VV TRANSFAC FACTOR TABLE, Rel.3.2 26-06-1997 XX // AC T00001 XX ID T00001 XX DT 16.09.96 11:45:19 (created); ewi. DT 16.09.96 (updated); ewi. XX FA AAF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SF similar to GAF XX FF induced by interferon-alpha (15-30'), inhibited by 2-AP XX BS R02116; AAF$CONS; Quality: 6 BS R03064; HS$GBP_02; Quality: 6; human, Homo sapiens XX RN [1] RA Decker T., Lew D. J., Darnell J. E. RT Two distinct alpha-interferon-dependent signal transduction RT pathways may contribute to activation of transcription RT of the guanylate-binding protein gene RL Mol. Cell. Biol. 11:5147-5153 (1991). RN [2] RA Decker T., Lew D. J., Mirkowitch J., Darnell J. E. RT Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor RL EMBO J. 10:927-932 (1991). XX // AC T00002 XX ID T00002 XX DT 28.10.92 (created); ewi. DT 24.01.97 (updated); ewi. XX FA ACE2 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0001; CH; 2.3.3.0.1. XX SZ 770 AA; 86.6 kDa (gene) XX SQ MDNVVDPWYINPSGFAKDTQDEEYVQHHDNVNPTIPPPDNYILNNENDDGLDNLLGMDYY SQ NIDDLLTQELRDLDIPLVPSPKTGDGSSDKKNIDRTWNLGDENNKVSHYSKKSMSSHKRG SQ LSGTAIFGFLGHNKTLSISSLQQSILNMSKDPQPMELINELGNHNTVKNNNDDFDHIREN SQ DGENSYLSQVLLKQQEELRIALEKQKEVNEKLEKQLRDNQIQQEKLRKVLEEQEEVAQKL SQ VSGATNSNSKPGSPVILKTPAMQNGRMKDNAIIVTTNSANGGYQFPPPTLISPRMSNTSI SQ NGSPSRKYHRQRYPNKSPESNGLNLFSSNSGYLRDSELLSFSPQNYNLNLDGLTYNDHNN SQ TSDKNNNDKKNSTGDNIFRLFEKTSPGGLSISPRINGNSLRSPFLVGTDKSRDDRYAAGT SQ FTPRTQLSPIHKKRESVVSTVSTISQLQDDTEPIHMRNTQNPTLRNANALASSSVLPPIP SQ GSSNNTPIKNSLPQKHVFQHTPVKAPPKNGSNLAPLLNAPDLTDHQLEIKTPIRNNSHCE SQ VESYPQVPPVTHDIHKSPTLHSTSPLPDEIIPRTTPMKITKKPTTLPPGTIDQYVKELPD SQ KLFECLYPNCNKVFKRRYNIRSHIQTHLQDRPYSCDFPGCTKAFVRNHDLIRHKISHNAK SQ KYICPCGKRFNREDALMVHRSRMICTGGKKLEHSINKKLTSPKKSLLDSPHDTSPVKETI SQ ARDKDGSVLMKMEEQLRDDMRKHGLLDPPPSTAAHEQNSNRTLSNETDAL XX SC SwissProt #P21192 XX SF 3 zinc finger motifs XX FF cell cycle-regulated activator of metallothionein and chitinase genes XX DR EMBL: M55619; SCACE2(g). DR SwissProt: P21192; ACE2_YEAST. DR PIR: S12943; TWBYA2. XX RN [1] RA Dohrmann P. R., Butler G., Tamai K., Dorland S., Greene RA J. R., Thiele D. J., Stillman B. RT Parallel pathways of gene regulation: Homologous regulators RT SWI5 and ACE2 differentially control transcription of HO and chitinase RL Genes Dev. 6:93-104 (1992). RN [2] RA Butler G., Thiele D. J. RT ACE2, an activator of yeast metallothionein expression RT which is homologous to SWI5 RL Mol. Cell. Biol. 11:476-485 (1991). XX // AC T00003 XX ID T00003 XX DT 20.10.92 (created); ewi. DT 27.08.96 (updated); ewi. XX FA AS-C T3 XX SY Achaete-Scute T3; L'Sc; Lethal of Scute; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0010; bHLH; 1.2.3.0.1. XX SZ 257 AA; 29.0 kDa (gene) XX SQ MTSICSSKFQQQHYQLTNSNIFLLQHQHHHQTQQHQLIAPKIPLGTSQLQNMQQSQQSNV SQ GPMLSSQKKKFNYNNMPYGEQLPSVARRNARERNRVKQVNNGFVNLRQHLPQTVVNSLSN SQ GGRGSSKKLSKVDTLRIAVEYIRGLQDMLDDGTASSTRHIYNSADESSNDGSSYNDYNDS SQ LDSSQQFLTGATQSAQSRSYHSASPTPSYSGSEISGGGYIKQELQEQDLKFDSFDSFSDE SQ QPDDEELLDYISSWQEQ XX SC SwissProt #P09774 XX FT 87 95 basic region FT 96 146 helix-loop-helix domain FT 243 256 acidic region (6/14) XX SF heterodimerization required for efficient DNA-binding [1]; XX CP neuroectoderm [3]; CN neurons [3]; XX FF activator, involved in neurogenesis, presumably by FF controlling the segregation of different neural lineages FF from epidermal precursors [3], [5]; FF promotes development of sensory organ mother cells FF independently from the other AS-C genes [4]; FF mRNA accumulates at blastoderm stage; FF antagonized by emc [7]; XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00405; IEBP1; rat, Rattus