 -6 R04234; HS$LYN_01; Binding factors: POU2F1 , POU2F2 BS . XX DR EMBL: S43167; S43167. DR TRANSPATH: G000330. DR LOCUSLINK: 4067. DR OMIM: 165120. DR REFSEQ: NM_002350. XX RN [1] RX MEDLINE; 21153768. RA Gu X., Shin B. H., Akbarali Y., Weiss A., Boltax J., Oettgen P., Libermann RA T. A. RT Tel-2 is a novel transcriptional repressor related to the Ets factor RT Tel/ETV-6 RL J. Biol. Chem. 276:9421-9436 (2001). RN [2] RX MEDLINE; 96347578. RA Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T. A. RT Characterization of NERF, a novel transcription factor related to the Ets RT factor ELF-1 RL Mol. Cell. Biol. 16:5091-5106 (1996). RN [3] RX MEDLINE; 92375046. RA Uchiumi F., Semba K., Yamanashi Y., Fujisawa J.-I., Yoshida M., Inoue K., RA Toyoshima K., Yamamoto T. RT Characterization of the promoter region of the src family gene lyn and its RT trans activation by human T-cell leukemia virus type I-encoded p40tax RL Mol. Cell. Biol. 12:3784-3795 (1992). XX // AC G000331 XX ID HS$M2DQA XX DT 21.05.1996 (created); ake. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HLA-DQA XX DE MHC class II human leukocyte antigen DQalpha chain XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.6.5.3.2 XX DR TRRD: 00206. DR LOCUSLINK: 3117. DR OMIM: 146880. DR REFSEQ: NM_002122. XX // AC G000332 XX ID HS$MBP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MBP XX DE myelin basic protein XX SY RK187; RK41. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 18q23 XX BC 6.1.2.11 XX BS -636 -614 R11177; HS$MBP_08; Binding factors: Nkx6-2 . BS -621 -601 R11176; HS$MBP_07; Binding factors: Nkx6-2 . BS -287 -249 R02774; HS$MBP_01. BS -250 -210 R03669; HS$MBP_04. BS -169 -130 R02775; HS$MBP_02. BS -131 -94 R03670; HS$MBP_05. BS -50 -14 R02776; HS$MBP_03. BS -37 -14 R03671; HS$MBP_06. XX DR EMBL: M63599; HSMBP1A1. DR TRANSPATH: G000332. DR LOCUSLINK: 4155. DR OMIM: 159430. DR REFSEQ: NM_002385. XX RN [1] RX MEDLINE; 97402511. RA Awatramani R., Scherer S., Grinspan J., Collarini E., Skoff R., O'Hagan D., RA Garbern J., Kamholz J. RT Evidence that the homeodomain protein Gtx is involved in the regulation of RT oligodendrocyte myelination RL J. Neurosci. 17:6657-6668 (1997). RN [2] RX MEDLINE; 90337999. RA Devine-Beach K., Lashgari M. S., Khalili K. RT Myelin basic protein gene transcription: Identification of proximal and RT distal cis-acting regulatory elements RL J. Biol. Chem. 265:13830-13835 (1990). RN [3] RX MEDLINE; 91056172. RA Lashgari M. S., Devine-Beach K., Haas S., Khalili K. RT Nuclear proteins in mouse brain cells bind specifically to the myelin basic RT protein regulatory region RL J. Clin. Invest. 86:1671-1677 (1990). XX // AC G000333 XX ID HS$MTF XX DT 21.05.1996 (created); ake. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MTf XX DE melanotransferrin, p97 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.5.15 XX DR TRRD: 00081. XX // AC G000335 XX ID HS$MT1F XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD MT-IF XX DE metallothionein IF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 16q13 XX BC 6.1.6.1 XX BS -147 -111 R03196; HS$MT1F_01. XX DR EMBL: M10943; HSMETIF. DR LOCUSLINK: 4494. DR OMIM: 156352. XX RN [1] RX MEDLINE; 91236768. RA Foster R., Gedamu L. RT Functional analyses of promoter elements responsible for the differential RT expression of the human metallothionein (MT)-IG and MT-IF genes RL J. Biol. Chem. 266:9866-9875 (1991). XX // AC G000336 XX ID HS$MT1G XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD MT-IG XX DE metallothionein IG XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 16q13 XX BC 6.1.6.1 XX BS -161 -105 R03197; HS$MT1G_01. BS -105 -37 R03198; HS$MT1G_02. XX DR EMBL: J03910; HSMT2A. DR LOCUSLINK: 4495. DR OMIM: 156353. DR REFSEQ: NM_005950. XX RN [1] RX MEDLINE; 91236768. RA Foster R., Gedamu L. RT Functional analyses of promoter elements responsible for the differential RT expression of the human metallothionein (MT)-IG and MT-IF genes RL J. Biol. Chem. 266:9866-9875 (1991). XX // AC G000337 XX ID HS$MT2A XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MT-IIA XX DE metallothionein IIA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 16q13-q22.1 XX BC 6.1.6.1 XX BS -309 -284 R08296; HS$MT2A_14; Binding factors: MTF-1 . BS -266 -242 R01030; HS$MT2A_01; Binding factors: GR . BS -249 -224 R08299; HS$MT2A_16; Binding factors: MTF-1 . BS -230 -165 R01031; HS$MT2A_02; Binding factors: AP-2alphaA , BS AP-2alphaB . BS -224 -203 R01032; HS$MT2A_03; Binding factors: AP-2alphaA , BS AP-2 , AP-2alphaB , AP-2beta . BS -190 0 R01033; HS$MT2A_04. BS -190 -167 R01034; HS$MT2A_05; Binding factors: AP-2alphaA , BS AP-2 , AP-2alphaB , AP-2beta , AP-2gamma . BS -177 -152 R08295; HS$MT2A_13; Binding factors: MTF-1 . BS -157 -132 R08298; HS$MT2A_15; Binding factors: MTF-1 , MTF-1 BS . BS -130 -110 R01035; HS$MT2A_06; Binding factors: AP-2alphaA , BS AP-2alphaB . BS -110 -80 R01036; HS$MT2A_07; Binding factors: AP-1 . BS -109 -90 R01037; HS$MT2A_08; Binding factors: AP-1 , AP-1 BS , c-Fos , c-Fos , c-Jun , c-Jun , BS Fra-1 , v-Jun , Fra-1 . BS -104 -84 R01038; HS$MT2A_09; Binding factors: AP-4 . BS -95 -70 R08294; HS$MT2A_12; Binding factors: MTF-1 . BS -72 -57 R01039; HS$MT2A_10; Binding factors: Sp1 . BS -61 -36 R08293; HS$MT2A_11; Binding factors: MTF-1 . XX DR EMBL: J00271; HSMET2. DR EMBL: M15244; HSMET2AA. DR EMBL: J03910; HSMT2A. DR EMBL: X00504; HSTHIO2A. DR TRANSPATH: G000337. DR TRRD: 00071. DR LOCUSLINK: 4502. DR OMIM: 156360. DR REFSEQ: NM_005953. XX RN [1] RX MEDLINE; 99192807. RA Koizumi S., Suzuki K., Ogra Y., Yamada H., Otsuka F. RT Transcriptional activity and regulatory protein binding of metal-responsive RT elements of the human metallothionein-IIA gene. RL Eur. J. Biochem. 259:635-642 (1999). RN [2] RX MEDLINE; 96251056. RA Oulad-Abdelghani M., Bouillet P., Chazaud C., Dolle P., Chambon P. RT AP-2.2: a novel AP2-related transcription factor induced by retinoic acid RT during differentiation of P19 embryonal carcinoma cells RL Exp. Cell Res. 225:338-347 (1996). RN [3] RX MEDLINE; 96038090. RA Moser M., Imhof A., Pscherer A., Bauer R., Amselgruber W., Sinowatz F., RA Schule R., Buettner R. RT Cloning and characterization of a second AP-2 transcription factor: AP-2 RT beta RL Development 121:2779-2788 (1995). RN [4] RX MEDLINE; 95160667. RA Takeda K., Fujita H., Shibahara S. RT Differential control of the metal-mediated activation of the human heme RT oxygenase-1 and metallothionein IIA genes. RL Biochem. Biophys. Res. Commun. 207:160-167 (1995). RN [5] RX MEDLINE; 94375478. RA Otsuka F., Iwamatsu A., Suzuki K., Ohsawa M., Hamer D. H., Koizumi S. RT Purification and characterization of a protein that binds to metal RT responsive elements of the human metallothionein IIA gene. RL J. Biol. Chem. 269:23700-23707 (1994). RN [6] RX MEDLINE; 93092992. RA Koizumi S., Yamada H., Suzuki K., Otsuka F. RT Zinc-specific activation of a HeLa cell nuclear protein which interacts RT wich a metal responsive element of the human metallothionein-IIA gene RL Eur. J. Biochem. 210:555- 560 (1992). RN [7] RX MEDLINE; 91288197. RA Mondesert G., Kedinger C. RT Cooperation between upstream and downstream elements of the adenovirus RT major late promoter for maximal late phase-specific transcription RL Nucleic Acids Res. 19:3221 (1991). RN [8] RX MEDLINE; 91334134. RA Labbe S., Prevost J., Remondelli P., Leone A., Seguin C. RT A nuclear factor binds to the metal regulatory elements of the mouse gene RT encoding metallothionein-I RL Nucleic Acids Res. 19:4225-4231 (1991). RN [9] RX MEDLINE; 90221800. RA Auwerx J., Staels B., Sassone-Corsi P. RT Coupled and uncoupled induction of fos and jun transcription by different RT second messengers in cells of hematopoietic origin RL Nucleic Acids Res. 18:221-228 (1990). RN [10] RX MEDLINE; 90138931. RA Abate C., Luk D., Gentz R., Rauscher III F. J., Curran T. RT Expression and purification of the leucine zipper and DNA-binding domains RT of Fos and Jun: Both Fos and Jun contact DNA directly RL Proc. Natl. Acad. Sci. USA 87:1032-1036 (1990). RN [11] RX MEDLINE; 90301477. RA Naranjo J. R., Mellstroem B., Auwerx J., Mollinedo F., Sassone-Corsi P. RT Unusual c-fos induction upon chromaffin PC12 differentiation by sodium RT butyrate: loss of fos autoregulatory function RL Nucleic Acids Res. 18:3605-3610 (1990). RN [12] RX MEDLINE; 90076144. RA Macchi M., Bornert J.-M., Davidson I., Kanno M., Rosales R., Vigneron M., RA Xiao J.-H., Fromental C., Chambon P. RT The SV40 TC-II(kappaB) enhanson binds ubiquitous and cell type specifically RT inducible nuclear proteins from lymphoid and non-lymphoid cell lines RL EMBO J. 8:4215-4227 (1989). RN [13] RX MEDLINE; 89306614. RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M. RT Fos-Jun interaction: mutational analysis of the leucine zipper domain of RT both proteins RL Genes Dev. 3:770-781 (1989). RN [14] RX MEDLINE; 89232714. RA Cohen D. R., Ferreira P. C. P., Gentz R., Franza B. R., Curran T. RT The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 RT site with Jun: transcription factor AP-1 is comprised of multiple protein RT complexes RL Genes Dev. 3:172-184 (1989). RN [15] RX MEDLINE; 90040820. RA Sonnenberg J. L., Mitchelmore C., Macgregor-Leon P. F., Hempstead J., RA Morgan J. I., Curran T. RT Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 RL J. Neurosci. Res. 24:72-80 (1989). RN [16] RX MEDLINE; 90380378. RA Sonnenberg J. L., Macgregor-Leon P. F., Curran T., Morgan J. I. RT Dynamic alternations occur in the levels and composition of transcription RT factor AP-1 complexes after seizure RL Neuron 3:359-365 (1989). RN [17] RX MEDLINE; 89160319. RA Rittling S. R., Coutinho L., Amram T., Kolbe M. RT Ap-1/jun binding sites mediate serum inducibility of the human vimentin RT promoter RL Nucleic Acids Res. 17:1619 (1989). RN [18] RX MEDLINE; 89186917. RA Turner R., Tjian R. RT Leucine repeats and an adjacent DNA binding domain mediate the formation of RT functional cFos-cJun heterodimers RL Science 243:1689-1694 (1989). RN [19] RX MEDLINE; 89186918. RA Gentz R., Rauscher III F. J., Abate C., Curan T. RT Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding RT domains RL Science 243:1695-1699 (1989). RN [20] RX MEDLINE; 88295130. RA Sassone-Corsi P., Lamph W. W., Kamps M., Verma I. M. RT fos-associated cellular p39 is related to nuclear transcription factor AP-1 RL Cell 54:553-560 (1988). RN [21] RX MEDLINE; 89107991. RA Williams T., Admon A., Luescher B., Tjian R. RT Cloning and expression of AP-2, a cell-type-specific transcription factor RT that activates inducible enhancer elements RL Genes Dev. 2:1557-1569 (1988). RN [22] RX MEDLINE; 89196887. RA Rauscher III F. J., Voulalas P. J., Franza jr B. R., Curran T. RT Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro RL Genes Dev. 2:1687-1699 (1988). RN [23] RX MEDLINE; 88156935. RA Angel P., Allegretto E. A., Okino S. T., Hattori K., Boyle W. J., Hunter RA T., Karin M. RT Oncogene jun encodes a sequence-specific trans-activator similar to AP-1 RL Nature 332:166-171 (1988). RN [24] RX MEDLINE; 88189275. RA Mermod N., Williams T. J., Tjian R. RT Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late RT transcription in vitro RL Nature 332:557-561 (1988). RN [25] RX MEDLINE; 88176887. RA Harrington M., Jones P. A., Imagawa M., Karin M. RT Cytosine methylation does not affect binding of transcription factor Sp1 RL Proc. Natl. Acad. Sci. USA 85:2066-2070 (1988). RN [26] RX MEDLINE; 88027009. RA Imagawa M., Chiu R., Karin M. RT Transcription factor AP-2 mediates induction by two different signal RT transduction pathways: Protein kinase C and cAMP RL Cell 51:251-260 (1987). RN [27] RX MEDLINE; 87301729. RA Mitchell P., Wang C., Tjian R. RT Positive and Negative Regulation of Transcription In Vitro: RT Enhancer-Binding Protein AP-2 Is Inhibited by SV40 T Antigen RL Cell 50:847-861 (1987). RN [28] RX MEDLINE; 87115798. RA Lee W., Haslinger A., Karin M., Tjian R. RT Activation of transcription by two factors that bind promoter and enhancer RT sequences of the human metallothionein gene and SV40 RL Nature 325:368-372 (1987). RN [29] RX MEDLINE; 84168159. RA Karin M., Haslinger A., Holtgreve H., Richards R. I., Krauter P., Westphal RA H. M., Beato M. RT Characterization of DNA sequences through which cadmium and glucocorticoid RT hormones induce human metallothionein-IIA gene RL Nature 308:513-519 (1984). XX // AC G000338 XX ID HS$M1A3 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HLA-A3 XX DE MHC class I human leukocyte antigen A3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.6.5.3.1 XX BS -107 -85 R01085; HS$M1A3_01. XX DR EMBL: X00492; HSHLIA. DR TRRD: 00342. XX RN [1] RX MEDLINE; 91187669. RA Roy Ch., Lebleu B. RT DNA protein interactions at the interferon-responsive promoter elements: RT potential for a H-DNA conformation RL Nucleic Acids Res. 19:517 (1991). RN [2] RX MEDLINE; 90245659. RA Roy C., Lebleu B. RT DNA-protein interactions at the interferon-responsive promoter: evidences RT for an involvement of phosphorylation RL Nucleic Acids Res. 18:2125-2131 (1990). XX // AC G000339 XX ID HS$M1B7 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HLA-B7 XX DE MHC class I human leukocyte antigen B7 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6 XX BC 6.1.6.5.3.1 XX BS -184 -172 R04229; HS$M1B7_01. BS -164 -156 R04230; HS$M1B7_02. BS -121 -108 R04231; HS$M1B7_03. XX DR EMBL: S68087; S68087. DR TRANSCOMPEL: C00060. DR TRRD: 00185. DR LOCUSLINK: 112959. XX RN [1] RX MEDLINE; 92334360. RA Dey A., Thornton A. M., Lonergan M., Weissman S. M., Chamberlain J. W., RA Ozato K. RT Occupancy of upstream regulatory sites in vivo coincides with major RT histocompatibility complex class I gene expression in mouse tissues RL Mol. Cell. Biol. 12:3590- 3599 (1992). XX // AC G000340 XX ID HS$M2DPA XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HLA-DPA XX DE MHC class II human leukocyte antigen DPalpha XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.6.5.3.2 XX BS -119 -65 R02384; HS$M2DPA_01; Binding factors: RFX , RFX1 BS , RFX2 , RFX2 , RFX3 , RFX3 , RFX1 BS . XX DR TRANSPATH: G000340. DR TRRD: 00204. DR LOCUSLINK: 3113. DR OMIM: 142880. DR REFSEQ: NM_033554. XX RN [1] RX MEDLINE; 91071581. RA Reith W., Herrero-Sanchez C., Kobr M., Silacci P., Berte Ch., Barras E., RA Fey S., Mach B. RT MHC class II regulatory factor RFX has a novel DNA-binding domain and a RT functionally independent dimerization domain RL Genes Dev. 4:1528-1540 (1990). XX // AC G000341 XX ID HS$M2DRB XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HLA-DRB XX DE MHC class II human leukocyte antigen DRbeta XX SY HLA-DRB1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6 XX BC 6.1.6.5.3.2 XX BS 313 362 R03694; HS$M2DRB_01; Binding factors: X2BP . XX DR EMBL: X65569; HSDRB12. DR EMBL: X65568; HSDRB17. DR EMBL: X65587; HSHLADRB3. DR EMBL: M20548; HSMHDR1. DR TRANSPATH: G000341. DR TRRD: 00208. DR LOCUSLINK: 112877. XX RN [1] RX MEDLINE; 92066479. RA Hasegawa S. L., Boss J. M. RT Two B cell factors bind the HLA-DRA X box region and recognize different RT subsets of HLA class II promoters RL Nucleic Acids Res. 19:6269-6276 (1991). XX // AC G000342 XX ID HS$M2DPB XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HLA-DPB XX DE MHC class II human leukocyte antigen DPbeta XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.6.5.3.2 XX BS -131 -82 R03105; HS$M2DPB_01; Binding factors: c-Fos , XBP-1 BS , X2BP . XX DR TRANSPATH: G000342. DR TRRD: 00205. XX RN [1] RX MEDLINE; 92066479. RA Hasegawa S. L., Boss J. M. RT Two B cell factors bind the HLA-DRA X box region and recognize different RT subsets of HLA class II promoters RL Nucleic Acids Res. 19:6269-6276 (1991). RN [2] RX MEDLINE; 91239556. RA Ono S. J., Bazil V., Levi B.-Z., Ozato K., Strominger J. L. RT Transcription of a subset of human class II major histocompatibility RT complex genes is regulated by a nucleoprotein complex that contains c-fos RT or an antigenically related protein RL Proc. Natl. Acad. Sci. USA 88:4304-4308 (1991). RN [3] RX MEDLINE; 91239557. RA Ono S. J., Liou H.-C., Davidon R., Strominger J. L., Glimcher L. H. RT Human X-box-binding protein 1 is required for the transcription of a subset RT of human class II major histocompatibility gene and forms a heterodimer RT with c-fos RL Proc. Natl. Acad. Sci. USA 88:4309-4312 (1991). XX // AC G000343 XX ID HS$M2DQB XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HLA-DQB XX DE MHC class II human leukocyte antigen DQbeta XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.6.5.3.2 XX BS -600 0 R01092; HS$M2DQB_01. BS -118 -78 R03695; HS$M2DQB_02; Binding factors: RFX , RFX1 BS , RFX2 , RFX2 , RFX3 , RFX3 , RFX1 BS . XX DR EMBL: X60276; HSHLADQC. DR EMBL: X60277; HSHLADQD. DR EMBL: X55423; HSHLADQE. DR EMBL: X55424; HSHLADQF. DR EMBL: K02405; HSMHDC3B. DR TRANSPATH: G000343. DR TRRD: 00207. DR LOCUSLINK: 3119. DR OMIM: 604305. DR REFSEQ: NM_002123. XX RN [1] RX MEDLINE; 92066479. RA Hasegawa S. L., Boss J. M. RT Two B cell factors bind the HLA-DRA X box region and recognize different RT subsets of HLA class II promoters RL Nucleic Acids Res. 19:6269-6276 (1991). RN [2] RX MEDLINE; 88040427. RA Miwa K., Strominger J. L. RT The HLA-DQbeta gene upstream region contains an immunoglobulin-like octamer RT motif that binds cell-type specific nuclear factors RL Nucleic Acids Res. 15:8057-8067 (1987). XX // AC G000344 XX ID HS$M2DRA XX DT 14.06.1995 (created); dbo. DT 25.02.2002 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HLA-DRA XX DE MHC class II human leukocyte antigen DRalpha XX SY HLA-DRA1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.6.5.3.2 XX BS -606 -557 R01086; HS$M2DRA_01. BS -198 -183 R02391; HS$M2DRA_09; Binding factors: XW,V . BS -145 -118 R01926; HS$M2DRA_07; Binding factors: NF-Zz , NF-Zc BS . BS -143 -129 R02390; HS$M2DRA_08; Binding factors: XW,V . BS -119 -78 R03104; HS$M2DRA_10; Binding factors: c-Fos , XBP-1 BS , X2BP , IFNEX , TIP . BS -115 -94 R01087; HS$M2DRA_02; Binding factors: NF-X2 , NF-Xc BS , RFX , XBP-1 , XX , NF-X , NF-X3 BS , RFX1 , RFX2 , RFX2 , RFX3 , RFX3 BS , RFX1 . BS -113 -82 R12102; HS$M2DRA_11; Binding factors: HTF . BS -88 -61 R01088; HS$M2DRA_03; Binding factors: RF-Y , YEBP BS . BS -85 -34 R01089; HS$M2DRA_04; Binding factors: (gamma)OBP . BS -52 -45 R01090; HS$M2DRA_05; Binding factors: oct-B2 . BS -52 -45 R01091; HS$M2DRA_06; Binding factors: oct-B2 . XX DR EMBL: X00274; HSHL07. DR EMBL: M23101; HSMHHLADR. DR TRANSPATH: G000344. DR TRANSCOMPEL: C00004. DR TRANSCOMPEL: C00068. DR TRANSCOMPEL: C00106. DR TRRD: 00077. DR LOCUSLINK: 3122. DR OMIM: 142860. DR REFSEQ: NM_019111. XX RN [1] RX MEDLINE; 20137507. RA Kokura K., Kishimoto T., Tamura T. RT Identity between rat htf and human xbp-1 genes: determination of gene RT structure, target sequence, and transcription promotion function for HTF. RL Gene 241:297-307 (2000). RN [2] RX MEDLINE; 96268751. RA Kishimoto T., Kokura K., Kumagai Y., Makino Y., Tamura T. RT HTF: A b-ZIP transcription factor that is closely related to the human RT XBP/TREB5 and is activated by hepatocellular carcinoma in rats. RL Biochem. Biophys. Res. Commun. 223:746-751 (1996). RN [3] RX MEDLINE; 93087559. RA Panek R. B., Moses H., Ting J. P.-Y., Benveniste E. N. RT Tumor necrosis factor alpha response elements in the HLA-DRA promoter: RT Identification of a tumor necrosis factor alpha-induced DNA-protein complex RT in astrocytes RL Proc. Natl. Acad. Sci. USA 89:11518- 11522 (1992). RN [4] RX MEDLINE; 92375076. RA Herrero Sanchez C., Reith W., Silacci P., Mach B. RT The DNA-binding defect observed in major histocompatibility complex class RT II regulatory mutants concerns only one member of a family of complexes RT binding to the X boxes of class II promoters RL Mol. Cell. Biol. 12:4076-4083 (1992). RN [5] RX MEDLINE; 92236613. RA Voliva C. F., Aronheim A., Walker M. D., Peterlin B. M. RT B-cell factor 1 is required for optimal expression of the DRA promoter in B RT cells RL Mol. Cell. Biol. 12:2383-2390 (1992). RN [6] RX MEDLINE; 91201893. RA Kouskoff V., Mantovani R. M., Candeias S. M., Dorn A., Staub A., RA Lisowska-Grospierre B., Griscelli C., Benoist C. O., Mathis D. J. RT NF-X, a transcription factor implicated in MHC class II gene regulation RL J. Immunol. 146:3197-3204 (1991). RN [7] RX MEDLINE; 91203859. RA Vilen B. J., Cogswell J. P., Ting J. P.-Y. RT Stereospecific alignment of the X and Y elements is required for major RT histocompatibility complex class II DRA promoter function RL Mol. Cell. Biol. 11:2406-2415 (1991). RN [8] RX MEDLINE; 91187669. RA Roy Ch., Lebleu B. RT DNA protein interactions at the interferon-responsive promoter elements: RT potential for a H-DNA conformation RL Nucleic Acids Res. 19:517 (1991). RN [9] RX MEDLINE; 91232904. RA Hasegawa S. L., Sloan J. H., Reith W., Mach B., Boss J. M. RT Regulatory factor-X binding to mutant HLA-DRA promoter sequences RL Nucleic Acids Res. 19:1243-1248 (1991). RN [10] RX MEDLINE; 92066479. RA Hasegawa S. L., Boss J. M. RT Two B cell factors bind the HLA-DRA X box region and recognize different RT subsets of HLA class II promoters RL Nucleic Acids Res. 19:6269-6276 (1991). RN [11] RX MEDLINE; 91156708. RA Zeleznik-Le N. J., Azizkhan J. C., Tin J. P.-Y. RT Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates RT expression of a human class II major histocompatibility complex gene and RT the herpes simplex virus thymidine kinase gene RL Proc. Natl. Acad. Sci. USA 88:1873-1877 (1991). RN [12] RX MEDLINE; 91239556. RA Ono S. J., Bazil V., Levi B.-Z., Ozato K., Strominger J. L. RT Transcription of a subset of human class II major histocompatibility RT complex genes is regulated by a nucleoprotein complex that contains c-fos RT or an antigenically related protein RL Proc. Natl. Acad. Sci. USA 88:4304-4308 (1991). RN [13] RX MEDLINE; 91239557. RA Ono S. J., Liou H.-C., Davidon R., Strominger J. L., Glimcher L. H. RT Human X-box-binding protein 1 is required for the transcription of a subset RT of human class II major histocompatibility gene and forms a heterodimer RT with c-fos RL Proc. Natl. Acad. Sci. USA 88:4309-4312 (1991). RN [14] RX MEDLINE; 91071581. RA Reith W., Herrero-Sanchez C., Kobr M., Silacci P., Berte Ch., Barras E., RA Fey S., Mach B. RT MHC class II regulatory factor RFX has a novel DNA-binding domain and a RT functionally independent dimerization domain RL Genes Dev. 4:1528-1540 (1990). RN [15] RX MEDLINE; 90136586. RA Tsang S. Y., Nakanishi M., Peterlin B. M. RT Mutational Analysis of the DRA Promoter: cis-Acting Sequences and RT trans-Acting Factors RL Mol. Cell. Biol. 10:711-719 (1990). RN [16] RX MEDLINE; 90245659. RA Roy C., Lebleu B. RT DNA-protein interactions at the interferon-responsive promoter: evidences RT for an involvement of phosphorylation RL Nucleic Acids Res. 18:2125-2131 (1990). RN [17] RX MEDLINE; 91017573. RA Cogswell J. P., Basta P. V., Ting J. P.-Y. RT X-box-binding proteins positively and negatively regulate transcription of RT the HLA-DRA gene through interaction with discrete upstream W and V elements RL Proc. Natl. Acad. Sci. USA 87:7703-7707 (1990). RN [18] RX MEDLINE; 90208323. RA Liou H.-C., Boothby M. R., Finn P. W., Davidson R., Nabavi N., Zeleznik-Le RA N. J., Ting J. P.-Y., Glimcher L. H. RT A new member of the leucine zipper class of proteins that binds to the HLA RT DRalpha promoter RL Science 247:1581-1584 (1990). RN [19] RX MEDLINE; 89181595. RA Sherman P. A., Basta P. V., Moore T. L., Brown A. M., Ting J. P.-Y. RT Class II Box Consensus Sequences in the HLA-DRalpha Gene: Transcriptional RT Function and Interaction with Nuclear Proteins RL Mol. Cell. Biol. 9:50-56 (1989). RN [20] RX MEDLINE; 89264585. RA Reith W., Barras E., Satola S., Kobr M., Reinhardt D., Sanchez C. H., Mach RA B. RT Cloning of the major histocompatibility complex class II promoter binding RT protein affected in a hereditary defect in class II gene regulation RL Proc. Natl. Acad. Sci. USA 86:4200-4204 (1989). RN [21] RX MEDLINE; 88253410. RA Reith W., Satola S., Herrero-Sanchez C., Amaldi I., Lisowska-Grospierre B., RA Griscelli C., Hadam M. R., Mach B. RT Congenital Immunodeficiency with a Regulatory Defect in MHC Class II Gene RT Expression Lacks a Specific HLA-DR Promoter Binding Protein, RF-X RL Cell 53:897-906 (1988). RN [22] RX MEDLINE; 89127213. RA Stimac E., Lyons S., Pious D. RT Transcription of HLA Class II Genes in the Absence of B-Cell-Specific RT Octamer-Binding Factor RL Mol. Cell. Biol. 8:3734-3739 (1988). XX // AC G000346 XX ID HS$MHC2IN XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD In XX DE MHC class II invariant chain XX SY DHLAG; MHC class II invariant chain. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 5q31-q33 XX BC 6.1.6.5.3.2 XX BS -107 -89 R03288; HS$MHC2IN_01. XX DR EMBL: M13555; HSIAIG1. DR TRANSCOMPEL: C00180. DR TRANSCOMPEL: C00190. DR TRRD: 00275. DR LOCUSLINK: 972. DR OMIM: 142790. DR REFSEQ: NM_004355. XX RN [1] RX MEDLINE; 91139631. RA Barr C. L., Saunders G. F. RT Interferon-gamma-inducible regulation of the human invariant chain gene RL J. Biol. Chem. 266:3475-3481 (1991). XX // AC G000347 XX ID HS$MLC XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MLC XX DE myosin light chain 1/3 locus XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.2.5.2 XX BS 210 238 R02418; HS$MLC_01; Binding factors: Myf-3 , Myf-4 BS , Myf-5 , Myf-6 , MyoD , MyoD . BS 269 294 R02419; HS$MLC_02; Binding factors: Myf-3 , Myf-4 BS , Myf-5 , MyoD , MyoD . XX DR TRANSPATH: G000347. DR TRRD: 00317. XX RN [1] RX MEDLINE; 91057100. RA Rosenthal N., Berglund E. B., Wentworth B. M., Donoghue M., Winter B., RA Bober E., Braun T., Arnold H.-H. RT A highly conserved enhancer downstream of the human MLC1/3 locus is a RT target for multiple myogenic determination factors RL Nucleic Acids Res. 18:6239 (1990). XX // AC G000348 XX ID HS$MYOGL XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Mb XX DE myoglobin XX SY PVALB. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 22q11.2-qter XX BC 6.1.3.10.1 XX BS -230 -206 R04162; HS$MYOGL_01. BS -174 -155 R09235; HS$MYOGL_02; Binding factors: MEF-2 , BS MEF-2DAB . XX DR EMBL: X00371; HSMG01. DR EMBL: M10090; HSMGI1. DR TRANSPATH: G000348. DR TRRD: 00042. DR LOCUSLINK: 4151. DR OMIM: 160000. DR REFSEQ: NM_005368. XX RN [1] RA Grayson J., Williams R. S., Yu Y.-T., Bassel-Duby R. RT Synegistic interactions between heterologous upstream activation elements RT and specific TATA sequences in a muscle-specific promoter RL Mol. Cell. Biol. 15:1870-1878 (1995). RN [2] RX MEDLINE; 93024448. RA Bassel-Duby R., Hernandez M. D., Gonzalez M. A., Krueger J. K., Williams R. RA S. RT A 40-Kilodalton protein binds specifically to an upstream sequence element RT essential for muscle-specific transcription of the human myoglobin promoter RL Mol. Cell. Biol. 12:5024-5032 (1992). XX // AC G000349 XX ID HS$NEU XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD neu XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17q11.2-q12 XX BS -321 -173 R02893; HS$NEU_01; Binding factors: c-Myc . XX DR TRANSPATH: G000349. DR LOCUSLINK: 2064. DR OMIM: 164870. DR REFSEQ: NM_004448. XX RN [1] RX MEDLINE; 91094850. RA Suen T.-C., Hung M.-C. RT c-myc reverses neu-induced transformed morphology by transcriptional RT repression RL Mol. Cell. Biol. 11:354-362 (1991). XX // AC G000350 XX ID HS$NPY XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD NPY XX DE neuropeptide Y XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 7pter-q22 XX BC 6.1.5.1 XX BS -102 0 R02026; HS$NPY_01; Binding factors: Sp1 . BS -91 0 R02027; HS$NPY_02; Binding factors: Sp1 . BS -85 -63 R02028; HS$NPY_03; Binding factors: AP-1 , BS CCAAT-binding factor . BS -61 -45 R02029; HS$NPY_04; Binding factors: Sp1 . XX DR EMBL: M14295; HSNPY1. DR TRANSPATH: G000350. DR LOCUSLINK: 4852. DR OMIM: 162640. DR REFSEQ: NM_000905. XX RN [1] RX MEDLINE; 90330629. RA Minth C. D., Dixon J. E. RT Expression of the Human Neuropeptide Y Gene RL J. Biol. Chem. 265:12933-12939 (1990). XX // AC G000351 XX ID HS$OAS1 XX DT 14.06.1995 (created); dbo. DT 29.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD OAS1 XX DE 2',5'-oligoadenylate synthetase 1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 12q24.2 XX BC 6.1.4.1 XX BS -113 -74 R00160; HS$OAS_01. BS -112 -73 R00161; HS$OAS_02; Binding factors: R1 . BS -112 -73 R00162; HS$OAS_03; Binding factors: R2 . BS -107 -83 R00163; HS$OAS_04; Binding factors: ICSBP . XX DR EMBL: M18099; HSOASE5G. DR TRANSPATH: G000351. DR BRENDA: 2.7.7.19; Human. DR TRRD: 00269. DR LOCUSLINK: 4938. DR OMIM: 164350. DR REFSEQ: NM_016816. XX RN [1] RX MEDLINE; 91072330. RA Wedrychowski A., Seong D., Paslidis N., Johnson E., Howard O. M. Z., Sims RA S., Talpaz M., Kantarjian H., Hester J., Turpin J., Lopez-Berestein G., RA Gutterman J., Freireich E. J., Deisseroth A. RT Characterization of nuclear proteins which bind to interferon-inducible RT transcriptional enhancers in hematopoietic cells RL J. Biol. Chem. 65:21433-21440 (1990). RN [2] RX MEDLINE; 91056171. RA Seong D. C., Sims S., Johnson E., Howard O. M. Z., Reiter B., Hester J., RA Talpaz M., Kantarjian H., Deisseroth A. RT A phosphatase activity present in peripheral blood myeloid cells of chromic RT myelogenous leukemia patients but not normal individuals alters nuclear RT protein binding to transcriptional enhancers of interferon-inducible genes RL J. Clin. Invest. 86:1664-1670 (1990). RN [3] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [4] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [5] RX MEDLINE; 89160323. RA Cohen B., Vaiman D., Chebath J. RT Enhancer functions and in vitro protein binding of native and mutated RT interferon-responsive sequences RL Nucleic Acids Res. 17:1679-1695 (1989). RN [6] RX MEDLINE; 88283644. RA Rutherford M. N., Hannigan G. E., Williams B. R. G. RT Interferon-induced binding of nuclear factors to promoter elements of the RT 2-5A synthetase gene RL EMBO J. 7:751-759 (1988). XX // AC G000352 XX ID HS$ODC XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ODC XX DE ornithine decarboxylase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 2p25 XX BC 6.1.4.3.1 XX BS -491 -474 R04462; HS$ODC_02; Binding factors: c-Myc , Max1 BS . BS 277 291 R04415; HS$ODC_01; Binding factors: AP-2alphaA , c-Myc BS , Max1 , AP-2alphaB . XX DR EMBL: M81740; HSODC1A. DR EMBL: X16277; HSODCG. DR EMBL: M31061; HSSODA. DR EMBL: S71124; S71124. DR TRANSPATH: G000352. DR BRENDA: 4.1.1.17; Human. DR TRRD: 00209. DR LOCUSLINK: 4953. DR OMIM: 165640. DR REFSEQ: NM_002539. XX RN [1] RX MEDLINE; 95246744. RA Gaubatz S., Imhof A., Dosch R., Werner O., Mitchell P., Buettner R., Eilers RA M. RT Transcriptional avtivation by Myc is under negative control by the RT transcription factor AP-2 RL EMBO J. 14:1508-1519 (1995). RN [2] RX MEDLINE; 93361535. RA Bello-Fernandez C., Packham G., Cleveland J. L. RT The ornithine decarboxylase gene is a transcriptional target of c-Myc RL Proc. Natl. Acad. Sci. USA 90:7804-7808 (1993). RN [3] RX MEDLINE; 94086544. RA Pena A., Reddy C. D., Wu S., Hickok N. J., Reddy E. P., Yumet G., Soprano RA D. R., Soprano K. J. RT Regulation of human ornithine decarboxylase expression by the c-Myc Max RT protein complex RL J. Biol. Chem. 268:27277-27285 (1993). XX // AC G000353 XX ID HS$BGLAP XX DT 14.06.1995 (created); dbo. DT 21.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD BGLAP XX DE bone gamma-carboxyglutamate protein XX SY Gla protein; osteocalcin; Bone gamma-carboxyglutamic acid protein. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1q25-q31 XX BC 6.1.5.12 XX BS -521 -475 R10026; HS$OC_03; Binding factors: VDR . BS -510 -489 R01187; HS$OC_01; Binding factors: RAR-alpha1 , VDR BS , VDR , RXR-beta , TRAP . BS -35 -14 R03558; HS$OC_02; Binding factors: GR , TBP , BS GR . XX DR EMBL: AB004306; AB004306. DR EMBL: E13404; E13404. DR EMBL: X04143; HSBGPG. DR TRANSPATH: G000353. DR PATHODB: MR000031. DR TRRD: 00364. DR LOCUSLINK: 632. DR OMIM: 112260. DR REFSEQ: NM_000711. XX RN [1] RX MEDLINE; 98049529. RA Meyer T., Carlstedt-Duke J., Starr D. B. RT A weak TATA box is a prerequisite for glucocorticoid-dependent repression RT of the osteocalcin gene RL J. Biol. Chem. 272:30709-30714 (1997). RN [2] RX MEDLINE; 93280105. RA Rosen E. D., Beninghof E. G., Koenig R. J. RT Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and RT retinoid X receptors RL J. Biol. Chem. 268:11534-11541 (1993). RN [3] RX MEDLINE; 93173203. RA Carlberg C., Bendik I., Wyss A., Meier E., Sturzenbecker L. J., Grippo J. RA F., Hunziker W. RT Two nuclear signalling pathways for vitamin D RL Nature 361:657-660 (1993). RN [4] RX MEDLINE; 91246209. RA Stroemstedt P.-E., Poellinger L., Gustafsson J.-A., Carlstedt-Duke J. RT The glucocorticoid receptor binds to a sequence overlapping the TATA box of RT the human osteocalcin promoter: A potential mechanism for negative RT regulation RL Mol. Cell. Biol. 11:3379-3383 (1991). RN [5] RX MEDLINE; 90242395. RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado J., Pike J. W., Evans R. RA M. RT Jun-Fos and receptors for vitamins A and D recognize a common response RT element in the human osteocalcin gene RL Cell 61:497-504 (1990). XX // AC G000354 XX ID HS$OV XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ovalbumin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.3.1 XX // AC G000355 XX ID HS$OT XX DT 21.05.1996 (created); ake. DT 27.05.2002 (updated); elf. CO Copyright (C), Biobase GmbH. XX SD OT XX DE oxytocin XX SY OXT; OT-NPI. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 20p13 XX BC 6.1.5.1 XX DR TRANSPATH: G000355. DR TRRD: 00048. DR LOCUSLINK: 5020. DR OMIM: 167050. DR REFSEQ: NM_000915. XX // AC G000356 XX ID HS$NFKB1 XX DT 21.05.1996 (created); ake. DT 28.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD NFKB1 XX DE nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 XX SY KBF1; NF-kappaB (p50); p50; p105; NF-kappaB1 (p105). XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 4q24 XX BC 6.1.2.2.4 XX FA T00593; NF-kappaB1. FA T01925; NF-kappaB1 precursor. XX DR TRANSPATH: G000356. DR TRRD: 00117. DR LOCUSLINK: 4790. DR OMIM: 164011. DR REFSEQ: NM_003998. XX // AC G000357 XX ID HS$PAI1 XX DT 21.05.1996 (created); ake. DT 17.07.2001 (updated); dkl. CO Copyright (C), Biobase GmbH. XX SD PAI-1 XX DE plasminogen activator inhibitor type 1 XX SY PAI1; PLANH1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 7q21.3-q22 XX BC 6.1.6.3 XX BS -730 -722 R10058; HS$PAI1_03. BS -688 -660 R09967; HS$PAI1_02; Binding factors: SMAD-3 , SMAD-4 BS . BS -586 -551 R10079; HS$PAI1_05; Binding factors: TFE3 , SMAD-3 BS , SMAD-4 . BS -583 -528 R10078; HS$PAI1_04; Binding factors: TFE3 , SMAD-3 BS , SMAD-4 . BS -86 -60 R09714; HS$PAI1_01; Binding factors: HLTF , HLTF BS (Met123) . XX DR EMBL: M33136; HSPAI1. DR EMBL: X13323; HSPAI11. DR TRANSPATH: G000357. DR TRANSCOMPEL: C00198. DR TRANSCOMPEL: C00199. DR TRRD: 00050. DR LOCUSLINK: 5054. DR OMIM: 173360. DR REFSEQ: NM_000602. XX RN [1] RX MEDLINE; 99194790. RA Stroschein S. L., Wang W., Luo K. RT Cooperative binding of Smad proteins to two adjacent DNA elements in the RT plasminogen activator inhibitor-1 promoter mediates transforming growth RT factor beta-induced smad-dependent transcriptional activation. RL J. Biol. Chem. 274:9431-9441 (1999). RN [2] RX MEDLINE; 20027512. RA Hua X., Miller Z. A., Wu G., Shi Y., Lodish H. F. RT Specificity in transforming growth factor beta-induced transcription of the RT plasminogen activator inhibitor-1 gene: interactions of promoter DNA, RT transcription factor muE3, and Smad proteins. RL Proc. Natl. Acad. Sci. USA 96:13130-13135 (1999). RN [3] RX MEDLINE; 98270875. RA Dennler S., Itoh S., Vivien D., ten Dijke P., Huet S., Gauthier J. M. RT Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements RT in the promoter of human plasminogen activator inhibitor-type 1 gene. RL EMBO J. 17:3091-3100 (1998). RN [4] RX MEDLINE; 98438454. RA Hua X., Liu X., Ansari D. O., Lodish H. F. RT Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced RT transcription of the plasminogen activator inhibitor-1 gene. RL Genes Dev. 12:3084-3095 (1998). RN [5] RX MEDLINE; 96268471. RA Ding H., Descheemaeker K., Marynen P., Nelles L., Carvalho T., RA Carmo-Fonseca M., Collen D., Belayew A. RT Characterization of a helicase-like transcription factor involved in the RT expression of the human plasminogen activator inhibitor-1 gene RL DNA Cell Biol. 15:429-442 (1996). XX // AC G000358 XX ID HS$PAI XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD PAI-2 XX DE plasminogen activator inhibitor type 2 XX SY PAI; PAI2; FCER1A; PLANH2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.6.3 XX BS -217 -207 R03349; HS$PAI_01. BS -194 -178 R03350; HS$PAI_02. BS -141 -129 R03351; HS$PAI_03. BS -110 -91 R03352; HS$PAI_04; Binding factors: AP-1 . BS -80 -72 R03353; HS$PAI_05. BS -67 -42 R03354; HS$PAI_06; Binding factors: Sp1 . BS -37 -20 R03355; HS$PAI_07. XX DR EMBL: M22469; HSPAI2AA. DR TRANSPATH: G000358. XX RN [1] RX MEDLINE; 91319546. RA Cousin E., Medcalf R. L., Bergonzelli G. E., Kruithof E. K. O. RT Regulatory elements involved in constitutive and phorbol ester-inducible RT expression of the plasminogen activator inhibitor type 2 gene promoter RL Nucleic Acids Res. 19:3881-3886 (1991). XX // AC G000359 XX ID HS$PBGD XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD PBGD XX DE porphobilinogen deaminase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11q23.2-qter XX BC 6.1.4.4/ XX BS -191 -173 R01247; HS$PBGD_01; Binding factors: GATA-1 , GATA-1 BS . BS -168 -145 R01249; HS$PBGD_03; Binding factors: AP-1 , AP-1 BS , NF-E2 , NF-E2 , MafK , NF-E2 p45 . BS -168 -109 R01250; HS$PBGD_04; Binding factors: NF-E2 , NF-E2 BS , NF-U1 . BS -168 -109 R01251; HS$PBGD_05; Binding factors: CAC-binding protein BS , NF-E2 , NF-E2 . BS -109 -90 R01252; HS$PBGD_06; Binding factors: CAC-binding protein BS . BS -82 -61 R01253; HS$PBGD_07; Binding factors: GATA-1 , GATA-1 BS . BS -1 14 R02920; HS$PBGD_10. BS 36 55 R01254; HS$PBGD_08; Binding factors: GATA-1 , GATA-1 BS . BS 36 55 R01255; HS$PBGD_09; Binding factors: CAC-binding protein BS . XX DR EMBL: M18800; HSPBGD2. DR EMBL: M95623; HSPBGDA. DR TRANSPATH: G000359. DR BRENDA: 4.3.1.8; Human. DR TRRD: 00380. DR LOCUSLINK: 3145. DR OMIM: 176000. DR REFSEQ: NM_000190. XX RN [1] RX MEDLINE; 95221427. RA Igarashi K., Itoh K., Motohashi H., Hayashi N., Matuzaki Y., Nakauchi H., RA Nishizawa M., Yamamoto M. RT Activity and expression of murine small Maf family protein MafK RL J. Biol. Chem. 270:7615-7624 (1995). RN [2] RX MEDLINE; 93226042. RA Andrews N. C., Erdjument-Bromage H., Davidson M. B., Tempst P., Orkin S. H. RT Erythroid transcription factor NF-E2 is a haematopoietic-specific RT basic-leucine zipper protein RL Nature 362:722-728 (1993). RN [3] RX MEDLINE; 93215655. RA Eleouet J.-F., Romeo P.-H. RT CCACC-binding or simian-virus-40-protein-1-binding proteins cooperate with RT human GATA-1 to direct erythroid-specific transcription and to mediate 5' RT hypersensitive site 2 sensitivity of a TATA-less promoter RL Eur. J. Biochem. 212:763-770 (1993). RN [4] RX MEDLINE; 91093039. RA Mignotte V., Navarro S., Eleouet F.-F., Zon L. I., Romeo P.-H. RT The extinction of erythroid genes after tetradecanoylphorbol acetate RT treatment of erythroleukemic cells correlates with down-regulation of the RT tissue-specific factors NF-E1 and NF-E2 RL J. Biol. Chem. 265:22090-22092 (1990). RN [5] RX MEDLINE; 90206049. RA Romeo P.-H., Prandini M.-H., Joulin V., Mignotte V., Prenant M., RA Vainchenker W., Marguerie G., Uzan G. RT Megakaryocytic and erythrocytic lineages share specific transcription RT factors RL Nature 344:447-449 (1990). RN [6] RX MEDLINE; 90206049. RA Romeo P.-H., Prandini M.-H., Joulin V., Mignotte V., Prenant M., RA Vainchenker W., Marguerie G., Uzan G. RT Megakaryocytic and erythrocytic lineages share specific transcription RT factors RL Nature 344:447-449 (1990). RN [7] RX MEDLINE; 91045061. RA Ney P. A., Sorrentino B. P., Lowrey Ch. H., Nienhuis A. W. RT Inducibility of the HS II enhancer depends on binding of an erythroid RT specific nuclear protein RL Nucleic Acids Res. 18:6011-6017 (1990). RN [8] RX MEDLINE; 91067432. RA Beaupain D., Eleouet J. F., Romeo P. H. RT Initiation of transcription of the erythroid promoter of the RT porphobilinogen deaminase gene is regulated by a cis-acting sequence around RT the cap site RL Nucleic Acids Res. 18:6509-6515 (1990). RN [9] RX MEDLINE; 90287181. RA Frampton J., Walker M., Plumb M., Harrison P. R. RT Synergy between the NF-E1 erythroid-specific transcription factor and the RT CACCC factor in the erythroid-specific promoter of the human RT porphobilinogen deaminase gene RL Mol. Cell. Biol. 10:3838-3842 (1990). RN [10] RX MEDLINE; 89098433. RA Plumb M., Frampton J., Wainwright H., Walker M., MacLeod K., Goodwin G., RA Harrison P. RT GATAAG; a cis-control region binding an erythroid-specific nuclear factor RT with a role in globin and non-globin gene expression RL Nucleic Acids Res. 17:73-92 (1989). RN [11] RX MEDLINE; 89098393. RA Mignotte V., Wall L., deBoer E., Grosveld F., Romeo P.-H. RT Two tissue-specific factors bind to the erythroid promoter of the human RT porphobilinogen deaminase gene RL Nucleic Acids Res. 17:37-54 (1989). RN [12] RX MEDLINE; 89367286. RA Mignotte V., Eleouet J. F., Raich N., Romeo P.-H. RT Cis- and trans-acting elements involved in the regulation of the erythroid RT promoter of the human porphobilinogen deaminase gene RL Proc. Natl. Acad. Sci. USA 86:6548-6552 (1989). XX // AC G000360 XX ID HS$PDGFB XX DT 14.06.1995 (created); dbo. DT 29.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD PDGFB XX DE platelet-derived growth factor chain B XX SY SIS; PDGF-2; SIS/PDGF-B. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 22q12.3-q13.1 XX BS -228 -219 R04895; HS$PDGF2_03. BS -103 -60 R01197; HS$PDGF2_01. BS -97 -88 R04896; HS$PDGF2_04. BS -68 -27 R04897; HS$PDGF2_05; Binding factors: Sp1 . BS -5 18 R04513; HS$PDGF2_02; Binding factors: ZNF174 . XX DR EMBL: M19719; HSPDGF01. DR EMBL: X03493; HSSISG5. DR EMBL: Y00389; HSSISG5B. DR TRANSPATH: G000360. DR LOCUSLINK: 5155. DR OMIM: 190040. DR REFSEQ: NM_033016. XX RN [1] RX MEDLINE; 95403401. RA Williams A. J., Khachigian L. M., Shows T., Collins T. RT Isolation and characterization of a novel zinc-finger protein with RT transcriptional repressor activity RL J. Biol. Chem. 270:22143-22152 (1995). RN [2] RX MEDLINE; 95050666. RA Jin H.-M., Robinson D. F., Liang Y., Fahl W. E. RT SIS/PDGF-B promoter isolation and characterization of regulatory elements RT necessary for basal expression of the SIS/PDGF-B gene in U2-OS osteosarcoma RT cells RL J. Biol. Chem. 269:28648-28654 (1994). RN [3] RX MEDLINE; 89219031. RA Pech M., Rao C. D., Robbins K. C., Aaronson S. A. RT Functional Identification of Regulatory Elements within the Promoter Region RT of Platelet-Derived Growth Factor 2 RL Mol. Cell. Biol. 9:396-405 (1989). XX // AC G000361 XX ID HS$PGAMM XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD PGAM-M XX DE phosphoglycerate mutase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 7 XX BC 6.1.4 XX BS -162 -153 R04212; HS$PGAMM_01; Binding factors: MEF-2 , MEF-2 BS , MEF-2 (516 AA) . XX DR EMBL: M55673; HSPGAMM1. DR EMBL: J05073; HSPGAMMG. DR TRANSPATH: G000361. DR BRENDA: 5.4.2.1; Human. DR LOCUSLINK: 112925. XX RN [1] RX MEDLINE; 93024380. RA Nakatsuji Y., Hidaka K., Tsujino S., Yamamoto Y., Mukai T., Yanagihara T., RA Kishimoto T., Sakoda S. RT A single MEF-2 site is a major positive regulatory element required for RT transcription of the muscle-specific subunit of the human phosphoglycerate RT mutase gene in skeletal and cardiac muscle cells RL Mol. Cell. Biol. 12:4384-4390 (1992). XX // AC G000362 XX ID HS$PGK XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD PGK-1 XX DE X-linked phosphoglycerate kinase XX SY PGK1; PGKA. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH X XX BC 6.1.4 XX BS -255 -235 R03208; HS$PGK_01. BS -223 -187 R03209; HS$PGK_02. BS -161 -123 R03210; HS$PGK_03; Binding factors: ENKTF-1 . BS -114 -84 R03211; HS$PGK_04. BS -63 -33 R03212; HS$PGK_05. XX DR EMBL: M60581; HSPGK1A. DR TRANSPATH: G000362. DR BRENDA: 2.7.2.3; Human. DR LOCUSLINK: 112575. XX RN [1] RX MEDLINE; 91257576. RA Pfeifer G. P., Riggs A. D. RT Chromatin differences between active and inactive X chromosomes revealed by RT genomic footprinting of permeabilized cells using DNase I and RT ligation-mediated PCR RL Genes Dev. 5:1102-1113 (1991). XX // AC G000363 XX ID HS$PIM1 XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Pim-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21 XX BC 6.1.5.16 XX DR TRRD: 00193. DR LOCUSLINK: 5292. DR OMIM: 164960. DR REFSEQ: NM_002648. XX // AC G000364 XX ID HS$HPL3 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD PL3 XX DE placental lactogen hPL3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.5.3 XX BS 116 134 R02030; HS$HPL3_01; Binding factors: TEF-1 . XX DR TRANSPATH: G000364. XX RN [1] RX MEDLINE; 90330630. RA Walker W. H., Fitzpatrick S. L., Saunders G. F. RT Human Placental Lactogen Transcriptional Enhancer RL J. Biol. Chem. 265:12940-12948 (1990). XX // AC G000367 XX ID HS$PR264 XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD PR264/SC35 XX DE splicing factor PR264/SC35 XX SY SC-35; PR264; SC35. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17 XX BS -937 -915 R04174; HS$PR264_01; Binding factors: c-Myb . BS -897 -872 R04175; HS$PR264_02; Binding factors: c-Myb . BS -834 -811 R04176; HS$PR264_03; Binding factors: c-Myb . BS -366 -331 R04177; HS$PR264_04; Binding factors: c-Myb . BS -246 -230 R04178; HS$PR264_05; Binding factors: c-Myb . BS -226 -195 R04179; HS$PR264_06; Binding factors: c-Myb . BS -141 -98 R04180; HS$PR264_07; Binding factors: c-Myb . BS -36 -13 R04181; HS$PR264_08; Binding factors: c-Myb . BS -6 16 R04182; HS$PR264_09; Binding factors: c-Myb . BS 81 101 R04183; HS$PR264_10; Binding factors: c-Myb . BS 130 147 R04184; HS$PR264_11; Binding factors: c-Myb . XX DR EMBL: L03693; HSPR264X. DR TRANSPATH: G000367. DR LOCUSLINK: 6427. DR OMIM: 600813. DR REFSEQ: NM_003016. XX RN [1] RX MEDLINE; 93101590. RA Sureau A., Soret J., Vellard M., Crochet J., Perbal B. RT The PR264/c-myb connection: Expression of a splicing factor modulated by a RT nuclear protooncogene RL Proc. Natl. Acad. Sci. USA 89:11683-11687 (1992). XX // AC G000368 XX ID HS$PL XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD prl XX DE prolactin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p22.2-p21.3 XX BC 6.1.5.3.2 XX BS -2025 -1975 R02783; HS$PL_01; Binding factors: POU1F1a . BS -1882 -1861 R02784; HS$PL_02; Binding factors: POU1F1a . BS -1827 -1808 R02785; HS$PL_03. BS -1695 -1669 R02786; HS$PL_04; Binding factors: POU1F1a . BS -1658 -1639 R02787; HS$PL_05; Binding factors: POU1F1a . BS -1601 -1583 R02788; HS$PL_06; Binding factors: AP-1 , AP-1 BS . BS -1397 -1372 R02789; HS$PL_07; Binding factors: POU1F1a . BS -1339 -1310 R02790; HS$PL_08; Binding factors: POU1F1a . BS -1303 -1260 R02791; HS$PL_09; Binding factors: POU1F1a . BS -1230 -1205 R02792; HS$PL_10; Binding factors: POU1F1a . BS -164 -115 R03481; HS$PL_11; Binding factors: POU1F1a . BS -114 -85 R03482; HS$PL_12. BS -64 -35 R03483; HS$PL_13; Binding factors: POU1F1a , POU1F1b BS , POU1F1c . XX DR EMBL: X00368; HSPROL1. DR TRANSPATH: G000368. DR TRRD: 00211. DR LOCUSLINK: 5617. DR OMIM: 176760. DR REFSEQ: NM_000948. XX RN [1] RX MEDLINE; 98289382. RA Pernasetti F., Milner R. D. G., Al Ashwal A. A. Z., de Zegher F., Chavez V. RA M., Muller M., Martial J. A. RT Pro239Ser: A novel recessive mutation of the Pit-1 gene in seven middle RT eastern children with growth hormone, prolactin, and thyrotropin deficiency RL J. Clin. Endocrinol. Metab. 83:2079-2083 (1998). RN [2] RX MEDLINE; 92289691. RA Theill L. E., Hattori K., Lazzaro D., Castrillo J.-L., Karin M. RT Differential splicing of the GHF1 primary transcript gives rise to two RT functionally distinct homeodomain proteins RL EMBO J. 11:2261-2269 (1992). RN [3] RX MEDLINE; 92011543. RA Peers B., Monget P., Nalda M. A., Voz M. L., Berwaer M., Belayew A., RA Martial J. A. RT Transcriptional induction of the human prolactin gene by cAMP requires two RT cis-acting elements and at least the pituitary-specific factor Pit-1 RL J. Biol. Chem. 266:18127-18134 (1991). RN [4] RX MEDLINE; 90355985. RA Peers B., Voz M. L., Monget Ph., Mathy-Hartert M., Berwaer M., Belayew A., RA Martial J. A. RT Regulatory elements controlling pituitary-specific expression of the human RT prolactin gene RL Mol. Cell. Biol. 10:4690-4700 (1990). XX // AC G000369 XX ID HS$PK XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD ENK XX DE proenkephalin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 8q23-q24 XX BC 6.1.5.1 XX BS -110 -88 R01256; HS$PK_01; Binding factors: CREB , ENKTF-1 BS . BS -105 -76 R01257; HS$PK_02. BS -99 -80 R01258; HS$PK_03; Binding factors: AP-1 , c-Fos BS , c-Jun , CRE-BP1 , CREB , ATF3 , BS CREBbeta . BS -94 -75 R01259; HS$PK_04; Binding factors: AP-4 . BS -85 -65 R01261; HS$PK_05; Binding factors: AP-2alphaA , BS AP-2alphaB . XX DR EMBL: K00488; HSENKPH1. DR TRANSPATH: G000369. DR LOCUSLINK: 5179. DR OMIM: 131330. DR REFSEQ: NM_006211. XX RN [1] RX MEDLINE; 96070900. RA Spiro C., Bazett-Jones D. P., Wu X., McMurray C. T. RT DNA structure determines protein binding and transcriptional efficiency of RT the proenkephalin cAMP-responsive enhancer RL J. Biol. Chem. 270:27702-27710 (1995). RN [2] RX MEDLINE; 92371441. RA Nichols M., Weih F., Schmid W., DeVack C., Kowenz-Leutz E., Luckow B., RA Boshart M., Schuetz G. RT Phosphorylation of CREB affects its binding to high and low affinity sites: RT implications for cAMP induced gene transcription RL EMBO J. 11:3337-3346 (1992). RN [3] RX MEDLINE; 91252218. RA Chu H.-M., Fischer W. H., Osborne T. F., Comb M. J. RT NF-I proteins from brain interact with the proenkephalin cAMP inducible RT enhancer RL Nucleic Acids Res. 19:2721 (1991). RN [4] RX MEDLINE; 91219443. RA Hai T., Curran T. RT Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB RT alters DNA binding specificity RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991). RN [5] RX MEDLINE; 90326521. RA Comb M., Goodman H. M. RT CpG methylation inhibits proenkephalin gene expression and binding of the RT transcription factor AP-2 RL Nucleic Acids Res. 18:3975-3982 (1990). RN [6] RX MEDLINE; 90084525. RA Sonnenberg J. L., Rauscher III F. J., Morgan J. I., Curran T. RT Regulation of proenkephalin by Fos and Jun RL Science 246:1622-1625 (1989). RN [7] RX MEDLINE; 89091127. RA Comb M., Mermod N., Hyman S. E., Pearlberg J., Ross M. E., Goodman H. M. RT Proteins bound adjacent DNA elements act synergistically to regulate human RT proenkephalin cAMP inducible transcription RL EMBO J. 7:3793-3805 (1988). RN [8] RX MEDLINE; 88261270. RA Andrisani O. M., Pot D. A., Zhu Z., Dixon J. E. RT Three Sequence-Specific DNA-Protein Complexes Are Formed with the Same RT Promoter Element Essential for Expression of the Rat Somatostatin Gene RL Mol. Cell. Biol. 8:1947-1956 (1988). RN [9] RX MEDLINE; 89039849. RA Hyman S. E., Comb M., Lin Y.-S., Pearlberg J., Green M. R., Goodman H. M. RT A Common trans-Acting Factor Is Involved in Transcriptional Regulation of RT Neurotransmitter Genes by Cyclic AMP RL Mol. Cell. Biol. 8:4225-4233 (1988). RN [10] RX MEDLINE; 88189275. RA Mermod N., Williams T. J., Tjian R. RT Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late RT transcription in vitro RL Nature 332:557-561 (1988). XX // AC G000370 XX ID HS$PCNA XX DT 14.06.1995 (created); dbo. DT 27.11.2001 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD PCNA p120 XX DE proliferating cell nucleolar antigen p120 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 20pter-p12 XX BC 6.1.7.1 XX BS -1430 -1327 R03067; HS$PCNA_02. BS -428 -407 R03868; HS$PCNA_01; Binding factors: Sp1 . BS -238 -199 R11722; HS$PCNA_05; Binding factors: p53 . BS -60 -40 R11434; HS$PCNA_04; Binding factors: RFX1 . BS 579 590 R08847; HS$PCNA_03; Binding factors: E2F-4 . XX DR EMBL: M33132; HSP12AA. DR EMBL: J05614; HSPCNAPR. DR TRANSPATH: G000370. DR TRRD: 00368. DR LOCUSLINK: 5111. DR OMIM: 176740. DR REFSEQ: NM_002592. XX RN [1] RX MEDLINE; 99419071. RA Tommasi S., Pfeifer G. P. RT In vivo structure of two divergent promoters at the human PCNA locus. RT Synthesis of antisense RNA and S phase-dependent binding of E2F complexes RT in intron 1 RL J. Biol. Chem. 274:27829-27838 (1999). RN [2] RX MEDLINE; 99269075. RA Liu M., Lee B. H., Mathews M. B. RT Involvement of RFX1 protein in the regulation of the human proliferating RT cell nuclear antigen promoter RL J. Biol. Chem. 274:15433-15439 (1999). RN [3] RA Morris G. F., Bischoff J. R., Mathews M. B. RT Transcriptional activation of the human proliferating-cell nuclear antigen RT promoter by p53 RL Proc. Natl. Acad. Sci. USA 93:895-899 (1996). RN [4] RA Shivakumar C. V., Brown D. R., Deb S., Deb S. P. RT Wild-type human p53 transactivates the human proliferating cell nuclear RT antigen promoter RL Mol. Cell. Biol. 15:6785-6793 (1995). RN [5] RX MEDLINE; 91128382. RA Zhang W.-W., Farres J., Busch H. RT Purification of a novel 55 kDa HeLa cell nuclear DNA-binding protein RL Biochem. Biophys. Res. Commun. 174:542-548 (1991). RN [6] RX MEDLINE; 92093618. RA Haidar M. A., Henning D., Busch H. RT Sp1 is essential and its position is important for p120 gene transcription: RT a 35 bp juxtaposed positive regulatory element enhances transcription 2.5 RT fold RL Nucleic Acids Res. 19:6559-6563 (1991). XX // AC G000372 XX ID HS$PTHRO XX DT 14.06.1995 (created); dbo. DT 21.05.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Pt XX DE prothrombin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.4.7.1 XX BS -941 -920 R04123; HS$PTHRO_02; Binding factors: HNF-1 . BS -911 -867 R04122; HS$PTHRO_01; Binding factors: HNF-1 . XX DR EMBL: M65141; HSPROTHRO. DR TRANSPATH: G000372. DR TRRD: 00190. XX RN [1] RX MEDLINE; 92011662. RA Chow B. K.-C., Ting V., Tufaro F., MacGillivray R. T. A. RT Characterization of a novel liver-specific enhancer in the human RT prothrombin gene RL J. Biol. Chem. 266:18927-18933 (1991). XX // AC G000373 XX ID HS$PS2 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD PS2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.7.2 XX BS empty empty R03575; HS$PS2_01. XX RN [1] RX MEDLINE; 91168872. RA Metzger D. A., Curtis S., Korach K. S. RT Diethylstilbestrol metabolites and analogs: differential ligand effects on RT estrogen receptor interactions with nuclear matrix sites RL Endocrinology 128:1785-1791 (1991). XX // AC G000374 XX ID HS$PTH XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD PTH XX DE parathyroid hormone XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.3-p15.1 XX BC 6.1.5.4 XX BS -4194 -4180 R11433; HS$PTH_04; Binding factors: Ref-1 . BS -3354 -3337 R11432; HS$PTH_03; Binding factors: Ref-1 . BS -126 -101 R10019; HS$PTH_02; Binding factors: VDR . BS -115 -96 R11695; HS$PTH_05; Binding factors: factor C complex . BS -98 -69 R03738; HS$PTH_01; Binding factors: CREB , CREB BS . XX DR EMBL: AF346654; AF346654. DR EMBL: J00300; HSPTH1. DR TRANSPATH: G000374. DR LOCUSLINK: 5741. DR OMIM: 168450. DR REFSEQ: NM_000315. XX RN [1] RX MEDLINE; 99240483. RA Darwish H. M., DeLuca H. F. RT Identification of a transcription factor that binds to the promoter region RT of the human parathyroid hormone gene RL Arch. Biochem. Biophys. 365:123-130 (1999). RN [2] RX MEDLINE; 95050551. RA Okazaki T., Chung U., Nishishita T., Ebisu S., Usuda S., Mishiro S., RA Xanthoudakis S., Igarashi T., Ogata E. RT A redox factor protein, ref1, is involved in negative gene regulation by RT extracellular calcium RL J. Biol. Chem. 269:27855-27862 (1994). RN [3] RX MEDLINE; 92390396. RA Demay MB, Kiernan MS, DeLuca HF, Kronenberg HM. RT Sequences in the human parathyroid hormone gene that bind the RT 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in RT response to 1,25-dihydroxyvitamin D3 RL Proc. Natl. Acad. Sci. USA 89:8097-8101 (1992). RN [4] RX MEDLINE; 92210725. RA Okazaki T., Ando K., Igarashi T., Ogata E., Fujita T. RT Conserved mechanism of negative gene regulation by extracellular calcium. RT Parathyroid hormone gene versus atrial natriuretic polypeptide gene RL J. Clin. Invest. 89:1268-1273 (1992). RN [5] RX MEDLINE; 92042102. RA Okazaki T., Zajac J. D., Igarashi T., Ogata E., Kronenberg H. M. RT Negative regulatory elements in the human parathyroid hormone gene RL J. Biol. Chem. 266:21903-21910 (1991). RN [6] RX MEDLINE; 91016901. RA Rupp E., Mayer H., Wingender E. RT The promoter of the human parathyroid hormone gene contains a functional RT cyclic AMP-response element RL Nucleic Acids Res. 18:5677-5683 (1990). XX // AC G000376 XX ID HS$RARB XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD RAR-beta XX DE retinoic acid receptor beta XX SY HAP; NR1B2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 3p24 XX BC 6.1.2.2.4 XX BS -59 -33 R01321; HS$RARB_01; Binding factors: CF1 , RAR-alpha1 BS , RAR-gamma , RAR-beta , v-ErbA , RAR-beta2 BS , RAR-gamma , RXR-alpha , RXR-beta , BS RXR-gamma , RXR-alpha , CAR . XX FA T01326; RAR-beta2. XX DR EMBL: X56849; HSRARBP. DR EMBL: X51650; HSRARBPE. DR TRANSPATH: G000376. DR TRANSCOMPEL: C00077. DR TRRD: 00212. DR LOCUSLINK: 5915. DR OMIM: 180220. DR REFSEQ: NM_016152. XX RN [1] RX MEDLINE; 94158827. RA Baes M., Gulick T., Choi H. S., Martinoli M. G., Simha D., Moore D. D. RT A new orphan member of the nuclear hormone receptor superfamily that RT interacts with a subset of retinioc acid response elements RL Mol. Cell. Biol. 14:1544- 1551 (1994). RN [2] RX MEDLINE; 94313985. RA Barettino D., Vivanco Ruiz M. d. M., Stunnenberg H. G. RT Characterization of the ligand-dependent transactivation domain of thyroid RT hormone receptor RL EMBO J. 13:3039-3049 (1994). RN [3] RX MEDLINE; 93321870. RA Kurokawa R., Yu V. C., Naeaer A., Kyakumoto S., Han Z., Silverman S., RA Rosenfeld M. G., Glass C. K. RT Differential orientations of the DNA-binding domain and carboxy-terminal RT dimerization interface regulate binding site selection by nuclear receptor RT heterodimers RL Genes Dev. 7:1423-1435 (1993). RN [4] RX MEDLINE; 93321869. RA Perlmann T., Rangarajan P. N., Umesono K., Evans R. M. RT Determinants for selective RAR and TR recognition of direct repeat HREs RL Genes Dev. 7:1411-1422 (1993). RN [5] RX MEDLINE; 94068462. RA Damm K., Evans R. M. RT Identification of a domain required for oncogenic activity and RT transcriptional suppression by v-erbA and thyroid-hormone receptor alpha RL Proc. Natl. Acad. Sci. USA 90:10668-10672 (1993). RN [6] RX MEDLINE; 92127595. RA Leid M., Kastner P., Lyons R., Nakshatri H., Saunders M., Zacharewski T., RA Chen J.-Y., Staub A., Garnier J.-M., Mader S., Chambon P. RT Purification, cloning, and RXR identity of the HeLa cell factor with which RT RAR or TR heterodimerizes to bind target sequences efficiently RL Cell 68:377-395 (1992). RN [7] RX MEDLINE; 92131129. RA Zhang X. K., Hoffmann B., Tran P. B.-V., Graupner G., Pfahl M. RT Retinoid X receptor is an auxiliary protein for thyroid hormone and RT retinoic acid receptors RL Nature 355:441-446 (1992). RN [8] RX MEDLINE; 93066223. RA Ross T. K., Prahl J. M., Herzberg I. M., DeLuca H. F. RT Baculovirus-mediated expression of retinoic acid receptor type gamma in RT cultured insect cells reveals a difference in specific DNA-binding behavior RT with the 1,25-dihydroxyvitamin D3 receptor RL Proc. Natl. Acad. Sci. USA 89:10282-10286 (1992). RN [9] RX MEDLINE; 92103690. RA Yu V. C., Delsert C., Andersen B., Holloway J. M., Devary O. V., Naeaer A. RA M., Kim S. Y., Boutin J. M., Glass C. K., Rosenfeld M. G. RT RXRbeta: a coregulator that enhances binding of retinoic acid, thyroid RT hormone, and vitamin D receptors of their cognate response elements RL Cell 67:1251-1266 (1991). RN [10] RX MEDLINE; 91330303. RA Mangelsdorf D. J., Umesono K., Kliewer S. A., Borgmeyer U., Ong E. S., RA Evans R. M. RT A direct repeat in the cellular retinol-binding protein type II gene RT confers differential regulation by RXR and RAR RL Cell 66:555-561 (1991). RN [11] RX MEDLINE; 92037546. RA Vivanco Ruiz M. d. M., Bugge T. H., Hirschmann P., Stunnenberg H. G. RT Functional characterization of a natural retinoic acid responsive element RL EMBO J. 10:3829-3838 (1991). RN [12] RX MEDLINE; 91219411. RA Yang N., Schuele R., Mangelsdorf D. J., Evans R. M. RT Characterization of DNA binding and retinoic acid binding properties of RT retinoic acid receptor RL Proc. Natl. Acad. Sci. USA 88:3559-3563 (1991). RN [13] RX MEDLINE; 92052226. RA Leroy P., Nakshatri H., Chambon P. RT Mouse retinoic acid receptor alpha2 isoform is transcribed from a promoter RT that contains a retinoic acid response element RL Proc. Natl. Acad. Sci. USA 88:10138-10142 (1991). RN [14] RX MEDLINE; 91029504. RA Glass C. K., Devary O. V., Rosenfeld M. G. RT Multiple cell type-specific proteins differentially regulate target RT sequence recognition by the alpha retinoic acid receptor RL Cell 63:729-738 (1990). RN [15] RX MEDLINE; 91092269. RA Nicholson R. C., Mader S., Nagpal S., Leid M., Rochette-Egly C., Chambon P. RT Negative regulation of the rat stromelysin gene promoter by retinoic acid RT is mediated by an AP1 binding site RL EMBO J. 9:4443-4454 (1990). RN [16] RX MEDLINE; 90114439. RA de The H., del Mar Vivanco-Ruiz M., Tiollais P., Stunnenberg H., Dejean A. RT Identification of a retinoic acid responsive element in the retinoic acid RT receptor beta gene RL Nature 343:177-180 (1990). RN [17] RX MEDLINE; 90319119. RA Sucov H. M., Murakami K. K., Evans R. M. RT Characterization of an autoregulated response element in the mouse retinoic RT acid receptor type beta gene RL Proc. Natl. Acad. Sci. USA 87:5392-5396 (1990). XX // AC G000377 XX ID HS$RARG XX DT 14.06.1995 (created); dbo. DT 29.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD RARG XX DE retinoic acid receptor gamma XX SY RAR-gamma; NR1B3; RARC. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 12q13 XX BC 6.1.2.2 XX BS -397 -380 R03929; HS$RARG_01; Binding factors: RAR-alpha1 , BS RAR-gamma , RAR-beta , RXR-alpha . XX FA T00720; RAR-gamma. FA T01330; RAR-gamma1. XX DR EMBL: X57280; HSRARG2D. DR TRANSPATH: G000377. DR LOCUSLINK: 5916. DR OMIM: 180190. DR REFSEQ: NM_000966. XX RN [1] RX MEDLINE; 92318914. RA Lehmann J. M., Zhang X.-K., Pfahl M. RT RARgamma2 expression is regulated through a retinoic acid response element RT embedded in Sp1 sites RL Mol. Cell. Biol. 12:2976-2985 (1992). XX // AC G000378 XX ID HS$HRAS XX DT 14.06.1995 (created); dbo. DT 28.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD HRAS XX SY HRAS1; c-Ha-ras1; p21ras. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.5 XX BC 6.1.5.16 XX BS empty empty R01311; HS$RAS1_07; Binding factors: CTF-1 , CTF-2 BS , CTF-3 . BS -28 -8 R04834; HS$RAS1_08; Binding factors: Sp1 . BS 262 271 R01305; HS$RAS1_01; Binding factors: Sp1 . BS 289 298 R01306; HS$RAS1_02; Binding factors: Sp1 . BS 340 349 R01307; HS$RAS1_03; Binding factors: Sp1 . BS 400 409 R01308; HS$RAS1_04; Binding factors: Sp1 . BS 509 518 R01309; HS$RAS1_05; Binding factors: Sp1 . BS 520 529 R01310; HS$RAS1_06; Binding factors: Sp1 . BS 1215 1237 R11700; HS$RAS1_09; Binding factors: p53 . XX DR EMBL: M13221; HSCRAS1P. DR EMBL: J00277; HSRASH. DR TRANSPATH: G000378. DR LOCUSLINK: 3265. DR OMIM: 190020. DR REFSEQ: NM_005343. XX RN [1] RX MEDLINE; 98324711. RA Zachos G., Spandidos D. A. RT Transcriptional regulation of the c-H-ras1 gene by the P53 protein is RT implicated in the development of human endometrial and ovarian tumours. RL Oncogene 16:3013-3017 (1998). RN [2] RX MEDLINE; 94268916. RA Mayfield C., Miller D. RT Effect of abasic linker substitution on triplex formation, Sp1 binding, and RT specificity in an oligonucleotide targeted to the human Ha-ras promoter RL Nucleic Acids Res. 22:1909-1916 (1994). RN [3] RX MEDLINE; 88288392. RA Santoro C., Mermod N., Andrews P. C., Tjian R. RT A family of human CCAAT-box-binding proteins active in transcription and RT DNA replication: cloning and expression of multiple cDNAs RL Nature 334:218-224 (1988). RN [4] RX MEDLINE; 86235432. RA Ishii S., Kadonaga J. T., Tjian R., Brady J. N., Merlin G. T., Pastan I. RT Binding of the Sp1 Transcription Factor by the Human Harvey ras1 RT Proto-oncogene Promoter RL Science 232:1410-1413 (1986). XX // AC G000379 XX ID HS$RBP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Rbp XX DE retinol binding protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 10q23-q24 XX BS -271 -247 R01322; HS$RBP_01; Binding factors: NF-1/L . XX DR EMBL: M33864; HSIRBPW1. DR EMBL: X02775; HSRPBG1. DR TRANSPATH: G000379. DR LOCUSLINK: 5950. DR OMIM: 180250. DR REFSEQ: NM_006744. XX RN [1] RX MEDLINE; 89030607. RA Paonessa G., Gounari F., Frank R., Cortese R. RT Purification of a NF1-like DNA-binding protein from rat liver and cloning RT of the corresponding cDNA RL EMBO J. 7:3115-3123 (1988). XX // AC G000380 XX ID HS$L7A XX DT 21.05.1996 (created); ake. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD rpL7a XX DE ribosomal protein L7a, Surf-3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 9q33-q34 XX BC 6.1.2.3.2 XX DR TRRD: 00135. DR LOCUSLINK: 6130. DR OMIM: 185640. DR REFSEQ: NM_000972. XX // AC G000381 XX ID HS$SAA XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD SAA XX DE serum amyloid A XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.1-p14 XX BC 6.1.3.4 XX BS -91 -82 R01349; HS$SAA_01; Binding factors: NF-kappaB(-like) . XX DR EMBL: L05921; HSAPSAA. DR EMBL: M26698; HSSAAA. DR TRANSPATH: G000381. DR LOCUSLINK: 6288. DR OMIM: 104750. DR REFSEQ: NM_000331. XX RN [1] RX MEDLINE; 89313734. RA Edbrooke M. R., Burt D. W., Cheshire J. K., Woo P. RT Identification of cis-Acting Sequences Responsible for Phorbol Ester RT Induction of Human Serum A Gene Expression via a Nuclear Factor kB-Like RT Transcription Factor RL Mol. Cell. Biol. 9:1908-1916 (1989). XX // AC G000382 XX ID HS$SAA2 XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD SAA2 XX DE serum amyloid A2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11p15.1-p14 XX BC 6.1.3.4 XX BS -188 -179 R04480; HS$SAA2_01; Binding factors: C/EBPbeta . XX DR EMBL: L05921; HSAPSAA. DR TRANSPATH: G000382. DR TRANSCOMPEL: C00100. DR LOCUSLINK: 6289. DR OMIM: 104751. DR REFSEQ: NM_030754. XX RN [1] RX MEDLINE; 94064632. RA Betts J. C., Cheshire J. K., Akira S., Kishimoto T., Woo P. RT The role of NF-kappaB and NF-IL6 transactivating factors in the synergistic RT activation of human serum amyloid A gene expression by interleukin-1 and RT interleukin-6 RL J. Biol. Chem. 268:25624- 25631 (1993). XX // AC G000384 XX ID HS$SAAG9 XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD SAAg9 XX DE serum amyloid Ag9 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.3.4 XX DR TRRD: 00213. XX // AC G000385 XX ID HS$SI XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD SI XX DE sucrase-isomaltase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 3q25-q26 XX BC 6.1.4 XX BS -174 -157 R04237; HS$SI_01; Binding factors: HNF-1A , HNF-1B BS . BS -86 -74 R04238; HS$SI_02; Binding factors: HNF-1A , HNF-1B BS . BS -56 -34 R04239; HS$SI_03; Binding factors: Cdx-2 . XX DR EMBL: M84646; HSSIPT. DR TRANSPATH: G000385. DR BRENDA: 3.2.1.48; Human. DR BRENDA: 3.2.1.10; Human. DR LOCUSLINK: 6476. DR OMIM: 222900. DR REFSEQ: NM_001041. XX RN [1] RX MEDLINE; 97315318. RA Taylor J. K., Levy T., Suh E. R., Traber P. G. RT Activation of enhancer elements by the homeobox gene Cdx2 is cell line RT specific RL Nucleic Acids Res. 25:2293-2300 (1997). RN [2] RX MEDLINE; 96140429. RA Suh E., Traber P. G. RT An intestine-specific homeobox gene regulates proliferation and RT differentiation RL Mol. Cell. Biol. 16:619-625 (1996). RN [3] RX MEDLINE; 94274696. RA Wu G. D., Chen L., Forslund K., Traber P. G. RT Hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta regulate RT transcription via two elements in an intestine-specific promoter RL J. Biol. Chem. 269:17080-17085 (1994). RN [4] RX MEDLINE; 94200389. RA Troelsen J. T., Olsen J., Mitchelmore C., Hansen G. H., Sjoestroem H., RA Noren O. RT Two intestinal specific nuclear factors binding to the lactase-phlorizin RT hydrolase and sucrase-isomaltase promoters are functionally related RT oligomeric molecules RL FEBS Lett. 342:297-301 (1994). RN [5] RX MEDLINE; 92334363. RA Traber P. G., Wu G. D., Wang W. RT Novel DNA-binding proteins regulate intestine-specific transcription of the RT sucrase-isomaltase gene RL Mol. Cell. Biol. 12:3614-3627 (1992). XX // AC G000386 XX ID HS$RNPE XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD snRNP E XX DE small nuclear ribonucleoprotein E XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1q25-q43 XX BC 6.1.2.3.1 XX BS -30 -8 R03887; HS$RNPE_01. BS -5 5 R03888; HS$RNPE_02. XX DR EMBL: M21253; HSSNRNP3. DR TRRD: 00144. DR LOCUSLINK: 6635. DR OMIM: 128260. DR REFSEQ: NM_003094. XX RN [1] RX MEDLINE; 92078203. RA Fautsch M. P., Wieben E. D. RT Transcriptional regulation of the small nuclear rinonucleoprotein E protein RT gene RL J. Biol. Chem. 266:23288-23295 (1991). XX // AC G000387 XX ID HS$SR XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD SR XX DE macrophage scavenger receptor XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX DR TRANSPATH: G000387. DR TRANSCOMPEL: C00079. DR TRANSCOMPEL: C00080. XX // AC G000388 XX ID HS$SRY XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD SRY XX DE sex-determining region Y XX SY TDF. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH Yp11.3 XX BS -24 1 R03578; HS$SRY_01; Binding factors: SRY . XX FA T00997; SRY. XX DR EMBL: L10102; HSSRYB. DR TRANSPATH: G000388. DR LOCUSLINK: 6736. DR OMIM: 480000. DR REFSEQ: NM_003140. XX RN [1] RX MEDLINE; 92132550. RA Harley V. R., Jackson D. I., Hextall P. J., Hawkins J. R., Berkovitz G. D., RA Sockanathan S., Lovell-Badge R., Goodfellow P. N. RT DNA binding activity of recombinant SRY from normal males and XY females RL Science 255:453-456 (1992). XX // AC G000389 XX ID HS$MMP3 XX DT 14.06.1995 (created); dbo. DT 29.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD MMP3 XX DE matrix metalloproteinase 3 (stromelysin 1, progelatinase) XX SY STMY1; STMY; stromelysin 1; progelatinase. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 11q22.3 XX BC 6.1.4.7.3 XX BS -1626 -1599 R11771; HS$ST_04; Binding factors: ZBP89 . BS -1265 -1253 R05063; HS$ST_03; Binding factors: FOXF1 . BS -100 -78 R03058; HS$ST_01; Binding factors: NIP , PEA3 BS . BS -77 -55 R03059; HS$ST_02; Binding factors: AP-1 , AP-1 BS , c-Fos , c-Jun . XX DR EMBL: AF405705; AF405705. DR EMBL: U43511; HS4351110. DR EMBL: J04732; HSSTMY. DR TRANSPATH: G000389. DR BRENDA: 3.4.24.17; Human. DR TRRD: 00214. DR LOCUSLINK: 4314. DR OMIM: 185250. DR REFSEQ: NM_002422. XX RN [1] RX MEDLINE; 99285582. RA Ye S., Whatling C., Watkins H., Henney A. RT Human stromelysin gene promoter activity is modulated by transcription RT factor ZBP-89. RL FEBS Lett. 450:268-272 (1999). RN [2] RX MEDLINE; 98145936. RA Peterson R. S., Linn L., Ye H., Zhou H., Overdier D. G., Costa R. H. RT The winged helix transcriptional activator HFH-8 is expressed in the RT mesoderm of the primitive streak stage of mouse embryos and its cellular RT derivatives RL Mech. Dev. 69:53-69 (1997). RN [3] RX MEDLINE; 91195056. RA Sirum-Connolly K., Brinckerhoff C. E. RT Interleukin-1 or phorbol induction of the stromelysin promoter requires an RT element that cooperates with AP-1 RL Nucleic Acids Res. 19:335-341 (1991). RN [4] RX MEDLINE; 91305122. RA Buttice G., Quinones S., Kurkinen M. RT The AP-1 site is required for basal expression but is not necessary for RT TPA-response of the human stromelysin gene RL Nucleic Acids Res. 19:3723-3731 (1991). RN [5] RX MEDLINE; 91092269. RA Nicholson R. C., Mader S., Nagpal S., Leid M., Rochette-Egly C., Chambon P. RT Negative regulation of the rat stromelysin gene promoter by retinoic acid RT is mediated by an AP1 binding site RL EMBO J. 9:4443-4454 (1990). XX // AC G000390 XX ID HS$TCRA XX DT 14.06.1995 (created); dbo. DT 16.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD TCR-alpha XX DE T-cell receptor alpha XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.6.5.2 XX BS empty empty R02795; HS$TCRA_03; Binding factors: AP-2alphaA , BS GATA-3 , NF-kappaE2 , AP-2alphaB . BS empty empty R02796; HS$TCRA_04. BS empty empty R03916; HS$TCRA_06; Binding factors: ATF4 . BS empty empty R03917; HS$TCRA_07. BS empty empty R04450; HS$TCRA_08; Binding factors: c-Ets-1 , LEF-1 BS , PEBP2alphaA1 . BS empty empty R08617; HS$TCRA_09; Binding factors: TCF-3 . BS 21 46 R02794; HS$TCRA_02. BS 62 76 R08631; HS$TCRA_10; Binding factors: LEF-1 , LEF-1 BS . BS 65 103 R02098; HS$TCRA_01; Binding factors: c-Ets-1 . XX DR EMBL: M94081; HSTCRADCV. DR EMBL: M30267; HSTCRAEE. DR TRANSPATH: G000390. DR TRANSCOMPEL: C00174. DR SMARTDB: SM0000411. XX RN [1] RX MEDLINE; 96338228. RA Behrens J., von Kries J. P., Kuehl M., Bruhn L., Wedlich D., Grosschedl R., RA Birchmeier W. RT Functional interaction of beta-catenin with the transcription factor LEF -1 RL Nature 382:638-642 (1996). RN [2] RX MEDLINE; 98454908. RA Molenaar M., van de Wetering M., Oosterwegel M., Peterson-Maduro J., RA Godsave S., Korinek V., Roose J., Destree O., Clevers H. RT XTcf-3 transcription factor mediates beta-catenin-induced axis formation in RT Xenopus embryos RL Cell 86:391-399 (1996). RN [3] RX MEDLINE; 95293231. RA Giese K., Kingsley C., Kirshner J. R., Grosschedl R. RT Assembly and function of a TCRalpha enhancer complex is dependent on RT LEF-1-induced DNA bending and multiple protein-protein interactions RL Genes Dev. 9:995-1008 (1995). RN [4] RX MEDLINE; 92279218. RA Karpinski B. A., Morle G. D., Huggenvik J., Uhler M. D., Leiden J. M. RT Molecular cloning of human CREB-2: An ATF/CREB transcription factor that RT can negatively regulate transcription from the cAMP response element RL Proc. Natl. Acad. Sci. USA 89:4820-4824 (1992). RN [5] RX MEDLINE; 91216113. RA Ho I.-C., Vorhees P., Marin N., Oakley B. K., Tsai S.-F., Orkin S. H., RA Leiden J. M. RT Human GATA-3: a lineage-restricted transcription factor that regulates the RT expression of the T cell receptor alpha gene RL EMBO J. 10:1187-1192 (1991). RN [6] RX MEDLINE; 91224496. RA Travis A., Amsterdam A., Belanger C., Grosschedl R. RT LEF-1, a gene encoding a lymphoid-specific with protein, an HMG domain, RT regulates T-cell receptor alpha enhancer function RL Genes Dev. 5:880-894 (1991). RN [7] RX MEDLINE; 91217625. RA Oosterwegel M., van de Wetering M., Dooijes D., Klomp L., Winoto A., RA Georgopoulos K., Meijlink F., Clevers H. RT Cloning of murine TCF-1, a T cell-specific transcription factor interacting RT with functional motifs in the CD3-epsilon and T cell receptor alpha RT enhancers RL J. Exp. Med. 173:1133-1142 (1991). RN [8] RX MEDLINE; 90355988. RA Ho I-Ch., Leiden J. M. RT Regulation of the human T-cell receptor alpha gene enhancer: Multiple RT ubiquitous and T-cell-specific nuclear proteins interact with four RT hypomethylated enhancer elements RL Mol. Cell. Biol. 10:4720-4727 (1990). RN [9] RX MEDLINE; 91047994. RA Ho I.-C., Bhat N., Gottschalk L. R., Lindstein T., Thompson C. B., Papas T. RA S., Leiden J. M. RT Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene RT enhancer RL Science 250:814-818 (1990). XX // AC G000393 XX ID HS$TCRBL XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD TCR-beta XX DE T-cell receptor beta XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.6.5.2 XX BS empty empty R03723; HS$TCRBL_10; Binding factors: GATA-3 . BS 34 47 R02412; HS$TCRBL_01. BS 205 228 R02413; HS$TCRBL_02; Binding factors: AP-1 . BS 275 292 R02414; HS$TCRBL_03; Binding factors: c-Ets-1 68 . BS 349 394 R02415; HS$TCRBL_04; Binding factors: c-Ets-1 68 . BS 457 470 R02416; HS$TCRBL_05. BS 1250 1264 R02689; HS$TCRBL_06. BS 1268 1303 R02690; HS$TCRBL_07. BS 1341 1365 R02691; HS$TCRBL_08. BS 1367 1373 R02692; HS$TCRBL_09. XX DR EMBL: X59486; HSTCRBETA. DR EMBL: M58747; HSTCRENH. DR TRANSPATH: G000393. DR TRANSCOMPEL: C00020. XX RN [1] RX MEDLINE; 93028577. RA Prosser H. M., Wotton D., Gegonne A., Ghysdael J., Wang S., Speck N. A., RA Owen M. J. RT A phorbol ester response element within the human T-cell receptor RT beta-chain enhancer RL Proc. Natl. Acad. Sci. USA 89:9934-9938 (1992). RN [2] RX MEDLINE; 91334450. RA Marine J., Winoto A. RT The human enhancer-binding protein Gata3 binds to several T-cell receptor RT regulatory elemets RL Proc. Natl. Acad. Sci. USA 88:7284-7288 (1991). RN [3] RX MEDLINE; 90377239. RA Gottschalk L. R., Leiden J. M. RT Identification and functional characterization of the human T-cell receptor RT beta gene transactivation enhancer: common nuclear proteins interact with RT the transcriptional regulatory elements of the T-cell receptor alpha and RT beta genes RL Mol. Cell. Biol. 10:5486-5495 (1990). RN [4] RX MEDLINE; 90272410. RA Hashimoto Y., Maxam A. M., Greene M. I. RT Identification of tissue specific nuclear proteins: DNA sequence and RT protein binding regions in the T cell receptor beta J-C intron RL Nucleic Acids Res. 18:3027-3033 (1990). XX // AC G000395 XX ID HS$TRDL XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD TCR-delta XX DE T-cell receptor delta XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.6.5.2 XX BS 909 935 R01431; HS$TRDL_03; Binding factors: c-Myb , BS NFdeltaE3A , NFdeltaE3B , NFdeltaE3C , PEBP2alphaA1 BS . BS 1093 1120 R01429; HS$TRDL_01. BS 1129 1160 R01430; HS$TRDL_02. BS 1270 1300 R01432; HS$TRDL_04; Binding factors: GATA-1 , GATA-3 BS , NFdeltaE4A , NFdeltaE4B , NFdeltaE4C . BS 1310 1323 R01433; HS$TRDL_05. BS 1340 1354 R01434; HS$TRDL_06. BS 1362 1373 R01435; HS$TRDL_07. XX DR EMBL: M94081; HSTCRADCV. DR TRANSPATH: G000395. DR TRANSCOMPEL: C00003. DR SMARTDB: SM0000408. DR SMARTDB: SM0000409. DR SMARTDB: SM0000410. XX RN [1] RX MEDLINE; 95280907. RA Hernandez-Munain C., Krangel M. S. RT c-Myb and core-binding factor / PEBP2 display functional synergy but bind RT independently to adjacent sites in the T-cell receptor delta enhancer RL Mol. Cell. Biol. 15:3090-3099 (1995). RN [2] RX MEDLINE; 93024427. RA Redondo J. M., Pfohl J. L., Hernandez-Munain C., Wang S., Speck N. A., RA Krangel M. S. RT Indistinguishable nuclear factor binding to functional core sites of the RT T-cell receptor delta and murine leukemia virus enhancers RL Mol. Cell. Biol. 12:4817- 4823 (1992). RN [3] RX MEDLINE; 91266910. RA Joulin V., Bouries D., Eleouet J.-F., Labastie M.-C., Chretien S., Mattei RA M.-G., Romeo P.-H. RT A t-cell specific TCR delta DNA binding protein is a member of the human RT GATA family RL EMBO J. 10:1809-1816 (1991). RN [4] RX MEDLINE; 92017848. RA Redondo J. M., Pfohl J. L., Krangel M. S. RT Identification of an essential site for transcriptional activation within RT the human T-cell receptor delta enhancer RL Mol. Cell. Biol. 11:5671-5680 (1991). RN [5] RX MEDLINE; 91334450. RA Marine J., Winoto A. RT The human enhancer-binding protein Gata3 binds to several T-cell receptor RT regulatory elemets RL Proc. Natl. Acad. Sci. USA 88:7284-7288 (1991). RN [6] RX MEDLINE; 90193684. RA Redondo J. M., Hata S., Brocklehurst C., Krangel M. S. RT A T Cell-Specific Transcriptional Enhancer Within the Human T Cell Receptor RT delta Locus RL Science 247:1225-1229 (1990). XX // AC G000396 XX ID HS$TGFB1 XX DT 14.06.1995 (created); dbo. DT 19.11.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD TGF-beta1 XX DE transforming growth factor-beta1 XX SY CED; DPD1; TGFB; TGB-beta; DPD1; CED; TGB-beta; TGFB. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 19q13.1 XX BC 6.1.5.10 XX BS -453 -383 R01458; HS$TGFB1_01. BS -393 -323 R01459; HS$TGFB1_02. BS -165 20 R04755; HS$TGFB1_07; Binding factors: Sp1 . BS -125 -98 R04853; HS$TGFB1_09; Binding factors: Egr-1 , Egr-1 BS . BS -37 20 R04756; HS$TGFB1_08; Binding factors: Sp1 . BS 150 289 R01729; HS$TGFB1_04; Binding factors: AP-1 , Sp1 BS . BS 174 180 R01728; HS$TGFB1_03; Binding factors: Sp1 . BS 247 289 R01730; HS$TGFB1_05; Binding factors: AP-1 . XX DR EMBL: J04431; HSTGFB1PR. DR EMBL: X05839; HSTGFBG1. DR TRANSPATH: G000396. DR LOCUSLINK: 7040. DR OMIM: 190180. DR REFSEQ: NM_000660. XX RN [1] RX MEDLINE; 94148881. RA Kim S. J., Park K., Rudkin B. B., Dey B. R., Sporn M. B., Roberts A. B. RT Nerve growth factor induces trancription of transforming growth RT factor-beta1 through a specific promoter element in PC12 cells RL J. Biol. Chem. 269:3739-3744 (1994). RN [2] RX MEDLINE; 93314966. RA Geiser A. G., Busam K. J., Kim S.-J., Lafyatis R., O'Reilly M. A., Webbink RA R., Roberts A. B., Sporn M. B. RT Regulation of the transforming growth factor-beta1 and -beta3 promoters by RT transcription factor Sp1 RL Gene 129:223-228 (1993). RN [3] RX MEDLINE; 89214126. RA Kim S.-J., Jeang K.-T., Glick A. B., Sporn M. B., Roberts A. B. RT Promoter Sequences of the Human Transforming Growth Factor-beta1 Gene RT Responsive to Transforming Growth Factor-beta1 Autoinduction RL J. Biol. Chem. 264:7041-7045 (1989). RN [4] RX MEDLINE; 90037078. RA Kim S.-J., Denhez F., Kim K. Y., Holt J. T., Sporn M. B., Roberts A. B. RT Activation of the Second Promoter of the Transforming Growth Factor-beta1 RT Gene by Transforming Growth Factor-beta1 and Phorbol Ester Occurs through RT the Same Target Sequences RL J. Biol. Chem. 264:19373-19378 (1989). XX // AC G000397 XX ID HS$TGFB2 XX DT 14.06.1995 (created); dbo. DT 19.11.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD TGF-beta2 XX DE transforming growth factor-beta2 XX SY G-TsF; TGB-beta-2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1q41 XX BC 6.1.5.10 XX BS -77 -63 R03918; HS$TGFB2_01; Binding factors: CRE-BP1 , ATF-1 BS . XX DR EMBL: M87843; HSTGFBET2. DR TRANSPATH: G000397. DR TRRD: 00089. DR LOCUSLINK: 7042. DR OMIM: 190220. DR REFSEQ: NM_003238. XX RN [1] RX MEDLINE; 92350254. RA Kim S.-J., Wagner S., Liu F., O'Reilly M. A., Robbins P. D., Green M. R. RT Retinoblastoma gene product activates expressionof the human TGF-beta2 gene RT through transcription factor ATF-2 RL Nature 358:331-334 (1992). XX // AC G000398 XX ID HS$T1G XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GLOB-T1 XX DE theta1-globin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 16p13.3 XX BC 6.1.3.9.2 XX BS -94 -59 R01860; HS$T1G_01. BS -57 -35 R01861; HS$T1G_02. XX DR EMBL: M91453; HSAGLOB. DR EMBL: X06482; HSGLTH1. DR EMBL: M33022; HSHBQ1A. DR LOCUSLINK: 3049. DR OMIM: 142240. DR REFSEQ: NM_005331. XX RN [1] RX MEDLINE; 89345161. RA Kim J.-H., Yu C.-Y., Bailey A., Hardison R., Shen C.-K. J. RT Unique sequence organization and erythroid cell-specific nuclear RT factor-binding of mammalian 1 globin promoters RL Nucleic Acids Res. 17:5687-5700 (1989). XX // AC G000399 XX ID HS$TK1 XX DT 14.06.1995 (created); dbo. DT 29.05.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD tk1 XX DE thymidine kinase 1 XX SY TK1, soluble. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 17q23.2-q25.3 XX BC 6.1.4.2 XX BS -263 -257 R08677; HS$TK_09; Binding factors: Sp1 . BS -251 -245 R08676; HS$TK_08; Binding factors: Sp1 . BS -232 -227 R08675; HS$TK_07; Binding factors: Sp1 . BS -221 -215 R08674; HS$TK_06; Binding factors: Sp1 . BS -133 -64 R03039; HS$TK_01; Binding factors: CP1 . BS -120 -113 R08671; HS$TK_05; Binding factors: Sp1 . BS -97 -89 R08663; HS$TK_03; Binding factors: E2F . BS -83 -53 R03040; HS$TK_02; Binding factors: CP1 . BS -54 -47 R08667; HS$TK_04; Binding factors: Sp1 . XX DR EMBL: M13643; HSTKA. DR TRANSPATH: G000399. DR BRENDA: 2.7.1.21; Human. DR TRRD: 00298. DR LOCUSLINK: 7083. DR OMIM: 188300. DR REFSEQ: NM_003258. XX RN [1] RX MEDLINE; 98043756. RA Tommasi S., Pfeifer G. P. RT Constitutive protection of E2F recognition sequences in the human thymidine RT kinase promoter during cell cycle progression RL J. Biol. Chem. 272:30483-30490 (1997). RN [2] RX MEDLINE; 96069400. RA Tommasi S., Pfeifer G. P. RT In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 RT complex from sequences immediately upstream of the transcription initiation RT site coincides with induction of cdc2 expression RL Mol. Cell. Biol. 15:6901-6913 (1995). RN [3] RX MEDLINE; 91172220. RA Kim Y. K., Lee A. S. RT Identification of a 70-base-pair cell cycle regulatory unit within the RT promoter of the human thymidine kinase gene and its interaction with RT cellular factors RL Mol. Cell. Biol. 11:2296-2302 (1991). XX // AC G000400 XX ID HS$TNFA XX DT 14.06.1995 (created); dbo. DT 06.06.2002 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD TNF-alpha XX DE tumor necrosis factor alpha XX SY TNFSF2; DIF; TNFA. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.5.11 XX BS -165 -144 R08185; HS$TNFA_02. BS -125 -82 R03186; HS$TNFA_01; Binding factors: c-Jun . BS -121 -107 R08186; HS$TNFA_03. BS -98 -84 R08187; HS$TNFA_04. BS -84 -67 R08188; HS$TNFA_05. XX DR EMBL: X02910; HSTNFA. DR TRANSPATH: G000400. DR TRANSCOMPEL: C00144. DR TRANSCOMPEL: C00178. DR TRANSCOMPEL: C00266. DR TRANSCOMPEL: C00318. DR TRRD: 00266. XX RN [1] RX MEDLINE; 96140410. RA Tsai E. Y., Jain J., Pesavento P. A., Rao A., Goldfeld A. E. RT Tumor necrosis factor alpha gene regulation in activated T cells involves RT ATF-2/Jun and NFATp RL Mol. Cell. Biol. 16:459-467 (1996). RN [2] RX MEDLINE; 96413274. RA Tsai E. Y., Yie J., Thanos D., Goldfeld A. E. RT Cell-type-specific regulation of the human tumor necrosis factor alpha gene RT in B cells and T cells by NFATp and ATF-2/Jun RL Mol. Cell. Biol. 16:5232-5244 (1996). RN [3] RX MEDLINE; 96399098. RA Prieschl E. E., Pendl G. G., Elbe A., Serfling E., Harrer N. E., Stingl G., RA Baumruker T. RT Induction of the TNF-alpha promoter in the murine dendritic cell line 18 RT and the murine mast cell line CPII is differently regulated RL J. Immunol. 157:2645-2653 (1996). RN [4] RX MEDLINE; 91236691. RA Leitman D. C., Ribeiro R. C. J., Mackow E. R., Baxter J. D., West B. L. RT Identification of a tumor necrosis factor-responsive element in the tumor RT necrosis factor alpha gene RL J. Biol. Chem. 266:9343-9346 (1991). XX // AC G000401 XX ID HS$TNFB XX DT 14.06.1995 (created); dbo. DT 27.05.2002 (updated); elf. CO Copyright (C), Biobase GmbH. XX SD TNF-beta XX DE tumor necrosis factor-beta XX SY TNF-beta; LT; TNFB; TNFSF1; lymphotoxin A. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6p21.3 XX BC 6.1.5.11 XX BS -100 -88 R02923; HS$TNFB_01; Binding factors: NF-kappaB . XX DR EMBL: X02911; HSTNFB. DR TRANSPATH: G000401. DR LOCUSLINK: 4049. DR OMIM: 153440. DR REFSEQ: NM_000595. XX RN [1] RX MEDLINE; 91012785. RA Paul N. L., Lenardo M. J., Novak K. D., Sarr T., Tang W.-L., Ruddle N. H. RT Lymphotoxin activation by human T-cell leukemia virus type I-infected cell RT lines: Role for NF-kappaB RL J. Virol. 64:5412-5419 (1990). XX // AC G000402 XX ID HS$TPA XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD tPA XX DE tissue-type plasminogen activator XX SY t-PA. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 8p12-q11.2 XX BC 6.1.4.7.1 XX BS -115 -102 R04029; HS$TPA_01; Binding factors: CREB , CREB BS , CRE-BP1 , CREB . BS 60 74 R04030; HS$TPA_02. XX DR EMBL: K03021; HSTPA. DR TRANSPATH: G000402. DR LOCUSLINK: 5327. DR OMIM: 173370. DR REFSEQ: NM_033011. XX RN [1] RX MEDLINE; 96235215. RA Costa M., Medcalf R. L. RT Differential binding of cAMP-responsive-element(CRE)-binding protein-1 and RT activating transcription factor-2 to a CRE-like element in the human RT tissue-type plasminogen activator (t-PA) gene promoter correlates with RT opposite regulation of t-PA RL Eur. J. Biochem. 237:532-538 (1996). RN [2] RX MEDLINE; 95361871. RA Holmberg M., Leonardsson G., Ny T. RT The species-specific differences in the cAMP regulation of the tissue-type RT plasminogen activator gene between rat, mouse and human is caused by a RT one-nucleotide substitution in the cAMP-responsive element of the promoter RL Eur. J. Biochem. 231:466-474 (1995). RN [3] RX MEDLINE; 90354460. RA Medcalf R. L., Rueegg M., Schleuning W.-D. RT A DNA motif related to the cAMP-responsive element and an exonlocated RT activator protein-2 binding site in the human tissue-type plasminogen RT activator gene promoter cooperate in basal expression and convey activation RT by phorbol ester and cAMP RL J. Biol. Chem. 265:14618-14626 (1990). XX // AC G000403 XX ID HS$TPI XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD TPI XX DE triosephosphate isomerase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 12p13 XX BC 6.1.4 XX BS -120 0 R02857; HS$TPI_01; Binding factors: Sp1 . BS -110 0 R02858; HS$TPI_02; Binding factors: Sp1 . BS -80 0 R02859; HS$TPI_03; Binding factors: Sp1 . BS -50 0 R02860; HS$TPI_04; Binding factors: Sp1 . BS -18 1 R02861; HS$TPI_05. XX DR EMBL: M10036; HSTPI. DR TRANSPATH: G000403. DR BRENDA: 5.3.1.1; Human. DR LOCUSLINK: 7167. DR OMIM: 190450. DR REFSEQ: NM_000365. XX RN [1] RX MEDLINE; 91056103. RA Boyer T. G., Maquat L. E. RT Minimal sequence and factor requirements for the initiation of RT transcription from an atypical, TATATAA box-containing housekeeping promoter RL J. Biol. Chem. 265:20524-20532 (1990). XX // AC G000404 XX ID HS$TPO XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD TPO XX DE thyroid peroxidase XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 2pter-p24 XX BC 6.1.4 XX BS 83 100 R02470; HS$TPO_01. BS 123 155 R02471; HS$TPO_02; Binding factors: TTF-1 . BS 144 169 R02472; HS$TPO_03. BS 200 219 R02473; HS$TPO_04. XX DR TRANSPATH: G000404. DR BRENDA: 1.11.1.8; Human. DR LOCUSLINK: 7173. DR OMIM: 274500. DR OMIM: 606765. DR REFSEQ: NM_000547. XX RN [1] RX MEDLINE; 92017767. RA Mizuno K., Gonzales F. J., Kimura S. RT Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional RT characterization, and structural identity with thyroid transcription factor RT TTF-1 RL Mol. Cell. Biol. 11:4927-4993 (1991). RN [2] RX MEDLINE; 91061727. RA Kikkawa F., Gonzalez F. J., Kimura S. RT Characterization of a thyroid-specific enhancer located 5.5 kilobase pairs RT upstream of the human thyroid peroxidase gene RL Mol. Cell. Biol. 10:6216-6224 (1990). XX // AC G000405 XX ID HS$TF XX DT 14.06.1995 (created); dbo. DT 24.08.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Tf XX DE transferrin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 3q21 XX BC 6.1.3 XX BS -614 -591 R01453; HS$TF_04. BS -474 -454 R01454; HS$TF_05; Binding factors: Tf-LF2 , Tf-LF2 BS . BS -440 -425 R03194; HS$TF_10. BS -193 -162 R01455; HS$TF_06; Binding factors: CTF , NF-1 BS . BS -103 -83 R01456; HS$TF_07; Binding factors: C/EBPalpha , BS C/EBPalpha . BS -76 -48 R01457; HS$TF_08; Binding factors: COUP-TF1 , BS HNF-4alpha1 , Tf-LF1 , Tf-LF1 , HNF-4alpha2 BS , HNF-4alpha1 . BS -34 -18 R03195; HS$TF_11; Binding factors: TFIID . BS 58 125 R01450; HS$TF_01. BS 64 72 R03693; HS$TF_12; Binding factors: EBP40 , EBP45 BS . BS 145 161 R03193; HS$TF_09. BS 170 201 R10350; HS$TF_13; Binding factors: HIF-1 , HIF-1 BS . BS 189 222 R01451; HS$TF_02. BS 232 281 R01452; HS$TF_03. XX DR EMBL: M15673; HSTFA01. DR EMBL: X04600; HSTFG5. DR EMBL: M62823; HSTRANSF. DR TRANSPATH: G000405. DR TRRD: 00087. DR LOCUSLINK: 7018. DR OMIM: 190000. DR REFSEQ: NM_001063. XX RN [1] RX MEDLINE; 97390444. RA Rolfs A., Kvietikova I., Gassmann M., Wenger R. H. RT Oxygen-regulated transferrin expression is mediated by hypoxia-inducible RT factor-1. RL J. Biol. Chem. 272:20055-20062 (1997). RN [2] RX MEDLINE; 94117447. RA Nishiyori A., Tashiro H., Kimura A., Akagi K., Yamamura K.