VV TRANSFAC CLASS TABLE, Release 6.2 - licensed - 2002-07-01, (C) Biobase GmbH XX // AC C0001 XX ID CH XX DT 25.09.1993 (created); ewi. DT 02.03.1995 (updated); dbo. CO Copyright (C), Biobase GmbH. XX CL zinc finger XX CC Zinc finger motif of TFIIIA/Krueppel type. Each finger comprises 2 cysteine CC and 2 histidine residues coordinating one zinc ion, in some cases one CC histidine is replaced by another cysteine. The zinc ion is essential for CC DNA-binding. The first half of the finger sequence is generally organized CC in two antiparallel beta-strands, the second half as an alpha-helix and CC partly as an 310-helix. Hydrophobic contacts between the beta-strands and CC the alpha-helix are formed by the conserved phenylalanine and leucine CC residues. The alpha-helix binds to DNA through the major groove. The finger CC link frequently is TGEKPY. XX BF T00002; ACE2; Species: yeast, Saccharomyces cerevisiae. BF T00011; ADR1; Species: yeast, Saccharomyces cerevisiae. BF T01513; AEF-1; Species: fruit fly, Drosophila melanogaster. BF T00016; AGIE-BP1; Species: rat, Rattus norvegicus. BF T00007; alphaA-CRYBP1; Species: mouse, Mus musculus. BF T02847; AMDA; Species: Aspergillus nidulans, Emericella nidulans. BF T04686; AP-2rep; Species: human, Homo sapiens. BF T01015; AT-BP1; Species: rat, Rattus norvegicus. BF T02276; ATBP; Species: flesh fly, Sarcophaga peregrina. BF T03202; AZF1; Species: yeast, Saccharomyces cerevisiae. BF T02322; BCL-6; Species: human, Homo sapiens. BF T02316; Blimp-1; Species: mouse, Mus musculus. BF T01477; BR-C Z1; Species: fruit fly, Drosophila melanogaster. BF T01478; BR-C Z2; Species: fruit fly, Drosophila melanogaster. BF T01479; BR-C Z3; Species: fruit fly, Drosophila melanogaster. BF T01480; BR-C Z4; Species: fruit fly, Drosophila melanogaster. BF T04868; BR140; Species: human, Homo sapiens. BF T00069; BrlA; Species: Aspergillus nidulans, Emericella nidulans. BF T02372; Btd; Species: fruit fly, Drosophila melanogaster. BF T02210; BTEB1; Species: rat, Rattus norvegicus. BF T02212; BTEB1; Species: human, Homo sapiens. BF T04700; BTEB1; Species: mouse, Mus musculus. BF T02211; BTEB2; Species: human, Homo sapiens. BF T05054; BTEB2; Species: mouse, Mus musculus. BF T05051; BTEB3; Species: human, Homo sapiens. BF T05052; BTEB3; Species: mouse, Mus musculus. BF T05053; BTEB4; Species: mouse, Mus musculus. BF T00072; byr3; Species: fission yeast, Schizosaccharomyces pombe. BF T02314; BZP; Species: golden hamster, Mesocricetus auratus. BF T00077; CACCC-binding factor; Species: human, Homo sapiens. BF T00119; CF2-I; Species: fruit fly, Drosophila melanogaster. BF T00120; CF2-II; Species: fruit fly, Drosophila melanogaster. BF T00121; CF2-III; Species: fruit fly, Drosophila melanogaster. BF T05138; CIZ5; Species: rat, Rattus norvegicus. BF T05137; CIZ6-1; Species: rat, Rattus norvegicus. BF T05141; CIZ6-2; Species: rat, Rattus norvegicus. BF T05142; CIZ6-3; Species: rat, Rattus norvegicus. BF T05136; CIZ8; Species: rat, Rattus norvegicus. BF T02854; CNBP; Species: human, Homo sapiens. BF T04964; CPBP; Species: human, Homo sapiens. BF T00162; CreA; Species: Aspergillus nidulans, Emericella nidulans. BF T03231; CRZ1; Species: yeast, Saccharomyces cerevisiae. BF T00172; CTCF; Species: chick, Gallus gallus. BF T02284; CTCF; Species: human, Homo sapiens. BF T02285; CTCF; Species: mouse, Mus musculus. BF T02365; DB1; Species: human, Homo sapiens. BF T00278; delta factor; Species: mouse, Mus musculus. BF T00244; Egr-1; Species: mouse, Mus musculus. BF T01200; Egr-1; Species: rat, Rattus norvegicus. BF T00241; EGR1; Species: human, Homo sapiens. BF T00242; EGR2; Species: human, Homo sapiens. BF T00243; EGR3; Species: human, Homo sapiens. BF T01676; EKLF; Species: mouse, Mus musculus. BF T04957; EKLF; Species: human, Homo sapiens. BF T02448; EPF2-4; Species: Petunia hybrida. BF T02329; esg; Species: fruit fly, Drosophila melanogaster. BF T00273; Evi-1; Species: mouse, Mus musculus. BF T04682; FAC1; Species: human, Homo sapiens. BF T04956; FKLF; Species: human, Homo sapiens. BF T02334; FOG; Species: mouse, Mus musculus. BF T03312; FZF1; Species: yeast, Saccharomyces cerevisiae. BF T00301; GAGA factor; Species: fruit fly, Drosophila melanogaster. BF T01921; Gfi-1; Species: rat, Rattus norvegicus. BF T03402; GIS1; Species: yeast, Saccharomyces cerevisiae. BF T02450; GKLF; Species: mouse, Mus musculus. BF T04959; GKLF; Species: human, Homo sapiens. BF T00329; Glass; Species: fruit fly, Drosophila melanogaster. BF T02282; Glass; Species: fruit fly, Drosophila virilis. BF T00330; GLI; Species: human, Homo sapiens. BF T04961; GLI2; Species: human, Homo sapiens. BF T00331; GLI3; Species: human, Homo sapiens. BF T05131; GLIS2; Species: human, Homo sapiens. BF T00395; Hb; Species: fruit fly, Drosophila melanogaster. BF T04954; Helios; Species: human, Homo sapiens. BF T00939; HIV-EP2; Species: human, Homo sapiens. BF T03448; HMS1; Species: yeast, Saccharomyces cerevisiae. BF T03994; ID1; Species: maize, Zea mays. BF T01469; Ik-1; Species: mouse, Mus musculus. BF T02703; Ik-1; Species: rainbow trout, Oncorhynchus mykiss. BF T01470; Ik-2; Species: mouse, Mus musculus. BF T02704; Ik-2; Species: rainbow trout, Oncorhynchus mykiss. BF T01471; Ik-3; Species: mouse, Mus musculus. BF T02705; Ik-3; Species: rainbow trout, Oncorhynchus mykiss. BF T01472; Ik-4; Species: mouse, Mus musculus. BF T02706; Ik-4; Species: rainbow trout, Oncorhynchus mykiss. BF T01473; Ik-5; Species: mouse, Mus musculus. BF T02707; Ik-5; Species: rainbow trout, Oncorhynchus mykiss. BF T02709; Ik-6; Species: rainbow trout, Oncorhynchus mykiss. BF T02708; Ik-7; Species: rainbow trout, Oncorhynchus mykiss. BF T02710; Ik-8; Species: rainbow trout, Oncorhynchus mykiss. BF T00441; KBP-1; Species: human, Homo sapiens. BF T02326; Kid-1; Species: rat, Rattus norvegicus. BF T05074; KLF14; Species: mouse, Mus musculus. BF T05058; KLF15; Species: human, Homo sapiens. BF T02283; Kox1; Species: human, Homo sapiens. BF T00456; Kr; Species: fruit fly, Drosophila melanogaster. BF T04971; KR3; Species: human, Homo sapiens. BF T00454; Krox-20; Species: mouse, Mus musculus. BF T00455; Krox-24; Species: mouse, Mus musculus. BF T00457; KUP; Species: human, Homo sapiens. BF T03602; lin-26A; Species: Caenorhabditis elegans. BF T03603; lin-26B; Species: Caenorhabditis elegans. BF T03610; lin-26B; Species: Caenorhabditis briggsae. BF T03585; lin-29A; Species: Caenorhabditis elegans. BF T03586; lin-29B; Species: Caenorhabditis elegans. BF T03604; lir-1A; Species: Caenorhabditis elegans. BF T03606; lir-1A; Species: Caenorhabditis briggsae. BF T03605; lir-1C; Species: Caenorhabditis elegans. BF T03609; lir-2; Species: Caenorhabditis briggsae. BF T03607; lir-2A; Species: Caenorhabditis elegans. BF T03608; lir-2B; Species: Caenorhabditis elegans. BF T03611; lir-3; Species: Caenorhabditis elegans. BF T01677; LKLF; Species: mouse, Mus musculus. BF T01678; LKLF; Species: rat, Rattus norvegicus. BF T04958; LKLF; Species: human, Homo sapiens. BF T00479; LyF-1; Species: mouse, Mus musculus. BF T02702; LyF-1; Species: human, Homo sapiens. BF T00490; MAZ; Species: human, Homo sapiens. BF T02303; MAZ; Species: mouse, Mus musculus. BF T02304; MAZ; Species: golden hamster, Mesocricetus auratus. BF T02305; MAZi; Species: human, Homo sapiens. BF T04796; MAZR; Species: mouse, Mus musculus. BF T04797; MAZR; Species: human, Homo sapiens. BF T00497; MBP-1 (1); Species: human, Homo sapiens. BF T00496; MBP-2; Species: human, Homo sapiens. BF T03494; MET31; Species: yeast, Saccharomyces cerevisiae. BF T03495; MET32; Species: yeast, Saccharomyces cerevisiae. BF T02313; MIBP1; Species: rat, Rattus norvegicus. BF T00509; MIG1; Species: yeast, Saccharomyces cerevisiae. BF T03498; MIG2; Species: yeast, Saccharomyces cerevisiae. BF T03414; Miz-1; Species: human, Homo sapiens. BF T02335; MKR2; Species: mouse, Mus musculus. BF T00510; MOK-2; Species: mouse, Mus musculus. BF T03500; MOT3; Species: yeast, Saccharomyces cerevisiae. BF T01257; MSN2; Species: yeast, Saccharomyces cerevisiae. BF T01258; MSN4; Species: yeast, Saccharomyces cerevisiae. BF T02286; MTB-Zf; Species: human, Homo sapiens. BF T00515; MTF-1; Species: mouse, Mus musculus. BF T02354; MTF-1; Species: human, Homo sapiens. BF T00529; MZF-1; Species: human, Homo sapiens. BF T00620; NGFI-C; Species: rat, Rattus norvegicus. BF T03516; NRG1; Species: yeast, Saccharomyces cerevisiae. BF T01974; NRSF form 1; Species: human, Homo sapiens. BF T01973; NRSF form 2; Species: human, Homo sapiens. BF T00667; Odd; Species: fruit fly, Drosophila melanogaster. BF T04672; Opa; Species: fruit fly, Drosophila melanogaster. BF T00669; Ovo-B; Species: fruit fly, Drosophila melanogaster. BF T02323; OZF; Species: human, Homo sapiens. BF T01679; PacC; Species: Aspergillus nidulans, Emericella nidulans. BF T03543; pag-3; Species: Caenorhabditis elegans. BF T03544; pag-3; Species: Caenorhabditis briggsae. BF T03970; PCP1; Species: potato, Solanum tuberosum. BF T02287; phiAP3; Species: mouse, Mus musculus. BF T03431; pie-1; Species: Caenorhabditis elegans. BF T04962; PLAGL1; Species: human, Homo sapiens. BF T04963; PLAGL2; Species: human, Homo sapiens. BF T02336; PLZF; Species: human, Homo sapiens. BF T00929; PRDI-BF1; Species: human, Homo sapiens. BF T03530; PZF1; Species: yeast, Saccharomyces cerevisiae. BF T02315; Rc; Species: mouse, Mus musculus. BF T04219; rep2; Species: fission yeast, Schizosaccharomyces pombe. BF T00727; REX-1; Species: mouse, Mus musculus. BF T01292; RIM101; Species: yeast, Saccharomyces cerevisiae. BF T00731; RME1; Species: yeast, Saccharomyces cerevisiae. BF T02815; Roaz; Species: rat, Rattus norvegicus. BF T05040; RP58; Species: human, Homo sapiens. BF T03423; RPH1; Species: yeast, Saccharomyces cerevisiae. BF T01975; RREB-1; Species: human, Homo sapiens. BF T05025; SAF-1; Species: rabbit, Oryctolagus cuniculus. BF T05035; SAF-1; Species: mouse, Mus musculus. BF T05027; SAF-5; Species: rabbit, Oryctolagus cuniculus. BF T05036; SAF-5; Species: mouse, Mus musculus. BF T05028; SAF-8; Species: rabbit, Oryctolagus cuniculus. BF T05037; SAF-8; Species: mouse, Mus musculus. BF T00742; Sdc-1; Species: Caenorhabditis elegans. BF T02278; SEM-4; Species: Caenorhabditis elegans. BF T02332; Shn; Species: fruit fly, Drosophila melanogaster. BF T05005; SLUG; Species: human, Homo sapiens. BF T00751; Sn; Species: fruit fly, Drosophila melanogaster. BF T02333; Sna; Species: mouse, Mus musculus. BF T00752; Sp1; Species: mouse, Mus musculus. BF T00754; Sp1; Species: rat, Rattus norvegicus. BF T00755; Sp1; Species: chick, Gallus gallus. BF T00757; Sp1; Species: monkey, Cercopithecus aethiops. BF T00759; Sp1; Species: human, Homo sapiens. BF T02356; Sp2; Species: human, Homo sapiens. BF T02338; Sp3; Species: human, Homo sapiens. BF T02453; Sp3; Species: rat, Rattus norvegicus. BF T02339; Sp4; Species: human, Homo sapiens. BF T02414; Sp4; Species: mouse, Mus musculus. BF T02456; Sp4; Species: rat, Rattus norvegicus. BF T03658; SPS18; Species: yeast, Saccharomyces cerevisiae. BF T02321; SRE-ZBP; Species: human, Homo sapiens. BF T00768; Sry h-1; Species: fruit fly, Drosophila melanogaster. BF T00769; Sry-beta; Species: fruit fly, Drosophila melanogaster. BF T00767; Sry-delta; Species: fruit fly, Drosophila melanogaster. BF T02247; Staf; Species: clawed frog, Xenopus laevis. BF T02402; STP1; Species: yeast, Saccharomyces cerevisiae. BF T04606; STP2; Species: yeast, Saccharomyces cerevisiae. BF T03971; STZ; Species: thale cress, Arabidopsis thaliana. BF T00774; su(Hw); Species: fruit fly, Drosophila melanogaster. BF T02275; SUP; Species: thale cress, Arabidopsis thaliana. BF T00776; SWI5; Species: yeast, Saccharomyces cerevisiae. BF T00788; T-Ag; Species: SV40, simian virus 40. BF T02295; TFIIIA; Species: clawed frog, Xenopus. BF T04953; TFIIIA; Species: human, Homo sapiens. BF T04955; TIEG-1; Species: human, Homo sapiens. BF T00842; Tra-1 (long form); Species: Caenorhabditis elegans. BF T00845; Tra-1 (short form); Species: Caenorhabditis elegans. BF T00805; Tsh; Species: fruit fly, Drosophila melanogaster. BF T00843; Ttk 69K; Species: fruit fly, Drosophila melanogaster. BF T00844; Ttk 88K; Species: fruit fly, Drosophila melanogaster. BF T01691; TTP; Species: mouse, Mus musculus. BF T03711; USV1; Species: yeast, Saccharomyces cerevisiae. BF T00899; WT1; Species: human, Homo sapiens. BF T02351; WT1; Species: mouse, Mus musculus. BF T02352; WT1; Species: rat, Rattus norvegicus. BF T01839; WT1 -KTS; Species: human, Homo sapiens. BF T01840; WT1 I; Species: human, Homo sapiens. BF T00900; WT1 I -KTS; Species: human, Homo sapiens. BF T01842; WT1 I-del2; Species: human, Homo sapiens. BF T01841; WT1-del2; Species: human, Homo sapiens. BF T02341; WZF1; Species: wheat, Triticum aestivum. BF T02366; XFG20; Species: clawed frog, Xenopus laevis. BF T00865; YY1; Species: mouse, Mus musculus. BF T00915; YY1; Species: human, Homo sapiens. BF T03717; ZAP1; Species: yeast, Saccharomyces cerevisiae. BF T03904; ZAT1; Species: thale cress, Arabidopsis thaliana. BF T03909; ZAT10; Species: thale cress, Arabidopsis thaliana. BF T03913; ZAT11; Species: thale cress, Arabidopsis thaliana. BF T03910; ZAT12; Species: thale cress, Arabidopsis thaliana. BF T03906; ZAT5; Species: thale cress, Arabidopsis thaliana. BF T03908; ZAT7; Species: thale cress, Arabidopsis thaliana. BF T04996; ZBP89; Species: human, Homo sapiens. BF T04995; ZBP99; Species: human, Homo sapiens. BF T02324; ZEB; Species: human, Homo sapiens. BF T05129; ZER6 p52; Species: human, Homo sapiens. BF T05130; ZER6 p71; Species: human, Homo sapiens. BF T03914; ZF1; Species: pea, Pisum sativum. BF T02349; ZF5; Species: mouse, Mus musculus. BF T00921; Zfp-35; Species: mouse, Mus musculus. BF T04977; ZFP-37; Species: human, Homo sapiens. BF T03962; ZFP1; Species: thale cress, Arabidopsis thaliana. BF T03963; ZFP2; Species: thale cress, Arabidopsis thaliana. BF T03964; ZFP3; Species: thale cress, Arabidopsis thaliana. BF T03965; ZFP4; Species: thale cress, Arabidopsis thaliana. BF T03966; ZFP5; Species: thale cress, Arabidopsis thaliana. BF T03967; ZFP6; Species: thale cress, Arabidopsis thaliana. BF T03968; ZFP7; Species: thale cress, Arabidopsis thaliana. BF T03969; ZFP8; Species: thale cress, Arabidopsis thaliana. BF T02367; ZFX; Species: human, Homo sapiens. BF T04669; Zic1; Species: mouse, Mus musculus. BF T04237; ZIC2; Species: human, Homo sapiens. BF T04670; Zic2; Species: mouse, Mus musculus. BF T04671; Zic3; Species: mouse, Mus musculus. BF T01468; ZID; Species: human, Homo sapiens. BF T04595; ZMS1; Species: yeast, Saccharomyces cerevisiae. BF T02317; Zn-15; Species: rat, Rattus rattus. BF T04982; ZNF-20; Species: human, Homo sapiens. BF T04981; ZNF-24; Species: human, Homo sapiens. BF T04980; ZNF11a; Species: human, Homo sapiens. BF T04991; ZNF124; Species: human, Homo sapiens. BF T04992; ZNF133; Species: human, Homo sapiens. BF T04993; ZNF143; Species: human, Homo sapiens. BF T02279; ZNF174; Species: human, Homo sapiens. BF T04984; ZNF33a; Species: human, Homo sapiens. BF T04985; ZNF35; Species: human, Homo sapiens. BF T04986; ZNF43; Species: human, Homo sapiens. BF T04987; ZNF44; Species: human, Homo sapiens. BF T04988; ZNF45; Species: human, Homo sapiens. BF T04979; ZNF7; Species: human, Homo sapiens. BF T04994; ZNF76; Species: human, Homo sapiens. BF T04989; ZNF83; Species: human, Homo sapiens. BF T04990; ZNF85; Species: human, Homo sapiens. BF T02325; ZPT2-1; Species: Petunia hybrida. BF T03947; ZPT2-10; Species: Petunia hybrida. BF T03948; ZPT2-11; Species: Petunia hybrida. BF T03949; ZPT2-12; Species: Petunia hybrida. BF T03950; ZPT2-13; Species: Petunia hybrida. BF T03951; ZPT2-14; Species: Petunia hybrida. BF T02447; ZPT2-2; Species: Petunia hybrida. BF T02449; ZPT2-3; Species: Petunia hybrida. BF T03937; ZPT2-5; Species: Petunia hybrida. BF T03943; ZPT2-6; Species: Petunia hybrida. BF T03944; ZPT2-7; Species: Petunia hybrida. BF T03945; ZPT2-8; Species: Petunia hybrida. BF T03946; ZPT2-9; Species: Petunia hybrida. BF T03952; ZPT3-1; Species: Petunia hybrida. BF T03953; ZPT3-2; Species: Petunia hybrida. BF T03954; ZPT3-3; Species: Petunia hybrida. BF T03955; ZPT4-1; Species: Petunia hybrida. BF T03956; ZPT4-2; Species: Petunia hybrida. BF T03957; ZPT4-3; Species: Petunia hybrida. BF T03958; ZPT4-4; Species: Petunia hybrida. XX DR Prosite: PS00028. XX RN [1] RX MEDLINE; 91369958. RA Kochoyan M. Keutmann H. T. Weiss M. RT Alternating zinc finger motifs in the human male-associated protein ZFY: RT HX3H and HX4H motifs encode a local structure switch RL Biochemistry 30:9396-9402 (1991). RN [2] RX MEDLINE; 91308086. RA Kochoyan M. Keutmann H. T. Weiss M. RT Alternating zinc finger motifs in the human male-associated protein ZFY: RT Refinement of the NMR structure of an even finger by selecetive deuterium RT labeling and implications for DNA recognition RL Biochemistry 30:7063-7072 (1991). RN [3] RX MEDLINE; 92020871. RA Kochoyan M. Keutmann H. T. Weiss M. RT Architectural rules of the zinc-finger motif: comparative two-dimensional RT NMR studies of native and aromatic-swap domains define a weakly polar switch RL Proc. Natl. Acad. Sci. USA 88:8455-8459 (1991). RN [4] RX MEDLINE; 91227904. RA Pavletich N. P. Pablo C. O. RT Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at RT 2.1 A RL Science 252:809-816 (1991). RN [5] RX MEDLINE; 91064333. RA Omichinski J. G. Clore G. M. Appella E. Sakaguchi K. Gronenborn A. M. RT High-resolution three-dimensional structure of a single zinc finger from a RT human enhancer binding protein in solution RL Biochemistry 29:9324-9334 (1990). RN [6] RX MEDLINE; 90201076. RA Carr M. D. Pastore A. Gausepohl H. Frank R. Roesch P. RT NMR and molecular dynamics studies of the mKr2 'zinc finger' RL Eur. J. Biochem. 188:455-461 (1990). RN [7] RX MEDLINE; 90115825. RA Parraga G. Horvath S. Hood L. Young E. T. Klevit R. E. RT Spectroscopic studies of wild-type and mutant zinc finger peptides: RT Determinants of domain folding and structure RL Proc. Natl. Acad. Sci. USA 87:137-141 (1990). RN [8] RX MEDLINE; 89346749. RA Lee M. S. Gippert G. P. Soman K. V. Case D. A. Wright P. A. RT Three-dimensional solution structure of a single zinc finger DNA-binding RT domain RL Science 245:635-637 (1989). RN [9] RX MEDLINE; 88124828. RA Berg J. M. RT Proposed structure for the zinc-binding domains from transcription factor RT IIIA and related proteins RL Proc. Natl. Acad. Sci. USA 86:99-103 (1988). RN [10] RX MEDLINE; 88336881. RA Parraga G. Horvath S. J. Eisen A. Taylor W. E. Hood L. Young E. T. Klevit RA R. E. RT Zinc-dependent structure of a single-finger domain of yeast ADR1 RL Science 241:1489-1492 (1988). RN [11] RX MEDLINE; 87260885. RA Frankel A. D. Berg J. M. Pabo C. O. RT Metal-dependent folding of a single zinc finger from transcription factor RT IIIA RL Proc. Natl. Acad. Sci. USA 84:4841-4845 (1987). RN [12] RX MEDLINE; 87090387. RA Diakun G. P. Fairall L. Klug A. RT EXAFS study of the zinc-binding sites in the protein transcription factor RT IIIA RL Nature 324:698-699 (1986). RN [13] RX MEDLINE; 85284956. RA Miller J. McLachlan A. D. Klug A. RT Repetitive zinc-binding domains in the protein transcription factor IIIA RT from Xenopus oocytes RL EMBO J. 4:1609-1614 (1985). RN [14] RX MEDLINE; 85231235. RA Brown R. S. Sander C. Argos P. RT The primary structure of transcription factor TFIIIA has 12 consecutive RT repeats RL FEBS Lett. 186:271-274 (1985). RN [15] RA Boehm S. Drescher B. RT Multiple internal repeats within the structure of the 5S RNA/DNA binding RT transcription factor TF-IIIA from Xenopus laevis RL studia biophysica 107:237-247 (1985). RN [16] RX MEDLINE; 84061844. RA Hanas J. S. Hazuda D. J. Bogenhagen D. F. Wu F. Y.-H. Wu C.-W. RT Xenopus transcription factor A requires zinc for binding to the 5 S RNA gene RL J. Biol. Chem. 258:14120-14125 (1983). XX // AC C0002 XX ID CC (rec) XX DT 25.09.1993 (created); ewi. DT 02.03.1995 (updated); dbo. CO Copyright (C), Biobase GmbH. XX CL zinc finger; zinc twist XX CC Zinc finger motif of nuclear receptor type. Two such motifs differing in CC size, composition and function are present in each receptor molecule. Each CC finger comprises 4 cysteine residues coordinating one zinc ion. The second CC half including the second cysteine pair has alpha-helix conformation, the CC helix of the first finger binds to the DNA through the major groove. The CC sequence between the first two cysteines of the second finger mediates CC dimerization upon DNA-binding XX BF T00040; AR; Species: human, Homo sapiens. BF T00041; AR; Species: mouse, Mus musculus. BF T00042; AR; Species: rat, Rattus norvegicus. BF T04652; AR; Species: baboon, papio hamadryas. BF T04653; AR; Species: Chimpanzee, Pan troglodytes. BF T04654; AR; Species: macaque, macaca fascicularis. BF T04655; AR; Species: lemur, eulemur fulvus collaris. BF T00045; ARP-1; Species: human, Homo sapiens. BF T04659; BXR-beta; Species: rabbit, Oryctolagus cuniculus. BF T02261; CAR; Species: human, Homo sapiens. BF T00117; CF1; Species: fruit fly, Drosophila melanogaster. BF T00147; COUP; Species: rat, Rattus norvegicus. BF T00148; COUP; Species: chick, Gallus gallus. BF T02761; COUP; Species: clawed frog, Xenopus laevis. BF T00994; COUP-TF; Species: mouse, Mus musculus. BF T00149; COUP-TF1; Species: human, Homo sapiens. BF T04857; CXR; Species: chick, Gallus gallus. BF T02776; DAX1; Species: human, Homo sapiens. BF T04676; DAX1; Species: rat, Rattus norvegicus. BF T04677; DAX1; Species: mouse, Mus musculus. BF T04678; DAX1; Species: Pig, Sus scrofa. BF T01367; E75A; Species: fruit fly, Drosophila melanogaster. BF T01368; E75B; Species: fruit fly, Drosophila melanogaster. BF T02763; EAR2; Species: human, Homo sapiens. BF T00217; EcR; Species: fruit fly, Drosophila melanogaster. BF T00251; ELP; Species: mouse, Mus musculus. BF T00258; ER-alpha; Species: rat, Rattus norvegicus. BF T00259; ER-alpha; Species: mouse, Mus musculus. BF T00261; ER-alpha; Species: human, Homo sapiens. BF T00262; ER-alpha; Species: cattle, Bos taurus. BF T00263; ER-alpha; Species: clawed frog, Xenopus laevis. BF T00264; ER-alpha; Species: chick, Gallus gallus. BF T04651; ER-beta; Species: human, Homo sapiens. BF T04649; ER-beta1; Species: mouse, Mus musculus. BF T02765; ERR1; Species: human, Homo sapiens. BF T04849; ERR1; Species: mouse, Mus musculus. BF T02766; ERR2; Species: human, Homo sapiens. BF T04644; ERR3; Species: mouse, Mus musculus. BF T04645; ERR3; Species: human, Homo sapiens. BF T04647; ERR3-1; Species: mouse, Mus musculus. BF T04648; ERR3-1; Species: human, Homo sapiens. BF T02770; FTF; Species: human, Homo sapiens. BF T04754; FTF; Species: mouse, Mus musculus. BF T04755; FTF; Species: chick, Gallus gallus. BF T00296; FTZ-F1; Species: fruit fly, Drosophila melanogaster. BF T02753; FXR; Species: mouse, Mus musculus. BF T04494; FXR; Species: rat, Rattus norvegicus. BF T04498; FXR; Species: human, Homo sapiens. BF T02772; GCNF; Species: mouse, Mus musculus. BF T04401; GCNF-1; Species: human, Homo sapiens. BF T04400; GCNF-2; Species: human, Homo sapiens. BF T00333; GR; Species: rat, Rattus norvegicus. BF T00334; GR; Species: chick, Gallus gallus. BF T00335; GR; Species: mouse, Mus musculus. BF T00336; GR; Species: cat, Felis catus. BF T04685; GR; Species: clawed frog, Xenopus laevis. BF T05075; GR; Species: sheep, Ovis aries. BF T05076; GR; Species: human, Homo sapiens. BF T00337; GR alpha; Species: human, Homo sapiens. BF T01920; GR beta; Species: human, Homo sapiens. BF T04739; HMR; Species: dog, Canis familiaris. BF T02758; HNF-4; Species: human, Homo sapiens. BF T05017; HNF-4; Species: rat, Rattus norvegicus. BF T02739; HNF-4(D); Species: fruit fly, Drosophila melanogaster. BF T03828; HNF-4alpha; Species: human, Homo sapiens. BF T00372; HNF-4alpha1; Species: rat, Rattus norvegicus. BF T02421; HNF-4alpha1; Species: human, Homo sapiens. BF T02424; HNF-4alpha1; Species: mouse, Mus musculus. BF T02429; HNF-4alpha1; Species: clawed frog, Xenopus laevis. BF T00373; HNF-4alpha2; Species: human, Homo sapiens. BF T02422; HNF-4alpha2; Species: rat, Rattus norvegicus. BF T02423; HNF-4alpha2; Species: mouse, Mus musculus. BF T02428; HNF-4alpha3; Species: human, Homo sapiens. BF T02425; HNF-4alpha4; Species: human, Homo sapiens. BF T02427; HNF-4alpha7; Species: mouse, Mus musculus. BF T02432; HNF-4beta; Species: clawed frog, Xenopus laevis. BF T02430; HNF-4gamma; Species: human, Homo sapiens. BF T00445; KNIRPS; Species: fruit fly, Drosophila melanogaster. BF T04899; KNIRPS; Species: fruit fly, Drosophila virilis. BF T02752; LXR-alpha; Species: human, Homo sapiens. BF T04430; LXR-alpha; Species: mouse, Mus musculus. BF T04434; LXR-alpha; Species: rat, Rattus norvegicus. BF T04451; LXR-beta; Species: rat, Rattus norvegicus. BF T04453; LXR-beta; Species: human, Homo sapiens. BF T04467; LXR-beta; Species: mouse, Mus musculus. BF T00511; MR; Species: rat, Rattus norvegicus. BF T00513; MR; Species: human, Homo sapiens. BF T00619; NGFI-B; Species: rat, Rattus norvegicus. BF T04750; NOR1; Species: human, Homo sapiens. BF T04753; NOR1/MINOR; Species: human, Homo sapiens. BF T04752; NOR2; Species: rat, Rattus norvegicus. BF T01348; Nur77; Species: mouse, Mus musculus. BF T02742; NURR1; Species: human, Homo sapiens. BF T04312; NURR1; Species: mouse, Mus musculus. BF T04743; NURR1; Species: rat, Rattus norvegicus. BF T04744; NURR1; Species: clawed frog, Xenopus laevis. BF T03723; PNR; Species: human, Homo sapiens. BF T04861; PNR; Species: mouse, Mus musculus. BF T00694; PPAR-alpha; Species: mouse, Mus musculus. BF T00991; PPAR-alpha; Species: rat, Rattus norvegicus. BF T01352; PPAR-alpha; Species: clawed frog, Xenopus laevis. BF T02726; PPAR-alpha; Species: human, Homo sapiens. BF T01353; PPAR-beta; Species: clawed frog, Xenopus laevis. BF T02745; PPAR-beta; Species: human, Homo sapiens. BF T04781; PPAR-beta; Species: mouse, Mus musculus. BF T01354; PPAR-gamma; Species: clawed frog, Xenopus laevis. BF T02529; PPAR-gamma; Species: mouse, Mus musculus. BF T02736; PPAR-gamma1; Species: human, Homo sapiens. BF T04794; PPAR-gamma1; Species: cattle, Bos taurus. BF T03731; PPAR-gamma2; Species: human, Homo sapiens. BF T04780; PPAR-gamma2; Species: cattle, Bos taurus. BF T00696; PR; Species: human, Homo sapiens. BF T04680; PR; Species: mouse, Mus musculus. BF T04681; PR; Species: rat, Rattus norvegicus. BF T01660; PR A; Species: chick, Gallus gallus. BF T01661; PR A; Species: human, Homo sapiens. BF T00697; PR B; Species: rabbit, Oryctolagus cuniculus. BF T00698; PR B; Species: chick, Gallus gallus. BF T04630; PXR; Species: rabbit, Oryctolagus cuniculus. BF T04617; PXR-1; Species: human, Homo sapiens. BF T04618; PXR-1; Species: mouse, Mus musculus. BF T04629; PXR-1; Species: rat, Rattus norvegicus. BF T04619; PXR-2; Species: mouse, Mus musculus. BF T04641; PXR-2; Species: human, Homo sapiens. BF T00716; RAR; Species: monkey, Cercopithecus aethiops. BF T00717; RAR; Species: mouse, Mus musculus. BF T01327; RAR-alpha; Species: mouse, Mus musculus. BF T01356; RAR-alpha; Species: clawed frog, Xenopus laevis. BF T00719; RAR-alpha1; Species: human, Homo sapiens. BF T01335; RAR-alpha1; Species: mouse, Mus musculus. BF T01336; RAR-alpha2; Species: mouse, Mus musculus. BF T00721; RAR-beta; Species: human, Homo sapiens. BF T01328; RAR-beta; Species: mouse, Mus musculus. BF T01337; RAR-beta1; Species: mouse, Mus musculus. BF T01326; RAR-beta2; Species: human, Homo sapiens. BF T01338; RAR-beta2; Species: mouse, Mus musculus. BF T01339; RAR-beta3; Species: mouse, Mus musculus. BF T00720; RAR-gamma; Species: human, Homo sapiens. BF T01329; RAR-gamma; Species: mouse, Mus musculus. BF T04895; RAR-gamma; Species: zebra fish, Brachydanio rerio. BF T01330; RAR-gamma1; Species: human, Homo sapiens. BF T01340; RAR-gamma1; Species: mouse, Mus musculus. BF T01357; RAR-gamma1; Species: clawed frog, Xenopus laevis. BF T01341; RAR-gamma2; Species: mouse, Mus musculus. BF T01358; RAR-gamma2; Species: clawed frog, Xenopus laevis. BF T01344; REVERB-alpha; Species: rat, Rattus norvegicus. BF T02746; REVERB-alpha; Species: human, Homo sapiens. BF T02747; REVERB-beta; Species: human, Homo sapiens. BF T04896; REVERB-beta; Species: mouse, Mus musculus. BF T01527; RORalpha1; Species: human, Homo sapiens. BF T01528; RORalpha2; Species: human, Homo sapiens. BF T01529; RORalpha3; Species: human, Homo sapiens. BF T02748; RORbeta; Species: human, Homo sapiens. BF T02749; RORgamma; Species: human, Homo sapiens. BF T01331; RXR-alpha; Species: mouse, Mus musculus. BF T01345; RXR-alpha; Species: human, Homo sapiens. BF T01359; RXR-alpha; Species: clawed frog, Xenopus laevis. BF T04383; RXR-alpha; Species: rat, Rattus norvegicus. BF T01332; RXR-beta; Species: mouse, Mus musculus. BF T01334; RXR-beta; Species: human, Homo sapiens. BF T01349; RXR-beta; Species: rat, Rattus norvegicus. BF T02779; RXR-beta1; Species: mouse, Mus musculus. BF T01366; RXR-beta2; Species: mouse, Mus musculus. BF T01333; RXR-gamma; Species: mouse, Mus musculus. BF T01360; RXR-gamma; Species: clawed frog, Xenopus laevis. BF T04807; RXR-gamma; Species: human, Homo sapiens. BF T04845; RXR-gamma; Species: rat, Rattus norvegicus. BF T04859; RXR-gamma; Species: chick, Gallus gallus. BF T01147; SF-1; Species: mouse, Mus musculus. BF T02769; SF-1; Species: human, Homo sapiens. BF T04002; SF-1; Species: rat, Rattus norvegicus. BF T04014; SF-1; Species: cattle, Bos taurus. BF T04015; SF-1; Species: domestic pig, Sus scrofa. BF T04016; SF-1; Species: chick, Gallus gallus. BF T04017; SF-1; Species: medaka, Oryzias latipes. BF T04018; SF-1; Species: frog, Rana rugosa. BF T04065; SF-1; Species: zebra fish, Brachydanio rerio. BF T04069; SF-1; Species: turtle, Trachemys scripta. BF T02738; SHP; Species: human, Homo sapiens. BF T04610; SXR; Species: human, Homo sapiens. BF T00836; T3R; Species: mouse, Mus musculus. BF T00839; T3R; Species: rat, Rattus norvegicus. BF T00840; T3R; Species: rat, Rattus norvegicus. BF T00854; T3R; Species: monkey, Cercopithecus aethiops. BF T00838; T3R-alpha; Species: human, Homo sapiens. BF T00841; T3R-alpha; Species: rat, Rattus norvegicus. BF T01173; T3R-alpha; Species: mouse, Mus musculus. BF T01351; T3R-alpha; Species: chick, Gallus gallus. BF T04771; T3R-alpha; Species: Pig, Sus scrofa. BF T04774; T3R-alpha; Species: halibut, hippoglossus hippoglossus. BF T04810; T3R-alpha/RXR-alpha; Species: human, Homo sapiens. BF T01152; T3R-alpha1; Species: human, Homo sapiens. BF T01342; T3R-alpha1; Species: rat, Rattus norvegicus. BF T04720; T3R-alpha1; Species: clawed frog, Xenopus laevis. BF T01153; T3R-alpha2; Species: human, Homo sapiens. BF T01343; T3R-alpha2; Species: rat, Rattus norvegicus. BF T04721; T3R-alpha2; Species: clawed frog, Xenopus laevis. BF T00852; T3R-beta; Species: rat, Rattus norvegicus. BF T00851; T3R-beta1; Species: human, Homo sapiens. BF T00853; T3R-beta1; Species: rat, Rattus norvegicus. BF T01692; T3R-beta1; Species: chick, Gallus gallus. BF T04722; T3R-beta1; Species: mouse, Mus musculus. BF T01350; T3R-beta2; Species: rat, Rattus norvegicus. BF T01693; T3R-beta2; Species: chick, Gallus gallus. BF T04450; T3R-beta2; Species: human, Homo sapiens. BF T04723; T3R-beta2; Species: mouse, Mus musculus. BF T00789; Tll; Species: fruit fly, Drosophila melanogaster. BF T02357; TLX; Species: mouse, Mus musculus. BF T02376; TLX; Species: chick, Gallus domesticus. BF T04808; TLX; Species: human, Homo sapiens. BF T04894; TR-beta; Species: zebra fish, Brachydanio rerio. BF T01662; TR2; Species: human, Homo sapiens. BF T01664; TR2-11; Species: human, Homo sapiens. BF T04847; TR2-11; Species: mouse, Mus musculus. BF T01663; TR2-9; Species: human, Homo sapiens. BF T02767; TR3; Species: human, Homo sapiens. BF T02740; TR4; Species: human, Homo sapiens. BF T00886; v-ErbA; Species: AEV, avian erythroblastosis virus. BF T00882; VDR; Species: rat, Rattus norvegicus. BF T00883; VDR; Species: mouse, Mus musculus. BF T00884; VDR; Species: chick, Gallus gallus. BF T00885; VDR; Species: human, Homo sapiens. BF T01369; VDR; Species: domestic pig, Sus scrofa. XX DR Prosite: PS00031. XX RN [1] RX MEDLINE; 91326070. RA Luisi B. F. Xu W. X. Otwinowski Z. Freedman L. P. Yamamoto K. R. Sigler P. RA B. RT Crystallographic analysis of the interaction of the glucocorticoid receptor RT with DNA RL Nature 352:497-505 (1991). RN [2] RX MEDLINE; 91061891. RA Schwabe J. W. R. Neuhaus D. Rhodes D. RT Solution structure of the DNA-binding domain of the oestrogen receptor RL Nature 348:458-461 (1990). RN [3] RX MEDLINE; 91017545. RA Archer T. K. Hager G. L. Omichinski J. G. RT Sequence-specific DNA binding by glucocorticoid receptor zinc finger RT peptides RL Proc. Natl. Acad. Sci. USA 87:7560-7564 (1990). RN [4] RX MEDLINE; 90319784. RA Haerd T. Kelenbach E. Boelens R. Maler B. A. Dahlmann K. Freedman L. P. RA Carlstedt-Duke J. Yamamoto K. R. Gustafsson J.