-i., Mori M., RA Takiguchi M. RT Determination of tissue specificity of the enhancer by combinatorial RT operation of tissue-enriched transcription factors (Both HNF-4 and RT C/EBPbeta are required for liver-specific activity of the ornithine RT transcarbamylase enhancer) RL J. Biol. Chem. 269:1323-1331 (1994). RN [3] RX MEDLINE; 94043134. RA Schaeffer E., Guillou F., Part D., Zakin M. M. RT A different combiation of transcription factors modulates the expression of RT the human transferrin promoter in liver and sertorli cells RL J. Biol. Chem. 268:23399-23048 (1993). RN [4] RX MEDLINE; 94067127. RA Theisen M., Behringer R. R., Cadd G. G., Brinster R. L., McKnight G. S. RT A C/EBP-binding site in the transferrin promoter is essential for RT expression in the liver but not the brain of transgenic mice RL Mol. Cell. Biol. 13:7666-7676 (1993). RN [5] RX MEDLINE; 91236762. RA Boissier F., Auge-Gouillou C., Schaeffer E., Zakin M. M. RT The enhancer of the human transferrin gene is organized in two structural RT and functional domains RL J. Biol. Chem. 266:9822-9828 (1991). RN [6] RX MEDLINE; 91236769. RA Guillou F., Zakin M. M., Part D., Boissier F., Schaeffer E. RT Sertoli cell-specific expression of the human transferrin gene RL J. Biol. Chem. 266:9876-9884 (1991). RN [7] RX MEDLINE; 92084734. RA Petropoulos I., Auge-Gouillou C., Zakin M. M. RT Characterization of the active part of the human transferrin gene enhancer RT and purification of two liver nuclear factors interacting with the TGTTTGC RT motif present in this region RL J. Biol. Chem. 266:24220-24225 (1991). RN [8] RX MEDLINE; 89214148. RA Schaeffer E., Boissier F., Py M.-C., Cohen G. N., Zakin M. M. RT Cell type-specific Expression of the Human Transferrin Gene RL J. Biol. Chem. 264:7153-7160 (1989). RN [9] RX MEDLINE; 89098374. RA Ochoa A., Brunel F., Mendelzon D., Cohen G. N., Zakin M. M. RT Different liver nuclear proteins bind to similar sequences in the 5' RT flanking regions of three hepatic genes RL Nucleic Acids Res. 17:119-133 (1989). RN [10] RX MEDLINE; 88273108. RA Brunel F., Ochoa A., Schaeffer E., Boissier F., Guillou Y., Cereghini S., RA Cohen G. N., Zakin M. M. RT Interaction of DNA-binding Proteins with the 5' Region of the Human RT Transferrin Gene RL J. Biol. Chem. 263:10180-10185 (1988). XX // AC G000406 XX ID HS$TFREC XX DT 14.06.1995 (created); dbo. DT 24.08.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD TFREC XX DE transferrin receptor XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 3q26.2-qter XX BC 6.1.5.15 XX BS -97 -77 R10395; HS$TFREC_02; Binding factors: HIF-1 . BS -80 -63 R03629; HS$TFREC_01; Binding factors: TREF1 , TREF2 BS . XX DR EMBL: X04664; HSTR5. DR EMBL: X05339; HSTRP. DR TRANSPATH: G000406. DR LOCUSLINK: 7037. DR OMIM: 190010. DR REFSEQ: NM_003234. XX RN [1] RX MEDLINE; 99377051. RA Lok C. N., Ponka P. RT Identification of a hypoxia response element in the transferrin receptor RT gene. RL J. Biol. Chem. 274:24147-24152 (1999). RN [2] RX MEDLINE; 92096482. RA Roberts M. R., Miskimins W. K., Ruddle F. H. RT Nuclear proteins TREF1 and TREF2 bind to the transcriptional control RT element of the transferrin receptor and appear to be associated as a RT heterodimer RL Cell Regulation 1:151-164 (1989). XX // AC G000407 XX ID HS$TSG6 XX DT 21.05.1996 (created); ake. DT 13.11.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD TSG-6 XX DE TNF-stimulated gene 6 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 2 XX BS -126 -119 R08085; HS$TSG6_02; Binding factors: c-Fos , c-Jun BS . BS -118 -97 R08086; HS$TSG6_03; Binding factors: C/EBPbeta . BS -92 -83 R04479; HS$TSG6_01; Binding factors: C/EBPbeta . XX DR EMBL: AJ413949; HSA413949. DR TRANSPATH: G000407. DR TRANSCOMPEL: C00115. DR TRANSCOMPEL: C00116. DR LOCUSLINK: 7130. DR OMIM: 600410. DR REFSEQ: NM_007115. XX RN [1] RX MEDLINE; 95181322. RA Klampfer L., Chen-Kiang S., Vilcek J. RT Activation of the TSG-6 gene by NF-IL6 requires two adjacent NF-IL6 binding RT sites RL J. Biol. Chem. 270:3677-3682 (1995). RN [2] RX MEDLINE; 95021184. RA Klampfer L., Lee T. H., Hsu W., Vilcek J., Chen-Kiang S. RT NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by RT tumor necrosis factor alpha and interleukin-1 RL Mol. Cell. Biol. 14:6561-6569 (1994). XX // AC G000408 XX ID HS$TSHB XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD TSHB XX DE thyrotropin beta subunit XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 1p13 XX BC 6.1.5.3 XX BS -128 -89 R03100; HS$TSHB_01; Binding factors: POU1F1 . BS -75 -58 R03101; HS$TSHB_02; Binding factors: POU1F1 . BS -4 16 R03102; HS$TSHB_03; Binding factors: c-Jun , c-Jun BS , T3R , T3R-alpha , T3R-beta1 , T3R-beta BS , T3R-beta1 , T3R-alpha2 , T3R-alpha , BS T3R-beta2 , T3R-beta1 , T3R-beta2 . BS 17 34 R04771; HS$TSHB_04; Binding factors: T3R-beta1 . XX DR EMBL: M23981; HSTSHBA1. DR TRANSPATH: G000408. DR TRANSCOMPEL: C00138. DR LOCUSLINK: 7252. DR OMIM: 188540. DR REFSEQ: NM_000549. XX RN [1] RX MEDLINE; 95105146. RA Flynn T. R., Hollenberg A. N., Cohen O., Menke J. B., Usala S. J., RA Wondisford F. E. RT A novel C-terminal domain in the thyroid hormone receptor selectively RT mediates thyroid hormone inhibition RL J. Biol. Chem. 269:32713-32716 (1994). RN [2] RX MEDLINE; 93155090. RA Wondisford F. E., Steinfelder H. J., Nations M., Radovick S. RT AP-1 antagonizes thyroid hormone receptor action on the thyrotropin RT beta-subunit gene RL J. Biol. Chem. 268:2749-2754 (1993). RN [3] RX MEDLINE; 92063894. RA Yen P. M., Darling D. S., Chin W. W. RT Basal and thyroid hormone receptor auxiliary protein-enhanced binding of RT thyroid hormone receptor isoforms to native thyroid hormone response RT elements RL Endocrinology 129:3331-3336 (1991). RN [4] RX MEDLINE; 92042068. RA Bodenner D. L., Mroczynski M. A., Weintraub B. D., Radovick S., Wondisford RA F. E. RT A detailed functional and structural analysis of a major thyroid hormone RT inhibitory element in the human thyrotropin beta-subunit gene RL J. Biol. Chem. 266:21666-21673 (1991). RN [5] RX MEDLINE; 91195306. RA Steinfelder H. J., Hauser P., Nakayama Y., Radovick S., McClaskey J. H., RA Taylor T., Weintraub B. D., Wondisford F. E. RT Thyrotropin-releasing hormone regulation of human TSHB expression: Role of RT a pituitary-specific transcription factor (Pit-1/GHF-1) and potential RT interaction with a thyroid hormone-inhibitory element RL Proc. Natl. Acad. Sci. USA 88:3130-3134 (1991). XX // AC G000409 XX ID HS$MMP9 XX DT 14.06.1995 (created); dbo. DT 23.11.2001 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD MMP-9 XX DE matrix metalloproteinase 9 XX SY CLG4B; CLG4. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 20q12-q13 XX BC 6.1.4.7.3 XX DR TRANSPATH: G000409. DR TRANSCOMPEL: C00263. DR BRENDA: 3.4.24.24; Human. DR BRENDA: 3.4.24.35; Human. DR TRRD: 00019. DR LOCUSLINK: 4318. DR OMIM: 120361. DR REFSEQ: NM_004994. XX // AC G000410 XX ID HS$U1SN XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD U1 snRNA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.1.1 XX BS -229 -210 R02911; HS$U1SN_01; Binding factors: PSE1 . BS -64 -44 R02912; HS$U1SN_02; Binding factors: PSE1 . XX DR EMBL: J00318; HSUG1. DR TRANSPATH: G000410. XX RN [1] RX MEDLINE; 91009259. RA Knuth M. W., Gunderson S. I., Thompson N. E., Strasheim L. A., Burgess R. R. RT Purification and characterization of proximal sequence element-binding RT protein 1, a transcription activating protein related to Ku and TREF that RT binds the proximal sequence element of the human U1 promoter RL J. Biol. Chem. 265:17911-17920 (1990). XX // AC G000411 XX ID HS$U2SN XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD U2 snRNA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.1.2 XX BS -275 -203 R01496; HS$U2SN_02. BS -270 -259 R01497; HS$U2SN_03; Binding factors: Sp1 . BS -248 -238 R01498; HS$U2SN_04; Binding factors: Sp1 . BS -231 -222 R01499; HS$U2SN_05; Binding factors: Sp1 . BS -221 0 R01495; HS$U2SN_01. BS -221 -214 R01500; HS$U2SN_06; Binding factors: POU2F1 , BS Octa-factor . XX DR EMBL: K03023; HSUG2A. DR TRANSPATH: G000411. DR TRANSCOMPEL: C00039. DR TRRD: 00215. XX RN [1] RX MEDLINE; 89178656. RA Janson L., Weller P., Pettersson U. RT Nuclear Factor I can Functionally Replace Transcription Factor Sp1 in a U2 RT Small Nuclear RNA Gene Enhancer RL J. Mol. Biol. 205:387-396 (1989). RN [2] RX MEDLINE; 89091990. RA Baumruker T., Sturm R., Herr W. RT OBP100 binds remarkably degenerate octamer motifs through specific RT interactions with flanking sequences RL Genes Dev. 2:1400-1413 (1988). RN [3] RX MEDLINE; 87259982. RA Janson L., Bark C., Petterson U. RT Identification of proteins interacting with the enhancer of human U2 small RT nuclear RNA genes RL Nucleic Acids Res. 15:4997-5016 (1987). RN [4] RX MEDLINE; 86313585. RA Sive H. L., Roeder R. G. RT Interaction of a common factor with conserved promoter and enhancer RT sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) RT genes RL Proc. Natl. Acad. Sci. USA 83:6382-6386 (1986). XX // AC G000412 XX ID HS$U4CSN XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD U4C snRNA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.1.4 XX BS -247 -219 R01508; HS$U4CSN_01; Binding factors: CREB , NF-A BS . XX DR EMBL: M15957; HSUGU4CA. DR TRANSPATH: G000412. DR TRRD: 00216. XX RN [1] RX MEDLINE; 89091989. RA Weller P., Bark C., Janson L., Pettersson U. RT Transcription analysis of a human U4C gene: involvement of transcription RT factors novel to snRNA gene expression RL Genes Dev. 2:1389-1399 (1988). XX // AC G000413 XX ID HS$U6SN XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD U6 snRNA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.1.6 XX BS -46 0 R03171; HS$U6SN_01; Binding factors: TBP . XX DR EMBL: X07425; HSU6RNA. DR TRANSPATH: G000413. DR TRRD: 00131. XX RN [1] RX MEDLINE; 91331318. RA Lobo S. M., Lister J., Sullivan M. L., Hernandez N. RT The cloned RNA polymerase II transcription factor IID selects RNA RT polymerase III to transcribe the human U6 gene in vitro RL Genes Dev. 5:1477-1489 (1991). XX // AC G000414 XX ID HS$QP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD QP XX DE ubiquinone-binding protein XX SY QP-C; UQBP. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 8q22 XX BS -64 -54 R02670; HS$QP_01; Binding factors: NRF-1 , NRF-1 BS . XX DR EMBL: M35761; HSQBPC2. DR TRANSPATH: G000414. DR LOCUSLINK: 7381. DR OMIM: 191330. DR REFSEQ: NM_006294. XX RN [1] RX MEDLINE; 90346283. RA Evans M. J., Scarpulla R. C. RT NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal RT cells RL Genes Dev. 4:1023-1034 (1990). XX // AC G000415 XX ID HS$UPA XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD uPA XX DE urokinase-type plasminogen activator XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BC 6.1.4.7.1 XX BS -1989 -1964 R12088; HS$UPA_10; Binding factors: NERF-1a . BS -1976 -1970 R08492; HS$UPA_01; Binding factors: c-Ets-2 , PEA3 BS . BS -1969 -1960 R08493; HS$UPA_02; Binding factors: AP-1 , c-Jun BS , CRE-BP1 . BS -1951 -1941 R08495; HS$UPA_04; Binding factors: UEF-2 . BS -1950 -1920 R08497; HS$UPA_06; Binding factors: Pbx-1a , Pbx-1b BS , Pbx-1b , UEF-3 , Pbx-1a , PKNOX1 BS , PKNOX1 , Pbx-2 , Pbx-2 . BS -1948 -1939 R08500; HS$UPA_09; Binding factors: UEF-4 . BS -1942 -1934 R08496; HS$UPA_05; Binding factors: UEF-1 . BS -1924 -1914 R08498; HS$UPA_07; Binding factors: UEF-2 . BS -1915 -1907 R08499; HS$UPA_08; Binding factors: UEF-1 . BS -1886 -1878 R08494; HS$UPA_03; Binding factors: AP-1 , c-Fos BS , c-Jun , Fra-1 , JunB , JunD . XX DR EMBL: X12641; HSUPA5. DR TRANSPATH: G000415. DR TRANSCOMPEL: C00084. DR TRANSCOMPEL: C00085. DR TRANSCOMPEL: C00113. DR BRENDA: 3.4.21.73; Human. DR TRRD: 00218. XX RN [1] RX MEDLINE; 99384291. RA Cirillo G., Casalino L., Vallone D., Caracciolo A., De Cesare D., Verde P. RT Role of distinct mitogen-activated protein kinase pathways and cooperation RT between Ets-2, ATF-2, and Jun family members in human urokinase-type RT plasminogen activator gene induction by interleukin-1 and tetradecanoyl RT phorbol acetate RL Mol. Cell. Biol. 19:6340-6252 (1999). RN [2] RX MEDLINE; 99310664. RA Ferretti E., Schulz H., Talarico D., Blasi F., Berthelsen J. RT The PBX-regulating protein PREP1 is present in different PBX-complexed RT forms in mouse RL Mech. Dev. 83:53-64 (1999). RN [3] RX MEDLINE; 98151366. RA Berthelsen J., Zappavigna V., Mavilio F., Blasi F. RT Prep1, a novel functional partner of Pbx proteins RL EMBO J. 17:1423-1433 (1998). RN [4] RX MEDLINE; 97442465. RA De Cesare D., Palazzolo M., Berthelsen J., Blasi F. RT Characterization of UEF-4, a DNA-binding protein required for RT transcriptional synergism between two AP-1 sites in the human urokinase RT enhancer RL J. Biol. Chem. 272:23921-23929 (1997). RN [5] RX MEDLINE; 97152546. RA De Cesare D., Palazzolo M., Blasi F. RT Functional characterization of COM, a DNA region required for cooperation RT between AP-1 sites in urokinase gene transcription RL Oncogene 13:2551-2562 (1996). RN [6] RX MEDLINE; 96216491. RA Berthelsen J., Vandekerkhove J., Blasi F. RT Purification and characterization of UEF3, a novel factor involved in the RT regulation of the urokinase and other AP-1 controlled promoters RL J. Biol. Chem. 271:3822-3830 (1996). RN [7] RX MEDLINE; 96347578. RA Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T. A. RT Characterization of NERF, a novel transcription factor related to the Ets RT factor ELF-1 RL Mol. Cell. Biol. 16:5091-5106 (1996). RN [8] RX MEDLINE; 95352693. RA Lengyel E., Klostergaard J., Boyd D. RT Stimulation of urokinase expression by TNF-alpha requires the activation of RT binding sites for the AP-1 and PEA3 transcription factors RL Biochim. Biophys. Acta 1268:65-72 (1995). RN [9] RX MEDLINE; 95349959. RA De Cesare D., Vallone D., Caracciolo A., Sassone-Corsi P., Nerlov C., Verde RA P. RT Heterodimerization of c-Jun with ATF-2 and c-Fos is required for positive RT and negative regulation of the human urokinase enhancer RL Oncogene 11:365-376 (1995). RN [10] RX MEDLINE; 93049209. RA Nerlov C., De Cesare D., Pergola F., Caracciolo A., Blasi F., Johnsen M., RA Verde P. RT A regulatory element that mediates co-operation between a PEA3-Ap-1 element RT and an AP-1 site is required for phorbol ester induction of urokinase RT enhancer activity in HepG2 hepatoma cells RL EMBO J. 11:4573-4582 (1992). RN [11] RX MEDLINE; 92019827. RA Nerlov C., Rorth P., Blasi F., Johnsen M. RT Essential AP-1 and PEA3 binding elements in the human urokinase enhancer RT display cell type-specific activity RL Oncogene 6:1583-1592 (1991). XX // AC G000416 XX ID HS$VIMEN XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD VIM XX DE vimentin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 10p13 XX BC 6.1.2.6 XX BS -707 -685 R01564; HS$VIMEN_01; Binding factors: AP-1 , c-Jun BS . XX DR EMBL: M20028; HSVIM02. DR EMBL: X51907; HSVIM5RR. DR EMBL: M17888; HSVIMAA. DR TRANSPATH: G000416. DR LOCUSLINK: 7431. DR OMIM: 193060. DR REFSEQ: NM_003380. XX RN [1] RX MEDLINE; 89160319. RA Rittling S. R., Coutinho L., Amram T., Kolbe M. RT Ap-1/jun binding sites mediate serum inducibility of the human vimentin RT promoter RL Nucleic Acids Res. 17:1619 (1989). XX // AC G000417 XX ID HS$VIP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD VIP XX DE vasoactive intestinal polypeptide XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 6q24-q27 XX BC 6.1.5 XX BS -1292 -1279 R04473; HS$VIP_07. BS -1264 -1235 R04471; HS$VIP_05. BS -1215 -1190 R04472; HS$VIP_06. BS -89 -65 R01559; HS$VIP_01; Binding factors: c-Fos , c-Jun BS , CREB , CREB , CRE-BP1 . BS -88 -60 R01560; HS$VIP_02; Binding factors: CAP . BS -85 -70 R01561; HS$VIP_03. BS -84 -64 R01562; HS$VIP_04; Binding factors: ATF . XX DR EMBL: M11548; HSVIP1. DR EMBL: M33027; HSVIPAA. DR TRANSPATH: G000417. DR TRRD: 00217. DR LOCUSLINK: 7432. DR OMIM: 192320. DR REFSEQ: NM_003381. XX RN [1] RX MEDLINE; 95229620. RA Symes A. J., Rajan P., Corpus L., Fink J. S. RT C/EBP-related sites in addition to a Stat site are necessary for ciliary RT neurotrophic factor-leukemia inhibitory factor-dependent transcriptional RT activation by the vasoactivate intestinal peptide cytokine response element RL J. Biol. Chem. 270:8068-8075 (1995). RN [2] RX MEDLINE; 91139687. RA Fink J. S., Verhave M., Walton K., Mandel G., Goodman R. H. RT Cyclic AMP- and phorbol ester-induced transcriptional activation are RT mediated by the same enhancer element in the human vasoactive intestinal RT peptide gene RL J. Biol. Chem. 266:3882-3887 (1991). RN [3] RX MEDLINE; 90205810. RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H. RT A cDNA for a human cyclic AMP response element-binding protein which is RT distinct from CREB and expressed preferentially in brain RL Mol. Cell. Biol. 10:1347-1357 (1990). RN [4] RX MEDLINE; 91208099. RA Tassios P. T., La Thangue N. B. RT A multiplicity of differentiation-regulated ATF site-binding activities in RT embryonal carcinoma cells with distinct sequence and promoter specificities RL New Biol. 2:1123-1134 (1990). RN [5] RX MEDLINE; 89365161. RA Lin Y.-S., Green M. R. RT Similarities between prokaryotic and eukaryotic cyclic AMP-responsive RT promoter elements RL Nature 340:656-659 (1989). RN [6] RX MEDLINE; 89054030. RA Deutsch P. J., Hoeffler J. P., Jameson J. L., Lin J. C., Habener J. F. RT Structural determinants for transcriptional activation by cAMP-responsive RT DNA elements RL J. Biol. Chem. 263:18466-18472 (1988). RN [7] RX MEDLINE; 89039849. RA Hyman S. E., Comb M., Lin Y.-S., Pearlberg J., Green M. R., Goodman H. M. RT A Common trans-Acting Factor Is Involved in Transcriptional Regulation of RT Neurotransmitter Genes by Cyclic AMP RL Mol. Cell. Biol. 8:4225-4233 (1988). RN [8] RX MEDLINE; 88217908. RA Lin Y.-S., Green M. R. RT Interaction of a common cellular transcription factor, ATF, with regulatory RT elements in both E1a- and cyclic AMP-inducible promoters RL Proc. Natl. Acad. Sci. USA 85:3396-3400 (1988). RN [9] RX MEDLINE; 88320498. RA Fink J. S., Verhave M., Kasper S., Tsukada T., Mandel G., Goodman R. H. RT The CGTCA sequence motif is essential for biological activity of the RT vasoactive intestinal peptide gene cAMP-regulated enhancer RL Proc. Natl. Acad. Sci. USA 85:6662-6666 (1988). XX // AC G000418 XX ID HS$VLC1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD VLC1 XX DE ventricular myosin alkali light chain XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 3p XX BC 6.1.2.5.2 XX BS -107 -64 R02907; HS$VLC1_01; Binding factors: SRF , SRF (504 BS AA) . XX DR EMBL: M60511; HSVLC1. DR TRANSPATH: G000418. DR LOCUSLINK: 4634. DR OMIM: 160790. DR REFSEQ: NM_000258. XX RN [1] RX MEDLINE; 91035463. RA Kurabayashi M., Komuro I., Shibasaki Y., Tsuchimochi H., Takaku F., Yazaki RA Y. RT Functional identification of the transcriptional regulatory elements within RT the promoter region of the human ventricular myosin alkali light chain gene RL J. Biol. Chem. 265:19271-19278 (1990). XX // AC G000419 XX ID HS$ZG XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-Z XX DE zeta2-globin XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX CH 16p13.3 XX BC 6.1.3.10.2 XX BS -251 -233 R00565; HS$ZG_01; Binding factors: Sp1 . BS -236 -226 R00566; HS$ZG_02; Binding factors: GATA-1 . BS -221 -194 R00567; HS$ZG_03; Binding factors: ZF1 . BS -167 -146 R00568; HS$ZG_04; Binding factors: ZF2 . BS -116 -96 R00569; HS$ZG_05; Binding factors: GATA-1 , GATA-1 BS . BS -101 -68 R00570; HS$ZG_06; Binding factors: Sp1 . BS -87 -60 R00571; HS$ZG_07; Binding factors: CP2 . BS -75 -59 R00572; HS$ZG_08; Binding factors: CP1 . XX DR EMBL: J00182; HSHBA1. DR EMBL: U01317; HSHBB. DR TRANSPATH: G000419. DR TRRD: 00330. DR LOCUSLINK: 3050. DR OMIM: 142310. DR REFSEQ: NM_005332. XX RN [1] RX MEDLINE; 90097838. RA Yu C.-Y., Chen J., Lin L.-I., Tam M., Shen C.-K. J. RT Cell-type specific protein-DNA interactions in the human zeta-globin RT upstream promoter region: displacement of Sp1 by the erythroid RT cell-specific factor NF-E1 RL Mol. Cell. Biol. 10:282-294 (1990). RN [2] RX MEDLINE; 90221854. RA Watt P., Lamb P., Squire L., Proudfoot N. RT A factor binding GATAAG confers tissue specificity on the promoter of the RT human zeta-globin gene RL Nucleic Acids Res. 18:1339-1350 (1990). XX // AC G000420 XX ID HSMI$LSP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD LSP XX DE mitochondrial light strand promoter XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; primates XX BS empty empty R02998; HSMI$LSP_01. XX DR EMBL: M12531; MIHSPR. XX RN [1] RX MEDLINE; 91115851. RA Suzuki H., Hosokawa Y., Nishikimi M., Ozawa T. RT Existence of common homologous elements in the transcriptional regulatory RT regions of human nuclear genes abd mitochondrial gene for the oxidative RT phosphorylation system RL J. Biol. Chem. 266:2333-2338 (1991). XX // AC G000421 XX ID HSV$G38 XX DT 14.06.1995 (created); dbo. DT 10.12.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD G38 XX OS HSV, herpes simplex virus OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX BS -103 -16 R02851; HSV$G38_01; Binding factors: ICP4 . XX DR TRANSPATH: G000421. XX RN [1] RX MEDLINE; 91122047. RA Papavassiliou A. G., Wilcox K. W., Silverstein S. J. RT The interaction of ICP4 with cell/infected-cell factors and its state of RT phosphorylation modulate differential recognition of leader sequences in RT herpes simplex virus DNA RL EMBO J. 10:397-406 (1991). XX // AC G000422 XX ID HSV1$GD XX DT 14.06.1995 (created); dbo. DT 10.12.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD gD XX DE glycoprotein gD XX OS HSV-1, herpes simplex virus type 1 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX BS -109 -92 R02930; HSV1$GD_01; Binding factors: ICP4 . BS -96 -79 R02931; HSV1$GD_02; Binding factors: ICP4 . XX DR EMBL: X14112; HE1CG. DR EMBL: X02138; HEHSV1SU. DR TRANSPATH: G000422. XX RN [1] RX MEDLINE; 91187663. RA Pizer L. I., Everett R. D., Tedder D. G., Elliott M., Litman B. RT Nucleotides within both proximal and distal parts of the consensus sequence RT are important for a specific DNA recognition by the herpes simplex virus RT regulatory protein ICP4 RL Nucleic Acids Res. 19:477 (1991). XX // AC G000423 XX ID HSV1$ICP XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ICP42 XX DE internal cell protein 42 XX OS HSV-1, herpes simplex virus type 1 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX BC 6.3.4.1.1 XX BS -179 -94 R00783; HSV1$ICP_01; Binding factors: ICP4 . BS -78 -44 R00784; HSV1$ICP_02; Binding factors: ICP4 . BS 22 40 R00785; HSV1$ICP_03; Binding factors: ICP4 . BS 41 83 R00786; HSV1$ICP_04; Binding factors: ICP4 . XX DR TRANSPATH: G000423. XX RN [1] RX MEDLINE; 88178055. RA Michael N., Spector D., Mavromara-Nazos P., Kristie T. M., Roizman B. RT The DNA-binding properties of the major regulatory protein alpha4 of herpes RT simplex viruses RL Science 239:1531 (1988). XX // AC G000424 XX ID HSV1$IE1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IE-1 XX DE immediate early gene 1 XX OS HSV-1, herpes simplex virus type 1 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX BC 6.3.4.1.1 XX BS -171 -143 R00810; HSV1$IE1_01; Binding factors: POU2F1 , BS POU2F1a , POU2F2 (Oct-2.1) , Vmw65 , CCF , BS POU2F1b , POU2F1c . BS -167 -145 R01917; HSV1$IE1_03; Binding factors: POU2F1 , Vmw65 BS . BS -72 -46 R00811; HSV1$IE1_02; Binding factors: ICP4 . XX DR EMBL: X04614; HEHSV110. DR TRANSPATH: G000424. XX RN [1] RX MEDLINE; 91360357. RA Dent C. L., McIndoe G. A. J., Latchman D. S. RT The constitutively expressed octamer binding protein OTF-1 and a novel RT octamer binding protein expressed specifically in cervical cells bind to an RT octamer-related sequence in the human papillomavirus 16 enhancer RL Nucleic Acids Res. 19:4531-4535 (1991). RN [2] RX MEDLINE; 92020123. RA Everett R. D., Elliott M., Hope G., Orr A. RT Purification of the DNA binding domain of herpes simplex virus type 1 RT immediate-early protein Vmw175 as a homodimer and extensive mutagenesis of RT its DNA recognition site RL Nucleic Acids Res. 19:4901-4908 (1991). RN [3] RX MEDLINE; 90156555. RA Werstuck G., Bilan P., Capone J. P. RT Enhanced infectivity of herpes simplex virus type 1 viral DNA in a cell RT line expressing the trans-inducing factor Vmw65 RL J. Virol. 64:984-991 (1990). RN [4] RX MEDLINE; 90190844. RA Haigh A., Greaves R., O'Hare P. RT Interference with the assembly of a virus-host transcription complex by RT peptide competition RL Nature 344:257-259 (1990). RN [5] RX MEDLINE; 90174974. RA Wu C.-L., Wilcox K. W. RT Codons 262 to 490 from the herpes simplex virus ICP4 gene are sufficient to RT encode a sequence-specific DNA binding protein RL Nucleic Acids Res. 18:531-538 (1990). RN [6] RX MEDLINE; 91088259. RA Katan M., Haigh A., Verrijzer C. P., van der Vliet P. C., O'Hare P. RT Characterization of a cellular factor which interacts functionally with RT Oct-1 in the assembly of a multicomponent transcription complex RL Nucleic Acids Res. 18:6871-6880 (1990). RN [7] RX MEDLINE; 90076145. RA Kristie T. M., LeBovitz J. H., Sharp P. A. RT The octamer-binding proteins form multi-protein-DNA complexes with the HSV RT alphaTIF regulatory protein RL EMBO J. 8:4229-4238 (1989). RN [8] RX MEDLINE; 90015184. RA Stern S., Tanaka M., Herr W. RT The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with RT the HSV transactivator VP16 RL Nature 341:624-630 (1989). RN [9] RX MEDLINE; 88151048. RA O'Hare P., Goding C. R. RT Herpes Simplex Virus Regulatory Elements and the Immunoglobulin Octamer RT Domain Bind a Common Factor and Are Both Targets for Virion Transactivation RL Cell 52:435-445 (1988). RN [10] RX MEDLINE; 89070675. RA Scheidereit C., Cromlish J. A., Gerster T., Kawakami K., Balmaceda C.-G., RA Currie R. A., Roeder R. G. RT A human lymphoid-specific transcription factor that activates RT immunoglobulin genes is a homeobox protein RL Nature 336:551-557 (1988). RN [11] RX MEDLINE; 88320440. RA Gerster T., Roeder R. G. RT A herpesvirus trans-activating protein interacts with transcription factor RT OTF-1 and other cellular proteins RL Proc. Natl. Acad. Sci. USA 85:6347-6351 (1988). RN [12] RX MEDLINE; 87092399. RA Kristie T. M., Roizman B. RT Host cell proteins bind to the cis-acting site required for virion-mediated RT induction of herpes simplex virus 1 alpha genes RL Proc. Natl. Acad. Sci. USA 84:71-75 (1987). RN [13] RX MEDLINE; 88041050. RA McKnight J. L. C., Kristie T. M., Roizman B. RT Binding of the virion protein mediating alpha gene induction in herpes RT simplex virus 1-infected cells to its cis site requires cellular proteins RL Proc. Natl. Acad. Sci. USA 84:7061-7065 (1987). RN [14] RX MEDLINE; 86259665. RA Kristie T. M., Roizman B. RT DNA-binding site of major regulatory protein alpha4 specifically associated RT with promoter-regulatory domains of alpha genes of herpes simplex virus RT type 1 RL Proc. Natl. Acad. Sci. USA 83:4700-4704 (1986). XX // AC G000425 XX ID HSV1$IE2 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IE-2 XX DE immediate early gene 2 XX OS HSV-1, herpes simplex virus type 1 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX BC 6.3.4.1.1 XX BS -253 -86 R02732; HSV1$IE2_02; Binding factors: POU2F1 , NRD I BS . BS -253 -86 R02733; HSV1$IE2_03; Binding factors: POU2F1 , Vmw65 BS , alphaH0 . BS -182 -134 R00812; HSV1$IE2_01; Binding factors: alphaH2-alphaH3 BS , POU2F1 , Vmw65 . XX DR EMBL: X14112; HE1CG. DR TRANSPATH: G000425. XX RN [1] RX MEDLINE; 91251199. RA Spector D., Purves F., Roizman B. RT Role of alpha-transducing factor (VP16) in the induction of alpha genes RT within the context of viral genomes RL J. Virol. 65:3504-3513 (1991). RN [2] RX MEDLINE; 90319093. RA Spector D., Purves F., Roizman B. RT Mutational analysis of the promoter region of the alpha27 gene of herpes RT simplex virus 1 with the context of the viral genome RL Proc. Natl. Acad. Sci. USA 87:5268-5272 (1990). RN [3] RX MEDLINE; 87092399. RA Kristie T. M., Roizman B. RT Host cell proteins bind to the cis-acting site required for virion-mediated RT induction of herpes simplex virus 1 alpha genes RL Proc. Natl. Acad. Sci. USA 84:71-75 (1987). RN [4] RX MEDLINE; 88041050. RA McKnight J. L. C., Kristie T. M., Roizman B. RT Binding of the virion protein mediating alpha gene induction in herpes RT simplex virus 1-infected cells to its cis site requires cellular proteins RL Proc. Natl. Acad. Sci. USA 84:7061-7065 (1987). XX // AC G000426 XX ID HSV1$IE3 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IE-3 XX DE immediate early gene 3 XX OS HSV-1, herpes simplex virus type 1 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX BC 6.3.4.1.1 XX BS empty empty R01837; HSV1$IE3_11; Binding factors: GABP , IEFga BS . BS -330 -260 R00814; HSV1$IE3_02; Binding factors: POU2F1 , Vmw65 BS . BS -261 -252 R00815; HSV1$IE3_03; Binding factors: POU2F1 , POU2F1 BS , Vmw65 , Cx . BS -252 -235 R00816; HSV1$IE3_04; Binding factors: Sp1 . BS -224 -204 R00817; HSV1$IE3_05; Binding factors: Sp1 . BS -198 -178 R00818; HSV1$IE3_06; Binding factors: Sp1 . BS -155 -135 R00813; HSV1$IE3_01; Binding factors: ICP4 . BS -138 -120 R00819; HSV1$IE3_07; Binding factors: Sp1 . BS -117 -99 R00820; HSV1$IE3_08; Binding factors: POU2F1 , Vmw65 BS . BS -90 -71 R00821; HSV1$IE3_09; Binding factors: Sp1 . BS -9 20 R00822; HSV1$IE3_10; Binding factors: ICP4 . BS 1 0 R02017; HSV1$IE3_12; Binding factors: ICP4 . XX DR EMBL: J02218; HE1IE3A. DR EMBL: X06461; HEHSV1G3. DR TRANSPATH: G000426. XX RN [1] RX MEDLINE; 96347578. RA Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T. A. RT Characterization of NERF, a novel transcription factor related to the Ets RT factor ELF-1 RL Mol. Cell. Biol. 16:5091-5106 (1996). RN [2] RX MEDLINE; 95303615. RA Panagiotidis C. A., Artandi S., Calame K., Silverstein S. J. RT Polyamines alter sequence-specific DNA-protein interactions RL Nucleic Acids Res. 23:1800-1809 (1995). RN [3] RX MEDLINE; 91122047. RA Papavassiliou A. G., Wilcox K. W., Silverstein S. J. RT The interaction of ICP4 with cell/infected-cell factors and its state of RT phosphorylation modulate differential recognition of leader sequences in RT herpes simplex virus DNA RL EMBO J. 10:397-406 (1991). RN [4] RX MEDLINE; 92020123. RA Everett R. D., Elliott M., Hope G., Orr A. RT Purification of the DNA binding domain of herpes simplex virus type 1 RT immediate-early protein Vmw175 as a homodimer and extensive mutagenesis of RT its DNA recognition site RL Nucleic Acids Res. 19:4901-4908 (1991). RN [5] RX MEDLINE; 91343912. RA LaMarco K., Thompson C. C., Byers B. P., Walton E. M., McKnight S. L. RT Identification of Ets- and Notch-related subunits in GA binding proteins RL Science 253:789-792 (1991). RN [6] RX MEDLINE; 91343907. RA Thompson C. C., Brown T. A., McKnight S. L. RT Convergence of Ets- and Notch-related structural motifs in a heteromeric RT DNA binding complex RL Science 253:762-768 (1991). RN [7] RX MEDLINE; 91368568. RA Bovolenta C., Tognon M., Liboi E. RT Epidermal growth factor induces, in the ELalpha4-2 cell line, herpes RT simplex virus-1 alpha4 gene transcription in the absence of the viral RT trans-activator RL Virus Res. 19:199-208 (1991). RN [8] RX MEDLINE; 90356394. RA Everett R. D., Paterson T., Elliott M. RT The major transcriptional regulatory protein of herpes simplex virus type 1 RT includes a protease resistant DNA binding domain RL Nucleic Acids Res. 18:4579-4585 (1990). RN [9] RX MEDLINE; 90108686. RA LaMarco K. L., McKnight S. L. RT Purification of a set of cellular polypeptides that bind to the purine-rich RT cis-regulatory element of herpes simplex virus immediate early genes RL Genes Dev. 3:1372-1383 (1989). RN [10] RX MEDLINE; 88151048. RA O'Hare P., Goding C. R. RT Herpes Simplex Virus Regulatory Elements and the Immunoglobulin Octamer RT Domain Bind a Common Factor and Are Both Targets for Virion Transactivation RL Cell 52:435-445 (1988). RN [11] RX MEDLINE; 89091990. RA Baumruker T., Sturm R., Herr W. RT OBP100 binds remarkably degenerate octamer motifs through specific RT interactions with flanking sequences RL Genes Dev. 2:1400-1413 (1988). RN [12] RX MEDLINE; 89107993. RA Sturm R. A., Das G., Herr W. RT The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a RT homeo box subdomain RL Genes Dev. 2:1582-1599 (1988). RN [13] RX MEDLINE; 89070684. RA Sturm R. A., Herr W. RT The POU domain is a bipartite DNA-binding structure RL Nature 336:601-604 (1988). RN [14] RX MEDLINE; 88124254. RA Faber S. W., Wilcox K. W. RT Association of herpes simplex virus regulatory protein ICP4 with sequences RT spanning the ICP4 gene transcription initiation site RL Nucleic Acids Res. 16:555-570 (1988). RN [15] RX MEDLINE; 87092399. RA Kristie T. M., Roizman B. RT Host cell proteins bind to the cis-acting site required for virion-mediated RT induction of herpes simplex virus 1 alpha genes RL Proc. Natl. Acad. Sci. USA 84:71-75 (1987). RN [16] RX MEDLINE; 88041050. RA McKnight J. L. C., Kristie T. M., Roizman B. RT Binding of the virion protein mediating alpha gene induction in herpes RT simplex virus 1-infected cells to its cis site requires cellular proteins RL Proc. Natl. Acad. Sci. USA 84:7061-7065 (1987). RN [17] RX MEDLINE; 86259665. RA Kristie T. M., Roizman B. RT DNA-binding site of major regulatory protein alpha4 specifically associated RT with promoter-regulatory domains of alpha genes of herpes simplex virus RT type 1 RL Proc. Natl. Acad. Sci. USA 83:4700-4704 (1986). RN [18] RX MEDLINE; 85296380. RA Jones K. A., Tjian R. RT Sp1 binds to promoter sequences and activates herpes simplex virus RT 'immediate-early' gene transcription in vitro RL Nature 317:179-182 (1985). XX // AC G000427 XX ID HSV1$IE4 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IE-4/5 XX DE immediate early gene 4/5 XX OS HSV-1, herpes simplex virus type 1 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX BC 6.3.4.1.1 XX BS -377 -356 R00823; HSV1$IE4_01; Binding factors: Sp1 . BS -340 -325 R00824; HSV1$IE4_02; Binding factors: POU2F1 , Vmw65 BS . BS -230 0 R00825; HSV1$IE4_03; Binding factors: Sp1 . BS -35 0 R00826; HSV1$IE4_04; Binding factors: Sp1 . XX DR EMBL: J02220; HEHS1IEM5. DR TRANSPATH: G000427. XX RN [1] RX MEDLINE; 88151047. RA Preston C. M., Frame M. C., Campbell M. E. M. RT A Complex formed between Cell Components and an HSV Structural Polypeptide RT Binds to a Viral Immediate Early Gene Regulatory DNA Sequence RL Cell 52:425-434 (1988). RN [2] RX MEDLINE; 85296380. RA Jones K. A., Tjian R. RT Sp1 binds to promoter sequences and activates herpes simplex virus RT 'immediate-early' gene transcription in vitro RL Nature 317:179-182 (1985). XX // AC G000428 XX ID HSV1$ORI XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ori XX DE origin of replication XX OS HSV-1, herpes simplex virus type 1 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX BC 6.3.4.1.1 XX BS empty empty R03407; HSV1$ORI_01; Binding factors: OBP . XX DR EMBL: X14112; HE1CG. DR TRANSPATH: G000428. XX RN [1] RX MEDLINE; 91237795. RA Deb S., Deb S. P. RT A 269-amino-acid segment with a pseudo-leucine zipper and a RT helix-turn-helix motif codes for the sequence-specific DNA-binding domain RT of herpes simplex virus type 1 origin-binding protein RL J. Virol. 65:2829-2838 (1991). XX // AC G000429 XX ID HSV1$TK XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD tk XX DE thymidine kinase XX OS HSV-1, herpes simplex virus type 1 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX BC 6.3.4.1.1 XX BS -113 -91 R01442; HSV1$TK_01; Binding factors: Sp1 . BS -105 -95 R08860; HSV1$TK_13; Binding factors: E2F-1 . BS -96 -74 R01446; HSV1$TK_05; Binding factors: NF-Y' . BS -95 -67 R01445; HSV1$TK_04; Binding factors: C/EBPalpha . BS -90 -68 R01443; HSV1$TK_02; Binding factors: CP1 , CTF BS , NF-1 . BS -62 -42 R01444; HSV1$TK_03; Binding factors: Sp1 . BS -54 -39 R08861; HSV1$TK_14; Binding factors: E2F-1 . BS -51 -46 R01772; HSV1$TK_08; Binding factors: ZF5 . BS -21 -4 R04759; HSV1$TK_12; Binding factors: RAR-alpha1 , BS T3R-alpha . BS -3 12 R02721; HSV1$TK_09. BS -3 21 R02722; HSV1$TK_10; Binding factors: ICP4 . BS 2 42 R01695; HSV1$TK_06; Binding factors: ICP4 . BS 21 38 R08862; HSV1$TK_15; Binding factors: E2F-1 . BS 30 56 R02723; HSV1$TK_11; Binding factors: ICP4 . XX DR EMBL: X14112; HE1CG. DR EMBL: M15234; HEHS1TKP. DR EMBL: M25603; HEHSVTKRE. DR TRANSPATH: G000429. DR BRENDA: 2.7.1.21; Herpes_simplex_virus. XX RN [1] RX MEDLINE; 96218141. RA Shin E. K., Tevosian S. G., Yee A. S. RT The N-terminal region of E2F-1 is required for transcriptional activation RT of a new class of target promoter RL J. Biol. Chem. 271:12261-12268 (1996). RN [2] RX MEDLINE; 93361006. RA Au-Fliegner M., Helmer E., Casanova J., Raaka B. M., Samuels H. H. RT The conserved ninth c-terminal heptad in thyroid hormone and retinoic acid RT receptors mediates diverse responses by affecting heterodimer but not RT homodimer formation RL Mol. Cell. Biol. 13:5725-5737 (1993). RN [3] RX MEDLINE; 93170275. RA de Vack C., Lupp B., Kowenz-Leutz E., Schmid W., Schuetz G. RT Characterization of the nuclear proteins binding the CACCC element of a RT glucocorticoid-responive enhancer in the tyrosine aminotransferase gene RL Eur. J. Biochem. 211:459-465 (1993). RN [4] RX MEDLINE; 93376502. RA Numoto M., Niwa O., Kaplan J., Wong K. K., Merrell K., Kamiya K., RA Yanagihara K., Calame K. RT Transcriptional repressor ZF5 identifies a new conserved domain in zinc RT finger proteins RL Nucleic Acids Res. 21:3767-3775 (1993). RN [5] RX MEDLINE; 91122047. RA Papavassiliou A. G., Wilcox K. W., Silverstein S. J. RT The interaction of ICP4 with cell/infected-cell factors and its state of RT phosphorylation modulate differential recognition of leader sequences in RT herpes simplex virus DNA RL EMBO J. 10:397-406 (1991). RN [6] RX MEDLINE; 90110231. RA Papavassiliou A. G., Silverstein S. J. RT Characterization of DNA-Protein Complex Formation in Nuclear Extracts with RT a Sequence from the Herpes Simplex Virus Thymidine Kinase Gene RL J. Biol. Chem. 265:1648-1657 (1990). RN [7] RX MEDLINE; 90264439. RA Papavassiliou A. G., Silverstein S. J. RT Interaction of Cell and Virus Proteins with DNA Sequences Encompassing the RT Promoter/Regulatory and Leader Regions of the Herpes Simplex Virus RT Thymidine Kinase Gene RL J. Biol. Chem. 265:9402-9412 (1990). RN [8] RX MEDLINE; 89384647. RA Morgan W. D. RT Transcriptional Factor Sp1 Binds to and Activates a Human hsp70 Gene RT Promoter RL Mol. Cell. Biol. 9:4099-4104 (1989). RN [9] RX MEDLINE; 90098860. RA Ben-Hattar J., Beard P., Jiricny J. RT Cytosine methylation in CTF and Sp1 recognition sites of an HSV tk RT promoter: effects on transcription in vivo and on factor binding in vitro RL Nucleic Acids Res. 17:10179-10190 (1989). RN [10] RX MEDLINE; 87078403. RA Jones K. A., Kadonaga J. T., Rosenfeld P. J., Kelly T. J., Tjian R. RT A cellular DNA-binding protein that activates eukaryotic transcription and RT replication RL Cell 48:79-89 (1987). RN [11] RX MEDLINE; 87301730. RA Dorn A., Bollekens J., Staub A., Benoist C., Mathis D. RT A Multiplicity of CCAAT Box-Binding Proteins RL Cell 50:863-872 (1987). RN [12] RX MEDLINE; 86133549. RA Graves B. J., Johnson P. F., McKnight S. L. RT Homologous recognition of a promoter domain common to the MSV LTR and the RT HSV tk gene RL Cell 44:565-576 (1986). RN [13] RX MEDLINE; 85282613. RA Jones K. A., Yamamoto K. R., Tjian R. RT Two distinct transcription factors that bind to the HSV thymidine kinase RT promoter in vitro RL Cell 42:559-572 (1985). XX // AC G000430 XX ID HSV2$VMW65 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Vmw65 XX OS HSV-2, herpes simplex virus type 2 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX BC 6.3.4.1.1 XX BS -197 -111 R03991; HSV2$VMW65_02; Binding factors: Sp1 . BS -55 0 R03990; HSV2$VMW65_01; Binding factors: USF1 . XX DR EMBL: M75098; HEHSVVMW5. DR TRANSPATH: G000430. XX RN [1] RX MEDLINE; 92046332. RA Greaves R. F., O'Hare P. RT Sequence, function, and regulation of the Vmw65 gene of herpes simplex RT virus type 2 RL J. Virol. 65:6705-6713 (1991). XX // AC G000431 XX ID HT1$HTLV1 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HTLV-I XX DE human T-cell lymphotropic virus type I XX OS HTLV-I, human T-cell lymphotropic virus type I OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; mammalian type C OC oncoviruses XX BC 6.2.1.2 XX BS empty empty R03997; HT1$HTLV1_20; Binding factors: TAF-I , BS TAF-II , Tax . BS -252 -231 R00777; HT1$HTLV1_01; Binding factors: CREB , CREB BS , CRE-BP1 , TAF-I , TAF-II , Tax , BS TREB-1 , TREB-2 , TREB-3 , ATF-1 , CREB BS , ATF-1 , ATF3 , CREBbeta . BS -252 -232 R00778; HT1$HTLV1_02; Binding factors: TREB-1 . BS -250 -234 R02697; HT1$HTLV1_09; Binding factors: HEF-1T . BS -250 -218 R02698; HT1$HTLV1_10; Binding factors: AP-2alphaA , BS HEF-1B , AP-2alphaB . BS -243 -227 R02699; HT1$HTLV1_11; Binding factors: HEF-1B . BS -204 -183 R02700; HT1$HTLV1_12; Binding factors: HEF-1T . BS -203 -183 R00779; HT1$HTLV1_03; Binding factors: CREB , CREB BS , Tax , TREB-1 , ATF-1 , CREB , BS ATF3 , TxRE BP , CREBbeta . BS -202 -173 R02701; HT1$HTLV1_13; Binding factors: AP-2alphaA , BS HEF-1B , AP-2alphaB . BS -163 -117 R02069; HT1$HTLV1_07; Binding factors: Tax . BS -160 -117 R02099; HT1$HTLV1_08; Binding factors: c-Ets-1 68 . BS -155 -117 R09810; HT1$HTLV1_26; Binding factors: FOXN2 . BS -146 -129 R02704; HT1$HTLV1_16; Binding factors: Sp1 . BS -113 -92 R02702; HT1$HTLV1_14; Binding factors: AP-2alphaA , BS AP-2alphaB . BS -104 -84 R00780; HT1$HTLV1_04; Binding factors: CREB , Tax BS , TREB-1 , ATF-1 , CREMtaualpha . BS -103 -81 R02703; HT1$HTLV1_15; Binding factors: HEF-1T . BS -70 -50 R02705; HT1$HTLV1_17; Binding factors: NF-1 . BS -60 -41 R02706; HT1$HTLV1_18; Binding factors: HEF-4C . BS 181 334 R00781; HT1$HTLV1_05. BS 208 217 R00782; HT1$HTLV1_06. BS 228 246 R03155; HT1$HTLV1_19. BS 272 292 R04456; HT1$HTLV1_25; Binding factors: Sp1 , Tax BS , HEB1-p94 , HEB1-p67 . BS 329 349 R03999; HT1$HTLV1_21; Binding factors: c-Myb . BS 400 420 R04000; HT1$HTLV1_22; Binding factors: c-Myb . BS 583 602 R04001; HT1$HTLV1_23; Binding factors: c-Myb . BS 683 702 R04002; HT1$HTLV1_24; Binding factors: c-Myb . XX DR EMBL: M37299; HL1LTR. DR EMBL: M81248; HL1LV1A. DR EMBL: L10341; HTVGAGPO1. DR EMBL: J02029; RE1PROP. DR TRANSPATH: G000431. DR TRANSCOMPEL: C00007. DR TRRD: 00112. XX RN [1] RX MEDLINE; 96189099. RA Bantignies F., Rousset R., Desbois C., Jalinot P. RT Genetic characterization of transactivation of the human T-cell leukemia RT virus Type 1 promoter: binding of Tax to Tax-responsive element 1 is RT mediated by the cyclic AMP-responsive members of the CREB/ATF family of RT transcription factors RL Mol. Cell. Biol. 16:2174-2182 (1996). RN [2] RX MEDLINE; 94261642. RA Adya N., Zhao L.-J., Huang W., Boros I., Giam C.-Z. RT Expansion of CREB's DNA recognition specificity by Tax results from RT interaction with Ala-Ala-Arg at positions 282-284 near the conserved RT DNA-binding domain of CREB RL Proc. Natl. Acad. Sci. USA 91:5642-5646 (1994). RN [3] RX MEDLINE; 94088544. RA Paca-Uccaralertkun S., Zhao L.-J., Adya N., Cross J. V., Cullen B. R., RA Boros I. M., Giam C.-Z. RT In vitro selection of DNA elements highly responsive to the human T-cell RT lymphotropic virus type I transcriptional activator, Tax RL Mol. Cell. Biol. 14:456-462 (1994). RN [4] RX MEDLINE; 94023981. RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing RT dimerization RL Science 262:395-399 (1993). RN [5] RX MEDLINE; 93382766. RA Lombard-Platet G., Jalinot P. RT Purification by DNA affinity precipitation of the cellular factors HEB-p67 RT and HEB-p94 which bind specifically to the human T-cell leukemia virus RT type-I 21 bp enhancer RL Nucleic Acids Res. 21:3935-3942 (1993). RN [6] RX MEDLINE; 92085393. RA Dasgupta P., Reddy C. D., Saikumar P., Reddy E. P. RT The cellular proto-oncogene product Myb acts as transcriptional activator RT of the long terminal repeat of human T-lymphotropic virus type I RL J. Virol. 66:270-276 (1992). RN [7] RX MEDLINE; 92236572. RA Matthews M.-A. H., Markowitz R.-B., Dynan W. S. RT In vitro activation of transcription by the human T-cell leukemia virus RT type I Tax protein RL Mol. Cell. Biol. 12:1986-1996 (1992). RN [8] RX MEDLINE; 92302251. RA Aoyama N., Nagase T., Sawazaki T., Mizuguchi G., Nakagoshi H., Fujisawa RA J.-I., Yoshida M., Ishii S. RT Overlap of the p53-responsive element and cAMP-responsive element in the RT enhancer of human T-cell leukemia virus type I RL Proc. Natl. Acad. Sci. USA 89:5403-5407 (1992). RN [9] RX MEDLINE; 92331609. RA Muchardt C., Seeler J. S., Nirula A., Gong S., Gaynor R. RT Transcription factor AP-2 activates gene expression of HTLV-I RL EMBO J. 11:2573-2581 (1992). RN [10] RX MEDLINE; 92347862. RA Li C., Lusis A. J., Sparkes R., Tran S. M., Gaynor R. RT Characterization and chromosomal mapping of the gene encoding the cellular RT DNA binding protein HTLF RL Genomics 13:658-664 (1992). RN [11] RX MEDLINE; 92107967. RA Zhao L.-J., Giam C.-Z. RT Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) RT transcriptional activator Tax with cellular factors that bind specifically RT to the 21-base-pair repeats in the HTLV-I enhancer RL Proc. Natl. Acad. Sci. USA 88:11445-11449 (1991). RN [12] RX MEDLINE; 90183997. RA Montagne J., Beraud C., Crenon I., Lombard-Platet G., Gazzolo L., Sergeant RA A., Jalinot P. RT Tax1 induction of the HTLV-I 21 bp enhancer requires cooperation between RT two cellular DNA-binding proteins RL EMBO J. 9:957-964 (1990). RN [13] RX MEDLINE; 91006006. RA Bosselut R., Duvall J. F., Gegonne A., Bailly M., Hemar A., Brady J., RA Ghysdael J. RT The product of the c-ets-1 proto-oncogene and the related Ets2 protein act RT as transcriptional activators of the long terminal repeat of human T cell RT leukemia virus HTLV-1 RL EMBO J. 9:3137-3144 (1990). RN [14] RX MEDLINE; 90243705. RA Nyborg J. K., Dynan W. S. RT Interaction of Cellular Proteins with the Human T-cell Leukemia Virus Type RT I Transcriptional Control Region RL J. Biol. Chem. 265:8230-8236 (1990). RN [15] RX MEDLINE; 90243706. RA Nyborg J. K., Matthews M.