-A. Kaptein R. RT Solution structure of the glucocorticoid receptor DNA-binding domain RL Science 249:157-160 (1990). RN [5] RX MEDLINE; 89030597. RA Green S. Kumar V. Theulaz I. Wahli W. Chambon P. RT The N-terminal DNA-binding 'zinc-finger' of the oestrogen and RT glucocorticoid receptors determines target gene specificity RL EMBO J. 7:3037-3044 (1988). RN [6] RX MEDLINE; 89052664. RA Severne Y. Wieland S. Schaffner W. Rusconi S. RT Metal binding 'finger' structures in the glucocorticoid receptor defined by RT site-dierected mutagenesis RL EMBO J. 7:2503-2508 (1988). RN [7] RX MEDLINE; 87250479. RA Sabbah M. Redeuilh G. Secco C. Baulieu E.-E. RT The binding activity of estrogen receptor to DNA and heat shock protein (Mr RT 90,000) is dependent on receptor-bound metal RL J. Biol. Chem. 262:8631-8635 (1987). XX // AC C0003 XX ID CC (g) XX DT 25.09.1993 (created); ewi. DT 18.05.1999 (updated); vma. CO Copyright (C), Biobase GmbH. XX CL zinc finger XX CC Zinc finger motif of GATA-type. Can be subclassified into two sub-types, CC one of which is found in animal factors, the other one in plant factors. In CC fungi factors from both groups have been found. Most known animal GATA CC factors contain two zinc finger domains; most known fungal, plant and CC slimemold GATA factors only one [1]. In case of the two-fingered factors, CC as far as it has been investigated, only the C-terminal zinc finger plus an CC adjacent basic region are essential and sufficient for DNA-binding [4] [3] CC [5]. Each finger comprises 4 cysteine residues coordinating one zinc ion. CC The DNA-binding zinc finger is composed of two irregular antiparallel CC beta-sheets and an alpha-helix; similar in structure, although not in CC sequence to the zinc finger of the glucocorticoid receptor DNA binding CC domain. The alpha-helix and the loop connecting the two antiparallel CC beta-sheets interact with the major groove of the DNA. The basic region CC carboxyl-terminal to the zinc finger wraps around into the minor groove [2]. XX BF T02533; AREA; Species: Aspergillus nidulans, Emericella nidulans. BF T03916; CO (a1); Species: rape, Brassica napus. BF T03917; CO (a9); Species: rape, Brassica napus. BF T03919; CO (b1); Species: rape, Brassica napus. BF T02816; CONSTANS; Species: thale cress, Arabidopsis thaliana. BF T02411; DAL80; Species: yeast, Saccharomyces cerevisiae. BF T03691; elt-1; Species: Caenorhabditis elegans. BF T01690; elt-2; Species: Caenorhabditis elegans. BF T02831; gaf1; Species: fission yeast, Schizosaccharomyces pombe. BF T02825; gaf2; Species: fission yeast, Schizosaccharomyces pombe. BF T02817; GAT1; Species: yeast, Saccharomyces cerevisiae. BF T03314; GAT2; Species: yeast, Saccharomyces cerevisiae. BF T03315; GAT3; Species: yeast, Saccharomyces cerevisiae. BF T03316; GAT4; Species: yeast, Saccharomyces cerevisiae. BF T00267; GATA-1; Species: chick, Gallus gallus. BF T00305; GATA-1; Species: mouse, Mus musculus. BF T00306; GATA-1; Species: human, Homo sapiens. BF T00304; GATA-1A; Species: clawed frog, Xenopus laevis. BF T02312; GATA-1B; Species: clawed frog, Xenopus laevis. BF T00307; GATA-2; Species: chick, Gallus gallus. BF T00308; GATA-2; Species: human, Homo sapiens. BF T00309; GATA-2; Species: clawed frog, Xenopus laevis. BF T00310; GATA-3; Species: mouse, Mus musculus. BF T00311; GATA-3; Species: human, Homo sapiens. BF T00312; GATA-3; Species: clawed frog, Xenopus laevis. BF T00313; GATA-3; Species: cat, Felis catus. BF T00314; GATA-3; Species: chick, Gallus gallus. BF T02532; GATA-4; Species: mouse, Mus musculus. BF T02682; GATA-4; Species: chick, Gallus gallus. BF T02687; GATA-4; Species: human, Homo sapiens. BF T02711; GATA-4; Species: clawed frog, Xenopus laevis. BF T02716; GATA-4; Species: rat, Rattus norvegicus. BF T02683; GATA-5; Species: chick, Gallus gallus. BF T02685; GATA-5; Species: mouse, Mus musculus. BF T02688; GATA-5; Species: human, Homo sapiens. BF T02712; GATA-5A; Species: clawed frog, Xenopus laevis. BF T02713; GATA-5B; Species: clawed frog, Xenopus laevis. BF T02684; GATA-6; Species: chick, Gallus gallus. BF T02686; GATA-6; Species: mouse, Mus musculus. BF T02689; GATA-6; Species: human, Homo sapiens. BF T02717; GATA-6; Species: rat, Rattus norvegicus. BF T02714; GATA-6A; Species: clawed frog, Xenopus laevis. BF T02715; GATA-6B; Species: clawed frog, Xenopus laevis. BF T02818; GLN3; Species: yeast, Saccharomyces cerevisiae. BF T02827; GZF3; Species: yeast, Saccharomyces cerevisiae. BF T00567; NF-E1b; Species: chick, Gallus gallus. BF T00627; NIT2; Species: Neurospora crassa. BF T02828; NRFA; Species: Penicillium urticae. BF T02835; NSDD; Species: Aspergillus nidulans, Emericella nidulans. BF T03977; NTL1; Species: tobacco, Nicotiana tabacum. BF T02829; NUT1; Species: Magnaporthe grisea. BF T02833; PBP; Species: Fusarium solani. BF T02837; SRD1; Species: yeast, Saccharomyces cerevisiae. BF T02823; SREP; Species: Penicillium chrysogenum. BF T02836; STKA; Species: slime mould, Dictyostelium discoideum. BF T03972; STO; Species: thale cress, Arabidopsis thaliana. BF T02406; URBS1; Species: Ustilago maydis. BF T02819; WC1; Species: Neurospora crassa. BF T02834; WC2; Species: Neurospora crassa. XX DR Prosite: PS00344. XX RN [1] RX MEDLINE; 98242602. RA Teakle G. R. Gilmartin P. M. RT Two forms of type IV zinc-finger motif and their kingdom-specific RT distribution between the flora, fauna and fungi. RL Trends Biochem. Sci. 23:100-102 (1998). RN [2] RX MEDLINE; 93324913. RA Omichinski J. G. Clore G. M. Schaad O. Felsenfeld G. Trainor C. Appella E. RA Stahl S. J. Gronenborn A. M. RT NMR structure of a specific DNA complex of Zn-containing DNA binding domain RT of GATA-1. RL Science 261:438-446 (1993). RN [3] RX MEDLINE; 93189561. RA Omichinski J. G. Trainor C. Evans T. Gronenborn A. M. Clore G. M. RA Felsenfeld G. RT A small single-"finger" peptide from the erythroid transcription factor RT GATA-1 binds specifically to DNA as a zinc or iron complex. RL Proc. Natl. Acad. Sci. USA 90:1676-1680 (1993). RN [4] RX MEDLINE; 93024401. RA Yang H.-Y. Evans T. RT Distinct roles for the two cGATA-1 finger domains RL Mol. Cell. Biol. 12:4562-4570 (1992). RN [5] RX MEDLINE; 91115078. RA Martin D. I. K. Orkin St. H. RT Transcriptional activation and DNA binding by the erythroid factor RT GF-1/NF-E1/Eryf 1 RL Genes Dev. 4:1886-1898 (1990). RN [6] RX MEDLINE; 90114418. RA Trainor C. D. Evans T. Felsenfeld G. Boguski M. S. RT Structure and evolution of a human erythroid transcription factor RL Nature 343:92-96 (1990). RN [7] RX MEDLINE; 89376538. RA Evans T. Felsenfeld G. RT The erythroid-specific transcription factor Eryf1: A new finger protein RL Cell 58:877-885 (1989). RN [8] RX MEDLINE; 89181931. RA Martin D. I. K. Tsai S.-F. Orkin S. H. RT Increased gamma-globin expression in a nondeletion HPFH mediated by an RT erythroid-specific DNA-binding factor RL Nature 338:435-438 (1989). RN [9] RX MEDLINE; 89262083. RA Tsai S.-F. Martin D. I. K. Zon L. I. D'Andrea A. D. Wong G. G. Orkin S. H. RT Cloning of cDNA for the major DNA-binding protein of the erythroid lineage RT through expression in mammalian cells RL Nature 339:446-451 (1989). XX // AC C0004 XX ID CC XX DT 25.09.1993 (created); ewi. CO Copyright (C), Biobase GmbH. XX CL zinc finger XX CC Zinc finger motif of C4 type. Each finger comprises 4 cysteine residues CC presumably coordinating one zinc ion. XX BF T00209; E1A 13S protein; Species: adenovirus type 2. BF T00315; GBF; Species: slime mould, Dictyostelium discoideum. BF T00709; qa-1F; Species: Neurospora crassa. BF T03591; SIG1; Species: yeast, Saccharomyces cerevisiae. BF T00850; Ttx; Species: fruit fly, Drosophila melanogaster. BF T02347; YAF2; Species: human, Homo sapiens. XX // AC C0005 XX ID C6 XX DT 25.09.1993 (created); ewi. DT 05.04.2000 (updated); sth. CO Copyright (C), Biobase GmbH. XX CL zinc cluster; zinc-cysteine cluster; C6 zinc finger XX CC Zinc finger motif of GAL4-type. Present to date in many fungal regulators. CC The proteins are typically, though not exclusively transcriptional CC activators. Six cysteine residues coordinate two zinc ions, i. e. two of CC the thiol groups coordinate two zinc ions (six cysteines binuclear cluster CC DNA-binding domain). All GAL4-type proteins possess a single N-terminal CC zinc finger with an adjacent basic region, which is critical for CC sequence-specific recognition. Each C3-repeat unit of the structural motif CC of six cysteines forms short alpha-helical structures separated by a loop CC with a proline-associated turn. A number of zinc cluster proteins contain CC leucine zipper-like heptad repeat motifs C-terminal to the zinc-cluster. CC These motifs have been shown to form coiled-coil structures involved in CC protein-protein interactions (often homodimerization). The GAL-4 protein CC binds as a dimer to DNA sites charcterized by the presence of two CGG CC triplets separated by 11 base pairs. The zinc(II)-binding cluster lies in CC the DNA major groove and contacts three base pairs. XX BF T03237; AFLR; Species: Aspergillus flavus. BF T02814; AlcR; Species: Aspergillus nidulans, Emericella nidulans. BF T00931; AmdR; Species: Aspergillus nidulans, Emericella nidulans. BF T00044; ARG81; Species: yeast, Saccharomyces cerevisiae. BF T04566; ARO80; Species: yeast, Saccharomyces cerevisiae. BF T03227; CAT8; Species: yeast, Saccharomyces cerevisiae. BF T02848; CHA4; Species: yeast, Saccharomyces cerevisiae. BF T03234; CTF1alpha; Species: Fusarium solani. BF T03293; DAL81; Species: yeast, Saccharomyces cerevisiae. BF T03300; ECM22; Species: yeast, Saccharomyces cerevisiae. BF T02841; FACB; Species: Aspergillus nidulans, Emericella nidulans. BF T02843; FACB; Species: Aspergillus oryzae. BF T02892; FACB; Species: Aspergillus niger. BF T00302; GAL4; Species: yeast, Saccharomyces cerevisiae. BF T03425; HAL9; Species: yeast, Saccharomyces cerevisiae. BF T00346; HAP1; Species: yeast, Saccharomyces cerevisiae. BF T00458; LAC9; Species: yeast, Kluyveromyces lactis. BF T00465; LEU3; Species: yeast, Saccharomyces cerevisiae. BF T03472; LYS14; Species: yeast, Saccharomyces cerevisiae. BF T03473; MAL13; Species: yeast, Saccharomyces cerevisiae. BF T03475; MAL23; Species: yeast, Saccharomyces cerevisiae. BF T03476; MAL33; Species: yeast, Saccharomyces cerevisiae. BF T00480; MAL63; Species: yeast, Saccharomyces cerevisiae. BF T02844; NIRA; Species: Aspergillus nidulans, Emericella nidulans. BF T02845; NIT4; Species: Neurospora crassa. BF T02850; ntf1; Species: fission yeast, Schizosaccharomyces pombe. BF T03524; PDR1; Species: yeast, Saccharomyces cerevisiae. BF T03525; PDR3; Species: yeast, Saccharomyces cerevisiae. BF T03528; PIP2; Species: yeast, Saccharomyces cerevisiae. BF T00695; PPR1; Species: yeast, Saccharomyces cerevisiae. BF T01163; PUT3; Species: yeast, Saccharomyces cerevisiae. BF T02849; QUTA; Species: Aspergillus nidulans, Emericella nidulans. BF T04614; RDS2; Species: yeast, Saccharomyces cerevisiae. BF T03556; RGT1; Species: yeast, Saccharomyces cerevisiae. BF T04579; RSC3; Species: yeast, Saccharomyces cerevisiae. BF T03587; SEF1; Species: yeast, Saccharomyces cerevisiae. BF T04820; SHI; Species: thale cress, Arabidopsis thaliana. BF T03675; STB4; Species: yeast, Saccharomyces cerevisiae. BF T03676; STB5; Species: yeast, Saccharomyces cerevisiae. BF T04582; SUT1; Species: yeast, Saccharomyces cerevisiae. BF T01684; TEA1; Species: yeast, Saccharomyces cerevisiae. BF T03683; THI2; Species: yeast, Saccharomyces cerevisiae. BF T02846; UAY; Species: Aspergillus nidulans, Emericella nidulans. BF T03322; UGA3; Species: yeast, Saccharomyces cerevisiae. BF T01247; UME6; Species: yeast, Saccharomyces cerevisiae. BF T04612; UPC2; Species: yeast, Saccharomyces cerevisiae. BF T03708; YAF1; Species: yeast, Saccharomyces cerevisiae. BF T03716; YRR1; Species: yeast, Saccharomyces cerevisiae. XX DR Prosite: PS00463. XX RN [1] RX MEDLINE; 92212464. RA Baleja J. D. Marmorstein R. Harrison S. C. Wagner G. RT Solution structure of the DNA-binding domain of Cd2-GAL4 from S. cerevisiae RL Nature 356:450-453 (1992). RN [2] RX MEDLINE; 92212463. RA Kraulis P. J. Raine A. R. C. Gadhavi P. L. Laue E. D. RT Structure of the DNA-binding domain of zinc GAL4 RL Nature 356:448-450 (1992). RN [3] RX MEDLINE; 92212455. RA Marmorstein R. Carey M. Ptashne M. Harrison S. C. RT DNA recognition by GAL4: structure of a protein-DNA complex RL Nature 356:408-414 (1992). RN [4] RX MEDLINE; 91214955. RA Pan T. Coleman J. E. RT Sequential assignments of the 1H NMR resonances of Zn(II)2 and 113Cd(II)2 RT derivatives of the DNA-binding domain of the GAL4 transcription factor RT reveal a novel structural motif for specific DNA recognition RL Biochemistry 30:4212-4222 (1991). RN [5] RX MEDLINE; 92069011. RA Gardner K. H. Pan T. Narula S. Rivera E. Coleman J. E. RT Structure of the binuclear metal-binding site in the GAL4 transcription RT factor RL Biochemistry 30:11292-11302 (1991). RN [6] RX MEDLINE; 90192750. RA Pan T. Coleman J. E. RT GAL4 transcription factor is not a zinc finger but forms a Zn(II)2Cys6 RT binuclear cluster RL Proc. Natl. Acad. Sci. USA 87:2077-2081 (1990). RN [7] RX MEDLINE; 89240693. RA Pan T. Coleman J. E. RT Structure and function of the Zn(II) binding site within the DNA-binding RT domain of the GAL4 transcription factor RL Proc. Natl. Acad. Sci. USA 86:3145-3149 (1989). RN [8] RX MEDLINE; 87258276. RA Johnston M. RT Genetic evidence that zinc is an essential co-factor in the DNA binding RT domain of GAL4 protein RL Nature 328:353-355 (1987). XX // AC C0006 XX ID homeo XX DT 25.09.1993 (created); ewi. CO Copyright (C), Biobase GmbH. XX CL homeodomain; homeobox protein XX CC Three consecutive alpha-helix structures, helix 3 contacts mainly the major CC groove of the DNA, some contacts at the minor groove are observed as well. CC Helix 2 and 3 resemble the helix-turn-helix structure of prokaryotic CC regulators. XX BF T03429; A2; Species: yeast, Saccharomyces cerevisiae. BF T01992; Abd-A; Species: fruit fly, Drosophila melanogaster. BF T03827; Abd-A; Species: grasshopper, Schistocerca gregaria. BF T03835; Abd-A; Species: spider, Cupiennius salei. BF T03857; Abd-A; Species: firebrat, Thermobia domestica. BF T03849; Abd-AI; Species: red flour beetle, Tribolium castaneum. BF T03850; Abd-AII; Species: red flour beetle, Tribolium castaneum. BF T01476; Abd-B; Species: fruit fly, Drosophila melanogaster. BF T03826; Abd-B; Species: grasshopper, Schistocerca gregaria. BF T03834; Abd-B; Species: spider, Cupiennius salei. BF T03851; Abd-B; Species: red flour beetle, Tribolium castaneum. BF T03858; Abd-B; Species: firebrat, Thermobia domestica. BF T03343; Alx-3; Species: mouse, Mus musculus. BF T04262; Alx-3; Species: golden hamster, Mesocricetus auratus. BF T02967; Alx-4; Species: mouse, Mus musculus. BF T04012; Alx-4; Species: human, Homo sapiens. BF T04515; ALX3; Species: human, Homo sapiens. BF T03694; AmphiHox-1; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03703; AmphiHox-10; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03695; AmphiHox-2; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03696; AmphiHox-3; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03697; AmphiHox-4; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03698; AmphiHox-5; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03699; AmphiHox-6; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03700; AmphiHox-7; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03701; AmphiHox-8; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03702; AmphiHox-9; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T00026; Antp; Species: fruit fly, Drosophila melanogaster. BF T03839; Antp; Species: spider, Cupiennius salei. BF T03847; Antp; Species: red flour beetle, Tribolium castaneum. BF T03856; Antp; Species: firebrat, Thermobia domestica. BF T03873; Antp; Species: Lingula anatina. BF T01993; ARA; Species: fruit fly, Drosophila melanogaster. BF T03960; ARIX; Species: rat, Rattus norvegicus. BF T04112; ATH1; Species: thale cress, Arabidopsis thaliana. BF T02665; Bap; Species: fruit fly, Drosophila melanogaster. BF T03926; BarH1; Species: fruit fly, Drosophila melanogaster. BF T03927; BarH2; Species: fruit fly, Drosophila melanogaster. BF T03920; Barhl1; Species: mouse, Mus musculus. BF T03921; Barhl1; Species: human, Homo sapiens. BF T03923; Barhl2; Species: human, Homo sapiens. BF T02403; Barx1; Species: mouse, Mus musculus. BF T03918; Barx1; Species: human, Homo sapiens. BF T03934; Barx1; Species: chick, Gallus gallus. BF T03928; Barx2; Species: human, Homo sapiens. BF T03929; Barx2; Species: mouse, Mus musculus. BF T03931; Barx2; Species: sheep, Ovis aries. BF T03925; Barx2b; Species: chick, Gallus gallus. BF T04452; Barx2b; Species: mouse, Mus musculus. BF T00063; Bcd; Species: fruit fly, Drosophila melanogaster. BF T04113; BEL1; Species: thale cress, Arabidopsis thaliana. BF T04278; C36F7.1; Species: Caenorhabditis elegans. BF T00079; Cad; Species: fruit fly, Drosophila melanogaster. BF T03978; Cart-1; Species: human, Homo sapiens. BF T03980; Cart-1; Species: rat, Rattus norvegicus. BF T03981; Cart-1; Species: clawed frog, Xenopus laevis. BF T03999; Cart-1; Species: mouse, Mus musculus. BF T01994; CAUP; Species: fruit fly, Drosophila melanogaster. BF T02043; CDP2; Species: rat, Rattus norvegicus. BF T01484; Cdx-1; Species: chick, Gallus gallus. BF T01999; Cdx-1; Species: mouse, Mus musculus. BF T02000; Cdx-1; Species: rat, Rattus norvegicus. BF T02001; Cdx-1; Species: clawed frog, Xenopus laevis. BF T03248; Cdx-1; Species: human, Homo sapiens. BF T02002; Cdx-2; Species: mouse, Mus musculus. BF T02003; Cdx-3; Species: golden hamster, Mesocricetus auratus. BF T03245; Cdx-4; Species: mouse, Mus musculus. BF T03247; Cdx-4; Species: human, Homo sapiens. BF T03246; CDX2; Species: human, Homo sapiens. BF T02978; ceh-1; Species: Caenorhabditis elegans. BF T02980; ceh-10; Species: Caenorhabditis elegans. BF T02987; ceh-12; Species: Caenorhabditis vulgarensis. BF T02988; ceh-13; Species: Caenorhabditis elegans. BF T02996; ceh-14; Species: Caenorhabditis elegans. BF T03373; ceh-16; Species: Caenorhabditis elegans. BF T03355; ceh-19; Species: Caenorhabditis elegans. BF T02989; ceh-2; Species: Caenorhabditis elegans. BF T03356; ceh-20; Species: Caenorhabditis elegans. BF T03297; ceh-21; Species: Caenorhabditis elegans. BF T03357; ceh-22; Species: Caenorhabditis elegans. BF T03358; ceh-23; Species: Caenorhabditis elegans. BF T03374; ceh-24; Species: Caenorhabditis elegans. BF T03376; ceh-24; Species: Caenorhabditis briggsae. BF T03375; ceh-25; Species: Caenorhabditis elegans. BF T03367; ceh-26; Species: Caenorhabditis elegans. BF T02990; ceh-3 (pal-1); Species: Caenorhabditis elegans. BF T03359; ceh-30; Species: Caenorhabditis elegans. BF T03360; ceh-31; Species: Caenorhabditis elegans. BF T03361; ceh-32; Species: Caenorhabditis elegans. BF T03362; ceh-33; Species: Caenorhabditis elegans. BF T03363; ceh-34; Species: Caenorhabditis elegans. BF T03379; ceh-35; Species: Caenorhabditis elegans. BF T03364; ceh-36; Species: Caenorhabditis elegans. BF T03365; ceh-37; Species: Caenorhabditis elegans. BF T03298; ceh-39; Species: Caenorhabditis elegans. BF T03366; ceh-40; Species: Caenorhabditis elegans. BF T02992; ceh-5; Species: Caenorhabditis elegans. BF T02993; ceh-6; Species: Caenorhabditis elegans. BF T02994; ceh-7; Species: Caenorhabditis elegans. BF T02995; ceh-8; Species: Caenorhabditis elegans. BF T02979; ceh-9; Species: Caenorhabditis elegans. BF T02970; Chx10; Species: mouse, Mus musculus. BF T04139; Chx10; Species: human, Homo sapiens. BF T04142; Chx10; Species: chick, Gallus gallus. BF T04141; Chx10-1; Species: chick, Gallus gallus. BF T01485; Clox; Species: dog, Canis canis. BF T01995; Clox; Species: dog, Canis canis. BF T03733; Cnox-1; Species: Podocoryne carnea. BF T03734; Cnox-1; Species: Chlorohydra viridissima. BF T03742; Cnox-1; Species: Eleutheria dichotoma. BF T03746; Cnox-1; Species: hydra, Hydra vulgaris. BF T03735; Cnox-2; Species: Chlorohydra viridissima. BF T03743; Cnox-2; Species: Eleutheria dichotoma. BF T03745; Cnox-2; Species: hydra, Hydra vulgaris. BF T03736; Cnox-3; Species: Chlorohydra viridissima. BF T03739; Cnox-3; Species: Eleutheria dichotoma. BF T03744; Cnox-3; Species: hydra, Hydra vulgaris. BF T03737; Cnox-4; Species: Chlorohydra viridissima. BF T03740; Cnox-4; Species: Eleutheria dichotoma. BF T03741; Cnox-5; Species: Eleutheria dichotoma. BF T02792; Crx; Species: human, Homo sapiens. BF T03458; Crx; Species: rat, Rattus norvegicus. BF T03461; Crx; Species: mouse, Mus musculus. BF T03489; Crx; Species: cattle, Bos taurus. BF T03281; CUP9; Species: yeast, Saccharomyces cerevisiae. BF T02004; Cut; Species: fruit fly, Drosophila melanogaster. BF T00100; CUTL1; Species: human, Homo sapiens. BF T02042; Cutl1; Species: mouse, Mus musculus. BF T05024; Cutl1; Species: mink, Mustela vison. BF T04455; CUTL2; Species: human, Homo sapiens. BF T04456; Cutl2; Species: mouse, Mus musculus. BF T00193; Dfd; Species: fruit fly, Drosophila melanogaster. BF T03832; Dfd; Species: woodlouse, Porcellio scaber. BF T03840; Dfd; Species: spider, Cupiennius salei. BF T03845; Dfd; Species: red flour beetle, Tribolium castaneum. BF T03854; Dfd; Species: firebrat, Thermobia domestica. BF T03864; Dfd; Species: sandworm, Nereis virens. BF T02005; Dll; Species: fruit fly, Drosophila melanogaster. BF T02006; Dlx-1; Species: mouse, Mus musculus. BF T02007; Dlx-1; Species: clawed frog, Xenopus laevis. BF T02405; Dlx-1; Species: zebra fish, Brachydanio rerio. BF T03985; Dlx-1; Species: human, Homo sapiens. BF T02009; Dlx-2; Species: mouse, Mus musculus. BF T02407; Dlx-2; Species: human, Homo sapiens. BF T02408; Dlx-2; Species: zebra fish, Brachydanio rerio. BF T02409; Dlx-3; Species: mouse, Mus musculus. BF T02452; Dlx-3; Species: rat, Rattus norvegicus. BF T03991; Dlx-3; Species: human, Homo sapiens. BF T04003; Dlx-4 (long isoform); Species: human, Homo sapiens. BF T03992; Dlx-4 (short isoform); Species: human, Homo sapiens. BF T03986; Dlx-5; Species: human, Homo sapiens. BF T03989; Dlx-5; Species: mouse, Mus musculus. BF T03988; Dlx-6; Species: human, Homo sapiens. BF T03990; Dlx-6; Species: mouse, Mus musculus. BF T03993; Dlx-7; Species: mouse, Mus musculus. BF T04604; DOH1; Species: Dendrobium grex Madame Thong-In. BF T04013; DUX1; Species: human, Homo sapiens. BF T04137; DUX2; Species: human, Homo sapiens. BF T04136; DUX3; Species: human, Homo sapiens. BF T04138; DUX4; Species: human, Homo sapiens. BF T02981; egl-5; Species: Caenorhabditis elegans. BF T02008; Ems; Species: fruit fly, Drosophila melanogaster. BF T02010; Emx-1; Species: human, Homo sapiens. BF T02011; Emx-1; Species: mouse, Mus musculus. BF T02012; Emx-2; Species: human, Homo sapiens. BF T02013; Emx-2; Species: mouse, Mus musculus. BF T00253; En; Species: fruit fly, Drosophila melanogaster. BF T02014; En-1; Species: chick, Gallus gallus. BF T02015; En-1; Species: human, Homo sapiens. BF T02016; En-1; Species: mouse, Mus musculus. BF T02017; En-1; Species: clawed frog, Xenopus laevis. BF T03836; En-1; Species: spider, Cupiennius salei. BF T02018; En-2; Species: chick, Gallus gallus. BF T02019; En-2; Species: human, Homo sapiens. BF T02020; En-2; Species: mouse, Mus musculus. BF T04263; En-2; Species: golden hamster, Mesocricetus auratus. BF T03478; Esx-1a; Species: mouse, Mus musculus. BF T03474; Esx-1b; Species: mouse, Mus musculus. BF T04844; ESXR1; Species: human, Homo sapiens. BF T00271; Eve; Species: grasshopper, Schistocerca americana. BF T00272; Eve; Species: fruit fly, Drosophila melanogaster. BF T02021; EVX1; Species: human, Homo sapiens. BF T02023; Evx1; Species: mouse, Mus musculus. BF T02024; Evx1; Species: clawed frog, Xenopus laevis. BF T03669; Evx1; Species: zebra fish, Brachydanio rerio. BF T04488; Evx2; Species: Horn shark, Heterodontus francisci. BF T01482; Exd; Species: fruit fly, Drosophila melanogaster. BF T02044; Flh; Species: zebra fish, Brachydanio rerio. BF T02045; Flh; Species: clawed frog, Xenopus laevis. BF T00295; Ftz; Species: fruit fly, Drosophila melanogaster. BF T04023; Gbx1; Species: human, Homo sapiens. BF T04024; Gbx1; Species: mouse, Mus musculus. BF T04031; Gbx1; Species: chick, Gallus gallus. BF T04019; Gbx2; Species: human, Homo sapiens. BF T04020; Gbx2; Species: mouse, Mus musculus. BF T04021; Gbx2; Species: chick, Gallus gallus. BF T04022; Gbx2; Species: clawed frog, Xenopus laevis. BF T04030; Gbx2; Species: goldfish, Carassius auratus. BF T02046; Gsc; Species: chick, Gallus domesticus. BF T02047; Gsc; Species: mouse, Mus musculus. BF T04037; Gsc; Species: human, Homo sapiens. BF T04041; Gsc; Species: fruit fly, Drosophila melanogaster. BF T04051; Gsc; Species: zebra fish, Brachydanio rerio. BF T02048; Gsc A; Species: clawed frog, Xenopus laevis. BF T02049; Gsc B; Species: clawed frog, Xenopus laevis. BF T04038; Gscl; Species: human, Homo sapiens. BF T04039; Gscl; Species: mouse, Mus musculus. BF T05100; gsh-1; Species: mouse, Mus musculus. BF T04040; Gsx; Species: chick, Gallus gallus. BF T04457; HANF; Species: human, Homo sapiens. BF T03420; HB9; Species: human, Homo sapiens. BF T03421; HB9; Species: mouse, Mus musculus. BF T03436; HB9; Species: chick, Gallus gallus. BF T03766; HBox-1; Species: sea urchin, Heliocidaris erythrogramma. BF T03770; HBox-10; Species: sea urchin, Heliocidaris erythrogramma. BF T03771; HBox-11; Species: sea urchin, Paracentrotus lividus. BF T03767; HBox-6; Species: sea urchin, Heliocidaris erythrogramma. BF T03769; HBox-7; Species: sea urchin, Heliocidaris erythrogramma. BF T03768; HBox-9; Species: sea urchin, Heliocidaris erythrogramma. BF T04059; HD1; Species: rape, Brassica napus. BF T02091; Hex; Species: chick, Gallus gallus. BF T02092; Hex; Species: human, Homo sapiens. BF T03417; Hex; Species: mouse, Mus musculus. BF T03418; Hex; Species: clawed frog, Xenopus. BF T02051; HLX; Species: human, Homo sapiens. BF T02053; Hlx; Species: mouse, Mus musculus. BF T04443; HMX1; Species: human, Homo sapiens. BF T04444; Hmx1; Species: mouse, Mus musculus. BF T04445; Hmx2; Species: mouse, Mus musculus. BF T04446; Hmx3; Species: mouse, Mus musculus. BF T03296; HNF-6; Species: mouse, Mus musculus. BF T03257; HNF-6alpha; Species: rat, Rattus norvegicus. BF T03286; HNF-6alpha; Species: human, Homo sapiens. BF T03258; HNF-6beta; Species: rat, Rattus norvegicus. BF T03842; Hox-3; Species: spider, Cupiennius salei. BF T02054; HOX11; Species: human, Homo sapiens. BF T02055; Hox11; Species: mouse, Mus musculus. BF T03863; HOX3; Species: sandworm, Nereis virens. BF T03871; HOX3; Species: Lingula anatina. BF T01695; HOXA1; Species: human, Homo sapiens. BF T01696; HOXA1; Species: mouse, Mus musculus. BF T01697; HOXA1; Species: clawed frog, Xenopus laevis. BF T03709; HOXA1; Species: rat, Rattus norvegicus. BF T03710; HOXA1; Species: Horn shark, Heterodontus francisci. BF T03779; HOXA1; Species: Japanese pufferfish, Fugu rubripes. BF T01712; HOXA10; Species: chick, Gallus gallus. BF T01713; HOXA10; Species: human, Homo sapiens. BF T01715; HOXA10; Species: mouse, Mus musculus. BF T03778; HOXA10; Species: Japanese pufferfish, Fugu rubripes. BF T04480; HOXA10; Species: Horn shark, Heterodontus francisci. BF T01714; HOXA10 PL2; Species: human, Homo sapiens. BF T03625; HOXA10b; Species: zebra fish, Brachydanio rerio. BF T01716; HOXA11; Species: chick, Gallus gallus. BF T01717; HOXA11; Species: mouse, Mus musculus. BF T03320; HOXA11; Species: human, Homo sapiens. BF T03796; HOXA11; Species: Japanese pufferfish, Fugu rubripes. BF T03626; HOXA11a; Species: zebra fish, Brachydanio rerio. BF T03661; HOXA11b; Species: zebra fish, Brachydanio rerio. BF T03321; HOXA13; Species: human, Homo sapiens. BF T03337; HOXA13; Species: mouse, Mus musculus. BF T03628; HOXA13a; Species: zebra fish, Brachydanio rerio. BF T03627; HOXA13b; Species: zebra fish, Brachydanio rerio. BF T03598; HOXA1a; Species: zebra fish, Brachydanio rerio. BF T01698; HOXA2; Species: mouse, Mus musculus. BF T01699; HOXA2; Species: rat, Rattus norvegicus. BF T01700; HOXA2; Species: chick, Gallus domesticus. BF T03317; HOXA2; Species: human, Homo sapiens. BF T03780; HOXA2; Species: Japanese pufferfish, Fugu rubripes. BF T04472; HOXA2; Species: Horn shark, Heterodontus francisci. BF T03617; HOXA2b; Species: zebra fish, Brachydanio rerio. BF T00378; HOXA3; Species: mouse, Mus musculus. BF T03318; HOXA3; Species: human, Homo sapiens. BF T03781; HOXA3; Species: Japanese pufferfish, Fugu rubripes. BF T04474; HOXA3; Species: Horn shark, Heterodontus francisci. BF T03618; HOXA3a; Species: zebra fish, Brachydanio rerio. BF T00128; HOXA4; Species: chick, Gallus gallus. BF T01701; HOXA4; Species: mouse, Mus musculus. BF T01703; HOXA4; Species: human, Homo sapiens. BF T03784; HOXA4; Species: Japanese pufferfish, Fugu rubripes. BF T04475; HOXA4; Species: Horn shark, Heterodontus francisci. BF T03619; HOXA4a; Species: zebra fish, Brachydanio rerio. BF T00377; HOXA5; Species: mouse, Mus musculus. BF T01702; HOXA5; Species: human, Homo sapiens. BF T03305; HOXA5; Species: axolotl, Ambystoma mexicanum. BF T03788; HOXA5; Species: Japanese pufferfish, Fugu rubripes. BF T04476; HOXA5; Species: Horn shark, Heterodontus francisci. BF T03620; HOXA5a; Species: zebra fish, Brachydanio rerio. BF T03319; HOXA6; Species: human, Homo sapiens. BF T03338; HOXA6; Species: mouse, Mus musculus. BF T04477; HOXA6; Species: Horn shark, Heterodontus francisci. BF T01278; HOXA7; Species: mouse, Mus musculus. BF T01704; HOXA7; Species: clawed frog, Xenopus laevis. BF T01705; HOXA7; Species: human, Homo sapiens. BF T01706; HOXA7; Species: quail, Coturnix coturnix. BF T01707; HOXA7; Species: rat, Rattus norvegicus. BF T03621; HOXA7; Species: zebra fish, Brachydanio rerio. BF T04478; HOXA7; Species: Horn shark, Heterodontus francisci. BF T03622; HOXA8; Species: zebra fish, Brachydanio rerio. BF T01708; HOXA9; Species: chick, Gallus gallus. BF T01710; HOXA9; Species: mouse, Mus musculus. BF T01711; HOXA9; Species: guinea pig, Cavia sp. BF T03772; HOXA9; Species: Japanese pufferfish, Fugu rubripes. BF T04479; HOXA9; Species: Horn shark, Heterodontus francisci. BF T03623; HOXA9a; Species: zebra fish, Brachydanio rerio. BF T04361; HOXA9A; Species: human, Homo sapiens. BF T01709; HOXA9B; Species: human, Homo sapiens. BF T03624; HOXA9b; Species: zebra fish, Brachydanio rerio. BF T04132; HOXA9T; Species: mouse, Mus musculus. BF T01718; HOXB1; Species: chick, Gallus gallus. BF T01719; HOXB1; Species: human, Homo sapiens. BF T01720; HOXB1; Species: mouse, Mus musculus. BF T01721; HOXB1; Species: clawed frog, Xenopus laevis. BF T03306; HOXB1; Species: axolotl, Ambystoma mexicanum. BF T03773; HOXB1; Species: Japanese pufferfish, Fugu rubripes. BF T03638; HOXB10a; Species: zebra fish, Brachydanio rerio. BF T03802; HOXB13; Species: mouse, Mus musculus. BF T03803; HOXB13; Species: human, Homo sapiens. BF T03629; HOXB1a; Species: zebra fish, Brachydanio rerio. BF T03662; HOXB1b; Species: zebra fish, Brachydanio rerio. BF T03323; HOXB2; Species: human, Homo sapiens. BF T03783; HOXB2; Species: Japanese pufferfish, Fugu rubripes. BF T03630; HOXB2a; Species: zebra fish, Brachydanio rerio. BF T01722; HOXB3; Species: chick, Gallus gallus. BF T01723; HOXB3; Species: human, Homo sapiens. BF T01724; HOXB3; Species: mouse, Mus musculus. BF T01725; HOXB3; Species: clawed frog, Xenopus laevis. BF T03782; HOXB3; Species: Japanese pufferfish, Fugu rubripes. BF T03631; HOXB3a; Species: zebra fish, Brachydanio rerio. BF T01726; HOXB4; Species: chick, Gallus gallus. BF T01727; HOXB4; Species: human, Homo sapiens. BF T01728; HOXB4; Species: mouse, Mus musculus. BF T01729; HOXB4; Species: clawed frog, Xenopus laevis. BF T03774; HOXB4; Species: Japanese pufferfish, Fugu rubripes. BF T03632; HOXB4a; Species: zebra fish, Brachydanio rerio. BF T01730; HOXB5; Species: human, Homo sapiens. BF T01731; HOXB5; Species: mouse, Mus musculus. BF T03764; HOXB5; Species: clawed frog, Xenopus laevis. BF T03787; HOXB5; Species: Japanese pufferfish, Fugu rubripes. BF T03663; HOXB5a; Species: zebra fish, Brachydanio rerio. BF T03633; HOXB5b; Species: zebra fish, Brachydanio rerio. BF T01732; HOXB6; Species: human, Homo sapiens. BF T01733; HOXB6; Species: mouse, Mus musculus. BF T03790; HOXB6; Species: Japanese pufferfish, Fugu rubripes. BF T03664; HOXB6a; Species: zebra fish, Brachydanio rerio. BF T03634; HOXB6b; Species: zebra fish, Brachydanio rerio. BF T01734; HOXB7; Species: human, Homo sapiens. BF T01735; HOXB7; Species: mouse, Mus musculus. BF T01736; HOXB7; Species: clawed frog, Xenopus laevis. BF T03635; HOXB7a; Species: zebra fish, Brachydanio rerio. BF T00129; HOXB8; Species: chick, Gallus gallus. BF T01737; HOXB8; Species: mouse, Mus musculus. BF T03324; HOXB8; Species: human, Homo sapiens. BF T03791; HOXB8; Species: Japanese pufferfish, Fugu rubripes. BF T03665; HOXB8a; Species: zebra fish, Brachydanio rerio. BF T03636; HOXB8b; Species: zebra fish, Brachydanio rerio. BF T01738; HOXB9; Species: human, Homo sapiens. BF T01739; HOXB9; Species: mouse, Mus musculus. BF T01740; HOXB9; Species: clawed frog, Xenopus laevis. BF T03792; HOXB9; Species: Japanese pufferfish, Fugu rubripes. BF T03637; HOXB9a; Species: zebra fish, Brachydanio rerio. BF T03328; HOXC10; Species: human, Homo sapiens. BF T03350; HOXC10; Species: mouse, Mus musculus. BF T03794; HOXC10; Species: Japanese pufferfish, Fugu rubripes. BF T03645; HOXC10a; Species: zebra fish, Brachydanio rerio. BF T03233; HOXC11; Species: human, Homo sapiens. BF T03352; HOXC11; Species: mouse, Mus musculus. BF T03797; HOXC11; Species: Japanese pufferfish, Fugu rubripes. BF T03646; HOXC11a; Species: zebra fish, Brachydanio rerio. BF T03647; HOXC11b; Species: zebra fish, Brachydanio rerio. BF T03329; HOXC12; Species: human, Homo sapiens. BF T03353; HOXC12; Species: mouse, Mus musculus. BF T03799; HOXC12; Species: Japanese pufferfish, Fugu rubripes. BF T03648; HOXC12b; Species: zebra fish, Brachydanio rerio. BF T03330; HOXC13; Species: human, Homo sapiens. BF T03354; HOXC13; Species: mouse, Mus musculus. BF T03800; HOXC13; Species: Japanese pufferfish, Fugu rubripes. BF T03649; HOXC13a; Species: zebra fish, Brachydanio rerio. BF T03650; HOXC13b; Species: zebra fish, Brachydanio rerio. BF T03639; HOXC1a; Species: zebra fish, Brachydanio rerio. BF T03640; HOXC3a; Species: zebra fish, Brachydanio rerio. BF T03325; HOXC4; Species: human, Homo sapiens. BF T03340; HOXC4; Species: mouse, Mus musculus. BF T03785; HOXC4; Species: Japanese pufferfish, Fugu rubripes. BF T03641; HOXC4a; Species: zebra fish, Brachydanio rerio. BF T01741; HOXC5; Species: human, Homo sapiens. BF T03351; HOXC5; Species: mouse, Mus musculus. BF T03765; HOXC5; Species: clawed frog, Xenopus laevis. BF T03789; HOXC5; Species: Japanese pufferfish, Fugu rubripes. BF T03642; HOXC5a; Species: zebra fish, Brachydanio rerio. BF T01742; HOXC6; Species: human, Homo sapiens. BF T01747; HOXC6; Species: zebra fish, Brachydanio rerio. BF T03775; HOXC6; Species: Japanese pufferfish, Fugu rubripes. BF T01743; HOXC6 (PRI); Species: mouse, Mus musculus. BF T01745; HOXC6 (PRI); Species: clawed frog, Xenopus laevis. BF T01744; HOXC6 (PRII); Species: mouse, Mus musculus. BF T01746; HOXC6 (PRII); Species: clawed frog, Xenopus laevis. BF T03667; HOXC6a; Species: zebra fish, Brachydanio rerio. BF T03668; HOXC6b; Species: zebra fish, Brachydanio rerio. BF T01749; HOXC8; Species: mouse, Mus musculus. BF T03326; HOXC8; Species: human, Homo sapiens. BF T03777; HOXC8; Species: Japanese pufferfish, Fugu rubripes. BF T03643; HOXC8a; Species: zebra fish, Brachydanio rerio. BF T03327; HOXC9; Species: human, Homo sapiens. BF T03349; HOXC9; Species: mouse, Mus musculus. BF T03776; HOXC9; Species: Japanese pufferfish, Fugu rubripes. BF T03644; HOXC9a; Species: zebra fish, Brachydanio rerio. BF T01750; HOXD1; Species: mouse, Mus musculus. BF T01751; HOXD1; Species: clawed frog, Xenopus laevis. BF T01425; HOXD10; Species: human, Homo sapiens. BF T01757; HOXD10; Species: mouse, Mus musculus. BF T01758; HOXD10; Species: chick, Gallus gallus. BF T03654; HOXD10; Species: zebra fish, Brachydanio rerio. BF T03795; HOXD10; Species: Japanese pufferfish, Fugu rubripes. BF T04484; HOXD10; Species: Horn shark, Heterodontus francisci. BF T01759; HOXD11; Species: chick, Gallus gallus. BF T01760; HOXD11; Species: mouse, Mus musculus. BF T01761; HOXD11; Species: newt, Notophthalmus viridescens. BF T03333; HOXD11; Species: human, Homo sapiens. BF T03655; HOXD11; Species: zebra fish, Brachydanio rerio. BF T03798; HOXD11; Species: Japanese pufferfish, Fugu rubripes. BF T04485; HOXD11; Species: Horn shark, Heterodontus francisci. BF T01762; HOXD12; Species: chick, Gallus gallus. BF T01763; HOXD12; Species: mouse, Mus musculus. BF T03334; HOXD12; Species: human, Homo sapiens. BF T03656; HOXD12; Species: zebra fish, Brachydanio rerio. BF T04486; HOXD12; Species: Horn shark, Heterodontus francisci. BF T01764; HOXD13; Species: chick, Gallus gallus. BF T01765; HOXD13; Species: mouse, Mus musculus. BF T03335; HOXD13; Species: human, Homo sapiens. BF T03657; HOXD13; Species: zebra fish, Brachydanio rerio. BF T03801; HOXD13; Species: Japanese pufferfish, Fugu rubripes. BF T04487; HOXD13; Species: Horn shark, Heterodontus francisci. BF T03786; HOXD2; Species: Japanese pufferfish, Fugu rubripes. BF T03331; HOXD3; Species: human, Homo sapiens. BF T03339; HOXD3; Species: mouse, Mus musculus. BF T03651; HOXD3; Species: zebra fish, Brachydanio rerio. BF T00376; HOXD4; Species: human, Homo sapiens. BF T01752; HOXD4; Species: mouse, Mus musculus. BF T01753; HOXD4; Species: chick, Gallus gallus. BF T03652; HOXD4; Species: zebra fish, Brachydanio rerio. BF T04481; HOXD5; Species: Horn shark, Heterodontus francisci. BF T01426; HOXD8; Species: mouse, Mus musculus. BF T01754; HOXD8; Species: chick, Gallus gallus. BF T03332; HOXD8; Species: human, Homo sapiens. BF T04482; HOXD8; Species: Horn shark, Heterodontus francisci. BF T01424; HOXD9; Species: human, Homo sapiens. BF T01755; HOXD9; Species: mouse, Mus musculus. BF T01756; HOXD9; Species: chick, Gallus gallus. BF T03653; HOXD9; Species: zebra fish, Brachydanio rerio. BF T03793; HOXD9; Species: Japanese pufferfish, Fugu rubripes. BF T04483; HOXD9; Species: Horn shark, Heterodontus francisci. BF T04360; HPX42B; Species: human, Homo sapiens. BF T04098; HR1; Species: sunflower, Helianthus annuus. BF T02057; IPF1; Species: mouse, Mus musculus. BF T02058; IPF1; Species: rat, Rattus norvegicus. BF T04267; IPF1; Species: golden hamster, Mesocricetus auratus. BF T04362; IPF1; Species: human, Homo sapiens. BF T04540; IPF1; Species: sea squirt, Ciona intestinalis. BF T04541; IPF1; Species: clawed frog, Xenopus laevis. BF T04281; Irx-1; Species: mouse, Mus musculus. BF T04799; IRX-1; Species: human, Homo sapiens. BF T04282; Irx-2; Species: mouse, Mus musculus. BF T04291; Irx-2; Species: chick, Gallus gallus. BF T02437; Irx-3; Species: human, Homo sapiens. BF T02439; Irx-3; Species: mouse, Mus musculus. BF T04274; Irx-4; Species: chick, Gallus gallus. BF T04275; Irx-4; Species: human, Homo sapiens. BF T04276; Irx-4; Species: mouse, Mus musculus. BF T04283; Irx-5; Species: mouse, Mus musculus. BF T02436; IRX2a; Species: human, Homo sapiens. BF T02062; KN1; Species: maize, Zea mays. BF T04058; KN1; Species: tomato, Lycopersicon esculentum. BF T04060; KNAP1; Species: Apple, Malus domestica. BF T04061; KNAP2; Species: Apple, Malus domestica. BF T04062; KNAP3; Species: Apple, Malus domestica. BF T04043; KNAT1; Species: thale cress, Arabidopsis thaliana. BF T04042; KNAT2; Species: thale cress, Arabidopsis thaliana. BF T04044; KNAT3; Species: thale cress, Arabidopsis thaliana. BF T04045; KNAT4; Species: thale cress, Arabidopsis thaliana. BF T04049; KNAT5; Species: thale cress, Arabidopsis thaliana. BF T02063; Knox3; Species: barley, Hordeum vulgare L. BF T02064; Lab; Species: fruit fly, Drosophila melanogaster. BF T02065; Lab; Species: fruit fly, Drosophila pseudoobscura. BF T03830; lab; Species: woodlouse, Porcellio scaber. BF T03841; lab; Species: spider, Cupiennius salei. BF T03843; lab; Species: red flour beetle, Tribolium castaneum. BF T03852; lab; Species: firebrat, Thermobia domestica. BF T03861; lab; Species: sandworm, Nereis virens. BF T03870; lab; Species: Lingula anatina. BF T04317; Lbe; Species: fruit fly, Drosophila melanogaster. BF T04318; Lbl; Species: fruit fly, Drosophila melanogaster. BF T04315; Lbx1; Species: mouse, Mus musculus. BF T04316; LBX1; Species: human, Homo sapiens. BF T03291; LD; Species: thale cress, Arabidopsis thaliana. BF T04055; LET12; Species: tomato, Lycopersicon esculentum. BF T04057; LET6; Species: tomato, Lycopersicon esculentum. BF T03369; lin-39; Species: Caenorhabditis elegans. BF T03387; lin-39; Species: Pristionchus pacificus. BF T03747; lin-39; Species: Caenorhabditis briggsae. BF T03760; Lox-2; Species: leech, Helobdella robusta. BF T03756; Lox-20; Species: leech, Helobdella triserialis. BF T03762; Lox-4; Species: medicinal leech, Hirudo medicinalis. BF T03757; Lox-5; Species: leech, Helobdella triserialis. BF T03754; Lox-6; Species: leech, Helobdella robusta. BF T03751; Lox-7; Species: leech, Helobdella triserialis. BF T03866; Lox4; Species: sandworm, Nereis virens. BF T03875; Lox4; Species: Lingula anatina. BF T03867; Lox5; Species: sandworm, Nereis virens. BF T03874; Lox5; Species: Lingula anatina. BF T01816; Mab-18 (284 AA); Species: Caenorhabditis elegans. BF T01817; Mab-18 (296 AA); Species: Caenorhabditis elegans. BF T03368; mab-5; Species: Caenorhabditis elegans. BF T03386; mab-5; Species: Pristionchus pacificus. BF T03749; mab-5; Species: Caenorhabditis briggsae. BF T02089; mat1-Pc; Species: fission yeast, Schizosaccharomyces pombe. BF T00488; MATa1; Species: yeast, Saccharomyces cerevisiae. BF T00486; MATalpha1; Species: yeast, Saccharomyces cerevisiae. BF T01290; MATalpha1; Species: yeast, Kluyveromyces lactis. BF T00487; MATalpha2; Species: yeast, Saccharomyces cerevisiae. BF T03924; MBH1; Species: rat, Rattus norvegicus. BF T04775; MDH1; Species: Apple, Malus domestica. BF T03419; Meis-1; Species: human, Homo sapiens. BF T03390; Meis-1-1; Species: clawed frog, Xenopus laevis. BF T03391; Meis-1-2; Species: clawed frog, Xenopus laevis. BF T03411; Meis-1-3; Species: clawed frog, Xenopus laevis. BF T03410; Meis-1-4; Species: clawed frog, Xenopus laevis. BF T03388; Meis-1a; Species: mouse, Mus musculus. BF T03389; Meis-1b; Species: mouse, Mus musculus. BF T04129; Meis-1c; Species: mouse, Mus musculus. BF T03405; Meis-2a; Species: mouse, Mus musculus. BF T04115; Meis-2a; Species: human, Homo sapiens. BF T03407; Meis-2b; Species: mouse, Mus musculus. BF T04116; Meis-2b; Species: human, Homo sapiens. BF T03408; Meis-2c; Species: mouse, Mus musculus. BF T04117; Meis-2c; Species: human, Homo sapiens. BF T03409; Meis-2d; Species: mouse, Mus musculus. BF T04118; Meis-2d; Species: human, Homo sapiens. BF T04114; Meis-2e; Species: human, Homo sapiens. BF T03406; Meis-3; Species: mouse, Mus musculus. BF T03412; Meis-3; Species: human, Homo sapiens. BF T03413; Meis-3; Species: clawed frog, Xenopus laevis. BF T04046; Meox1; Species: human, Homo sapiens. BF T04047; Meox1; Species: mouse, Mus musculus. BF T04050; Meox1a; Species: human, Homo sapiens. BF T04005; Meox2; Species: human, Homo sapiens. BF T04048; Meox2; Species: mouse, Mus musculus. BF T04053; Meox2; Species: clawed frog, Xenopus laevis. BF T04054; Meox2; Species: rat, Rattus norvegicus. BF T02966; MHox; Species: mouse, Mus musculus. BF T02059; MHox (K-2); Species: human, Homo sapiens. BF T02060; MHox (K-2a); Species: mouse, Mus musculus. BF T02061; MHox (K-2b); Species: mouse, Mus musculus. BF T02438; Mirr; Species: fruit fly, Drosophila melanogaster. BF T03561; Mix.1; Species: clawed frog, Xenopus laevis. BF T03564; Mix.2; Species: clawed frog, Xenopus laevis. BF T03575; Mix.3; Species: clawed frog, Xenopus laevis. BF T03576; Mix.4; Species: clawed frog, Xenopus laevis. BF T03582; Mixer; Species: clawed frog, Xenopus laevis. BF T04800; MIXL1; Species: mouse, Mus musculus. BF T04801; MIXL1; Species: human, Homo sapiens. BF T04097; ML1; Species: thale cress, Arabidopsis thaliana. BF T03437; MNR2; Species: chick, Gallus gallus. BF T03551; Msh; Species: fruit fly, Drosophila melanogaster. BF T03738; Msh; Species: Chlorohydra viridissima. BF T02069; Msx-1; Species: chick, Gallus gallus. BF T02070; Msx-1; Species: chick, Gallus domesticus. BF T02071; Msx-1; Species: human, Homo sapiens. BF T02072; Msx-1; Species: mouse, Mus musculus. BF T02073; Msx-1; Species: newt, Notophthalmus viridescens. BF T02074; Msx-2; Species: chick, Gallus gallus. BF T02075; Msx-2; Species: human, Homo sapiens. BF T02076; Msx-2; Species: mouse, Mus musculus. BF T02077; Msx-2; Species: quail, Coturnix coturnix. BF T02106; Msx-2; Species: rat, Rattus norvegicus. BF T04367; NCX; Species: human, Homo sapiens. BF T04368; Ncx; Species: mouse, Mus musculus. BF T01083; NF-muNR; Species: mouse, Mus musculus. BF T04257; NK-1; Species: fruit fly, Drosophila melanogaster. BF T04258; NK-2; Species: fruit fly, Drosophila melanogaster. BF T04271; Nkx2-1; Species: chick, Gallus gallus. BF T04335; Nkx2-10; Species: clawed frog, Xenopus laevis. BF T02384; Nkx2-2; Species: mouse, Mus musculus. BF T04265; Nkx2-2; Species: golden hamster, Mesocricetus auratus. BF T04272; Nkx2-2; Species: chick, Gallus gallus. BF T04325; Nkx2-3; Species: mouse, Mus musculus. BF T04333; Nkx2-3; Species: chick, Gallus gallus. BF T04329; Nkx2-3a; Species: clawed frog, Xenopus laevis. BF T04331; Nkx2-3b1; Species: clawed frog, Xenopus laevis. BF T04332; Nkx2-3b2; Species: clawed frog, Xenopus laevis. BF T01675; Nkx2-5; Species: mouse, Mus musculus. BF T04323; NKX2-5; Species: human, Homo sapiens. BF T04330; Nkx2-5; Species: clawed frog, Xenopus laevis. BF T04334; Nkx2-5; Species: chick, Gallus gallus. BF T04342; Nkx2-6; Species: mouse, Mus musculus. BF T04340; Nkx2-8; Species: chick, Gallus gallus. BF T04338; Nkx2-9; Species: mouse, Mus musculus. BF T04337; NKX2B; Species: human, Homo sapiens. BF T04341; NKX2C; Species: human, Homo sapiens. BF T04336; NKX2G; Species: human, Homo sapiens. BF T04256; Nkx3-1; Species: mouse, Mus musculus. BF T02667; Nkx3-2; Species: mouse, Mus musculus. BF T04255; NKX3A; Species: human, Homo sapiens. BF T04287; NKX3A v1; Species: human, Homo sapiens. BF T04288; NKX3A v2; Species: human, Homo sapiens. BF T04289; NKX3A v3; Species: human, Homo sapiens. BF T04290; NKX3A v4; Species: human, Homo sapiens. BF T02668; NKX3B; Species: human, Homo sapiens. BF T04261; Nkx6-1; Species: golden hamster, Mesocricetus auratus. BF T04269; Nkx6-1; Species: mouse, Mus musculus. BF T04270; Nkx6-1; Species: chick, Gallus gallus. BF T04297; Nkx6-1; Species: rat, Rattus norvegicus. BF T02050; Nkx6-2; Species: mouse, Mus musculus. BF T04268; NKX6A; Species: human, Homo sapiens. BF T04787; NKX6B; Species: human, Homo sapiens. BF T03381; nob-1A; Species: Caenorhabditis elegans. BF T03382; nob-1B; Species: Caenorhabditis elegans. BF T04063; NTH15; Species: tobacco, Nicotiana tabacum. BF T04099; O39; Species: Phalaenopsis sp. BF T03259; OC-2; Species: human, Homo sapiens. BF T03308; OG-2; Species: mouse, Mus musculus. BF T03309; OG-9; Species: mouse, Mus musculus. BF T03732; Om(1D); Species: fruit fly, Drosophila ananassae. BF T04182; OSH42; Species: rice, Oryza sativa. BF T04183; OSH44; Species: rice, Oryza sativa. BF T04034; OSH45; Species: rice, Oryza sativa. BF T04033; OSKN1; Species: rice, Oryza sativa. BF T04035; OSKN2; Species: rice, Oryza sativa. BF T04036; OSKN3; Species: rice, Oryza sativa. BF T02078; Otd; Species: fruit fly, Drosophila melanogaster. BF T02079; Otx1; Species: human, Homo sapiens. BF T02080; Otx1; Species: mouse, Mus musculus. BF T02081; Otx1; Species: rat, Rattus norvegicus. BF T03521; Otx1; Species: clawed frog, Xenopus laevis. BF T02082; Otx2; Species: human, Homo sapiens. BF T02083; Otx2; Species: mouse, Mus musculus. BF T03522; Otx2; Species: clawed frog, Xenopus laevis. BF T03523; Otx4; Species: clawed frog, Xenopus laevis. BF T03378; pal-1; Species: Caenorhabditis elegans. BF T02084; Pb; Species: fruit fly, Drosophila melanogaster. BF T02086; Pb; Species: fruit fly, Drosophila pseudoobscura. BF T03831; pb; Species: woodlouse, Porcellio scaber. BF T03844; pb; Species: red flour beetle, Tribolium castaneum. BF T03853; pb; Species: firebrat, Thermobia domestica. BF T03862; pb; Species: sandworm, Nereis virens. BF T01481; Pbx-1a; Species: human, Homo sapiens. BF T03451; Pbx-1a; Species: mouse, Mus musculus. BF T02087; Pbx-1b; Species: human, Homo sapiens. BF T02088; Pbx-1b; Species: mouse, Mus musculus. BF T04123; Pbx-2; Species: human, Homo sapiens. BF T04127; Pbx-2; Species: mouse, Mus musculus. BF T04124; Pbx-3a; Species: human, Homo sapiens. BF T04125; Pbx-3a; Species: mouse, Mus musculus. BF T04126; Pbx-3b; Species: mouse, Mus musculus. BF T04128; Pbx-3b; Species: human, Homo sapiens. BF T00693; Pc; Species: fruit fly, Drosophila melanogaster. BF T00689; PHO2; Species: yeast, Saccharomyces cerevisiae. BF T02090; Phox2a; Species: mouse, Mus musculus. BF T03976; Phox2b; Species: mouse, Mus musculus. BF T03383; php-3; Species: Caenorhabditis elegans. BF T03422; PIHbox9; Species: sea urchin, Paracentrotus lividus. BF T02415; Pitx1; Species: mouse, Mus musculus. BF T02455; PITX1; Species: human, Homo sapiens. BF T02410; Pitx2; Species: mouse, Mus musculus. BF T02413; PITX2; Species: human, Homo sapiens. BF T02412; Pitx2B; Species: mouse, Mus musculus. BF T02666; Pitx3; Species: mouse, Mus musculus. BF T04305; Pitx3; Species: rat, Rattus norvegicus. BF T04311; PITX3; Species: human, Homo sapiens. BF T04121; PKNOX1; Species: mouse, Mus musculus. BF T04122; PKNOX1; Species: human, Homo sapiens. BF T03959; Pmx2a; Species: human, Homo sapiens. BF T03961; Pmx2b; Species: human, Homo sapiens. BF T03868; Post1; Species: sandworm, Nereis virens. BF T03876; Post1; Species: Lingula anatina. BF T03869; Post2; Species: sandworm, Nereis virens. BF T03877; Post2; Species: Lingula anatina. BF T03721; Prox-1; Species: sponge, Ephydatia fluviatilis. BF T03724; Prox-2; Species: sponge, Ephydatia fluviatilis. BF T03725; Prox-3; Species: sponge, Ephydatia fluviatilis. BF T04922; PROX1; Species: human, Homo sapiens. BF T03294; Psx-1; Species: mouse, Mus musculus. BF T03295; Psx-2; Species: mouse, Mus musculus. BF T03502; Rax; Species: mouse, Mus musculus. BF T00732; Ro; Species: fruit fly, Drosophila melanogaster. BF T02093; Ro; Species: fruit fly, Drosophila virilis. BF T04032; RS1; Species: maize, Zea mays. BF T03511; Rx; Species: fruit fly, Drosophila melanogaster. BF T03503; Rx1; Species: clawed frog, Xenopus laevis. BF T03508; Rx1; Species: zebra fish, Brachydanio rerio. BF T03504; Rx2; Species: clawed frog, Xenopus laevis. BF T03509; Rx2; Species: zebra fish, Brachydanio rerio. BF T03510; Rx3; Species: zebra fish, Brachydanio rerio. BF T01483; S8; Species: mouse, Mus musculus. BF T02094; S8; Species: chick, Gallus gallus. BF T04052; SBH-1; Species: soybean, Glycine max. BF T02096; Scr; Species: fruit fly, Drosophila melanogaster. BF T03833; Scr; Species: woodlouse, Porcellio scaber. BF T03846; Scr; Species: red flour beetle, Tribolium castaneum. BF T03855; Scr; Species: firebrat, Thermobia domestica. BF T03859; Scr; Species: house cricket, Acheta domesticus. BF T03860; Scr; Species: milkweed bug, Oncopeltus fasciatus. BF T03865; Scr; Species: sandworm, Nereis virens. BF T03872; Scr; Species: Lingula anatina. BF T03310; Shox2a; Species: mouse, Mus musculus. BF T04223; SHOX2a; Species: human, Homo sapiens. BF T04240; Shox2a; Species: rat, Rattus norvegicus. BF T04239; Shox2a-delta; Species: rat, Rattus norvegicus. BF T04224; SHOX2b; Species: human, Homo sapiens. BF T04233; Shox2b; Species: mouse, Mus musculus. BF T04241; Shox2b; Species: rat, Rattus norvegicus. BF T04226; SHOXa; Species: human, Homo sapiens. BF T04228; SHOXb; Species: human, Homo sapiens. BF T03262; Six-1; Species: mouse, Mus musculus. BF T03292; Six-1; Species: human, Homo sapiens. BF T03261; Six-2; Species: mouse, Mus musculus. BF T03267; Six-2; Species: human, Homo sapiens. BF T03282; Six-3; Species: human, Homo sapiens. BF T03347; Six-3; Species: fruit fly, Drosophila melanogaster. BF T03482; Six-3; Species: chick, Gallus gallus. BF T03263; Six-3alpha; Species: mouse, Mus musculus. BF T03270; Six-3beta; Species: mouse, Mus musculus. BF T03344; Six-4; Species: human, Homo sapiens. BF T03348; Six-4; Species: fruit fly, Drosophila melanogaster. BF T03264; Six-4A; Species: mouse, Mus musculus. BF T03265; Six-4B; Species: mouse, Mus musculus. BF T03266; Six-4C; Species: mouse, Mus musculus. BF T03271; Six-5; Species: mouse, Mus musculus. BF T03283; Six-5; Species: human, Homo sapiens. BF T03272; Six-6; Species: mouse, Mus musculus. BF T03279; Six-6; Species: human, Homo sapiens. BF T03273; So; Species: fruit fly, Drosophila. BF T02416; SpOtx; Species: sea urchin, Strongylocentrotus purpuratus. BF T02097; STM; Species: thale cress, Arabidopsis thaliana. BF T04076; TGIF; Species: human, Homo sapiens. BF T04077; TGIF; Species: mouse, Mus musculus. BF T04131; TGIF2; Species: human, Homo sapiens. BF T03612; Tin; Species: fruit fly, Drosophila melanogaster. BF T04313; TLX3; Species: human, Homo sapiens. BF T04314; Tlx3; Species: mouse, Mus musculus. BF T04588; TOS8; Species: yeast, Saccharomyces cerevisiae. BF T00856; TTF-1; Species: rat, Rattus norvegicus. BF T00857; TTF-1; Species: human, Homo sapiens. BF T00858; TTF-1; Species: chick, Gallus gallus. BF T00859; TTF-1; Species: mouse, Mus musculus. BF T01518; TTF-1; Species: cattle, Bos taurus. BF T02098; TTF-1; Species: dog, Canis canis. BF T00863; Ubx; Species: fruit fly, Drosophila melanogaster. BF T02101; Ubx; Species: fruit fly, Drosophila pseudoobscura. BF T02102; Ubx; Species: fruit fly, Drosophila funebris. BF T03848; Ubx; Species: red flour beetle, Tribolium castaneum. BF T03838; Ubx-1; Species: spider, Cupiennius salei. BF T03837; Ubx-2; Species: spider, Cupiennius salei. BF T03371; unc-30; Species: Caenorhabditis elegans. BF T02991; unc-4; Species: Caenorhabditis elegans. BF T03307; Uncx-4.1; Species: mouse, Mus musculus. BF T03372; vab-7; Species: Caenorhabditis elegans. BF T03274; Vax-1; Species: mouse, Mus musculus. BF T03275; Vax-1; Species: clawed frog, Xenopus laevis. BF T03345; Vax-1; Species: rat, Rattus norvegicus. BF T03276; Vax-2; Species: mouse, Mus musculus. BF T03277; Vax-2; Species: human, Homo sapiens. BF T03278; Vax-2; Species: clawed frog, Xenopus laevis. BF T03346; Vax-2; Species: rat, Rattus norvegicus. BF T04266; Vdx; Species: golden hamster, Mesocricetus auratus. BF T04143; Vsx-1; Species: goldfish, Carassius auratus. BF T04144; Vsx-1; Species: zebra fish, Brachydanio rerio. BF T03941; XBH1; Species: clawed frog, Xenopus laevis. BF T03942; XBH2; Species: clawed frog, Xenopus laevis. BF T03939; Xbr-1a; Species: clawed frog, Xenopus laevis. BF T03938; Xbr-1b; Species: clawed frog, Xenopus laevis. BF T02433; Xiro1; Species: clawed frog, Xenopus laevis. BF T02434; Xiro2; Species: clawed frog, Xenopus laevis. BF T02435; Xiro3; Species: clawed frog, Xenopus laevis. BF T04665; Xvent-1; Species: clawed frog, Xenopus laevis. BF T04663; Xvent-2; Species: clawed frog, Xenopus laevis. BF T04357; YHP1; Species: yeast, Saccharomyces cerevisiae. BF T00917; Zen-1; Species: fruit fly, Drosophila melanogaster. BF T02099; Zen-2; Species: fruit fly, Drosophila melanogaster. XX DR Prosite: PS00027. XX RN [1] RX MEDLINE; 92034974. RA Wolberger C. Vershon A. K. Liu B. Johnson A. D. Pabo C. O. RT Crystal structure of a MATalpha2 homeodomain-operator complex suggests a RT general model for homeodomain-DNA interactions RL Cell 67:517-528 (1991). RN [2] RX MEDLINE; 91224486. RA Phillips C. L. Vershon A. K. Johnson A. D. Dahlquist F. W. RT Secondary structure of the homeo domain of yeast alpha2 repressor RT determined by NMR spectroscopy RL Genes Dev. 5:764-772 (1991). RN [3] RX MEDLINE; 91029489. RA Kissinger C. R. Liu B. Martin-Blanco E. Kornberg T. B. Pabo C. O. RT Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A RT resolution: a framework for understanding homeodomain-DNA interactions RL Cell 63:579-590 (1990). RN [4] RX MEDLINE; 91006000. RA Otting G. Qian Y. Q. Billeter M. Mueller M. Affolter M. Gehring W. J. RA Wuethrich K. RT Protein-DNA contacts in the structure of a homeodomain-DNA complex RT determined by nuclear magnetic resonance spectroscopy in solution RL EMBO J. 9:3085-3092 (1990). RN [5] RX MEDLINE; 89043970. RA Mihara H. Kaiser E. T. RT A chemically synthesized Antennapedia homeo domain binds to a specific DNA RT sequence RL Science 242:925-927 (1988). RN [6] RX MEDLINE; 89006213. RA Krause H. M. Klemenz R. Gehring W. J. RT Expression, modification, and localization of the fushi tarazu protein in RT Drosophila embryos RL Genes Dev. 2:1021-1036 (1988). XX // AC C0007 XX ID POU XX DT 25.09.1993 (created); ewi. DT 05.02.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL POU domain XX CC The POU domain consists of a POU-specific box and an appropriately spaced CC homeodomain. The POU-specific box consists of two subdomains (A and B), CC each of them probably comprising an alpha-helix and enriched in basic or CC hydroxyl amino acids, resp. The POU-specific box bends DNA. The term POU is CC derived from Pit-1, Oct-factors and Unc-86. XX BF T01883; ceh-18; Species: Caenorhabditis elegans. BF T01897; Cf1a; Species: fruit fly, Drosophila melanogaster. BF T00369; HNF-1; Species: rat, Rattus norvegicus. BF T01952; HNF-1; Species: chick, Gallus gallus. BF T00368; HNF-1A; Species: human, Homo sapiens. BF T01180; HNF-1A; Species: domestic pig, Sus scrofa. BF T01211; HNF-1A; Species: mouse, Mus musculus. BF T00889; HNF-1B; Species: rat, Rattus norvegicus. BF T00890; HNF-1B; Species: mouse, Mus musculus. BF T01950; HNF-1B; Species: human, Homo sapiens. BF T01951; HNF-1C; Species: human, Homo sapiens. BF T01898; I-POU; Species: fruit fly, Drosophila melanogaster. BF T00545; NF-A; Species: human, Homo sapiens. BF T01191; NF-A; Species: monkey, Cercopithecus aethiops. BF T01192; NF-A; Species: mouse, Mus musculus. BF T00645; Oct-10; Species: mouse, Mus musculus. BF T01875; Oct-2; Species: fruit fly, Drosophila melanogaster. BF T00659; Oct-9; Species: mouse, Mus musculus. BF T01900; PDM-1; Species: fruit fly, Drosophila melanogaster. BF T01901; PDM-2; Species: fruit fly, Drosophila melanogaster. BF T01894; pou[c]; Species: zebra fish, Brachydanio rerio. BF T00325; POU1F1; Species: human, Homo sapiens. BF T01172; POU1F1; Species: mouse, Mus musculus. BF T00691; POU1F1a; Species: rat, Rattus norvegicus. BF T01516; POU1F1b; Species: rat, Rattus norvegicus. BF T01902; POU1F1c; Species: rat, Rattus norvegicus. BF T01895; Pou2; Species: zebra fish, Brachydanio rerio. BF T00641; POU2F1; Species: human, Homo sapiens. BF T00642; POU2F1; Species: clawed frog, Xenopus laevis. BF T00643; POU2F1; Species: rat, Rattus norvegicus. BF T01031; POU2F1; Species: chick, Gallus gallus. BF T01466; POU2F1; Species: hamster, Cricetulus griseus. BF T00644; POU2F1a; Species: mouse, Mus musculus. BF T01862; POU2F1b; Species: mouse, Mus musculus. BF T01863; POU2F1c; Species: mouse, Mus musculus. BF T00647; POU2F2; Species: human, Homo sapiens. BF T00648; POU2F2; Species: mouse, Mus musculus. BF T00650; POU2F2; Species: rat, Rattus rattus. BF T00646; POU2F2 (Oct-2.1); Species: human, Homo sapiens. BF T01864; POU2F2 (Oct-2.1); Species: mouse, Mus musculus. BF T01870; POU2F2 (Oct-2.1); Species: rat, Rattus rattus. BF T01865; POU2F2 (Oct-2.3); Species: mouse, Mus musculus. BF T01866; POU2F2 (Oct-2.4); Species: mouse, Mus musculus. BF T01867; POU2F2 (Oct-2.6); Species: mouse, Mus musculus. BF T01868; POU2F2 (Oct-2.7); Species: rat, Rattus rattus. BF T01869; POU2F2 (Oct-2.8); Species: rat, Rattus rattus. BF T00662; POU2F2B; Species: human, Homo sapiens. BF T00964; POU2F2B; Species: mouse, Mus musculus. BF T01871; POU2F2B; Species: rat, Rattus rattus. BF T01874; POU2F3; Species: mouse, Mus musculus. BF T00655; POU3F1; Species: human, Homo sapiens. BF T00656; POU3F1; Species: mouse, Mus musculus. BF T00969; POU3F1; Species: rat, Rattus norvegicus. BF T00630; POU3F2; Species: human, Homo sapiens. BF T01524; POU3F2; Species: rat, Rattus norvegicus. BF T01873; POU3F2; Species: mouse, Mus musculus. BF T00658; POU3F3; Species: mouse, Mus musculus. BF T04469; POU3F3; Species: human, Homo sapiens. BF T01884; POU3F4; Species: mouse, Mus musculus. BF T01885; POU3F4; Species: rat, Rattus norvegicus. BF T01886; POU3F4; Species: human, Homo sapiens. BF T01887; POU3F4; Species: clawed frog, Xenopus laevis. BF T01879; POU4F1; Species: rat, Rattus norvegicus. BF T01877; POU4F1(l); Species: mouse, Mus musculus. BF T04463; POU4F1(l); Species: human, Homo sapiens. BF T01876; POU4F1(s); Species: human, Homo sapiens. BF T01878; POU4F1(s); Species: mouse, Mus musculus. BF T01880; POU4F2; Species: human, Homo sapiens. BF T01881; POU4F2; Species: mouse, Mus musculus. BF T04461; POU4F3; Species: human, Homo sapiens. BF T04462; POU4F3; Species: mouse, Mus musculus. BF T00651; POU5F1; Species: mouse, Mus musculus. BF T00653; POU5F1 (Oct-5); Species: mouse, Mus musculus. BF T00652; POU5F1A; Species: human, Homo sapiens. BF T01872; POU5F1B; Species: human, Homo sapiens. BF T04471; POU5F1C; Species: human, Homo sapiens. BF T01891; POU6F1; Species: rat, Rattus norvegicus. BF T04470; POU6F1; Species: human, Homo sapiens. BF T01889; POU6F1 (c1); Species: mouse, Mus musculus. BF T01888; POU6F1 (c2); Species: mouse, Mus musculus. BF T01890; POU6F1 (c7); Species: mouse, Mus musculus. BF T01892; Sprm-1; Species: rat, Rattus norvegicus. BF T01896; t-Pou2; Species: zebra fish, Brachydanio rerio. BF T01893; TCFbeta1; Species: human, Homo sapiens. BF T01899; tI-POU; Species: fruit fly, Drosophila melanogaster. BF T01882; unc-86; Species: Caenorhabditis elegans. BF T01955; vHNF-1; Species: domestic pig, Sus scrofa. BF T00891; vHNF-1A; Species: human, Homo sapiens. BF T01953; vHNF-1B; Species: human, Homo sapiens. BF T01954; vHNF-1C; Species: human, Homo sapiens. XX DR Prosite: PS00035, PS00465, PS00027. XX RN [1] RX MEDLINE; 92007745. RA Verrijzer C. P. van Oosterhout J. A. W. M. van Weperen W. W. van der Vliet RA P. C. RT POU proteins bend DNA via the POU-specific domain RL EMBO J. 10:3007-3014 (1991). RN [2] RX MEDLINE; 92142231. RA Schoeler H. R. RT Octamania: The POU factors in murine development RL Trends Genet. 