-A. H., Yucel J., Walls L., Golde W. T., Dynan W. RA S., Wachsman W. RT Interaction of Host Cell Proteins with the Human T-cell Leukemia Virus Type RT I Transcriptional Control Region RL J. Biol. Chem. 265:8237-8242 (1990). RN [16] RX MEDLINE; 91056071. RA Xu Y.-L., Adya N., Siores E., Gao Q., Giam C.-Z. RT Cellular factors involved in transcription and Tax-mediated RT trans-activation directed by the TGACGT motifs in human T-cell leukemia RT virus type I promoter RL J. Biol. Chem. 265:20285-20292 (1990). RN [17] RX MEDLINE; 90156525. RA Poteat H. T., Chen F. Y., Kadison P., Sodroski J. G., Haseltine W. A. RT Protein Kinase A-dependent binding of a nuclear factor to the 21-base-pair RT repeat of the human T-cell leukemia virus type I long terminal repeat RL J. Virol. 64:1264-1270 (1990). RN [18] RX MEDLINE; 90318385. RA Marriott S. J., Lindholm P. F., Brown K. M., Gitlin S. D., Duvall J. F., RA Radonovich M. F., Brady J. N. RT A 36-Kilodalton Cellular Transcription Factor Mediates an Indirect RT Interaction of Human T-Cell Leukemia/Lymphoma Virus Type 1 TAX1 with a RT Responsive Element in the Viral Long Terminal Repeat RL Mol. Cell. Biol. 10:4192-4201 (1990). RN [19] RX MEDLINE; 89311609. RA Fujisawa J.-I., Toita M., Yoshida M. RT A unique enhancer element for the trans activator (p40tax) of human T-cell RT leukemia virus type I that is distinct from cyclic AMP- and RT 12-O-tetradecanoylphorbol-13-acetate-responsive elements RL J. Virol. 63:3234-3239 (1989). RN [20] RX MEDLINE; 89261803. RA Tan T.-H., Horikoshi M., Roeder R. G. RT Purification and Characterization of Multiple Nuclear Factors That Bind to RT the TAX-Inducible Enhancer within the Human T-Cell Leukemia Virus Long RT Terminal Repeat RL Mol. Cell. Biol. 9:1733-1745 (1989). RN [21] RX MEDLINE; 89345082. RA Nakamura M., Niki M., Ohtani K., Sugamura K. RT Differential activation of the 21-base-pair enhancer element of human RT T-cell leukemia virus type I by its own trans-activator and cyclic AMP RL Nucleic Acids Res. 17:5207 (1989). RN [22] RX MEDLINE; 87275939. RA Levinger L. F., Lautenberger J. A. RT Human protein binding to DNA sequences surrounding the human T-cell RT lymphotropic virus type-I long terminal repeat polyadenylation site RL Eur. J. Biochem. 166:519-526 (1987). XX // AC G000432 XX ID JCV$JCV XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD JCV XX DE polyoma JC virus XX OS JCV, JC polyoma virus OC viridae; ds-DNA nonenveloped viruses; papovaviridae; polyomaviruses XX BC 6.3.1.6 XX BS empty empty R02777; JCV$JCV_05; Binding factors: GF1 . BS empty empty R02778; JCV$JCV_06. BS empty empty R04852; JCV$JCV_04; Binding factors: Sp1 . BS 33 58 R00951; JCV$JCV_01; Binding factors: NF-1 . BS 131 156 R00952; JCV$JCV_02; Binding factors: NF-1 . BS 207 233 R00953; JCV$JCV_03; Binding factors: NF-1 . BS 240 0 R02833; JCV$JCV_07. XX DR EMBL: K02561; PAHEKA. DR EMBL: V01118; PAPOJC. DR EMBL: M21920; PAPPLY03. DR EMBL: M21921; PAPPLY04. DR EMBL: J02226; PAPPLYCG1. DR EMBL: M21919; PAPPLYJA. DR EMBL: M62922; PAPPLYPR. DR EMBL: S35561; S35561. DR EMBL: S41084; S41084. DR TRANSPATH: G000432. DR TRANSCOMPEL: C00146. XX RN [1] RX MEDLINE; 94117404. RA Henson J. W. RT Regulation of the glial-specific JC virus early promoter by the RT transcription factor Sp1 RL J. Biol. Chem. 269:1046-1050 (1994). RN [2] RX MEDLINE; 91340730. RA Kerr D., Khalili K. RT A recombinant cDNA derived from human brain encodes a DNA binding protein RT that stimulates transcription of the human neurotropic virus JCV RL J. Biol. Chem. 266:15876-15881 (1991). RN [3] RX MEDLINE; 90338009. RA Ahmed S., Rappaport J., Tada H., Kerr D., Khalili K. RT A nuclear protein derived from brain cells stimulates transcription of the RT human neurotropic virus promoter, JCVE, in vitro RL J. Biol. Chem. 265:13899-13905 (1990). RN [4] RX MEDLINE; 91178832. RA Major E. O., Ameniya K., Elder G., Houff S. A. RT Glial cells of the human developing brain and B cells of the immune system RT share a common DNA binding factor for recognition of the regulatroy RT sequences of the human polyomavirus, JCV RL J. Neurosci. Res. 27:461-471 (1990). RN [5] RX MEDLINE; 91081331. RA Ahmed S., Chowdhury M., Khalili K. RT Regulation of a human neurotropic virus promoter, JCVE:identification of a RT novel activator domain located upstream from the 98 bp enhancer promoter RT region RL Nucleic Acids Res. 18:7417 (1990). RN [6] RX MEDLINE; 89214124. RA Amemiya K., Traub R., Durham L., Major E. O. RT Interaction of a Nuclear Factor-1-like Protein with the Regulatory Region RT of Human Polyomavirus JC Virus RL J. Biol. Chem. 264:7025-7032 (1989). XX // AC G000433 XX ID KLULA$LAC12 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD LAC12 XX DE lactose permease XX OS yeast, Kluyveromyces lactis OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; OC Saccharomycetaceae; Kluyveromyces. XX BS -617 0 R04130; KLULA$LAC12_01; Binding factors: LAC9 . BS -337 0 R04131; KLULA$LAC12_02; Binding factors: LAC9 . XX DR EMBL: X06997; KLLAC12. DR TRANSPATH: G000433. DR BRENDA: 3.2.1.23; Kluyveromyces_lactis. XX RN [1] RX MEDLINE; 92020227. RA Goedecke A., Zachariae W., Arvanitidis A., Breunig K. D. RT Coregulation of the Kluyveromyces lactis lactose permease and RT beta-galactosidase genes is achieved by interaction of multiple LAC9 RT binding sites in a 2.6 kbp divergent promoter RL Nucleic Acids Res. 19:5351-5358 (1991). XX // AC G000434 XX ID KLULA$LAC4 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD LAC4 XX DE beta-galactosidase XX OS yeast, Kluyveromyces lactis OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; OC Saccharomycetaceae; Kluyveromyces. XX BS -665 0 R04129; KLULA$LAC4_02; Binding factors: LAC9 . BS -417 -409 R00962; KLULA$LAC4_01; Binding factors: LAC9 . XX DR EMBL: X00430; KLLAC4. DR TRANSPATH: G000434. DR BRENDA: 3.2.1.23; Kluyveromyces_lactis. XX RN [1] RX MEDLINE; 93233666. RA Zachariae W., Breunig D. RT Expression of the transcriptional activator LAC9 (K1GAL4) in Kluyveromyces RT lactis is controlled by autoregulation RL Mol. Cell. Biol. 13:3058-3066 (1993). RN [2] RX MEDLINE; 93181183. RA Zachariae W., Kuger P., Breunig K. D. RT Glucose repression of lactose/galactose metabolism in Kluyveromyces lactis RT is determined by the concentration of the transcriptional activator LA1C9 RT (K1GAL4) RL Nucleic Acids Res. 21:69-77 (1993). RN [3] RX MEDLINE; 92020227. RA Goedecke A., Zachariae W., Arvanitidis A., Breunig K. D. RT Coregulation of the Kluyveromyces lactis lactose permease and RT beta-galactosidase genes is achieved by interaction of multiple LAC9 RT binding sites in a 2.6 kbp divergent promoter RL Nucleic Acids Res. 19:5351-5358 (1991). RN [4] RX MEDLINE; 88142831. RA Breunig K. D., Kuger P. RT Functional Homology between the Yeast Regulatory Proteins GAL4 and LAC9: RT LAC9-Mediated Transcriptional Activation in Kluyveromyces lactis Involves RT Protein Binding to a Regulatory Sequence Homologous to the GAL4 RT Protein-Binding Site RL Mol. Cell. Biol. 7:4400-4406 (1987). XX // AC G000435 XX ID KLULA$LAC9 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD LAC9 XX DE lactose regulatory protein XX OS yeast, Kluyveromyces lactis OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; OC Saccharomycetaceae; Kluyveromyces. XX BS empty empty R03808; KLULA$LAC9_01. XX RN [1] RX MEDLINE; 93268314. RA Ganster R. W., Shen W., Schmidt M. C. RT Isolation of STD1, a high-copy-number suppressor of a dominant negative RT mutation in the yeast TATA-binding protein RL Mol. Cell. Biol. 13:3650-3659 (1993). XX // AC G000436 XX ID KLULA$REB1 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD REB1 XX OS yeast, Kluyveromyces lactis OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; OC Saccharomycetaceae; Kluyveromyces. XX BS -302 38 R03754; KLULA$REB1_01; Binding factors: REB1 , Reb1p BS . XX DR TRANSPATH: G000436. XX RN [1] RX MEDLINE; 93140755. RA Morrow B. E., Ju Q., Warner J. R. RT A bipartite DNA-binding domain in yeast Reb1p RL Mol. Cell. Biol. 13:1173-1182 (1993). XX // AC G000437 XX ID LP$LPS1B XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD LpS1beta XX OS sea urchin, Lytechinus pictus OC eukaryota; animalia; metazoa; echinodermata; echinozoa; echinoidea; OC echinacea; temnopleuroida; toxopneustidae XX BS -728 -721 R03631; LP$LPS1B_01. BS -76 -68 R03632; LP$LPS1B_02; Binding factors: IF1 . XX DR EMBL: M62848; LPLPS1B. DR TRANSPATH: G000437. XX RN [1] RX MEDLINE; 92249179. RA Xiang M., Lu S. Y., Musso M., Karsenty G., Klein W. H. RT A G-string positive cis-regulatory element in the LpS1 promoter binds two RT distinct nuclear factors distributed non-uniformly in Lytechinus pictus RT embryos RL Development 113:1345-1355 (1991). XX // AC G000438 XX ID LPV$LPV XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD LPV XX DE lymphotropic papova virus XX OS LPV, lymphotropic papova virus OC viridae; ds-DNA nonenveloped viruses; papovaviridae; papillomavirus XX BS empty empty R00971; LPV$LPV_01. BS 215 230 R01655; LPV$LPV_04. BS 243 273 R01654; LPV$LPV_03; Binding factors: Pu box binding factor BS . BS 248 273 R01653; LPV$LPV_02; Binding factors: Pu box binding factor BS (BJA-B) . XX DR EMBL: K02562; PALPVXX. DR TRANSPATH: G000438. XX RN [1] RX MEDLINE; 90204677. RA Erselius J. R., Jostes B., Hatzopoulos A. K., Mosthaf L., Gruss P. RT Cell-Type-Specific Control Elements of the Lymphotropic Papovavirus Enhancer RL J. Virol. 64:1657-1666 (1990). RN [2] RA Pettersson M., Schaffner W. RT A purine-rich DNA sequence motif present in SV40 and lymphotropic RT papovavirus binds a lymphoid-specific factor and contributes to enhancer RT activity in lymphoid cells RL Genes Dev. 1:962-972 (1987). RN [3] RX MEDLINE; 87133485. RA Schlokat U., Bohmann D., Schoeler H., Gruss P. RT Nuclear factors binding specific sequences within the immunoglobulin RT enhancer interact differentially with other enhancer elements RL EMBO J. 5:3251-3258 (1986). XX // AC G000439 XX ID MAIZE$ADH1P XX DT 14.06.1995 (created); dbo. DT 27.08.1999 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Adh1-PrF XX DE alcohol dehydrogenase 1, PrF allele XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.4.10 XX BS -190 -186 R00069; MAIZE$ADH1P_01. BS -145 -138 R00070; MAIZE$ADH1P_02. BS -120 -117 R00071; MAIZE$ADH1P_03. BS -108 -100 R00072; MAIZE$ADH1P_04. XX DR EMBL: K03285; ZMADH1P. DR BRENDA: 1.1.1.1; Zea_mays. XX RN [1] RX MEDLINE; 87250373. RA Ferl R. J., Nick H. S. RT In Vivo Detection of Regulatory Factor Binding Sites in the 5' Flanking RT Region of Maize Adh1 RL J. Biol. Chem. 262:7947-7950 (1987). XX // AC G000440 XX ID MAIZE$B32 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD alb b32 XX DE albumin b-32 XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.2 XX BS -210 -201 R02934; MAIZE$B32_01; Binding factors: Opaque-2 . BS -167 -158 R02935; MAIZE$B32_02; Binding factors: Opaque-2 . BS -143 -134 R02936; MAIZE$B32_03; Binding factors: Opaque-2 . BS -117 -108 R02937; MAIZE$B32_04; Binding factors: Opaque-2 . BS -68 -59 R02938; MAIZE$B32_05; Binding factors: Opaque-2 . XX DR TRANSPATH: G000440. XX RN [1] RX MEDLINE; 91160516. RA Lohmer S., Maddaloni M., Motto M., Di Fonzo N., Hartings H., Salamini F., RA Thompson R. D. RT The maize regulatory locus Opaque-2 encodes a DNA-binding protein which RT activates the transcription of the b-32 gene RL EMBO J. 10:617-624 (1991). XX // AC G000441 XX ID MAIZE$Z19AB XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD gZ19ab.1 XX DE alpha-zein XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX BS -129 52 R03640; MAIZE$Z19AB_01. XX RN [1] RX MEDLINE; 91355924. RA So J. S., Larkins B. A. RT Binding of an endosperm-specific nuclear protein to a maize beta-zein gene RT correlates with zein trancriptional acitivity RL Plant Mol. Biol. 17:309-319 (1991). XX // AC G000442 XX ID MAIZE$Z15A XX DT 14.06.1995 (created); dbo. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD gZ15A XX DE 14/15 kDa beta-zein XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX BS -83 -65 R08304; MAIZE$Z15A_02; Binding factors: Opaque-2 . BS -69 -46 R03639; MAIZE$Z15A_01; Binding factors: beta-1 . XX DR EMBL: M12147; ZMZE15A3. DR EMBL: M13507; ZMZE15G. DR EMBL: M72708; ZMZEINP. DR TRANSPATH: G000442. XX RN [1] RX MEDLINE; 95284338. RA Cord Neto G., Yunes J. A., da Silva M. J., Vettore A. L., Arruda P., Leite RA A. RT The involvement of Opaque 2 on beta-prolamin gene regulation in maize and RT Coix suggests a more general role for this transcriptional activator. RL Plant Mol. Biol. 27:1015-1029 (1995). RN [2] RX MEDLINE; 91355924. RA So J. S., Larkins B. A. RT Binding of an endosperm-specific nuclear protein to a maize beta-zein gene RT correlates with zein trancriptional acitivity RL Plant Mol. Biol. 17:309-319 (1991). XX // AC G000443 XX ID MAIZE$PEPC XX DT 14.06.1995 (created); dbo. DT 29.04.1999 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD C4PEPC XX DE C4-type phosphoenolpyruvate carboxylase XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.4 XX BS -884 -847 R03628; MAIZE$PEPC_01; Binding factors: MNF1 , MNB1b BS . BS -774 -765 R08279; MAIZE$PEPC_02; Binding factors: MNB1a , Dof2 BS . BS -674 -664 R08280; MAIZE$PEPC_03; Binding factors: MNB1a , Dof2 BS . BS -298 -289 R08281; MAIZE$PEPC_04; Binding factors: MNB1a , Dof2 BS . BS -169 -160 R08282; MAIZE$PEPC_05; Binding factors: MNB1a , Dof2 BS . BS -106 -97 R08283; MAIZE$PEPC_06; Binding factors: MNB1a , Dof2 BS . XX DR EMBL: X14579; ZMPC324. DR EMBL: X15642; ZMPEP. DR TRANSPATH: G000443. DR BRENDA: 4.1.1.31; Zea_mays. XX RN [1] RX MEDLINE; 98138060. RA Yanagisawa S., Sheen J. RT Involvement of maize Dof zinc finger proteins in tissue-specific and RT light-regulated gene expression RL Plant Cell 10:75-89 (1998). RN [2] RX MEDLINE; 93340215. RA Yanagisawa S., Izui K. RT Molecular cloning of two DNA-binding proteins of maize that are RT structurally different but interact with the same sequence motif RL J. Biol. Chem. 268:16028-16036 (1993). RN [3] RX MEDLINE; 90186704. RA Yanagisawa S., Izui K. RT Maize phosphoenolpyruvate carboxylase involved in C4 photosynthesis RL J. Biochem. 106:982-987 (1989). XX // AC G000444 XX ID MAIZE$SHR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Sh XX DE Shrunken XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BS -302 45 R09794; MAIZE$SHR_04; Binding factors: ZmHox2a , BS ZmHox2b . BS -47 -37 R02476; MAIZE$SHR_03; Binding factors: ZmHox1a . BS -39 -30 R02475; MAIZE$SHR_02; Binding factors: ZmHox1a . BS -17 -7 R02474; MAIZE$SHR_01; Binding factors: ZmHox1a . XX DR TRANSPATH: G000444. XX RN [1] RX MEDLINE; 96189260. RA Klinge B., Uberlacker B., Korfhage C., Werr W. RT ZmHox: a novel class of maize homeobox genes RL Plant Mol. Biol. 30:439-453 (1996). RN [2] RX MEDLINE; 92371444. RA Bellmann R., Werr W. RT Zmhox 1a, the product of a novel maize homeobox gene, interacts with the RT Shrunken 26bf feedback control element RL EMBO J. 11:3367-3374 (1992). XX // AC G000445 XX ID MAIZE$22Z1 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD 22Z-1 XX DE zein storage protein 22Z-1 XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX BS -800 0 R03024; MAIZE$22Z1_02; Binding factors: Opaque-2 . BS -316 -281 R02297; MAIZE$22Z1_01; Binding factors: Opaque-2 . XX DR EMBL: X55722; ZMC1ZEIN. DR TRANSPATH: G000445. XX RN [1] RX MEDLINE; 93005718. RA Schmidt R. J., Ketudat M., Aukerman M. J., Hoschek G. RT Opaque-2 is a transcriptional activator that recognizes a specific target RT site in 22-kD zein genes RL Plant Cell 4:689-700 (1992). RN [2] RX MEDLINE; 91138964. RA Aukerman M. J., Schmidt R. J., Burr B., Burr F. A. RT An arginine to lysine substitution in the bZIP domain of an opaque-2 mutant RT in maize abolishes specific DNA binding RL Genes Dev. 5:310-320 (1991). XX // AC G000446 XX ID MAIZE$22Z2 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD 22Z-2 XX DE zein storage protein 22Z-2 XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX BS -305 -288 R02296; MAIZE$22Z2_01; Binding factors: Opaque-2 . XX DR EMBL: X55723; ZMC2ZEIN. DR TRANSPATH: G000446. XX RN [1] RX MEDLINE; 93005718. RA Schmidt R. J., Ketudat M., Aukerman M. J., Hoschek G. RT Opaque-2 is a transcriptional activator that recognizes a specific target RT site in 22-kD zein genes RL Plant Cell 4:689-700 (1992). RN [2] RX MEDLINE; 91138964. RA Aukerman M. J., Schmidt R. J., Burr B., Burr F. A. RT An arginine to lysine substitution in the bZIP domain of an opaque-2 mutant RT in maize abolishes specific DNA binding RL Genes Dev. 5:310-320 (1991). XX // AC G000447 XX ID MAIZE$22Z3 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD 22Z-3 XX DE zein storage protein 22Z-3 XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX BS -312 -276 R02298; MAIZE$22Z3_01; Binding factors: Opaque-2 . XX DR EMBL: X55726; ZMC3ZEIN. DR TRANSPATH: G000447. XX RN [1] RX MEDLINE; 93005718. RA Schmidt R. J., Ketudat M., Aukerman M. J., Hoschek G. RT Opaque-2 is a transcriptional activator that recognizes a specific target RT site in 22-kD zein genes RL Plant Cell 4:689-700 (1992). XX // AC G000448 XX ID MAIZE$22Z4 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD 22Z-4 XX DE zein storage protein 22Z-4 XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX BS -336 -312 R08284; MAIZE$22Z4_02; Binding factors: PBF . BS -310 -274 R02299; MAIZE$22Z4_01; Binding factors: Opaque-2 , BS OHP1 . XX DR EMBL: X55724; ZMC4ZEIN. DR EMBL: M86591; ZMZEINA. DR TRANSPATH: G000448. XX RN [1] RX MEDLINE; 99077855. RA Wang Z., Messing J. RT Modulation of gene expression by DNA-protein and protein-protein RT interactions in the promoter region of the zein multigene family RL Gene 223:333-345 (1998). RN [2] RX MEDLINE; 97352860. RA Vicente-Carbajosa J., Moose S. P., Parsons R. L., Schmidt R. J. RT A maize zinc-finger protein binds the prolamin box in zein gene promoters RT and interacts with the basic leucine zipper transcriptional activator RT Opaque2 RL Proc. Natl. Acad. Sci. USA 94:7685-7690 (1997). RN [3] RX MEDLINE; 93200807. RA Pysh L. D., Aukerman M. J., Schmidt R. J. RT OHP1: a maize basic domain/leucine zipper protein that interacts with RT opaque2 RL Plant Cell 5:227-236 (1993). RN [4] RX MEDLINE; 93005718. RA Schmidt R. J., Ketudat M., Aukerman M. J., Hoschek G. RT Opaque-2 is a transcriptional activator that recognizes a specific target RT site in 22-kD zein genes RL Plant Cell 4:689-700 (1992). XX // AC G000449 XX ID MAIZE$PML1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD pML1 XX DE zein storage protein pML1 XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX // AC G000450 XX ID MAIZE$PML2 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD pML2 XX DE zein storage protein pML2 XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX // AC G000451 XX ID MAIZE$PMS1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD pMS1 XX DE zein storage protein pMS1 XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX BS -141 -126 R01603; MAIZE$PMS1_01. BS -86 -78 R01604; MAIZE$PMS1_02. XX RN [1] RX MEDLINE; 90170908. RA Grasser K. D., Maier U.-G., Haass M. M., Feix G. RT Maize High Mobility Group Proteins Bind to CCAAT and TATA Boxes of a Zein RT Gene Promoter RL J. Biol. Chem. 265:4185-4188 (1990). XX // AC G000452 XX ID MAIZE$Z7 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Z7 XX DE zein storage protein Z7 XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX // AC G000453 XX ID MAIZE$ZA1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD zA1 XX DE zein storage protein zA1 XX OS maize, Zea mays OC eukaryota; viridiplantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX BC 1.1.3.1 XX BS -301 -284 R02303; MAIZE$ZA1_01; Binding factors: Opaque-2 . XX DR TRANSPATH: G000453. XX RN [1] RX MEDLINE; 93005718. RA Schmidt R. J., Ketudat M., Aukerman M. J., Hoschek G. RT Opaque-2 is a transcriptional activator that recognizes a specific target RT site in 22-kD zein genes RL Plant Cell 4:689-700 (1992). XX // AC G000454 XX ID MASV$RPE1 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD rpe1 XX DE rightward promoter XX OS MSV, maize streak virus OC viridae; ss-DNA nonenveloped viruses; geminiviridae XX BS 2481 2521 R03672; MASV$RPE1_01. XX DR EMBL: X01633; GEMSV01. XX RN [1] RX MEDLINE; 91355911. RA Fenoll C., Schwarz J. J., Black D. M., Schneider M., Howell S. H. RT The intergenic region of maize streak virus contains a GC-rich element that RT activates rightward transcription and binds maize nuclear factors RL Plant Mol. Biol. 15:865-877 (1990). XX // AC G000455 XX ID MMTV$MMTV XX DT 14.06.1995 (created); dbo. DT 11.12.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD MMTV XX DE mouse mammary tumor virus XX OS MMTV, mouse mammary tumor virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; mammalian type C OC oncoviruses XX BC 6.2.1.2 XX BS -1075 -1055 R03110; MMTV$MMTV_38; Binding factors: MP4 . BS -1048 -1021 R04187; MMTV$MMTV_43; Binding factors: NF-1 . BS -1024 -1012 R08502; MMTV$MMTV_48; Binding factors: AP-2alpha , BS AP-2alphaA . BS -1010 -987 R04188; MMTV$MMTV_44; Binding factors: MAF . BS -943 -919 R04189; MMTV$MMTV_45. BS -917 -902 R04190; MMTV$MMTV_46. BS -901 -872 R03111; MMTV$MMTV_39; Binding factors: NF-1 , MAF BS . BS -784 -762 R04191; MMTV$MMTV_47. BS -776 -737 R02454; MMTV$MMTV_36; Binding factors: c-Fos , c-Jun BS . BS -485 -415 R03112; MMTV$MMTV_40. BS -427 -418 R03541; MMTV$MMTV_41. BS -393 -376 R03542; MMTV$MMTV_42. BS -305 -289 R01099; MMTV$MMTV_01; Binding factors: GR . BS -283 -269 R01100; MMTV$MMTV_02; Binding factors: GR . BS -221 107 R02961; MMTV$MMTV_37; Binding factors: GR . BS -216 -79 R01101; MMTV$MMTV_03; Binding factors: AR , GR BS . BS -197 -160 R01102; MMTV$MMTV_04; Binding factors: GR , PR B BS . BS -195 -166 R01103; MMTV$MMTV_05; Binding factors: GR . BS -192 -163 R01104; MMTV$MMTV_06; Binding factors: GR , GR BS , PR B . BS -189 -166 R01109; MMTV$MMTV_11; Binding factors: GR . BS -189 -162 R01110; MMTV$MMTV_12; Binding factors: PR B , PR A BS . BS -185 -175 R01111; MMTV$MMTV_13. BS -180 -171 R01112; MMTV$MMTV_14; Binding factors: PR B . BS -166 -149 R01113; MMTV$MMTV_15. BS -162 -142 R01114; MMTV$MMTV_16; Binding factors: GR . BS -159 -135 R01115; MMTV$MMTV_17; Binding factors: GR . BS -140 -115 R01116; MMTV$MMTV_18. BS -138 -72 R01117; MMTV$MMTV_19; Binding factors: GR , PR B BS . BS -132 -71 R01118; MMTV$MMTV_20; Binding factors: PR B . BS -127 -84 R01119; MMTV$MMTV_21; Binding factors: GR . BS -125 -105 R01120; MMTV$MMTV_22; Binding factors: PR B , PR B BS , PR A . BS -124 -71 R01121; MMTV$MMTV_23; Binding factors: GR . BS -123 -94 R09957; MMTV$MMTV_49; Binding factors: RXR-alpha , BS LXR-alpha , SXR . BS -105 0 R01106; MMTV$MMTV_08; Binding factors: GR , PR B BS . BS -105 -71 R01122; MMTV$MMTV_24; Binding factors: PR B , PR A BS . BS -100 -93 R01123; MMTV$MMTV_25; Binding factors: PR B . BS -86 0 R01107; MMTV$MMTV_09; Binding factors: GR , PR B BS . BS -83 -74 R01124; MMTV$MMTV_26; Binding factors: PR B . BS -83 -55 R01125; MMTV$MMTV_27; Binding factors: NF-1 . BS -82 -55 R01126; MMTV$MMTV_28; Binding factors: NF-1 , NF-1 BS , NF-1 , TGGCA-binding protein . BS -82 12 R01127; MMTV$MMTV_29; Binding factors: factor i , NF-1 BS . BS -71 0 R01108; MMTV$MMTV_10; Binding factors: GR , PR B BS . BS -47 -20 R01128; MMTV$MMTV_30; Binding factors: factor i . BS -42 -4 R01129; MMTV$MMTV_31; Binding factors: factor i . BS 113 143 R01130; MMTV$MMTV_32; Binding factors: GR . BS 242 271 R01131; MMTV$MMTV_33; Binding factors: GR . BS 1145 1167 R01132; MMTV$MMTV_34; Binding factors: GR . BS 1172 1193 R01133; MMTV$MMTV_35; Binding factors: GR . XX DR EMBL: M11024; MMERMMTR. DR EMBL: V01175; REMM01. DR EMBL: M15122; REMMTPRO. DR EMBL: X12376; REMMTVSR. DR EMBL: K01044; REPRGR1. DR EMBL: S75270; S75270. DR TRANSPATH: G000455. DR TRANSCOMPEL: C00002. DR TRANSCOMPEL: C00043. DR TRRD: 00045. XX RN [1] RX MEDLINE; 99003072. RA Blumberg B., Sabbagh W J. r., Juguilon H., Bolado J J. r., van Meter C. M., RA Ong E. S., Evans R. M. RT SXR, a novel steroid and xenobiotic-sensing nuclear receptor RL Genes Dev. 12:3195-3205 (1998). RN [2] RX MEDLINE; 95262897. RA Willy P. J., Umesono K., Ong E. S., Evans R. M., Heyman R. A., Mangelsdorf RA D. J. RT LXR, a nuclear receptor that defines a distinct retinoid response pathway RL Genes Dev. 9:1033-1045 (1995). RN [3] RX MEDLINE; 95081159. RA Mellentin-Michelotti J., John S., Pennie W. D., Williams T., Hager G. L. RT The 5' enhancer of the mouse mammary tumor virus long terminal repeat RT contains a functional AP-2 element RL J. Biol. Chem. 269:31983-31990 (1994). RN [4] RX MEDLINE; 93002533. RA Truss M., Chalepakis G., Beato M. RT Interplay of steroid hormone receptors and transcription factors on the RT mouse mammary tumor virus promoter RL J. Steroid Biochem. Mol. Biol. 43:365-378 (1992). RN [5] RX MEDLINE; 92237273. RA Perlmann T. RT Glucocorticoid receptor DNA-binding specificity is increased by the RT organization of DNA in nucleosomes RL Proc. Natl. Acad. Sci. USA 89:3884-3888 (1992). RN [6] RX MEDLINE; 92196588. RA Archer T. K., Lefebvre P., Wolford R. G., Hager G. L. RT Transcription factor loading on the MMTV promoter: a bimodal mechanism for RT promoter activation RL Science 255:1573-1576 (1992). RN [7] RX MEDLINE; 93024436. RA Mink S., Haertig E., Jennewein P., Doppler W., Cato A. C. B. RT A mammary cell-specific enhancer in mouse mammary tumor virus DNA is RT composed of multiple regulatory elements including binding sites for RT CTF/NFI and a novel transcription factor, mammary cell-activating factor RL Mol. Cell. Biol. 12:4906-4918 (1992). RN [8] RX MEDLINE; 91139625. RA de Vos P., Claessens F., Winderickx J., van Dijck P., Celis L., Peeters B., RA Rombauts W., Heyns W., Verhoeven G. RT Interaction of androgen response elements with the DNA-binding domain of RT the rat androgen receptor expressed in Escherichia coli RL J. Biol. Chem. 266:3439-3443 (1991). RN [9] RX MEDLINE; 92084718. RA Lee J. W., Moffitt P. G., Morley K. L., Peterson D. O. RT Multipartite structure of a negative regulatory element associated with a RT steroid hormone-inducible promoter RL J. Biol. Chem. 266:24101-24108 (1991). RN [10] RX MEDLINE; 91117234. RA Archer T. K., Cordingley M. G., Wolford R. G., Hager G. L. RT Transcription factor access is mediated by accurately positioned RT nucleosomes on the mouse mammary tumor virus promoter RL Mol. Cell. Biol. 11:688-698 (1991). RN [11] RX MEDLINE; 91203873. RA Lefebvre P., Berard D. S., Cordingley M. G., Hager G. L. RT Two regions of the mouse mammary tumor virus long terminal repeat regulate RT the activity of its promoter in mammary cell lines RL Mol. Cell. Biol. 11:2529-2537 (1991). RN [12] RX MEDLINE; 91025066. RA Siddique H. R., Sarkar N. H. RT The interaction of a c-jun/fos related protein factor with the U3 sequences RT of the mouse mammary tumor virus LTR RL Biochem. Biophys. Res. Commun. 172:348 (1990). RN [13] RX MEDLINE; 90182662. RA Pina B., Brueggemeier U., Beato M. RT Nucleosome Positioning Modulates Accessibility of Regulatory Proteins to RT the Mouse Mammary Tumor Virus Promoter RL Cell 60:719-731 (1990). RN [14] RX MEDLINE; 90174951. RA Courtois S. J., Lafontaine D. A., Lemaigre F. P., Durviaux S. M., Rousseau RA G. G. RT Nuclear factor-I and activator protein-2 bind in a mutually exclusive way RT to overlapping promoter sequences and trans-activate the human growth RT hormone gene RL Nucleic Acids Res. 18:57-64 (1990). RN [15] RX MEDLINE; 90291988. RA Brueggemeier U., Rogge L., Winnacker E.-L., Beato M. RT Nuclear factor I acts as a transcription factor on the MMTV promoter but RT competes with steroid hormone receptors for DNA binding RL EMBO J. 9:2233-2239 (1990). RN [16] RX MEDLINE; 90154018. RA Eriksson P., Wrange Oe. RT Protein-protein contacts in the glucocorticoid receptor homodimer influence RT its DNA binding properties RL J. Biol. Chem. 265:3535-3542 (1990). RN [17] RX MEDLINE; 91009155. RA Perlmann T., Eriksson P., Wrange Oe. RT Quantitative analysis of the glucocorticoid receptor-DNA interaction at the RT mouse mammary tumor virus glucocorticoid response element RL J. Biol. Chem. 265:17222-17229 (1990). RN [18] RX MEDLINE; 90384971. RA Truss M., Chalepakis G., Beato M. RT Contacts between steroid hormone receptors and thymines in DNA: An RT interference method RL Proc. Natl. Acad. Sci. USA 87:7180-7184 (1990). RN [19] RX MEDLINE; 89231640. RA Eul J., Meyer M. E., Tora L., Bocquel M. T., Quirin-Stricker C., Chambon RA P., Gronemeyer H. RT Expression of active hormone and DNA-binding domains of the chicken RT progesterone receptor in E. coli RL EMBO J. 8:83-90 (1989). RN [20] RX MEDLINE; 89174816. RA Wrange O., Eriksson P., Perlmann T. RT The Purified Activated Glucocorticoid Receptor Is a Homodimer RL J. Biol. Chem. 264:5253-5259 (1989). RN [21] RX MEDLINE; 89384628. RA Gowland P. L., Buetti E. RT Mutations in the Hormone Regulatory Element of Mouse Mammary Tumor Virus RT Differentially Affect the Response to Progestins, Androgens, and RT Glucocorticoids RL Mol. Cell. Biol. 9:3999-4008 (1989). RN [22] RX MEDLINE; 89263718. RA Buetti E., Kuehnel B., Diggelmann H. RT Dual function of a nuclear factor I binding site in MMTV transcription RT regulation RL Nucleic Acids Res. 17:3065-3078 (1989). RN [23] RX MEDLINE; 90045474. RA Strawhecker J. M., Betz N. A., Neades R. Y., Houser W., Pelling J. C. RT Binding of the 97 kDa glucocorticoid receptor to the 5'-upstream flanking RT region of the mouse c-Ha-ras oncogene RL Oncogene 4:1317-1322 (1989). RN [24] RX MEDLINE; 89145196. RA Schauer M., Chalepakis G., Willmann T., Beato M. RT Binding of hormone accelerates the kinetics of glucocorticoid and RT progesterone receptor binding to DNA RL Proc. Natl. Acad. Sci. USA 86:1123-1127 (1989). RN [25] RX MEDLINE; 89317479. RA Freedman L. P., Yoshinaga S. K., Vanderbilt J. N., Yamamoto K. RT In vitro transcription enhancement by purified derivates of the RT glucocorticoid receptor RL Science 245:298-301 (1989). RN [26] RX MEDLINE; 88210462. RA Chalepakis G., Arnemann J., Slater E., Brueller H.-J., Gross B., Beato M. RT Differential Gene Activation by Glucocorticoids and Progestins through the RT Hormone Regulatory Element of Mouse Mammary Tumor Virus RL Cell 53:371-382 (1988). RN [27] RX MEDLINE; 89030601. RA Perlmann T., Wrange Oe. RT Specific glucocorticoid receptor binding to DNA reconstituted in a RT nucleosome RL EMBO J. 7:3073-3079 (1988). RN [28] RX MEDLINE; 89030601. RA Perlmann T., Wrange Oe. RT Specific glucocorticoid receptor binding to DNA reconstituted in a RT nucleosome RL EMBO J. 7:3073-3079 (1988). RN [29] RX MEDLINE; 88312588. RA Cato A. C. B., Skroch P., Weinmann J., Butkeraitis P., Ponta H. RT DNA sequences outside the receptor-binding sites differentially modulate RT the responsiveness of the mouse mammary tumor virus to various steroid RT hormones RL EMBO J. 7:1403-1410 (1988). RN [30] RX MEDLINE; 89127229. RA Langer S. J., Ostrowski M. C. RT Negative Regulation of Transcription In Vitro by a Glucocorticoid Response RT Element Is Mediated by a trans-Acting Factor RL Mol. Cell. Biol. 8:3872-3881 (1988). RN [31] RX MEDLINE; 89070707. RA Guiochon-Mantel A., Loosfelt H., Ragot T., Bailly A., Atger M., Misrahi M., RA Perricaudet M., Milgrom E. RT Receptors bound to antiprogestin form abortive complexes with hormone RT responsive elements RL Nature 336:695-698 (1988). RN [32] RX MEDLINE; 89057461. RA Chalepakis G., Postma J. P. M., Beato M. RT A model for hormone receptor binding to the mouse mammary tumor virus RT regulatory element based on hydroxyl radical footprinting RL Nucleic Acids Res. 16:10237-10248 (1988). RN [33] RX MEDLINE; 88124257. RA Cordingley M. G., Hager G. L. RT Binding of multiple factors to the MMTV promoter in crude and fractionated RT nuclear extracts RL Nucleic Acids Res. 16:609-628 (1988). RN [34] RX MEDLINE; 87102873. RA Cordingley M. G., Riegel A. T., Hager G. L. RT Steroid-Dependent Interaction of Transcription Factors with the Inducible RT Promoter of Mouse Mammary Tumor Virus In Vivo RL Cell 48:261-270 (1987). RN [35] RX MEDLINE; 87090384. RA Willmann T., Beato M. RT Steroid-free glucocorticoid receptor binds specifically to mouse mammary RT tumor virus DNA RL Nature 324:688-691 (1986). RN [36] RX MEDLINE; 85137874. RA von der Ahe D., Janich S., Scheidereit C., Renkawitz R., Schuetz G., Beato RA M. RT Glucocorticoid and progesterone receptors bind the same sites in two RT hormonally regulated promoters RL Nature 313:706-709 (1985). RN [37] RX MEDLINE; 85215598. RA Nowock J., Borgmeyer U., Pueschel A. W., Rupp R. A. W., Sippel A. E. RT The TGGCA protein binds to the MMTV-LTR, the adenovirus origin of RT replication, and the BK virus enhancer RL Nucleic Acids Res. 13:2045-2061 (1985). RN [38] RX MEDLINE; 84221898. RA Scheidereit C., Beato M. RT Contacts between hormone receptor and DNA double helix within a RT glucocorticoid regulatory element of mouse mammary tumor virus RL Proc. Natl. Acad. Sci. USA 81:3029-3033 (1984). RN [39] RX MEDLINE; 84082063. RA Payvar F., DeFranco D., Firestone G. L., Edgar B., Wrange Oe., Okret S., RA Gustafsson J.-A., Yamamoto K. RT Sequence-Specific Binding of Glucocorticoid Receptor to MTV DNA at Sites RT within and Upstream of the Transcribed Region RL Cell 35:381-392 (1983). RN [40] RX MEDLINE; 83297683. RA Scheidereit C., Geisse S., Westphal H. M., Beato M. RT The glucocorticoid receptor binds to defined nucleotide sequences near the RT promoter of mouse mammary tumor virus RL Nature 304:749-752 (1983). XX // AC G000456 XX ID MOMLV$MOMULV XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Mo-MuLV XX DE Moloney murine leukemia virus XX OS Mo-MuLV, moloney murine leukemia virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; OC retroviridae; oncovirinae; type C oncovirus group; mammalian type C OC oncoviruses; murine leukemia viruses XX BC 6.2.1.2 XX BS -7877 -7855 R04838; MOMLV$MOMULV_21; Binding factors: YY1 . BS -407 -404 R01789; MOMLV$MOMULV_16; Binding factors: LBP . BS -352 -346 R01790; MOMLV$MOMULV_17; Binding factors: ELP . BS -328 -150 R03408; MOMLV$MOMULV_20. BS -86 -62 R01788; MOMLV$MOMULV_15. BS 147 167 R02335; MOMLV$MOMULV_18. BS 331 351 R02595; MOMLV$MOMULV_19; Binding factors: T3R-alpha , BS T3R-alpha , T3R-beta1 , T3R-beta1 , v-ErbA BS , RXR-alpha , T3R-beta2 , T3R-alpha , BS T3R-beta1 , T3R-beta2 . BS 7932 7937 R01134; MOMLV$MOMULV_01; Binding factors: LVa . BS 7939 7951 R01136; MOMLV$MOMULV_03; Binding factors: NF-1 . BS 7954 7960 R01138; MOMLV$MOMULV_05; Binding factors: LVb-binding factor BS . BS 7963 7970 R01140; MOMLV$MOMULV_07; Binding factors: NFdeltaE3A BS , MECA , core-binding factor . BS 7977 7981 R01142; MOMLV$MOMULV_09; Binding factors: LVc . BS 7984 7996 R01144; MOMLV$MOMULV_11; Binding factors: NF-1 . BS 7997 8006 R01146; MOMLV$MOMULV_13; Binding factors: GR . BS 8007 8012 R01135; MOMLV$MOMULV_02; Binding factors: LVa . BS 8014 8026 R01137; MOMLV$MOMULV_04; Binding factors: NF-1 . BS 8029 8035 R01139; MOMLV$MOMULV_06; Binding factors: LVb-binding factor BS . BS 8038 8045 R01141; MOMLV$MOMULV_08; Binding factors: NFdeltaE3A BS , MECA . BS 8050 8056 R01143; MOMLV$MOMULV_10; Binding factors: LVc . BS 8059 8071 R01145; MOMLV$MOMULV_12; Binding factors: NF-1 . BS 8072 8081 R01147; MOMLV$MOMULV_14; Binding factors: GR . XX DR EMBL: J02255; REMLM. DR TRANSPATH: G000456. DR TRANSCOMPEL: C00184. XX RN [1] RX MEDLINE; 95140631. RA Ye J., Young H. A., Ortaldo J. R., Ghosh P. RT Identification of a DNA binding site for the nuclear factor YY1 in the RT human GM-CSF core promoter RL Nucleic Acids Res. 22:5672-5678 (1994). RN [2] RX MEDLINE; 92255203. RA Halazonetis T. D. RT An enhancer core DNA-binding and transcriptional acitvity is induced upon RT transformation of rat embryo fibroblasts RL Anticancer Res. 12:285-292 (1992). RN [3] RX MEDLINE; 93024427. RA Redondo J. M., Pfohl J. L., Hernandez-Munain C., Wang S., Speck N. A., RA Krangel M. S. RT Indistinguishable nuclear factor binding to functional core sites of the RT T-cell receptor delta and murine leukemia virus enhancers RL Mol. Cell. Biol. 12:4817- 4823 (1992). RN [4] RX MEDLINE; 92186861. RA Tsukiyama T., Ueda H., Hirose S., Niwa O. RT Embryonal long terminal repeat-binding protein is a murine homolog of RT FTZ-F1, a member of the steroid receptor superfamily RL Mol. Cell. Biol. 12:1286-1291 (1992). RN [5] RX MEDLINE; 92107201. RA Wang S., Speck N. A. RT Purification of core-binding factor, a protein that binds the conserved RT core site in murine leukemia virus enhancers RL Mol. Cell. Biol. 12:89-102 (1992). RN [6] RX MEDLINE; 92037546. RA Vivanco Ruiz M. d. M., Bugge T. H., Hirschmann P., Stunnenberg H. G. RT Functional characterization of a natural retinoic acid responsive element RL EMBO J. 10:3829-3838 (1991). RN [7] RX MEDLINE; 92063894. RA Yen P. M., Darling D. S., Chin W. W. RT Basal and thyroid hormone receptor auxiliary protein-enhanced binding of RT thyroid hormone receptor isoforms to native thyroid hormone response RT elements RL Endocrinology 129:3331-3336 (1991). RN [8] RX MEDLINE; 91237813. RA Tsukiyama T., Niwa O., Yokoro K. RT Analysis of the binding proteins and activity of the long terminal repeat RT of Moloney murine leukemia virus during differentiation of mouse embryonal RT carcinoma cells RL J. Virol. 65:2979-2986 (1991). RN [9] RX MEDLINE; 91141469. RA Petersen R., Kempler G., Barklis E. RT A stem cell-specific silencer in the primer-binding site of a retrovirus RL Mol. Cell. Biol. 11:1214-1221 (1991). RN [10] RX MEDLINE; 91239520. RA Ronen D., Rotter V., Reisman D. RT Expression from the murine p53 promoter is mediated by factor binding to a RT downstream helix-loop-helix recognition motif RL Proc. Natl. Acad. Sci. USA 88:4128-4132 (1991). RN [11] RX MEDLINE; 90318369. RA Loh T. P., Sievert L. L., Scott R. W. RT Evidence for a stem cell-specific repressor of Moloney murine leukemia RT virus expression in embryonal carcinoma cells RL Mol. Cell. Biol. 10:4045-4057 (1990). RN [12] RX MEDLINE; 90097878. RA Tsukiyama T., Niwa O., Yokoro K. RT Mechanism of Suppression of the Long Terminal Repeat of Moloney Leukemia RT Virus in Mouse Embryonal Carcinoma Cells RL Mol. Cell. Biol. 9:4670-4676 (1989). RN [13] RX MEDLINE; 89330543. RA Sap J., Munoz A., Schmitt J., Stunnenberg H., Vennstroem B. RT Repression of transcription mediated at a thyroid hormone response element RT by the v-erb-A oncogene product RL Nature 340:242 (1989). RN [14] RX MEDLINE; 87172777. RA Speck N. A., Baltimore D. RT Six distinct nuclear factors interact with the 75-base-pair repeat of the RT moloney murine leukemia virus enhancer RL Mol. Cell. Biol. 7:1101-1110 (1987). XX // AC G000457 XX ID MOUSE$ACRD XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD AChR delta XX DE acetylcholine receptor, delta-subunit XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.15 XX BS -148 -95 R00018; MOUSE$ACRD_01; Binding factors: myogenin . BS -94 -53 R04461; MOUSE$ACRD_03. BS -29 -15 R00019; MOUSE$ACRD_02; Binding factors: MyoD , BS myogenin , E12 , E47 . XX DR EMBL: X13959; MMACHR. DR EMBL: M36684; MMACHRDA. DR TRANSPATH: G000457. DR TRRD: 00346. XX RN [1] RX MEDLINE; 93360949. RA Simon A. M., Burden S. J. RT An E box mediates activation and repression of the acetylcholine receptor RT delta-subunit gene during myogenesis RL Mol. Cell. Biol. 13:5133-5140 (1993). RN [2] RX MEDLINE; 90015215. RA Baldwin T. J., Burden S. J. RT Muscle-specific gene expression controlled by a regulatory element lacking RT a MyoD1-binding site RL Nature 341:716-720 (1989). XX // AC G000458 XX ID MOUSE$ACRG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD ACR-gamma XX DE acetylcholine receptor, gamma-subunit XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.15 XX BS -363 -334 R04020; MOUSE$ACRG_01; Binding factors: MyoD . BS -187 -155 R04021; MOUSE$ACRG_02; Binding factors: MyoD . XX DR EMBL: M22381; MMACHRA. DR TRANSPATH: G000458. XX RN [1] RX MEDLINE; 92041798. RA Gilmour B. P., Fanger G. R., Newton C., Evans S. M., Gardner P. D. RT Multiple binding sites for myogenic regulatory factors are required for RT expression of the acetylcholine receptor gamma-subunit gene RL J. Biol. Chem. 266:19871-19874 (1991). XX // AC G000459 XX ID MOUSE$ADA XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD ADA XX DE adenosine deaminase XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.2 XX BS -147 -139 R03721; MOUSE$ADA_01; Binding factors: Egr-1 . BS -144 -135 R03722; MOUSE$ADA_02; Binding factors: Sp1 . BS -109 -93 R04007; MOUSE$ADA_03; Binding factors: Sp1 . BS -86 -71 R04008; MOUSE$ADA_04; Binding factors: Sp1 . BS -61 -41 R04009; MOUSE$ADA_05; Binding factors: Sp1 . BS -27 -21 R04010; MOUSE$ADA_06; Binding factors: TBP . BS -21 -12 R04809; MOUSE$ADA_07. BS 20 30 R04811; MOUSE$ADA_08. XX DR EMBL: M34242; MMADAM01. DR TRANSPATH: G000459. DR BRENDA: 3.5.4.4. XX RN [1] RX MEDLINE; 94089732. RA Ackerman S. L., Minden A. G., Yeung C. Y. RT The minimal self-sufficient element in a murine G+C rich promoter is a RT large element with imperfect dyad symmetry RL Proc. Natl. Acad. Sci. USA 90:11865-11869 (1993). RN [2] RX MEDLINE; 92042082. RA Innis J. W., Moore D. J., Kash S. F., Ramamurthy V., Sawadogo M., Kellems RA R. E. RT The murine adenosine deaminase promoter requires an atypical TATA box which RT binds transcription factor IID and transcriptional activity is stimulated RT by multiple upstream Sp1 binding sites RL J. Biol. Chem. 266:21765-21772 (1991). RN [3] RX MEDLINE; 91352020. RA Ackerman S. L., Minden A. G., Williams G. T., Bobonis C., Yeung C. Y. RT Functional significance of an overlapping consensus binding motif for Sp1 RT and Zif268 in the murine adenosine deaminase gene promoter RL Proc. Natl. Acad. Sci. USA 88:7523-7527 (1991). XX // AC G000460 XX ID MOUSE$ADH1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Adh-1 XX DE alcohol dehydrogenase 1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4 XX BS -468 -323 R02372; MOUSE$ADH1_01. BS -232 -229 R02373; MOUSE$ADH1_02. BS -69 -57 R02374; MOUSE$ADH1_03. XX DR EMBL: M18472; MMADH1A1. DR BRENDA: 1.1.1.1; Mouse. XX RN [1] RX MEDLINE; 89378754. RA Carr L. G., Zhang K., Edenberg H. J. RT Protein-DNA interaction in the 5' region of the mouse alcohol dehydrogenase RT gene Adh-1 RL Gene 78:277-285 (1989). XX // AC G000461 XX ID MOUSE$ADH2 XX DT 14.06.1995 (created); dbo. DT 20.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Adh-2 XX DE alcohol dehydrogenase 2 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4 XX BS empty empty R04253; MOUSE$ADH2_01; Binding factors: TFE3-S . XX DR TRANSPATH: G000461. DR BRENDA: 1.1.1.1; Mouse. XX RN [1] RX MEDLINE; 92123207. RA Roman C., Matera A. G., Cooper C., Artandi S., Blain S., Ward D. C., Calame RA K. RT mTFE3, an X-linked transcriptional activator containing basic RT helix-loop-helix and zipper domains, utilizes the zipper to stabilize both RT DNA binding and multimerization RL Mol. Cell. Biol. 12:817-827 (1992). XX // AC G000462 XX ID MOUSE$ADIP XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD adipsin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.7.1 XX BS -114 -70 R02600; MOUSE$ADIP_01. BS -69 -42 R02601; MOUSE$ADIP_02. XX DR EMBL: X04673; MMADIG. DR EMBL: K03476; MMADN. XX RN [1] RX MEDLINE; 90094442. RA Wilkison W. O., Min H. Y., Claffey K. P., Satterberg B. L., Spiegelman B. M. RT Control of the Adipsin Gene in Adipocyte Differentiation RL J. Biol. Chem. 265:477-482 (1990). XX // AC G000463 XX ID MOUSE$AGP XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD AGP-1 XX DE alpha1-acid glycoprotein XX OS mouse, Mus domesticus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.6 XX BS -127 -104 R12403; MOUSE$AGP_03; Binding factors: GR . BS -121 -94 R02460; MOUSE$AGP_01; Binding factors: C/EBPbeta , BS C/EBPalpha , C/EBPalpha , ANF-2 . BS -85 -70 R02461; MOUSE$AGP_02; Binding factors: C/EBPbeta , BS C/EBPalpha , C/EBPalpha , ANF-2 . XX DR EMBL: M34644; MCAGP8A. DR EMBL: S38220; S38220. DR EMBL: S38221; S38221. DR TRANSPATH: G000463. DR TRRD: 00228. XX RN [1] RX MEDLINE; 99160400. RA Rabek J. P., Papaconstantinou J. RT Interference mapping of nuclear protein binding to the acute phase response RT element of the mouse alpha1 acid glycoprotein gene RL Biochem. Biophys. Res. Commun. 255:608-613 (1999). RN [2] RX MEDLINE; 92162690. RA Alam T., Papaconstantinou J. RT Interaction of acute-phase-inducible and liver-enriched nuclear factors RT with the promoter region of the mouse alpha 1-acid glycoprotein gene-1 RL Biochemistry 31:1928-1936 (1992). RN [3] RX MEDLINE; 91061773. RA Chang C.-J., Chen T.-T., Lei H.-Y., Chen D.-Sh., Lee Sh.