7:323-329 (1991). RN [3] RX MEDLINE; 89051866. RA Finney M. Ruvkun G. Horvitz H. R. RT The C. elegans cell lineage and differentiation gene unc-86 encodes a RT protein with a homeodomain and extended similarity to transcription factors RL Cell 55:757-769 (1988). RN [4] RX MEDLINE; 89070684. RA Sturm R. A. Herr W. RT The POU domain is a bipartite DNA-binding structure RL Nature 336:601-604 (1988). RN [5] RX MEDLINE; 89070683. RA Thali M. Mueller M. M. DeLorenzi M. Matthias P. Bienz M. RT Drosophila homoeotic genes encode transcriptional activators similar to RT mammalian OTF-2 RL Nature 336:598-601 (1988). XX // AC C0008 XX ID bZIP XX DT 25.09.1993 (created); ewi. DT 02.03.1995 (updated); dbo. CO Copyright (C), Biobase GmbH. XX CL basic region + leucine zipper XX CC A DNA-binding basic region is followed by a leucine zipper. The leucine CC zipper consists of repeated leucine residues at every seventh position and CC mediates protein dimerization as a prerequisite for DNA-binding. The CC leucines are directed towards one side of an alpha-helix. The leucine side CC chains of two polypeptides are thought to interdigitate upon dimerization CC (knobs-into-holes model). The leucine zipper dictates dimerization CC specificity. Upon DNA-binding of the dimer, the basic regions adopt CC alpha-helical conformation as well. Possibly, a sharp angulation point CC separates two alpha-helices of the subregions A and B leading to the CC scissors grip model for the bZIP-DNA complex. The DNA is contacted through CC the major groove over a whole turn. (PROSITE motif for Fos-Jun bZIP region CC only!) XX BF T03820; ABF1; Species: thale cress, Arabidopsis thaliana. BF T03823; ABF2; Species: thale cress, Arabidopsis thaliana. BF T03824; ABF3; Species: thale cress, Arabidopsis thaliana. BF T03825; ABF4; Species: thale cress, Arabidopsis thaliana. BF T04543; ABI5; Species: thale cress, Arabidopsis thaliana. BF T04565; ACA1; Species: yeast, Saccharomyces cerevisiae. BF T00027; AP-1; Species: clawed frog, Xenopus. BF T00029; AP-1; Species: human, Homo sapiens. BF T00030; AP-1; Species: monkey, Cercopithecus aethiops. BF T00031; AP-1; Species: rat, Rattus norvegicus. BF T00032; AP-1; Species: mouse, Mus musculus. BF T03199; ARR1; Species: yeast, Saccharomyces cerevisiae. BF T02783; ATB-2; Species: thale cress, Arabidopsis thaliana. BF T00051; ATF; Species: human, Homo sapiens. BF T00968; ATF-1; Species: human, Homo sapiens. BF T01304; ATF-1; Species: mouse, Mus musculus. BF T00052; ATF-a; Species: human, Homo sapiens. BF T00053; ATF-adelta; Species: human, Homo sapiens. BF T00050; atf1; Species: fission yeast, Schizosaccharomyces pombe. BF T01095; ATF3; Species: rat, Rattus norvegicus. BF T01313; ATF3; Species: human, Homo sapiens. BF T04850; ATF3; Species: mouse, Mus musculus. BF T01325; ATF3 deltaZIP; Species: human, Homo sapiens. BF T01303; ATF4; Species: human, Homo sapiens. BF T04854; ATF4; Species: mouse, Mus musculus. BF T02052; ATF4 (381AA); Species: mouse, Mus musculus. BF T04877; ATF5; Species: human, Homo sapiens. BF T04742; ATF6; Species: human, Homo sapiens. BF T04791; Bach1; Species: human, Homo sapiens. BF T04793; Bach1; Species: mouse, Mus musculus. BF T04798; Bach1t; Species: human, Homo sapiens. BF T04792; Bach2; Species: mouse, Mus musculus. BF T04795; Bach2; Species: human, Homo sapiens. BF T02784; BLZ-1; Species: barley, Hordeum vulgare. BF T03987; BLZ-2; Species: barley, Hordeum vulgare. BF T02789; bZIP910; Species: garden snapdragon, Antirrhinum majus. BF T02790; bZIP911; Species: garden snapdragon, Antirrhinum majus. BF T00122; c-Fos; Species: mouse, Mus musculus. BF T00123; c-Fos; Species: human, Homo sapiens. BF T00124; c-Fos; Species: rat, Rattus norvegicus. BF T00125; c-Fos; Species: chick, Gallus gallus. BF T02205; c-Fos; Species: Japanese pufferfish, Fugu rubripes. BF T00131; c-Jun; Species: mouse, Mus musculus. BF T00132; c-Jun; Species: rat, Rattus norvegicus. BF T00133; c-Jun; Species: human, Homo sapiens. BF T00134; c-Jun; Species: chick, Gallus gallus. BF T01976; c-Jun; Species: quail, Coturnix coturnix. BF T02830; c-Jun; Species: domestic pig, Sus scrofa. BF T01432; c-Maf; Species: mouse, Mus musculus. BF T01431; c-Maf (long form); Species: chick, Gallus gallus. BF T02201; c-Maf (short form); Species: chick, Gallus gallus. BF T00106; C/EBP; Species: fruit fly, Drosophila melanogaster. BF T01386; C/EBP; Species: Aplysia, Aplysia californica. BF T01388; C/EBP; Species: clawed frog, Xenopus laevis. BF T02029; C/EBP; Species: fruit fly, Drosophila virilis. BF T00104; C/EBPalpha; Species: mouse, Mus musculus. BF T00105; C/EBPalpha; Species: human, Homo sapiens. BF T00107; C/EBPalpha; Species: chick, Gallus gallus. BF T00108; C/EBPalpha; Species: rat, Rattus norvegicus. BF T02359; C/EBPalpha(p20); Species: mouse, Mus musculus. BF T02025; C/EBPalpha(p30); Species: chick, Gallus gallus. BF T02026; C/EBPalpha(p30); Species: mouse, Mus musculus. BF T02027; C/EBPalpha(p30); Species: rat, Rattus norvegicus. BF T00017; C/EBPbeta; Species: mouse, Mus musculus. BF T00459; C/EBPbeta; Species: rat, Rattus norvegicus. BF T00581; C/EBPbeta; Species: human, Homo sapiens. BF T02022; C/EBPbeta; Species: chick, Gallus gallus. BF T01420; C/EBPbeta(p20); Species: rat, Rattus norvegicus. BF T02360; C/EBPbeta(p20); Species: mouse, Mus musculus. BF T02105; C/EBPbeta(p34); Species: rat, Rattus norvegicus. BF T00109; C/EBPdelta; Species: rat, Rattus norvegicus. BF T00583; C/EBPdelta; Species: human, Homo sapiens. BF T01114; C/EBPdelta; Species: mouse, Mus musculus. BF T00171; C/EBPepsilon; Species: rat, Rattus norvegicus. BF T04883; C/EBPepsilon; Species: human, Homo sapiens. BF T00216; C/EBPgamma; Species: mouse, Mus musculus. BF T02028; C/EBPgamma; Species: rat, Rattus norvegicus. BF T04884; C/EBPgamma; Species: human, Homo sapiens. BF T01239; CAD1; Species: yeast, Saccharomyces cerevisiae. BF T03583; ces-2; Species: Caenorhabditis elegans. BF T00127; CHOP-10; Species: mouse, Mus musculus. BF T03232; CIN5; Species: yeast, Saccharomyces cerevisiae. BF T01998; Cnc; Species: fruit fly, Drosophila melanogaster. BF T00160; CPC1; Species: Neurospora crassa. BF T01091; CPRF-1; Species: parsley, Petroselinum crispum (P. hortense). BF T01092; CPRF-2; Species: parsley, Petroselinum crispum (P. hortense). BF T01093; CPRF-3; Species: parsley, Petroselinum crispum (P. hortense). BF T02677; CPRF-4a; Species: parsley, Petroselinum crispum (P. hortense). BF T02678; CPRF-4b; Species: parsley, Petroselinum crispum (P. hortense). BF T00167; CRE-BP1; Species: human, Homo sapiens. BF T02056; CRE-BP1; Species: mouse, Mus musculus. BF T01017; CRE-BP2; Species: mouse, Mus musculus. BF T01382; CRE-BP2; Species: rat, Rattus norvegicus. BF T02036; CRE-BP3; Species: mouse, Mus musculus. BF T01308; CRE-BPa; Species: human, Homo sapiens. BF T00163; CREB; Species: human, Homo sapiens. BF T00164; CREB; Species: rat, Rattus norvegicus. BF T00989; CREB; Species: mouse, Mus musculus. BF T02361; CREBbeta; Species: mouse, Mus musculus. BF T01314; CREMalpha; Species: mouse, Mus musculus. BF T01803; CREMalpha; Species: human, Homo sapiens. BF T01315; CREMbeta; Species: mouse, Mus musculus. BF T01601; CREMdeltaC-F; Species: rat, Rattus norvegicus. BF T01600; CREMdeltaC-G; Species: rat, Rattus norvegicus. BF T01317; CREMepsilon; Species: mouse, Mus musculus. BF T01316; CREMgamma; Species: mouse, Mus musculus. BF T01309; CREMtau; Species: mouse, Mus musculus. BF T01919; CREMtau; Species: rat, Rattus norvegicus. BF T02108; CREMtau1; Species: mouse, Mus musculus. BF T02109; CREMtau2; Species: mouse, Mus musculus. BF T01602; CREMtaualpha; Species: mouse, Mus musculus. BF T02311; CSE2; Species: yeast, Saccharomyces cerevisiae. BF T03704; CST6; Species: yeast, Saccharomyces cerevisiae. BF T00180; CYS3; Species: Neurospora crassa. BF T00183; DBP; Species: rat, Rattus norvegicus. BF T04875; DBP; Species: human, Homo sapiens. BF T01603; dCREB-A; Species: fruit fly, Drosophila melanogaster. BF T01604; dCREB2-a; Species: fruit fly, Drosophila melanogaster. BF T00165; deltaCREB; Species: rat, Rattus norvegicus. BF T00166; deltaCREB; Species: human, Homo sapiens. BF T01311; deltaCREB; Species: mouse, Mus musculus. BF T01997; dFRA; Species: fruit fly, Drosophila melanogaster. BF T01996; dJRA; Species: fruit fly, Drosophila melanogaster. BF T04363; DPBF-1; Species: sunflower, Helianthus annuus. BF T04364; DPBF-2; Species: sunflower, Helianthus annuus. BF T01428; E4BP4; Species: human, Homo sapiens. BF T01598; ECH; Species: chick, Gallus gallus. BF T02669; EmBP-1a; Species: wheat, Triticum aestivum. BF T04819; EmBP-1a; Species: maize, Zea mays. BF T01098; EmBP-1b; Species: wheat, Triticum aestivum. BF T00291; FosB; Species: mouse, Mus musculus. BF T02198; FosB/SF; Species: mouse, Mus musculus. BF T00292; Fra-1; Species: mouse, Mus musculus. BF T01208; Fra-1; Species: rat, Rattus rattus. BF T01462; Fra-1; Species: human, Homo sapiens. BF T01990; Fra-2; Species: chick, Gallus gallus. BF T01991; Fra-2; Species: human, Homo sapiens. BF T02199; Fra-2; Species: mouse, Mus musculus. BF T02200; Fra-2; Species: rat, Rattus norvegicus. BF T02330; G/HBF-1; Species: soybean, Glycine max. BF T00299; GADD 153; Species: chinese hamster, Cricetulus longicaudatus. BF T01078; GBF1; Species: thale cress, Arabidopsis thaliana. BF T02463; GBF1; Species: maize, Zea mays. BF T02672; GBF1; Species: soybean, Glycine max. BF T02676; GBF12; Species: tomato, Lycopersicon esculentum. BF T02798; GBF1A; Species: rape, Brassica napus. BF T02799; GBF1B; Species: rape, Brassica napus. BF T01079; GBF2; Species: thale cress, Arabidopsis thaliana. BF T02674; GBF2A; Species: soybean, Glycine max. BF T02800; GBF2A; Species: rape, Brassica napus. BF T02675; GBF2B; Species: soybean, Glycine max. BF T01080; GBF3; Species: thale cress, Arabidopsis thaliana. BF T02670; GBF4; Species: tomato, Lycopersicon esculentum. BF T02673; GBF4; Species: thale cress, Arabidopsis thaliana. BF T02671; GBF9; Species: tomato, Lycopersicon esculentum. BF T00321; GCN4; Species: yeast, Saccharomyces cerevisiae. BF T02801; GSBF1; Species: rape, Brassica napus. BF T00328; Gt; Species: fruit fly, Drosophila melanogaster. BF T02039; HAC1; Species: yeast, Saccharomyces cerevisiae. BF T02781; HALF-1; Species: wheat, Triticum aestivum. BF T00354; HBP-1; Species: wheat, Triticum aestivum. BF T00937; HBP-1a; Species: wheat, Triticum aestivum. BF T01394; HBP-1a(1); Species: wheat, Triticum aestivum. BF T01395; HBP-1a(c14); Species: wheat, Triticum aestivum. BF T00938; HBP-1b; Species: wheat, Triticum aestivum. BF T01393; HBP-1b(c1); Species: wheat, Triticum aestivum. BF T01071; Hlf; Species: human, Homo sapiens. BF T02346; Hlf-alpha; Species: rat, Rattus norvegicus. BF T02348; Hlf-beta; Species: rat, Rattus norvegicus. BF T05026; HTF; Species: rat, Rattus norvegicus. BF T02812; HY5; Species: thale cress, Arabidopsis thaliana. BF T01319; ICER; Species: rat, Rattus norvegicus. BF T01321; ICER-I; Species: mouse, Mus musculus. BF T01322; ICER-Igamma; Species: mouse, Mus musculus. BF T01323; ICER-II; Species: mouse, Mus musculus. BF T02363; ICER-II; Species: human, Homo sapiens. BF T01324; ICER-IIgamma; Species: mouse, Mus musculus. BF T02364; ICER-IIgamma; Species: human, Homo sapiens. BF T00436; JunB; Species: mouse, Mus musculus. BF T01977; JunB; Species: human, Homo sapiens. BF T00437; JunD; Species: mouse, Mus musculus. BF T01978; JunD; Species: human, Homo sapiens. BF T02196; JunD; Species: chick, Gallus gallus. BF T02197; JunD; Species: rat, Rattus norvegicus. BF T01439; kreisler; Species: mouse, Mus musculus. BF T04866; LAF-4; Species: human, Homo sapiens. BF T01599; LCR-F1; Species: human, Homo sapiens. BF T04726; LebZIP1; Species: tomato, Lycopersicon esculentum. BF T02813; LG2; Species: maize, Zea mays. BF T04776; LIP; Species: Raphanus sativus, radish. BF T02803; LIP15; Species: maize, Zea mays. BF T02802; LIP19; Species: rice, Oryza sativa. BF T01433; MafB; Species: chick, Gallus gallus. BF T02202; MafB; Species: quail, Coturnix japonica. BF T01436; MafF; Species: chick, Gallus gallus. BF T01437; MafG; Species: chick, Gallus gallus. BF T04870; MafG; Species: human, Homo sapiens. BF T01434; MafK; Species: chick, Gallus domesticus. BF T01435; MafK; Species: mouse, Mus musculus. BF T04874; MafK; Species: human, Homo sapiens. BF T02309; MET28; Species: yeast, Saccharomyces cerevisiae. BF T02310; MET4; Species: yeast, Saccharomyces cerevisiae. BF T01440; NF-E2 p45; Species: human, Homo sapiens. BF T01441; NF-E2 p45; Species: mouse, Mus musculus. BF T00673; NRF-1; Species: human, Homo sapiens. BF T05126; NRF-1; Species: mouse, Mus musculus. BF T01442; Nrf1; Species: human, Homo sapiens. BF T02203; Nrf1; Species: mouse, Mus musculus. BF T01443; Nrf2; Species: human, Homo sapiens. BF T04938; Nrf2; Species: mouse, Mus musculus. BF T01082; NRL; Species: human, Homo sapiens. BF T01438; NRL; Species: mouse, Mus musculus. BF T02664; OBF-1; Species: maize, Zea mays. BF T02662; OBF3.1; Species: maize, Zea mays. BF T02663; OBF3.2; Species: maize, Zea mays. BF T02659; OBF4; Species: thale cress, Arabidopsis thaliana. BF T02661; OBF5; Species: thale cress, Arabidopsis thaliana. BF T02999; OCSBF-1; Species: maize, Zea mays. BF T02721; OHP1; Species: maize, Zea mays. BF T02793; OHP2; Species: maize, Zea mays. BF T00668; Opaque-2; Species: maize, Zea mays. BF T02780; Opaque-2; Species: Job's-tears, Coix lacryma-jobi. BF T02788; Opaque-2; Species: Sorghum bicolor. BF T02807; OSBZ8; Species: rice, Oryza sativa. BF T00676; pap1; Species: fission yeast, Schizosaccharomyces pombe. BF T01687; pcr1; Species: fission yeast, Schizosaccharomyces pombe. BF T02968; PERIANTHIA; Species: thale cress, Arabidopsis thaliana. BF T04856; PG13; Species: tobacco, Nicotiana tabacum. BF T02808; REB; Species: rice, Oryza sativa. BF T02811; RF2a; Species: rice, Oryza sativa. BF T04699; RISBZ1; Species: rice, Oryza sativa. BF T04704; RISBZ2; Species: rice, Oryza sativa. BF T04706; RISBZ3; Species: rice, Oryza sativa. BF T04702; RISBZ4; Species: rice, Oryza sativa. BF T04703; RISBZ5; Species: rice, Oryza sativa. BF T02786; RITA-1; Species: rice, Oryza sativa. BF T02809; ROM1; Species: french bean, Phaseolus vulgaris. BF T02810; ROM2; Species: french bean, Phaseolus vulgaris. BF T04547; RSG; Species: tobacco, Nicotiana tabacum. BF T01310; S-CREM; Species: mouse, Mus musculus. BF T01306; SKO1; Species: yeast, Saccharomyces cerevisiae. BF T02787; SPA; Species: wheat, Triticum aestivum. BF T02969; STF1; Species: soybean, Glycine max. BF T02973; STF2; Species: soybean, Glycine max. BF T01090; TAF-1; Species: tobacco, Nicotiana tabacum. BF T01072; TEF; Species: rat, Rattus norvegicus. BF T04876; TEF; Species: human, Homo sapiens. BF T02794; TGA1; Species: thale cress, Arabidopsis thaliana. BF T02975; TGA1; Species: soybean, Glycine max. BF T00829; TGA1a; Species: tobacco, Nicotiana tabacum. BF T00830; TGA1b; Species: tobacco, Nicotiana tabacum. BF T02795; TGA2; Species: thale cress, Arabidopsis thaliana. BF T04757; TGA2.1; Species: tobacco, Nicotiana tabacum. BF T04758; TGA2.2; Species: tobacco, Nicotiana tabacum. BF T02796; TGA3; Species: thale cress, Arabidopsis thaliana. BF T02797; TGA6; Species: thale cress, Arabidopsis thaliana. BF T04821; TRAB1; Species: rice, Oryza sativa. BF T00888; v-Fos; Species: FBR MuLV, FBR murine osteosarcoma virus. BF T01452; v-Fos; Species: FBJ MuLV, FBJ murine osteosarcoma virus. BF T01453; v-Fos; Species: NK24, avian retrovirus. BF T00893; v-Jun; Species: ASV, avian sarcoma virus. BF T01430; v-Maf; Species: AS42, avian musculoaponeurotic fibrosarcoma virus. BF T00881; VBP; Species: chick, Gallus gallus. BF T02976; VSF-1; Species: tomato, Lycopersicon esculentum. BF T00902; XBP-1; Species: human, Homo sapiens. BF T00028; YAP1; Species: yeast, Saccharomyces cerevisiae. BF T03712; YAP3; Species: yeast, Saccharomyces cerevisiae. BF T03713; YAP5; Species: yeast, Saccharomyces cerevisiae. BF T03714; YAP6; Species: yeast, Saccharomyces cerevisiae. BF T03715; YAP7; Species: yeast, Saccharomyces cerevisiae. BF T02804; ZIP-1A; Species: rice, Oryza sativa. BF T02805; ZIP-2A; Species: rice, Oryza sativa. BF T02806; ZIP-2B; Species: rice, Oryza sativa. BF T00923; Zta; Species: EBV, Epstein-Barr virus. XX DR Prosite: PS00036. XX RN [1] RX MEDLINE; 92154683. RA O'Shea E. K. Rutkowski R. Kim P. S. RT Mechanism of specificity in the Fos-Jun oncoprotein heterodimer RL Cell 68:699-708 (1992). RN [2] RX MEDLINE; 92011551. RA Matsuda S. Maekawa T. Ishii S. RT Identification of the functional domains of the transcriptional regulator RT CRE-BP1 RL J. Biol. Chem. 266:18188-18193 (1991). RN [3] RX MEDLINE; 91204424. RA Schuermann M. Hunter J. B. Henning G. Mueller R. RT Non-leucine residues in the leucine repeats of Fos and Jun contribute to RT the stability and determine the specificity of dimerization RL Nucleic Acids Res. 19:739-746 (1991). RN [4] RX MEDLINE; 92054531. RA O'Shea E. K. Klemm J. D. Kim P. S. Alber T. RT X-ray structure of the GCN4 leucine zipper, atwo-stranded, parallel coiled RT coil RL Science 254:539-544 (1991). RN [5] RX MEDLINE; 91015365. RA Patel L. Abate C. Curan T. RT Altered protein conformation on DNA binding by Fos and Jun RL Nature 347:572-574 (1990). RN [6] RX MEDLINE; 91015366. RA Weiss M. A. Ellenberger T. Wobbe C. R. Lee J. P. Harrison S. C. Struhl K. RT Folding transition in the DNA-binding domain of GCN4 on specific binding to RT DNA RL Nature 347:575-578 (1990). RN [7] RX MEDLINE; 90138931. RA Abate C. Luk D. Gentz R. Rauscher III F. J. Curran T. RT Expression and purification of the leucine zipper and DNA-binding domains RT of Fos and Jun: Both Fos and Jun contact DNA directly RL Proc. Natl. Acad. Sci. USA 87:1032-1036 (1990). RN [8] RX MEDLINE; 90251683. RA Nye J. A. Graves B. J. RT Alkylation interference identifies essential DNA contacts for RT sequence-specific binding of the eukaryotic transcription factor C/EBP RL Proc. Natl. Acad. Sci. USA 87:3992-3996 (1990). RN [9] RX MEDLINE; 91149345. RA Saudek V. Pastore A. Castiglione Morelli M. A. Frank R. Gausepohl H. Gibson RA T. Weih F. Roesch P. RT Solution structure of the DNA-binding domain of the yeast transcriptional RT activator protein GCN4 RL Protein Engineering 4:3-10 (1990). RN [10] RX MEDLINE; 90357025. RA Shuman J. D. Vinson C. R. McKnight S. L. RT Evidence of changes in protease sensitivity and subunit exchange rate on RT DNA binding by C/EBP RL Science 249:771-774 (1990). RN [11] RX MEDLINE; 89119572. RA Schuermann M. Neuberg M. Hunter J. B. Jenuwein T. Ryseck R.-P. Bravo R. RA Mueller R. RT The leucine repeat motif in Fos protein mediates complex formation with RT Jun/AP-1 and is required for transformation RL Cell 56:507-516 (1989). RN [12] RX MEDLINE; 89365144. RA Kouzarides T. Ziff E. RT Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and RT thereby control DNA binding RL Nature 340:568-571 (1989). RN [13] RX MEDLINE; 90049224. RA Vinson C. R. Sigler P. B. McKnight S. L. RT Scissors-grip model for DNA recognition by a family of leucine zipper RT proteins RL Science 246:911-916 (1989). RN [14] RX MEDLINE; 89186918. RA Gentz R. Rauscher III F. J. Abate C. Curan T. RT Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding RT domains RL Science 243:1695-1699 (1989). RN [15] RX MEDLINE; 89100305. RA O'Shea E. K. Rutkowski R. Kim P. S. RT Evidence that the leucine zipper is a coiled coil RL Science 243:538-542 (1989). RN [16] RX MEDLINE; 89346752. RA O'Shea E. K. Rutkowski R. Stafford III W. F. Kim P. S. RT Preferential heterodimer formation by isolated leucine zippers from Fos and RT Jun RL Science 245:646-648 (1989). RN [17] RX MEDLINE; 89051881. RA Halazonetis T. D. Georgopoulos K. Greenberg M. E. Leder P. RT c-jun dimerizes with itself and with c-Fos, forming complexes of different RT DNA binding affinities RL Cell 55:917-924 (1988). RN [18] RX MEDLINE; 88248716. RA Landschulz W. H. Johnson P. F. McKnight S. L. RT The leucine zipper: a hypothetical structure common to a new class of DNA RT binding proteins RL Science 240:1759-1764 (1988). XX // AC C0009 XX ID ZIP XX DT 25.09.1993 (created); ewi. DT 02.03.1995 (updated); dbo. CO Copyright (C), Biobase GmbH. XX CL leucine zipper XX CC A potential leucine zipper that is not preceded by a basic domain. The CC leucine zipper consists of repeated leucine residues at every seventh CC position and mediates protein dimerization as a prerequisite for CC DNA-binding. The leucines are directed towards one side of an alpha-helix. CC The leucine side chains of two polypeptides are thought to interdigitate CC upon dimerization (knobs-into-holes model). The leucine zipper may dictate CC dimerization specificity. XX BF T00096; CCBF; Species: yeast, Saccharomyces cerevisiae. BF T00320; GCF; Species: human, Homo sapiens. BF T00421; IREBF-1; Species: mouse, Mus musculus. BF T03471; KCS1; Species: yeast, Saccharomyces cerevisiae. BF T03501; MSN1; Species: yeast, Saccharomyces cerevisiae. BF T00775; SWI4; Species: yeast, Saccharomyces cerevisiae. BF T02034; swi4; Species: fission yeast, Schizosaccharomyces pombe. BF T01013; SWI6; Species: yeast, Saccharomyces cerevisiae. XX // AC C0010 XX ID bHLH XX DT 25.09.1993 (created); ewi. DT 02.03.1995 (updated); dbo. CO Copyright (C), Biobase GmbH. XX CL basic region + helix-loop-helix motif XX CC A DNA-binding basic region is followed by a motif of two potential CC amphipathic alpha-helices connected by a loop of variable length, possibly CC an omega loop. This putative helix-loop-helix (HLH) motif mediates CC dimerization as a prerequisite for DNA-binding. Upon dimerization, the CC alpha-helical content may significantly increase supporting the model of a CC four-helix bundle dimerization interface. Probably, the HLH domains of both CC dimer constituents are arranged in a parallel orientation. The basic region CC dictates DNA-binding specificity. Upon DNA-binding of the dimer, the basic CC regions adopt alpha-helical conformation as well. XX BF T04902; ABF-1; Species: human, Homo sapiens. BF T00005; Ac; Species: fruit fly, Drosophila melanogaster. BF T00018; AhR; Species: mouse, Mus musculus. BF T00019; AhR; Species: rat, Rattus norvegicus. BF T01795; AhR; Species: human, Homo sapiens. BF T02270; AhR; Species: guinea pig, Cavia sp. BF T01497; ALF1A; Species: mouse, Mus musculus. BF T01496; ALF1B; Species: mouse, Mus musculus. BF T04568; AN1; Species: Petunia hybrida. BF T01346; Arnt; Species: human, Homo sapiens. BF T01797; Arnt; Species: mouse, Mus musculus. BF T01798; Arnt; Species: rat, Rattus norvegicus. BF T01796; Arnt (774 AA form); Species: human, Homo sapiens. BF T05059; ARNT2; Species: human, Homo sapiens. BF T00003; AS-C T3; Species: fruit fly, Drosophila melanogaster. BF T00006; Ase; Species: fruit fly, Drosophila melanogaster. BF T01621; ASH-1; Species: clawed frog, Xenopus laevis. BF T01622; ASH-3a; Species: clawed frog, Xenopus laevis. BF T01623; ASH-3b; Species: clawed frog, Xenopus laevis. BF T01628; Ato; Species: fruit fly, Drosophila melanogaster. BF T01668; Atoh1; Species: mouse, Mus musculus. BF T04544; ATOH1; Species: human, Homo sapiens. BF T04545; Atoh1; Species: chick, Gallus gallus. BF T01629; Atoh2; Species: mouse, Mus musculus. BF T01792; BETA1; Species: hamster, Cricetulus griseus. BF T01634; BETA2; Species: hamster. BF T01674; BETA3; Species: hamster. BF T00080; CBF1; Species: yeast, Saccharomyces cerevisiae. BF T04891; CLOCK; Species: human, Homo sapiens. BF T01653; Delilah; Species: fruit fly, Drosophila melanogaster. BF T02404; Dermo-1; Species: mouse, Mus musculus. BF T01647; Dpn; Species: fruit fly, Drosophila melanogaster. BF T01644; E(spl)m5; Species: fruit fly, Drosophila melanogaster. BF T01645; E(spl)m7; Species: fruit fly, Drosophila melanogaster. BF T01646; E(spl)m8; Species: fruit fly, Drosophila melanogaster. BF T00204; E12; Species: human, Homo sapiens. BF T00675; E12; Species: rat, Rattus norvegicus. BF T01786; E12; Species: mouse, Mus musculus. BF T01787; E12; Species: clawed frog, Xenopus laevis. BF T00207; E47; Species: human, Homo sapiens. BF T00674; E47; Species: rat, Rattus norvegicus. BF T01788; E47; Species: mouse, Mus musculus. BF T01637; EC2; Species: human, Homo sapiens. BF T01638; EC2; Species: mouse, Mus musculus. BF T02718; EPAS1; Species: human, Homo sapiens. BF T02719; EPAS1; Species: mouse, Mus musculus. BF T04912; Epicardin; Species: human, Homo sapiens. BF T01541; esc1; Species: fission yeast, Schizosaccharomyces pombe. BF T01793; GE1; Species: chick, Gallus gallus. BF T00345; H; Species: fruit fly, Drosophila melanogaster. BF T01643; H; Species: fruit fly, Drosophila virilis. BF T01569; Hand1; Species: mouse, Mus musculus. BF T04371; Hand1; Species: chick, Gallus gallus. BF T04373; HAND1; Species: human, Homo sapiens. BF T04375; Hand1; Species: rat, Rattus norvegicus. BF T04380; Hand1; Species: rabbit, Oryctolagus cuniculus. BF T04381; Hand1; Species: clawed frog, Xenopus laevis. BF T04385; Hand1; Species: sheep, Ovis aries. BF T04370; Hand2; Species: mouse, Mus musculus. BF T04372; Hand2; Species: chick, Gallus gallus. BF T04374; HAND2; Species: human, Homo sapiens. BF T04387; Hand2; Species: clawed frog, Xenopus laevis. BF T04388; Hand2; Species: zebra fish, Brachydanio rerio. BF T01503; HEB; Species: human, Homo sapiens. BF T01447; HEN1; Species: rat, Rattus norvegicus. BF T01654; HEN1; Species: human, Homo sapiens. BF T01655; HEN1; Species: mouse, Mus musculus. BF T01656; HEN2; Species: human, Homo sapiens. BF T01657; HEN2; Species: mouse, Mus musculus. BF T01648; HES-1; Species: rat, Rattus norvegicus. BF T01649; HES-1; Species: mouse, Mus musculus. BF T01650; HES-2; Species: rat, Rattus norvegicus. BF T05078; HES-2; Species: mouse, Mus musculus. BF T01651; HES-3; Species: rat, Rattus norvegicus. BF T05081; HES-3; Species: mouse, Mus musculus. BF T01652; HES-5; Species: rat, Rattus norvegicus. BF T05077; Hey1; Species: mouse, Mus musculus. BF T05085; Hey1; Species: human, Homo sapiens. BF T05083; Hey2; Species: mouse, Mus musculus. BF T05084; Hey2; Species: human, Homo sapiens. BF T05082; HeyL; Species: mouse, Mus musculus. BF T05086; HeyL; Species: human, Homo sapiens. BF T04491; HFR1; Species: thale cress, Arabidopsis thaliana. BF T01610; HIF-1alpha; Species: human, Homo sapiens. BF T00110; hlh-1; Species: Caenorhabditis elegans. BF T04892; HRY; Species: human, Homo sapiens. BF T04465; IB1; Species: human, Homo sapiens. BF T04466; IB1; Species: rat, Rattus norvegicus. BF T00405; IEBP1; Species: rat, Rattus norvegicus. BF T04569; IN1; Species: maize, Zea mays. BF T01241; INO2; Species: yeast, Saccharomyces cerevisiae. BF T01639; INO4; Species: yeast, Saccharomyces cerevisiae. BF T00406; INSAF; Species: hamster. BF T01188; INSAF; Species: rat, Rattus norvegicus. BF T01189; INSAF; Species: mouse, Mus musculus. BF T01794; INSAF; Species: human, Homo sapiens. BF T00432; ITF-1; Species: human, Homo sapiens. BF T00433; ITF-2; Species: human, Homo sapiens. BF T04571; JAF13; Species: Petunia hybrida. BF T04468; JIP1; Species: mouse, Mus musculus. BF T00463; LC; Species: maize, Zea mays. BF T01627; lin-32; Species: Caenorhabditis elegans. BF T01632; Lyl-1; Species: human, Homo sapiens. BF T01633; Lyl-1; Species: mouse, Mus musculus. BF T01635; M-Twist; Species: mouse, Mus musculus. BF T01659; m3; Species: mouse, Mus musculus. BF T00484; MASH-1; Species: rat, Rattus norvegicus. BF T01619; MASH-1; Species: mouse, Mus musculus. BF T01620; MASH-1; Species: human, Homo sapiens. BF T00485; MASH-2; Species: rat, Rattus norvegicus. BF T00506; MEF1; Species: mouse, Mus musculus. BF T01612; Meso1; Species: hamster. BF T02720; MOP3; Species: human, Homo sapiens. BF T00512; MRF4; Species: rat, Rattus norvegicus. BF T01537; MRF4; Species: mouse, Mus musculus. BF T01538; MRF4; Species: chick, Gallus gallus. BF T01539; MRF4; Species: clawed frog, Xenopus. BF T04572; MYC1; Species: Gerbera hybrida. BF T04786; MYC1; Species: thale cress, Arabidopsis thaliana. BF T00519; Myf-3; Species: human, Homo sapiens. BF T00520; Myf-4; Species: human, Homo sapiens. BF T00521; Myf-5; Species: human, Homo sapiens. BF T00949; Myf-5; Species: clawed frog, Xenopus laevis. BF T01534; Myf-5; Species: mouse, Mus musculus. BF T01535; Myf-5; Species: cattle, Bos taurus. BF T01536; Myf-5; Species: chick, Gallus domesticus. BF T03903; myf-5; Species: Common carp, Cyprinus carpio. BF T03905; myf-5; Species: zebra fish, Brachydanio rerio. BF T00522; Myf-6; Species: human, Homo sapiens. BF T00524; MyoD; Species: clawed frog, Xenopus laevis. BF T00525; MyoD; Species: human, Homo sapiens. BF T00526; MyoD; Species: mouse, Mus musculus. BF T01551; MyoD; Species: quail, Coturnix coturnix. BF T03902; MyoD; Species: Common carp, Cyprinus carpio. BF T03907; myoD; Species: zebra fish, Brachydanio rerio. BF T03912; myoD (275 AA); Species: rainbow trout, Oncorhynchus mykiss. BF T03911; myoD (376 AA); Species: rainbow trout, Oncorhynchus mykiss. BF T00528; myogenin; Species: mouse, Mus musculus. BF T01531; myogenin; Species: chick, Gallus gallus. BF T01532; myogenin; Species: rat, Rattus norvegicus. BF T01533; myogenin; Species: quail, Coturnix coturnix. BF T03900; myogenin; Species: Common carp, Cyprinus carpio. BF T03901; myogenin; Species: rainbow trout, Oncorhynchus mykiss. BF T01540; Nau; Species: fruit fly, Drosophila melanogaster. BF T01624; NeuroD; Species: Caenorhabditis elegans. BF T01625; NeuroD; Species: clawed frog, Xenopus laevis. BF T01626; NeuroD; Species: mouse, Mus musculus. BF T04903; NEUROD-2; Species: human, Homo sapiens. BF T04907; NEUROD-3; Species: human, Homo sapiens. BF T04546; NeuroD1; Species: human, Homo sapiens. BF T04908; NPAS1; Species: human, Homo sapiens. BF T04909; NPAS2; Species: human, Homo sapiens. BF T01642; NUC-1; Species: Neurospora crassa. BF T01613; Paraxis; Species: mouse, Mus musculus. BF T01288; PHD1; Species: yeast, Saccharomyces cerevisiae. BF T00690; PHO4; Species: yeast, Saccharomyces cerevisiae. BF T04492; PIF3; Species: thale cress, Arabidopsis thaliana. BF T04573; Ra; Species: rice, Oryza sativa. BF T04624; REP1; Species: thale cress, Arabidopsis thaliana. BF T00004; Sc; Species: fruit fly, Drosophila melanogaster. BF T01790; SCBPalpha; Species: rat, Rattus norvegicus. BF T01791; SCBPbeta; Species: rat, Rattus norvegicus. BF T01789; SCBPgamma; Species: rat, Rattus norvegicus. BF T01605; SGC1; Species: yeast, Saccharomyces cerevisiae. BF T00750; Sim; Species: fruit fly, Drosophila melanogaster. BF T03729; SIM1; Species: human, Homo sapiens. BF T04910; SIM2; Species: human, Homo sapiens. BF T03616; SOK2; Species: yeast, Saccharomyces cerevisiae. BF T02327; Stra13; Species: mouse, Mus musculus. BF T02248; StuAp; Species: Aspergillus nidulans, Emericella nidulans. BF T00926; SUM-1; Species: sea urchin, Lytechinus variegatus. BF T00790; Tal-1; Species: human, Homo sapiens. BF T01799; Tal-1; Species: mouse, Mus musculus. BF T01800; Tal-1; Species: chick, Gallus gallus. BF T01448; Tal-1beta; Species: human, Homo sapiens. BF T01630; Tal-2; Species: human, Homo sapiens. BF T01631; Tal-2; Species: mouse, Mus musculus. BF T04591; TT8; Species: thale cress, Arabidopsis thaliana. BF T01517; Twi; Species: fruit fly, Drosophila melanogaster. BF T04913; TWIST; Species: human, Homo sapiens. BF T00871; USF; Species: sea urchin, Strongylocentrotus purpuratus. BF T01636; X-Twist; Species: clawed frog, Xenopus. XX DR Prosite: PS00038. XX RN [1] RX MEDLINE; 92188160. RA Anthony-Cahill S. J. Benfield P. A. Fairman R. Wasserman Z. R. Brenner S. RA L. Stafford III W. F. Altenbach C. Hubbell W. L. DeGrado W. F. RT Molecular characterization of helix-loop-helix peptides RL Science 255:979-983 (1992). RN [2] RX MEDLINE; 91102564. RA Prendergast G. C. Ziff E. B. RT Methylation-sensitive sequence-specific DNA binding by the c-Myc basic RT region RL Science 251:186-189 (1991). RN [3] RX MEDLINE; 90359487. RA Collum R. G. Alt F. W. RT Are myc proteins transcription factors RL Cancer Cells 2:69-75 (1990). RN [4] RX MEDLINE; 91099653. RA Luescher B. Eisenman R. N. RT New light on Myc and Myb. Part I. Myc RL Genes Dev. 4:2025-2035 (1990). RN [5] RX MEDLINE; 90280447. RA Voronova A. Baltimore D. RT Mutations that disrupt DNA binding and dimer formation in the E47 RT helix-loop-helix protein map to distinct domains RL Proc. Natl. Acad. Sci. USA 87:4722-4726 (1990). RN [6] RX MEDLINE; 89168418. RA Murre C. McCaw P. S. Baltimore D. RT A new DNA binding and dimerization motif in immunoglobulin enhancer RT binding, daughterless, MyoD, and myc proteins RL Cell 56:777-783 (1989). RN [7] RX MEDLINE; 87042772. RA Leszczynski J. F. Rose G. D. RT Loops in globular proteins: a novel category of secondary structure RL Science 234:849-855 (1986). XX // AC C0011 XX ID HLH XX DT 25.09.1993 (created); ewi. DT 02.03.1995 (updated); dbo. CO Copyright (C), Biobase GmbH. XX CL helix-loop-helix motif XX CC Two potential amphipathic alpha-helices are connected by a loop of variable CC length, possibly an omega loop. This putative helix-loop-helix (HLH) motif CC mediates dimerization. Upon dimerization, the alpha-helical content may CC significantly increase supporting the model of a four-helix bundle CC dimerization interface. Probably, the HLH domains of both dimer CC constituents are arranged in a parallel orientation. XX BF T04779; CBF-C; Species: thale cress, Arabidopsis thaliana. BF T01112; COE1; Species: mouse, Mus musculus. BF T05006; COE2; Species: mouse, Mus musculus. BF T05008; COE3; Species: mouse, Mus musculus. BF T05041; COL-1; Species: fruit fly, Drosophila melanogaster. BF T05055; COL-2; Species: fruit fly, Drosophila melanogaster. BF T00274; Emc; Species: fruit fly, Drosophila melanogaster. BF T00403; Id1; Species: mouse, Mus musculus. BF T01801; Id1; Species: human, Homo sapiens. BF T01807; Id1; Species: rat, Rattus norvegicus. BF T01606; Id1.25; Species: rat, Rattus norvegicus. BF T02274; Id1H'; Species: human, Homo sapiens. BF T00404; Id2; Species: mouse, Mus musculus. BF T01212; Id2; Species: human, Homo sapiens. BF T01808; Id2; Species: rat, Rattus norvegicus. BF T00367; Id3; Species: mouse, Mus musculus. BF T01809; Id3; Species: human, Homo sapiens. BF T01811; Id3; Species: rat, Rattus norvegicus. BF T01810; Id3 / Heir-1; Species: human, Homo sapiens. BF T01658; Id4; Species: mouse, Mus musculus. BF T01040; Olf-1; Species: rat, Rattus norvegicus. XX DR Prosite: PS00038. XX // AC C0012 XX ID bHLH-ZIP XX DT 25.09.1993 (created); ewi. DT 02.03.1995 (updated); dbo. CO Copyright (C), Biobase GmbH. XX CL basic region + helix-loop-helix motif + leucine zipper XX CC A DNA-binding basic region is followed by a motif of two potential CC amphipathic alpha-helices connected by a loop of variable length, possibly CC an omega loop, and a leucine zipper motif. The putative helix-loop-helix CC (HLH) motif mediates dimerization as a prerequisite for DNA-binding. Upon CC dimerization, the alpha-helical content may significantly increase CC supporting the model of a four-helix bundle dimerization interface. CC Probably, the HLH domains of both dimer constituents are arranged in a CC parallel orientation. The basic region dictates DNA-binding specificity. CC Upon DNA-binding of the dimer, the basic regions adopt alpha-helical CC conformation as well. The leucine zipper consists of repeated leucine CC residues at every seventh position. The leucines are directed towards one CC side of an alpha-helix. The leucine side chains of two polypeptides are CC thought to interdigitate upon dimerization. The leucine zipper of bHLH-ZIP CC proteins may be involved in protein dimerization reactions as well. XX BF T00036; AP-4; Species: human, Homo sapiens. BF T01563; B-Myc; Species: rat, Rattus norvegicus. BF T02916; B-Peru; Species: maize, Zea mays. BF T00140; c-Myc; Species: human, Homo sapiens. BF T00141; c-Myc; Species: chick, Gallus gallus. BF T00142; c-Myc; Species: rat, Rattus norvegicus. BF T00143; c-Myc; Species: mouse, Mus musculus. BF T03427; c-Myc; Species: Chimpanzee, Pan troglodytes. BF T03428; c-Myc; Species: woodchuck, Marmota monax. BF T03430; c-Myc; Species: gibbon ape, Hylobates lar. BF T03432; c-Myc; Species: dog, Canis familiaris. BF T03433; c-Myc; Species: Common marmoset, Callithrix jacchus. BF T03450; c-Myc; Species: zebra fish, Brachydanio rerio. BF T03454; c-Myc; Species: goldfish, Carassius auratus. BF T03455; c-Myc; Species: sheep, Ovis aries. BF T03462; c-Myc; Species: rainbow trout, Oncorhynchus mykiss. BF T03463; c-Myc; Species: Northern sea star, Asterias vulgaris. BF T03466; c-Myc; Species: wild cat, Felis silvestris. BF T03532; c-Myc; Species: domestic pig, Sus scrofa. BF T03537; c-Myc; Species: canary, Serinus canaria. BF T03341; C-Myc 1; Species: human, Homo sapiens. BF T03459; c-Myc I; Species: Common carp, Cyprinus carpio. BF T03464; c-Myc I; Species: clawed frog, Xenopus laevis. BF T03460; c-Myc II; Species: Common carp, Cyprinus carpio. BF T03465; c-Myc II; Species: clawed frog, Xenopus laevis. BF T01034; Da; Species: fruit fly, Drosophila melanogaster. BF T02957; del (delila); Species: garden snapdragon, Antirrhinum majus. BF T01566; deltaMax; Species: human, Homo sapiens. BF T02388; L-Myc-1; Species: clawed frog, Xenopus laevis. BF T02385; L-Myc-1(long form); Species: human, Homo sapiens. BF T02389; L-Myc-2; Species: clawed frog, Xenopus laevis. BF T03539; L-Myc-2; Species: human, Homo sapiens. BF T02387; L-Myc1; Species: mouse, Mus musculus. BF T01565; Mad1; Species: human, Homo sapiens. BF T02390; Mad1; Species: mouse, Mus musculus. BF T02391; Mad3; Species: mouse, Mus musculus. BF T02392; Mad4; Species: mouse, Mus musculus. BF T00523; Max; Species: mouse, Mus musculus. BF T03552; Max; Species: zebra fish, Brachydanio rerio. BF T03570; Max; Species: chick, Gallus gallus. BF T03592; Max; Species: fruit fly, Drosophila melanogaster. BF T03595; Max; Species: rat, Rattus norvegicus. BF T03596; Max; Species: clawed frog, Xenopus laevis. BF T05056; Max; Species: human, Homo sapiens. BF T00489; Max1; Species: human, Homo sapiens. BF T01567; Max2; Species: human, Homo sapiens. BF T03940; Mga; Species: mouse, Mus musculus. BF T01553; MITF; Species: human, Homo sapiens. BF T01554; Mitf; Species: mouse, Mus musculus. BF T05060; MLX; Species: human, Homo sapiens. BF T05123; MLX; Species: mouse, Mus musculus. BF T05124; MondoA; Species: human, Homo sapiens. BF T05125; MondoA; Species: mouse, Mus musculus. BF T01564; Mxi1; Species: human, Homo sapiens. BF T03936; Myc; Species: fruit fly, Drosophila melanogaster. BF T03006; MYC-RP; Species: Perilla frutescens. BF T01445; N-Myc; Species: mouse, Mus musculus. BF T02379; N-Myc; Species: human, Homo sapiens. BF T02381; N-Myc; Species: canary, Serinus canaria. BF T02382; N-Myc; Species: chick, Gallus gallus. BF T02383; N-Myc; Species: clawed frog, Xenopus laevis. BF T03442; N-Myc; Species: rat, Rattus norvegicus. BF T03440; N-Myc1; Species: woodchuck, Marmota monax. BF T03443; N-Myc2; Species: woodchuck, Marmota monax. BF T03457; N-Myc2; Species: Beechey ground squirrel, Spermophilus beecheyi. BF T03268; Rox; Species: human, Homo sapiens. BF T03269; Rox; Species: mouse, Mus musculus. BF T03577; RTG1; Species: yeast, Saccharomyces cerevisiae. BF T03579; RTG3; Species: yeast, Saccharomyces cerevisiae. BF T03550; S-Myc; Species: rat, Rattus norvegicus. BF T02954; SN (sienna); Species: maize, Zea mays. BF T04668; Spz1; Species: mouse, Mus musculus. BF T01559; SREBP-1; Species: hamster, Cricetulus griseus. BF T01562; SREBP-1; Species: rat, Rattus norvegicus. BF T04556; SREBP-1; Species: rabbit, Oryctolagus cuniculus. BF T04562; SREBP-1; Species: mouse, Mus musculus. BF T04563; SREBP-1; Species: domestic pig, Sus scrofa. BF T04584; SREBP-1; Species: chick, Gallus gallus. BF T01556; SREBP-1a; Species: human, Homo sapiens. BF T01557; SREBP-1b; Species: human, Homo sapiens. BF T01558; SREBP-1c; Species: human, Homo sapiens. BF T01560; SREBP-2; Species: human, Homo sapiens. BF T01561; SREBP-2; Species: hamster, Cricetulus griseus. BF T04553; SREBP-2; Species: chick, Gallus gallus. BF T04564; SREBP-2; Species: rabbit, Oryctolagus cuniculus. BF T04567; SREBP-2; Species: Pig, Sus scrofa. BF T00811; TFE3; Species: human, Homo sapiens. BF T00810; TFE3-L; Species: mouse, Mus musculus. BF T00814; TFE3-S; Species: mouse, Mus musculus. BF T00812; TFEB; Species: human, Homo sapiens. BF T01552; TFEC; Species: rat, Rattus norvegicus. BF T00875; USF-1; Species: rat, Rattus norvegicus. BF T00877; USF-1; Species: mouse, Mus musculus. BF T02378; USF-1; Species: Kenyan clawed frog, Xenopus borealis. BF T00874; USF1; Species: human, Homo sapiens. BF T00878; USF2; Species: human, Homo sapiens. BF T01555; USF2; Species: mouse, Mus musculus. BF T02115; USF2; Species: rat, Rattus norvegicus. BF T02377; USF2b; Species: human, Homo sapiens. BF T00896; v-Myc; Species: MC29, avian myelocytomatosis virus. BF T03533; v-Myc; Species: Avian myelocytomatosis virus CMII. BF T03535; v-Myc; Species: Feline leukemia provirus FTT. BF T03540; v-Myc; Species: Avian myelocytomatosis virus MC29. BF T03546; v-Myc; Species: HBI, avian myelocytomatosis virus. BF T03547; v-Myc; Species: MH2E21, avian retrovirus. BF T03548; v-Myc; Species: OK10, avian retrovirus. BF T05121; WBSCR14; Species: human, Homo sapiens. BF T05122; WBSCR14; Species: mouse, Mus musculus. XX DR Prosite: PS00038. XX RN [1] RX MEDLINE; 91208676. RA Prendergast G. C. Lawe D. Ziff E. B. RT Association of Myn, the murine homolog of Max, with c-Myc stimulates RT methylation-sensitive DNA binding and ras cotransformation RL Cell 65:395-407 (1991). RN [2] RX MEDLINE; 91117263. RA Dang C. V. Barrett J. Villa-Garcia M. Resar L. M. S. Kato G. J. Fearon E. R. RT Intracellular leucine zipper interactions suggest c-Myc RT hetero-oligomerization RL Mol. Cell. Biol. 11:954-962 (1991). RN [3] RX MEDLINE; 91172219. RA Yang B.-S. Geddes T. J. Pogulis R. J. de Crombrugghe B. Freytag S. O. RT Transcriptional suppression of cellular gene expression by c-Myc RL Mol. Cell. Biol. 11:2291-2295 (1991). RN [4] RX MEDLINE; 91173288. RA Blackwood E. M. Eisenman R. N. RT Max: a helix-loop-helix zipper protein that forms a sequence-specific RT DNA-binding complex with Myc RL Science 251:1211-1217 (1991). RN [5] RX MEDLINE; 91102564. RA Prendergast G. C. Ziff E. B. RT Methylation-sensitive sequence-specific DNA binding by the c-Myc basic RT region RL Science 251:186-189 (1991). RN [6] RX MEDLINE; 90359487. RA Collum R. G. Alt F. W. RT Are myc proteins transcription factors RL Cancer Cells 2:69-75 (1990). RN [7] RX MEDLINE; 90249724. RA Beckmann H. Su L.-K. Kadesch T. RT TFE3: a helix-loop-helix protein that activates transcription through the RT immunoglobulin enhancer E3 motif RL Genes Dev. 4:167-179 (1990). RN [8] RX MEDLINE; 91065519. RA Gregor P. D. Sawadogo M. Roeder R. G. RT The adenovirus major late transcription factor USF is a member of the RT helix-loop-helix group of regulatory proteins and binds to DNA as a dimer RL Genes Dev. 4:1730-1740 (1990). RN [9] RX MEDLINE; 91099653. RA Luescher B. Eisenman R. N. RT New light on Myc and Myb. Part I. Myc RL Genes Dev. 4:2025-2035 (1990). RN [10] RX MEDLINE; 90377223. RA Smith M. J. Charron-Prochownik D. C. Prochownik E. V. RT The leucine zipper of c-Myc is required for full inhibition of RT erythroleukemia differentiation RL Mol. Cell. Biol. 10:5333-5339 (1990). RN [11] RX MEDLINE; 90280447. RA Voronova A. Baltimore D. RT Mutations that disrupt DNA binding and dimer formation in the E47 RT helix-loop-helix protein map to distinct domains RL Proc. Natl. Acad. Sci. USA 87:4722-4726 (1990). RN [12] RX MEDLINE; 89168418. RA Murre C. McCaw P. S. Baltimore D. RT A new DNA binding and dimerization motif in immunoglobulin enhancer RT binding, daughterless, MyoD, and myc proteins RL Cell 56:777-783 (1989). RN [13] RX MEDLINE; 89143727. RA Dang C. V. McGuire M. Buckmire M. Lee W. M. F. RT Involvement of the 'leucine zipper' region in the oligomerization and RT transforming activity of human c-myc protein RL Nature 337:664-666 (1989). RN [14] RX MEDLINE; 87042772. RA Leszczynski J. F. Rose G. D. RT Loops in globular proteins: a novel category of secondary structure RL Science 234:849-855 (1986). XX // AC C0013 XX ID HLH-ZIP XX DT 25.09.1993 (created); ewi. DT 02.03.1995 (updated); dbo. CO Copyright (C), Biobase GmbH. XX CL helix-loop-helix motif + leucine zipper XX CC The molecule contains a motif of two potential amphipathic alpha-helices CC connected by a loop of variable length, possibly an omega loop, and a CC leucine zipper motif, but no basic domain. The putative helix-loop-helix CC (HLH) motif mediates dimerization as a prerequisite for DNA-binding. Upon CC dimerization, the alpha-helical content may significantly increase CC supporting the model of a four-helix bundle dimerization interface. CC Probably, the HLH domains of both dimer constituents are arranged in a CC parallel orientation. The leucine zipper consists of repeated leucine CC residues at every seventh position. The leucines are directed towards one CC side of an alpha-helix. The leucine side chains of two polypeptides are CC thought to interdigitate upon dimerization. The leucine zipper of HLH-ZIP CC proteins may be involved in protein dimerization reactions as well. XX BF T00880; Vav; Species: human, Homo sapiens. BF T01230; Vav; Species: mouse, Mus musculus. XX DR Prosite: PS00038. XX // AC C0014 XX ID MADS XX DT 25.09.1993 (created); ewi. DT 02.05.1996 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL MCM1-agamous-deficiens-SRF XX CC Proteins of this class comprise a region of homology. The DNA-binding CC domain also comprises the dimerization capability. In the DNA-bound dimer CC (shown for SRF), two antiparallel amphipathic alpha-helices (alpha-I), form CC a coiled coil and are oriented approximately parallel on the minor groove CC [1]. These helices make minor and major groove contacts, the N-terminal CC extensions form minor groove contacts [1]. The bound DNA is bent and CC wrapped around the protein. It exhibits a compressed minor groove in the CC center and widened minor groove in the flanks [1] XX BF T01007; AG; Species: thale cress, Arabidopsis thaliana. BF T01773; AG; Species: rape, Brassica napus. BF T03106; AG1; Species: tobacco, Nicotiana tabacum. BF T03191; AG1; Species: maize, Zea mays. BF T03192; AG2; Species: maize, Zea mays. BF T03193; AG3; Species: maize, Zea mays. BF T03009; AGL11; Species: thale cress, Arabidopsis thaliana. BF T03010; AGL12; Species: thale cress, Arabidopsis thaliana. BF T03011; AGL13; Species: thale cress, Arabidopsis thaliana. BF T03012; AGL14; Species: thale cress, Arabidopsis thaliana. BF T03018; AGL15; Species: thale cress, Arabidopsis thaliana. BF T03014; AGL15-1; Species: rape, Brassica napus. BF T03017; AGL15-2; Species: rape, Brassica napus. BF T03020; AGL17; Species: thale cress, Arabidopsis thaliana. BF T03024; AGL2; Species: thale cress, Arabidopsis thaliana. BF T04727; AGL20; Species: thale cress, Arabidopsis thaliana. BF T03025; AGL3; Species: thale cress, Arabidopsis thaliana. BF T03027; AGL4; Species: thale cress, Arabidopsis thaliana. BF T03029; AGL6; Species: thale cress, Arabidopsis thaliana. BF T03030; AGL8; Species: thale cress, Arabidopsis thaliana. BF T03032; AGL9; Species: thale cress, Arabidopsis thaliana. BF T01006; aMEF-2; Species: human, Homo sapiens. BF T03034; ANR1; Species: thale cress, Arabidopsis thaliana. BF T01775; AP1; Species: thale cress, Arabidopsis thaliana. BF T03036; AP1; Species: Cauliflower, Brassica oleracea var. botrytis. BF T03040; AP1-1; Species: broccoli, Brassica oleracea var. italica. BF T03042; AP1-2; Species: broccoli, Brassica oleracea var. italica. BF T01776; AP3; Species: thale cress, Arabidopsis thaliana. BF T03037; AP3; Species: Cauliflower, Brassica oleracea var. botrytis. BF T03100; AP3; Species: tomato, Lycopersicon esculentum. BF T03101; AP3; Species: Liriodendron tulipifera. BF T03104; AP3; Species: Michelia figo. BF T03127; AP3; Species: Peperomia hirta. BF T03163; AP3; Species: Ranunculus bulbosus. BF T03166; AP3; Species: Ranunculus ficaria. BF T03182; AP3; Species: common lilac, Syringa vulgaris. BF T03041; AP3-1; Species: broccoli, Brassica oleracea var. italica. BF T03138; AP3-1; Species: Papaver nudicaule. BF T03158; AP3-1; Species: Pachysandra terminalis. BF T03044; AP3-2; Species: broccoli, Brassica oleracea var. italica. BF T03139; AP3-2; Species: Papaver nudicaule. BF T03159; AP3-2; Species: Pachysandra terminalis. BF T03251; AP3/PI; Species: thale cress, Arabidopsis thaliana. BF T00043; ARG80; Species: yeast, Saccharomyces cerevisiae. BF T03035; ASMEF2; Species: sea squirt, Halocynthia roretzi. BF T04762; BM1; Species: barley, Hordeum vulgare. BF T04763; BM1-2; Species: barley, Hordeum vulgare. BF T04764; BM3; Species: barley, Hordeum vulgare. BF T04765; BM5; Species: barley, Hordeum vulgare. BF T04767; BM7; Species: barley, Hordeum vulgare. BF T04768; BM8; Species: barley, Hordeum vulgare. BF T04769; BM9; Species: barley, Hordeum vulgare. BF T03038; CAL; Species: Cauliflower, Brassica oleracea var. botrytis. BF T03039; CAL; Species: cabbage, Brassica oleracea. BF T03045; CAL; Species: broccoli, Brassica oleracea var. italica. BF T03049; CAL; Species: thale cress, Arabidopsis thaliana. BF T03060; CMB1; Species: Clove pink, Dianthus caryophyllus. BF T03061; CMB2; Species: Clove pink, Dianthus caryophyllus. BF T03062; CPPI; Species: Caltha palustris, Marsh marigold. BF T03063; CRM1; Species: Ceratopteris richardii. BF T03065; CRM2; Species: Ceratopteris pteridoides. BF T03067; CRM3; Species: Ceratopteris pteridoides. BF T03068; CRM4; Species: Ceratopteris pteridoides. BF T03069; CRM5; Species: Ceratopteris pteridoides. BF T03070; CRM6; Species: Ceratopteris pteridoides. BF T03071; CRM7; Species: Ceratopteris pteridoides. BF T03073; CUM1; Species: Cucumber, Cucumis sativus. BF T03072; CUM10; Species: Cucumber, Cucumis sativus. BF T03074; CUS1; Species: Cucumber, Cucumis sativus. BF T01772; D-MEF2; Species: fruit fly, Drosophila melanogaster. BF T03688; D-SRF; Species: fruit fly, Drosophila melanogaster. BF T03075; DAL1; Species: Norway spruce, Picea abies. BF T03076; DAL2; Species: Norway spruce, Picea abies. BF T03077; DAL3; Species: Norway spruce, Picea abies. BF T03078; DAPI; Species: Delphinium ajacis. BF T03808; Dd-SRF; Species: slime mould, Dictyostelium discoideum. BF T03079; DEAP3; Species: turkey corn, Dicentra eximia. BF T01008; DEF; Species: garden snapdragon, Antirrhinum majus. BF T03109; DEF; Species: tobacco, Nicotiana tabacum. BF T03179; DEF; Species: potato, Solanum tuberosum. BF T03216; DEF/GLO; Species: garden snapdragon, Antirrhinum majus. BF T03217; DEF/GLO/SQUA; Species: garden snapdragon, Antirrhinum majus. BF T03080; DEFH125; Species: garden snapdragon, Antirrhinum majus. BF T03081; DEFH200; Species: garden snapdragon, Antirrhinum majus. BF T03082; DEFH49; Species: garden snapdragon, Antirrhinum majus. BF T03083; DEFH72; Species: garden snapdragon, Antirrhinum majus. BF T03084; DEPI; Species: turkey corn, Dicentra eximia. BF T04609; DOMADS1; Species: Dendrobium grex Madame Thong-In. BF T04615; DOMADS2; Species: Dendrobium grex Madame Thong-In. BF T04616; DOMADS3; Species: Dendrobium grex Madame Thong-In. BF T03441; EAP1; Species: Eucalyptus grandis. BF T03444; EAP2L; Species: Eucalyptus grandis. BF T03445; EAP2S; Species: Eucalyptus grandis. BF T03085; EGM1; Species: Eucalyptus grandis. BF T03086; EGM2; Species: Eucalyptus grandis. BF T03087; EGM3; Species: Eucalyptus grandis. BF T03456; ETL; Species: Eucalyptus globulus subsp. globulus. BF T03208; FAR; Species: garden snapdragon, Antirrhinum majus. BF T03092; FBP1; Species: Petunia hybrida. BF T03091; FBP11; Species: Petunia hybrida. BF T03093; FBP2; Species: Petunia hybrida. BF T03094; FBP6; Species: Petunia hybrida. BF T03097; FBP7; Species: Petunia hybrida. BF T03287; FLC; Species: thale cress, Arabidopsis thaliana. BF T03284; FLF; Species: thale cress, Arabidopsis thaliana. BF T03099; GAG2; Species: Korean ginseng, Panax ginseng. BF T04587; GAGA1; Species: Gerbera hybrida. BF T04590; GAGA2; Species: Gerbera hybrida. BF T01778; GLO; Species: garden snapdragon, Antirrhinum majus. BF T01779; GLO; Species: tobacco, Nicotiana tabacum. BF T01777; GP; Species: Petunia hybrida. BF T04580; GRCD1; Species: Gerbera hybrida. BF T04740; JOINTLESS; Species: tomato, Lycopersicon esculentum. BF T03167; MADS A; Species: White mustard, Sinapis alba. BF T03168; MADS B; Species: White mustard, Sinapis alba. BF T03169; MADS C; Species: White mustard, Sinapis alba. BF T03170; MADS D; Species: White mustard, Sinapis alba. BF T03058; MADS1; Species: Ceratopteris richardii. BF T03103; MADS1; Species: Apple, Malus domestica. BF T03116; MADS1; Species: rice, Oryza sativa. BF T03132; MADS1; Species: Red pine, Pinus resinosa. BF T03146; MADS1; Species: Monterey pine, Pinus radiata. BF T03171; MADS1; Species: Sorghum bicolor. BF T03190; MADS1; Species: tobacco, Nicotiana tabacum. BF T03180; MADS11; Species: potato, Solanum tuberosum. BF T03181; MADS16; Species: potato, Solanum tuberosum. BF T03118; MADS2; Species: rice, Oryza sativa. BF T03134; MADS2; Species: Petunia hybrida. BF T03149; MADS2; Species: Monterey pine, Pinus radiata. BF T03172; MADS2; Species: Sorghum bicolor. BF T04707; MADS2; Species: Apple, Malus domestica. BF T03117; MADS24; Species: rice, Oryza sativa. BF T03046; MADS3; Species: White birch, Betula pendula. BF T03051; MADS3; Species: Ceratopteris richardii. BF T03119; MADS3; Species: rice, Oryza sativa. BF T03135; MADS3; Species: Petunia hybrida. BF T03150; MADS3; Species: Monterey pine, Pinus radiata. BF T04731; MADS3; Species: Apple, Malus domestica. BF T03047; MADS4; Species: White birch, Betula pendula. BF T03059; MADS4; Species: Ceratopteris richardii. BF T03121; MADS4; Species: rice, Oryza sativa. BF T03152; MADS4; Species: Monterey pine, Pinus radiata. BF T04732; MADS4; Species: Apple, Malus domestica. BF T03120; MADS45; Species: rice, Oryza sativa. BF T03048; MADS5; Species: White birch, Betula pendula. BF T03052; MADS5; Species: Ceratopteris richardii. BF T03122; MADS5; Species: rice, Oryza sativa. BF T03153; MADS5; Species: Monterey pine, Pinus radiata. BF T03154; MADS6; Species: Monterey pine, Pinus radiata. BF T03155; MADS7; Species: Monterey pine, Pinus radiata. BF T03156; MADS8; Species: Monterey pine, Pinus radiata. BF T03157; MADS9; Species: Monterey pine, Pinus radiata. BF T03819; map1; Species: fission yeast, Schizosaccharomyces pombe. BF T00500; MCM1; Species: yeast, Saccharomyces cerevisiae. BF T00505; MEF-2; Species: mouse, Mus musculus. BF T01005; MEF-2; Species: human, Homo sapiens. BF T03545; MEF-2; Species: Caenorhabditis elegans. BF T03581; MEF-2; Species: chick, Gallus gallus. BF T03895; MEF-2; Species:. BF T03763; MEF-2 (382 AA); Species: clawed frog, Xenopus laevis. BF T01784; MEF-2 (516 AA); Species: clawed frog, Xenopus laevis. BF T03759; MEF-2A; Species: Common carp, Cyprinus carpio. BF T03750; MEF-2A (460 AA); Species: zebra fish, Brachydanio rerio. BF T01012; MEF-2B; Species: human, Homo sapiens. BF T03896; MEF-2B; Species:. BF T01785; MEF-2B-1; Species: mouse, Mus musculus. BF T02501; MEF-2B-2; Species: mouse, Mus musculus. BF T02502; MEF-2B-3; Species: mouse, Mus musculus. BF T02503; MEF-2B-4; Species: mouse, Mus musculus. BF T01769; MEF-2C; Species: mouse, Mus musculus. BF T03761; MEF-2C; Species: Common carp, Cyprinus carpio. BF T03814; MEF-2C; Species: rat, Rattus norvegicus. BF T03897; MEF-2C; Species:. BF T02504; MEF-2C (433 AA form); Species: human, Homo sapiens. BF T03752; MEF-2C (449 AA); Species: zebra fish, Brachydanio rerio. BF T01766; MEF-2C (465 AA form); Species: human, Homo sapiens. BF T01767; MEF-2C (473 AA form); Species: human, Homo sapiens. BF T01768; MEF-2C/delta32 (441 AA form); Species: human, Homo sapiens. BF T01771; MEF-2D; Species: clawed frog, Xenopus laevis. BF T03753; MEF-2D; Species: zebra fish, Brachydanio rerio. BF T03821; MEF-2D; Species: quail, Coturnix japonica. BF T03822; MEF-2D; Species: rat, Rattus norvegicus. BF T03898; MEF-2D; Species:. BF T02506; MEF-2D (506 AA form); Species: mouse, Mus musculus. BF T02505; MEF-2D (514 AA form); Species: mouse, Mus musculus. BF T02511; MEF-2D00; Species: human, Homo sapiens. BF T02508; MEF-2D0B; Species: human, Homo sapiens. BF T02510; MEF-2DA'0; Species: human, Homo sapiens. BF T02507; MEF-2DA'B; Species: human, Homo sapiens. BF T02509; MEF-2DA0; Species: human, Homo sapiens. BF T01770; MEF-2DAB; Species: human, Homo sapiens. BF T01780; NMH7; Species: alfalfa, Medicago sativa. BF T03108; NMHC5; Species: alfalfa, Medicago sativa. BF T03114; OM1; Species: Aranda deborah. BF T03115; OPM1; Species: Ophioglossum pedunculosum. BF T00672; p67; Species: human, Homo sapiens. BF T03126; PAGL1; Species: Petunia integrifolia. BF T03102; PI; Species: Liriodendron tulipifera. BF T03128; PI; Species: Peperomia hirta. BF T03129; PI; Species: thale cress, Arabidopsis thaliana. BF T03183; PI; Species: common lilac, Syringa vulgaris. BF T03136; PI1; Species: Piper magnificum. BF T03141; PI1; Species: Papaver nudicaule. BF T03164; PI1; Species: Ranunculus bulbosus. BF T03137; PI2; Species: Piper magnificum. BF T03165; PI2; Species: Ranunculus bulbosus. BF T03130; PLE; Species: garden snapdragon, Antirrhinum majus. BF T03142; PNPI2; Species: Papaver nudicaule. BF T03145; POTM1-1; Species: potato, Solanum tuberosum. BF T04746; PTD; Species: cottonwood, Populus trichocarpa. BF T03160; RAD1; Species: garden sorrel, Rumex acetosa. BF T03161; RAD2; Species: garden sorrel, Rumex acetosa. BF T03162; RAP1; Species: garden sorrel, Rumex acetosa. BF T01783; RLM1; Species: yeast, Saccharomyces cerevisiae. BF T01009; RSRFC4; Species: human, Homo sapiens. BF T01010; RSRFC9; Species: human, Homo sapiens. BF T03022; SHP1; Species: thale cress, Arabidopsis thaliana. BF T03028; SHP2; Species: thale cress, Arabidopsis thaliana. BF T03173; SLM1; Species: Silene latifolia. BF T03174; SLM2; Species: Silene latifolia. BF T03175; SLM3; Species: Silene latifolia. BF T03176; SLM4; Species: Silene latifolia. BF T03177; SLM5; Species: Silene latifolia. BF T03601; SMP1; Species: yeast, Saccharomyces cerevisiae. BF T03178; SQUA; Species: garden snapdragon, Antirrhinum majus. BF T00761; SRF; Species: chick, Gallus gallus. BF T00762; SRF; Species: cat, Felis catus. BF T00763; SRF; Species: clawed frog, Xenopus laevis. BF T00764; SRF; Species: human, Homo sapiens. BF T00766; SRF; Species: rat, Rattus norvegicus. BF T03689; SRF; Species: Brugia Malayi. BF T03690; SRF; Species: zebra fish, Brachydanio rerio. BF T03693; SRF; Species: Brine shrimp, Artemia franciscana. BF T03806; SRF; Species: sponge, Geodia cydonium. BF T00765; SRF (504 AA); Species: mouse, Mus musculus. BF T03804; SRF (fragment); Species: Peacock butterfly, Junonia coenia. BF T03982; SRF-type; Species: fission yeast, Schizosaccharomyces pombe. BF T04631; SVP; Species: thale cress, Arabidopsis thaliana. BF T03184; TAG1; Species: tomato, Lycopersicon esculentum. BF T03185; TM3; Species: tomato, Lycopersicon esculentum. BF T03186; TM4; Species: tomato, Lycopersicon esculentum. BF T03187; TM5; Species: tomato, Lycopersicon esculentum. BF T03188; TM6; Species: tomato, Lycopersicon esculentum. BF T03189; TM8; Species: tomato, Lycopersicon esculentum. BF T01782; ZEM1; Species: maize, Zea mays. BF T01781; ZEM2/3; Species: maize, Zea mays. XX DR Prosite: PS00350. XX RN [1] RX MEDLINE; 95364921. RA Pellegrini L. Tan S. Richmond T. J. RT Structure of serum response factor core bound to DNA RL Nature 376:490-498 (1995). RN [2] RA Schwarz-Sommer Z. Huijser P. Nacken W. Saedler H. Sommer H. RT Genetic control of flower development by homeotic genes in Antirrhinum majus RL Science 250:931-936 (1990). XX // AC C0015 XX ID HMG XX DT 25.09.1993 (created); ewi. DT 16.10.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL high-mobility group protein-like factors XX CC Proteins of this class comprise a region of homology with the chromosomal CC non-histone HMG proteins such as HMG1. This region comprises the CC DNA-binding domain which in some instances such as HMG1 mediates CC sequence-unspecific, in other cases such LEF-1 sequence-specific binding to CC DNA. This domain exhibits a typical L-shaped conformation made up of 3 CC alpha-helices and an extended N-terminal extension of the first helix. The CC latter together with helix 1, which contains a kink, form the long arm of CC the L, whereas helices 1 and 2 form the short arm. Binding to the minor CC groove induces a sharp bending of the DNA by more than 90 degree, away from CC the bound protein. The overall topology of the DNA-protein complexes CC resembles somewhat that of the TBP-TATA box complex. XX BF T01274; ABF2; Species: yeast, Saccharomyces cerevisiae. BF T01848; Dm-SSRP1; Species: fruit fly, Drosophila melanogaster. BF T01850; DSP1; Species: fruit fly, Drosophila melanogaster. BF T00998; IRE-ABP; Species: rat, Rattus norvegicus. BF T01858; IRE-ABP; Species: mouse, Mus musculus. BF T01849; IXR1; Species: yeast, Saccharomyces cerevisiae. BF T00930; LEF-1; Species: mouse, Mus musculus. BF T02905; LEF-1; Species: human, Homo sapiens. BF T02953; LEF-1; Species: zebra fish, Brachydanio rerio. BF T02963; LEF-1; Species: clawed frog, Xenopus laevis. BF T03553; LEF-1; Species: chick, Gallus gallus. BF T03730; LEF-1; Species: rat, Rattus norvegicus. BF T03554; LEF-1B; Species: human, Homo sapiens. BF T01389; LEF-1S; Species: mouse, Mus musculus. BF T01275; mat1-Mc; Species: fission yeast, Schizosaccharomyces pombe. BF T01060; MNB1b; Species: maize, Zea mays, strain H84. BF T04602; NHP6A; Species: yeast, Saccharomyces cerevisiae. BF T04603; NHP6B; Species: yeast, Saccharomyces cerevisiae. BF T04784; PF1; Species: rice, Oryza sativa. BF T03244; pop-1; Species: Caenorhabditis elegans. BF T04386; prf1; Species: Ustilago maydis. BF T01286; ROX1; Species: yeast, Saccharomyces cerevisiae. BF T04918; SOX-10; Species: human, Homo sapiens. BF T02420; Sox-13; Species: mouse, Mus musculus. BF T04919; SOX-14; Species: human, Homo sapiens. BF T01843; Sox-18; Species: mouse, Mus musculus. BF T04920; SOX-18; Species: human, Homo sapiens. BF T01836; Sox-2; Species: mouse, Mus musculus. BF T01837; Sox-2; Species: chick, Gallus gallus. BF T04921; SOX-21; Species: human, Homo sapiens. BF T04916; SOX-3; Species: human, Homo sapiens. BF T01429; Sox-5; Species: mouse, Mus musculus. BF T01861; Sox-5; Species: human, Homo sapiens. BF T02897; SOX-6; Species: mouse, Mus musculus. BF T04917; SOX-8; Species: human, Homo sapiens. BF T01853; SOX-9; Species: human, Homo sapiens. BF T01854; SOX-9; Species: mouse, Mus musculus. BF T01844; Sox-LZ; Species: mouse, Mus musculus. BF T01845; Sox-LZ; Species: rainbow trout, Oncorhynchus mykiss. BF T02896; Sox15; Species: mouse, Mus musculus. BF T04855; SOX20; Species: human, Homo sapiens. BF T01276; SOX4; Species: human, Homo sapiens. BF T01838; Sox4; Species: mouse, Mus musculus. BF T00996; SRY; Species: mouse, Mus musculus. BF T00997; SRY; Species: human, Homo sapiens. BF T01986; SRY; Species: mouse, Mus domesticus Torino strain. BF T01987; SRY; Species: dunnart, Sminthopsis macroura. BF T02903; SRY; Species: gibbon ape, Hylobates lar. BF T01003; SSRP1; Species: human, Homo sapiens. BF T01855; SSRP1; Species: chick, Gallus gallus. BF T01856; SSRP1; Species: mouse, Mus musculus. BF T01857; SSRP1; Species: rat, Rattus norvegicus. BF T04843; SSRP1; Species: maize, Zea mays. BF T01422; ste11; Species: fission yeast, Schizosaccharomyces pombe. BF T02921; TCF; Species: chick, Gallus domesticus. BF T01002; TCF-1; Species: human, Homo sapiens. BF T01109; TCF-1(P); Species: mouse, Mus musculus. BF T00999; TCF-1A; Species: human, Homo sapiens. BF T00802; TCF-1alpha (old); Species: human, Homo sapiens. BF T01000; TCF-1B; Species: human, Homo sapiens. BF T02945; TCF-1B; Species: mouse, Mus musculus. BF T01001; TCF-1C; Species: human, Homo sapiens. BF T01846; TCF-1D; Species: human, Homo sapiens. BF T01979; TCF-1E; Species: human, Homo sapiens. BF T01981; TCF-1F; Species: human, Homo sapiens. BF T01982; TCF-1G; Species: human, Homo sapiens. BF T01111; TCF-3; Species: mouse, Mus musculus. BF T02857; TCF-3; Species: clawed frog, Xenopus laevis. BF T02877; TCF-3; Species: human, Homo sapiens. BF T02858; TCF-3B; Species: clawed frog, Xenopus laevis. BF T02861; TCF-3C; Species: clawed frog, Xenopus laevis. BF T02862; TCF-3D; Species: clawed frog, Xenopus laevis. BF T02915; TCF-4; Species: mouse, Mus musculus. BF T02918; TCF-4; Species: human, Homo sapiens. BF T03404; TCF-4; Species: clawed frog, Xenopus laevis. BF T03415; TCF-4(K); Species: mouse, Mus musculus. BF T03416; TCF-4(K); Species: human, Homo sapiens. BF T02913; TCF-4B; Species: mouse, Mus musculus. BF T02917; TCF-4B; Species: human, Homo sapiens. BF T02878; TCF-4E; Species: human, Homo sapiens. BF T02914; TCF-4E; Species: mouse, Mus musculus. BF T02922; TCF-A; Species: fruit fly, Drosophila melanogaster. BF T02924; TCF-B; Species: fruit fly, Drosophila melanogaster. BF T03748; TCF/ LEF; Species: sea urchin, Strongylocentrotus purpuratus. BF T03549; TCF/ LEF family; Species:. BF T03679; TFC3; Species: yeast, Saccharomyces cerevisiae. BF T02884; UBF; Species: clawed frog, Xenopus laevis. BF T02900; UBF; Species: human, Homo sapiens. BF T02902; UBF1; Species: clawed frog, Xenopus laevis. BF T02909; UBF1; Species: hamster, Cricetulus griseus. BF T02901; UBF2; Species: clawed frog, Xenopus laevis. BF T02910; UBF2; Species: hamster, Cricetulus griseus. XX // AC C0016 XX ID ETS XX DT 25.09.1993 (created); ewi. DT 02.03.1995 (updated); dbo. CO Copyright (C), Biobase GmbH. XX CL Factor family with homology to the ets-protooncogenes XX CC The ets-type DNA-binding domain of 85 amino acid residues encompasses three CC tryptophan residues in characteristic spacing (18-22) similar to the CC myb-like DNA-binding domain (tryptophan repeat). The last Trp residue is CC part of an adjacent basic region. There may be (at least) 7 subfamilies CC comprising Ets1+2, Erg, GABPalpha, PEA3, Elk, Elf and PU.1 factors. Ets CC domains exert strong major groove contacts to 10 nucleotides around GGA CC trinucleotide sequences. XX BF T04701; AP-2rep; Species: mouse, Mus musculus. BF T00111; c-Ets-1; Species: mouse, Mus musculus. BF T00112; c-Ets-1; Species: human, Homo sapiens. BF T05015; c-Ets-1; Species: rat, Rattus norvegicus. BF T00114; c-Ets-1 54; Species: chick, Gallus gallus. BF T00115; c-Ets-1 68; Species: chick, Gallus gallus. BF T02040; c-Ets-1A; Species: clawed frog, Xenopus laevis. BF T02123; c-Ets-1B; Species: clawed frog, Xenopus laevis. BF T00113; c-Ets-2; Species: human, Homo sapiens. BF T01397; c-Ets-2; Species: mouse, Mus musculus. BF T00116; c-Ets-2 58-64; Species: chick, Gallus gallus. BF T02041; c-Ets-2A; Species: clawed frog, Xenopus laevis. BF T02127; c-Ets-2B; Species: clawed frog, Xenopus laevis. BF T00208; E74A; Species: fruit fly, Drosophila melanogaster. BF T00210; E74B; Species: fruit fly, Drosophila melanogaster. BF T01113; ELF-1; Species: human, Homo sapiens. BF T05012; Elf-1; Species: mouse, Mus musculus. BF T05014; Elf-1; Species: rat, Rattus norvegicus. BF T05018; ELFR; Species: human, Homo sapiens. BF T02085; Elg; Species: fruit fly, Drosophila melanogaster. BF T00250; Elk-1; Species: human, Homo sapiens. BF T05013; Elk-1; Species: mouse, Mus musculus. BF T04885; ERF; Species: human, Homo sapiens. BF T00265; Erg-1; Species: human, Homo sapiens. BF T00266; Erg-2; Species: human, Homo sapiens. BF T01400; Ets-1 deltaVII; Species: human, Homo sapiens. BF T01408; Fli-1; Species: mouse, Mus musculus. BF T02066; Fli-1; Species: human, Homo sapiens. BF T02067; Fli-1; Species: clawed frog, Xenopus laevis. BF T00268; GABP; Species: human, Homo sapiens. BF T00298; GABP; Species: mouse, Mus musculus. BF T02095; GABP; Species: rat, Rattus norvegicus. BF T01390; GABP-alpha; Species: human, Homo sapiens. BF T01402; GABP-alpha; Species: mouse, Mus musculus. BF T04923; HSF4; Species: human, Homo sapiens. BF T03584; lin-1; Species: Caenorhabditis elegans. BF T05039; NERF; Species: human, Homo sapiens. BF T05021; NERF-1a; Species: human, Homo sapiens. BF T05022; NERF-1b; Species: human, Homo sapiens. BF T05023; NERF-2; Species: human, Homo sapiens. BF T01413; Net; Species: mouse, Mus musculus. BF T01414; Net; Species: human, Homo sapiens. BF T01409; p38erg; Species: human, Homo sapiens. BF T02130; p49erg; Species: human, Homo sapiens. BF T02129; p55erg; Species: human, Homo sapiens. BF T00684; PEA3; Species: mouse, Mus musculus. BF T01415; pointedP1; Species: fruit fly, Drosophila melanogaster. BF T01416; pointedP2; Species: fruit fly, Drosophila melanogaster. BF T00702; PU.1; Species: mouse, Mus musculus. BF T02068; PU.1; Species: human, Homo sapiens. BF T00737; SAP-1a; Species: human, Homo sapiens. BF T02128; SAP-1b; Species: human, Homo sapiens. BF T01401; Spi-B; Species: human, Homo sapiens. BF T00801; TCF; Species: human, Homo sapiens. BF T01399; TCF; Species: mouse, Mus musculus. BF T04998; Tel-2a; Species: human, Homo sapiens. BF T04886; Tel-2b; Species: human, Homo sapiens. BF T04999; Tel-2c; Species: human, Homo sapiens. BF T05000; Tel-2d; Species: human, Homo sapiens. BF T05001; Tel-2e; Species: human, Homo sapiens. BF T05002; Tel-2f; Species: human, Homo sapiens. BF T01417; TEL1; Species: human, Homo sapiens. BF T01398; v-Ets; Species: E26 AEV. BF T01396; yan; Species: fruit fly, Drosophila melanogaster. XX DR Prosite: PS00345, PS00346. XX RN [1] RX MEDLINE; 93145976. RA Wasylyk B. Hahn S. L. Giovane A. RT The Ets family of transcription factors RL Eur. J. Biochem. 