-Ch. RT Molecular cloning of a transcription factor, AGP/EBP, that belongs to RT members of the C/EBP family RL Mol. Cell. Biol. 10:6642-6653 (1990). XX // AC G000464 XX ID MOUSE$ALBU XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Alb XX DE albumin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.4 XX BS -10190 -10181 R00082; MOUSE$ALBU_01; Binding factors: C/EBPalpha . BS -10150 -10132 R00083; MOUSE$ALBU_02; Binding factors: C/EBPalpha . BS -10029 -9993 R00084; MOUSE$ALBU_03; Binding factors: NLS1 . BS -8750 -8700 R00085; MOUSE$ALBU_04; Binding factors: NF-1 . BS -8741 -8724 R00086; MOUSE$ALBU_05; Binding factors: HNF-3alpha . BS -8607 -8581 R02333; MOUSE$ALBU_12; Binding factors: ANF , ANF BS , ANF . BS -8468 -8445 R02334; MOUSE$ALBU_13; Binding factors: ANF , ANF BS , ANF . BS -164 -139 R00087; MOUSE$ALBU_06. BS -147 -113 R00088; MOUSE$ALBU_07; Binding factors: NF-1 , NF-1 BS . BS -114 -93 R00089; MOUSE$ALBU_08; Binding factors: C/EBPalpha , BS C/EBPgamma , C/EBPbeta , C/EBPbeta(p20) , DBP BS . BS -96 -69 R00090; MOUSE$ALBU_09; Binding factors: CBF (2) , BS C/EBPalpha , CP2 , NF-Y . BS -72 -48 R00091; MOUSE$ALBU_10; Binding factors: HNF-1 , HP1 BS site factor . BS -53 -32 R00093; MOUSE$ALBU_11; Binding factors: C/EBPalpha . BS 71 90 R02964; MOUSE$ALBU_14. BS 123 151 R02965; MOUSE$ALBU_15. BS 161 179 R02966; MOUSE$ALBU_16. BS 362 384 R02967; MOUSE$ALBU_17. BS 408 427 R02968; MOUSE$ALBU_18; Binding factors: eE-TF . BS 511 533 R02969; MOUSE$ALBU_19. BS 528 547 R02970; MOUSE$ALBU_20; Binding factors: HNF-1A , BS HNF-1B , HNF-1C , HNF-3 . BS 532 543 R08080; MOUSE$ALBU_25; Binding factors: HNF-3 . BS 563 592 R02971; MOUSE$ALBU_21; Binding factors: eH-TF , EBP40 BS , EBP45 . BS 691 711 R02972; MOUSE$ALBU_22. BS 715 722 R02973; MOUSE$ALBU_23. BS 725 752 R02974; MOUSE$ALBU_24. XX DR EMBL: J00350; MMALB5E. DR EMBL: M63182; MMALBENA. DR EMBL: M14768; MMALBPAA. DR TRANSPATH: G000464. XX RN [1] RX MEDLINE; 92084734. RA Petropoulos I., Auge-Gouillou C., Zakin M. M. RT Characterization of the active part of the human transferrin gene enhancer RT and purification of two liver nuclear factors interacting with the TGTTTGC RT motif present in this region RL J. Biol. Chem. 266:24220-24225 (1991). RN [2] RX MEDLINE; 92046085. RA Tronche F., Rollier A., Sourdive D., Cereghini S., Yaniv M. RT NFY or a related CCAAT binding factor can be replaced by other RT transcriptional activators for co-operation with HNF1 in driving the rat RT albumin promoter in vivo RL J. Mol. Biol. 222:31-43 (1991). RN [3] RX MEDLINE; 91117244. RA Liu J.-K., DiPersio C. M., Zaret K. S. RT Extracellular signals that regulate liver transcription factors during RT hepatic differentiation in vitro RL Mol. Cell. Biol. 11:773-784 (1991). RN [4] RX MEDLINE; 91342641. RA DiPersio C. M., Jackson D. A., Zaret K. S. RT The extracellular matrix coordinately modulates liver transcription factors RT and hepatocyte morphology RL Mol. Cell. Biol. 11:4405-4414 (1991). RN [5] RX MEDLINE; 92034979. RA Descombes P., Schibler U. RT A liver-enriched transcriptional activator protein, LAP, and a RT transcriptional inhibitory protein, LIP, are translated from the same mRNA RL Cell 67:569-579 (1991). RN [6] RX MEDLINE; 90235277. RA Mueller C. R., Maire P., Schibler U. RT DBP, a liver-enriched transcriptional activator, is expressed late in RT ontogeny and its tissue specificity is determined posttranscriptionally RL Cell 61:279-291 (1990). RN [7] RX MEDLINE; 91032992. RA Roman C., Platero J. S., Shuman J., Clamae K. RT Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein RT that is similar to C/EBP and heterodimerizes with C/EBP RL Genes Dev. 4:1404-1415 (1990). RN [8] RX MEDLINE; 91071582. RA Descombes P., Chojkier M., Lichtsteiner S., Falvey E., Schibler U. RT LAP, a novel member of the C/EBP gene family, encodes a liver-enriched RT transcriptional activator protein RL Genes Dev. 4:1541-1551 (1990). RN [9] RX MEDLINE; 90318354. RA Herbst R. S., Boczko E. M., Darnell jr J. E., Babiss L. E. RT The mouse albumin enhancer contains a negative regulatory element that RT interacts with a novel DNA-binding protein RL Mol. Cell. Biol. 10:3896-3905 (1990). RN [10] RX MEDLINE; 91061771. RA Li X., Huang J. H., Rienhoff jr H. Y., Liao W. S.-L. RT Two adjacent C/EBP-binding sequences that participate in the cell-specific RT expression of the mouse serum amyloid A3 gene RL Mol. Cell. Biol. 10:6624-6631 (1990). RN [11] RX MEDLINE; 90319133. RA Zaret K. S., Liu J.-K., DiPersio C. M. RT Site-directed mutagenesis reveals a liver transcription factor essential RT for the albumin transcriptional enhancer RL Proc. Natl. Acad. Sci. USA 87:5469-5473 (1990). RN [12] RX MEDLINE; 89288319. RA Lichtsteiner S., Schibler U. RT A Glycosylated Liver-Specific Transcription Factor Stimulates Transcription RT of the Albumin Gene RL Cell 57:1179-1187 (1989). RN [13] RX MEDLINE; 89160814. RA Herbst R. S., Friedman N., Darnell J. E., Babiss L. E. RT Positive and negative regulatory elements in the mouse albumin enhancer RL Proc. Natl. Acad. Sci. USA 86:1553-1557 (1989). RN [14] RX MEDLINE; 89222448. RA Maire P., Wuarin J., Schibler U. RT The Role of Cis-Acting Promoter Elements in Tissue-Specific Albumin Gene RT Expression RL Science 244:343-346 (1989). RN [15] RX MEDLINE; 88233915. RA Kugler W., Wagner U., Ryffel G. U. RT Tissue-specificity of liver gene expression: a common liver-specific RT promoter element RL Nucleic Acids Res. 16:3165-3174 (1988). RN [16] RX MEDLINE; 88080483. RA Lichtsteiner S., Wuarin J., Schibler U. RT The Interplay of DNA-Binding Proteins on the Promoter of the Mouse Albumin RT Gene RL Cell 51:963-973 (1987). XX // AC G000465 XX ID MOUSE$SAACT XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD SA-ACT XX DE skeletal alpha-actin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.5.1 XX BS -152 -41 R03000; MOUSE$SAACT_01; Binding factors: YY1 . XX DR EMBL: M12347; MMACASA. DR TRANSPATH: G000465. DR TRRD: 00313. XX RN [1] RX MEDLINE; 91141533. RA Riggs K. J., Merrell K. T., Wilson G., Calame K. RT Common factor 1 is a transcriptional activator which binds in the c.myc RT promoter, the skeletal alpha-actin promoter, and the immunoglobulin RT heavy-chain enhancer RL Mol. Cell. Biol. 11:1765-1769 (1991). XX // AC G000466 XX ID MOUSE$AAMY XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD AAMY XX DE alpha-amylase XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4 XX BS -209 -158 R00105; MOUSE$AAMY_01. BS -157 -120 R00106; MOUSE$AAMY_02; Binding factors: PTF1-beta , BS PTF1 , PTF1-alpha . BS -157 -121 R01835; MOUSE$AAMY_07; Binding factors: PTF1-beta . BS -157 -121 R01836; MOUSE$AAMY_08; Binding factors: PTF1-beta . BS -127 -87 R00107; MOUSE$AAMY_03. BS -88 -60 R00108; MOUSE$AAMY_04. BS -51 -20 R00109; MOUSE$AAMY_05. BS -35 -20 R00110; MOUSE$AAMY_06. XX DR EMBL: X02343; MMAMY2. DR TRANSPATH: G000466. DR BRENDA: 3.2.1.1; Animals. XX RN [1] RX MEDLINE; 92069764. RA Sommer L., Hagenbuechle O., Wellauer P. K., Strubin M. RT Nuclear targeting of the transcription factor PTF1 is mediated by a protein RT subunit that does not bind to the PTF1 cognate sequence RL Cell 67:987-994 (1991). RN [2] RX MEDLINE; 90097834. RA Petrucco S., Wellauer P. K., Hagenbuechle O. RT The DNA-Binding Activity of Transcription Factor PTF1 Parallels the RT Synthesis of Pancreas-Specific mRNAs during Mouse Development RL Mol. Cell. Biol. 10:254-264 (1990). RN [3] RX MEDLINE; 90128261. RA Roux E., Strubin M., Hagenbuechle O., Wellauer P. K. RT The cell-specific transcription factor PTF1 contains two different subunits RT that interact with the DNA RL Genes Dev. 3:1613-1624 (1989). RN [4] RX MEDLINE; 89343964. RA Cockell M., Stevenson B. J., Strubin M., Hagenbuechle O., Wellauer P. K. RT Identification of a Cell-Specific DNA-Binding Activity That Interacts with RT a Transcriptional Activator of Genes Expressed in the Acinar Pancreas RL Mol. Cell. Biol. 9:2464-2476 (1989). XX // AC G000467 XX ID MOUSE$AFEP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD AFP XX DE alpha-fetoprotein XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.4 XX BS -805 -789 R02033; MOUSE$AFEP_02. BS -780 -754 R02034; MOUSE$AFEP_03. BS -743 -731 R02035; MOUSE$AFEP_04. BS -589 -550 R02036; MOUSE$AFEP_05. BS -544 -514 R02037; MOUSE$AFEP_06. BS -445 -403 R02038; MOUSE$AFEP_07. BS -331 -310 R02039; MOUSE$AFEP_08. BS -290 -261 R02040; MOUSE$AFEP_09. BS -247 -229 R02041; MOUSE$AFEP_10. BS -201 -177 R02042; MOUSE$AFEP_11; Binding factors: C/EBPalpha , BS NP-Va . BS -169 -152 R02043; MOUSE$AFEP_12; Binding factors: NP-IV . BS -146 -131 R02044; MOUSE$AFEP_13; Binding factors: NP-III . BS -128 -68 R02045; MOUSE$AFEP_14; Binding factors: C/EBPalpha , BS HNF-1 , NF-1 , HNF-1A . BS -82 -63 R02046; MOUSE$AFEP_15; Binding factors: C/EBPalpha . BS -82 -44 R04019; MOUSE$AFEP_16; Binding factors: HNF-1A . BS -65 -50 R00434; MOUSE$AFEP_01; Binding factors: HP1 site factor BS . XX DR EMBL: J05246; MMAFETO. DR EMBL: J00349; MMAFP14Z. DR TRANSPATH: G000467. DR TRRD: 00267. XX RN [1] RX MEDLINE; 92041994. RA Zhang D.-E., Ge X., Rabek J. P., Papaconstantinou J. RT Functional analysis of the trans-acting factor binding sites of the mouse RT alpha-fetoprotein proximal promoter by site-directed mutagenesis RL J. Biol. Chem. 266:21179-21185 (1991). RN [2] RX MEDLINE; 90153995. RA Zhang D.-E., Hoyt P. R., Papaconstantinou J. RT Localization of DNA Protein-binding Sites in the Proximal and Distal RT Promoter Regions of the Mouse alpha-Fetoprotein Gene RL J. Biol. Chem. 265:3382-3391 (1990). RN [3] RX MEDLINE; 88233915. RA Kugler W., Wagner U., Ryffel G. U. RT Tissue-specificity of liver gene expression: a common liver-specific RT promoter element RL Nucleic Acids Res. 16:3165-3174 (1988). XX // AC G000468 XX ID MOUSE$AG XX DT 21.05.1996 (created); ake. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-A1 XX DE alpha1-globin XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.10.2 XX DR TRRD: 00004. XX // AC G000469 XX ID MOUSE$A11COL XX DT 14.06.1995 (created); dbo. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD A1(1) COL XX DE alpha1(I) collagen XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.7 XX BS -400 -380 R03289; MOUSE$A11COL_05. BS -361 -339 R03290; MOUSE$A11COL_06. BS -194 -170 R02871; MOUSE$A11COL_02; Binding factors: IF1 . BS -160 -134 R02872; MOUSE$A11COL_03; Binding factors: IF1 . BS -132 -107 R02873; MOUSE$A11COL_04; Binding factors: IF2 , NF-1 BS , Sp1 , Sp1 . BS -113 -84 R00228; MOUSE$A11COL_01; Binding factors: CBF (2) , BS IF2 . BS -105 -78 R03336; MOUSE$A11COL_07; Binding factors: NF-1 , Sp1 BS , Sp1 . XX DR EMBL: M61011; MMAL1CO. DR TRANSPATH: G000469. DR SMARTDB: SM0000396. DR SMARTDB: SM0000397. DR SMARTDB: SM0000398. DR SMARTDB: SM0000399. DR SMARTDB: SM0000400. DR SMARTDB: SM0000403. DR SMARTDB: SM0000405. XX RN [1] RX MEDLINE; 91210242. RA Ravazzolo R., Karsenty G., de Crombrugghe B. RT A fibroblast-specific factor binds to an upstream negative control element RT in the promoter of the mouse alpha1(I) collagen gene RL J. Biol. Chem. 266:7382-7387 (1991). RN [2] RX MEDLINE; 91304398. RA Nehls M. C., Rippe R. A., Veloz L., Brenner D. A. RT Transcription factors nuclear factor I and Sp1 interact with the murine RT collagen alpha1(I) promoter RL Mol. Cell. Biol. 11:4065-4073 (1991). RN [3] RX MEDLINE; 90277689. RA Karsenty G., de Crombrugghe B. RT Two different negative and one positive regulatory factors interact with a RT short promoter segment of the alpha1(I) collagen gene RL J. Biol. Chem. 265:9934-9942 (1990). RN [4] RX MEDLINE; 88290678. RA Maity S. N., Golumbek P. T., Karsenty G., de Crombrugghe B. RT Selective Activation of Transcription by a Novel CCAAT Binding Factor RL Science 241:582-584 (1988). XX // AC G000470 XX ID MOUSE$A13COL XX DT 21.05.1996 (created); ake. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD A1(3) COL XX DE alpha1(III) collagen XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.7 XX BS empty empty R08115; MOUSE$A13COL_01; Binding factors: C/EBPalpha BS . XX DR TRANSPATH: G000470. DR TRRD: 00017. XX RN [1] RX MEDLINE; 94266835. RA Jotte R. M., Kamata N., Holt J. T. RT Myristylation-dependent transactivation by FBR v-fos is regulated by C/EBP RL J. Biol. Chem. 269:16383-16396 (1994). XX // AC G000471 XX ID MOUSE$A14COL XX DT 14.06.1995 (created); dbo. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD A1(4) COL XX DE alpha1(IV) collagen XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.7 XX BS 3 19 R03897; MOUSE$A14COL_01. BS 189 204 R03898; MOUSE$A14COL_02. XX RN [1] RX MEDLINE; 92042164. RA Burbelo P. D., Bruggeman L. A., Gabriel G. C., Klotman P. E., Yamada Y. RT Characterization of a cis-acting element required for efficient RT transcriptional activation of the collagen IV enhancer RL J. Biol. Chem. 266:22297-22302 (1991). XX // AC G000472 XX ID MOUSE$A1ANTR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD AAT XX DE alpha1-antitrypsin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.3 XX BS -465 -441 R00125; MOUSE$A1ANTR_01; Binding factors: C/EBPalpha BS , C/EBPalpha . BS -378 -366 R08919; MOUSE$A1ANTR_04; Binding factors: HNF-3B . BS -292 -282 R00126; MOUSE$A1ANTR_02; Binding factors: AP-1 , AP-1 BS . BS -210 -185 R00127; MOUSE$A1ANTR_03; Binding factors: C/EBPalpha . BS -195 -184 R08921; MOUSE$A1ANTR_05; Binding factors: HNF-6alpha BS , HNF-6beta . XX DR TRANSPATH: G000472. DR TRRD: 00168. XX RN [1] RX MEDLINE; 97042457. RA Samadani U., Costa R. H. RT The transcriptional activator hepatocyte nuclear factor 6 regulates liver RT gene expression RL Mol. Cell. Biol. 16:6273-6284 (1996). RN [2] RX MEDLINE; 89285897. RA Grayson D. R., Costa R. H., Darnell J. E. RT Regulation of hepatocyte-specific gene expression RL Ann. N. Y. Acad. Sci. 557:243-255 (1989). RN [3] RX MEDLINE; 88216579. RA Grayson D. R., Costa R. H., Xanthopoulos K. G., Darnell jr J. E. RT A Cell-Specific Enhancer of the Mouse alpha1-Antitrypsin Gene Has Multiple RT Functional Regions and Corresponding Protein-Binding Sites RL Mol. Cell. Biol. 8:1055-1066 (1988). RN [4] RX MEDLINE; 88234517. RA Costa R. H., Grayson D. R., Xanthopoulos K. G., Darnell jr J. E. RT A liver-specific DNA-binding protein recognizes multiple nucleotide sites RT in regulatory regions of transthyretin, alpha1-antitrypsin, albumin, and RT simian virus 40 genes RL Proc. Natl. Acad. Sci. USA 85:3840-3844 (1988). RN [5] RX MEDLINE; 88127142. RA Grayson D. R., Costa R. H., Xanthopoulos K. G., Darnell J. E. RT One Factor Recognizes the Liver-Specific Enhancers in alpha1-Antitrypsin RT and Transthyretin Genes RL Science 239:786-788 (1988). XX // AC G000473 XX ID MOUSE$A1PI XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD alpha1-PI XX DE alpha1-protease inhibitor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.3 XX BS -2998 -2980 R02674; MOUSE$A1PI_01; Binding factors: AP-1 . BS -314 -299 R02675; MOUSE$A1PI_02. BS -280 0 R02676; MOUSE$A1PI_03; Binding factors: AP-1 . BS -256 0 R02677; MOUSE$A1PI_04. BS -220 -180 R02678; MOUSE$A1PI_05; Binding factors: C/EBPalpha , BS HNF-3 . XX DR TRANSPATH: G000473. XX RN [1] RX MEDLINE; 90258848. RA Montgomery K. T., Tardiff J. T., Reid L. M., Krauter K. S. RT Negative and Positive cis-Acting Elements Control the Expression of Murine RT alpha1-Protease Inhibitor Genes RL Mol. Cell. Biol. 10:2625-2637 (1990). RN [2] RX MEDLINE; 89261769. RA Costa R. H., Grayson D. R., Darnell J. E. RT Multiple hepatocyte-enriched nuclear factors function in the regulation of RT transthyretin and alpha1-antitrypsin genes RL Mol. Cell. Biol. 9:1415-1425 (1989). XX // AC G000474 XX ID MOUSE$A21COL XX DT 14.06.1995 (created); dbo. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD A2(1) COL XX DE alpha2(I) collagen XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.7 XX BS -350 -103 R00230; MOUSE$A21COL_02. BS -315 -295 R00229; MOUSE$A21COL_01; Binding factors: NF-1 , NF-1 BS . BS -176 -152 R04672; MOUSE$A21COL_06. BS -131 -114 R04673; MOUSE$A21COL_07. BS -108 54 R00231; MOUSE$A21COL_03; Binding factors: CCAAT-binding BS factor . BS -100 -73 R00232; MOUSE$A21COL_04; Binding factors: CBF (2) , BS CBF-A , CBF-B . BS -95 -70 R00233; MOUSE$A21COL_05; Binding factors: EFI . BS 871 881 R04741; MOUSE$A21COL_09; Binding factors: Sp1 . BS 983 1008 R04740; MOUSE$A21COL_08. XX DR EMBL: K01832; MMC1A2. DR TRANSPATH: G000474. XX RN [1] RX MEDLINE; 96371074. RA Hasegawa T., Zhou X., Garrett L. A., Ruteshouser E. C., Maity S. N., de RA Crombrugghe B. RT Evidence for three major transcription activation elements in the proximal RT mouse proalpha2(I) collagen promoter RL Nucleic Acids Res. 24:3253-3260 (1996). RN [2] RX MEDLINE; 93155056. RA Pogulis R. J., Freytag S. O. RT Contribution of specific cis-acting elements to activity of the mouse RT pro-alpha2(I) collagen enhancer RL J. Biol. Chem. 268:2493-2499 (1993). RN [3] RX MEDLINE; 91093062. RA Faber M., Sealy L. RT Rous sarcoma virus enhancer factor I is a ubiquitous CCAAT transcription RT factor highly related to CBF and NF-Y RL J. Biol. Chem. 265:22243-22254 (1990). RN [4] RX MEDLINE; 91093096. RA Vuorio T., Maity S. N., de Crombrugghe B. RT Purification and molecular cloning of the A chain of a rat heteromeric RT CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription RT factor RL J. Biol. Chem. 265:22480-22486 (1990). RN [5] RX MEDLINE; 90319116. RA Maity S. N., Vuorio T., de Crombrugghe B. RT The B subunit of a rat heteromeric CCAAT-binding transcription factor shows RT a striking sequence identity with the yeast Hap2 transcription factor RL Proc. Natl. Acad. Sci. USA 87:5378-5382 (1990). RN [6] RX MEDLINE; 88151045. RA Rossi P., Karsenty G., Roberts A. B., Roche N. S., Sporn M. B., de RA Crombrugghe B. RT A Nuclear Factor I Binding Site Mediates the Transcriptional Activation of RT a Type I Collagen Promoter by Transforming Growth Factor-beta RL Cell 52:405-414 (1988). RN [7] RX MEDLINE; 88330929. RA Karsenty G., Golumbek P., de Crombrugghe B. RT Point Mutations and Small Substitution Mutations in Three Different RT Upstream Elements Inhibit the Activity of the Mouse alpha2(I) Collagen RT Promoter RL J. Biol. Chem. 263:13909-13915 (1988). RN [8] RX MEDLINE; 88290678. RA Maity S. N., Golumbek P. T., Karsenty G., de Crombrugghe B. RT Selective Activation of Transcription by a Novel CCAAT Binding Factor RL Science 241:582-584 (1988). RN [9] RX MEDLINE; 87280193. RA Oikarinen J., Hatamochi A., de Crombrugghe B. RT Separate Binding Sites for Nuclear Factor 1 and a CCAAT DNA Binding Factor RT in the Mouse alpha2(I) Collagen Promoter RL J. Biol. Chem. 262:11064-11070 (1987). RN [10] RX MEDLINE; 86278237. RA Hatamochi A., Paterson B., de Crombrugghe B. RT Differential binding of a CCAAT DNA binding factor to the promoters of the RT mouse alpha2(I) and alpha1(III) collagen genes RL J. Biol. Chem. 261:11310-11314 (1986). XX // AC G000475 XX ID MOUSE$AACR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CRY-alphaA XX DE alphaA-crystallin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.9 XX BS -111 -97 R04753; MOUSE$AACR_05. BS -103 -90 R00249; MOUSE$AACR_01. BS -97 -91 R00250; MOUSE$AACR_02. BS -79 -72 R00251; MOUSE$AACR_03. BS -66 -57 R01628; MOUSE$AACR_04; Binding factors: alphaA-CRYBP1 . XX DR EMBL: J00375; MMCRYAAA. DR EMBL: V00730; MMCRYS. DR TRANSPATH: G000475. XX RN [1] RX MEDLINE; 93324326. RA Sax C. M., Ilagen J. G., Piatigorsky J. RT Functional redundancy of the DE-1 and alphaA-CRYBP1 regulatory sites of the RT mouse alphaA-crystallin promoter RL Nucleic Acids Res. 21:2633-2640 (1993). RN [2] RX MEDLINE; 94010304. RA Kantorow M., Becker K., Sax C. M., Ozato K., Piatigorsky J. RT Binding of tissue-specific forms of AlphaA-CRYBP1 to their regulatory RT sequence in the mouse AlphaA-crystallin-encoding gene: Double-label RT immunoblotting of UV-crosslinked complexes RL Gene 131:159-165 (1993). RN [3] RX MEDLINE; 90287161. RA Nakamura T., Donovan D. M., Hamada K., Sax C. M., Norman B., Flanagan J. RA R., Ozato K., Westphal H., Piatigorsky J. RT Regulation of the mouse alphaA-crystallin gene: isolation of a cDNA RT encoding a protein that binds to a cis sequence motif shared with the major RT histocompability complex class I gene and other genes RL Mol. Cell. Biol. 10:3700-3708 (1990). RN [4] RX MEDLINE; 89008476. RA Sommer B., Chepelinsky A. B., Piatigorsky J. RT Binding of Nuclear Proteins to Promoter Elements of the Mouse RT alphaA-crystallin Gene RL J. Biol. Chem. 263:15666-15672 (1988). XX // AC G000476 XX ID MOUSE$AAG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-AA XX DE alphaA-globin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.9.2 XX BS -192 -178 R00507; MOUSE$AAG_01; Binding factors: GATA-1 , BS GATA-1 , GATA-1 , GATA-3 , GATA-3 , NF-E1b BS . BS -189 -173 R00508; MOUSE$AAG_02. BS -159 -149 R04167; MOUSE$AAG_07; Binding factors: CP2 . BS -132 -87 R00509; MOUSE$AAG_03; Binding factors: alpha-CP2a, alpha-CP2b BS . BS -132 -122 R04168; MOUSE$AAG_08; Binding factors: CP2 . BS -130 -10 R00510; MOUSE$AAG_04; Binding factors: alpha-CP1 , BS alpha-CP2a, alpha-CP2b , alpha-IRP . BS -116 -106 R04169; MOUSE$AAG_09; Binding factors: CP2 . BS -103 -92 R04170; MOUSE$AAG_10; Binding factors: CP2 . BS -102 -74 R00511; MOUSE$AAG_05; Binding factors: CCAAT-binding factor BS , alpha-CP1 , CCAAT-binding factor , alpha-CP1 BS . BS 1042 0 R00512; MOUSE$AAG_06; Binding factors: GATA-1 . XX DR EMBL: V00714; MMAGL1. DR EMBL: M12931; MMHBAC. DR EMBL: X05379; MMLAPGLOB. DR TRANSPATH: G000476. DR SMARTDB: SM0000169. XX RN [1] RX MEDLINE; 90351381. RA Perkins N. D., Orchard K. H., Collins M. L. K., Latchman D. S., Goodwin G. RA H. RT Detection in non-erythroid cells of a factor with binding characteristics RT of the erythroid cell transcription factor EF1 RL Biochem. J. 269:543-545 (1990). RN [2] RX MEDLINE; 91065513. RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D. RT Activity and tissue-specific expression of the transcription factor NF-E1 RT multigene family RL Genes Dev. 4:1650-1662 (1990). RN [3] RX MEDLINE; 90330687. RA Kim C. G., Sheffery M. RT Physical characterization of the purified CCAAT transcription factor, RT alpha-CP1 RL J. Biol. Chem. 265:13362-13369 (1990). RN [4] RX MEDLINE; 91042527. RA Kim C. G., Swendeman S. L., Barnhart K. M., Sheffery M. RT Promoter elements and erythroid cell nuclear factors that regulate RT alpha-globin gene transcription in vitro RL Mol. Cell. Biol. 10:5958-5966 (1990). RN [5] RX MEDLINE; 89343978. RA Barnhart K. M., Kim C. G., Sheffery M. RT Purification and characterization of an erythroid cell-specific factor that RT binds the murine alpha- and beta-globin genes RL Mol. Cell. Biol. 9:2606-2614 (1989). RN [6] RX MEDLINE; 89098433. RA Plumb M., Frampton J., Wainwright H., Walker M., MacLeod K., Goodwin G., RA Harrison P. RT GATAAG; a cis-control region binding an erythroid-specific nuclear factor RT with a role in globin and non-globin gene expression RL Nucleic Acids Res. 17:73-92 (1989). RN [7] RX MEDLINE; 89096909. RA Barnhart K. M., Kim C. G., Banerji S. S., Sheffery M. RT Identification and Characterization of Multiple Erythroid Cell Proteins RT That Interact with the Promoter of the Murine alpha-Globin Gene RL Mol. Cell. Biol. 8:3215-3226 (1988). RN [8] RX MEDLINE; 89039854. RA Kim C. G., Barnhart K. M., Sheffery M. RT Purification of Multiple Erythroid Cell Proteins That Bind the Promoter of RT the alpha-Globin Gene RL Mol. Cell. Biol. 8:4270-4281 (1988). RN [9] RX MEDLINE; 87039102. RA Cohen R. B., Sheffery M., Kim C. G. RT Partial purification of a nuclear protein that binds to the CCAAT box of RT the mouse alpha1-globin gene RL Mol. Cell. Biol. 6:821-832 (1986). XX // AC G000477 XX ID MOUSE$AMYX XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD amy-x XX DE amylase XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4 XX BS -172 -110 R02758; MOUSE$AMYX_01; Binding factors: PTF1 . XX DR EMBL: X02949; MMAMY2X. DR TRANSPATH: G000477. XX RN [1] RX MEDLINE; 91032983. RA Keller S. A., Rosenberg M. P., Johnson Th. M., Howard G., Meisler M. RT Regulation of amylase gene expression in diabetic mice is mediated by a RT cis-acting upstream element close to the pancreas-specific enhancer RL Genes Dev. 4:1316-1321 (1990). XX // AC G000478 XX ID MOUSE$AP2 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD AP2 XX DE adipocyte protein P2 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.13 XX BS -159 -129 R01817; MOUSE$AP2_04; Binding factors: C/EBPalpha . BS -149 -130 R01839; MOUSE$AP2_03; Binding factors: C/EBPalpha . BS -124 -101 R00133; MOUSE$AP2_01; Binding factors: AP-1 , AP-1 BS , AP-1 . BS -124 -101 R00134; MOUSE$AP2_02. BS -60 0 R01818; MOUSE$AP2_05; Binding factors: C/EBPalpha . BS -45 0 R01819; MOUSE$AP2_06. BS -5 0 R03106; MOUSE$AP2_07; Binding factors: NF-1 , NF-1 BS . XX DR EMBL: M84651; MMAP2A. DR EMBL: M13261; MMP2AD1. DR TRANSPATH: G000478. DR TRRD: 00061. XX RN [1] RX MEDLINE; 91160975. RA Graves R. A., Tontonoz P., Ross S. R., Spiegelman B. M. RT Identification of a potent adipocyte-specific enhancer: involvement of an RT NF-1-like factor RL Genes Dev. 5:428-437 (1991). RN [2] RX MEDLINE; 91172221. RA Ro H.-S., Roncari D. A. K. RT The C/EBP-binding region and adjacent sites regulate expression of the RT adipose P2 gene in human preadipocytes RL Mol. Cell. Biol. 11:2303-2306 (1991). RN [3] RX MEDLINE; 90108682. RA Christy R. J., Yang V. W., Ntambi J. M., Geiman D. E., Landschulz W. H., RA Friedman A. D., Nakabeppu Y., Kelly T. J., Lane M. D. RT Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/ RT enhancer binding protein interacts with and activates the promoters of two RT adipocyte-specific genes RL Genes Dev. 3:1323-1335 (1989). RN [4] RX MEDLINE; 89252808. RA Hay N., Takimoto M., Bishop J. M. RT A FOS protein is present in a complex that binds a negative regulator of MYC RL Genes Dev. 3:293-303 (1989). RN [5] RX MEDLINE; 90066483. RA Herrera R., Ro H. S., Robinson G. S., Xanthopoulos K. G., Spiegelman B. M. RT A Direct Role for C/EBP and the AP-I-Binding Site in Gene Expression Linked RT to Adipocyte Differentiation RL Mol. Cell. Biol. 9:5331-5339 (1989). RN [6] RX MEDLINE; 89365144. RA Kouzarides T., Ziff E. RT Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and RT thereby control DNA binding RL Nature 340:568-571 (1989). RN [7] RX MEDLINE; 88151051. RA Rauscher III F. J., Sambucetti L. C., Curran T., Distel R. J., Spiegelman RA B. M. RT Common DNA Binding Site for FOS Protein Complexes and Transcription Factor RT AP-1 RL Cell 52:471-480 (1988). RN [8] RX MEDLINE; 89070696. RA Kouzarides T., Ziff E. RT The role of the leucine zipper in the fos-jun interaction RL Nature 336:646-651 (1988). RN [9] RX MEDLINE; 88145673. RA Franza jr B. R., Rauscher III F. J., Josephs S. F., Curran T. RT The Fos-complex and Fos-related antigens recognize sequence elements that RT contain AP-2 binding sites RL Science 239:1150-1153 (1988). RN [10] RX MEDLINE; 87215947. RA Distel R. J., Ro H.-S., Rosen B. S., Groves D. L., Spiegelman B. M. RT Nucleoprotein complexes that regulate gene expression in adipocyte RT differentiation: direct participation of c-fos RL Cell 49:835-844 (1987). XX // AC G000479 XX ID MOUSE$APRT XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD APRT XX DE adenine phosphoribosyltransferase XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.2 XX BS -151 -76 R00052; MOUSE$APRT_01; Binding factors: Sp1 . XX DR EMBL: M11310; MMAPRT. DR TRANSPATH: G000479. DR BRENDA: 2.4.2.7; Mouse. XX RN [1] RX MEDLINE; 88335604. RA Dush M. K., Briggs M. R., Royce M. E., Schaff D. A., Khan S. A., Tischfeld RA J. A., Stambrook P. J. RT Identification of DNA sequences required for mouse APRT gene expression RL Nucleic Acids Res. 16:8509-8524 (1988). XX // AC G000480 XX ID MOUSE$B29 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD B29 XX DE transmembrane glycoprotein B29 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS empty empty R12091; MOUSE$B29_02; Binding factors: NERF-1a . BS -120 0 R01734; MOUSE$B29_01; Binding factors: POU2F1 , BS POU2F2 (Oct-2.1) . XX DR EMBL: AF002279; AF002279. DR EMBL: AL604045; AL604045. DR TRANSPATH: G000480. XX RN [1] RX MEDLINE; 96347578. RA Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T. A. RT Characterization of NERF, a novel transcription factor related to the Ets RT factor ELF-1 RL Mol. Cell. Biol. 16:5091-5106 (1996). RN [2] RX MEDLINE; 90017475. RA Hermanson G. G., Briskin M., Sigman D., Wall R. RT Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific RT gene RL Proc. Natl. Acad. Sci. USA 86:7341-7345 (1989). XX // AC G000481 XX ID MOUSE$BCA XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD BCA XX DE beta-casein XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.5 XX // AC G000483 XX ID MOUSE$B2MG XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD beta2-mg XX DE beta2-microglobulin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -148 -131 R01094; MOUSE$B2MG_01; Binding factors: ICSBP . BS -136 -114 R01095; MOUSE$B2MG_02; Binding factors: KBP-1 , BS NF-kappaB1 , NF-TNF , NF-kappaB1 . XX DR EMBL: M12485; MMMBG2P. DR TRANSPATH: G000483. XX RN [1] RX MEDLINE; 90205817. RA Baldwin jr A. S., LeClair K. P., Singh H., Sharp P. A. RT A large protein containing zinc finger domains binds to related sequence RT elements in the enhancers of the class I major histocompatibility complex RT and kappa immunoglobulin genes RL Mol. Cell. Biol. 10:1406-1414 (1990). RN [2] RX MEDLINE; 90318380. RA Pessara U., Koch N. RT Tumor necrosis factor alpha regulates expression of the major RT histocompatibility complex class II-associated invariant chain by binding RT of an NF-kappaB-like factor to a promoter element RL Mol. Cell. Biol. 10:4146-4154 (1990). RN [3] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [4] RX MEDLINE; 91062349. RA Rustgi A. K., van't Veer L., Bernards R. RT Two genes encode factors with NF-kappaB- and H2TF1-like DNA-binding RT properties RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990). RN [5] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [6] RX MEDLINE; 88111518. RA Yano O., Kanellopoulos J., Kieran M., Le Bail O., Israel A., Kourilsky P. RT Purification of KBF1, a common factor binding to both H-2 and RT beta2-microglobulin enhancers RL EMBO J. 6:3317-3324 (1987). XX // AC G000484 XX ID MOUSE$BMG XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GLOB-BM XX DE betaM-globin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.10.3 XX BS -274 -244 R00540; MOUSE$BMG_01; Binding factors: GATA-1 . BS -255 -245 R03434; MOUSE$BMG_08; Binding factors: NF-1 . BS -219 -204 R00541; MOUSE$BMG_02; Binding factors: GATA-1 . BS -179 -157 R03435; MOUSE$BMG_09. BS -116 0 R00542; MOUSE$BMG_03. BS -86 -66 R03436; MOUSE$BMG_10. BS -80 -66 R00543; MOUSE$BMG_04; Binding factors: GATA-1 . BS -60 -55 R08167; MOUSE$BMG_11; Binding factors: GATA-1 . BS 536 548 R00544; MOUSE$BMG_05; Binding factors: factor B2 , BS GATA-1 . BS 549 567 R00545; MOUSE$BMG_06; Binding factors: factor B1 . BS 667 684 R00546; MOUSE$BMG_07; Binding factors: factor B1 . XX DR EMBL: V00722; MMBGL1. DR EMBL: X00624; MMBGLMAJ. DR EMBL: J05250; MMBGM. DR EMBL: M10829; MMHBBA2. DR EMBL: M17203; MMHBBFL. DR EMBL: J00413; MMHBBMAJ. DR EMBL: M18646; MMHBBTK. DR TRANSPATH: G000484. DR SMARTDB: SM0000144. DR TRRD: 00014. XX RN [1] RA Taxman D. J., Wojchowski D. M. RT Erythropoietin-induced transcription at the murine betamaj-globin promoter RL J. Biol. Chem. 270:6619-6627 (1995). RN [2] RX MEDLINE; 91342631. RA MacLeod K., Plumb M. RT Derepression of mouse beta-major-globin gene transcription during erythroid RT differentiation RL Mol. Cell. Biol. 11:4324-4332 (1991). RN [3] RX MEDLINE; 89343978. RA Barnhart K. M., Kim C. G., Sheffery M. RT Purification and characterization of an erythroid cell-specific factor that RT binds the murine alpha- and beta-globin genes RL Mol. Cell. Biol. 9:2606-2614 (1989). RN [4] RX MEDLINE; 89098433. RA Plumb M., Frampton J., Wainwright H., Walker M., MacLeod K., Goodwin G., RA Harrison P. RT GATAAG; a cis-control region binding an erythroid-specific nuclear factor RT with a role in globin and non-globin gene expression RL Nucleic Acids Res. 17:73-92 (1989). RN [5] RX MEDLINE; 88094410. RA Galson D. L., Housman D. E. RT Detection of Two Tissue-Specific DNA-Binding Proteins with Affinity for RT Sites in the Mouse beta-Globin Intervening Sequence 2 RL Mol. Cell. Biol. 8:381-392 (1988). XX // AC G000485 XX ID MOUSE$CABL1 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD c-abl I XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -270 -241 R02824; MOUSE$CABL1_01; Binding factors: POU2F1a , BS POU5F1 , POU3F1 , POU2F1b , POU2F1c . XX DR EMBL: X07539; MMABLC1A. DR TRANSPATH: G000485. XX RN [1] RX MEDLINE; 91081324. RA Meijer D., Graus A., Kraay R., Langeveld A., Mulder M. P., Grosveld G. RT The octamer binding factor Oct6: cDNA cloning and expression in early RT embryonic cells RL Nucleic Acids Res. 18:7357 (1990). XX // AC G000486 XX ID MOUSE$CFOS XX DT 14.06.1995 (created); dbo. DT 12.11.2001 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD c-fos XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.16 XX BS empty empty R09690; MOUSE$CFOS_11; Binding factors: TFII-I . BS empty empty R09691; MOUSE$CFOS_12; Binding factors: SRF , TFII-I BS . BS empty empty R09692; MOUSE$CFOS_13; Binding factors: TFII-I . BS -322 -305 R09688; MOUSE$CFOS_10. BS -315 -293 R00472; MOUSE$CFOS_01; Binding factors: SRF , SRF BS (504 AA) , YY1 , MHox (K-2) , SRE-ZBP . BS -313 -297 R00473; MOUSE$CFOS_02; Binding factors: factor 1 . BS -309 -295 R00474; MOUSE$CFOS_03; Binding factors: MCM1 . BS -309 -295 R00475; MOUSE$CFOS_04; Binding factors: band I factor BS . BS -178 -144 R10053; MOUSE$CFOS_14; Binding factors: VDR , BS RXR-alpha . BS -151 -130 R00476; MOUSE$CFOS_05; Binding factors: factor 2 . BS -112 -90 R00477; MOUSE$CFOS_06; Binding factors: factor 2 . BS -85 -50 R00478; MOUSE$CFOS_07; Binding factors: factor 3 . BS -71 -40 R00479; MOUSE$CFOS_08; Binding factors: CREB , CRE-BP1 BS . BS 208 220 R01671; MOUSE$CFOS_09. BS 442 481 R11629; MOUSE$CFOS_15; Binding factors: p53 . XX FA T00122; c-Fos. XX DR EMBL: V00727; MMCFOS. DR EMBL: M23768; MMCFOS5F. DR EMBL: J00370; MMFOS. DR EMBL: K03231; MMFOSA. DR TRANSPATH: G000486. DR TRRD: 00107. XX RN [1] RX MEDLINE; 99182446. RA Elkeles A., Juven-Gershon T., Israeli D., Wilder S., Zalcenstein A., Oren M. RT The c-fos proto-oncogene is a target for transactivation by the p53 tumor RT suppressor. RL Mol. Cell. Biol. 19:2594-2600 (1999). RN [2] RX MEDLINE; 98252918. RA Kim D. W., Cheriyath V., Roy A. L., Cochran B. H. RT TFII-I enhances activation of the c-fos promoter through interactions with RT upstream elements RL Mol. Cell. Biol. 18:3310-3320 (1998). RN [3] RA Candeliere G. A., Jurutka P. W., Haussler M. R., St-Arnaud R. RT A composite element binding the vitamin D receptor, retinoid X receptor RT alpha, and a member of the CTF/NF-1 family of transcription factors RT mediates the vitamin D responsiveness of th c-fos promoter RL Mol. Cell. Biol. 16:584-592 (1996). RN [4] RX MEDLINE; 96184854. RA Magnaghi-Jaulin L., Masutani H., Robin P., Lipinski M., Harel-Bellan A. RT SRE elements are binding sites for the fusion protein EWS-FLI-1 RL Nucleic Acids Res. 24:1052-1058 (1996). RN [5] RX MEDLINE; 96025978. RA Natesan S., Gilman M. RT YY1 facilitates the association of serum response factor with the c-fos RT serum response element RL Mol. Cell. Biol. 15:5975-5982 (1995). RN [6] RX MEDLINE; 94086532. RA Aoyagi T., Izumo S. RT Mapping of the pressure response element of the c-fos gene by direct DNA RT injection into beating hearts RL J. Biol. Chem. 268:27176-27179 (1993). RN [7] RX MEDLINE; 93361022. RA MacDonald P. N., Dowd D. R., Nakajima S., Galligan M. A., Reeder M. C., RA Haussler C. A., Ozato K., Haussler M. R. RT Retinoid X receptors stimulate and 9-cis retinoic acid inhibits RT 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene RL Mol. Cell. Biol. 13:5907-5917 (1993). RN [8] RX MEDLINE; 92236619. RA Attar R. M., Gilman M. Z. RT Expression of a novel zinc finger protein that binds to the c-fos serum RT response element RL Mol. Cell. Biol. 12:2432-2443 (1992). RN [9] RX MEDLINE; 91305104. RA Koenig H. RT Cell-type specific multiprotein complex formation over the c-fos serum RT response element in vivo: ternary complex formation is not required for the RT induction of c-fos RL Nucleic Acids Res. 19:3607-3611 (1991). RN [10] RX MEDLINE; 90205810. RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H. RT A cDNA for a human cyclic AMP response element-binding protein which is RT distinct from CREB and expressed preferentially in brain RL Mol. Cell. Biol. 10:1347-1357 (1990). RN [11] RX MEDLINE; 90242394. RA Lamb N. J. C., Fernandez A., Tourkine N., Jeanteur P., Blanchard J.-M. RT Demonstration in living cells of an entragenic negative regulatory element RT within the rodent c-fos gene RL Cell 61:485-496 (1990). RN [12] RX MEDLINE; 89356653. RA Ryan jr W. A., Franza jr B. R., Gilman M. Z. RT Two distinct cellular phospholipoproteins bind to the c-fos serum response RT element RL EMBO J. 8:1785-1792 (1989). RN [13] RX MEDLINE; 90066433. RA Berkowitz L. A., Riabowol K. T., Gilman M. Z. RT Multiple sequence elements of a single functional class are required for RT cyclic AMP responsiveness of the mouse c-fos promoter RL Mol. Cell. Biol. 9:4272-4281 (1989). RN [14] RX MEDLINE; 89184608. RA Levi B.-Z., Kasik J. W., Burke P. A., Prywes R., Roeder R. G., Appella E., RA Ozato K. RT Neonatal induction of a nuclear protein that binds to the c-fos enhancer RL Proc. Natl. Acad. Sci. USA 86:2262-2266 (1989). RN [15] RX MEDLINE; 87089788. RA Gilman M. Z., Wilson R. N., Weinberg R. A. RT Multiple Protein-Binding Sites in the 5'-Flanking Region Regulate c-fos RT Expression RL Mol. Cell. Biol. 6:4305-4316 (1986). XX // AC G000487 XX ID MOUSE$CJUN XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD c-jun XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.16 XX BS empty empty R04032; MOUSE$CJUN_03; Binding factors: c-Fos , BS c-Jun , CREB , JunB , JunD . BS -398 -382 R03060; MOUSE$CJUN_01. BS -329 -293 R03061; MOUSE$CJUN_02. BS -190 -176 R08474; MOUSE$CJUN_05; Binding factors: DRF1 . BS -184 -173 R08475; MOUSE$CJUN_06; Binding factors: DRF2 . BS -59 0 R04219; MOUSE$CJUN_04. XX FA T00131; c-Jun. XX DR EMBL: X57155; MMJUNCPRM. DR TRANSPATH: G000487. XX RN [1] RX MEDLINE; 95354668. RA Kitabayashi I., Eckner R., Arany Z., Chiu R., Gachelin G., Livingston D. RA M., Yokoyama K. K. RT Phosphorylation of the adenovirus E1A-associated 300 kDa Protein in RT response to retinoic acid and E1A during the differentiation of F9 cells RL EMBO J. 14:3496-3509 (1995). RN [2] RX MEDLINE; 93315465. RA Fujihara M., Muroi M., Muroi Y., Ito N., Suzuki T. RT Mechanism of lipopolysaccharide-triggered junB activation in a mouse RT macrophage-like cell line (J774) RL J. Biol. Chem. 268:14898-14905 (1993). RN [3] RX MEDLINE; 93024419. RA Trejo J., Chambard J.-C., Karin M., Brown J. H. RT Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated RT gene transcription: Differential effects of muscarinic and thrombin RT receptor activation RL Mol. Cell. Biol. 12:4742- 4750 (1992). RN [4] RX MEDLINE; 93024390. RA Han T.-H., Lamph W. W., Prywes R. RT Mapping of epidermal growth factor-, serum-, and phorbol ester-responsive RT sequence elements in the c-jun promoter RL Mol. Cell. Biol. 12:4472-4477 (1992). RN [5] RX MEDLINE; 91227153. RA de Groot R. P., Pals C., Kruijer W. RT Transcriptional control of c-jun by retinoic acid RL Nucleic Acids Res. 19:1585-1591 (1991). RN [6] RX MEDLINE; 90272705. RA Lamph W. W., Dwarki V. J., Ofir R., Montminy M., Verma I. M. RT Negative and positive regulation by transcription factor cAMP response RT element-binding protein is modulated by phosphorylation RL Proc. Natl. Acad. Sci. USA 87:4320-4324 (1990). XX // AC G000488 XX ID MOUSE$CMYB XX DT 14.06.1995 (created); dbo. DT 21.11.2000 (updated); sth. CO Copyright (C), Biobase GmbH. XX SD c-myb XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.16 XX BS -277 -263 R09584; MOUSE$CMYB_04; Binding factors: E2F . BS 2010 2024 R01735; MOUSE$CMYB_01. BS 2373 2391 R01737; MOUSE$CMYB_03. BS 2394 2441 R01736; MOUSE$CMYB_02; Binding factors: AP-1 . XX FA T00138; c-Myb. XX DR EMBL: X16389; MMCMYBE1. DR EMBL: M26185; MMCYMB. DR TRANSPATH: G000488. XX RN [1] RX MEDLINE; 20036801. RA Campanero M. R., Armstrong M., Flemington E. RT Distinct cellular factors regulate the c-myb promoter through its E2F RT element RL Mol. Cell. Biol. 19:8442-8450 (1999). RN [2] RX MEDLINE; 90017472. RA Reddy C. D., Reddy E. P. RT Differential binding of nuclear factors to the intron 1 sequences RT containing the transcriptional pause site correlates with c-myb expression RL Proc. Natl. Acad. Sci. USA 86:7326-7330 (1989). XX // AC G000489 XX ID MOUSE$CMYC XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD c-myc XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.16 XX BS empty empty R04524; MOUSE$CMYC_06; Binding factors: CTCF . BS -1101 -1081 R01607; MOUSE$CMYC_03; Binding factors: NF-kappaB(-like) BS . BS -390 0 R02999; MOUSE$CMYC_05; Binding factors: YY1 . BS -295 -271 R01160; MOUSE$CMYC_01; Binding factors: myc-PRF . BS -273 -243 R04796; MOUSE$CMYC_08. BS -263 -254 R01161; MOUSE$CMYC_02; Binding factors: YY1 . BS -71 -63 R08900; MOUSE$CMYC_09; Binding factors: E2F , E2F-1 BS . BS -58 -39 R04622; MOUSE$CMYC_07; Binding factors: MAZ . BS 96 119 R02306; MOUSE$CMYC_04; Binding factors: MAZ . XX FA T00143; c-Myc. XX DR EMBL: X01023; MMCMYC1. DR EMBL: K01866; MMCMYCIB. DR EMBL: K03229; MMCMYCK. DR EMBL: X00195; MMMYCE12. DR EMBL: M12345; MMMYCN. DR TRANSPATH: G000489. DR TRRD: 00108. XX RN [1] RX MEDLINE; 96220465. RA Filippova G. N., Fagerlie S., Klenova E. M., Meyers C., Dehner Y., Goodwin RA G., Neiman P. E., Collins S. J., Lobanenkov V. V. RT An exceptionally conserved transcriptional repressor, CTCF, employs RT different combinations of zinc fingers to bind diverged promoter sequences RT of avian and mammalian c-myc oncogenes RL Mol. Cell. Biol. 16:2802-2813 (1996). RN [2] RX MEDLINE; 94088509. RA Meier V. S., Groner B. RT The nuclear factor YY1 participates in repression of the beta-casein gene RT promoter in mammary epithelial cells and is counteracted by mammary gland RT factor during lactogenic hormone induction RL Mol. Cell. Biol. 14:128- 137 (1994). RN [3] RX MEDLINE; 93376502. RA Numoto M., Niwa O., Kaplan J., Wong K. K., Merrell K., Kamiya K., RA Yanagihara K., Calame K. RT Transcriptional repressor ZF5 identifies a new conserved domain in zinc RT finger proteins RL Nucleic Acids Res. 21:3767-3775 (1993). RN [4] RX MEDLINE; 92366479. RA Bossone St. A., Asselin C., Patel A. J., Marcu K. B. RT MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating RT transcriptional initiation and termination RL Proc. Natl. Acad. Sci. USA 89:7452-7456 (1992). RN [5] RX MEDLINE; 92195674. RA Moberg K. H., Logan T. J., Tyndall W. A., Hall D. J. RT Three distinct elements within the murine c-myc promoter are required for RT transcription RL Oncogene 7:411-421 (1992). RN [6] RX MEDLINE; 92232709. RA Pyrc J. J., Moberg K. H., Hall D. J. RT Isolation of a novel cDNA encoding a zinc-finger protein that binds to two RT sites within the c-myc promoter RL Biochemistry 31:4102-4110 (1992). RN [7] RX MEDLINE; 92017769. RA Baldwin jr A. S., Azizkhan J. C., Jensen D. E., Beg A. A., Coodly L. R. RT Induction of NF-kappaB DNA-binding activity during G0-to-G1 transition in RT mouse fibroblasts RL Mol. Cell. Biol. 11:4943-4951 (1991). RN [8] RX MEDLINE; 91141533. RA Riggs K. J., Merrell K. T., Wilson G., Calame K. RT Common factor 1 is a transcriptional activator which binds in the c.myc RT promoter, the skeletal alpha-actin promoter, and the immunoglobulin RT heavy-chain enhancer RL Mol. Cell. Biol. 11:1765-1769 (1991). RN [9] RX MEDLINE; 90280448. RA Duyao M. P., Buckler A. J., Sonenshein G. E. RT Interaction of an NF-kappaB-like factor with a site upstream of the c-myc RT promoter RL Proc. Natl. Acad. Sci. USA 87:4727-4731 (1990). RN [10] RX MEDLINE; 89295564. RA Kakkis E., Riggs K. J., Gillespie W., Calame K. RT A transcriptional repressor of c-myc RL Nature 339:718-721 (1989). RN [11] RX MEDLINE; 88041045. RA Kakkis E., Calame K. RT A plasmacytoma-specific factor binds the c-myc promoter region RL Proc. Natl. Acad. Sci. USA 84:7031-7035 (1987). XX // AC G000490 XX ID MOUSE$CEBPA XX DT 14.06.1995 (created); dbo. DT 15.11.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD C/EBPalpha XX DE CCAAT/enhancer binding protein alpha XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.2.4 XX BS -334 -314 R08117; MOUSE$CEBPA_05. BS -287 -258 R03132; MOUSE$CEBPA_01; Binding factors: USF-1 . BS -252 -239 R03133; MOUSE$CEBPA_02; Binding factors: CUP . BS -252 -233 R08141; MOUSE$CEBPA_06; Binding factors: Sp1 . BS -203 -176 R03134; MOUSE$CEBPA_03. BS -198 -176 R03135; MOUSE$CEBPA_04; Binding factors: C/EBPalpha . XX FA T00104; C/EBPalpha. XX DR EMBL: M62362; MMCATENB. DR TRANSPATH: G000490. DR TRRD: 00109. XX RN [1] RX MEDLINE; 93261802. RA Legraverend C., Antonson P., Flodby P., Xanthopoulos K. G. RT High level activity of the mouse CCAAT/enhancer binding protein RT (C/EBPalpha) gene promoter involves autoregulation and several ubiquitous RT transcription factors RL Nucleic Acids Res. 21:1735- 1742 (1993). RN [2] RX MEDLINE; 93348263. RA Vasseur-Cognet M., Lane M. D. RT CCAAT/enhancer binding protein alpha (C/EBP alpha) undifferentiated RT protein: a developmentally regulated nuclear protein that binds to the RT C/EBP alpha gene promoter RL Proc. Natl. Acad. Sci. USA 90:7312-7316 (1993). RN [3] RX MEDLINE; 91172853. RA Christy R. J., Kaestner K. H., Geiman D. E., Lane M. D. RT CCAAT/enhancer binding protein gene promoter: binding of nuclear factors RT during differentiation of 3T3-L1 preadipocytes RL Proc. Natl. Acad. Sci. USA 88:2593-2597 (1991). XX // AC G000491 XX ID MOUSE$CD3D XX DT 14.06.1995 (created); dbo. DT 13.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CD3-delta XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.4 XX BS empty empty R04211; MOUSE$CD3D_01; Binding factors: Ik-1 , Ik-2 BS , Ik-3 , Ik-4 , Ik-5 . XX DR EMBL: X12552; MMCD3DEN. DR TRANSPATH: G000491. XX RN [1] RX MEDLINE; 95059058. RA Molnar A., Georgopoulos K. RT The Ikaros gene encodes a family of functionally diverse zinc finger RT DNA-binding proteins RL Mol. Cell. Biol. 14:8292-8303 (1994). XX // AC G000492 XX ID MOUSE$CD4 XX DT 14.06.1995 (created); dbo. DT 09.