211:7-18 (1993). RN [2] RX MEDLINE; 92275360. RA Wasylyk C. Kerckaert J.-P. Wasylyk B. RT A novel modulator domain of Ets transcription factors RL Genes Dev. 6:965-974 (1992). RN [3] RX MEDLINE; 92275361. RA Nye J. A. Petersen J. M. Gunther C. V. Jonsen M. D. Graves B. J. RT Interaction of murine Ets-1 with GGA-binding sites establishes the Ets RT domain as a new DNA-binding motif RL Genes Dev. 6:975-990 (1992). XX // AC C0017 XX ID paired XX DT 27.09.1993 (created); ewi. CO Copyright (C), Biobase GmbH. XX CL paired domain, paired box XX CC DNA-binding domain of approximately 130 amino acid residues. Its N-terminal CC half is basic, its C-terminal half highly charged in general. It probably CC comprises 3 alpha-helices XX BF T03205; egl-38; Species: Caenorhabditis elegans. BF T03206; egl-38 (233 AA); Species: Caenorhabditis elegans. BF T03210; K06B9.5; Species: Caenorhabditis elegans. BF T03209; K07C11.1; Species: Caenorhabditis elegans. BF T03211; NPX1; Species: Caenorhabditis elegans. BF T00398; Pax-1; Species: human, Homo sapiens. BF T00677; Pax-1; Species: mouse, Mus musculus. BF T02110; Pax-1; Species: chick, Gallus gallus. BF T03064; Pax-1/9; Species: sea squirt, Ciona intestinalis. BF T03066; Pax-1/9; Species: acorn worm, Ptychodera flava. BF T03050; Pax-1/9-I; Species: sea squirt, Halocynthia roretzi. BF T03053; Pax-1/9-II; Species: sea squirt, Halocynthia roretzi. BF T03054; Pax-1/9-III; Species: sea squirt, Halocynthia roretzi. BF T03055; Pax-1/9-IV; Species: sea squirt, Halocynthia roretzi. BF T03056; Pax-1/9-V; Species: sea squirt, Halocynthia roretzi. BF T03057; Pax-1/9-VI; Species: sea squirt, Halocynthia roretzi. BF T01823; Pax-2; Species: human, Homo sapiens. BF T03013; Pax-2; Species: chick, Gallus gallus. BF T03031; Pax-2.1; Species: zebra fish, Brachydanio rerio. BF T03219; Pax-2.2; Species: zebra fish, Brachydanio rerio. BF T03140; Pax-2/5/8; Species: sponge, Ephydatia fluviatilis. BF T03144; Pax-2/5/8; Species: hydra, Hydra magnipapillata. BF T00678; Pax-2a; Species: mouse, Mus musculus. BF T01822; Pax-2b; Species: mouse, Mus musculus. BF T03015; Pax-3; Species: chick, Gallus gallus. BF T01812; Pax-3A; Species: human, Homo sapiens. BF T01813; Pax-3B; Species: human, Homo sapiens. BF T00070; Pax-5; Species: human, Homo sapiens. BF T01201; Pax-5; Species: mouse, Mus musculus. BF T03016; Pax-5; Species: chick, Gallus gallus. BF T03221; Pax-5; Species: Japanese pufferfish, Fugu rubripes. BF T03223; Pax-5; Species: zebra fish, Brachydanio rerio. BF T01828; Pax-8; Species: mouse, Mus musculus. BF T01829; Pax-8; Species: rat, Rattus norvegicus. BF T02898; Pax-8; Species: human, Homo sapiens. BF T03220; Pax-8; Species: Japanese pufferfish, Fugu rubripes. BF T03222; Pax-8; Species: zebra fish, Brachydanio rerio. BF T01824; Pax-8a; Species: human, Homo sapiens. BF T02930; Pax-8a; Species: dog, Canis lupus familiaris. BF T01825; Pax-8b; Species: human, Homo sapiens. BF T01826; Pax-8c; Species: human, Homo sapiens. BF T01827; Pax-8d; Species: human, Homo sapiens. BF T02923; Pax-8e; Species: human, Homo sapiens. BF T02932; Pax-8f; Species: human, Homo sapiens. BF T02931; Pax-8g; Species: dog, Canis lupus familiaris. BF T02985; Pax-9; Species: mouse, Mus musculus. BF T02986; Pax-9; Species: human, Homo sapiens. BF T03023; Pax-9; Species: chick, Gallus gallus. BF T03593; Pax-9a; Species: zebra fish, Brachydanio rerio. BF T03594; Pax-9b; Species: zebra fish, Brachydanio rerio. BF T03089; Pax-A; Species: hydra, Hydra littoralis. BF T03095; Pax-A; Species: sea nettle, Chrysaora quinquecirrha. BF T03143; pox neuro; Species: hydra, Hydra magnipapillata. XX DR Prosite: PS00034. XX RN [1] RX MEDLINE; 87051758. RA Bopp D. Burri M. Baumgartner S. Frigerio G. Noll M. RT Conservation of a large protein domain in the segmentation gene paired and RT in functionally related genes of Drosophila RL Cell 47:1033-1049 (1986). XX // AC C0018 XX ID paired-homeo XX DT 27.09.1993 (created); ewi. DT 02.03.1995 (updated); dbo. CO Copyright (C), Biobase GmbH. XX CL paired domain, paired box + homeo domain XX CC A paired box is combined with a C-terminally located homeo domain. The CC paired box comprises approximately 130 amino acid residues. Its N-terminal CC half is basic, its C-terminal half highly charged in general. It probably CC comprises 3 alpha-helices. Three consecutive alpha-helix structures, helix CC 3 contacts mainly the major groove of the DNA, some contacts at the minor CC groove are observed as well. Helix 2 and 3 resemble the helix-turn-helix CC structure of prokaryotic regulators. XX BF T01818; Ey; Species: fruit fly, Drosophila melanogaster. BF T03207; F27E5.2; Species: Caenorhabditis elegans. BF T01820; Gsb; Species: fruit fly, Drosophila melanogaster. BF T01821; Gsbn; Species: fruit fly, Drosophila melanogaster. BF T02785; Hesx1; Species: mouse, Mus musculus. BF T02791; Hesx1; Species: human, Homo sapiens. BF T00679; Pax-3; Species: human, Homo sapiens. BF T00680; Pax-3; Species: mouse, Mus musculus. BF T02982; Pax-4; Species: human, Homo sapiens. BF T02983; Pax-4a; Species: mouse, Mus musculus. BF T03001; Pax-4a; Species: rat, Rattus norvegicus. BF T03002; Pax-4b; Species: rat, Rattus norvegicus. BF T03194; Pax-4b; Species: mouse, Mus musculus. BF T03003; Pax-4c; Species: rat, Rattus norvegicus. BF T03195; Pax-4c; Species: mouse, Mus musculus. BF T03004; Pax-4d; Species: rat, Rattus norvegicus. BF T00681; Pax-6; Species: mouse, Mus musculus. BF T00682; Pax-6; Species: zebra fish, Brachydanio rerio. BF T01122; Pax-6; Species: human, Homo sapiens. BF T01819; Pax-6; Species: sea urchin, Paracentrotus lividus. BF T03008; Pax-6; Species: rat, Rattus norvegicus. BF T03019; Pax-6; Species: chick, Gallus gallus. BF T03125; Pax-6; Species: ribbonworm, Lineus sanguineus. BF T03131; Pax-6; Species: squid, Loligo opalescens. BF T03133; Pax-6; Species: Phallusia mammilata. BF T04416; Pax-6; Species: clawed frog, Xenopus laevis. BF T02933; Pax-6 (Pax-QNR); Species: quail, Coturnix japonica. BF T01814; Pax-6 / Pd-5a; Species: human, Homo sapiens. BF T03105; Pax-6 12.1; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03111; Pax-6 12.2; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03112; Pax-6 4.1; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03110; Pax-6 4.2; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T03113; Pax-6 J2; Species: Amphioxus (Florida lancelet), Branchiostoma BF floridae. BF T00396; Pax-7; Species: human, Homo sapiens. BF T02960; Pax-7; Species: mouse, Mus musculus. BF T03021; Pax-7; Species: chick, Gallus gallus. BF T03090; Pax-B; Species: hydra, Hydra littoralis. BF T03096; Pax-B; Species: sea nettle, Chrysaora quinquecirrha. BF T00699; Prd; Species: fruit fly, Drosophila melanogaster. BF T01815; vab-3; Species: Caenorhabditis elegans. XX DR Prosite: PS00034, PS00027. XX RN [1] RX MEDLINE; 92034974. RA Wolberger C. Vershon A. K. Liu B. Johnson A. D. Pabo C. O. RT Crystal structure of a MATalpha2 homeodomain-operator complex suggests a RT general model for homeodomain-DNA interactions RL Cell 67:517-528 (1991). RN [2] RX MEDLINE; 91224486. RA Phillips C. L. Vershon A. K. Johnson A. D. Dahlquist F. W. RT Secondary structure of the homeo domain of yeast alpha2 repressor RT determined by NMR spectroscopy RL Genes Dev. 5:764-772 (1991). RN [3] RX MEDLINE; 91029489. RA Kissinger C. R. Liu B. Martin-Blanco E. Kornberg T. B. Pabo C. O. RT Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A RT resolution: a framework for understanding homeodomain-DNA interactions RL Cell 63:579-590 (1990). RN [4] RX MEDLINE; 91006000. RA Otting G. Qian Y. Q. Billeter M. Mueller M. Affolter M. Gehring W. J. RA Wuethrich K. RT Protein-DNA contacts in the structure of a homeodomain-DNA complex RT determined by nuclear magnetic resonance spectroscopy in solution RL EMBO J. 9:3085-3092 (1990). RN [5] RX MEDLINE; 90030429. RA Qian Y. G. Billeter M. Otting G. Mueller M. Gehring W. J. Wuethrich K. RT The structure of the Antennapedia homeodomain determined ny NMR RT spectroscopy in solution: comparison with prokaryotic repressors RL Cell 59:573-580 (1989). RN [6] RX MEDLINE; 89043970. RA Mihara H. Kaiser E. T. RT A chemically synthesized Antennapedia homeo domain binds to a specific DNA RT sequence RL Science 242:925-927 (1988). RN [7] RX MEDLINE; 87051758. RA Bopp D. Burri M. Baumgartner S. Frigerio G. Noll M. RT Conservation of a large protein domain in the segmentation gene paired and RT in functionally related genes of Drosophila RL Cell 47:1033-1049 (1986). XX // AC C0019 XX ID CSD XX DT 27.09.1993 (created); ewi. DT 15.07.1998 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL cold-shock domain XX CC Cold-shock domain proteins are characterized by a highly conserved region CC first found in prokaryotic cold-shock proteins [5] [2]. This domain is a CC single-stranded nucleic acid-binding structure interacting with DNA or RNA. CC It consists of an antiparallel five-stranded beta-barrel, the strands of CC which are connected by turns and loops [3] [4]. Within this structure, a CC three-stranded beta-strand contains a conserved RNA-binding motif, RNP1 [3] CC [4] [1]. Not all CSD proteins are transcription factors. Those which CC specifically bind to a certain sequence are termed Y-box proteins. - CC Proteins of this class were previously called protamine-like domain CC proteins because of having a highly positively charged domain with CC interspersed proline residues. XX BF T00185; DbpA; Species: human, Homo sapiens. BF T02498; DbpAv; Species: human, Homo sapiens. BF T00186; DbpB; Species: human, Homo sapiens. BF T00235; EFIA; Species: rat, Rattus norvegicus. BF T00236; EFIA; Species: chick, Gallus gallus. BF T00293; FRG Y1; Species: clawed frog, Xenopus laevis. BF T00294; FRG Y2; Species: clawed frog, Xenopus laevis. BF T02500; RSV-EF-II; Species: chick, Gallus gallus. BF T00910; YB-1; Species: human, Homo sapiens. BF T02496; YB-1; Species: mouse, Mus musculus. BF T02497; YB-3; Species: clawed frog, Xenopus laevis. BF T02499; Ybx-3; Species: mouse, Mus musculus. XX DR Prosite: PS00352. XX RN [1] RX MEDLINE; 96208971. RA Graumann P. Marahiel M. A. RT A case of convergent evolution of nucleic acid binding modules RL BioEssays 18:309-315 (1996). RN [2] RX MEDLINE; 94304408. RA Wolffe A. P. RT Structural and functional properties of the evolutionarily ancient Y-box RT family of nucleic acid binding proteins RL BioEssays 16:245-251 (1994). RN [3] RX MEDLINE; 93309551. RA Schnuchel A. Wiltscheck R. Czisch M. Herrler M. Willimsky G. Graumann P. RA Marahiel M. A. Holak T. A. RT Structure in solution of the major cold-shock protein from Bacillus subtilis RL Nature 364:169-171 (1993). RN [4] RX MEDLINE; 93309550. RA Schindelin H. Marahiel M. A. Heinemann U. RT Universal nucleic acid-binding domain revealed by crystal structure of the RT B. subtilis major cold-shock protein RL Nature 364:164-168 (1993). RN [5] RX MEDLINE; 92322631. RA Wolffe A. P. Tafuri S. Ranjan M. Familari M. RT The Y-box factors: a family of nucleic acid binding proteins conserved from RT Escherichia coli to man RL New Biol. 4:290-298 (1992). XX // AC C0020 XX ID Rel XX DT 27.09.1993 (created); ewi. DT 16.10.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL Rel-related factor XX CC The structure of the Rel-type DBD exhibits a bipartite subdomain structure, CC each subdomain comprising a beta-barrel with five loops that form an CC extensive contact surface to the major groove of the DNA. Particularly, the CC first loop of the N-terminal subdomain (the highly conserved recognition CC loop) performs contacts with the recognition element on the DNA, but other CC loops are involved. The fact that the main DNA-contacts are made through CC loops has been suggested to provide a high degree of flexibility in binding CC to a range of different target sequences. Augmenting interactions are CC achieved by two alpha-helices within the N-terminal part that form strong CC minor groove contacts to the A/T-rich center of the B-element. In p65, the CC sequence between both alpha-helices is much shorter and even helix 2 is CC truncated. The second, C-terminal domain is necessary mainly for protein CC dimerization. XX BF T00168; c-Rel; Species: human, Homo sapiens. BF T00169; c-Rel; Species: mouse, Mus musculus. BF T01154; c-Rel; Species: chick, Gallus gallus. BF T01934; c-Rel; Species: clawed frog, Xenopus laevis. BF T01935; c-Rel; Species: turkey, Meleagris gallopavo. BF T00196; Dl; Species: fruit fly, Drosophila melanogaster. BF T04940; NF-AT5; Species: human, Homo sapiens. BF T01945; NF-ATc; Species: human, Homo sapiens. BF T01949; NF-ATc3; Species: mouse, Mus musculus. BF T01944; NF-ATp; Species: mouse, Mus musculus. BF T01948; NF-ATp; Species: human, Homo sapiens. BF T01946; NF-ATx; Species: human, Homo sapiens. BF T00587; NF-kappaB; Species: rat, Rattus norvegicus. BF T00588; NF-kappaB; Species: mouse, Mus musculus. BF T00590; NF-kappaB; Species: human, Homo sapiens. BF T00389; NF-kappaB1; Species: rat, Rattus norvegicus. BF T00593; NF-kappaB1; Species: human, Homo sapiens. BF T01923; NF-kappaB1; Species: mouse, Mus musculus. BF T01924; NF-kappaB1 precursor; Species: mouse, Mus musculus. BF T01925; NF-kappaB1 precursor; Species: human, Homo sapiens. BF T01926; NF-kappaB1 precursor; Species: rat, Rattus norvegicus. BF T00394; NF-kappaB2; Species: human, Homo sapiens. BF T01930; NF-kappaB2 (p49); Species: human, Homo sapiens. BF T01927; NF-kappaB2 precursor; Species: human, Homo sapiens. BF T01929; NF-kappaB2 precursor; Species: chick, Gallus gallus. BF T01523; p65delta; Species: human, Homo sapiens. BF T00594; RelA; Species: human, Homo sapiens. BF T00595; RelA; Species: mouse, Mus musculus. BF T05016; RelA; Species: rat, Rattus norvegicus. BF T01931; RelB; Species: human, Homo sapiens. BF T01932; RelB; Species: mouse, Mus musculus. BF T00897; v-Rel; Species: REV-T, reticuloendotheliosis virus (strain T). XX // AC C0021 XX ID CH+homeo XX DT 27.09.1993 (created); ewi. CO Copyright (C), Biobase GmbH. XX CL zinc finger + homeo domain XX CC Molecule contains a zinc finger motif of TFIIIA/Krueppel type as well as a CC putative homeo domain. XX BF T00625; AREB6; Species: human, Homo sapiens. BF T03881; ATBF1; Species: mouse, Mus musculus. BF T03893; ATBF1; Species: chick, Gallus gallus. BF T01665; ATBF1-A; Species: human, Homo sapiens. BF T00048; ATBF1-B; Species: human, Homo sapiens. BF T01467; deltaEF1; Species: chick, Gallus gallus. BF T03915; MEB1; Species: mouse, Mus musculus. BF T00919; Zfh-1; Species: fruit fly, Drosophila melanogaster. BF T00920; Zfh-2; Species: fruit fly, Drosophila melanogaster. BF T04356; Zhx-1; Species: mouse, Mus musculus. BF T04355; ZHX1; Species: human, Homo sapiens. XX DR Prosite: PS00028, PS00027. XX // AC C0022 XX ID trp XX DT 11.04.1994 (created); ewi. DT 23.11.1995 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL tryptophan cluster XX CC The tryptophan clusters comprise several tryptophan residues with a spacing CC of 12-21 amino acid residues; the subclass of myb-type DNA-binding domains CC typically exhibit a spacing of 19-21 amino acid residues XX BF T01582; A-Myb; Species: chick, Gallus gallus. BF T01583; A-Myb; Species: human, Homo sapiens. BF T01584; A-Myb; Species: mouse, Mus musculus. BF T01585; A-Myb; Species: clawed frog, Xenopus laevis. BF T00008; Adf-1; Species: fruit fly, Drosophila melanogaster. BF T02955; AN2; Species: Petunia hybrida. BF T02912; ATR1; Species: thale cress, Arabidopsis thaliana. BF T00065; B-Myb; Species: human, Homo sapiens. BF T01586; B-Myb; Species: chick, Gallus gallus. BF T01587; B-Myb; Species: mouse, Mus musculus. BF T01027; BAS1; Species: yeast, Saccharomyces cerevisiae. BF T00137; c-Myb; Species: human, Homo sapiens. BF T00138; c-Myb; Species: mouse, Mus musculus. BF T00139; c-Myb; Species: chick, Gallus gallus. BF T01592; C1 (long form); Species: maize, Zea mays. BF T01593; C1 (short form); Species: maize, Zea mays. BF T02946; C1-I; Species: maize, Zea mays. BF T02860; CCA1; Species: thale cress, Arabidopsis thaliana. BF T02855; CDC5; Species: thale cress, Arabidopsis thaliana. BF T03285; CEF1; Species: yeast, Saccharomyces cerevisiae. BF T02911; CPC; Species: thale cress, Arabidopsis thaliana. BF T02883; CPM10; Species: Craterostigma plantagineum. BF T02882; CPM5; Species: Craterostigma plantagineum. BF T02881; CPM7; Species: Craterostigma plantagineum. BF T01570; FlbD; Species: Aspergillus nidulans, Emericella nidulans. BF T02679; GAMYB; Species: barley, Hordeum vulgare. BF T02856; GAMYB; Species: Lolium temulentum. BF T02879; GAMYB; Species: rice, Oryza sativa. BF T01588; GL1; Species: thale cress, Arabidopsis thaliana. BF T00402; ICSBP; Species: mouse, Mus musculus. BF T02037; ICSBP; Species: chick, Gallus gallus. BF T02038; ICSBP; Species: human, Homo sapiens. BF T00424; IRF-1; Species: rat, Rattus norvegicus. BF T05092; IRF-1; Species: chick, Gallus gallus. BF T00425; IRF-2; Species: mouse, Mus musculus. BF T01491; IRF-2; Species: human, Homo sapiens. BF T05091; IRF-2; Species: chick, Gallus gallus. BF T01572; IRF-4; Species: mouse, Mus musculus. BF T05103; IRF-5; Species: mouse, Mus musculus. BF T05104; IRF-5; Species: human, Homo sapiens. BF T05117; IRF-6; Species: clawed frog, Xenopus laevis. BF T05118; IRF-6; Species: human, Homo sapiens. BF T05119; IRF-6; Species: mouse, Mus musculus. BF T04674; IRF-7A; Species: human, Homo sapiens. BF T05106; IRF-7H; Species: human, Homo sapiens. BF T00422; IRF1; Species: mouse, Mus musculus. BF T00423; IRF1; Species: human, Homo sapiens. BF T01571; IRF3; Species: chick, Gallus gallus. BF T04673; IRF3; Species: human, Homo sapiens. BF T05128; Irf3; Species: mouse, Mus musculus. BF T05144; Irf7; Species: mouse, Mus musculus. BF T01456; ISGF-3gamma; Species: human, Homo sapiens. BF T02870; LHY; Species: thale cress, Arabidopsis thaliana. BF T02863; MIXTA; Species: garden snapdragon, Antirrhinum majus. BF T02864; MYB A; Species: garden snapdragon, Antirrhinum majus. BF T02535; Myb-1; Species: thale cress, Arabidopsis thaliana. BF T02613; Myb-10; Species: thale cress, Arabidopsis thaliana. BF T02608; Myb-101; Species: thale cress, Arabidopsis thaliana. BF T02609; Myb-102; Species: thale cress, Arabidopsis thaliana. BF T02614; Myb-11; Species: thale cress, Arabidopsis thaliana. BF T02615; Myb-12; Species: thale cress, Arabidopsis thaliana. BF T02542; Myb-13; Species: thale cress, Arabidopsis thaliana. BF T02616; Myb-14; Species: thale cress, Arabidopsis thaliana. BF T02534; Myb-15; Species: thale cress, Arabidopsis thaliana. BF T02543; Myb-16; Species: thale cress, Arabidopsis thaliana. BF T02617; Myb-17; Species: thale cress, Arabidopsis thaliana. BF T02618; Myb-18; Species: thale cress, Arabidopsis thaliana. BF T02619; Myb-19; Species: thale cress, Arabidopsis thaliana. BF T02620; Myb-20; Species: thale cress, Arabidopsis thaliana. BF T02544; Myb-21; Species: thale cress, Arabidopsis thaliana. BF T02545; Myb-22; Species: thale cress, Arabidopsis thaliana. BF T02546; Myb-23; Species: thale cress, Arabidopsis thaliana. BF T02547; Myb-24; Species: thale cress, Arabidopsis thaliana. BF T02548; Myb-25; Species: thale cress, Arabidopsis thaliana. BF T02549; Myb-26; Species: thale cress, Arabidopsis thaliana. BF T02621; Myb-27; Species: thale cress, Arabidopsis thaliana. BF T02550; Myb-28; Species: thale cress, Arabidopsis thaliana. BF T02622; Myb-29; Species: thale cress, Arabidopsis thaliana. BF T02610; Myb-3; Species: thale cress, Arabidopsis thaliana. BF T02551; Myb-30; Species: thale cress, Arabidopsis thaliana. BF T02552; Myb-31; Species: thale cress, Arabidopsis thaliana. BF T02553; Myb-32; Species: thale cress, Arabidopsis thaliana. BF T02623; Myb-33; Species: thale cress, Arabidopsis thaliana. BF T02554; Myb-34; Species: thale cress, Arabidopsis thaliana. BF T02624; Myb-35; Species: thale cress, Arabidopsis thaliana. BF T02555; Myb-36; Species: thale cress, Arabidopsis thaliana. BF T02625; Myb-37; Species: thale cress, Arabidopsis thaliana. BF T02626; Myb-38; Species: thale cress, Arabidopsis thaliana. BF T02556; Myb-39; Species: thale cress, Arabidopsis thaliana. BF T02611; Myb-4; Species: thale cress, Arabidopsis thaliana. BF T02627; Myb-40; Species: thale cress, Arabidopsis thaliana. BF T02628; Myb-41; Species: thale cress, Arabidopsis thaliana. BF T02557; Myb-42; Species: thale cress, Arabidopsis thaliana. BF T02558; Myb-43; Species: thale cress, Arabidopsis thaliana. BF T02559; Myb-44; Species: thale cress, Arabidopsis thaliana. BF T02560; Myb-45; Species: thale cress, Arabidopsis thaliana. BF T02561; Myb-46; Species: thale cress, Arabidopsis thaliana. BF T02562; Myb-47; Species: thale cress, Arabidopsis thaliana. BF T02563; Myb-48; Species: thale cress, Arabidopsis thaliana. BF T02564; Myb-49; Species: thale cress, Arabidopsis thaliana. BF T02538; Myb-5; Species: thale cress, Arabidopsis thaliana. BF T02565; Myb-50; Species: thale cress, Arabidopsis thaliana. BF T02566; Myb-51; Species: thale cress, Arabidopsis thaliana. BF T02567; Myb-52; Species: thale cress, Arabidopsis thaliana. BF T02568; Myb-53; Species: thale cress, Arabidopsis thaliana. BF T02569; Myb-54; Species: thale cress, Arabidopsis thaliana. BF T02570; Myb-55; Species: thale cress, Arabidopsis thaliana. BF T02571; Myb-56; Species: thale cress, Arabidopsis thaliana. BF T02572; Myb-57; Species: thale cress, Arabidopsis thaliana. BF T02573; Myb-58; Species: thale cress, Arabidopsis thaliana. BF T02574; Myb-59; Species: thale cress, Arabidopsis thaliana. BF T02539; Myb-6; Species: thale cress, Arabidopsis thaliana. BF T02575; Myb-60; Species: thale cress, Arabidopsis thaliana. BF T02576; Myb-61; Species: thale cress, Arabidopsis thaliana. BF T02577; Myb-62; Species: thale cress, Arabidopsis thaliana. BF T02578; Myb-63; Species: thale cress, Arabidopsis thaliana. BF T02629; Myb-64; Species: thale cress, Arabidopsis thaliana. BF T02579; Myb-65; Species: thale cress, Arabidopsis thaliana. BF T02580; Myb-66; Species: thale cress, Arabidopsis thaliana. BF T02581; Myb-67; Species: thale cress, Arabidopsis thaliana. BF T02582; Myb-68; Species: thale cress, Arabidopsis thaliana. BF T02583; Myb-69; Species: thale cress, Arabidopsis thaliana. BF T02540; Myb-7; Species: thale cress, Arabidopsis thaliana. BF T02584; Myb-70; Species: thale cress, Arabidopsis thaliana. BF T02585; Myb-71; Species: thale cress, Arabidopsis thaliana. BF T02586; Myb-72; Species: thale cress, Arabidopsis thaliana. BF T02587; Myb-73; Species: thale cress, Arabidopsis thaliana. BF T02588; Myb-74; Species: thale cress, Arabidopsis thaliana. BF T02589; Myb-75; Species: thale cress, Arabidopsis thaliana. BF T02630; Myb-76; Species: thale cress, Arabidopsis thaliana. BF T02590; Myb-77; Species: thale cress, Arabidopsis thaliana. BF T02591; Myb-78; Species: thale cress, Arabidopsis thaliana. BF T02592; Myb-79; Species: thale cress, Arabidopsis thaliana. BF T02541; Myb-8; Species: thale cress, Arabidopsis thaliana. BF T02631; Myb-80; Species: thale cress, Arabidopsis thaliana. BF T02593; Myb-81; Species: thale cress, Arabidopsis thaliana. BF T02594; Myb-82; Species: thale cress, Arabidopsis thaliana. BF T02596; Myb-83; Species: thale cress, Arabidopsis thaliana. BF T02597; Myb-84; Species: thale cress, Arabidopsis thaliana. BF T02598; Myb-85; Species: thale cress, Arabidopsis thaliana. BF T02600; Myb-86; Species: thale cress, Arabidopsis thaliana. BF T02601; Myb-87; Species: thale cress, Arabidopsis thaliana. BF T02602; Myb-88; Species: thale cress, Arabidopsis thaliana. BF T02632; Myb-89; Species: thale cress, Arabidopsis thaliana. BF T02612; Myb-9; Species: thale cress, Arabidopsis thaliana. BF T02603; Myb-90; Species: thale cress, Arabidopsis thaliana. BF T02604; Myb-91; Species: thale cress, Arabidopsis thaliana. BF T02605; Myb-92; Species: thale cress, Arabidopsis thaliana. BF T02606; Myb-93; Species: thale cress, Arabidopsis thaliana. BF T02607; Myb-94; Species: thale cress, Arabidopsis thaliana. BF T03005; MYB-P1; Species: Perilla frutescens. BF T03468; MYB.PH1; Species: Petunia hybrida. BF T02890; MYB.PH2; Species: Petunia hybrida. BF T01568; MYB.PH3; Species: Petunia hybrida. BF T02869; MYB1; Species: rice, Oryza sativa. BF T02876; MYB1; Species: parsley, Petroselinum crispum (P. hortense). BF T02880; MYB1; Species: tobacco, Nicotiana tabacum. BF T02887; MYB1; Species: barley, Hordeum vulgare. BF T02536; MYB2; Species: thale cress, Arabidopsis thaliana. BF T02868; MYB2; Species: rice, Oryza sativa. BF T02888; MYB2; Species: barley, Hordeum vulgare. BF T02874; MYB26; Species: pea, Pisum sativum. BF T02867; MYB3; Species: rice, Oryza sativa. BF T02889; MYB3; Species: barley, Hordeum vulgare. BF T02907; MYB305; Species: garden snapdragon, Antirrhinum majus. BF T02925; MYB306; Species: garden snapdragon, Antirrhinum majus. BF T02926; MYB308; Species: garden snapdragon, Antirrhinum majus. BF T02927; MYB315; Species: garden snapdragon, Antirrhinum majus. BF T02928; MYB330; Species: garden snapdragon, Antirrhinum majus. BF T02929; MYB340; Species: garden snapdragon, Antirrhinum majus. BF T04709; Myb3R-1; Species: thale cress, Arabidopsis thaliana. BF T04710; Myb3R-1; Species: Secale cereale. BF T04711; Myb3R-1; Species: Adiantum raddianum, delta maidenhair fern. BF T04713; Myb3R-1; Species: Physcomitrella patens. BF T04714; Myb3R-1; Species: barley, Hordeum vulgare. BF T04712; Myb3R-2; Species: Adiantum raddianum, delta maidenhair fern. BF T02866; MYB4; Species: rice, Oryza sativa. BF T02865; MYB5; Species: rice, Oryza sativa. BF T04782; MYB7; Species: rice, Oryza sativa. BF T04389; MybI; Species: tomato, Lycopersicon esculentum. BF T01589; MYBST1; Species: potato, Solanum tuberosum. BF T01412; NF-EM5; Species: mouse, Mus musculus. BF T01590; P (long form); Species: maize, Zea mays. BF T01591; P (short form); Species: maize, Zea mays. BF T02920; P-wr; Species: maize, Zea mays. BF T02934; PBP; Species: tobacco, Nicotiana tabacum. BF T00685; PEA3; Species: human, Homo sapiens. BF T02871; PHAN; Species: garden snapdragon, Antirrhinum majus. BF T02891; PP1; Species: Physcomitrella patens. BF T02893; PP2; Species: Physcomitrella patens. BF T00725; REB1; Species: yeast, Saccharomyces cerevisiae. BF T01245; Reb1p; Species: yeast, Kluyveromyces lactis. BF T02859; RS2; Species: maize, Zea mays. BF T02885; THM1; Species: tomato, Lycopersicon esculentum. BF T02873; THM18; Species: tomato, Lycopersicon esculentum. BF T02886; THM27; Species: tomato, Lycopersicon esculentum. BF T04596; TT2; Species: thale cress, Arabidopsis thaliana. BF T00895; v-Myb; Species: AMV, avian myeloblastosis virus. BF T01594; v-Myb/v-Ets; Species: AEV, avian erythroblastosis virus. BF T02958; ZM1; Species: maize, Zea mays. BF T02959; ZM38; Species: maize, Zea mays. XX DR Prosite: PS00037, PS00334. XX RN [1] RX MEDLINE; 90377212. RA Ju Q. Morrow B. E. Warner J. R. RT REB1, a yeast DNA-binding protein with many targets, is essential for cell RT growth and bears some resemblance to the oncogene myb RL Mol. Cell. Biol. 10:5226-5234 (1990). XX // AC C0023 XX ID fork head XX DT 05.05.1994 (created); ewi. DT 12.09.1995 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL fork head domain XX CC Identified by homology between HNF-3A and fkh. The domain comprises approx. CC 110 AA. Analysis of the crystal structure has revealed a compact structure CC of three alpha-helices, the third alpha-helix being exposed towards the CC major groove of the DNA. The domain also exerts minor groove contacts. Upon CC binding to DNA, it induces a bend of 13 degree. XX BF T01834; Axial; Species: zebra fish, Brachydanio rerio. BF T02491; cFkh-1; Species: chick, Gallus gallus. BF T02291; Croc; Species: fruit fly, Drosophila melanogaster. BF T02493; CWH-1; Species: chick, Gallus gallus. BF T02494; CWH-2; Species: chick, Gallus gallus. BF T02495; CWH-3; Species: chick, Gallus gallus. BF T03398; daf-16a1; Species: Caenorhabditis elegans. BF T03399; daf-16a2; Species: Caenorhabditis elegans. BF T03400; daf-16b; Species: Caenorhabditis elegans. BF T01550; DP; Species: fruit fly, Drosophila melanogaster. BF T01548; DP-1; Species: human, Homo sapiens. BF T01549; DP-1; Species: mouse, Mus musculus. BF T03000; DP-2; Species: human, Homo sapiens. BF T04103; DP-3; Species: mouse, Mus musculus. BF T00221; E2F; Species: human, Homo sapiens. BF T01547; E2F; Species: fruit fly, Drosophila melanogaster. BF T04056; E2F; Species: mouse, Mus musculus. BF T04747; E2F; Species: rat, Rattus norvegicus. BF T00232; E2F+E4; Species: human, Homo sapiens. BF T01542; E2F-1; Species: human, Homo sapiens. BF T01543; E2F-1; Species: mouse, Mus musculus. BF T02951; E2F-1; Species: chick, Gallus gallus. BF T02952; E2F-1; Species: rat, Rattus norvegicus. BF T01544; E2F-2; Species: human, Homo sapiens. BF T02950; E2F-2; Species: fruit fly, Drosophila melanogaster. BF T03526; E2F-2; Species: mouse, Mus musculus. BF T01545; E2F-3; Species: human, Homo sapiens. BF T02947; E2F-3A; Species: mouse, Mus musculus. BF T04107; E2F-3B; Species: mouse, Mus musculus. BF T01546; E2F-4; Species: human, Homo sapiens. BF T01607; E2F-5; Species: human, Homo sapiens. BF T02948; E2F-5; Species: mouse, Mus musculus. BF T03249; E2F-5; Species: rat, Rattus norvegicus. BF T02997; E2F-6; Species: human, Homo sapiens. BF T03250; E2F-6; Species: mouse, Mus musculus. BF T03302; FHL1; Species: yeast, Saccharomyces cerevisiae. BF T01054; Fkh; Species: fruit fly, Drosophila melanogaster. BF T03303; FKH1; Species: yeast, Saccharomyces cerevisiae. BF T03304; FKH2; Species: yeast, Saccharomyces cerevisiae. BF T02440; FKHL18; Species: mouse, Mus musculus. BF T02454; FKHL18; Species: human, Homo sapiens. BF T02940; FKHRL1P2; Species: human, Homo sapiens. BF T01051; FOXA4a; Species: clawed frog, Xenopus laevis. BF T01830; FOXA4b; Species: clawed frog, Xenopus laevis. BF T02443; FOXB1; Species: mouse, Mus musculus. BF T04165; FOXB1; Species: human, Homo sapiens. BF T02442; FOXB2; Species: mouse, Mus musculus. BF T02426; FOXC1; Species: mouse, Mus musculus. BF T02471; FOXC1; Species: human, Homo sapiens. BF T02445; FOXC2; Species: mouse, Mus musculus. BF T02518; FOXC2; Species: human, Homo sapiens. BF T02293; FOXD1; Species: mouse, Mus musculus. BF T02472; FOXD1; Species: human, Homo sapiens. BF T02485; FOXD2; Species: human, Homo sapiens. BF T02492; FOXD2; Species: mouse, Mus musculus. BF T02290; FOXD3; Species: rat, Rattus norvegicus. BF T04166; FOXD3; Species: mouse, Mus musculus. BF T04167; FOXD3; Species: human, Homo sapiens. BF T02431; FOXD4; Species: mouse, Mus musculus. BF T02473; FOXD4; Species: human, Homo sapiens. BF T04172; FOXD5a; Species: clawed frog, Xenopus laevis. BF T04173; FOXD5b; Species: clawed frog, Xenopus laevis. BF T04174; FOXD5c; Species: clawed frog, Xenopus. BF T01133; FOXE1; Species: rat, Rattus norvegicus. BF T02782; FOXE1; Species: human, Homo sapiens. BF T02476; FOXE3; Species: human, Homo sapiens. BF T02484; FOXE3; Species: rat, Rattus norvegicus. BF T02461; FOXF1; Species: mouse, Mus musculus. BF T02464; FOXF1; Species: human, Homo sapiens. BF T02465; FOXF2; Species: human, Homo sapiens. BF T02514; FOXF2; Species: mouse, Mus musculus. BF T01831; FOXG1; Species: rat, Rattus norvegicus. BF T01833; FOXG1; Species: chick, Gallus gallus. BF T02353; FOXG1; Species: mouse, Mus musculus. BF T04260; FOXG1; Species: clawed frog, Xenopus laevis. BF T02292; FOXG1a; Species: human, Homo sapiens. BF T02350; FOXG1b; Species: human, Homo sapiens. BF T04259; FOXG1c; Species: human, Homo sapiens. BF T04119; FOXH1; Species: human, Homo sapiens. BF T04120; FOXH1; Species: mouse, Mus musculus. BF T04135; FOXH1; Species: clawed frog, Xenopus laevis. BF T04100; FOXH2; Species: mouse, Mus musculus. BF T02474; FOXI1; Species: human, Homo sapiens. BF T02480; FOXI1; Species: rat, Rattus norvegicus. BF T02294; FOXI1a; Species: clawed frog, Xenopus laevis. BF T02460; FOXJ1; Species: mouse, Mus musculus. BF T02520; FOXJ1; Species: rat, Rattus norvegicus. BF T02519; FOXJ1a; Species: human, Homo sapiens. BF T04221; FOXJ1b; Species: human, Homo sapiens. BF T04170; FOXJ2; Species: mouse, Mus musculus. BF T04169; FOXJ2 (long isoform); Species: human, Homo sapiens. BF T04171; FOXJ2 (short isoform); Species: human, Homo sapiens. BF T04179; FOXJ3; Species: human, Homo sapiens. BF T04216; FOXK1; Species: mouse, Mus musculus. BF T01088; FOXK1a; Species: human, Homo sapiens. BF T04212; FOXK1b; Species: human, Homo sapiens. BF T04211; FOXK1c; Species: human, Homo sapiens. BF T02417; FOXL1; Species: mouse, Mus musculus. BF T02475; FOXL1; Species: human, Homo sapiens. BF T04890; FOXL2; Species: human, Homo sapiens. BF T02515; FOXM1; Species: mouse, Mus musculus. BF T04208; FOXM1; Species: rat, Rattus norvegicus. BF T02517; FOXM1a; Species: human, Homo sapiens. BF T02516; FOXM1b; Species: human, Homo sapiens. BF T04207; FOXM1c; Species: human, Homo sapiens. BF T01835; FOXN1; Species: mouse, Mus musculus. BF T02525; FOXN1; Species: human, Homo sapiens. BF T02526; FOXN1; Species: rat, Rattus norvegicus. BF T04205; FOXN2; Species: mouse, Mus musculus. BF T04206; FOXN2; Species: human, Homo sapiens. BF T04204; FOXN3; Species: human, Homo sapiens. BF T04203; FOXO1; Species: mouse, Mus musculus. BF T02936; FOXO1a; Species: human, Homo sapiens. BF T02937; FOXO1b; Species: human, Homo sapiens. BF T04177; FOXO2; Species: human, Homo sapiens. BF T04178; FOXO3; Species: mouse, Mus musculus. BF T02938; FOXO3a; Species: human, Homo sapiens. BF T02939; FOXO3b; Species: human, Homo sapiens. BF T03403; FOXO4; Species: human, Homo sapiens. BF T04176; FOXO4; Species: mouse, Mus musculus. BF T04202; FOXO5; Species: chick, Gallus gallus. BF T04724; FOXO5; Species: zebra fish, Brachydanio rerio. BF T04175; FOXP1; Species: human, Homo sapiens. BF T04815; FOXP1; Species: mouse, Mus musculus. BF T04811; FOXP1a; Species: mouse, Mus musculus. BF T04812; FOXP1b; Species: mouse, Mus musculus. BF T04813; FOXP1c; Species: mouse, Mus musculus. BF T04814; FOXP2; Species: mouse, Mus musculus. BF T04816; FOXP2; Species: human, Homo sapiens. BF T04279; FOXP3; Species: mouse, Mus musculus. BF T04280; FOXP3; Species: human, Homo sapiens. BF T01256; HCM1; Species: yeast, Saccharomyces cerevisiae. BF T02288; HFH-1; Species: rat, Rattus norvegicus. BF T02479; HFH-3; Species: rat, Rattus norvegicus. BF T02487; HFH-3; Species: mouse, Mus musculus. BF T02481; HFH-6; Species: rat, Rattus norvegicus. BF T00370; HNF-3; Species: mouse, Mus musculus. BF T03260; HNF-3; Species: atlantic salmon, Salmo salar. BF T00371; HNF-3alpha; Species: rat, Rattus norvegicus. BF T02343; HNF-3alpha; Species: mouse, Mus musculus. BF T02512; HNF-3alpha; Species: human, Homo sapiens. BF T01049; HNF-3B; Species: rat, Rattus norvegicus. BF T04889; HNF-3b; Species: human, Homo sapiens. BF T01053; HNF-3beta; Species: clawed frog, Xenopus laevis. BF T02344; HNF-3beta; Species: mouse, Mus musculus. BF T02513; HNF-3beta; Species: human, Homo sapiens. BF T03256; HNF-3beta; Species: chick, Gallus gallus. BF T01050; HNF-3gamma; Species: rat, Rattus norvegicus. BF T02345; HNF-3gamma; Species: mouse, Mus musculus. BF T02418; HNF-3gamma; Species: human, Homo sapiens. BF T01057; lin-31; Species: Caenorhabditis elegans. BF T04301; mei4; Species: fission yeast, Schizosaccharomyces pombe. BF T03396; pes-1a; Species: Caenorhabditis elegans. BF T03397; pes-1b; Species: Caenorhabditis elegans. BF T02446; pha-4; Species: Caenorhabditis elegans. BF T02289; QRF-1; Species: mouse, Mus musculus. BF T00744; SGF-1; Species: silk moth, Bombyx mori. BF T01055; Slp1; Species: fruit fly, Drosophila melanogaster. BF T01056; slp2; Species: fruit fly, Drosophila melanogaster. BF T01277; spE2F; Species: fission yeast, Schizosaccharomyces pombe. BF T01832; v-Qin; Species: ASV 31, avian sarcoma virus 31. BF T01052; XFD-1+; Species: clawed frog, Xenopus laevis. XX DR Prosite: PS00657, PS00658. XX RN [1] RX MEDLINE; 93323996. RA Clark K. L. Halay E. D. Lai E. Burley S. K. RT Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles RT histone H5 RL Nature 364:412-420 (1993). RN [2] RX MEDLINE; 91029477. RA Weigel D. Jaeckle H. RT The fork head domain: a novel DNA binding motif of eukaryotic transcription RT factors? RL Cell 63:455-456 (1990). RN [3] RX MEDLINE; 91032994. RA Lai E. Prezioso V. R. Smith E. Litvin O. Costa R. H. Darnell J. E. RT HNF-3A, a hepatocyte-enriched transcription factor of novel structure is RT regulated transcriptionally RL Genes Dev. 4:1427-1436 (1990). XX // AC C0024 XX ID TEA XX DT 05.05.1994 (created); ewi. DT 16.10.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL TEA domain XX CC The TEA domain has been identified as a region which is conserved among the CC transcription factors TEF-1, TEC1 and abaA. This domain in TEF-1 has been CC shown to interact with DNA, although two additional regions may also CC contribute to DNA-binding. It is predicted to fold into three CC alpha-helices, with a randomly coiled region of 16-18 amino acid residues CC between helices 1 and 2, and a short stretch between helices 2 and 3 of 3-8 CC residues. XX BF T01085; abaA; Species: Aspergillus nidulans, Emericella nidulans. BF T02030; Sd; Species: fruit fly, Drosophila melanogaster. BF T01084; TEC1; Species: yeast, Saccharomyces cerevisiae. BF T00806; TEF-1; Species: human, Homo sapiens. BF T01124; TEF-1; Species: mouse, Mus musculus. BF T04951; TEF-3; Species: human, Homo sapiens. BF T04952; TEF-5; Species: human, Homo sapiens. XX DR Prosite: PS00554. XX RN [1] RX MEDLINE; 91300541. RA Buerglin T. R. RT The TEA domain: a novel, highly conserved DNA-binding motif RL Cell 66:11-12 (1991). XX // AC C0025 XX ID LIM-homeo XX DT 05.05.1994 (created); ewi. DT 21.11.1996 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL LIM domain plus homeo domain XX CC Lim motif has been identified by homology between lin-11, Isl-1, and mec-3. CC It consists of about 60 amino acids with a conserved pattern of cysteine CC and histidine residues. It is a zinc-binding domain most likely involved in CC protein-protein contacts [5] [3] [1] [2]. The homeo domain consists of CC three consecutive alpha-helix structures, helix 3 contacts mainly the major CC groove of the DNA, some contacts at the minor groove are observed as well. CC Helix 2 and 3 resemble the helix-turn-helix structure of prokaryotic CC regulators. XX BF T01074; Ap; Species: fruit fly, Drosophila melanogaster. BF T03385; CeLim-4; Species: Caenorhabditis elegans. BF T03384; CeLim-6; Species: Caenorhabditis elegans. BF T03377; CeLim-7; Species: Caenorhabditis elegans. BF T01035; Isl-1; Species: rat, Rattus rattus. BF T01956; Isl-1; Species: chick, Gallus gallus. BF T01957; Isl-1; Species: human, Homo sapiens. BF T01960; LHX1; Species: human, Homo sapiens. BF T01961; Lhx1; Species: mouse, Mus musculus. BF T04264; Lhx1; Species: golden hamster, Mesocricetus auratus. BF T01966; Lhx2; Species: rat, Rattus norvegicus. BF T01967; LHX2; Species: human, Homo sapiens. BF T01968; Lhx2; Species: chick, Gallus gallus. BF T01969; Lhx2; Species: mouse, Mus musculus. BF T01964; Lhx3a; Species: mouse, Mus musculus. BF T03446; LHX3a; Species: human, Homo sapiens. BF T03447; LHX3b; Species: human, Homo sapiens. BF T04840; Lhx3b; Species: mouse, Mus musculus. BF T03542; Lhx4; Species: mouse, Mus musculus. BF T04180; LHX5; Species: human, Homo sapiens. BF T04181; Lhx5; Species: mouse, Mus musculus. BF T04209; Lhx5; Species: clawed frog, Xenopus laevis. BF T04184; Lhx6; Species: mouse, Mus musculus. BF T04187; Lhx6.1a; Species: mouse, Mus musculus. BF T04189; LHX6.1a; Species: human, Homo sapiens. BF T04188; Lhx6.1b; Species: mouse, Mus musculus. BF T04190; LHX6.1b; Species: human, Homo sapiens. BF T04185; Lhx7; Species: mouse, Mus musculus. BF T04186; Lhx7a; Species: mouse, Mus musculus. BF T04191; Lhx8; Species: mouse, Mus musculus. BF T04192; Lhx9; Species: mouse, Mus musculus. BF T04195; Lhx9 alpha; Species: mouse, Mus musculus. BF T01959; Lim-1; Species: chick, Gallus gallus. BF T01962; Lim-1; Species: clawed frog, Xenopus laevis. BF T01963; Lim-3; Species: clawed frog, Xenopus laevis. BF T01965; Lim-3; Species: chick, Gallus gallus. BF T01075; lin-11; Species: Caenorhabditis elegans. BF T01958; Lmx1; Species: golden hamster, Mesocricetus auratus. BF T04300; Lmx1a; Species: mouse, Mus musculus. BF T04302; LMX1A; Species: human, Homo sapiens. BF T04293; LMX1B; Species: human, Homo sapiens. BF T04303; Lmx1b; Species: mouse, Mus musculus. BF T04304; Lmx1b; Species: rat, Rattus norvegicus. BF T01076; mec-3; Species: Caenorhabditis elegans. BF T01970; mec-3; Species: Caenorhabditis vulgarensis. BF T03380; ttx-3; Species: Caenorhabditis elegans. XX DR Prosite: PS00478, PS00027. XX RN [1] RX MEDLINE; 95024173. RA Feuerstein R. Wang X. Song D. Cooke N. E. Liebhaber S. A. RT The LIM/double zinc finger motif functions as a protein dimerization domain RL Proc. Natl. Acad. Sci. USA 91:10655-10659 (1994). RN [2] RX MEDLINE; 95042719. RA Schmeichel K. L. Beckerle M. C. RT The LIM domain is a modular protein-binding interface RL Cell 79:211-219 (1994). RN [3] RX MEDLINE; 93281587. RA Michelsen J. W. Schmeichel K. L. Beckerle M. C. Winge D. R. RT The LIM motif defines a specific zinc-binding protein domain RL Proc. Natl. Acad. Sci. USA 90:4404-4408 (1993). RN [4] RX MEDLINE; 92249766. RA Cohen B. McGuffin E. Pfeifle C. Segal D. Cohen S. M. RT apterous, a gene required for imaginal disc development in Drosophila RT encodes a member of the LIM family of developmental regulatory proteins RL Genes Dev. 6:715-729 (1992). RN [5] RX MEDLINE; 92021020. RA Li P. M. Reichert J. Freyd G. Horvitz H. R. Walsh C. T. RT The LIM region of a presumptive Caenorhabditis elegans transcription factor RT is an iron-sulfur- and zinc-containing metallodomain RL Proc. Natl. Acad. Sci. USA 88:9210-9213 (1991). XX // AC C0026 XX ID HTH XX DT 12.07.1994 (created); ewi. CO Copyright (C), Biobase GmbH. XX CL helix-turn-helix XX CC Contains the motif alpha-helix - beta-turn - alpha-helix known from CC prokaryotic repressors. XX BF T01018; CAP; Species: E.coli, Escherichia coli. XX RN [1] RX MEDLINE; 92115725. RA England B. P. Admon A. Tjian R. RT Cloning of Drosophila transcription factor Adf-1 reveals homology to Myb RT oncoproteins RL Proc. Natl. Acad. Sci. USA 89:683-687 (1992). RN [2] RX MEDLINE; 90245566. RA Ewel A. Jackson J. R. Benyajati C. RT Alternative DNA-protein interactions in variable-length internucleosomal RT regions associated with Drosophila Adh distal promoter expression RL Nucleic Acids Res. 18:1771-1781 (1990). RN [3] RX MEDLINE; 89365161. RA Lin Y.-S. Green M. R. RT Similarities between prokaryotic and eukaryotic cyclic AMP-responsive RT promoter elements RL Nature 340:656-659 (1989). RN [4] RX MEDLINE; 88122611. RA Heberlein U. Tjian R. RT Temporal pattern of alcohol dehydrogenase gene transcription reproduced by RT Drosophila stage-specific embryonic extracts RL Nature 331:410-415 (1988). RN [5] RX MEDLINE; 85228247. RA Heberlein U. England B. Tjian R. RT Characterization of Drosophila transcription factors that activate the RT tandem promoters of the alcohol dehydrogenase gene RL Cell 41:965-977 (1985). XX // AC C0027 XX ID homeo-Zip XX DT 02.05.1995 (created); ewi. DT 02.05.1995 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL homeodomain plus leucine zipper XX CC Three consecutive alpha-helix structures, helix 3 contacts mainly the major CC groove of the DNA, some contacts at the minor groove are observed as well. CC Helix 2 and 3 resemble the helix-turn-helix structure of prokaryotic CC regulators. The leucine zipper consists of repeated leucine residues at CC every seventh position and mediates protein dimerization as a prerequisite CC for DNA-binding. The leucines are directed towards one side of an CC alpha-helix. The leucine side chains of two polypeptides are thought to CC interdigitate upon dimerization (knobs-into-holes model). XX BF T01474; ATHB-1; Species: thale cress, Arabidopsis thaliana. BF T04006; ATHB-12; Species: thale cress, Arabidopsis thaliana. BF T04805; ATHB-13; Species: thale cress, Arabidopsis thaliana. BF T04004; ATHB-14; Species: thale cress, Arabidopsis thaliana. BF T04806; ATHB-16; Species: thale cress, Arabidopsis thaliana. BF T01475; ATHB-2; Species: thale cress, Arabidopsis thaliana. BF T04066; ATHB-5; Species: thale cress, Arabidopsis thaliana. BF T04028; ATHB-6; Species: thale cress, Arabidopsis thaliana. BF T04068; ATHB-7; Species: thale cress, Arabidopsis thaliana. BF T04000; ATHB-8; Species: thale cress, Arabidopsis thaliana. BF T04001; ATHB-9; Species: thale cress, Arabidopsis thaliana. BF T04064; ATHB4; Species: thale cress, Arabidopsis thaliana. BF T04087; CHB1; Species: carrot, Daucus carota. BF T04088; CHB2; Species: carrot, Daucus carota. BF T04089; CHB3; Species: carrot, Daucus carota. BF T04090; CHB4; Species: carrot, Daucus carota. BF T04091; CHB5; Species: carrot, Daucus carota. BF T04092; CHB6; Species: carrot, Daucus carota. BF T04164; CPHB-1; Species: Craterostigma plantagineum. BF T04168; CPHB-2; Species: Craterostigma plantagineum. BF T02961; GLABRA2; Species: thale cress, Arabidopsis thaliana. BF T04086; GMH1; Species: soybean, Glycine max. BF T04070; HAHB-1; Species: sunflower, Helianthus annuus. BF T04082; HAHB-10; Species: sunflower, Helianthus annuus. BF T04071; HAHB-2; Species: sunflower, Helianthus annuus. BF T04072; HAHB-3; Species: thale cress, Arabidopsis thaliana. BF T04073; HAHB-4; Species: sunflower, Helianthus annuus. BF T04078; HAHB-5; Species: sunflower, Helianthus annuus. BF T04079; HAHB-6; Species: sunflower, Helianthus annuus. BF T04080; HAHB-7; Species: sunflower, Helianthus annuus. BF T04081; HAHB-9; Species: sunflower, Helianthus annuus. BF T04007; HAT1; Species: thale cress, Arabidopsis thaliana. BF T04026; HAT14; Species: thale cress, Arabidopsis thaliana. BF T04008; HAT2; Species: thale cress, Arabidopsis thaliana. BF T04027; HAT22; Species: thale cress, Arabidopsis thaliana. BF T04009; HAT3; Species: thale cress, Arabidopsis thaliana. BF T04011; HAT7; Species: thale cress, Arabidopsis thaliana. BF T04025; HAT9; Species: thale cress, Arabidopsis thaliana. BF T03810; HOX1; Species: rice, Oryza sativa. BF T03812; HOX2; Species: rice, Oryza sativa. BF T03813; HOX3; Species: rice, Oryza sativa. BF T03815; HOX4; Species: rice, Oryza sativa. BF T03816; HOX5; Species: rice, Oryza sativa. BF T03817; HOX6; Species: rice, Oryza sativa. BF T03818; HOX7; Species: rice, Oryza sativa. BF T04029; IFL1; Species: thale cress, Arabidopsis thaliana. BF T04828; OCL1; Species: maize, Zea mays. BF T04829; OCL2; Species: maize, Zea mays. BF T04830; OCL3; Species: maize, Zea mays. BF T04831; OCL4; Species: maize, Zea mays. BF T04832; OCL5; Species: maize, Zea mays. BF T04083; PHZ1; Species: Pimpinella brachycarpa. BF T04084; PHZ2; Species: Pimpinella brachycarpa. BF T04085; PHZ4; Species: Pimpinella brachycarpa. BF T04094; THOM1; Species: tomato, Lycopersicon esculentum. BF T04093; VAHOX1; Species: tomato, Lycopersicon esculentum. XX DR Prosite: PS00027. XX RN [1] RX MEDLINE; 94074550. RA Sessa G. Morelli G. Ruberti I. RT The Athb-1 and -2 HD-Zip domains homodimerize forming complexes of RT different DNA binding specificities RL EMBO J. 12:3507-3517 (1993). XX // AC C0028 XX ID LIM XX DT 21.11.1996 (created); ewi. DT 21.11.1996 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL LIM domain XX CC Lim motif has been identified by homology between lin-11, Isl-1, and mec-3. CC It consists of about 60 amino acids with a conserved pattern of cysteine CC and histidine residues. It is a zinc-binding domain most likely involved in CC protein-protein contacts [4] [3] [1] [2]. XX BF T01972; DMLP1; Species: fruit fly, Drosophila melanogaster. BF T04817; LIM1; Species: tobacco, Nicotiana tabacum. BF T02249; Lmo1; Species: human, Homo sapiens. BF T02250; Lmo2; Species: human, Homo sapiens. BF T02251; Lmo2; Species: mouse, Mus musculus. BF T01971; MLP; Species: rat, Rattus norvegicus. XX DR Prosite: PS00478, PS00027. XX RN [1] RX MEDLINE; 95024173. RA Feuerstein R. Wang X. Song D. Cooke N. E. Liebhaber S. A. RT The LIM/double zinc finger motif functions as a protein dimerization domain RL Proc. Natl. Acad. Sci. USA 91:10655-10659 (1994). RN [2] RX MEDLINE; 95042719. RA Schmeichel K. L. Beckerle M. C. RT The LIM domain is a modular protein-binding interface RL Cell 79:211-219 (1994). RN [3] RX MEDLINE; 93281587. RA Michelsen J. W. Schmeichel K. L. Beckerle M. C. Winge D. R. RT The LIM motif defines a specific zinc-binding protein domain RL Proc. Natl. Acad. Sci. USA 90:4404-4408 (1993). RN [4] RX MEDLINE; 92021020. RA Li P. M. Reichert J. Freyd G. Horvitz H. R. Walsh C. T. RT The LIM region of a presumptive Caenorhabditis elegans transcription factor RT is an iron-sulfur- and zinc-containing metallodomain RL Proc. Natl. Acad. Sci. USA 88:9210-9213 (1991). XX // AC C0029 XX ID runt XX DT 16.10.1997 (created); ewi. DT 04.05.1998 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL runt homology domain XX CC The members of this transcription factor class have been identified on the CC basis of their homology to a defined region within the Drosophila protein CC Runt. The runt domain is part of the DNA-binding domain of these factors. CC It consists mainly of beta-strands, does not contain alpha-helical regions CC and seems to be most similar to the palm domain found in DNA polymerase CC beta (rat). XX BF T01067; AML1; Species: human, Homo sapiens. BF T02444; AML1; Species: rat, Rattus norvegicus. BF T02457; AML1; Species: gibbon ape, Hylobates lar. BF T02256; AML1a; Species: human, Homo sapiens. BF T02245; AML1b; Species: human, Homo sapiens. BF T02246; AML1c; Species: human, Homo sapiens. BF T02220; AML1DeltaN; Species: human, Homo sapiens. BF T02223; AML2; Species: human, Homo sapiens. BF T02281; AML3; Species: human, Homo sapiens. BF T02441; AML3; Species: rat, Rattus norvegicus. BF T03983; AML3a; Species: human, Homo sapiens. BF T03984; AML3b; Species: human, Homo sapiens. BF T02253; Ch-runtB2; Species: chick, Gallus gallus. BF T02523; HeRunt-1; Species: sea urchin, Heliocidaris erythrogramma. BF T02219; Lz; Species: fruit fly, Drosophila melanogaster. BF T02266; Osf2; Species: mouse, Mus musculus. BF T00683; PEBP2; Species: mouse, Mus musculus. BF T01061; PEBP2alpha; Species: mouse, Mus musculus. BF T02459; PEBP2alpha; Species: human, Homo sapiens. BF T02318; PEBP2alphaA/til-1; Species: mouse, Mus musculus. BF T02320; PEBP2alphaA/til-1 (Y); Species: mouse, Mus musculus. BF T02319; PEBP2alphaA/til-1(U); Species: mouse, Mus musculus. BF T01062; PEBP2alphaA1; Species: mouse, Mus musculus. BF T01063; PEBP2alphaA2; Species: mouse, Mus musculus. BF T02235; PEBP2alphaB1; Species: mouse, Mus musculus. BF T02241; PEBP2alphaB2; Species: mouse, Mus musculus. BF T01066; runt; Species: fruit fly, Drosophila melanogaster. BF T02633; runt; Species: fruit fly, Drosophila pseudoobscura. BF T02634; runt; Species: fruit fly, Drosophila virilis. BF T02521; SpRunt-1; Species: sea urchin, Strongylocentrotus purpuratus. BF T02522; Xaml; Species: clawed frog, Xenopus laevis. XX RN [1] RX MEDLINE; 98202566. RA Levanon D. Eisenstein M. Groner Y. RT Site-directed mutagenesis supports a three-dimensional model of the runt RT domain RL J. Mol. Biol. 277:509-512 (1998). XX // AC C0030 XX ID histone fold XX DT 16.10.1997 (created); ewi. DT 16.10.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL histone fold XX CC The histone fold has been identified in the core histone molecules as CC DNA-binding and dimerization motif and has subsequently been found in CC several sequence-specifically binding transcription factors. It comprises CC an alpha-helix (11 residues), a short loop and beta-strand, a long CC alpha-helix (27 residues), another short loop and beta-strand, and another CC alpha-helix (11 residues). It may have been arosen by tandem duplication of CC a single helix-strand-helix (HSH) structural motif. Within histone CC molecules, the C-terminal HSH2 motif appears to enter more protein-protein CC contacts than HSH1, while both HSH motifs contact the DNA. XX BF T00087; CBF-A; Species: rat, Rattus norvegicus. BF T01595; CBF-C; Species: rat, Rattus norvegicus. BF T00154; CP1A; Species: human, Homo sapiens. BF T02478; CP1C; Species: human, Homo sapiens. BF T00350; HAP3; Species: yeast, Saccharomyces cerevisiae. BF T01263; hap3; Species: fission yeast, Schizosaccharomyces pombe. BF T00616; NF-YB; Species: mouse, Mus musculus. BF T02477; NF-YC; Species: mouse, Mus musculus. BF T02125; TAF(II)40; Species: fruit fly, Drosophila melanogaster. BF T02124; TAF(II)60; Species: fruit fly, Drosophila melanogaster. BF T00818; TFIIB; Species: human, Homo sapiens. BF T02159; TFIIB; Species: rat, Rattus norvegicus. BF T02160; TFIIB; Species: clawed frog, Xenopus laevis. XX DR Prosite: PS00685. XX // AC C0031 XX ID GCM XX DT 27.11.1997 (created); ewi. DT 27.11.1997 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL glial cells missing XX CC Within the N-terminal parts of Drosophila GCM, human and mouse GCMa and CC murine GCMb, a region of about 150 AA was disclosed that exhibits a high CC degree of homology. This gcm-motif is responsible for DNA-binding. Within CC this motif, three regions of identity were discovered: A, 10 AA; B, 9 AA; CC C, 10 AA. Additionally, there are 7 conserved Cys and 4 conserved His CC residues scattered over the gcm-motif. XX BF T02302; GCM; Species: fruit fly, Drosophila melanogaster. BF T02306; GCMa; Species: human, Homo sapiens. BF T02307; GCMa; Species: mouse, Mus musculus. BF T02308; GCMb; Species: mouse, Mus musculus. XX RN [1] RX MEDLINE; 97121489. RA Akiyama Y. Hosoya T. Poole A. M. Hotta Y. RT The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals RL Proc. Natl. Acad. Sci. USA 93:14912-14916 (1996). XX // AC C0032 XX ID bHSH XX DT 10.06.1998 (created); ewi. DT 10.06.1998 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL basic region + helix-span-helix domain XX CC Examining human AP-2 as paradigm of this structural class, a DNA-contacting CC domain was identified which comprises several clusters of basic amino acid CC side chains. C-terminally adjacent to it, a dimerization domain was found CC which consists of two putative alpha-helices separated by a span of over 80 CC amino acids. This HSH dimerization domain can functionally replace the ZIP CC dimerization domain of c-Jun [1] XX BF T00034; AP-2; Species: rat, Rattus norvegicus. BF T00952; AP-2; Species: clawed frog, Xenopus laevis. BF T01142; AP-2; Species: chick, Gallus gallus. BF T00033; AP-2alpha; Species: mouse, Mus musculus. BF T02488; AP-2alpha isoform 2; Species: mouse, Mus musculus. BF T02489; AP-2alpha isoform 3; Species: mouse, Mus musculus. BF T02490; AP-2alpha isoform 4; Species: mouse, Mus musculus. BF T00035; AP-2alphaA; Species: human, Homo sapiens. BF T03336; AP-2alphaA; Species: fruit fly, Drosophila melanogaster. BF T02466; AP-2alphaB; Species: human, Homo sapiens. BF T02467; AP-2beta; Species: human, Homo sapiens. BF T02469; AP-2beta; Species: mouse, Mus musculus. BF T02468; AP-2gamma; Species: human, Homo sapiens. BF T02470; AP-2gamma; Species: mouse, Mus musculus. XX RN [1] RX MEDLINE; 91149909. RA Williams T. Tjian R. RT Characterization of a dimerization motif in AP-2 and its function in RT heterologous DNA-binding proteins RL Science 251:1067-1071 (1991). XX // AC C0033 XX ID bas XX DT 19.01.1999 (created); ewi. DT 19.01.1999 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL basic domain (superclass) XX CC Proteins belonging to this superfamily contact the DNA through a basic CC region which free in solution has a random structure, but becomes CC alpha-helically folded upon binding to DNA [4] [5] [2] [1] [3]. Most CC prominent classes of this group are the bZIP and bHLH proteins. There is no CC "consensus" motif for all basic domains of this superfamily. Even the basic CC regions of bZIP and bHLH factors diverge greatly, although their mode of CC interacting with the DNA is strictly homologous: A specific alpha-helical CC dimerization domain provides the linkage between two DNA-contacting basic CC regions which adopt helical conformation when their positively charged side CC chains are neutralized by the phosphate backbone of the DNA. XX RN [1] RX MEDLINE; 95011595. RA Ellenberger T. Fass D. Arnaud M. Harrison S. C. RT Crystal structure of transcription factor E47: E-box recognition by a basic RT region helix-loop-helix dimer RL Genes Dev. 8:970-980 (1994). RN [2] RX MEDLINE; 93241312. RA Ferre-D'Amare A. E. Prendergast G. C. Ziff E. B. Burley S. K. RT Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain RL Nature 363:38-45 (1993). RN [3] RX MEDLINE; 92188160. RA Anthony-Cahill S. J. Benfield P. A. Fairman R. Wasserman Z. R. Brenner S. RA L. Stafford III W. F. Altenbach C. Hubbell W. L. DeGrado W. F. RT Molecular characterization of helix-loop-helix peptides RL Science 255:979-983 (1992). RN [4] RX MEDLINE; 91015365. RA Patel L. Abate C. Curan T. RT Altered protein conformation on DNA binding by Fos and Jun RL Nature 347:572-574 (1990). RN [5] RX MEDLINE; 91015366. RA Weiss M. A. Ellenberger T. Wobbe C. R. Lee J. P. Harrison S. C. Struhl K. RT Folding transition in the DNA-binding domain of GCN4 on specific binding to RT DNA RL Nature 347:575-578 (1990). XX // AC C0034 XX ID zin XX DT 19.01.1999 (created); ewi. DT 19.01.1999 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL zinc finger (superclass) XX CC In polymerase III transcription factor TFIIIA, a repetitive pattern of CC cysteine and histidine residues was discovered and, together with the known CC zinc-dependence of TFIIIA, led to the model of "zinc fingers" of the CC Cys2His2 type [5] [1]. Shortly after, sequences coding for the estrogen CC receptor were cloned and revealed a somewhat similar arrangement of CC cysteine residues only (Cys4), with no additional homologies [2] [4]. CC Nevertheless, a zinc finger model was proposed for these factors as well CC and was subsequently proven, with a minor alteration in the Cys pattern CC [3]. In addition to these two large classes of zinc finger proteins, there CC are many factors revealing Cys4 zinc fingers of variable composition, such CC as the GATA-factors, some fungal regulators and adenovirus E1A. Finally, CC the yeast GAL4-like regulators are grouped together as Cys6 "zinc clusters". XX BF T03200; ASH1; Species: yeast, Saccharomyces cerevisiae. BF T03299; DST1; Species: yeast, Saccharomyces cerevisiae. BF T03424; GTS1; Species: yeast, Saccharomyces cerevisiae. BF T03998; HRT; Species: barley, Hordeum vulgare. BF T03979; LSD1; Species: thale cress, Arabidopsis thaliana. BF T04736; LUN-2; Species: human, Homo sapiens. BF T04941; Mel-18; Species: human, Homo sapiens. BF T03899; PEI1; Species: thale cress, Arabidopsis thaliana. BF T03930; PZF; Species: soybean, Glycine max. BF T03932; PZF; Species: Lotus japonicus. BF T03660; SPT4; Species: yeast, Saccharomyces cerevisiae. BF T03007; TFB3; Species: yeast, Saccharomyces cerevisiae. BF T04945; TIF1a; Species: human, Homo sapiens. BF T04946; TIF1g; Species: human, Homo sapiens. BF T03684; TIS11; Species: yeast, Saccharomyces cerevisiae. BF T04145; WSTF; Species: human, Homo sapiens. BF T04766; ZPT2-1; Species: alfalfa, Medicago sativa. XX RN [1] RX MEDLINE; 89052664. RA Severne Y. Wieland S. Schaffner W. Rusconi S. RT Metal binding 'finger' structures in the glucocorticoid receptor defined by RT site-dierected mutagenesis RL EMBO J. 7:2503-2508 (1988). RN [2] RX MEDLINE; 86247578. RA Krust A. Green S. Argos P. Kumar V. Walter P. Bornert J.