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CD4 XX DE cell surface glycoprotein XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.4 XX BS -78 -54 R04976; MOUSE$CD4_04; Binding factors: MAZ . BS -55 -31 R04978; MOUSE$CD4_06. BS -20 -4 R04977; MOUSE$CD4_05. BS 18 36 R03469; MOUSE$CD4_01. BS 64 82 R03470; MOUSE$CD4_02; Binding factors: LEF-1 , LEF-1 BS . BS 196 210 R03471; MOUSE$CD4_03; Binding factors: E12 , HEB BS . XX DR EMBL: M17075; MMCD41. DR EMBL: M75688; MMCD4EN. DR TRANSPATH: G000492. XX RN [1] RX MEDLINE; 95280917. RA Duncan D. D., Stupakoff A., Hedrick S. M., Marcu K. B., Siu G. RT A myc-associated zinc finger protein binding site is one of four important RT functional regions inthe CD4 promoter RL Mol. Cell. Biol. 15:3179-3186 (1995). RN [2] RX MEDLINE; 93360996. RA Sawada S., Littman D. R. RT A heterodimer of HEB and an E12-related protein interacts with the CD4 RT enhancer and regulates its activity in T-cell lines RL Mol. Cell. Biol. 13:5620-5628 (1993). RN [3] RX MEDLINE; 92017830. RA Sawada S., Littman D. R. RT Identification and characterization of a T-cell-specific enhancer adjacent RT to the murine CD4 gene RL Mol. Cell. Biol. 11:5506-5515 (1991). XX // AC G000493 XX ID MOUSE$CC4 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD C4 XX DE complement C4 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.6 XX BS empty empty R02464; MOUSE$CC4_01; Binding factors: NF-kappaB(-like) BS . XX DR EMBL: D90167; MMC4. DR EMBL: D90052; MMC4P. DR TRANSPATH: G000493. XX RN [1] RX MEDLINE; 91061734. RA Nonaka M., Huang Z.-M. RT Interleukin-1-mediated enhancement of mouse factor B gene expression via RT NF-kappaB-like hepatoma nuclear factor RL Mol. Cell. Biol. 10:6283-6289 (1990). XX // AC G000494 XX ID MOUSE$CBF XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Bf XX DE complement factor B XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.7.1 XX BS -525 -516 R02463; MOUSE$CBF_01; Binding factors: NF-kappaB(-like) BS . XX DR TRANSPATH: G000494. DR TRRD: 00220. XX RN [1] RX MEDLINE; 91061734. RA Nonaka M., Huang Z.-M. RT Interleukin-1-mediated enhancement of mouse factor B gene expression via RT NF-kappaB-like hepatoma nuclear factor RL Mol. Cell. Biol. 10:6283-6289 (1990). XX // AC G000495 XX ID MOUSE$CHF XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Hf XX DE complement factor H XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.6 XX BS -152 -126 R02856; MOUSE$CHF_01; Binding factors: RAR-beta . XX DR EMBL: M23553; MMMFACH1. DR TRANSPATH: G000495. XX RN [1] RX MEDLINE; 91056035. RA Munoz-Canoves P., Vik D. P., Tack B. F. RT Mapping of a retinoic acid-responsive element in the promoter region of the RT complement factor H gene RL J. Biol. Chem. 265:20065-20068 (1990). XX // AC G000496 XX ID MOUSE$CRABP2 XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD CRABPII XX DE cellular retinoic acid binding protein type II XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -1162 -1141 R03936; MOUSE$CRABP2_02; Binding factors: RXR-alpha BS , RXR-gamma . BS -657 -633 R03935; MOUSE$CRABP2_01; Binding factors: RXR-alpha , BS RXR-gamma . XX DR EMBL: M87538; MMCRAB01. DR EMBL: L01528; MMCRABPII. DR TRANSPATH: G000496. XX RN [1] RX MEDLINE; 93008245. RA Durand B., Saunders M., Leroy P., Leid M., Chambon P. RT All-trans and 9-cis retinoic acid induction of CRABPII transcription is RT mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs RL Cell 71:73-85 (1992). XX // AC G000498 XX ID MOUSE$CYTOP XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CYP1A1 XX DE cytochrome P-450IA1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.9.1 XX BS -1227 -1146 R02649; MOUSE$CYTOP_01; Binding factors: AhR . BS -1076 -1048 R02650; MOUSE$CYTOP_02; Binding factors: AhR . BS -997 -977 R02651; MOUSE$CYTOP_03; Binding factors: AhR , AhR BS , AhR , AhR . BS -933 -869 R02652; MOUSE$CYTOP_04; Binding factors: AhR . BS -893 -641 R02653; MOUSE$CYTOP_05; Binding factors: AhR . BS -509 -448 R02654; MOUSE$CYTOP_06; Binding factors: AhR . XX DR EMBL: M10021; MMCYP14X. DR TRANSPATH: G000498. DR TRRD: 00155. XX RN [1] RX MEDLINE; 94099607. RA Schafer M. W., Madhukar B. V., Swanson H. I., Tullis K., Denison M. S. RT Protein kinase C is not involved in Ah receptor transformation and DNA RT binding RL Arch. Biochem. Biophys. 307:267-271 (1993). RN [2] RX MEDLINE; 94028990. RA Pendurthi U. R., Okino S. T., Tukey R. H. RT Accumulation of the nuclear dioxin (Ah) receptor and transcriptional RT activation of the mouse Cyp1a-1 and Cyp1a-2 genes RL Arch. Biochem. Biophys. 306:65-69 (1993). RN [3] RX MEDLINE; 92195332. RA Carrier F., Owens R. A., Nebert D. W., Puga A. RT Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires RT protein kinase C-dependent phosporylation RL Mol. Cell. Biol. 12:1856-1863 (1992). RN [4] RX MEDLINE; 91056130. RA Elferink C. J., Gasiewicz T. A., Whitlock jr J. P. RT Protein-DNA interactions at a dioxin-responsive enhancer RL J. Biol. Chem. 265:20708-20712 (1990). RN [5] RX MEDLINE; 89380264. RA Denison M. S., Fisher J. M., Whitlock J. P. RT Protein-DNA Interactions at Recognition Sites for the Dioxin-Ah Receptor RT Complex RL J. Biol. Chem. 264:16478-16482 (1989). XX // AC G000499 XX ID MOUSE$CYR61 XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD cyr61 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -1933 -1912 R03375; MOUSE$CYR61_01; Binding factors: SRF . XX DR EMBL: X56790; MMCYR61G. DR TRANSPATH: G000499. DR TRRD: 00229. XX RN [1] RX MEDLINE; 91288203. RA Latinkic B. V., O'Brien T. P., Lau L. F. RT Promoter function and structure of the growth factor-inducible immediate RT early gene cyr61 RL Nucleic Acids Res. 19:3261 (1991). XX // AC G000500 XX ID MOUSE$UCRBP XX DT 21.05.1996 (created); ake. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD UCRBP XX DE UCR binding protein delta, YY1, NF-E1 XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.2.2.4 XX DR TRRD: 00132. XX // AC G000501 XX ID MOUSE$DHFR XX DT 14.06.1995 (created); dbo. DT 10.03.2000 (updated); sth. CO Copyright (C), Biobase GmbH. XX SD DHFR XX DE dihydrofolate reductase XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.2 XX BS empty empty R00281; MOUSE$DHFR_01; Binding factors: Sp1 . BS -217 -40 R00282; MOUSE$DHFR_02; Binding factors: EIIaE-A , Sp1 BS . BS -65 -54 R08817; MOUSE$DHFR_09; Binding factors: E2F . BS -63 -41 R01927; MOUSE$DHFR_07; Binding factors: Sp1 . BS -16 9 R01928; MOUSE$DHFR_08; Binding factors: HIP1 . BS -12 10 R00283; MOUSE$DHFR_03; Binding factors: HIP1 . BS 46 56 R00284; MOUSE$DHFR_04; Binding factors: delta factor . BS 101 116 R00285; MOUSE$DHFR_05. BS 141 154 R00286; MOUSE$DHFR_06. XX DR EMBL: V00735; MMDHF5. DR EMBL: M11419; MMDHFRP. DR EMBL: M13628; MMDHFRPA. DR EMBL: M10071; MMFO5E. DR EMBL: M37144; MMREBC. DR EMBL: M37141; MMREPA. DR EMBL: M37142; MMREPB. DR EMBL: M37143; MMREPC. DR TRANSPATH: G000501. DR BRENDA: 1.5.1.3; Mouse. DR TRRD: 00063. XX RN [1] RX MEDLINE; 99269135. RA Fry C. J., Pearson A., Malinowski E., Bartley S. M., Greenblatt J., Farnham RA P. J. RT Activation of the murine dihydrofolate reductase promoter by E2F1. A RT requirement for CBP recruitment. RL J. Biol. Chem. 274:15883-15891 (1999). RN [2] RX MEDLINE; 97219986. RA Fry C. J., Slansky J. E., Farnham P. J. RT Position-dependent transcriptional regulation of the murine dihydrofolate RT reductase promoter by the E2F transactivation domain RL Mol. Cell. Biol. 17:1966-1976 (1997). RN [3] RX MEDLINE; 92236600. RA Buermeyer A. B., Thompson N. E., Strasheim L. A., Burgess R. R., Farnham P. RA J. RT The HIP1 initiator element plays a role in determining the in vitro RT requirement of the dihydrofolate reductase gene promoter for the C-terminal RT domain of RNA polymerase II RL Mol. Cell. Biol. 12:2250-2259 (1992). RN [4] RX MEDLINE; 92186837. RA Means A. L., Slansky J. E., McMahon S. L., Knuth M. W., Farnham P. J. RT The HIP1 binding site is required for growth regulation of the RT dihydrofolate reductase gene promoter RL Mol. Cell. Biol. 12:1054-1063 (1992). RN [5] RX MEDLINE; 90205815. RA Farnham P. J., Means A. L. RT Sequences downstream of the transcription initiation site modulate the RT actitvity of the murine dihydrofolate reductase promoter RL Mol. Cell. Biol. 10:1390-1398 (1990). RN [6] RX MEDLINE; 90136579. RA Means A. L., Farnham P. G. RT Transcription Initiation from the Dihydrofolate Reductase Promoter Is RT Positioned by HIP1 Binding at the Initiation Site RL Mol. Cell. Biol. 10:653-661 (1990). RN [7] RX MEDLINE; 89313753. RA Atchison M. L., Meyuhas O., Perry R. P. RT Localization of Transcriptional Regulatory Elements and Nuclear Factor RT Binding Sites in Mouse Ribosomal Protein Gene rpL32 RL Mol. Cell. Biol. 9:2067-2074 (1989). RN [8] RX MEDLINE; 86118666. RA Dynan W. S., Sazer S., Tjian R., Schimke R. T. RT Transcription factor Sp1 recognizes a DNA sequence in the mouse RT dihydrofolate reductase promoter RL Nature 319:246-248 (1986). XX // AC G000502 XX ID MOUSE$DPOLB XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD DNA pol B XX DE DNA polymerase beta XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.1 XX BS -1504 -1164 R03643; MOUSE$DPOLB_01. BS -681 -257 R03644; MOUSE$DPOLB_02. XX DR BRENDA: 2.7.7.7; Mouse. DR TRRD: 00437. XX RN [1] RX MEDLINE; 91153982. RA Yamaguchi M., Hayashi Y., Furukawa K., Nishimoto Y., Matsukage A. RT Organization of mouse DNA polymerase beta gene silencer elments and RT identification of the silencer-binding factor(s) RL J. Cancer Res. 82:72-81 (1991). XX // AC G000503 XX ID MOUSE$ECADH XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD CAD1 XX DE E-cadherin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -562 -551 R05102; MOUSE$ECADH_03; Binding factors: HNF-3alpha , BS HNF-3B , FOXM1b , FOXM1a . BS -252 -228 R08809; MOUSE$ECADH_04; Binding factors: LEF-1 . BS -90 -69 R04004; MOUSE$ECADH_01; Binding factors: KER-1 . BS -59 -25 R04005; MOUSE$ECADH_02; Binding factors: Sp1 . XX DR EMBL: M81449; MMCADE. DR EMBL: X60961; MMUVEX1. DR TRANSPATH: G000503. XX RN [1] RX MEDLINE; 97184488. RA Ye H., Kelly T. F., Samadani U., Lim L., Rubio S., Overdier D. G., Roebuck RA K. A., Costa R. H. RT Hepatocyte Nuclear Factor 3/ fork head homolog 11 is expressed in RT proliferating epithelial and mesenchymal cells of embryonic and adult RT tissues RL Mol. Biol. Cell 17:1626-1641 (1997). RN [2] RX MEDLINE; 97047308. RA Huber O., Korn R., McLaughlin J., Ohsugi M., Herrmann B. G., Kemler R. RT Nuclear localization of beta-catenin by interaction with transcription RT factor LEF-1 RL Mech. Dev. 59:3-10 (1996). RN [3] RX MEDLINE; 92107977. RA Behrens J., Loewrick O., Klein-Hitpass L., Birchmeier W. RT The E-cadherin promoter: functional nanlysis of a GC-rich region and an RT epithelial cell-specific palindromic regulatory element RL Proc. Natl. Acad. Sci. USA 88:11495-11499 (1991). XX // AC G000504 XX ID MOUSE$E1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD E1 XX DE embryo stem cell specific enhancer E1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS empty empty R00303; MOUSE$E1_01; Binding factors: POU2F1a , BS POU5F1 , POU2F1b , POU2F1c . BS empty empty R00304; MOUSE$E1_02; Binding factors: POU2F1a , BS POU5F1 , POU2F1b , POU2F1c , POU6F1 . BS empty empty R00305; MOUSE$E1_03; Binding factors: POU2F1a , BS POU5F1 , POU2F1b , POU2F1c . BS empty empty R00306; MOUSE$E1_04; Binding factors: POU2F1a , BS POU5F1 , POU2F1b , POU2F1c . XX DR EMBL: X51834; MMOESTEOP. DR TRANSPATH: G000504. XX RN [1] RX MEDLINE; 94192665. RA Wey E., Lyons G. E., Schaefer B. W. RT A human POU domain gene, mPOU, is expressed in developing brain and RT specific adult tissues RL Eur. J. Biochem. 220:753-762 (1994). RN [2] RX MEDLINE; 91360353. RA Imagawa M., Miyamoto A., Shirakawa M., Hamada H., Muramatsu M. RT Stringent integrity requirements for both trans-activation and DNA-binding RT in a trans-activator, Oct3 RL Nucleic Acids Res. 19:4503-4508 (1991). RN [3] RX MEDLINE; 90150273. RA Okamoto K., Okazawa H., Okuda A., Sakai M., Muramatsu M., Hamada H. RT A novel octamer binding transcription factor is differentially expressed in RT mouse embryonic cells RL Cell 60:461-472 (1990). XX // AC G000505 XX ID MOUSE$EGR1 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Egr-1 XX DE early growth response factor 1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.2.4 XX BS empty empty R09704; MOUSE$EGR1_07; Binding factors: SRF . BS -661 -634 R01614; MOUSE$EGR1_01; Binding factors: Egr-1 , Egr-1 BS . BS -603 -583 R01615; MOUSE$EGR1_02; Binding factors: Egr-1 , WT1 BS , Egr-1 . BS -412 -391 R01797; MOUSE$EGR1_06; Binding factors: SRF , SRF BS (504 AA) . BS -358 -337 R01796; MOUSE$EGR1_05; Binding factors: SRF . BS -279 0 R01616; MOUSE$EGR1_03; Binding factors: Egr-1 , Egr-1 BS . BS -88 -67 R01795; MOUSE$EGR1_04; Binding factors: SRF . XX DR EMBL: X12617; MMEGR1A. DR EMBL: M22326; MMTFEZIF. DR TRANSPATH: G000505. DR TRANSCOMPEL: C00126. DR TRRD: 00305. XX RN [1] RX MEDLINE; 20400505. RA Bernal-Mizrachi E., Wice B., Inoue H., Permutt M. A. RT Activation of serum response factor in the depolarization induction of RT Egr-1 transcription in pancreatic islet beta-cells RL J. Biol. Chem. 275:25681-25689 (2000). RN [2] RX MEDLINE; 94253095. RA Thiel G., Schoch S., Petersohn D. RT Regulation of synapsin I gene expression by the zinc finger transcription RT factor zif268/egr-1 RL J. Biol. Chem. 269:15294-15301 (1994). RN [3] RX MEDLINE; 90318391. RA Gius D., Cao X., Rauscher III F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are Independent Functions: RT The C Terminus Represses Immediate-Early Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). RN [4] RX MEDLINE; 91057660. RA Rauscher F. J., Morris F. J., Tournay O. E., Cook D. M., Curran T. RT Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 RT consensus sequence RL Science 250:1259-1262 (1990). RN [5] RX MEDLINE; 90220577. RA Cao X., Koski R. A., Gashler A., McKiernan M., Morris C. F., Gaffney R., RA Hay R. V., Sukhatme V. P. RT Identfication and characterization of the Egr-1 gene product, a DNA-binding RT zinc finger protein induced by differentiation and growth signals RL Mol. Cell. Biol. 10:1931-1939 (1990). RN [6] RX MEDLINE; 90097904. RA Christy B., Nathans D. RT Functional Serum Response Elements Upstream of the Growth Factor-Inducible RT Gene zif268 RL Mol. Cell. Biol. 9:4889-4895 (1989). RN [7] RX MEDLINE; 90046868. RA Christy B., Nathans D. RT DNA binding site of the growth factor-inducible protein Zif268 RL Proc. Natl. Acad. Sci. USA 86:8737-8741 (1989). XX // AC G000506 XX ID MOUSE$EAII XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD EAII XX DE elastase II XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.7.1 XX BS -156 -134 R00407; MOUSE$EAII_01. BS -123 -99 R00408; MOUSE$EAII_02. BS -91 -68 R00409; MOUSE$EAII_03; Binding factors: PTF1-beta . BS -83 -68 R00410; MOUSE$EAII_04. XX DR EMBL: X04576; MMELA2G. DR TRANSPATH: G000506. DR BRENDA: 3.4.21.71. XX RN [1] RX MEDLINE; 89343964. RA Cockell M., Stevenson B. J., Strubin M., Hagenbuechle O., Wellauer P. K. RT Identification of a Cell-Specific DNA-Binding Activity That Interacts with RT a Transcriptional Activator of Genes Expressed in the Acinar Pancreas RL Mol. Cell. Biol. 9:2464-2476 (1989). XX // AC G000507 XX ID MOUSE$EPOR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD EpoR XX DE erythropoietin receptor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.15 XX BS -201 -193 R03347; MOUSE$EPOR_03; Binding factors: GATA-1 . BS -199 -194 R02890; MOUSE$EPOR_01; Binding factors: GATA-1 . BS -173 -159 R03348; MOUSE$EPOR_04; Binding factors: Sp1 . BS -171 -166 R02891; MOUSE$EPOR_02; Binding factors: Sp1 , Sp1 BS . XX DR EMBL: M38133; MMERPRA. DR EMBL: X53081; MMERYPR. DR TRANSPATH: G000507. DR TRRD: 00324. XX RN [1] RX MEDLINE; 92256246. RA Ito E., Toki T., Arai K., Kawauchi K., Tsuda H., Yokoyama M. RT Expression of a lineage specific transcriptional factor GATA-1 in leukaemic RT blasts from patients with infantile leukaemia RL Br. J. Haematol. 80:561-563 (1992). RN [2] RX MEDLINE; 91319540. RA Chiba T., Ikawa Y., Todokoro K. RT GATA-1 transactivates erythropoietin receptor gene, and erythropoietin RT receptor-mediated signals enhance GATA-1 gene expression RL Nucleic Acids Res. 19:3843-3848 (1991). RN [3] RX MEDLINE; 92073342. RA Zon L. I., Youssoufian H., Mather C., Lodish H. F., Orkin S. H. RT Activation of the erythropoietin receptor promoter by transcription factor RT GATA-1 RL Proc. Natl. Acad. Sci. USA 88:10638-10641 (1991). XX // AC G000509 XX ID MOUSE$FOSB XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD fosB XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5 XX BS -428 -419 R08490; MOUSE$FOSB_01; Binding factors: SRF (504 AA) . XX DR TRANSPATH: G000509. DR TRRD: 00028. XX RN [1] RX MEDLINE; 92158623. RA Lazo P. S., Dorfman K., Noguchi T., Mattei M. G., Bravo R. RT Structure and mapping of the fosB gene. FosB downregulates the activity of RT the fosB promoter RL Nucleic Acids Res. 20:343-350 (1992). XX // AC G000510 XX ID MOUSE$GCSF XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD G-CSF XX DE granulocyte colony stimulating factor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.9 XX BS -186 -161 R00600; MOUSE$GCSF_01; Binding factors: C/EBPgamma . XX DR EMBL: M34155; MMGCSFP. DR TRANSPATH: G000510. XX RN [1] RX MEDLINE; 91224353. RA Nishizawa M., Wakabayashi-Ito N., Nagata S. RT Molecular cloning of cDNA and a cromosomal gene encoding GPE1-BP, a nuclear RT protein which binds to granulocyte colony-stimulating fator promoter RT element 1 RL FEBS Lett. 1:95-97 (1991). RN [2] RX MEDLINE; 90220584. RA Nishizawa M., Nagata S. RT Regulatory Elements Responsible for Inducible Expression of the Granulocyte RT Colony-Stimulating Factor Gene in Macrophages RL Mol. Cell. Biol. 10:2002-2011 (1990). XX // AC G000511 XX ID MOUSE$GFCR XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD CRY-gammaF XX DE gammaF-crystallin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.9 XX BS -207 -190 R03963; MOUSE$GFCR_02; Binding factors: RAR-alpha1 , BS RXR-beta2 , RORalpha1 . BS -67 -25 R03015; MOUSE$GFCR_01. XX DR EMBL: M11039; MMCRYG2D. DR TRANSPATH: G000511. XX RN [1] RX MEDLINE; 95378274. RA Tini M., Fraser R. A., Giguere V. RT Functional interactions between retinoic acid receptor-related orphan RT nuclear receptor (RORalpha) and the retinoic acid receptors in the RT regulation of the gammaF-crystallin promoter RL J. Biol. Chem. 270:20156-20161 (1995). RN [2] RX MEDLINE; 93170668. RA Tini M., Otulakowski G., Breitman M. L., Tsui L.-C., Giguere V. RT An everted repeat mediates retinoic acid induction of the gammaF-crystallin RT gene: evidence of a direct role for retinoids in lens development RL Genes Dev. 7:295-307 (1993). RN [3] RX MEDLINE; 91141502. RA Liu Q., Tini M., Tsui L.-C., Breitman M. L. RT Interaction of a lens cell transcription factor with the proximal domain of RT the mouse gammaF-crystallin promoter RL Mol. Cell. Biol. 11:1531-1537 (1991). XX // AC G000512 XX ID MOUSE$GATA1 XX DT 14.06.1995 (created); dbo. DT 20.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD GATA1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.2 XX BS -687 -673 R03213; MOUSE$GATA1_01; Binding factors: GATA-1 . BS -220 0 R03214; MOUSE$GATA1_02. BS -198 -190 R03215; MOUSE$GATA1_03. XX DR EMBL: X56854; MMGATAEX1. DR TRANSPATH: G000512. DR TRRD: 00327. XX RN [1] RX MEDLINE; 96189105. RA Trainor C. D., Omichinski J. G., Vandergon T. L., Gronenborn A. M., Clore RA G. M., Felsenfeld G. RT A palindromic regulatory site within vertebtrate GATA-1 promoters requires RT both zinc fingers of the GATA-1 DNA-binding domain for high-affinity RT interaction RL Mol. Cell. Biol. 16:2238-2247 (1996). RN [2] RX MEDLINE; 91257579. RA Tsai S.-F., Strauss E., Orkin S. H. RT Functional analysis and in vivo footprinting implicate the erythroid RT transcription factor GATA-1 as a positive regulator of its own promoter RL Genes Dev. 5:919-931 (1991). RN [3] RX MEDLINE; 92020218. RA Nicolis S., Bertini C., Ronchi A., Crotta S., Lanfranco L., Moroni E., RA Giglioni B., Ottolenghi S. RT An erythroid specific enhancer upstream to the gene encoding the cell-type RT specific transcription factor GATA-1 RL Nucleic Acids Res. 19:5285-5291 (1991). XX // AC G000513 XX ID MOUSE$GFAP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GFAP XX DE glial fibrillary acidic protein XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.6 XX BS -162 -140 R02863; MOUSE$GFAP_01; Binding factors: CREB , BS CREBbeta . BS -123 -104 R02864; MOUSE$GFAP_02; Binding factors: NF-1 . BS -103 -82 R02865; MOUSE$GFAP_03. XX DR EMBL: X02801; MMGFAPD. DR TRANSPATH: G000513. XX RN [1] RA Miura M., Tamura T.-A., Mikoshiba K. RT Involvement of the nuclear factor I motif in the mouse myelin protein RT promoter in cell-specific regulation: comparison with the mouse glial RT fibrillary acidic protein promoter RL Develop. Growth & Differ. 33:111-116 (1991). XX // AC G000514 XX ID MOUSE$GLUT4 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GLUT4 XX DE insulin-responsive glucose transporter XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.1.2 XX BS -266 -241 R01700; MOUSE$GLUT4_01; Binding factors: C/EBPalpha . BS -171 -151 R01701; MOUSE$GLUT4_02; Binding factors: Sp1 . BS -134 -112 R01702; MOUSE$GLUT4_03; Binding factors: Sp1 . BS -110 -87 R01703; MOUSE$GLUT4_04. BS -84 -55 R01704; MOUSE$GLUT4_05; Binding factors: Sp1 . XX DR EMBL: M29660; MMGT4. DR TRANSPATH: G000514. DR TRRD: 00029. XX RN [1] RX MEDLINE; 90115850. RA Kaestner K. H., Christy R. J., Lane M. D. RT Mouse insulin-responsive glucose transporter gene: Characterization of the RT gene and trans-activation by the CCAAT/enhancer binding protein RL Proc. Natl. Acad. Sci. USA 87:251-255 (1990). XX // AC G000515 XX ID MOUSE$GSR XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GSr XX DE glutamine synthase, retrotransposon-like gene XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4 XX BS -985 -950 R03291; MOUSE$GSR_01. BS -235 -210 R03292; MOUSE$GSR_02. BS -200 -170 R03293; MOUSE$GSR_03. BS -130 -80 R03294; MOUSE$GSR_04. XX DR EMBL: M60803; MMGSA. DR BRENDA: 6.3.1.2. XX RN [1] RX MEDLINE; 91210303. RA Bhandari B., Roesler W. J., DeLisio K. D., Klemm D. J., Ross N. S., Miller RA R. E. RT A functional promoter flanks an intronless glutamine synthetase gene RL J. Biol. Chem. 266:7784-7792 (1991). XX // AC G000516 XX ID MOUSE$GST XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GST-Ya XX DE glutathione S-transferase Ya subunit XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.9.2 XX BS -783 -728 R02339; MOUSE$GST_01; Binding factors: AhR . XX DR EMBL: M19250; MMGSTYA1. DR TRANSPATH: G000516. DR BRENDA: 2.5.1.18; Mouse. DR TRRD: 00268. XX RN [1] RX MEDLINE; 90349594. RA Friling R. Sh., Bensimon A., Tichauer Y., Daniel V. RT Xenobiotic-inducible expression of murine glutathione S-transferase Ya RT subunit gene is controlled by an electrophile-responsive element RL Proc. Natl. Acad. Sci. USA 87:6258-6262 (1990). XX // AC G000517 XX ID MOUSE$GMCSF XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD GM-CSF XX DE granulocyte/macrophage colony stimulating factor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.9 XX BS -108 -98 R00605; MOUSE$GMCSF_01; Binding factors: NF-kappaB . BS -91 -82 R00606; MOUSE$GMCSF_02; Binding factors: NF-kappaB . BS -90 -82 R01733; MOUSE$GMCSF_03; Binding factors: GM-PBP-1 . BS -63 -33 R04064; MOUSE$GMCSF_04; Binding factors: ELF-1 , BS NF-CLE0a , NF-CLE0b . BS -60 -33 R05095; MOUSE$GMCSF_05; Binding factors: AP-1 . BS -60 -33 R05096; MOUSE$GMCSF_06; Binding factors: NFAT-1 . BS -55 -27 R12070; MOUSE$GMCSF_07; Binding factors: Elf-1 . XX DR EMBL: X03020; MMGMCSFG. DR TRANSPATH: G000517. DR TRANSCOMPEL: C00081. DR TRANSCOMPEL: C00108. DR TRANSCOMPEL: C00156. XX RN [1] RX MEDLINE; 96257231. RA Davis J. N., Roussel M. F. RT Cloning and expression of the murine Elf-1 cDNA RL Gene 171:265-269 (1996). RN [2] RX MEDLINE; 93262492. RA Wang C.-Y., Petryniak B., Thompson C. B., Kaelin W. G., Leiden J. M. RT Regulation of the Ets-related transcription factor Elf-1 by binding to the RT retinoblastoma protein RL Science 260:1330-1335 (1993). RN [3] RX MEDLINE; 94067100. RA Masuda E. S., Tokumitsu H., Tsuboi A., Shlomai J., Hung P., Arai K.-I., RA Arai N. RT The granulocyte-macrophage colony-stimulating factor promoter cis-acting RT element CLE0 mediates induction signals in T cells and is recognized by RT factors related to AP1 and NFAT. RL Mol. Cell. Biol. 13:7399-7407 (1993). RN [4] RX MEDLINE; 92049315. RA Miyatake S., Shlomai J., Arai K.-I., Arai N. RT Characterization of the mouse granulocyte-macrophage colony-stimulating RT factor (GM-CSF) gene promoter: nuclear factors that interact with an RT element shared by three lymphokine genes -- those for GM-CSF, interleukin-4 RT (IL-4), and IL-5 RL Mol. Cell. Biol. 11:5894-5901 (1991). RN [5] RX MEDLINE; 90158596. RA Schreck R., Baeuerle P. A. RT NF-kappaB as inducible transcriptional activator of the RT granulocyte-macrophage colony-stimulating factor gene RL Mol. Cell. Biol. 10:1281-1286 (1990). RN [6] RX MEDLINE; 90017485. RA James R., Kazenwadel J. RT T-cell nuclei contain a protein that binds upstream of the murine RT granulocyte-macrophage colony-stimulating factor gene RL Proc. Natl. Acad. Sci. USA 86:7392-7396 (1989). XX // AC G000518 XX ID MOUSE$GBP1 XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Gbp-1 XX DE guanylate-binding protein-1 XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5 XX DR TRRD: 00231. XX // AC G000519 XX ID MOUSE$GUS XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD Gus XX DE beta-glucuronidase XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.8 XX BS 7990 8046 R03466; MOUSE$GUS_01. XX DR EMBL: J02836; MMGUSB01. DR BRENDA: 3.2.1.31; Mouse. XX RN [1] RX MEDLINE; 92017821. RA Lund S. D., Gallagher P. M., Wang B., Porter S. C., Ganschow R. E. RT Androgen responsiveness of the murine beta-glucuronidase gene is associated RT with nuclease hypersensitivity, protein binding, and haplotype-specific RT sequence diversity within intron 9 RL Mol. Cell. Biol. 11:5426-5434 (1991). XX // AC G000523 XX ID MOUSE$FCGR1 XX DT 21.05.1996 (created); ake. DT 21.05.1996 (updated); ake. CO Copyright (C), Biobase GmbH. XX SD Fc gamma RI XX DE high affinity IgG receptor XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5 XX DR TRRD: 00230. XX // AC G000524 XX ID MOUSE$HH10 XX DT 21.05.1996 (created); ake. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H1(0) XX DE histone 1 zero XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.1.1 XX BS -549 -529 R04761; MOUSE$HH10_01; Binding factors: RAR-alpha1 , BS RAR-gamma , RAR-beta , RXR-alpha . XX DR EMBL: U18295; MM18295. DR EMBL: M29260; MMHIS10P. DR TRANSPATH: G000524. DR TRRD: 00232. XX RN [1] RX MEDLINE; 94358882. RA Mader S., Thiele K., Breuer B., Alonso A. RT The promoter of the H1ª histone gene contains a DNA element bound by RT retinoic acid receptors RL J. Mol. Biol. 242:37-44 (1994). XX // AC G000525 XX ID MOUSE$HOXA5 XX DT 14.06.1995 (created); dbo. DT 11.05.2000 (updated); rio. CO Copyright (C), Biobase GmbH. XX SD HOXA5 XX DE homeobox gene 5 on HOX cluster A XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -156 -142 R02635; MOUSE$HOXA5_01; Binding factors: HOXA5 . BS -128 -99 R02636; MOUSE$HOXA5_02; Binding factors: HOXA5 . BS -95 -75 R02637; MOUSE$HOXA5_03; Binding factors: HOXA5 . BS 332 346 R08925; MOUSE$HOXA5_04. BS 352 373 R08926; MOUSE$HOXA5_05. BS 376 389 R08927; MOUSE$HOXA5_06. XX DR EMBL: Y00208; MMHOX13. DR TRANSPATH: G000525. XX RN [1] RX MEDLINE; 99177148. RA Nowling T., Zhou W., Krieger K. E., Larochelle C., Nguyen-Huu M. C., RA Jeannotte L., Tuggle C. K. RT Hoxa5 gene regulation: A gradient of binding activity to a brachial spinal RT cord element RL Dev. Biol. 208:134-146 (1999). RN [2] RX MEDLINE; 89232713. RA Odenwald W. F., Garbern J., Arnheiter H., Tournier-Lasserve E., Lazzarini RA R. A. RT The HOX-1.3 homeo box protein is a sequence-specific DNA-binding RT phosphoprotein RL Genes Dev. 3:158-172 (1989). XX // AC G000526 XX ID MOUSE$HOX14 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Hox-1.4 XX DE homeobox gene 1.4 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -237 -214 R00721; MOUSE$HOX14_01; Binding factors: Krox-20 , BS Krox-24 . BS -200 -181 R00722; MOUSE$HOX14_02. XX DR EMBL: X66861; MMHOX14B. DR TRANSPATH: G000526. XX RN [1] RX MEDLINE; 90214631. RA Chavrier P., Vesque C., Galliot B., Vigneron M., Dolle P., Duboule D., RA Charnay P. RT The segment-specific gene Krox-20 encodes a transcription factor with RT binding sites in the promoter region of the Hox-1.4 gene RL EMBO J. 9:1209-1219 (1990). RN [2] RX MEDLINE; 90287135. RA Lemaire P., Vesque C., Schmitt J., Stunnenberg H., Frank R., Charnay P. RT The serum-inducible mouse gene Krox-24 encodes a sequence-specific RT transcriptional activator RL Mol. Cell. Biol. 10:3456-3467 (1990). XX // AC G000527 XX ID MOUSE$HOX15 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Hox-1.5 XX DE homeobox gene 1.5 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS empty empty R00723; MOUSE$HOX15_01; Binding factors: HOXA3 . XX DR TRANSPATH: G000527. XX RN [1] RX MEDLINE; 87092283. RA Fainsod A., Bogarad L. D., Ruusala T., Lubin M., Crothers D. M., Ruddle F. RA H. RT The homeo domain of a murine protein binds 5' to its own homeo box RL Proc. Natl. Acad. Sci. USA 83:9532-9536 (1986). XX // AC G000528 XX ID MOUSE$HOX23 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Hox-2.3 XX DE homeobox gene 2.3 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -1430 -1394 R02083; MOUSE$HOX23_01. BS -1268 -1254 R02084; MOUSE$HOX23_02. BS -1211 -1190 R02085; MOUSE$HOX23_03; Binding factors: Krox-20 , BS Sp1 . BS -1154 -1140 R02086; MOUSE$HOX23_04. BS -1061 -889 R02087; MOUSE$HOX23_05. BS -92 -67 R02088; MOUSE$HOX23_06. BS -66 -54 R02089; MOUSE$HOX23_07. BS -53 -32 R02090; MOUSE$HOX23_08; Binding factors: USF-1 , USF-1 BS . BS 61 83 R02091; MOUSE$HOX23_09. XX DR EMBL: Y00436; MMHOX23. DR EMBL: X06762; MMHOX23R. DR TRANSPATH: G000528. XX RN [1] RX MEDLINE; 91322033. RA Zwartkruis F., Hoeijmakers T., Deschamps J., Meijlink F. RT Characterization of the murine Hox-2.3 promoter: involvement of the RT transcription factor USF (MLTF) RL Mech. Dev. 33:179-190 (1991). XX // AC G000529 XX ID MOUSE$HSP70 XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD hsp70 XX DE heat shock protein 70 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.2 XX BS -118 -98 R03464; MOUSE$HSP70_01; Binding factors: HSF , HSF2 BS . XX DR EMBL: M76613; MMHP7A2. DR TRANSPATH: G000529. XX RN [1] RX MEDLINE; 92009180. RA Sarge K. D., Zimarino V., Holm K., Wu C., Morimoto R. I. RT Cloning and characterization of two mouse heat shock factors with distinct RT inducible and constitutive DNA-binding ability RL Genes Dev. 5:1902-1911 (1991). XX // AC G000530 XX ID MOUSE$HTF9 XX DT 14.06.1995 (created); dbo. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD HTF9-A XX DE RANBP1: Ran binding protein 1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.7.4 XX BS -120 -101 R09826; MOUSE$HTF9_05. BS 796 812 R03360; MOUSE$HTF9_01. BS 838 852 R03361; MOUSE$HTF9_02; Binding factors: Sp1 . BS 858 871 R03362; MOUSE$HTF9_03. BS 914 923 R03428; MOUSE$HTF9_04. XX DR EMBL: X05830; MMHTF9. DR TRANSPATH: G000530. DR TRRD: 00448. XX RN [1] RX MEDLINE; 99214597. RA Di Fiore B., Guarguaglini G., Palena A., Kerkhoven R. M., Bernards R., RA Lavia P. RT Two E2F sites control growth-regulated and cell cycle-regulated RT transcription of the Htf9-a/RanBP1 gene through functionally distinct RT mechanisms RL J. Biol. Chem. 274:10339-10348 (1999). RN [2] RX MEDLINE; 91279430. RA Somma M. P., Pisano C., Lavia P. RT The housekeeping promoter from the mouse CpG island HTF9 contains multiple RT protein-binding elements that are functionally redundant RL Nucleic Acids Res. 19:2817 (1991). RN [3] RX MEDLINE; 91360345. RA Somma M. P., Gambino I., Lavia P. RT Transcription factors binding to the mouse HTF9 housekeeping promoter RT differ between cell types RL Nucleic Acids Res. 19:4451-4458 (1991). XX // AC G000531 XX ID MOUSE$IAP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IAP LTR XX DE intracisternal A-particle XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.2.1.1 XX BS -189 -171 R04776; MOUSE$IAP_05; Binding factors: YY1 . BS -167 -137 R01693; MOUSE$IAP_01. BS -142 -127 R01694; MOUSE$IAP_02; Binding factors: Sp1 . BS -129 -113 R02896; MOUSE$IAP_03; Binding factors: EBP-80 . BS -59 -43 R04186; MOUSE$IAP_04. XX DR EMBL: M62768; MMANTRVL1. DR EMBL: M17551; MMFLIAP. DR TRANSPATH: G000531. XX RN [1] RX MEDLINE; 94019335. RA Satyamoorthy K., Park K., Atchison M. L., Howe C. C. RT The intracisternal A-particle upstream element interacts with transcription RT factor YY1 to activate transcription: pleiotropic effects of YY1 on RT distinct DNA promoter elements RL Mol. Cell. Biol. 13:6621-6628 (1993). RN [2] RX MEDLINE; 93024428. RA Lamb B. T., Satyamoorthy K., Solter D., Basu A., Xu M. Q., Weinmann R., RA Howe C. C. RT A DNA element that regulates expression of an endogenous retrovirus during RT F9 cell differentiation is E1A dependent RL Mol. Cell. Biol. 12:4824- 4833 (1992). RN [3] RX MEDLINE; 91094822. RA Falzon M., Kuff E. L. RT Binding of the transcription factor EBP-80 mediates the methylation RT response of an intracisternal A-particle long terminal repeat promoter RL Mol. Cell. Biol. 11:117-125 (1991). RN [4] RX MEDLINE; 90094375. RA Falzon M., Kuff E. L. RT Isolation and Characterization of a Protein Fraction That Binds to Enhancer RT Core Sequences in Intracisternal A-particle Long Terminal Repeats RL J. Biol. Chem. 264:21915-21922 (1989). XX // AC G000532 XX ID MOUSE$ICER XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD ICER XX DE inducible cAMP early repressor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -154 -123 R03925; MOUSE$ICER_01; Binding factors: CREMtau , BS ICER-II , ICER-IIgamma , CREMtaualpha , CREMtau1 BS , CREMtau2 , ICER-II , ICER-IIgamma . BS -123 -92 R03926; MOUSE$ICER_02; Binding factors: CREMtau , BS ICER-II , ICER-IIgamma , CREMtaualpha , CREMtau1 BS , CREMtau2 , ICER-II , ICER-IIgamma . XX DR EMBL: S67785; S67785. DR TRANSPATH: G000532. XX RN [1] RX MEDLINE; 94073967. RA Molina C. A., Foulkes N. S., Lalli E., Sassone-Corsi P. RT Inducibility and negative autoregulation of CREM: an alternative promoter RT directs the expression of ICER, an early response repressor RL Cell 75:875-886 (1993). XX // AC G000533 XX ID MOUSE$IL2 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IL-2 XX DE interleukin-2 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.9 XX BS -285 -269 R02348; MOUSE$IL2_01; Binding factors: NFAT-1 , Pu BS box binding factor , NF-ATp , NF-ATc , NF-ATx BS , NF-ATp , NF-AT3 . BS -285 -269 R05036; MOUSE$IL2_09; Binding factors: AP-1 , c-Fos BS , c-Jun , Fra-1 . BS -235 -213 R03696; MOUSE$IL2_06; Binding factors: AP-3 (2) , BS TCF-1(P) , TCF-2 . BS -215 -191 R02951; MOUSE$IL2_03; Binding factors: AP-3 (2) , BS NF-kappaB , TCF-1(P) , TCF-2 , TCF-3 . BS -165 -141 R02952; MOUSE$IL2_04; Binding factors: AP-1 , c-Jun BS , Fra-1 . BS -165 -141 R05049; MOUSE$IL2_10; Binding factors: NF-ATp , BS NF-ATc , NF-ATx , NF-ATp , NF-AT3 . BS -156 0 R03697; MOUSE$IL2_07; Binding factors: AP-3 (2) , BS TCF-1(P) , TCF-2 . BS -138 -121 R02349; MOUSE$IL2_02; Binding factors: Pu box binding factor BS , NF-ATp , NF-ATc , NF-ATx , NF-ATp BS , NF-AT3 . BS -138 -121 R05050; MOUSE$IL2_11; Binding factors: AP-1 , c-Jun BS , Fra-1 . BS -112 0 R03698; MOUSE$IL2_08; Binding factors: AP-3 (2) , BS TCF-1(P) , TCF-2 . BS -96 -64 R02953; MOUSE$IL2_05; Binding factors: AP-1 , POU2F1 BS , POU2F2 . BS -95 -79 R05051; MOUSE$IL2_12; Binding factors: NF-ATp , NF-ATc BS , NF-ATx , NF-ATp , NF-AT3 . BS -95 -79 R05052; MOUSE$IL2_13; Binding factors: AP-1 , c-Jun BS , FosB , JunB , Fra-1 . BS -52 -44 R05053; MOUSE$IL2_14; Binding factors: NF-ATp , NF-ATc BS , NF-ATx , NF-ATp , NF-AT3 . XX DR EMBL: X14473; MMENHIL2. DR EMBL: X52618; MMIL25RR. DR TRANSPATH: G000533. DR TRANSCOMPEL: C00149. DR TRANSCOMPEL: C00150. DR TRANSCOMPEL: C00151. DR TRANSCOMPEL: C00157. DR TRANSCOMPEL: C00158. XX RN [1] RX MEDLINE; 98169066. RA Chen L., Glover J. N. M., Hogan P. G., Rao A., Harrison S. C. RT Structure of the DNA-binding domains from NFAT, Fos and Jun bound RT specifically to DNA. RL Nature 392:42-48 (1998). RN [2] RX MEDLINE; 96026011. RA Rooney J. W., Sun Y.-L., Glimcher L. H., Hoey T. RT Novel NFAT sites that mediate activation of the interleukin-2 promoter in RT response to T-cell receptor stimulation RL Mol. Cell. Biol. 15:6299-6310 (1995). RN [3] RX MEDLINE; 95081605. RA Pfeuffer I., Klein-Hessling S., Heinfling A., Chuvpilo S., Escher C., RA Brabletz T., Hentsch B., Schwarzenbach H., Matthias P., Serfling E. RT Octamer factors exert a dual effect on the IL-2 and IL-4 promoters RL J. Immunol. 153:5572-5585 (1994). RN [4] RX MEDLINE; 93329079. RA Jain J., Miner Z., Rao A. RT Analysis of the preexisting and nuclear forms of Nuclear Factor of RT Activated T cells RL J. Immunol. 151:837-848 (1993). RN [5] RX MEDLINE; 92244343. RA Jain J., McCaffrey P. G., Valge-Archer V. E., Rao A. RT Nuclear factor of activated T cells contain Fos and Jun RL Nature 356:801-804 (1992). RN [6] RX MEDLINE; 92318932. RA Kang S.-M., Tsang W., Doll S., Scherle P., Ko H.-S., Tran A.-C., Lenardo M. RA J., Staudt L. M. RT Induction of the POU domain transcription factor Oct-2 during T-cell RT activation by cognate antigen RL Mol. Cell. Biol. 12:3149-3154 (1992). RN [7] RX MEDLINE; 91224091. RA Mouzaki A., Weil R., Muster L., Rungger D. RT Silencing and trans-activation of the mouse IL-2 gene in Xenopus oocytes by RT proteins from resting and mitogen-induced primary T-lymphocytes RL EMBO J. 10:1399-1406 (1991). RN [8] RX MEDLINE; 91187650. RA Brabletz T., Pietrowski I., Serfling E. RT The immunosuppressives FK 506 and cyclosporin A inhibit the generation of RT protein factors binding to the two purine boxes of the interleukin 2 RT enhancer RL Nucleic Acids Res. 19:61-67 (1991). RN [9] RX MEDLINE; 92051383. RA Briegel K., Hentsch B., Pfeuffer I., Serfling E. RT One base pair change abolishes the T cell-restricted activity of a kB-like RT proto-enhancer element from the interleukin 2 promoter RL Nucleic Acids Res. 19:5292-5936 (1991). RN [10] RX MEDLINE; 90316111. RA Randak Ch., Brabletz Th., Hergenroether M., Sobotta I., Serfling E. RT Cyclosporin A suppresses the expression of the interleukin 2 gene by RT inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer RL EMBO J. 9:2529-2536 (1990). XX // AC G000534 XX ID MOUSE$IL4 XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD IL-4 XX DE interleukin-4 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.9 XX BS -252 -228 R08174; MOUSE$IL4_08. BS -189 -166 R08173; MOUSE$IL4_07. BS -176 -144 R08172; MOUSE$IL4_06. BS -92 -57 R05081; MOUSE$IL4_05; Binding factors: HMG I(Y) , HMG BS I(Y) . BS -88 -79 R05079; MOUSE$IL4_03; Binding factors: AP-1 , c-Fos BS , c-Jun , Fra-1 , JunB , JunD , BS Fra-2 . BS -75 -61 R05080; MOUSE$IL4_04; Binding factors: NFAT-1 , NF-ATp BS , NF-ATc . BS -69 -40 R04080; MOUSE$IL4_01; Binding factors: NF-CLE0a , BS NF-CLE0b . BS -59 -27 R04775; MOUSE$IL4_02; Binding factors: c-Maf , NF-ATp BS . XX DR EMBL: X05064; MMIL4G12. DR EMBL: S69237; S69237. DR EMBL: S69238; S69238. DR TRANSPATH: G000534. DR TRANSCOMPEL: C00159. DR TRANSCOMPEL: C00162. DR TRANSCOMPEL: C00167. XX RN [1] RX MEDLINE; 97456880. RA Takemoto N., Koyano-Nakagawa N., Arai N., Arai K.-I., Yokota T. RT Four P-like elements are required for optimal transcription of the mouse RT IL-4 gene: involvement of a distinct set of nuclear factor of activated T RT cells and activator protein-1 family proteins RL Int. Immunol. 9:1329-1338 (1997). RN [2] RX MEDLINE; 97140327. RA Klein-Hessling S., Schneider G., Heinfling A., Chuvpilo S., Serfling E. RT HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction RT of the interleukin 4 promoter in T cells RL Proc. Natl. Acad. Sci. USA 93:15311-15315 (1996). RN [3] RX MEDLINE; 96270501. RA Ho I-C., Hodge M. R., Rooney J. W., Glimcher L. H. RT The proto-oncogene c-maf is responsible for tissue-specific expression of RT interleukin-4 RL Cell 85:973-983 (1996). RN [4] RX MEDLINE; 95269131. RA Rooney J. W., Hoey T., Glimcher L. H. RT Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of RT the murine IL-4 gene RL Immunity 2:473-483 (1995). RN [5] RX MEDLINE; 92049315. RA Miyatake S., Shlomai J., Arai K.-I., Arai N. RT Characterization of the mouse granulocyte-macrophage colony-stimulating RT factor (GM-CSF) gene promoter: nuclear factors that interact with an RT element shared by three lymphokine genes -- those for GM-CSF, interleukin-4 RT (IL-4), and IL-5 RL Mol. Cell. Biol. 11:5894-5901 (1991). XX // AC G000535 XX ID MOUSE$IL5 XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD IL-5 XX DE interleukin-5 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.9 XX BS -117 -92 R05097; MOUSE$IL5_02; Binding factors: NF-ATp , BS NF-ATc , NF-ATx . BS -117 -92 R05098; MOUSE$IL5_03; Binding factors: AP-1 , AP-1 BS . BS -88 -77 R08263; MOUSE$IL5_05. BS -73 -54 R08264; MOUSE$IL5_06; Binding factors: GATA-3 . BS -53 -39 R04079; MOUSE$IL5_01; Binding factors: c-Fos , JunB BS , JunD , NF-CLE0a , NF-CLE0b . BS -30 -16 R08262; MOUSE$IL5_04. XX DR EMBL: D14461; MM4K. DR TRANSPATH: G000535. DR TRANSCOMPEL: C00161. XX RN [1] RX MEDLINE; 95340553. RA Lee H. J., Masuda E. S., Arai N., Arai K.-I., Yokota T. RT Definition of cis-regulatory elements of the mouse interleukin-5 gene RT promoter RL J. Biol. Chem. 270:17541-17550 (1995). RN [2] RX MEDLINE; 96025854. RA Siegel M. D., Zhang D.-H., Ray P., Ray A. RT Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells RT requires the GATA-3 and CLE0 elements RL J. Biol. Chem. 270:24548-24555 (1995). RN [3] RX MEDLINE; 92049315. RA Miyatake S., Shlomai J., Arai K.-I., Arai N. RT Characterization of the mouse granulocyte-macrophage colony-stimulating RT factor (GM-CSF) gene promoter: nuclear factors that interact with an RT element shared by three lymphokine genes -- those for GM-CSF, interleukin-4 RT (IL-4), and IL-5 RL Mol. Cell. Biol. 11:5894-5901 (1991). XX // AC G000536 XX ID MOUSE$IL7R XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD IL-7R XX DE interleukin-7 receptor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.15 XX BS -286 -237 R03126; MOUSE$IL7R_01; Binding factors: IRF1 , IRF-2 BS . XX DR TRANSPATH: G000536. XX RN [1] RX MEDLINE; 91246172. RA Pleiman C. M., Gimpel S. D., Park L. S., Harada H., Taniguchi T., Ziegler RA S. F. RT Organization of the murine and human interleukin-7 receptor genes: two RT mRNAs generated by differential splicing and presence of a type RT I-interferon-inducible promoter RL Mol. Cell. Biol. 11:3052-3059 (1991). XX // AC G000537 XX ID MOUSE$IGH XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IgH XX DE immunoglobulin heavy chain XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.1.1 XX BS empty empty R00845; MOUSE$IGH_11. BS empty empty R00872; MOUSE$IGH_38; Binding factors: NF-A , POU2F1 BS , POU2F1a , POU2F1 , NF-A , NF-A , BS POU2F1b , POU2F1c . BS empty empty R01834; MOUSE$IGH_43; Binding factors: POU2F2 (Oct-2.1) BS . BS empty empty R04158; MOUSE$IGH_59; Binding factors: E47 , ITF-2 BS , myogenin , Tal-1 , Tal-1beta , HEB BS , NF-X3 , Tal-1 , Tal-1 . BS empty empty R11185; MOUSE$IGH_63; Binding factors: MafK , Bach2 BS . BS empty empty R12089; MOUSE$IGH_65; Binding factors: NERF-1a . BS empty empty R12090; MOUSE$IGH_64; Binding factors: NERF-1a . BS -547 -424 R03520; MOUSE$IGH_48. BS -250 -125 R03521; MOUSE$IGH_49. BS -154 54 R00835; MOUSE$IGH_01; Binding factors: NF-A . BS -132 -104 R03912; MOUSE$IGH_57. BS -123 1 R00836; MOUSE$IGH_02. BS -121 -107 R00837; MOUSE$IGH_03; Binding factors: C/EBPalpha , BS C/EBPgamma . BS -111 -83 R03911; MOUSE$IGH_56; Binding factors: ATF-1 . BS -83 -60 R00840; MOUSE$IGH_06; Binding factors: C/EBPgamma . BS -73 -44 R00841; MOUSE$IGH_07; Binding factors: POU2F2 , POU2F2 BS , POU2F2B , POU2F2 (Oct-2.1) , POU2F2 (Oct-2.3) BS , POU2F2 (Oct-2.4) , POU2F2 (Oct-2.6) , POU2F2 BS (Oct-2.1) , POU2F2B . BS -73 -42 R00842; MOUSE$IGH_08; Binding factors: POU2F1 , POU2F2 BS . BS -73 -42 R00843; MOUSE$IGH_09; Binding factors: POU2F1 . BS -70 -59 R01683; MOUSE$IGH_41; Binding factors: NTF . BS -63 -41 R01682; MOUSE$IGH_40; Binding factors: POU2F1 , POU2F2 BS (Oct-2.1) . BS -56 -50 R00838; MOUSE$IGH_04; Binding factors: POU2F1 . BS -56 -50 R00839; MOUSE$IGH_05; Binding factors: POU2F2 (Oct-2.1) BS . BS -43 -29 R00844; MOUSE$IGH_10; Binding factors: muEBP-C2 , BS TFE3-S . BS -40 -19 R03882; MOUSE$IGH_54. BS -5 8 R03883; MOUSE$IGH_55. BS 176 200 R03633; MOUSE$IGH_50; Binding factors: NF-muNR . BS 285 333 R03634; MOUSE$IGH_51; Binding factors: NF-muNR . BS 321 520 R00846; MOUSE$IGH_12; Binding factors: muEBP-B , BS muEBP-C2 , C/EBPgamma . BS 321 340 R00847; MOUSE$IGH_13; Binding factors: C/EBPalpha , BS C/EBPgamma . BS 344 368 R04900; MOUSE$IGH_62; Binding factors: delta factor . BS 346 360 R00848; MOUSE$IGH_14; Binding factors: NF-muE1 , YY1 BS , YY1 . BS 378 437 R00849; MOUSE$IGH_15; Binding factors: IgPE-1 . BS 378 391 R00850; MOUSE$IGH_16; Binding factors: E47 , INSAF BS , MyoD , myogenin , Tal-1 , HEB , BS Tal-1 , Tal-1 . BS 380 433 R04065; MOUSE$IGH_58; Binding factors: c-Ets-1 68 . BS 390 412 R00851; MOUSE$IGH_17. BS 392 438 R00852; MOUSE$IGH_18. BS 396 408 R01787; MOUSE$IGH_42; Binding factors: YEB3 . BS 397 415 R00853; MOUSE$IGH_19; Binding factors: GT-IIBalpha , BS NF-muE3 , TFE3-L , TFE3 , TFE3-S , USF1 BS , USF-1 , NFdeltaE3C , NF-muE3 , USF-1 BS . BS 410 430 R02685; MOUSE$IGH_47; Binding factors: LyF-1 , PU.1 BS , PU.1 . BS 424 442 R04332; MOUSE$IGH_60; Binding factors: core-binding factor BS . BS 439 461 R00854; MOUSE$IGH_20. BS 448 479 R04333; MOUSE$IGH_61; Binding factors: core-binding factor BS . BS 456 626 R00855; MOUSE$IGH_21; Binding factors: NF-A . BS 467 485 R00856; MOUSE$IGH_22; Binding factors: C/EBPgamma . BS 477 486 R00857; MOUSE$IGH_23. BS 497 518 R00858; MOUSE$IGH_24; Binding factors: IgPE-2 . BS 518 529 R00859; MOUSE$IGH_25. BS 518 563 R01884; MOUSE$IGH_44; Binding factors: POU2F1a , BS Oct-10 , POU2F2 , POU5F1 , POU3F3 , Oct-9 BS , POU2F1b , POU2F1c , POU2F2 (Oct-2.1) , BS POU2F2 (Oct-2.3) , POU2F2 (Oct-2.4) , POU2F2 (Oct-2.6) BS , POU2F2 (Oct-2.1) , POU3F2 . BS 518 563 R01885; MOUSE$IGH_45; Binding factors: POU2F1a , BS POU5F1 , POU5F1 (Oct-5) , POU3F1 , POU2F1b BS , POU2F1c . BS 518 563 R01886; MOUSE$IGH_46; Binding factors: POU2F1a , BS POU5F1 , POU2F1b , POU2F1c . BS 523 536 R00860; MOUSE$IGH_26. BS 526 555 R00861; MOUSE$IGH_27; Binding factors: POU2F2 , BS POU2F2B , POU2F2C , POU2F2B . BS 526 555 R00862; MOUSE$IGH_28; Binding factors: POU2F1 , POU2F2 BS . BS 526 555 R00863; MOUSE$IGH_29. BS 526 555 R00864; MOUSE$IGH_30; Binding factors: POU2F1a , BS POU5F1 , POU5F1 (Oct-5) , POU2F1 , POU2F1b BS , POU2F1c . BS 531 563 R00865; MOUSE$IGH_31. BS 532 553 R00866; MOUSE$IGH_32. BS 532 564 R00867; MOUSE$IGH_33. BS 534 566 R00868; MOUSE$IGH_34; Binding factors: IgPE-3 . BS 541 0 R00871; MOUSE$IGH_37. BS 542 548 R00869; MOUSE$IGH_35; Binding factors: POU2F1 . BS 542 548 R00870; MOUSE$IGH_36; Binding factors: POU2F1a , BS POU2F2 , POU2F2 , POU5F1 (Oct-5) , POU3F1 , BS POU2F2B , POU2F1b , POU2F1c , POU2F2 (Oct-2.1) BS , POU2F2 (Oct-2.3) , POU2F2 (Oct-2.4) , POU2F2 BS (Oct-2.6) , POU2F2 (Oct-2.1) . BS 573 576 R00873; MOUSE$IGH_39. BS 732 753 R03635; MOUSE$IGH_52; Binding factors: NF-muNR . BS 788 826 R03636; MOUSE$IGH_53; Binding factors: NF-muNR . XX DR EMBL: X03571; MMIG10VH. DR EMBL: V01523; MMIG33. DR EMBL: V01524; MMIG34. DR EMBL: J00440; MMIGCD07. DR EMBL: M35180; MMIGCT. DR EMBL: J00516; MMIGHAB2. DR EMBL: J00519; MMIGHAE. DR EMBL: M12827; MMIGHEAA. DR EMBL: M15020; MMIGHEL. DR EMBL: M15022; MMIGHEN. DR EMBL: M15023; MMIGHEO. DR EMBL: M12421; MMIGHGH. DR EMBL: X53774; MMIGHJ14. DR EMBL: M17898; MMIGHPRO. DR EMBL: J00538; MMIGHVN3. DR EMBL: M15010; MMIGHWY. DR EMBL: M15011; MMIGHWZ. DR EMBL: M15012; MMIGHXA. DR EMBL: M15014; MMIGHXC. DR EMBL: M15015; MMIGHXD. DR EMBL: M15016; MMIGHXE. DR EMBL: M15018; MMIGHXG. DR EMBL: M15019; MMIGHXH. DR EMBL: M16723; MMIGHYK. DR EMBL: M16724; MMIGHYL. DR EMBL: X01435; MMIGMUV2. DR EMBL: X01436; MMIGMUV3. DR EMBL: X06856; MMIGVH23. DR EMBL: X02460; MMIGVH7. DR EMBL: X01832; MMIGVNP1. DR EMBL: S74164; MS164. DR TRANSPATH: G000537. DR TRANSCOMPEL: C00031. DR TRANSCOMPEL: C00032. DR TRANSCOMPEL: C00035. DR TRANSCOMPEL: C00049. DR TRANSCOMPEL: C00133. DR TRANSCOMPEL: C00170. DR TRANSCOMPEL: C00171. DR TRANSCOMPEL: C00252. DR TRANSCOMPEL: C00253. DR TRANSCOMPEL: C00258. DR SMARTDB: SM0000044. DR SMARTDB: SM0000045. DR SMARTDB: SM0000136. DR SMARTDB: SM0000221. DR SMARTDB: SM0000222. DR SMARTDB: SM0000223. XX RN [1] RX MEDLINE; 98429496. RA Muto A., Hoshino H., Madisen L., Yanai N., Obinata M., Karasuyama H., RA Hayashi N., Nakauchi H., Yamamoto M., Groudine M., Igarashi K. RT Identification of Bach2 as a B-cell-specific partner for small maf proteins RT that negatively regulate the immunoglobulin heavy chain gene 3' enhancer RL EMBO J. 17:5734-5743 (1998). RN [2] RX MEDLINE; 96347578. RA Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T. A. RT Characterization of NERF, a novel transcription factor related to the Ets RT factor ELF-1 RL Mol. Cell. Biol. 16:5091-5106 (1996). RN [3] RX MEDLINE; 95303615. RA Panagiotidis C. A., Artandi S., Calame K., Silverstein S. J. RT Polyamines alter sequence-specific DNA-protein interactions RL Nucleic Acids Res. 23:1800-1809 (1995). RN [4] RX MEDLINE; 94119077. RA Hsu H.