-M. Chambon P. RT The chicken oestrogen receptor sequence: homology with v-erbA and the human RT oestrogen and glucocorticoid receptors RL EMBO J. 5:891-897 (1986). RN [3] RX MEDLINE; 87053863. RA Kumar V. Green S. Staub A. Chambon P. RT Localization of the oestradiol-binding and putative DNA-binding domains of RT the human oestrogen receptor RL EMBO J. 5:2231-2236 (1986). RN [4] RX MEDLINE; 85284956. RA Miller J. McLachlan A. D. Klug A. RT Repetitive zinc-binding domains in the protein transcription factor IIIA RT from Xenopus oocytes RL EMBO J. 4:1609-1614 (1985). RN [5] RX MEDLINE; 84061844. RA Hanas J. S. Hazuda D. J. Bogenhagen D. F. Wu F. Y.-H. Wu C.-W. RT Xenopus transcription factor A requires zinc for binding to the 5 S RNA gene RL J. Biol. Chem. 258:14120-14125 (1983). XX // AC C0035 XX ID hel XX DT 19.01.1999 (created); ewi. DT 19.01.1999 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL helix-turn-helix (superclass) XX CC The helix-turn-helix superclass is a particularly large and heterogeneous CC family of transcription factors. Their DNA-binding motif appeared very CC early during evolution since it is found in prokaryotic and bacteriophage CC regulators as well as in mammalian transcriptional activators and CC repressors [3] [1] [2]. Presumably due to this property, most of them CC fulfil elementary functions in eukaryotes such as developmental regulation CC and determination of differentiation processes. In general, they comprise a CC DNA-recognition helix which inserts into the major DNA groove, another one CC which exerts unspecific stabilizing backbone interactions, and in most CC cases additional helices which help to stabilize the overall structure of CC the DNA-binding module. XX RN [1] RX MEDLINE; 84245843. RA Laughon A. Scott M. P. RT Sequence of a Drosophila segmentation gene: protein structure homology with RT DNA-binding proteins RL Nature 310:25-31 (1984). RN [2] RX MEDLINE; 84245855. RA Shepherd J. C. W. McGinnis W. Carrasco A. E. Robertis E. M. Gehring W. J. RT Fly and frog homeo domains show homologies with yeast mating typre RT regulatory proteins RL Nature 310:70-71 (1984). RN [3] RX MEDLINE; 84305754. RA Pabo C. O. Sauer R. T. RT Protein-DNA recognition RL Annu. Rev. Biochem. 53:293-321 (1984). XX // AC C0036 XX ID bet XX DT 19.01.1999 (created); ewi. DT 19.01.2000 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL beta-scaffold factors with minor groove contacts (superclass) XX CC "Non-transitive" superclass comprising several transcription factor classes CC for which it is difficult to define one common characteristic, but for CC which a series of characteristics can be listed, each one being shared by CC many but in no case by all of them. Among these characteristics are: CC "embracing" the DNA, DNA-bending/ kinking, comprising a beta-scaffold CC structure, binding the DNA through loops and/or extended regions, exerting CC minor groove contacts. Most of these DNA-binding domains comprise a more or CC less extended scaffold of beta-strands (beta-barrel, beta-sandwich, CC beta-sheet) which serves as a structural template to expose DNA-contacting CC secondary structure elements, be it alpha-helices, loops, or beta-strands CC themselves. These factors make extensive DNA-contacts either by embracing CC the DNA for at least half a turn, as was shown for a member of the CC Rel-class [3] [4], for p53 multimers [6], for TBP [6] [9] [8] and for HMG CC domains [7] [5], or wrap the DNA around the protein core. The latter was CC shown for a MADS-box factor [2] and for the viral regulator E2 [10]. Many CC of these factors have in common that they bind to A/T-rich cores with CC C/G-rich flanks, the central interactions made up by minor groove contacts. CC In the case of the Rel protein NF-6B p50, this central minor groove contact CC depends on the precise architecture of the binding site [3] [4]. These CC minor groove interactions with the DNA give rise to drastic distortions of CC the double helix, with the possible exception of the Rel class. XX RN [1] RX MEDLINE; 95364921. RA Pellegrini L. Tan S. Richmond T. J. RT Structure of serum response factor core bound to DNA RL Nature 376:490-498 (1995). RN [2] RX MEDLINE; 95379976. RA Love J. J. Li X. Case D. A. Giese K. Grosschedl R. Wright P. E. RT Structural basis for DNA bending by the architectural transcription factor RT LEF-1 RL Nature 376:791-795 (1995). RN [3] RX MEDLINE; 95132005. RA Ghosh G. van Duyne G. Ghosh S. Sigler P. B. RT Structure of NF-kappaB p50 homodimer bound to a kappaB site RL Nature 373:303-310 (1995). RN [4] RX MEDLINE; 95132006. RA Mueller C. W. Rey F. A. Sodeoka M. Verdine G. L. Harrison S. C. RT Structure of the NF-kappaB p50 homodimer bound to DNA RL Nature 373:311-317 (1995). RN [5] RX MEDLINE; 95292338. RA Werner M. H. Huth J. R. Gronenborn A. M. Clore G. M. RT Molecular basis of human 46X,Y sex reversal revealed from the RT three-dimensional solution structure of the human SRY-DNA complex RL Cell 81:705-714 (1995). RN [6] RX MEDLINE; 94294806. RA Cho Y. Gorina S. Jeffrey P. D. Pavletich N. P. RT Crystal structure of a p53 tumor suppressor-DNA complex: Understanding RT tumorigenic mutations RL Science 265:346-355 (1994). RN [7] RX MEDLINE; 94019790. RA Kim J. L. Nikolov D. B. Burley S. K. RT Co-crystal structure of TBP recognizing the minor groove of a TATA element RL Nature 365:520-527 (1993). RN [8] RX MEDLINE; 94019789. RA Kim Y. Geiger J. H. Hahn S. Sigler P. B. RT Crystal structure of a yeast TBP/TATA-box complex RL Nature 265:512-520 (1993). RN [9] RX MEDLINE; 93063314. RA Nikolov D. B. Hu S. H. Lin J. Gasch A. Hoffmann A. Horikoshi M. Chua N. H. RA Roeder R. G. Burley S. K. RT Crystal structure of TFIID TATA-box binding protein RL Nature 360:40-46 (1992). RN [10] RX MEDLINE; 93024918. RA Hegde R. S. Grossman S. R. Laimins L. A. Sigler P. B. RT Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding RT domain bound to its DNA target RL Nature 359:505-12 (1992). XX // AC C0037 XX ID AP2 XX DT 17.02.1999 (created); ewi. DT 17.02.1999 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL APETALA2/EREBP-like factors, AP2 domain, ERF domain XX CC The factors belonging to this class share a homology domain with the A. CC thaliana transcription factor APETALA2 (AP2) [3] [2]. The homolog of this CC domain in the EREBP factors has been shown to mediate DNA-binding [4] [1]. CC It comprises an N-terminal basic and hydrophilic YRG element and a CC C-terminal RAYD element, both of which being variably spaced by 1-15 amino CC acid residues [3]. The RAYD element contains a predicted amphiphilic CC alpha-helix [3]. AP2- and EREBP-related proteins form two distinct families CC within this class, many of the AP2 family factors harbouring two AP2 CC domains [2]. Up to now, the AP2 class comprises only transcription factors CC of higher plants. XX BF T02642; ABI4; Species: thale cress, Arabidopsis thaliana. BF T02639; ANT; Species: thale cress, Arabidopsis thaliana. BF T01774; AP2; Species: thale cress, Arabidopsis thaliana. BF T02636; CBF1; Species: thale cress, Arabidopsis thaliana. BF T04824; CBF2; Species: thale cress, Arabidopsis thaliana. BF T04823; CBF3; Species: thale cress, Arabidopsis thaliana. BF T02643; DREB1A; Species: thale cress, Arabidopsis thaliana. BF T02645; DREB1C; Species: thale cress, Arabidopsis thaliana. BF T02646; DREB2A; Species: thale cress, Arabidopsis thaliana. BF T02647; DREB2B; Species: thale cress, Arabidopsis thaliana. BF T02658; EBP; Species: thale cress, Arabidopsis thaliana. BF T04633; ERF-1; Species: thale cress, Arabidopsis thaliana. BF T04634; ERF-2; Species: thale cress, Arabidopsis thaliana. BF T04635; ERF-3; Species: thale cress, Arabidopsis thaliana. BF T04636; ERF-4; Species: thale cress, Arabidopsis thaliana. BF T04637; ERF-5; Species: thale cress, Arabidopsis thaliana. BF T02649; ERF1; Species: thale cress, Arabidopsis thaliana. BF T02653; ERF1; Species: tobacco, Nicotiana tabacum. BF T02654; ERF2; Species: tobacco, Nicotiana tabacum. BF T02655; ERF3; Species: tobacco, Nicotiana tabacum. BF T02656; ERF4; Species: tobacco, Nicotiana tabacum. BF T02640; Gl15; Species: maize, Zea mays. BF T02657; IDS1; Species: maize, Zea mays. BF T04748; ORCA1; Species: Catharanthus roseus, Madagascar periwinkle. BF T04749; ORCA2; Species: Catharanthus roseus, Madagascar periwinkle. BF T04751; ORCA3; Species: Catharanthus roseus, Madagascar periwinkle. BF T04715; Pti4; Species: tomato, Lycopersicon esculentum. BF T04716; Pti5; Species: tomato, Lycopersicon esculentum. BF T04717; Pti6; Species: tomato, Lycopersicon esculentum. BF T02660; RAP2.5; Species: thale cress, Arabidopsis thaliana. BF T02637; RAV1; Species: thale cress, Arabidopsis thaliana. BF T02638; RAV2; Species: thale cress, Arabidopsis thaliana. BF T04804; TEIL; Species: tobacco, Nicotiana tabacum. BF T02641; TINY; Species: thale cress, Arabidopsis thaliana. XX RN [1] RX MEDLINE; 98434603. RA Hao D. Ohme-Takagi M. Sarai A. RT Unique mode of GCC box recognition by the DNA-binding domain of RT ethylene-responsive element-binding factor (ERF domain) in plant RL J. Biol. Chem. 273:26857-26861 (1998). RN [2] RX MEDLINE; 98349801. RA Riechmann J. L. Meyerowitz E. M. RT The AP2/EREBP family of plant transcription factors RL Biol. Chem. Hoppe Seyler 379:633-646 (1998). RN [3] RX MEDLINE; 97338147. RA Okamuro J. K. Caster B. Villaroel R. van Montagu M. Jofuku K. D. RT The AP2 domain of APETALA2 defines a large new family of DNA binding RT proteins in Arabidopsis RL Proc. Natl. Acad. Sci. USA 94:7076-7081 (1997). RN [4] RX MEDLINE; 95276459. RA Ohme-Takagi M. Shinshi H. RT Ethylene-inducible DNA binding proteins that interact with an ethylene RT responsive element RL Plant Cell 7:173-182 (1995). XX // AC C0038 XX ID Dof XX DT 21.04.1999 (created); ewi. DT 21.04.1999 (updated); ewi. CO Copyright (C), Biobase GmbH. XX CL DNA-binding with One Finger XX CC A single zinc finger motif of C4 type comprising 4 cysteine residues which CC presumably coordinate one zinc ion [4]; the one zinc finger motif appears CC to be necessary for DNA-binding [3]; a fifth cysteine residue in the CC characteristically long zinc finger loop may have negative regulatory CC importance [2]; also called MOA (MNB1a, OBP1, and AOBP) motif [5] XX BF T02700; AOBP1; Species: winter squash, Cucurbita maxima. BF T02695; BBF1; Species: tobacco, Nicotiana tabacum. BF T02696; BBF2a; Species: tobacco, Nicotiana tabacum. BF T02697; BBF2b; Species: tobacco, Nicotiana tabacum. BF T02698; BBF3; Species: tobacco, Nicotiana tabacum. BF T02699; BBFa; Species: thale cress, Arabidopsis thaliana. BF T02690; Dof2; Species: maize, Zea mays. BF T02691; Dof3; Species: maize, Zea mays. BF T01059; MNB1a; Species: maize, Zea mays, strain H84. BF T02694; OBP1; Species: thale cress, Arabidopsis thaliana. BF T04825; OBP2; Species: thale cress, Arabidopsis thaliana. BF T04826; OBP3; Species: thale cress, Arabidopsis thaliana. BF T02692; PBF; Species: maize, Zea mays. BF T02693; PBF; Species: barley, Hordeum vulgare. BF T02701; PBF; Species: wheat, Triticum aestivum. XX RN [1] RA Yanagisawa S. Schmidt R. J. RT Diversity and similarity among recognition sequences of Dof transcription RT factors RL Plant J. 17:209-214 (1999). RN [2] RX MEDLINE; 98351835. RA Shimofurutani N. Kisu Y. Suzuki M. Esaka M. RT Functional analyses of the Dof domain, a zinc finger DNA-binding domain, in RT a pumpkin DNA-binding protein AOBP RL FEBS Lett. 430:251-256 (1998). RN [3] RX MEDLINE; 96367665. RA de Paolis A. Sabatini S. de Pascalis L. Costantino P. Capone I. RT A rolB regulatory factor belongs to a new class of single zinc finger plant RT proteins RL Plant J. 10:215-223 (1996). RN [4] RA Yanagisawa S. RT A novel DNA-binding domain that may form a single zinc finger motif RL Nucleic Acids Res. 23:3403-3410 (1995). RN [5] RX MEDLINE; 96351937. RA Zhang B. Chen W. Foley R. C. Buttner M. Singh K. B. RT Interactions between distinct types of DNA binding proteins enhance binding RT to ocs element promoter sequences RL Plant Cell 7:2241-2252 (1995). XX // AC C0039 XX ID STAT XX DT 24.11.1999 (created); ewi. CO Copyright (C), Biobase GmbH. XX CL signal transducers and activators of transcription XX BF T04075; dstA; Species: slime mould, Dictyostelium discoideum. BF T04683; STAT5A; Species: human, Homo sapiens. BF T04684; STAT5B; Species: human, Homo sapiens. XX RN [1] RX MEDLINE; 98292180. RA Chen X. Vinkemeier U. Zhao Y. Jeruzalmi D. Darnell jr. J. E. Kuriyan J. RT Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA RL Cell 93:827-839 (1998). RN [2] RX MEDLINE; 98128033. RA Vinkemeier U. Moarefi I. Darnell jr. J. E. Kuriyan J. RT Structure of the amino-terminal protein interaction domain of STAT-4 RL Science 279:1048-1052 (1998). RN [3] RX MEDLINE; 98334373. RA Becker S. Groner B. Mueller C. W. RT Three-dimensional structure of the Stat3beta homodimer bound to DNA RL Nature 394:145-151 (1998). XX // AC C0040 XX ID WRKY XX DT 10.08.2000 (created); rge. DT 28.03.2001 (updated); rge. CO Copyright (C), Biobase GmbH. XX CL WRKY domain together with a novel zinc-finger-like motif XX CC The WRKY domain is defined by the conserved amino acid sequence WRKYGQK at CC its N-terminal end, together with a novel zinc-finger-like motif. All known CC WRKY proteins contain either one or two WRKY domains. They can be CC classified on the basis of both the number of WRKY domains and the features CC of their zinc-finger-like motif (C2-H2: C-X 4-5 -C-X 22-23 -H-X 1 -H; CC C2-HC: C-X 7 -C-X 23 -H-X 1-C). Because of the clear binding preference of CC all characterized WRKY proteins for the same DNA motif, it has been assumed CC that the WRKY domain, as their only conserved structural feature, CC constitutes a DNA-binding domain. The WRKY domain has sequence-specific CC DNA-binding activity [1]. XX BF T03726; ABF1; Species: wild oat, Avena fatua. BF T03727; ABF2; Species: wild oat, Avena fatua. BF T03975; SPF1; Species: Sweet potato, Ipomoea batatas. BF T03807; WIZZ; Species: tobacco, Nicotiana tabacum. BF T03718; WRKY1; Species: parsley, Petroselinum crispum (P. hortense). BF T03973; WRKY1; Species: tobacco, Nicotiana tabacum. BF T04725; WRKY18; Species: thale cress, Arabidopsis thaliana. BF T03719; WRKY2; Species: parsley, Petroselinum crispum (P. hortense). BF T03974; WRKY2; Species: tobacco, Nicotiana tabacum. BF T03720; WRKY3; Species: parsley, Petroselinum crispum (P. hortense). BF T03728; WRKY3; Species: tobacco, Nicotiana tabacum. BF T03805; WRKY4; Species: tobacco, Nicotiana tabacum. BF T03722; ZAP1; Species: thale cress, Arabidopsis thaliana. XX RN [1] RX MEDLINE; 20249261. RA Eulgem T. Rushton P. J. Robatzek S. Somssich I. E. RT The WRKY superfamily of plant transcription factors RL Trends Plant Sci. 5:199-206 (2000). XX // AC C0041 XX ID SMAD XX DT 04.10.2000 (created); dkl. DT 28.03.2001 (updated); dkl. CO Copyright (C), Biobase GmbH. XX CL SMA- and MAD (Mother against DPP) related proteins XX CC proteins with 2 MAD-homology domains at N- and C-terminal ends, which have CC been named MH1 and MH2, are independently folded structures [1]; the CC structure of the MH2 domain is a beta-sandwich with a 3-alpha-helix bundle CC at one end, and 3 large loops and an alpha-helix at the other end [1]; the CC loop-helix region of one subunit packs against the 3-alpha-helix bundle of CC another subunit [1]; base-specific DNA recognition of the MH1 domain bound CC to a GTCT motif is via an 11-amino acid beta-hairpin, which lies in the CC major groove of the DNA [1]; 3 classes of SMAD: Inhibitory SMADs CC (SMAD-6,SMAD-7), Receptor-regulated SMADs (SMAD-1, SMAD-2, SMAD-3, SMAD-5, CC SMAD-8), Common Mediator SMADs (SMAD-4, SMAD-4beta, SMAD-10) [1]. XX BF T04473; DAD; Species: fruit fly, Drosophila melanogaster. BF T04493; DAF-3; Species: Caenorhabditis elegans. BF T04496; DAF-8; Species: Caenorhabditis elegans. BF T04225; dSMAD-2; Species: fruit fly, Drosophila melanogaster. BF T04378; Mad; Species: fruit fly, Drosophila melanogaster. BF T04379; MEDEA (MED); Species: fruit fly, Drosophila melanogaster. BF T04382; MEDEA-B (MED); Species: fruit fly, Drosophila melanogaster. BF T04296; SMA-2; Species: Caenorhabditis elegans. BF T04298; SMA-3; Species: Caenorhabditis elegans. BF T04299; SMA-4; Species: Caenorhabditis elegans. BF T04227; SMAD (Daf-14); Species: Caenorhabditis elegans. BF T03885; SMAD-1; Species: human, Homo sapiens. BF T03888; SMAD-1; Species: quail, Coturnix coturnix. BF T03889; SMAD-1; Species: chick, Gallus gallus. BF T03890; SMAD-1; Species: zebra fish, Brachydanio rerio. BF T04253; SMAD-1; Species: Schistosoma mansoni. BF T04254; SMAD-1; Species: mouse, Mus musculus. BF T04429; SMAD-1; Species: rat, Rattus norvegicus. BF T04432; SMAD-1; Species: clawed frog, Xenopus laevis. BF T03886; SMAD-1.1; Species: clawed frog, Xenopus laevis. BF T03892; SMAD-10; Species: clawed frog, Xenopus laevis. BF T04095; SMAD-2; Species: human, Homo sapiens. BF T04150; SMAD-2; Species: zebra fish, Brachydanio rerio. BF T04229; SMAD-2; Species: Schistosoma mansoni. BF T04232; SMAD-2; Species: rat, Rattus norvegicus. BF T04247; SMAD-2; Species: chick, Gallus gallus. BF T04273; SMAD-2; Species: mouse, Mus musculus. BF T04433; SMAD-2; Species: clawed frog, Xenopus laevis. BF T04442; SMAD-2 (437 AA); Species: human, Homo sapiens. BF T04096; SMAD-3; Species: human, Homo sapiens. BF T04149; SMAD-3; Species: zebra fish, Brachydanio rerio. BF T04210; SMAD-3; Species: mouse, Mus musculus. BF T04248; SMAD-3; Species: chick, Gallus gallus. BF T04251; SMAD-3; Species: domestic pig, Sus scrofa. BF T04431; SMAD-3; Species: rat, Rattus norvegicus. BF T03882; SMAD-4; Species: rat, Rattus norvegicus. BF T03884; SMAD-4; Species: zebra fish, Brachydanio rerio. BF T04252; SMAD-4; Species: domestic pig, Sus scrofa. BF T04292; SMAD-4; Species: human, Homo sapiens. BF T04554; SMAD-4 delta 3; Species: human, Homo sapiens. BF T04555; SMAD-4 delta 4; Species: human, Homo sapiens. BF T04559; SMAD-4 delta 4-6; Species: human, Homo sapiens. BF T04560; SMAD-4 delta 4-7; Species: human, Homo sapiens. BF T04558; SMAD-4 delta 5-6; Species: human, Homo sapiens. BF T04557; SMAD-4 delta 6; Species: human, Homo sapiens. BF T04153; SMAD-4alpha; Species: clawed frog, Xenopus laevis. BF T04154; SMAD-4beta; Species: clawed frog, Xenopus laevis. BF T04152; SMAD-5; Species: zebra fish, Brachydanio rerio. BF T04213; SMAD-5; Species: mouse, Mus musculus. BF T04222; SMAD-5; Species: human, Homo sapiens. BF T04235; SMAD-5; Species: rat, Rattus norvegicus. BF T04245; SMAD-5; Species: chick, Gallus gallus. BF T04295; SMAD-5; Species: clawed frog, Xenopus laevis. BF T04159; SMAD-6; Species: clawed frog, Xenopus laevis. BF T04220; SMAD-6; Species: human, Homo sapiens. BF T04236; SMAD-6; Species: mouse, Mus musculus. BF T04246; SMAD-6; Species: chick, Gallus gallus. BF T04156; SMAD-7; Species: clawed frog, Xenopus laevis. BF T04217; SMAD-7; Species: human, Homo sapiens. BF T04234; SMAD-7; Species: mouse, Mus musculus. BF T04244; SMAD-7; Species: rat, Rattus norvegicus. BF T04249; SMAD-7; Species: chick, Gallus gallus. BF T04215; SMAD-8; Species: mouse, Mus musculus. BF T04238; SMAD-8; Species: rat, Rattus norvegicus. BF T04250; SMAD-8; Species: chick, Gallus gallus. BF T04464; SMAD-8; Species: clawed frog, Xenopus laevis. BF T04230; SMAD1/5; Species: sea squirt, Halocynthia roretzi. XX RN [1] RX MEDLINE; 20073750. RA Hill C. S. RT The SMADs RL Int. J. Biochem. Cell Biol. 31:1249-1254 (1999). XX // AC C0042 XX ID homeo-PHD XX DT 27.11.2000 (created); rge. DT 28.03.2001 (updated); rge. CO Copyright (C), Biobase GmbH. XX CL PHD finger XX CC PHD finger proteins are defined by the presence of a cysteine-rich region CC N-terminal to the homeodomain. The consensus sequence for this region is CC C-X2-C-X13-C-X3-C-X4-H-X2-C-X18-C-P-X-C-X-C and it has been postulated that CC it may function as a domain for protein-protein interactions, as a redox CC sensitive sensor for environmental signals, or a sequence required for CC specific DNA binding by the protein [2]. Transcriptional activation is a CC common feature of PHD fingers, but together with an adjacent leucine zipper CC transcriptional activation of PHD fingers appears to be silent [1]. XX BF T04733; Alfin1; Species: alfalfa, Medicago sativa. BF T04111; HAT3.1; Species: thale cress, Arabidopsis thaliana. BF T04108; PRHA; Species: thale cress, Arabidopsis thaliana. BF T04105; PRHP; Species: parsley, Petroselinum crispum (P. hortense). BF T04738; SHL; Species: thale cress, Arabidopsis thaliana. BF T00922; ZmHox1a; Species: maize, Zea mays. BF T04101; ZmHox1b; Species: maize, Zea mays. BF T04102; ZmHox2a; Species: maize, Zea mays. BF T04104; ZmHox2b; Species: maize, Zea mays. XX RN [1] RX MEDLINE; 20440398. RA Halbach T. Scheer N. Werr W. RT Transcriptional activation by the PHD finger is inhibited through an RT adjacent leucine zipper that binds 14-3-3 proteins RL Nucleic Acids Res. 28:3542-3550 (2000). RN [2] RX MEDLINE; 98440131. RA Chan R. L. Gago G. M. Palena C. M. Gonzalez D. H. RT Homeoboxes in plant development RL Biochim. Biophys. Acta 1442:1-19 (1998). XX // AC C0043 XX ID BED finger XX DT 07.02.2001 (created); rge. DT 28.03.2001 (updated); rge. CO Copyright (C), Biobase GmbH. XX CL BED finger XX CC The BED finger which was named after the drosophila proteins BEAF and DREF, CC is found in one or more copies in cellular regulatory factors and CC transposases from plants, animals and fungi. The BED finger is an about 50 CC to 60 amino acid residues domain that contains a characteristic motif with CC two highly conserved aromatic positions, as well as a shared pattern of CC cysteines and histidines that is predicted to form a zinc finger CC (C-X2-C-XN-H-X3-5-H/C). As diverse BED fingers are able to bind DNA, it has CC been suggested that DNA-binding is the general function of this domain. XX BF T04306; 3AF1; Species: tobacco, Nicotiana tabacum. BF T04321; BEAF-32A; Species: fruit fly, Drosophila melanogaster. BF T04322; BEAF-32B; Species: fruit fly, Drosophila melanogaster. BF T04307; dpy-20; Species: Caenorhabditis elegans. BF T04319; dpy-20; Species: Caenorhabditis briggsae. BF T04324; DREF; Species: fruit fly, Drosophila melanogaster. BF T04339; DREF; Species: fruit fly, Drosophila virilis. BF T04960; KLF7; Species: human, Homo sapiens. XX DR Prosite: PS50808. XX RN [1] RX MEDLINE; 20446300. RA Aravind L. RT The BED finger, a novel DNA-binding domain in RT chromatin-boundary-element-binding proteins and transposases RL Trends Biochem. Sci. 25:421-423 (2000). XX // AC C0044 XX ID T-box XX DT 21.02.2001 (created); rio. DT 19.04.2001 (updated); rio. CO Copyright (C), Biobase GmbH. XX CL T domain, T-box proteins XX CC The T domain has originally been discovered in Brachyury (T) the founder CC member of the T-box familiy. It encodes a DNA binding domain of about 180 CC amino acids. X-ray analysis of the T domain showed that it binds as a dimer CC to a 20 nucleotide partially palindromic sequence. A new type of specific CC DNA contact is seen, in which a carboxy-terminal helix is deeply embedded CC into an enlarged minor groove without bending the DNA. XX BF T01526; Brachyury; Species: mouse, Mus musculus. BF T04947; Brachyury; Species: human, Homo sapiens. BF T04415; ET; Species: clawed frog, Xenopus laevis. BF T04412; H15; Species: fruit fly, Drosophila melanogaster. BF T04948; T-bet; Species: human, Homo sapiens. BF T04950; Tbr-1; Species: human, Homo sapiens. BF T04395; TBR2; Species: human, Homo sapiens. BF T04447; tbx-11; Species: Caenorhabditis elegans. BF T04410; tbx-12; Species: Caenorhabditis elegans. BF T04448; tbx-17; Species: Caenorhabditis elegans. BF T04449; tbx-18; Species: Caenorhabditis elegans. BF T04406; tbx-2; Species: Caenorhabditis elegans. BF T04407; tbx-7; Species: Caenorhabditis elegans. BF T04404; tbx-8; Species: Caenorhabditis elegans. BF T04409; tbx-9; Species: Caenorhabditis elegans. BF T04405; Tbx1; Species: mouse, Mus musculus. BF T04402; TBX18; Species: human, Homo sapiens. BF T04418; Tbx18; Species: mouse, Mus musculus. BF T04403; TBX19; Species: human, Homo sapiens. BF T04352; TBX1A; Species: human, Homo sapiens. BF T04354; TBX1B; Species: human, Homo sapiens. BF T04351; TBX2; Species: human, Homo sapiens. BF T04358; Tbx2; Species: mouse, Mus musculus. BF T04419; Tbx2; Species: clawed frog, Xenopus laevis. BF T04424; Tbx20; Species: mouse, Mus musculus. BF T04425; TBX20; Species: human, Homo sapiens. BF T04949; Tbx22; Species: human, Homo sapiens. BF T04359; Tbx3; Species: mouse, Mus musculus. BF T04420; Tbx3; Species: clawed frog, Xenopus laevis. BF T04413; TBX3 (722 AA); Species: human, Homo sapiens. BF T04414; TBX3 (742 AA); Species: human, Homo sapiens. BF T04349; TBX4; Species: human, Homo sapiens. BF T04350; Tbx4; Species: mouse, Mus musculus. BF T04421; Tbx4; Species: clawed frog, Xenopus laevis. BF T04347; Tbx5; Species: mouse, Mus musculus. BF T04348; Tbx5; Species: chick, Gallus gallus. BF T04422; Tbx5; Species: clawed frog, Xenopus laevis. BF T04345; TBX5 (long isoform); Species: human, Homo sapiens. BF T04423; Tbx5 (pseudovariant); Species: clawed frog, Xenopus laevis. BF T04346; TBX5 (short isoform); Species: human, Homo sapiens. BF T04396; TBX6; Species: human, Homo sapiens. BF T04417; Tbx6; Species: mouse, Mus musculus. XX DR Prosite: PS01283. XX RN [1] RX MEDLINE; 99221870. RA Smith J. RT T-box genes: what they do and how they do it RL Trends Genet. 15:154-158 (1999). RN [2] RX MEDLINE; 98164794. RA Papaioannou V. E. Silver L. M. RT The T-box gene family RL BioEssays 20:9-19 (1998). RN [3] RX MEDLINE; 98007980. RA Mueller C. W. Herrmann B. G. RT Crystallographic structure of the T domain-DNA complex of the Brachyury RT transcription factor RL Nature 389:884-888 (1997). XX // AC C0045 XX ID YABBY XX DT 20.04.2001 (created); rge. DT 20.04.2001 (updated); rge. CO Copyright (C), Biobase GmbH. XX CL zinc finger + HMG like domain XX CC The presence of the C2-C2 zinc finger domain and HMG-like domain is CC characteristic of the YABBY family of putative transcription factors. The CC HMG-like domain, designated the YABBY domain, has sequence similarity to CC DNA-binding domains of HMG transcription factors XX BF T04741; CRC; Species: thale cress, Arabidopsis thaliana. BF T04436; FIL; Species: thale cress, Arabidopsis thaliana. BF T04441; INO; Species: thale cress, Arabidopsis thaliana. XX // AC C0046 XX ID Trihelix XX DT 03.05.2001 (created); rge. DT 06.11.2001 (updated); rge. CO Copyright (C), Biobase GmbH. XX CL Trihelix motif XX CC proteins consist of two autonomous DNA-binding domains, one NH2-terminal CC and the other COOH-terminal, that discriminate with high resolution between CC the three GT motifs. A duplicated sequence of 75 amino acids, present once CC in each DNA-binding domain, appears likely to mediate DNA target element CC recognition. Each copy of this duplicated protein sequence is predicted to CC form three amphipathic alpha-helices separated from each other by two short CC loops [1] XX BF T04454; GT-1; Species: thale cress, Arabidopsis thaliana. BF T04284; GT-1a; Species: tobacco, Nicotiana tabacum. BF T04286; GT-1b; Species: tobacco, Nicotiana tabacum. BF T01097; GT-2; Species: rice, Oryza sativa. BF T04458; GT-2; Species: thale cress, Arabidopsis thaliana. BF T04459; GTL1; Species: thale cress, Arabidopsis thaliana. BF T04460; GTL2; Species: thale cress, Arabidopsis thaliana. XX RN [1] RX MEDLINE; 93011008. RA Dehesh K. Hung H. Tepperman J. M. Quail P. H. RT GT-2: a transcription factor with twin autonomous DNA-binding domains of RT closely related but different target sequence specificity RL EMBO J. 11:4131-4144 (1992). XX // AC C0047 XX ID GRAS XX DT 04.07.2001 (created); rge. CO Copyright (C), Biobase GmbH. XX BF T04778; GAI; Species: thale cress, Arabidopsis thaliana. BF T04777; GRS; Species: thale cress, Arabidopsis thaliana. BF T04561; SCR; Species: maize, Zea mays. BF T04770; SHR; Species: thale cress, Arabidopsis thaliana. XX RN [1] RX MEDLINE; 96339439. RA Di Laurenzio L. Wysocka-Diller J. Malamy J. E. Pysh L. Helariutta Y. RA Freshour G. Hahn M. G. Feldmann K. A. Benfey P. N. RT The SCARECROW gene regulates an asymmetric cell division that is essential RT for generating the radial organization of the Arabidopsis root RL Cell 86:423-433 (1996). XX // AC C0048 XX ID ARID XX DT 24.08.2001 (created); rio. DT 27.08.2001 (updated); rio. CO Copyright (C), Biobase GmbH. XX CL AT-rich interaction domain family XX CC Highly conserved DNA-binding domain that encompass 108-132 amino acids. The CC solution structure of the Mrf-2 binding domain contains six helices, two CC loops and a flexible C-terminus. In the DNA complex Mrf-2 contacts both the CC major and minor grooves. XX BF T04679; dri; Species: fruit fly, Drosophila melanogaster. BF T04867; DRIL1; Species: human, Homo sapiens. BF T04675; MRF-2; Species: human, Homo sapiens. XX RN [1] RX MEDLINE; 21371773. RA Zhu L. Hu J. Lin D. Whitson R. Itakura K. Chen Y. RT Dynamics of the mrf-2 dna-binding domain free and in complex with dna. RL Biochemistry 40:9142-9150 (2001). RN [2] RX MEDLINE; 99262098. RA Whitson R. H. Huang T. Itakura K. RT The novel Mrf-2 DNA-binding domain recognizes a five-base core sequence RT through major and minor-groove contacts RL Biochem. Biophys. Res. Commun. 258:326-331 (1999). RN [3] RX MEDLINE; 99023193. RA Yuan Y. C. Whitson R. H. Liu Q. Itakura K. Chen Y. RT A novel DNA-binding motif shares structural homology to DNA replication and RT repair nucleases and polymerases RL Nat. Struct. Biol. 5:959-964 (1998). XX // AC C0049 XX ID RING XX DT 21.09.2001 (created); rio. DT 21.09.2001 (updated); rio. CO Copyright (C), Biobase GmbH. XX CL RING finger XX CC The RING finger or C3HC4 finger is a zinc-binding domain that is found in CC proteins form plants to humans. It can be described in more detail as CC CX(2)CX(9-39)CX(1-3)HX(2-3)CX(2)CX(4-48)CX(2) where X can be any amino CC acid. Only a subset of this large family has been identified as CC transcription factors, they are also involved in various other molecular CC functions (e.g. signal transduction). RING-finger-containing proteins are CC often part of multi-protein-complexes and it appears that the RING is CC involved in mediating protein-protein interactions and not directly CC mediating binding to DNA. XX BF T04074; BRCA1; Species: human, Homo sapiens. BF T03933; COP1; Species: thale cress, Arabidopsis thaliana. BF T04734; LUN-1; Species: human, Homo sapiens. BF T03536; par-2; Species: Caenorhabditis elegans. BF T03531; RAD18; Species: yeast, Saccharomyces cerevisiae. BF T01689; Staf-50; Species: human, Homo sapiens. XX RN [1] RX MEDLINE; 96280420. RA Saurin A. J. Borden K. L. Boddy M. N. Freemont P. S. RT Does this have a familiar RING? RL Trends Genet. 21:208-214 (1996). XX // AC C0050 XX ID HSF XX DT 30.10.2001 (created); rge. DT 17.12.2001 (updated); rge. CO Copyright (C), Biobase GmbH. XX CL heat stress transcription factor XX CC modular structure with an N-terminal DNA binding domain characterized by a CC central helix-turn-helix motif, an adjacent domain with heptad hydrophobic CC repeats (HR-A/B) involved in oligomerization, a cluster of basic amino acid CC residues essential for nuclear import (NLS), and an acidic C-terminal CC activation domain [1] [2] XX BF T04394; HSF1; Species: thale cress, Arabidopsis thaliana. BF T04397; HSF3; Species: thale cress, Arabidopsis thaliana. BF T04399; HSF4; Species: thale cress, Arabidopsis thaliana. BF T04788; HsfA; Species: pea, Pisum sativum. BF T02033; HsfA1; Species: tomato, Lycopersicon esculentum. BF T02032; HsfA2; Species: tomato, Lycopersicon esculentum. BF T04839; HsfA3; Species: tomato, Lycopsersicon peruvianum. BF T02031; HsfB1; Species: tomato, Lycopsersicon peruvianum. XX RN [1] RX MEDLINE; 99088027. RA Morimoto R. I. RT Regulation of the heat shock transcriptional response: cross talk between a RT family of heat shock factors, molecular chaperones, and negative regulators RL Genes Dev. 12:3788-3796 (1998). RN [2] RX MEDLINE; 96244627. RA Wu C. RT Heat shock transcription factors: structure and regulation RL Annu. Rev. Cell Biol. 11:441-469 (1995). XX //