-L., Huang L., Tsan J. T., Funk W., Wright W. E., Hu J.-S., Kingston RA R. E., Baer R. RT Preferred sequences for DNA recognition by the TAL1 helix-loop-helix RT proteins RL Mol. Cell. Biol. 14:1256-1265 (1994). RN [5] RX MEDLINE; 94088509. RA Meier V. S., Groner B. RT The nuclear factor YY1 participates in repression of the beta-casein gene RT promoter in mammary epithelial cells and is counteracted by mammary gland RT factor during lactogenic hormone induction RL Mol. Cell. Biol. 14:128- 137 (1994). RN [6] RX MEDLINE; 94286557. RA Perez J. R., Li Y., Stein C. A., Majumder S., van Oorschot A. RT Sequence-independent induction of Sp1 trasncription factor activity by RT phosphorothioate oligodeoxynucleotides RL Proc. Natl. Acad. Sci. USA 91:5957-5961 (1994). RN [7] RX MEDLINE; 93303626. RA Nelsen B., Tian G., Erman B., Gregoire J., Maki R., Graves B., Sen R. RT Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer RT by Ets-domain proteins RL Science 261:82-86 (1993). RN [8] RX MEDLINE; 93017905. RA Lin Y.-C. A., Stavnezer J. RT Regulation of transcription of the germ-line Igalpha constant region gene RT by an ATF element and by novel transforming growth factor-beta1-responsive RT elements RL J. Immunol. 149:2914-2925 (1992). RN [9] RX MEDLINE; 92123207. RA Roman C., Matera A. G., Cooper C., Artandi S., Blain S., Ward D. C., Calame RA K. RT mTFE3, an X-linked transcriptional activator containing basic RT helix-loop-helix and zipper domains, utilizes the zipper to stabilize both RT DNA binding and multimerization RL Mol. Cell. Biol. 12:817-827 (1992). RN [10] RX MEDLINE; 92107201. RA Wang S., Speck N. A. RT Purification of core-binding factor, a protein that binds the conserved RT core site in murine leukemia virus enhancers RL Mol. Cell. Biol. 12:89-102 (1992). RN [11] RX MEDLINE; 92186835. RA Hu J.-S., Olson E. N., Kingston R. E. RT HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate RT the DNA-binding ability of myogenic regulatory factors RL Mol. Cell. Biol. 12:1031-1042 (1992). RN [12] RX MEDLINE; 92236613. RA Voliva C. F., Aronheim A., Walker M. D., Peterlin B. M. RT B-cell factor 1 is required for optimal expression of the DRA promoter in B RT cells RL Mol. Cell. Biol. 12:2383-2390 (1992). RN [13] RX MEDLINE; 92078144. RA Parvin J. D., Sharp P. A. RT Identification of novel factors which bind specifically to the core RT promoter of the immunoglobulin heavy chain gene RL J. Biol. Chem. 266:22878-22886 (1991). RN [14] RX MEDLINE; 92017799. RA Lo K., Landau N. R., Smale S. T. RT LyF-1, a transcriptional regulator that interacts with a novel class of RT promoters for lymphocytes-specific genes RL Mol. Cell. Biol. 11:5229-5243 (1991). RN [15] RX MEDLINE; 91141533. RA Riggs K. J., Merrell K. T., Wilson G., Calame K. RT Common factor 1 is a transcriptional activator which binds in the c.myc RT promoter, the skeletal alpha-actin promoter, and the immunoglobulin RT heavy-chain enhancer RL Mol. Cell. Biol. 11:1765-1769 (1991). RN [16] RX MEDLINE; 91246170. RA Hsu H.-L., Cheng J.-T., Chen Q., Baer R. RT Enhancer-binding activity of the tal-1 oncoprotein in association with the RT E47/E12 helix-loop-helix proteins RL Mol. Cell. Biol. 11:3037-3042 (1991). RN [17] RX MEDLINE; 91342667. RA Kuhn R., Monuki E. S., Lemke G. RT The gene encoding the transcription factor SCIP has features of an RT expressed retroposon RL Mol. Cell. Biol. 11:4642-4650 (1991). RN [18] RX MEDLINE; 92017848. RA Redondo J. M., Pfohl J. L., Krangel M. S. RT Identification of an essential site for transcriptional activation within RT the human T-cell receptor delta enhancer RL Mol. Cell. Biol. 11:5671-5680 (1991). RN [19] RX MEDLINE; 92017795. RA Webb C. F., Das C., Eaton S., Calame K., Tucker P. W. RT Novel protein-DNA interactions associated with increased immunoglobulin RT transcription in response to antigen plus interleukin-5 RL Mol. Cell. Biol. 11:5197-5205 (1991). RN [20] RX MEDLINE; 92051390. RA Chen U., Scheuermann R. H., Wirth T., Gerstler T., Roeder R. G., Harshman RA K., Berger C. RT Anti-IgM antibodies down modulate mu-enhacer activity and OTF2 levels in RT LPS-stimulated mouse splenic B-cells RL Nucleic Acids Res. 19:5981-5989 (1991). RN [21] RX MEDLINE; 92052179. RA Park K., Atchison M. L. RT Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that RT binds to the immunoglobulin kappa 3 enhancer and the immunoglobulin RT heavy-chain muE1 site RL Proc. Natl. Acad. Sci. USA 88:9804-9808 (1991). RN [22] RX MEDLINE; 92049349. RA Wilson R. B., Kiledjian M., Shen C.-P., Benezra R., Zwollo P., Dymecki S. RA M., Desiderio S. V., Kadesch T. RT Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: RT implications for B-lymphoid-cell development RL Mol. Cell. Biol. 11:6185-6191 (1991). RN [23] RX MEDLINE; 90228363. RA Mueller-Immerglueck M. M., Schaffner W., Matthias P. RT Transcription factor Oct-2A contains functionally redundant activating RT domains and works selectively from a promoter but not from a remote RT enhancer position in non-lymphoid (HeLa) cells RL EMBO J. 9:1625-1634 (1990). RN [24] RX MEDLINE; 90151654. RA Elmaleh N., Matthias P., Schaffner W. RT A factor known to bind to the endogenous Ig heavy chain enhancer only in RT lymphocytes is a ubiquitously active transcription factor RL Eur. J. Biochem. 187:507-513 (1990). RN [25] RX MEDLINE; 90249724. RA Beckmann H., Su L.-K., Kadesch T. RT TFE3: a helix-loop-helix protein that activates transcription through the RT immunoglobulin enhancer E3 motif RL Genes Dev. 4:167-179 (1990). RN [26] RX MEDLINE; 91032992. RA Roman C., Platero J. S., Shuman J., Clamae K. RT Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein RT that is similar to C/EBP and heterodimerizes with C/EBP RL Genes Dev. 4:1404-1415 (1990). RN [27] RX MEDLINE; 90158614. RA Johnson D. G., Carayannopoulos L., Capra J. D., Tucker P. W., Hanke J. H. RT The ubiquitous octamer-binding protein(s) is sufficient for transcription RT of immunoglobulin genes RL Mol. Cell. Biol. 10:982-990 (1990). RN [28] RX MEDLINE; 90258906. RA Nelsen B., Kadesch T., Sen R. RT Complex Regulation of the Immunoglobulin mu Heavy-Chain Gene Enhancer: muB, RT a New Determinant of Enhancer Function RL Mol. Cell. Biol. 10:3145-3154 (1990). RN [29] RX MEDLINE; 90258907. RA Libermann T. A., Lenardo M., Baltimore D. RT Involvement of a Second Lymphoid-Specific Enhancer Element in the RT Regulation of Immunoglobulin Heavy-Chain Gene Expression RL Mol. Cell. Biol. 10:3155-3162 (1990). RN [30] RX MEDLINE; 90206045. RA Schoeler H. R., Ruppert S., Suzuki N., Chowdhury K., Gruss P. RT New type of POU domain in germ line-specific protein Oct-4 RL Nature 344:435-439 (1990). RN [31] RX MEDLINE; 90206774. RA Walker M. D., Park C. W., Rosen A., Aronheim A. RT A cDNA from a mouse pancreatic beta cell encoding a putative transcription RT factor of the insulin gene RL Nucleic Acids Res. 18:1159-1166 (1990). RN [32] RX MEDLINE; 91016834. RA Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W., Fontana A. RT Astrocytes and glioblastoma cells express novel octamer-DNA binding RT proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins RL Nucleic Acids Res. 18:5495-5503 (1990). RN [33] RX MEDLINE; 90138945. RA Petryniak B., Staudt L. M., Postema C. A., McCormack W. T., Thompson C. B. RT Characterization of chicken octamer-binding proteins demonstrates that POU RT domain-containing homeobox transcription factors have been highly conserved RT during vertebrate evolution RL Proc. Natl. Acad. Sci. USA 87:1099-1103 (1990). RN [34] RX MEDLINE; 90332686. RA Chellappan S. P., Nevins J. R. RT DNA octamer element can confer E1A trans-activation, and adenovirus RT infection results in a stimulation of the DNA-binding activity of RT OTF-1/NFIII factor RL Proc. Natl. Acad. Sci. USA 87:5878-5882 (1990). RN [35] RX MEDLINE; 90291983. RA Schoeler H. R., Dressler G. R., Balling R., Rohdewohld H., Gruss P. RT Oct-4: a germline-specific transcription factor mapping to the mouse RT t-complex RL EMBO J. 9:2185-2195 (1990). RN [36] RX MEDLINE; 90220600. RA Yoza B. K., Roeder R. G. RT Identification of a novel factor that interacts with an immunoglobulin RT heavy-chain promoter and stimulates transcription in conjunction with the RT lymphoid cell-specific factor OTF2 RL Mol. Cell. Biol. 10:2145-2153 (1990). RN [37] RX MEDLINE; 90005405. RA Kemler I., Schreiber E., Mueller M. M., Matthias P., Schaffner W. RT Octamer transcription factors bind to two different sequence motifs of the RT heavy chain promoter RL EMBO J. 8:2001-2008 (1989). RN [38] RX MEDLINE; 90060013. RA Schoeler H. R., Hatzopoulos A. K., Balling R., Suzuki N., Gruss P. RT A family of octamer-specific proteins present during mouse embryogenesis: RT evidence for germline-specific expression of an Oct factor RL EMBO J. 8:2543-2550 (1989). RN [39] RX MEDLINE; 90060014. RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P. RT Octamer binding proteins confer transcriptional activity in early mouse RT embryogenesis RL EMBO J. 8:2551-2557 (1989). RN [40] RX MEDLINE; 90128262. RA LeBowitz J. H., Clerc R. G., Brenowitz M., Sharp P. A. RT The Oct-2 protein binds cooperatively to adjacent octamer sites RL Genes Dev. 3:1625-1638 (1989). RN [41] RX MEDLINE; 90006747. RA Scheuermann R. H., Chen U. RT A developmental-specific factor binds to suppressor sites flanking the RT immunglobulin heavy-chain enhancer RL Genes Dev. 3:1255-1266 (1989). RN [42] RX MEDLINE; 89219069. RA Poellinger L., Roeder R. G. RT Octamer transcription factors 1 and 2 each bind to two different functional RT elements in the immunoglobulin heavy-chain promoter RL Mol. Cell. Biol. 9:747-756 (1989). RN [43] RX MEDLINE; 89219072. RA Peterson C. L., Calame K. RT Proteins Binding to Site C2 (muE3) in the Immunoglobulin Heavy-Chain RT Enhancer Exist in Multiple Oligomeric Forms RL Mol. Cell. Biol. 9:776-786 (1989). RN [44] RX MEDLINE; 90066465. RA Beckmann H., Kadesch T. RT Identification of a Yeast Protein with Properties Similar to Those of the RT Immunoglobulin Heavy-Chain Enhancer-Binding Protein NF-muE3 RL Mol. Cell. Biol. 9:4535-4540 (1989). RN [45] RX MEDLINE; 89183596. RA Pruijn G. J. M., van der Vliet P. C., Dathan N. A., Mattaj I. W. RT Anti-OTF-1 antibodies inhibit NFIII stimulation of in vitro adenovirus DNA RT replication RL Nucleic Acids Res. 17:1845-1863 (1989). RN [46] RX MEDLINE; 89366697. RA Schreiber E., Matthias P., Mueller M. M., Schaffner W. RT Rapid detection of octamer binding proteins with mini-extracts, prepared RT from a small number of cells RL Nucleic Acids Res. 17:6419 (1989). RN [47] RX MEDLINE; 89264585. RA Reith W., Barras E., Satola S., Kobr M., Reinhardt D., Sanchez C. H., Mach RA B. RT Cloning of the major histocompatibility complex class II promoter binding RT protein affected in a hereditary defect in class II gene regulation RL Proc. Natl. Acad. Sci. USA 86:4200-4204 (1989). RN [48] RX MEDLINE; 89210808. RA Schreiber E., Matthias P., Mueller M. M., Schaffner W. RT Identification of a novel lymphoid specific octamer binding protein RT (OTF-2B) by proteolytic clipping bandshift assay (PCBA) RL EMBO J. 7:4221-4229 (1988). RN [49] RX MEDLINE; 89091990. RA Baumruker T., Sturm R., Herr W. RT OBP100 binds remarkably degenerate octamer motifs through specific RT interactions with flanking sequences RL Genes Dev. 2:1400-1413 (1988). RN [50] RX MEDLINE; 89107993. RA Sturm R. A., Das G., Herr W. RT The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a RT homeo box subdomain RL Genes Dev. 2:1582-1599 (1988). RN [51] RX MEDLINE; 89078997. RA LeBowitz J. H., Kobayashi T., Staudt L., Baltimore D., Sharp P. A. RT Octamer-binding proteins from B or HeLa cells stimulate transcription of RT the immunoglobulin heavy-chain promoter in vitro RL Genes Dev. 2:1227-1237 (1988). RN [52] RX MEDLINE; 89096871. RA Peterson C. L., Eaton S., Calame K. RT Purified muEBP-E Binds to Immunoglobulin Enhancers and Promoters RL Mol. Cell. Biol. 8:4972-4980 (1988). RN [53] RX MEDLINE; 89070675. RA Scheidereit C., Cromlish J. A., Gerster T., Kawakami K., Balmaceda C.-G., RA Currie R. A., Roeder R. G. RT A human lymphoid-specific transcription factor that activates RT immunoglobulin genes is a homeobox protein RL Nature 336:551-557 (1988). RN [54] RX MEDLINE; 89070674. RA Mueller M. M., Ruppert S., Schaffner W., Matthias P. RT A cloned octamer transcription factor stimulates transcription from RT lymphoid-specific promoters in non-B cells RL Nature 336:544-551 (1988). RN [55] RX MEDLINE; 88233920. RA Tsao B. P., Wang X.-F., Peterson C. L., Calame K. RT In vivo functional analysis of in vitro protein binding sites in the RT immunoglobulin heavy chain enhancer RL Nucleic Acids Res. 16:3239-3253 (1988). RN [56] RX MEDLINE; 88217941. RA Hanke J. H., Landolfi N. F., Tucker P. W., Capra J. D. RT Identification of murine nuclear proteins that bind to the conserved RT octamer sequence of the immunoglobulin promoter region RL Proc. Natl. Acad. Sci. USA 85:3560-3564 (1988). RN [57] RX MEDLINE; 88111566. RA Pruijn G. J. M., van Driel W., van Miltenburg R. T., van der Vliet P. C. RT Promoter and enhancer elements containing a conserved sequence motif are RT recognized by nuclear factor III, a protein stimulating adenovirus DNA RT replication RL EMBO J. 6:3771-3778 (1987). RN [58] RX MEDLINE; 88082672. RA Xiao J. H., Davidson I., Ferrandon D., Rosales R., Vigneron M., Macchi M., RA Ruffenach F., Chambon P. RT One cell-specific and three ubiquitous proteins bind in vitro to RT overlapping motifs in the domain B1 of the SV40 enhancer RL EMBO J. 6:3005-3013 (1987). RN [59] RX MEDLINE; 88112794. RA Sturm R., Baumruker T., Franza jr B. R., Herr W. RT A 100-kD HeLa cell octamer binding protein (OBP100) interacts differently RT with two separate octamer-related sequences within the SV40 enhancer RL Genes Dev. 1:1147-1160 (1987). RN [60] RX MEDLINE; 88142808. RA Peterson C. L., Calame K. L. RT Complex Protein Binding within the Mouse Immunoglobulin Heavy-Chain Enhancer RL Mol. Cell. Biol. 7:4194-4203 (1987). RN [61] RX MEDLINE; 87115775. RA Bohmann D., Keller W., Dale T., Schoeler H. R., Tebb G., Mattaj I. W. RT A transcription factor which binds to the enhancers of SV40, immunoglobulin RT heavy chain and U2 snRNA genes RL Nature 325:268-272 (1987). RN [62] RX MEDLINE; 86298399. RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). RN [63] RX MEDLINE; 87133485. RA Schlokat U., Bohmann D., Schoeler H., Gruss P. RT Nuclear factors binding specific sequences within the immunoglobulin RT enhancer interact differentially with other enhancer elements RL EMBO J. 5:3251-3258 (1986). RN [64] RX MEDLINE; 87004545. RA Augereau P., Chambon P. RT The mouse immunoglobulin heavy chain enhancer: effect on transcription in RT vitro and binding of proteins present in HeLa and lymphoid B cell extracts RL EMBO J. 5:1791-1797 (1986). RN [65] RX MEDLINE; 87089772. RA Peterson C. L., Orth K., Calame K. L. RT Binding In Vitro of Multiple Cellular Proteins to Immunoglobulin RT Heavy-Chain Enhancer DNA RL Mol. Cell. Biol. 6:4168-4178 (1986). RN [66] RX MEDLINE; 86092241. RA Singh H., Sen R., Baltimore D., Sharp P. A. RT A nuclear factor that binds to a conserved sequence motif in RT transcriptional control elements of immunoglobulin genes RL Nature 319:154-158 (1986). RN [67] RX MEDLINE; 87039335. RA Staudt L. M., Singh H., Sen R., Wirth T., Sharp P. A., Baltimore D. RT A lymphoid-specific protein binding to the octamer motif of immunoglobulin RT genes RL Nature 323:640-643 (1986). RN [68] RX MEDLINE; 87014826. RA Landolfi N. F., Capra J. D., Tucker P. W. RT Interaction of cell-type-specific nuclear proteins within immunoglobulin VH RT promoter region sequences RL Nature 323:548-551 (1986). RN [69] RX MEDLINE; 86311318. RA Weinberger J., Baltimore D., Sharp P. A. RT Distinct factors bind to apparently homologous sequences in the RT immunoglobulin heavy-chain enhancer RL Nature 322:846-848 (1986). RN [70] RX MEDLINE; 87014825. RA Davidson I., Fromental C., Augereau P., Wildeman A., Zenke M., Chambon P. RT Cell-type specific protein binding to the enhancer of simian virus 40 in RT nuclear extracts RL Nature 323:544-548 (1986). RN [71] RX MEDLINE; 86313585. RA Sive H. L., Roeder R. G. RT Interaction of a common factor with conserved promoter and enhancer RT sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) RT genes RL Proc. Natl. Acad. Sci. USA 83:6382-6386 (1986). RN [72] RX MEDLINE; 87092300. RA Ballard D. W., Bothwell A. RT Mutational analysis of the immunoglobulin heavy chain promoter region RL Proc. Natl. Acad. Sci. USA 83:9626-9630 (1986). RN [73] RX MEDLINE; 85090419. RA Ephrussi A., Church G. M., Tonegawa S., Gilbert W. RT B Lineage-Specific Interaction of an Immunoglobulin Enhancer with Cellular RT Factors in Vivo RL Science 227:134-140 (1985). XX // AC G000538 XX ID MOUSE$IGKL XX DT 14.06.1995 (created); dbo. DT 13.01.1999 (updated); ili. CO Copyright (C), Biobase GmbH. XX SD Ig-kappa XX DE immunoglobulin kappa light chain XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.1.2 XX BS empty empty R00877; MOUSE$IGKL_01; Binding factors: NF-kappaB , BS NF-kappaB , NF-kappaB1 . BS empty empty R00895; MOUSE$IGKL_19. BS -413 -384 R03427; MOUSE$IGKL_26; Binding factors: POU2F1 . BS -379 -336 R03426; MOUSE$IGKL_25; Binding factors: POU2F1 , BS POU2F2 , POU2F2B , POU2F2 (Oct-2.1) , POU2F2 BS (Oct-2.3) , POU2F2 (Oct-2.4) , POU2F2 (Oct-2.6) , BS POU2F2 (Oct-2.1) . BS -76 -73 R00888; MOUSE$IGKL_12; Binding factors: POU2F1 . BS -76 -73 R00889; MOUSE$IGKL_13; Binding factors: NF-A3 . BS -74 -54 R00893; MOUSE$IGKL_17; Binding factors: POU2F1 . BS -74 -54 R00894; MOUSE$IGKL_18; Binding factors: POU2F2 (Oct-2.1) BS , POU2F2 , POU2F2B , POU2F2B . BS -72 -52 R00890; MOUSE$IGKL_14; Binding factors: POU2F1 . BS -72 -52 R00891; MOUSE$IGKL_15; Binding factors: POU2F1 . BS -72 -52 R00892; MOUSE$IGKL_16; Binding factors: POU2F1 , BS POU2F2 . BS 60 94 R01778; MOUSE$IGKL_20; Binding factors: POU2F1 , POU2F2 BS (Oct-2.1) . BS 100 121 R01779; MOUSE$IGKL_21; Binding factors: POU2F1 , BS POU2F2 (Oct-2.1) . BS 122 160 R01780; MOUSE$IGKL_22; Binding factors: POU2F1 , BS POU2F2 (Oct-2.1) . BS 400 424 R02981; MOUSE$IGKL_23. BS 445 469 R02982; MOUSE$IGKL_24; Binding factors: LyF-1 , PU.1 BS , NF-EM5 , PU.1 . BS 3890 3902 R00878; MOUSE$IGKL_02; Binding factors: kBF-A . BS 3938 3950 R00879; MOUSE$IGKL_03; Binding factors: KBP-1 , BS NF-kappaB1 , RelA , RelA , NF-TNF , NF-TNF BS . BS 3958 3981 R00880; MOUSE$IGKL_04; Binding factors: C/EBPgamma . BS 4006 4013 R00881; MOUSE$IGKL_05; Binding factors: E12 , E47 BS , MyoD . BS 4006 4013 R00882; MOUSE$IGKL_06; Binding factors: E12 , E47 BS , MyoD . BS 4006 4013 R00883; MOUSE$IGKL_07; Binding factors: AS-C T3 , E12 BS . BS 4006 4013 R00884; MOUSE$IGKL_08; Binding factors: AS-C T3 , E47 BS . BS 4006 4013 R00885; MOUSE$IGKL_09; Binding factors: AS-C T3 , Da BS . BS 4052 4064 R00886; MOUSE$IGKL_10; Binding factors: muEBP-C2 . BS 4057 4064 R00887; MOUSE$IGKL_11; Binding factors: NF-muE3 . XX DR EMBL: V00777; MMIG25. DR EMBL: X00268; MMIG38. DR EMBL: V01565; MMIG72. DR EMBL: V00803; MMIGK2. DR EMBL: K01641; MMIGKAAR. DR EMBL: L00089; MMIGKAF3. DR EMBL: J00569; MMIGKAQ. DR EMBL: M21794; MMIGKCX. DR EMBL: X01591; MMIGKNHR. DR EMBL: K00880; MMIGKVE. DR EMBL: M18947; MMIGKVR. DR EMBL: X00646; MMIGKVR01. DR EMBL: K02160; MMIGKVR2. DR EMBL: K02161; MMIGKVR3. DR EMBL: M18772; MMIGKWF. DR EMBL: X16954; MMVK21A. DR EMBL: X16955; MMVK21G. DR EMBL: M15554; MPIGKVNC. DR EMBL: X15878; MSIGKAPPA. DR TRANSPATH: G000538. DR SMARTDB: SM0000001. XX RN [1] RX MEDLINE; 93206099. RA Pongubala J. M. R., van Beveren C., Nagulapalli S., Klemsz M. J., McKercher RA S. R., Maki R. A., Atchison M. L. RT Effect of PU.1 phosphorylation on interaction with NF-EM5 and RT transcriptional activation RL Science 259:1622-1625 (1993). RN [2] RX MEDLINE; 92375046. RA Uchiumi F., Semba K., Yamanashi Y., Fujisawa J.-I., Yoshida M., Inoue K., RA Toyoshima K., Yamamoto T. RT Characterization of the promoter region of the src family gene lyn and its RT trans activation by human T-cell leukemia virus type I-encoded p40tax RL Mol. Cell. Biol. 12:3784-3795 (1992). RN [3] RX MEDLINE; 92107189. RA Pongubala J. M. R., Nagulapalli S., Klemsz M. J., McKercher S. R., Maki R. RA A., Atchison M. L. RT PU.1 recruits a second nuclear factor to a site important for RT immunoglobulin kappa 3' enhancer activity RL Mol. Cell. Biol. 12:368-378 (1992). RN [4] RX MEDLINE; 92318932. RA Kang S.-M., Tsang W., Doll S., Scherle P., Ko H.-S., Tran A.-C., Lenardo M. RA J., Staudt L. M. RT Induction of the POU domain transcription factor Oct-2 during T-cell RT activation by cognate antigen RL Mol. Cell. Biol. 12:3149-3154 (1992). RN [5] RX MEDLINE; 91105861. RA Sun X.-H., Baltimore D. RT An inhibitory domain of E12 transcription factor prevents DNA binding in RT E12 homodimers but not in E12 heterodimers RL Cell 64:459-470 (1991). RN [6] RX MEDLINE; 91266911. RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [7] RX MEDLINE; 91293101. RA Schreck R., Rieber P., Baeuerle P. A. RT Reactive oxygen intermediates as apparently widely used messengers in the RT activation of the NF-kappaB transcription factor and HIV-1 RL EMBO J. 10:2247-2258 (1991). RN [8] RX MEDLINE; 91331317. RA Kerr L. D., Inoue J.-I., Davis N., Link E., Baeuerle P. A., Bose jr H. R., RA Verma I. M. RT The Rel-associated pp40 protein prevents DNA binding of Rel and NF-kappaB: RT relationship with IkappaBbeta and regulation by phosphorylation RL Genes Dev. 5:1464-1476 (1991). RN [9] RX MEDLINE; 91093132. RA Zabel U., Schreck R., Baeuerle P. A. RT DNA binding of purified transcription factor NF-kappaB RL J. Biol. Chem. 266:252-260 (1991). RN [10] RX MEDLINE; 91302782. RA Jamieson C., McCaffrey P. G., Rao A., Sen R. RT Physiologic activation of T cells via the T cell receptor induces NF-kappaB RL J. Immunol. 147:416-420 (1991). RN [11] RX MEDLINE; 92017769. RA Baldwin jr A. S., Azizkhan J. C., Jensen D. E., Beg A. A., Coodly L. R. RT Induction of NF-kappaB DNA-binding activity during G0-to-G1 transition in RT mouse fibroblasts RL Mol. Cell. Biol. 11:4943-4951 (1991). RN [12] RX MEDLINE; 91117206. RA Pongubala J. M. R., Atchison M. L. RT Functional characterization of the developmentally controlled RT immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of RT helix-loop-helix transcription factors RL Mol. Cell. Biol. 11:1040-1047 (1991). RN [13] RX MEDLINE; 91172224. RA Hohmann H.-P., Kolbeck R., Remy R., van Loon A. P. G. M. RT Cyclic AMP-dependent activation of transcription factor NF-kappaB in HL60 RT cells by tumor necrosis factors alpha and beta RL Mol. Cell. Biol. 11:2315-2318 (1991). RN [14] RX MEDLINE; 92065981. RA Fan C.-M., Maniatis T. RT Generation of p50 subunit of NF-kappaB by processing of p105 through an RT ATP-dependent pathway RL Nature 354:395-398 (1991). RN [15] RX MEDLINE; 91360331. RA Hoegbom E., Magnusson A.-C., Leanderson T. RT Functional modularity in the SP6 kappa promoter RL Nucleic Acids Res. 19:4347-4354 (1991). RN [16] RX MEDLINE; 91126115. RA Meyer R., Hatada E. N., Hohmann H.-P., Haiker M., Bartsch C., RA Roethlisberger U., Lahm H.-W., Schlaeger E. J., van Loon A. P. G. M., RA Scheidereit C. RT Cloning of the DNA-binding subunit of human nuclear factor kappaB: the RT level of its mRNA is strongly regulated by phorbol ester or tumor necrosis RT factor alpha RL Proc. Natl. Acad. Sci. USA 88:966-970 (1991). RN [17] RX MEDLINE; 91173312. RA Ruben S. M., Dillon P. J., Schreck R., Henkel T., Chen C.-H., Maher M., RA Baeuerle P. A., Rosen C. A. RT Isolation of a rel-related human cDNA that potentially encodes the p65-kD RT subunit of NF-kappaB RL Science 251:1490-1493 (1991). RN [18] RX MEDLINE; 90235275. RA Zabel U., Bauerle P. A. RT Purified human IkappaB can rapidly dissociate the complex of the NF-kappaB RT transcription factor with its cognate DNA RL Cell 61:255-265 (1990). RN [19] RX MEDLINE; 90242392. RA Junker S., Pedersen S., Schreiber E., Matthias P. RT Extinction of an immunoglobulin promoter in cell hybrids is mediated by the RT octamer motif and correlates with suppression of Oct-2 expression RL Cell 61:467-474 (1990). RN [20] RX MEDLINE; 90367113. RA Ghosh S., Gifford A. M., Riviere L. R., Tempst P., Nolan G. P., Baltimore D. RT Cloning of the p50 DNA binding subunit of NF-kappaB: homology to rel and RT dorsal RL Cell 62:1019-1029 (1990). RN [21] RX MEDLINE; 90183985. RA Bergmann Y., Strich B., Sharir H., Ber R., Laskov R. RT Extinction of Ig genes expression in myeloma x fibroblast somatic cell RT hybrids is accompanied by repression of the oct-2 gene encoding a B-cell RT specific transcription factor RL EMBO J. 9:849-855 (1990). RN [22] RX MEDLINE; 91115086. RA Urban M. B., Baeuerle P. A. RT The 65-kD subunit of NF-kappaB is a receptor for IkappaB and a modulator of RT DNA-binding specificity RL Genes Dev. 4:1975-1984 (1990). RN [23] RX MEDLINE; 91115086. RA Urban M. B., Baeuerle P. A. RT The 65-kD subunit of NF-kappaB is a receptor for IkappaB and a modulator of RT DNA-binding specificity RL Genes Dev. 4:1975-1984 (1990). RN [24] RX MEDLINE; 90368700. RA Hohmann H.-P., Remy R., Poeschl B., van Loon A. P. G. M. RT Tumor necrosis factors-alpha and -beta bind to the same two types of tumor RT necrosis factor receptors and maximally activate the transcription factor RT NF-kappaB at low receptor occupancy and within minutes after receptor RT binding RL J. Biol. Chem. 265:15183-15188 (1990). RN [25] RX MEDLINE; 91093086. RA Hohmann H.-P., Brockhaus M., Baeuerle P. A., Remy R., Kolbeck R., van Loon RA A. P. G. M. RT Expression of the types A and B tumor necrosis factor (TNF) receptors is RT independently regulated, and both receptors mediate activation of the RT transcription factor NF-kappaB RL J. Biol. Chem. 265:22409-22417 (1990). RN [26] RX MEDLINE; 90205817. RA Baldwin jr A. S., LeClair K. P., Singh H., Sharp P. A. RT A large protein containing zinc finger domains binds to related sequence RT elements in the enhancers of the class I major histocompatibility complex RT and kappa immunoglobulin genes RL Mol. Cell. Biol. 10:1406-1414 (1990). RN [27] RX MEDLINE; 90220579. RA Martin D. J., van Ness B. G. RT Initiation and Processing of Two Kappa Immunoglobulin Germ Line Transcripts RT in Mouse B Cells RL Mol. Cell. Biol. 10:1950-1958 (1990). RN [28] RX MEDLINE; 90318380. RA Pessara U., Koch N. RT Tumor necrosis factor alpha regulates expression of the major RT histocompatibility complex class II-associated invariant chain by binding RT of an NF-kappaB-like factor to a promoter element RL Mol. Cell. Biol. 10:4146-4154 (1990). RN [29] RX MEDLINE; 90220875. RA Ghosh S., Baltimore D. RT Activation in vitro of NF-kappaB by phosphorylation of its inhibitor IkappaB RL Nature 344:678-682 (1990). RN [30] RX MEDLINE; 90192085. RA Nelms K., Hromas R., van Ness B. RT Identification of a second inducible DNA-protein interaction in the kappa RT immunoglobulin enhancer RL Nucleic Acids Res. 18:1037-1043 (1990). RN [31] RX MEDLINE; 91045897. RA Hazan U., Thomas D., Alcami J., Bachelerie F., Israel N., Yssel H., RA Virelizier J.-L., Arenzana-Seisdedos F. RT Stimulation of a human T-cell clone with anti-CD3 or tumor necrosis factor RT induces NF-kappaB translocation but not human immunodeficiency virus type 1 RT enhancer-dependent transcription RL Proc. Natl. Acad. Sci. USA 87:7861-7865 (1990). RN [32] RX MEDLINE; 91062349. RA Rustgi A. K., van't Veer L., Bernards R. RT Two genes encode factors with NF-kappaB- and H2TF1-like DNA-binding RT properties RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990). RN [33] RX MEDLINE; 89336785. RA Murre C., McCaw P. S., Vaessin H., Caudy M., Jan L. Y., Jan Y. N., Cabrera RA C. V., Buskin J. N., Hauschka S. D., Lassar A. B., Weintraub H., Baltimore RA D. RT Interactions between heterologous helix-loop-helix proteins generate RT complexes that bind specifically to a common DNA sequence RL Cell 58:537-544 (1989). RN [34] RX MEDLINE; 89168418. RA Murre C., McCaw P. S., Baltimore D. RT A new DNA binding and dimerization motif in immunoglobulin enhancer RT binding, daughterless, MyoD, and myc proteins RL Cell 56:777-783 (1989). RN [35] RX MEDLINE; 89195239. RA Lenardo M. J., Fan C.-M., Maniatis T., Baltimore D. RT The Involvement of NF-kB in beta-Interferon Gene Regulation Reveals Its RT Role as Widely Inducible Mediator of Signal Transduction RL Cell 57:287-294 (1989). RN [36] RX MEDLINE; 89195239. RA Lenardo M. J., Fan C.-M., Maniatis T., Baltimore D. RT The involvement of NF-kappaB in beta-interferon gene regulation reveals its RT role as a widely inducible mediator of signal transduction RL Cell 57:287-294 (1989). RN [37] RX MEDLINE; 90108665. RA Baeuerle P., Baltimore D. RT A 65-kD subunit of active NF-kappaB is required for inhibition of NF-kappaB RT by IkappaB RL Genes Dev. 3:1689-1698 (1989). RN [38] RX MEDLINE; 89219072. RA Peterson C. L., Calame K. RT Proteins Binding to Site C2 (muE3) in the Immunoglobulin Heavy-Chain RT Enhancer Exist in Multiple Oligomeric Forms RL Mol. Cell. Biol. 9:776-786 (1989). RN [39] RX MEDLINE; 89261759. RA Shirakawa F., Chedid M., Suttles J., Pollok B. A., Mizel S. B. RT Interleukin 1 and Cyclic AMP Induce k Immunoglobulin Light-Chain Expression RT vis Activation of an NF-kB-Like DNA-Binding Protein RL Mol. Cell. Biol. 9:959-964 (1989). RN [40] RX MEDLINE; 90014813. RA Mauxion F., Sen R. RT Alteration of a Single Nucleotide Allows Efficient Binding of H2TF1/KBF1 to RT the Immunoglobulin k Enhancer B Motif RL Mol. Cell. Biol. 9:3548-3552 (1989). RN [41] RX MEDLINE; 90066429. RA Currie R. A., Roeder R. G. RT Identification of an Octamer-Binding Site in the Mouse Kappa Light-Chain RT Immunoglobulin Enhancer RL Mol. Cell. Biol. 9:4239-4247 (1989). RN [42] RX MEDLINE; 89343960. RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB catalyzed by RT cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 9:2424-2430 (1989). RN [43] RX MEDLINE; 89128426. RA Clark L., Hay R. T. RT Sequence requirements for specific interaction of an enhancer binding RT protein (EBP1) with DNA RL Nucleic Acids Res. 17:499-516 (1989). RN [44] RX MEDLINE; 89315215. RA Akimenko M.-A., Ekker M., Doyen N., Biben C., Rougeon F. RT Determinant differences between the rabbit and mouse immunoglobulin kappa RT enhancers impair the activity of the rabbit enhancer in mouse myeloma cells RL Nucleic Acids Res. 17:4745-4755 (1989). RN [45] RX MEDLINE; 90098880. RA Marcuzzi A., van Ness B., Rouse T., Lafrenz D. RT Effects of anti-IgM suppression on polyclonally activated murine B cells: RT analysis of immunoglobulin mRNA, gene specific nuclear factors and cell RT cycle distribution RL Nucleic Acids Res. 17:10455-10472 (1989). RN [46] RX MEDLINE; 89242103. RA Hoyos B., Ballard D. W., Boehnlein E., Siekevitz M., Greene W. C. RT Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human RT Interleukin-2 Gene Expression RL Science 244:457-460 (1989). RN [47] RX MEDLINE; 89100307. RA Lenardo M.-J., Staudt L., Robbins P., Kuang A., Mulligan R. C., Baltimore D. RT Repression of the IgH enhancer in teratocarcinoma cells associated with a RT novel octamer factor RL Science 243:544-546 (1989). RN [48] RX MEDLINE; 88194520. RA Baeuerle P. A., Baltimore D. RT Activation of DNA-Binding Activity in an Apparently Cytoplasmic Precursor RT of the NF-kB Transcription Factor RL Cell 53:211-217 (1988). RN [49] RX MEDLINE; 89337543. RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB transcription factor RT involves dissociation of an apparently cytoplasmic NF-kappaB/inhibitor RT complex RL Cold Spring Harbor Symp. Quant. Biol. 53:789-798 (1988). RN [50] RX MEDLINE; 89030606. RA Wirth T., Baltimore D. RT Nuclear factor NF-kB can interact functionally with its cognate binding RT site to provide lymphoid-specific promoter function RL EMBO J. 7:3109-3113 (1988). RN [51] RX MEDLINE; 89096871. RA Peterson C. L., Eaton S., Calame K. RT Purified muEBP-E Binds to Immunoglobulin Enhancers and Promoters RL Mol. Cell. Biol. 8:4972-4980 (1988). RN [52] RX MEDLINE; 89070675. RA Scheidereit C., Cromlish J. A., Gerster T., Kawakami K., Balmaceda C.-G., RA Currie R. A., Roeder R. G. RT A human lymphoid-specific transcription factor that activates RT immunoglobulin genes is a homeobox protein RL Nature 336:551-557 (1988). RN [53] RX MEDLINE; 88144033. RA Hromas R., Pauli U., Marcuzzi A., Lafrenz D., Nick H., Stein J., Stein G., RA van Ness B. RT Inducible DNA-protein interactions of the murine kappa immunoglobulin RT enhancer in intact cells: comparison with in vitro interactions RL Nucleic Acids Res. 16:953-967 (1988). RN [54] RX MEDLINE; 88233974. RA Mocikat R., Pruijn G. J. M., van der Vliet P. C., Zachau H. G. RT An ACCC-containing protein-binding sequence in the neighbourhood of the RT decanucleotide recognition site of the immunoglobulin gene promoter RL Nucleic Acids Res. 16:3693 (1988). RN [55] RX MEDLINE; 89071707. RA Gaynor R. B., Kuwabara M. D., Wu F. K., Garcia J. A., Harrich D., Briskin RA M., Wall R., Sigman D. S. RT Repeated B motifs in the human immunodeficiency virus type I long terminal RT repeat enhancer region do not exhibit cooperative factor binding RL Proc. Natl. Acad. Sci. USA 85:9406-9410 (1988). RN [56] RX MEDLINE; 88263016. RA Kawakami K., Scheidereit C., Roeder R. G. RT Identification and purification of a human immunoglobulin-enhancer-binding RT protein (NF-kappaB) that activates transcription from a human RT immunodeficiency virus type 1 promoter in vitro RL Proc. Natl. Acad. Sci. USA 85:4700-4704 (1988). RN [57] RX MEDLINE; 89058614. RA Briskin M., Kuwabara M. D., Sigman D. S., Wall R. RT Induction of kappa transcription by interferon-gamma without activation of RT NF-kappaB RL Science 242:1036-1037 (1988). RN [58] RX MEDLINE; 89019389. RA Baeuerle P., Baltimore D. RT IkappaB: A specific inhibitor of the NF-kappaB transcription factor RL Science 242:540-546 (1988). RN [59] RX MEDLINE; 88290676. RA Staudt L. M., Clerc R. G., Singh H., LeBowitz J. H., Sharp P. A., Baltimore RA D. RT Cloning of a lymphoid-specific cDNA encoding a protein binding the RT regulatory octamer DNA motif RL Science 241:577-580 (1988). RN [60] RX MEDLINE; 87078388. RA Atchison M. L., Perry R. P. RT The Role of the kappa Enhancer and Its Binding Factor NF-kB in the RT Developmental Regulation of kappa Gene Transcription RL Cell 48:121-128 (1987). RN [61] RX MEDLINE; 88052881. RA Scheidereit C., Heguy A., Roeder R. G. RT Identification and Purification of a Human Lymphoid-Specific RT Octamer-Binding Protein (OTF-2) That Activates Transcription of an RT Immunoglobulin Promoter In Vitro RL Cell 51:783-793 (1987). RN [62] RX MEDLINE; 88111566. RA Pruijn G. J. M., van Driel W., van Miltenburg R. T., van der Vliet P. C. RT Promoter and enhancer elements containing a conserved sequence motif are RT recognized by nuclear factor III, a protein stimulating adenovirus DNA RT replication RL EMBO J. 6:3771-3778 (1987). RN [63] RX MEDLINE; 86298399. RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). RN [64] RX MEDLINE; 86092241. RA Singh H., Sen R., Baltimore D., Sharp P. A. RT A nuclear factor that binds to a conserved sequence motif in RT transcriptional control elements of immunoglobulin genes RL Nature 319:154-158 (1986). RN [65] RX MEDLINE; 87039335. RA Staudt L. M., Singh H., Sen R., Wirth T., Sharp P. A., Baltimore D. RT A lymphoid-specific protein binding to the octamer motif of immunoglobulin RT genes RL Nature 323:640-643 (1986). RN [66] RX MEDLINE; 86313585. RA Sive H. L., Roeder R. G. RT Interaction of a common factor with conserved promoter and enhancer RT sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) RT genes RL Proc. Natl. Acad. Sci. USA 83:6382-6386 (1986). XX // AC G000539 XX ID MOUSE$IGKLE XX DT 21.05.1996 (created); ake. DT 21.05.1996 (updated); ake. CO Copyright (C), Biobase GmbH. XX SD IGKL XX DE immunoglobulin kappa light-chain enhancer XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.1.2 XX DR TRANSCOMPEL: C00030. XX // AC G000540 XX ID MOUSE$IGL24E XX DT 21.05.1996 (created); ake. DT 21.05.1996 (updated); ake. CO Copyright (C), Biobase GmbH. XX SD IGL XX DE Immunoglobulin lambda 2-4 enhancer XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.1.3 XX DR TRANSCOMPEL: C00024. XX // AC G000541 XX ID MOUSE$IGLL XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Ig-lambda XX DE immunoglobulin lambda light chain XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.1.3 XX BS -140 -132 R03509; MOUSE$IGLL_02; Binding factors: LyF-1 . BS -119 -108 R03511; MOUSE$IGLL_04. BS -109 -90 R02380; MOUSE$IGLL_01; Binding factors: NF-lambda2 . BS -96 -88 R03512; MOUSE$IGLL_05; Binding factors: LyF-1 . BS -83 -75 R03510; MOUSE$IGLL_03; Binding factors: LyF-1 . BS -71 -63 R03513; MOUSE$IGLL_06; Binding factors: LyF-1 . BS -48 -39 R03514; MOUSE$IGLL_07. BS -29 -16 R03515; MOUSE$IGLL_08. BS -15 -1 R03516; MOUSE$IGLL_09. BS 25 31 R03517; MOUSE$IGLL_10. BS 15500 0 R04262; MOUSE$IGLL_11. BS 15500 0 R04263; MOUSE$IGLL_12. BS 15500 0 R04264; MOUSE$IGLL_13. BS 35000 0 R04265; MOUSE$IGLL_14. BS 35000 0 R04266; MOUSE$IGLL_15. BS 35000 0 R04267; MOUSE$IGLL_16. XX DR EMBL: X54550; MMELAM24. DR EMBL: X54608; MMELAM31. DR EMBL: X05557; MMVPREB2. DR EMBL: X05563; MMVPREB3. DR TRANSPATH: G000541. DR TRRD: 00037. XX RN [1] RX MEDLINE; 92107183. RA Rudin C. M., Storb U. RT Two conserved essential motifs of the murine immunoglobulin lambda RT enhancers bind B-cell-specific factors RL Mol. Cell. Biol. 12:309-320 (1992). RN [2] RX MEDLINE; 92017799. RA Lo K., Landau N. R., Smale S. T. RT LyF-1, a transcriptional regulator that interacts with a novel class of RT promoters for lymphocytes-specific genes RL Mol. Cell. Biol. 11:5229-5243 (1991). RN [3] RX MEDLINE; 91042519. RA Chang L. A., Murialdo H. RT Interaction of a nuclear protein with a palindromic sequence of the mouse RT immunoglobulin lambda2-chain gene promoter is important for its RT transcription RL Mol. Cell. Biol. 10:5894-5902 (1990). XX // AC G000542 XX ID MOUSE$IGF2 XX DT 21.05.1996 (created); ake. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD IGF-II XX DE insulin-like growth factor II XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.5 XX DR TRRD: 00156. XX // AC G000543 XX ID MOUSE$ICSBP XX DT 21.05.1996 (created); ake. DT 21.05.1996 (updated); ake. CO Copyright (C), Biobase GmbH. XX SD ICSBP XX DE interferon consensus sequence binding protein XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.2.4 XX DR TRRD: 00219. XX // AC G000545 XX ID MOUSE$JUND XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD junD XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.1.6 XX BS -197 -190 R03381; MOUSE$JUND_01. BS -108 -101 R03382; MOUSE$JUND_02; Binding factors: Sp1 . BS -97 -90 R03383; MOUSE$JUND_03; Binding factors: POU2F1 . BS -75 -70 R03384; MOUSE$JUND_04. BS -63 -55 R03385; MOUSE$JUND_05; Binding factors: Sp1 . BS -53 -46 R03386; MOUSE$JUND_06; Binding factors: AP-1 , c-Fos BS , c-Jun . BS -43 -35 R03387; MOUSE$JUND_07. BS -29 -23 R03388; MOUSE$JUND_08. BS -18 -10 R03389; MOUSE$JUND_09; Binding factors: Sp1 . XX DR EMBL: J04509; MMJUND. DR TRANSPATH: G000545. XX RN [1] RX MEDLINE; 91330875. RA de Groot R. P., Karperien M., Pals C., Kruijer W. RT Characterization of the mouse junD promoter - high basal level activity due RT to an octamer motif RL EMBO J. 10:2523-2532 (1991). XX // AC G000546 XX ID MOUSE$IGK3E XX DT 21.05.1996 (created); ake. DT 21.05.1996 (updated); ake. CO Copyright (C), Biobase GmbH. XX SD kE3' XX DE Immunoglobulin kappa 3'enhancer XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.1.2 XX DR TRANSCOMPEL: C00025. DR TRANSCOMPEL: C00247. DR TRANSCOMPEL: C00248. XX // AC G000547 XX ID MOUSE$KROX XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Krox-20 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.2.4 XX BS 228 249 R00961; MOUSE$KROX_01; Binding factors: Elk-1 , SAP-1a BS , SRF , SAP-1b . XX DR EMBL: M24376; MMKROX1. DR TRANSPATH: G000547. DR TRRD: 00233. XX RN [1] RX MEDLINE; 93049215. RA Treisman R., Marais R., Wynne J. RT Spatial flexibility in ternary complexes between SRF and its accessory RT proteins RL EMBO J. 11:4631-4640 (1992). RN [2] RX MEDLINE; 89219073. RA Chavrier P., Janssen-Timmen U., Mattei M.-G., Zerial M., Bravo R., Charnay RA P. RT Structure, Chromosome Location and Expression of the Mouse Zinc Finger Gene RT Krox-20: Multiple Gene Products and Coregulation with the Proto-Oncogene RT c-fos RL Mol. Cell. Biol. 9:787-797 (1989). XX // AC G000548 XX ID MOUSE$LDHA XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD LDH-A XX DE lactate dehydrogenase A subunit XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4 XX BS -93 -73 R10597; MOUSE$LDHA_02; Binding factors: HIF-1 . BS -75 -50 R10599; MOUSE$LDHA_03; Binding factors: HIF-1 . BS -55 -32 R00963; MOUSE$LDHA_01; Binding factors: CREB , CREB BS , deltaCREB , 47-kDa CRE bind. prot. , ATF-1 BS . XX DR EMBL: X03753; MMALDH1. DR EMBL: Y00309; MMLDHAG. DR TRANSPATH: G000548. DR BRENDA: 1.1.1.27; Mouse. XX RN [1] RX MEDLINE; 98298253. RA Ebert B. L., Bunn H. F. RT Regulation of transcription by hypoxia requires a multiprotein complex that RT includes hypoxia-inducible factor 1, an adjacent transcription factor, and RT p300/CREB binding protein. RL Mol. Cell. Biol. 18:4089-4096 (1998). RN [2] RX MEDLINE; 97115775. RA Semenza G. L., Jiang B. H., Leung S. W., Passantino R., Concordet J. P., RA Maire P., Giallongo A. RT Hypoxia response elements in the aldolase A, enolase 1, and lactate RT dehydrogenase A gene promoters contain essential binding sites for RT hypoxia-inducible factor 1. RL J. Biol. Chem. 271:32529-32537 (1996). RN [3] RX MEDLINE; 89214111. RA Kwast-Welfeld J., Soong C.-J., Short M. L., Jungmann R. A. RT Identification of Rat Ovarian Nuclear Factors That Interact with the RT cAMP-inducible Lactate Dehydrogenase A Subunit Promoter RL J. Biol. Chem. 264:6941-6947 (1989). XX // AC G000549 XX ID MOUSE$LFER XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD LFER XX DE lactoferrin XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3 XX BS -351 -322 R03563; MOUSE$LFER_01; Binding factors: ER-alpha , BS COUP-TF . XX DR EMBL: M74778; MMLFP. DR TRANSPATH: G000549. DR TRANSCOMPEL: C00019. XX RN [1] RX MEDLINE; 92261589. RA Liu Y., Teng C. T. RT Estrogen response module of the mouse lactoferrin gene contains overlapping RT chicken ovalbumin up-stream promoter transcription factor and estrogen RT receptor-binding elements RL Mol. Endocrinol. 6:355-364 (1992). XX // AC G000550 XX ID MOUSE$LB1 XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD LB1 XX DE laminin B1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -477 -432 R03928; MOUSE$LB1_01; Binding factors: RAR-alpha1 , BS RAR-gamma , RAR-beta , RAR-gamma . XX DR TRANSPATH: G000550. DR TRRD: 00041. XX RN [1] RX MEDLINE; 93066223. RA Ross T. K., Prahl J. M., Herzberg I. M., DeLuca H. F. RT Baculovirus-mediated expression of retinoic acid receptor type gamma in RT cultured insect cells reveals a difference in specific DNA-binding behavior RT with the 1,25-dihydroxyvitamin D3 receptor RL Proc. Natl. Acad. Sci. USA 89:10282-10286 (1992). RN [2] RX MEDLINE; 91216109. RA Vasios G., Mader S., Gold J. D., Leid M., Lutz Y., Gaub M.-P., Chambon P., RA Gudas L. RT The late retinoic acid induction of laminin B1 gene transcription involves RT RAR binding to the responsive element RL EMBO J. 10:1149-1158 (1991). XX // AC G000551 XX ID MOUSE$LY6E XX DT 14.06.1995 (created); dbo. DT 16.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Ly-6E XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5 XX BS -136 -106 R02404; MOUSE$LY6E_01. BS -113 -88 R02405; MOUSE$LY6E_02. XX DR EMBL: M37707; MMLY6EA. DR TRRD: 00283. XX RN [1] RX MEDLINE; 90377204. RA Khan K. D., Lindwall G., Maher St. E., Bothwell A. L. M. RT Characterization of promoter elements of an interferon-inducible Ly-6E/A RT differentiation antigen, which is expressed on activated T cells and RT hematopoietic stem cells RL Mol. Cell. Biol. 10:5150-5159 (1990). XX // AC G000552 XX ID MOUSE$M2ABD XX DT 21.05.1996 (created); ake. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Abeta d XX DE MHC class II Abeta d gene, IAbeta d XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.2 XX DR TRRD: 00225. XX // AC G000553 XX ID MOUSE$M2EBD XX DT 21.05.1996 (created); ake. DT 19.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Ebeta d XX DE MHC class II IEbeta d gene, IEbeta d XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.2 XX DR TRRD: 00227. XX // AC G000554 XX ID MOUSE$MB1 XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD mb-1 XX DE membrane immunoglobulin-associated protein XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -181 -160 R03699; MOUSE$MB1_02; Binding factors: COE1 , BLyF BS . BS -66 -23 R03475; MOUSE$MB1_01; Binding factors: c-Ets-1 , PU.1 BS , Sp1 , MUF1 , MUF2 , GADD 153 , BS v-Ets , PU.1 , NERF-1a . XX DR EMBL: M31773; MMMB101. DR TRANSPATH: G000554. DR TRANSCOMPEL: C00239. DR TRRD: 00241. XX RN [1] RX MEDLINE; 96347578. RA Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T. A. RT Characterization of NERF, a novel transcription factor related to the Ets RT factor ELF-1 RL Mol. Cell. Biol. 16:5091-5106 (1996). RN [2] RX MEDLINE; 93028372. RA Hagman J., Grosschedl R. RT An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates RT differential binding of Ets family factors to promoter sequences of the RT mb-1 gene RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992). RN [3] RX MEDLINE; 92186844. RA Feldhaus A. L., Mbangkollo D., Arvin K. L., Klug C. A., Singh H. RT BLyf, a novel cell-type- and stage-specific regulator of the B-lymphocyte RT gene mb-1 RL Mol. Cell. Biol. 12:1126-1133 (1992). RN [4] RX MEDLINE; 92007792. RA Hagman J., Travis A., Grosschedl R. RT A novel lineage-specific nuclear factor regulates mb-1 gene transcription RT at the early stages of B cell differentiation RL EMBO J. 10:3409-3417 (1991). RN [5] RX MEDLINE; 92017857. RA Travis A., Hagman J., Grosschedl R. RT Heterogeneously initiated transcription from the pre-B- and B-cell-specific RT mb-1 promoter: analysis of the requirement for upstream factor-binding RT sites and initiation site sequences RL Mol. Cell. Biol. 11:5756-5766 (1991). XX // AC G000555 XX ID MOUSE$MBP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MBP XX DE myelin basic protein XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.11 XX BS -186 -163 R03886; MOUSE$MBP_06; Binding factors: T3R-alpha , BS T3R-beta , T3R-beta1 , T3R-beta2 . BS -130 -111 R01162; MOUSE$MBP_01; Binding factors: NF-1 , NF-1 BS , NF-1B1 . BS -110 -97 R01163; MOUSE$MBP_02; Binding factors: M1 , M1 BS . BS -92 -81 R01164; MOUSE$MBP_03; Binding factors: Sp1 , Sp1 BS . BS -73 0 R02750; MOUSE$MBP_05; Binding factors: TFIID . BS -30 0 R02749; MOUSE$MBP_04; Binding factors: TFIID . XX DR EMBL: M24410; MMMBPA. DR TRANSPATH: G000555. XX RN [1] RX MEDLINE; 95296359. RA Tomura H., Lazar J., Phyllaier M., Nikodem V. M. RT The N-terminal region (A/B) of rat thyroid hormone receptors alpha1, beta1 RT but not beta2 contains a strong thyroid hormone-dependent transactivation RT function RL Proc. Natl. Acad. Sci. USA 92:5600-5604 (1995). RN [2] RX MEDLINE; 92348442. RA Farsetti A., Desvergne B., Hallenbbeck P., Robbins J., Nikodem V. M. RT Caracterization of myelin basic protein Thyroid hormone response element RT and its function in the context of native and heterologous prommoter RL J. Biol. Chem. 267:15784-15788 (1992). RN [3] RA Miura M., Tamura T.-A., Mikoshiba K. RT Involvement of the nuclear factor I motif in the mouse myelin protein RT promoter in cell-specific regulation: comparison with the mouse glial RT fibrillary acidic protein promoter RL Develop. Growth & Differ. 33:111-116 (1991). RN [4] RX MEDLINE; 92078194. RA Farsetti A., Mitsuhashi T., Desvergne B., Robbins J., Nikodem V. M. RT Molecular basis of thyroid hormone regulation of myelin basic protein gene RT expression in rodent brain RL J. Biol. Chem. 266:23226-23232 (1991). RN [5] RX MEDLINE; 90211242. RA Aoyama A., Tamura T.-A., Mikoshiba K. RT Regulation of brain-specific transcription of the mouse myelin basic RT protein gene: function of the NFI-binding site in the distal promoter RL Biochem. Biophys. Res. Commun. 167:648-653 (1990). RN [6] RX MEDLINE; 91006002. RA Tamura T.-A., Sumita K., Hirose S., Mikoshiba K. RT Core promoter of the mouse myelin basic protein gene governs brain-specific RT transcription in vitro RL EMBO J. 9:3101-3108 (1990). RN [7] RX MEDLINE; 91035434. RA Inoue T., Tamura T.-A., Furuichi T., Mikoshiba K. RT Isolation of complementary DNAs encoding a cerebellum-enriched nuclear RT factor I family that activates transcription from the mouse myelin basic RT protein promoter RL J. Biol. Chem. 265:19065-19070 (1990). XX // AC G000556 XX ID MOUSE$MCCPA XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD MC-CPA XX DE mast cell carboxypeptidase A XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4 XX BS -62 -27 R03884; MOUSE$MCCPA_01; Binding factors: GATA-1 , BS GATA-2 . XX DR TRANSPATH: G000556. DR BRENDA: 3.4.17.1; Mouse. XX RN [1] RX MEDLINE; 92078154. RA Zon L. I., Gurish M. F., Stevens R. L., Mather C., Reynolds D. S., Austen RA K. F., Orkin S. H. RT GATA-binding transcription factors in mast cells regulate the promoter of RT the mast cell carboxypeptidase A gene RL J. Biol. Chem. 266:22948-22953 (1991). XX // AC G000557 XX ID MOUSE$MCK XX DT 14.06.1995 (created); dbo. DT 30.10.2001 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD mck XX DE muscle-type creatine kinase XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.4.10 XX BS empty empty R00245; MOUSE$MCK_06; Binding factors: MEF1 . BS empty empty R09455; MOUSE$MCK_09. BS empty empty R09465; MOUSE$MCK_10; Binding factors: MEF-2 . BS -3182 -3133 R11384; MOUSE$MCK_11; Binding factors: p53 , p53 BS . BS -1256 -1050 R00240; MOUSE$MCK_01; Binding factors: E12 , MEF1 BS , MyoD , TFE3-S , SUM-1 . BS -1256 -1050 R00241; MOUSE$MCK_02; Binding factors: E12 , E47 BS , MF3 , MyoD . BS -1200 -1173 R03585; MOUSE$MCK_07; Binding factors: MEF-2 , MEF-2 BS , aMEF-2 , MEF-2 (516 AA) . BS -1170 0 R04428; MOUSE$MCK_08. BS -1156 -1135 R00242; MOUSE$MCK_03; Binding factors: E12 , E47 BS , ITF-2 , MASH-1 , MASH-2 , MEF1 , BS MRF4 , MyoD , myogenin , MyoD , HEB BS , MASH-1 , MASH-1 , ASH-1 , ASH-3a BS , ASH-3b . BS -1094 -1048 R00243; MOUSE$MCK_04; Binding factors: MBF-1 . BS -1091 -1062 R00244; MOUSE$MCK_05; Binding factors: MEF-2 , MEF-2 BS , MEF-2 , aMEF-2 , MEF-2 (516 AA) . XX DR EMBL: AF188002; AF188002. DR EMBL: M21390; MMMCKA. DR TRANSPATH: G000557. DR TRANSCOMPEL: C00029. DR TRANSCOMPEL: C00034. DR BRENDA: 2.7.3.2; Mouse. DR TRRD: 00312. XX RN [1] RX MEDLINE; 91271234. RA Weintraub H., Hauschka S., Tapscott S. J. RT The MCK enhancer contains a p53 responsive element. RL Proc. Natl. Acad. Sci. USA 88:4570-4571 (1991). RN [2] RX MEDLINE; 98370371. RA Grayson J., Bassel-Duby R., Williams R. S. RT Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene RT regulation RL J. Cell. Biochem. 70:366-375 (1998). RN [3] RX MEDLINE; 98352826. RA Tamir Y., Bengal E. RT p53 protein is activated during muscle differentiation and participates RT with MyoD in the transcription of muscle creatine kinase gene. RL Oncogene 17:347-356 (1998). RN [4] RX MEDLINE; 97163415. RA Bourdon J. C., Deguin-Chambon V., Lelong J. C., Dessen P., May P., Debuire RA B., May E. RT Further characterisation of the p53 responsive element--identification of RT new candidate genes for trans-activation by p53. RL Oncogene 14:85-94 (1997). RN [5] RX MEDLINE; 96394665. RA Ornatsky O.I., McDermott J.C. RT MEF2 protein expression, DNA binding specificity and complex composition, RT and transcriptional activity in muscle and non-muscle cells RL J. Biol. Chem. 271:24927-24933 (1996). RN [6] RX MEDLINE; 95403385. RA Apone S., Hauschka S. D. RT Muscle gene E-box control elements RL J. Biol. Chem. 270:21420-21427 (1995). RN [7] RX MEDLINE; 96069901. RA Olson E.N., Perry M., Schulz R.A. RT Regulation of muscle differentiation by the MEF2 family of MADS box RT transcription factors RL Dev. Biol. 172:2-14 (1995). RN [8] RX MEDLINE; 95063991. RA Kaushal S., Schneider J. W., Nadal-Ginard B., Mahdavi V. RT Activation of the myogenic lineage by MEF2A, a factor that induces and RT cooperates with MyoD RL Science 266:1236-1240 (1994). RN [9] RX MEDLINE; 94043282. RA Mitsui K., Shirakata M., Paterson B. M. RT Phosphorylation inhibits the DNA-binding activity of MyoD homodimers but RT not MyoD-E12 heterodimers RL J. Biol. Chem. 268:24415-24420 (1993). RN [10] RX MEDLINE; 92387551. RA Yu Y.-T., Breitbart R. E., Smoot L. B., Lee Y., Mahdavi V., Nadal-Ginard B. RT Human myocyte-specific enhancer factor 2 comprises a group of RT tissue-restricted MADS box transcription factors RL Genes Dev. 6:1783-1798 (1992). RN [11] RX MEDLINE; 92228833. RA Johnson J. E., Birren S. J., Saito T., Anderson D. J. RT DNA binding and transcriptional regulatory activity of mammalian RT achaete-scute homologous (MASH) proteins revealed by interaction with a RT muscle-specific enhancer RL Proc. Natl. Acad. Sci. USA 89:3596-3600 (1992). RN [12] RX MEDLINE; 92188160. RA Anthony-Cahill S. J., Benfield P. A., Fairman R., Wasserman Z. R., Brenner RA S. L., Stafford III W. F., Altenbach C., Hubbell W. L., DeGrado W. F. RT Molecular characterization of helix-loop-helix peptides RL Science 255:979-983 (1992). RN [13] RX MEDLINE; 93024452. RA Shaknovich R., Shue G., Kohtz D. S. RT Conformational activation of a basic helix-loop-helix protein (MyoD1) by RT the C-terminal region of murine HSP90 (HSP84) RL Mol. Cell. Biol. 12:5059-5068 (1992). RN [14] RX MEDLINE; 93024459. RA Johnston L. A., Tapscott S. J., Eisen H. RT Sodium butyrate inhibits myogenesis by interfering with the transcriptional RT activation function of MyoD and myogenin RL Mol. Cell. Biol. 12:5123-5130 (1992). RN [15] RX MEDLINE; 92123207. RA Roman C., Matera A. G., Cooper C., Artandi S., Blain S., Ward D. C., Calame RA K. RT mTFE3, an X-linked transcriptional activator containing basic RT helix-loop-helix and zipper domains, utilizes the zipper to stabilize both RT DNA binding and multimerization RL Mol. Cell. Biol. 12:817-827 (1992). RN [16] RX MEDLINE; 92186835. RA Hu J.-S., Olson E. N., Kingston R. E. RT HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate RT the DNA-binding ability of myogenic regulatory factors RL Mol. Cell. Biol. 12:1031-1042 (1992). RN [17] RX MEDLINE; 91309143. RA Lassar A. B., Davis R. L., Wright W. E., Kadesch T., Murre C., Voronova A., RA Baltimore D., Weintraub H. RT Functional activity of myogenic HLH proteins requires RT hetero-oligomerization with E12/E47-like proteins in vivo RL Cell 66:305-315 (1991). RN [18] RX MEDLINE; 91131581. RA Chakraborty T., Brennan T., Olson E. RT Differential trans-activation of a muscle-specific enhancer by myogenic RT helix-loop-helix proteins is separable from DNA binding RL J. Biol. Chem. 266:2878-2882 (1991). RN [19] RX MEDLINE; 91117219. RA Murre C., Voronova A., Baltimore D. RT B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like RT subunits RL Mol. Cell. Biol. 11:1156-1160 (1991). RN [20] RX MEDLINE; 92017759. RA Cserjesi P., Olson E. N. RT Myogenin induces the myocyte-specific enhancer binding factor MEF-2 RT independently of other muscle-specific gene products RL Mol. Cell. Biol. 11:4854-4862 (1991). RN [21] RX MEDLINE; 91172180. RA Santoro I. M., Yi T.-M., Walsh K. RT Identification of single-stranded-DNA-binding proteins that interact with RT muscle gene elements RL Mol. Cell. Biol. 11:1944-1953 (1991). RN [22] RX MEDLINE; 91260712. RA Chakraborty T., Brennan T. J., Li L., Edmondson D., Olson E. N. RT Inefficient homooligomerization contributes to the dependence of myogenin RT on E2A products for efficient DNA binding RL Mol. Cell. Biol. 11:3633-3641 (1991). RN [23] RX MEDLINE; 91288527. RA Brennan T. J., Chakraborty T., Olson E. N. RT Mutagenesis of the myogenin basic region identifies an ancient protein RT motif critical for activation of myogenesis RL Proc. Natl. Acad. Sci. USA 88:5675-5679 (1991). RN [24] RX MEDLINE; 91296792. RA Venuti J. M., Goldberg L., Chakraborty T., Olson E. N., Klein W. H. RT A myogenic factor from sea urchin embryos capable of programming muscle RT differentiation in mammalian cells RL Proc. Natl. Acad. Sci. USA 88:6219-6223 (1991). RN [25] RX MEDLINE; 90182663. RA Davis R. L., Cheng P.-F., Lassar A. B., Weintraub H. RT The MyoD DNA binding domain contains a recognition code for muscle-specific RT gene activation RL Cell 60:733-746 (1990). RN [26] RX MEDLINE; 90199896. RA Benezra R., Davis R. L., Lockshon D., Turner D. L., Weintraub H. RT The protein Id: a negative regulator of helix-loop-helix DNA binding RT proteins RL Cell 61:49-59 (1990). RN [27] RX MEDLINE; 90299130. RA Brennan T. J., Olson E. N. RT Myogenin resides in the nucleus and acquires high affinity for a conserved RT enhancer element on heterodimerization RL Genes Dev. 4:582-595 (1990). RN [28] RX MEDLINE; 90332633. RA Weintraub H., Davis R., Lockshon D., Lassar A. RT MyoD binds cooperatively to two sites in a target enhancer sequence: RT Occupancy of two sites is required for activation RL Proc. Natl. Acad. Sci. USA 87:5623-5627 (1990). RN [29] RX MEDLINE; 89376533. RA Lassar A. B., Buskin J. B., Lockshon D., Davis R. L., Apone S., Hauschka S. RA D., Weintraub H. RT MyoD is a sequence-specific DNA-binding protein requiring a region of myc RT homology to bind to the muscle creatine kinase enhancer RL Cell 58:823-831 (1989). RN [30] RX MEDLINE; 89336785. RA Murre C., McCaw P. S., Vaessin H., Caudy M., Jan L. Y., Jan Y. N., Cabrera RA C. V., Buskin J. N., Hauschka S. D., Lassar A. B., Weintraub H., Baltimore RA D. RT Interactions between heterologous helix-loop-helix proteins generate RT complexes that bind specifically to a common DNA sequence RL Cell 58:537-544 (1989). RN [31] RX MEDLINE; 89343980. RA Buskin J. N., Hauschka S. D. RT Identification of a Myocyte Nuclear Factor That Binds to the RT Muscle-Specific Enhancer of the Mouse Muscle Creatine Kinase Gene RL Mol. Cell. Biol. 9:2627-2640 (1989). RN [32] RX MEDLINE; 90097919. RA Gossett L. A., Kelvin D. J., Sternberg E. A., Olson E. N. RT A new myocyte-specific enhancer-binding factor that recognizes a conserved RT element associated with multiple muscle-specific genes RL Mol. Cell. Biol. 9:5022-5033 (1989). XX // AC G000558 XX ID MOUSE$COX5 XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD MCO5B XX DE cytochrome c oxidase subunit Vb XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.11 XX BS -59 -39 R04066; MOUSE$COX5_01. BS -22 -1 R04067; MOUSE$COX5_02. BS 13 33 R04068; MOUSE$COX5_03. XX DR BRENDA: 1.9.3.1. XX RN [1] RX MEDLINE; 93194058. RA Virbasius J. V., Virbasius C.-M. A., Scarpulla R. C. RT Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase RT expression, reveals a cellular role for an Ets domain activator of viral RT promoters RL Genes Dev. 7:380-392 (1993). XX // AC G000559 XX ID MOUSE$MT1 XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MT-I XX DE metallothionein I XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.1 XX BS -175 -161 R03449; MOUSE$MT1_05; Binding factors: MTF-1 . BS -153 -127 R01021; MOUSE$MT1_01; Binding factors: Sp1 . BS -148 -136 R01022; MOUSE$MT1_02; Binding factors: MBF-I , MTF-1 BS , Sp1 , Sp1 . BS -132 -118 R03450; MOUSE$MT1_06; Binding factors: MTF-1 . BS -70 -56 R08297; MOUSE$MT1_07; Binding factors: MTF-1 . BS -54 -40 R02016; MOUSE$MT1_03; Binding factors: MTF-1 , ZAP BS . BS -36 -17 R03173; MOUSE$MT1_04; Binding factors: TBP . XX DR EMBL: X15128; MMMETAL1. DR TRANSPATH: G000559. DR TRRD: 00080. XX RN [1] RX MEDLINE; 96421625. RA Dalton T. P., Li Q., Bittel D., Liang L., Andrews G. K. RT Oxidative stress activates metal-responsive transcription factor-1 binding RT activity. Occupancy in vivo of metal response elements in the RT metallothionein-I gene promoter. RL J. Biol. Chem. 271:26233-26241 (1996). RN [2] RX MEDLINE; 94298778. RA Heuchel R., Radtke F., Georgiev O., Stark G., Aguet M., Schaffner W. RT The transcription factor MTF-1 is essential for basal and heavy RT metal-induced metallothionein gene expression RL EMBO J. 13:2870-2875 (1994). RN [3] RX MEDLINE; 93223676. RA Radtke F., Heuchel R., Georgiev O., Hergersberg M., Gariglio M., Dembic Z., RA Schaffner W. RT Cloned transcription factor MTF-1 activates the mouse metallothionein I RT promoter RL EMBO J. 12:1355-1362 (1993). RN [4] RX MEDLINE; 91334134. RA Labbe S., Prevost J., Remondelli P., Leone A., Seguin C. RT A nuclear factor binds to the metal regulatory elements of the mouse gene RT encoding metallothionein-I RL Nucleic Acids Res. 19:4225-4231 (1991). RN [5] RX MEDLINE; 91153662. RA Seguin C. RT A nuclear factor requires Zn2+ to bind a regulatory MRE element of the RT mouse gene encoding metallothionein-1. RL Gene 97:295-300 (1991). RN [6] RX MEDLINE; 90370445. RA Searle P. F. RT Zinc dependent binding of a liver nuclear factor to metal response element RT MRE-a of the mouse metallothionein-I gene and variant sequences RL Nucleic Acids Res. 18:4683-4690 (1990). RN [7] RX MEDLINE; 91067668. RA Kambadur R., Culotta V., Hamer D. RT Cloned yeast and mammalian transcription factor TFIID gene products support RT basal but not activated metallothionein gene transcription RL Proc. Natl. Acad. Sci. USA 87:9168-9142 (1990). RN [8] RX MEDLINE; 90066481. RA Imbert J., Zafarullah M., Culotta V. C., Gedamu L., Hamer D. RT Transcription Factor MBF-I Interacts with Metal Regulatory Elements of RT Higher Eukaryotic Metallothionein Genes RL Mol. Cell. Biol. 9:5315-5323 (1989). RN [9] RX MEDLINE; 89091123. RA Westin G., Schaffner W. RT A zinc-responsive factor interacts with a metal-regulated enhancer element RT (MRE) of the mouse metallothionein-I gene RL EMBO J. 7:3763-3770 (1988). RN [10] RX MEDLINE; 87149062. RA Seguin C., Hamer D. H. RT Regulation in Vitro of Metallothionein Gene Binding Factors RL Science 235:1383-1387 (1987). RN [11] RX MEDLINE; 85295983. RA Searle P. F., Stuart G. W., Palmiter R. D. RT Building a metal-responsive promoter with synthetic regulatory elements. RL Mol. Cell. Biol. 5:1480-1489 (1985). RN [12] RX MEDLINE; 86040453. RA Stuart G. W., Searle P. F., Palmiter R. D. RT Identification of multiple metal regulatory elements in mouse RT metallothionein-I promoter by assaying synthetic sequences. RL Nature 317:828-831 (1985). XX // AC G000560 XX ID MOUSE$M1H2DD XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H-2Dd XX DE MHC class I H-2Dd XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.1 XX BS -205 -188 R01050; MOUSE$M1H2DD_01; Binding factors: AP-1 . BS -157 -140 R01051; MOUSE$M1H2DD_02; Binding factors: ICSBP , BS IRF1 , IRF-2 . BS -108 -90 R01052; MOUSE$M1H2DD_03; Binding factors: AP-1 . XX DR EMBL: M16444; MMMH2DDP. DR EMBL: M27034; MMMHD2D. DR TRANSPATH: G000560. DR TRRD: 00234. XX RN [1] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [2] RX MEDLINE; 89354547. RA Harada H., Fujita T., Miyamoto M., Kimura Y., Maruyama M., Furia A., Miyata RA T., Taniguchi T. RT Structurally similar but functionally distinct factors, IRF-1 and IRF-2, RT bind to the same regulatory elements of IFN and IFN-inducible genes RL Cell 58:729-739 (1989). RN [3] RX MEDLINE; 88145688. RA Korber B., Mermod N., Hood L., Stroynowski I. RT Regulation of Gene Expression by Interferons: Control of H-2 Promoter RT Responses RL Science 239:1302-1306 (1988). XX // AC G000561 XX ID MOUSE$M1H2KB XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H-2Kb XX DE MHC class I H-2Kb XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.1 XX BS -1810 -1733 R02602; MOUSE$M1H2KB_11. BS -210 -181 R01053; MOUSE$M1H2KB_01; Binding factors: ATF , CREB BS , RXR-beta . BS -197 -158 R01054; MOUSE$M1H2KB_02; Binding factors: AP-2alpha , BS AP-2alphaA , AP-2alphaB . BS -188 -160 R01055; MOUSE$M1H2KB_03; Binding factors: AP-2alphaA BS , AP-2alphaB . BS -187 -176 R01056; MOUSE$M1H2KB_04; Binding factors: NF-kappaB . BS -175 -152 R01057; MOUSE$M1H2KB_05; Binding factors: NF-kappaB1 BS , MBP-2 , NF-kappaB1 , NF-TNF , AT-BP1 BS , AT-BP2 , NF-kappaB1 . BS -171 -158 R01058; MOUSE$M1H2KB_06; Binding factors: c-Rel , BS c-Rel , NF-kappaB , NF-kappaB , NF-kappaB(-like) BS , NF-kappaB1 , RelA , RelA , v-Rel BS , NF-kappaB1 . BS -171 -161 R01059; MOUSE$M1H2KB_07; Binding factors: NF-kappaB2 BS , MBP-1 (1) , NF-kappaB1 , NF-kappaB2 precursor BS . BS -170 -162 R01060; MOUSE$M1H2KB_08; Binding factors: MBP-1 (1) , BS NF-kappaB , NF-kappaB , NF-kappaB1 . BS -156 -134 R01061; MOUSE$M1H2KB_09; Binding factors: IBP-1 , BS ICSBP , IRF1 , IRF1 . BS -109 -84 R01062; MOUSE$M1H2KB_10; Binding factors: AP-1 , ATF BS , c-Fos , CREB . BS -90 -64 R02870; MOUSE$M1H2KB_12; Binding factors: EFI . XX DR EMBL: M11847; MMMHKBA. DR EMBL: X15104; MSH2KBM1. DR TRANSPATH: G000561. DR TRANSCOMPEL: C00348. DR TRRD: 00235. XX RN [1] RX MEDLINE; 92334360. RA Dey A., Thornton A. M., Lonergan M., Weissman S. M., Chamberlain J. W., RA Ozato K. RT Occupancy of upstream regulatory sites in vivo coincides with major RT histocompatibility complex class I gene expression in mouse tissues RL Mol. Cell. Biol. 12:3590- 3599 (1992). RN [2] RX MEDLINE; 91266911. RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [3] RX MEDLINE; 92097537. RA Nielsch U., Zimmer S. G., Babiss L. E. RT Changes in NF-kappaB and ISGF3 binding activities are responsible for RT differences in MHC and beta-IFN gene expression in Ad5- versus RT Ad12-transformed cells RL EMBO J. 10:4169-4175 (1991). RN [4] RX MEDLINE; 91266912. RA Logeat F., Israel N., Ten R., Blank V., Le Bail O., Kourilsky P., Israel A. RT Inhibition of transcription factors belonging to the rel/NF-kappaB family RT by a transdominant negative mutant RL EMBO J. 10:1827-1832 (1991). RN [5] RX MEDLINE; 91224495. RA Keller A. D., Maniatis T. RT Identification and characterization of a novel repressor of beta-interferon RT gene expression RL Genes Dev. 5:868-879 (1991). RN [6] RX MEDLINE; 92017769. RA Baldwin jr A. S., Azizkhan J. C., Jensen D. E., Beg A. A., Coodly L. R. RT Induction of NF-kappaB DNA-binding activity during G0-to-G1 transition in RT mouse fibroblasts RL Mol. Cell. Biol. 11:4943-4951 (1991). RN [7] RX MEDLINE; 91343004. RA Schmid R. M., Perkins N. D., Duckett C. S., Andrews P. C., Nabel G. J. RT Cloning of an NF-kappaB subunit which stimulates HIV transcription in RT synergy with p65 RL Nature 352:733-736 (1991). RN [8] RX MEDLINE; 91187610. RA Mitchelmore C., Traboni C., Cortese R. RT Isolation of two cDNAs encoding zinc finger proteins which bind to the RT alpha1-antitrypsin promoter and to the major histocompatibility complex RT class I enhancer RL Nucleic Acids Res. 19:141-147 (1991). RN [9] RX MEDLINE; 91219442. RA Inoue J.-I., Kerr L. D., Ransone L. J., Bengal E., Hunter T., Verma I. M. RT c-rel activates but v-rel suppresses transcription from kappaB sites RL Proc. Natl. Acad. Sci. USA 88:3715-3719 (1991). RN [10] RX MEDLINE; 90367112. RA Kieran M., Blank V., Logeat F., Vendekerckhove J., Lottspeich F., Bail Le RA O., Urban M. B., Kourilsky P., Baeuerle P., Israel A. RT The DNA binding subunit of NF-kappaB is identical to factor KBF1 and RT homologous to the rel oncogene product RL Cell 62:1007-1018 (1990). RN [11] RX MEDLINE; 90107935. RA Katoh S., Ozawa K., Kondoh S.-I., Soeda E.-I., Israel A., Shiroki K., RA Fujinaga K., Itakura K.-I., Gachelin G., Yokoyama K. RT Identification of sequences responsible for positive and negative RT regulation by E1A in the promoter of H-2Kbm1 class I MHC gene RL EMBO J. 9:127-135 (1990). RN [12] RX MEDLINE; 90169514. RA Fan C.-M., Maniatis T. RT A DNA-binding protein containing two widely separated zinc finger motifs RT that recognize the same DNA sequence RL Genes Dev. 4:29-42 (1990). RN [13] RX MEDLINE; 91093062. RA Faber M., Sealy L. RT Rous sarcoma virus enhancer factor I is a ubiquitous CCAAT transcription RT factor highly related to CBF and NF-Y RL J. Biol. Chem. 265:22243-22254 (1990). RN [14] RX MEDLINE; 90205817. RA Baldwin jr A. S., LeClair K. P., Singh H., Sharp P. A. RT A large protein containing zinc finger domains binds to related sequence RT elements in the enhancers of the class I major histocompatibility complex RT and kappa immunoglobulin genes RL Mol. Cell. Biol. 10:1406-1414 (1990). RN [15] RX MEDLINE; 90318380. RA Pessara U., Koch N. RT Tumor necrosis factor alpha regulates expression of the major RT histocompatibility complex class II-associated invariant chain by binding RT of an NF-kappaB-like factor to a promoter element RL Mol. Cell. Biol. 10:4146-4154 (1990). RN [16] RX MEDLINE; 90251633. RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi RA B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the interferon-inducible RT enhancer element of major histocompatibility complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). RN [17] RX MEDLINE; 91062349. RA Rustgi A. K., van't Veer L., Bernards R. RT Two genes encode factors with NF-kappaB- and H2TF1-like DNA-binding RT properties RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990). RN [18] RX MEDLINE; 89305515. RA Blanar M. A., Baldwin jr A. S., Flavell R. A., Sharp P. A. RT A gamma-interferon-induced factor that binds the interferon response RT sequence of the MHC class I gene, H-2Kb RL EMBO J. 8:1139-1144 (1989). RN [19] RX MEDLINE; 90076144. RA Macchi M., Bornert J.-M., Davidson I., Kanno M., Rosales R., Vigneron M., RA Xiao J.-H., Fromental C., Chambon P. RT The SV40 TC-II(kappaB) enhanson binds ubiquitous and cell type specifically RT inducible nuclear proteins from lymphoid and non-lymphoid cell lines RL EMBO J. 8:4215-4227 (1989). RN [20] RX MEDLINE; 90059981. RA Israel A., Le Bail O., Hatat D., Piette J., Kieran M., Logeat F., Wallach RA D., Fellous M., Kourilsky P. RT TNF stimulates expression of mouse MHC class I genes by inducing an RT NF-kappaB-like enhancer binding activity which displaces constitutive RT factors RL EMBO J. 8:3793-3800 (1989). RN [21] RX MEDLINE; 89128426. RA Clark L., Hay R. T. RT Sequence requirements for specific interaction of an enhancer binding RT protein (EBP1) with DNA RL Nucleic Acids Res. 17:499-516 (1989). RN [22] RX MEDLINE; 89242103. RA Hoyos B., Ballard D. W., Boehnlein E., Siekevitz M., Greene W. C. RT Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human RT Interleukin-2 Gene Expression RL Science 244:457-460 (1989). RN [23] RX MEDLINE; 88124914. RA Baldwin jr A. S., Sharp P. A. RT Two transcription factors, NF-kB and H2TF1, interact with a single RT regulatory sequence in the class I major histocompatibility complex promoter RL Proc. Natl. Acad. Sci. USA 85:723-727 (1988). RN [24] RX MEDLINE; 88027009. RA Imagawa M., Chiu R., Karin M. RT Transcription factor AP-2 mediates induction by two different signal RT transduction pathways: Protein kinase C and cAMP RL Cell 51:251-260 (1987). RN [25] RX MEDLINE; 88111518. RA Yano O., Kanellopoulos J., Kieran M., Le Bail O., Israel A., Kourilsky P. RT Purification of KBF1, a common factor binding to both H-2 and RT beta2-microglobulin enhancers RL EMBO J. 6:3317-3324 (1987). RN [26] RX MEDLINE; 87172719. RA Baldwin jr A. S., Sharp P. A. RT Binding of a Nuclear Factor to a Regulatory Sequence in the Promoter of the RT Mouse H-2Kb Class I Major Histocompatibility Gene RL Mol. Cell. Biol. 7:305-313 (1987). RN [27] RX MEDLINE; 87204189. RA Israel A., Kimura A., Kieran M., Yanu O., Kanellopoulos J., Le Bail O., RA Kourilsky P. RT A common positive trans-acting factor binds to enhancer sequences in the RT promoters of mouse H-2 and beta2-microglobulin genes RL Proc. Natl. Acad. Sci. USA 84:2653-2657 (1987). XX // AC G000562 XX ID MOUSE$M1H2KK XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD H-2Kk XX DE MHC class I H-2Kk XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.1 XX BS empty empty R02337; MOUSE$M1H2KK_02. BS -165 0 R02336; MOUSE$M1H2KK_01; Binding factors: NF-kappaB1 . XX DR TRANSPATH: G000562. DR TRRD: 00236. XX RN [1] RX MEDLINE; 90318374. RA Henseling U., Schmidt W., Schoeler H. R., Gruss P., Hatzopoulos A. K. RT A transcription factor interacting with the class I gene enhancer is RT inactive in tumorigenic cell lines which suppress major histocompatibility RT complex class I genes RL Mol. Cell. Biol. 10:4100-4109 (1990). XX // AC G000563 XX ID MOUSE$M1H2LD XX DT 14.06.1995 (created); dbo. DT 16.04.2002 (updated); oke. CO Copyright (C), Biobase GmbH. XX SD H-2Ld XX DE MHC class I H-2Ld XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.1 XX BS -200 -191 R01063; MOUSE$M1H2LD_01; Binding factors: RAR-beta , BS RXR-beta . BS -188 -179 R01064; MOUSE$M1H2LD_02. BS -174 -162 R01065; MOUSE$M1H2LD_03; Binding factors: NF-kappaB(-like) BS , NF-kappaB1 . BS -152 -142 R01066; MOUSE$M1H2LD_04; Binding factors: ICSBP . XX DR EMBL: M12483; MMMHLDC. DR TRANSPATH: G000563. DR TRANSCOMPEL: C00340. DR TRRD: 00237. XX RN [1] RX MEDLINE; 94019290. RA Segars J. H., Nagata T., Bours V., Medin J. A., Franzoso G., Blanco J. C. RA B., Drew P. D., Becker K. G., An F., Tang T., Stephany D. A., Neel B., RA Siebenlist U., Ozato K. RT Retinoic acid induction of major histocompatibility complex class I genes RT in NTera-1 embryonal carcinoma cells involves induction of NF-kappaB RT (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta RT heterodimers RL Mol. Cell. Biol. 13:6157-6169 (1993). RN [2] RX MEDLINE; 93094349. RA Massa P. T., Hirschfeld S., Levi B. Z., Quigley L. A., Ozato K., McFarlin RA D. E. RT Expression of major hiscompatibility complex (MHC) class I genes in RT astrocytes correlates with the presence of nuclear factors that bind to RT constitutive and inducible enhacers RL J. Neuroimmunol. 41:35-42 (1992). RN [3] RX MEDLINE; 88320348. RA Shirayoshi Y., Burke P. A., Appella E., Ozato K. RT Interferon-induced transcription of a major histocompatibility class I gene RT accompanies binding of inducible nuclear factors to the interferon RT consensus sequence RL Proc. Natl. Acad. Sci. USA 85:5884-5888 (1988). RN [4] RX MEDLINE; 88142847. RA Shirayoshi Y., Miyazaki J.-I., Burke P. A., Hamada K., Appella E., Ozato K. RT Binding of Multiple Nuclear Factors to the 5' Upstream Regulatory Element RT of the Murine Major Histocompatibility Class I Gene RL Mol. Cell. Biol. 7:4542-4548 (1987). XX // AC G000564 XX ID MOUSE$M2EAD XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Ealphad XX DE MHC class II Ealphad XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.2 XX BS -1809 -1714 R01071; MOUSE$M2EAD_01; Binding factors: NF-kappaB , BS NF-kappaB1 . BS -1219 -1182 R01072; MOUSE$M2EAD_02; Binding factors: NF-W1 . BS -1219 -1182 R01073; MOUSE$M2EAD_03; Binding factors: NF-W2 . XX DR EMBL: M18158; MMMHIEDA. DR TRANSPATH: G000564. DR TRRD: 00224. XX RN [1] RX MEDLINE; 89219082. RA Blanar M. A., Burkly L. C., Flavell R. A. RT NF-kB Binds within a Region Required for B-Cell-Specific Expression of the RT Major Histocompatibility Complex Class II Gene E RL Mol. Cell. Biol. 9:844-846 (1989). RN [2] RX MEDLINE; 89181584. RA Dorn A., Benoist C., Mathis D. RT New B-Lymphocyte-Specific Enhancer-Binding Protein RL Mol. Cell. Biol. 9:312-320 (1989). XX // AC G000565 XX ID MOUSE$M2EB XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Ebeta XX DE MHC class II Ebeta XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.2 XX BS empty empty R02992; MOUSE$M2EB_04. BS -160 -130 R01082; MOUSE$M2EB_01. BS -120 0 R01083; MOUSE$M2EB_02. BS -107 -85 R01084; MOUSE$M2EB_03. XX DR EMBL: M11800; MMMHCAB1. DR EMBL: K00123; MMMHEB1. DR EMBL: M35677; MMMHEBF1. DR EMBL: M35680; MMMHEBQ1. DR TRRD: 00239. XX RN [1] RX MEDLINE; 91172164. RA Shenkar R., Shen M., Arnheim N. RT DNase I-hypersensitive sites and transcription factor-binding motifs within RT the mouse Ebeta meiotic recombination hot spot RL Mol. Cell. Biol. 11:1813-1819 (1991). RN [2] RX MEDLINE; 90228354. RA Finn P. W., Kara C. J., Van T. T., Douhan III J., Boothby M. R., Glimcher RA L. H. RT The presence of a DNA binding complex correlates with Ebeta class II MHC RT gene expression RL EMBO J. 9:1543-1549 (1990). RN [3] RX MEDLINE; 90097940. RA Celada A., Maki R. RT Evidence for Multiple Major Histocompatibility Class II X-Box Binding RT Proteins RL Mol. Cell. Biol. 9:5219-5922 (1989). XX // AC G000566 XX ID MOUSE$M2EAK XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD Ekalpha XX DE MHC class II Ekalpha XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.2 XX BS -1824 -1803 R01074; MOUSE$M2EAK_01. BS -1713 -1674 R01075; MOUSE$M2EAK_02. BS -1404 -1366 R01076; MOUSE$M2EAK_03; Binding factors: NF-Y . BS -1241 -1230 R01077; MOUSE$M2EAK_04. BS -105 -68 R01078; MOUSE$M2EAK_05. BS -86 0 R01079; MOUSE$M2EAK_06; Binding factors: X-box binding protein BS , NF-X , NF-X . BS -74 -36 R01080; MOUSE$M2EAK_07; Binding factors: NF-Y . BS -65 -49 R01081; MOUSE$M2EAK_08; Binding factors: NF-Y . XX DR EMBL: M17389; MMMHEKA. DR EMBL: K00971; MMMHIEAD. DR EMBL: M18158; MMMHIEDA. DR TRANSPATH: G000566. DR TRRD: 00226. XX RN [1] RX MEDLINE; 92371439. RA Mantovani R., Pessara U., Tronche F., Li X.-Y., Knapp A.-M., Pasquali RA J.-L., Benoist C., Mathis D. RT Monoclonal antibodies to NF-Y define its function in MHC class II and RT albumin gene transcription RL EMBO J. 11:3315-3322 (1992). RN [2] RX MEDLINE; 91201893. RA Kouskoff V., Mantovani R. M., Candeias S. M., Dorn A., Staub A., RA Lisowska-Grospierre B., Griscelli C., Benoist C. O., Mathis D. J. RT NF-X, a transcription factor implicated in MHC class II gene regulation RL J. Immunol. 146:3197-3204 (1991). RN [3] RX MEDLINE; 91094877. RA Kern M. J., Woodward J. G. RT The same CCAAT box-binding factor binds to the promoter of two coordinately RT regulated major histocompatibility complex class II genes RL Mol. Cell. Biol. 11:578-581 (1991). RN [4] RX MEDLINE; 91006004. RA Hooft van Huijsduijnen R., Li X. Y., Black D., Matthes H., Benoist C., RA Mathis D. RT Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) RT subunits RL EMBO J. 9:3119-3127 (1990). RN [5] RX MEDLINE; 90318380. RA Pessara U., Koch N. RT Tumor necrosis factor alpha regulates expression of the major RT histocompatibility complex class II-associated invariant chain by binding RT of an NF-kappaB-like factor to a promoter element RL Mol. Cell. Biol. 10:4146-4154 (1990). RN [6] RX MEDLINE; 90097940. RA Celada A., Maki R. RT Evidence for Multiple Major Histocompatibility Class II X-Box Binding RT Proteins RL Mol. Cell. Biol. 9:5219-5922 (1989). RN [7] RX MEDLINE; 89039821. RA Dorn A., Fehling H. J., Koch W., Le Meur M., Gerlinger P., Benoist C., RA Mathis D. RT B-Cell Control Region at the 5' End of a Major Histocompatibility Complex RT Class II Gene: Sequences and Factors RL Mol. Cell. Biol. 8:3975-3987 (1988). RN [8] RX MEDLINE; 87301730. RA Dorn A., Bollekens J., Staub A., Benoist C., Mathis D. RT A Multiplicity of CCAAT Box-Binding Proteins RL Cell 50:863-872 (1987). RN [9] RX MEDLINE; 87317630. RA Dorn A., Durand B., Marfing C., Le Meur M., Benoist C., Mathis D. RT Conserved major histocompatibility complex class II boxes-X and Y-are RT transcriptional control elements and specifically bind nuclear proteins RL Proc. Natl. Acad. Sci. USA 84:6249-6253 (1987). XX // AC G000567 XX ID MOUSE$M2IAA XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD I-Aalpha XX DE MHC class II I-Aalpha XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.2 XX BS empty empty R01810; MOUSE$M2IAA_02. BS -152 -142 R01067; MOUSE$M2IAA_01; Binding factors: c-Jun , BS CRE-BP1 , CRE-BP2 . BS -106 -92 R01937; MOUSE$M2IAA_03; Binding factors: NF-H1 . BS -106 -92 R01938; MOUSE$M2IAA_04; Binding factors: NF-H2 , BS NF-H3 . BS -85 -74 R01939; MOUSE$M2IAA_05; Binding factors: NF-X , NF-X BS . BS -85 -74 R01940; MOUSE$M2IAA_06; Binding factors: RFX , NF-X BS , RFX1 , RFX2 , RFX2 , RFX3 , RFX3 BS , RFX1 . BS -72 -64 R01941; MOUSE$M2IAA_07; Binding factors: CRE-BP2 , BS XBP-2 , XBP-3 . BS -42 -35 R01942; MOUSE$M2IAA_08; Binding factors: NF-Y . XX DR EMBL: M24602; MMMHAA. DR TRANSPATH: G000567. DR TRRD: 00240. XX RN [1] RX MEDLINE; 90205841. RA Ivashkiv L. B., Liou H.-C., Kara C. J., Lamph W. W., Verma I. M., Glimcher RA L. H. RT mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but RT not to the 12-O-tetradecanoylphorbol-13-acetate, response element RL Mol. Cell. Biol. 10:1609-1621 (1990). RN [2] RX MEDLINE; 90136573. RA Dedrick R. L., Jones P. P. RT Sequence Elements Required for Activity of a Murine Major RT Histocompatibility Complex Class II Promoter Bind Common and RT Cell-Type-Specific Nuclear Factors RL Mol. Cell. Biol. 10:593-604 (1990). RN [3] RX MEDLINE; 90205810. RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H. RT A cDNA for a human cyclic AMP response element-binding protein which is RT distinct from CREB and expressed preferentially in brain RL Mol. Cell. Biol. 10:1347-1357 (1990). RN [4] RX MEDLINE; 90097940. RA Celada A., Maki R. RT Evidence for Multiple Major Histocompatibility Class II X-Box Binding RT Proteins RL Mol. Cell. Biol. 9:5219-5922 (1989). XX // AC G000568 XX ID MOUSE$M2IAB XX DT 14.06.1995 (created); dbo. DT 18.03.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD I-Abeta XX DE MHC class II I-Abeta XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.2 XX BS empty empty R01808; MOUSE$M2IAB_02. BS empty empty R01809; MOUSE$M2IAB_03. BS -76 -46 R01068; MOUSE$M2IAB_01; Binding factors: PU.1 , PU.1 BS . XX DR EMBL: M20195; MMMH1ABA. DR EMBL: M20196; MMMH1ABB. DR EMBL: K00007; MMMHABZ1. DR TRANSPATH: G000568. XX RN [1] RX MEDLINE; 91094877. RA Kern M. J., Woodward J. G. RT The same CCAAT box-binding factor binds to the promoter of two coordinately RT regulated major histocompatibility complex class II genes RL Mol. Cell. Biol. 11:578-581 (1991). RN [2] RX MEDLINE; 90199884. RA Klemsz M. J., McKercher S. R., Celada A., van Beveren C., Maki R. A. RT The macrophage and B cell-specific transcription factor PU.1 is related to RT the ets oncogene RL Cell 61:113-124 (1990). RN [3] RX MEDLINE; 89384572. RA Celada A., Maki R. A. RT DNA binding of the mouse class II major histocompatibility CCAAT factor RT depends on two components RL Mol. Cell. Biol. 9:3097-3100 (1989). RN [4] RX MEDLINE; 90097940. RA Celada A., Maki R. RT Evidence for Multiple Major Histocompatibility Class II X-Box Binding RT Proteins RL Mol. Cell. Biol. 9:5219-5922 (1989). XX // AC G000569 XX ID MOUSE$M2AAD XX DT 14.06.1995 (created); dbo. DT 21.05.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IaAalphad XX DE MHC class II Ia Aalphad XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.2 XX BS -73 -44 R03700; MOUSE$M2AAD_01; Binding factors: COE1 . XX DR TRANSPATH: G000569. DR TRRD: 00238. XX RN [1] RX MEDLINE; 92007792. RA Hagman J., Travis A., Grosschedl R. RT A novel lineage-specific nuclear factor regulates mb-1 gene transcription RT at the early stages of B cell differentiation RL EMBO J. 10:3409-3417 (1991). XX // AC G000570 XX ID MOUSE$M2AAK XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD IaAalphaK XX DE MHC class II Ia Aalphak XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.2 XX BS -1210 -1157 R01749; MOUSE$M2AAK_01. XX DR EMBL: M24602; MMMHAA. XX RN [1] RX MEDLINE; 90014771. RA Gravallese E. M., Boothby M. R., Smas C. M., Glimcher L. H. RT A Lipopolysaccharide-Induced DNA-Binding Protein for a Class II Gene in B RT Cells is Distinct from NF-kB RL Mol. Cell. Biol. 9:3184-3192 (1989). XX // AC G000571 XX ID MOUSE$MHC2IN XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD Ii XX DE MHC class II invariant chain XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.3.2 XX BS -121 -111 R02338; MOUSE$MHC2IN_01; Binding factors: NF-kappaB(-like) BS , NF-TNF , NF-TNF . XX DR TRANSPATH: G000571. DR TRRD: 00126. XX RN [1] RX MEDLINE; 90318380. RA Pessara U., Koch N. RT Tumor necrosis factor alpha regulates expression of the major RT histocompatibility complex class II-associated invariant chain by binding RT of an NF-kappaB-like factor to a promoter element RL Mol. Cell. Biol. 10:4146-4154 (1990). XX // AC G000572 XX ID MOUSE$MRP XX DT 14.06.1995 (created); dbo. DT 25.04.1996 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MRP XX DE mitochondrial RNA processing RNA XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -307 -297 R02671; MOUSE$MRP_01; Binding factors: NRF-1 , NRF-1 BS . XX DR EMBL: J03151; MMMRP. DR TRANSPATH: G000572. XX RN [1] RX MEDLINE; 90346283. RA Evans M. J., Scarpulla R. C. RT NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal RT cells RL Genes Dev. 4:1023-1034 (1990). XX // AC G000573 XX ID MOUSE$MMDH XX DT 14.06.1995 (created); dbo. DT 24.01.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX SD mMDH XX DE mitochondrial malate dehydrogenase XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BS -348 -311 R04284; MOUSE$MMDH_01. XX DR EMBL: X07295; MMDH1. DR BRENDA: 1.1.1.37. XX RN [1] RX MEDLINE; 92375073. RA Suzuki-Yagawa Y., Kawakami K., Nagano K. RT Housekeeping Na,K-ATPase alpha1 subunit gene promoter is composed of RT multiple cis elements to which common and cell type-specific factors bind RL Mol. Cell. Biol. 12:4046-4055 (1992). XX // AC G000574 XX ID MOUSE$IGH141 XX DT 21.05.1996 (created); ake. DT 21.05.1996 (updated); ake. CO Copyright (C), Biobase GmbH. XX SD MOPC 141 XX DE immunoglobulin heavy-chain gene XX OS mouse, Mus hortulans OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.6.5.1.1 XX DR TRANSCOMPEL: C00050. XX // AC G000575 XX ID MOUSE$MDR1 XX DT 21.05.1996 (created); ake. DT 16.10.2001 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD mdr1 XX DE multi-drug resistance 1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.3.11 XX BS -197 -178 R11278; MOUSE$MDR1_01; Binding factors: p53 . XX DR EMBL: M60348; MMMDR1. DR TRANSPATH: G000575. DR TRRD: 00172. XX RN [1] RX MEDLINE; 21264998. RA Mathieu M. C., Lapierre I., Brault K., Raymond M. RT Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and RT p53-mediated induction of the murine multidrug resistance mdr1 gene by RT 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells. RL J. Biol. Chem. 276:4819-4827 (2001). XX // AC G000576 XX ID MOUSE$MYOD XX DT 14.06.1995 (created); dbo. DT 13.05.1997 (updated); dbo. CO Copyright (C), Biobase GmbH. XX SD MyoD XX DE myogenic differentiation master gene G558MyoD1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.2.2.4 XX BS -341 -322 R08476; MOUSE$MYOD_03; Binding factors: AP-1 . BS -337 -309 R08504; MOUSE$MYOD_04; Binding factors: ARP-1 , BS RXR-gamma , RXR-alpha , T3R-alpha . BS -119 -100 R04160; MOUSE$MYOD_01; Binding factors: Sp1 , Sp1 BS . BS -103 -90 R04161; MOUSE$MYOD_02. XX DR EMBL: X61655; MMMYOD1. DR TRANSPATH: G000576. DR TRRD: 00046. XX RN [1] RX MEDLINE; 95273166. RA Muscat G. E. O., Rea S., Downes M. RT Identification of a regulatory function for an orphan receptor in muscle: RT COUP-TF II affects the expression of the myoD gene family during myogenesis RL Nucleic Acids Res. 23:1311-1318 (1995). RN [2] RX MEDLINE; 94173724. RA Muscat G. E. O., Mynett-Johnson L., Dowhan D., Downes M., Griggs R. RT Activation of MyoD gene transcription by 3, 4, 3'-triiodo-L-thyronine: a RT direct role for the thyroid hormone and retinoid X receptors RL Nucleic Acids Res. 22:583-591 (1994). RN [3] RX MEDLINE; 94165103. RA Pedraza-Alva G., Zingg J. M., Jost J. P. RT AP-1 binds to a putative cAMP response element of the MyoD1 promoter and RT negatively modulates MyoD1 expression in dividing myoblasts RL J. Biol. Chem. 269:6978-6985 (1994). RN [4] RX MEDLINE; 93024445. RA Tapscott S. J., Lassar A. B., Weintraub H. RT A novel myoblast enhancer element mediates MyoD transcription RL Mol. Cell. Biol. 12:4994-5003 (1992). XX // AC G000577 XX ID MOUSE$NRAS XX DT 14.06.1995 (created); dbo. DT 13.11.2000 (updated); vma. CO Copyright (C), Biobase GmbH. XX SD N-ras XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; OC eutheria; rodentia; myomorpha; muridae; murinae XX BC 6.1.5.15 XX BS -189 -176 R03008; MOUSE$NRAS_01. BS -148 0 R03009; MOUSE$NRAS_02. XX DR EMBL: X06909; MMNRASG. XX RN [1] RX MEDLINE; 91141481. RA Paciucci R., Pellicer A.