norvegicus. IN T00674; E47; rat, Rattus norvegicus. IN T00675; E12; rat, Rattus norvegicus. IN T01034; Da; fruit fly, Drosophila melanogaster. IN T01787; E12; clawed frog, Xenopus laevis. IN T01788; E47; mouse, Mus musculus. XX BS R03719; DROME$AC_01; Quality: 6; fruit fly, Drosophila melanogaster BS R03718; DROME$HB_12; Quality: 6; fruit fly, Drosophila melanogaster BS R00883; MOUSE$IGKL_07; Quality: 6; mouse, Mus musculus BS R00884; MOUSE$IGKL_08; Quality: 6; mouse, Mus musculus BS R00885; MOUSE$IGKL_09; Quality: 6; mouse, Mus musculus XX DR EMBL: X12549; DMASCT3(g). DR SwissProt: P09774; AST3_DROME. DR PIR: S01165; S01165. DR Flybase: FBgn0002561; l(1)sc. XX RN [1] RA Cabrera C. V., Alonso M. C. RT Transcriptional activation by heterodimers of the RT achaete-scute and daughterless gene products of Drosophila RL EMBO J. 10:2965-2973 (1991). RN [2] RA Murre C., McCaw P. S., Vaessin H., Caudy M., Jan L. RA Y., Jan Y. N., Cabrera C. V., Buskin J. N., Hauschka RA S. D., Lassar A. B., Weintraub H., Baltimore D. RT Interactions between heterologous helix-loop-helix RT proteins generate complexes that bind specifically to a common DNA sequence RL Cell 58:537-544 (1989). RN [3] RA Cabrera C. V., Martinez-Arias A., Bate M. RT The expression of three members of the achaete-scute RT gene complex correlates with neuroblast segregation in Drosophila RL Cell 50:425-433 (1987). RN [4] RA Garcia-Bellido A. RT Genetic analysis of the achaete-scute system of Drosophila melanogaster RL Genetics 91:491-520 (1979). RN [5] RA Hinz U., Giebel B., Campos-Ortega J. A. RT The basic helix-loop-helix domain of Drosophila Lethal RT of Scute protein is sufficient for proneural function RT and activates neurogenic genes RL Cell 76:77-87 (1994). RN [6] RA Alonso L. G., Cabrera C. V. RT The achaete-scute gene complex of Drosophila melanogaster RT comprises four homologous genes RL EMBO J. 7:2585-2591 (1988). RN [7] RA Garrell J., Modolell J. RT The Drosophila extramacrochaetae locus, an antagonist RT of proneural genes that; like these genes; encodes RT a helix-loop-helix protein RL Cell 61:39-48 (1990). XX // AC T00004 XX ID T00004 XX DT 20.10.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA Sc XX SY AS-C T4; Achaete-Scute T4; Scute; Sis-b; Sisterless-b; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0010; bHLH; 1.2.3.0.2. XX SZ 345 AA; 38.1 kDa (gene) XX SQ MKNNNNTTKSTTMSSSVLSTNETFPTTINSATKIFRYQHIMPAPSPLIPGGNQNQPAGTM SQ PIKTRKYTPRGMALTRCSESVSSLSPGSSPAPYNVDQSQSVQRRNARERNRVKQVNNSFA SQ RLRQHIPQSIITDLTKGGGRGPHKKISKVDTLRIAVEYIRSLQDLVDDLNGGSNIGANNA SQ VTQLQLCLDESSSHSSSSSTCSSSGHNTYYQNRISVSPVQQQQQLQRQQFNHQPLTALSL SQ NTNLVGTSVPGGDAGCVSTSKNQQTCHSPTSSFNSSMSFDSGTYEGVPQQISTHLDRLDH SQ LDNELHTHSQLQLKFEPYEHFQLDEEDCTPDDEEILDYISLWQEQ XX SC SwissProt #P10084 XX FT 103 111 basic region FT 112 163 helix-loop-helix domain FT 191 204 serine-rich region (11/14) FT 220 233 glutamine-rich region (9/14) FT 324 337 acidic region (9/14) XX SF 5th Met codon revealing better match with Kozak rules SF would give rise a 274 AA peptide of 30.4 kDa [9]; SF heterodimerization with Da required for efficient DNA-binding [1], [8]; XX CP nervous system - proneural clusters of imaginal disks CN neurons [2]; XX FF (co-)regulator of neurogenesis, involved in segregation FF of neural lineages from epidermal precursors [9]; FF expressed in cells delimiting sensory mother cell areas [4]; FF one cell per group with highest Ac and Sc levels becomes FF a sensory mother cell [4]; FF directing the morphogen Dorsal to target genes in FF lateral regions of the embryo by cooperative DNA-binding [7]; FF numerator in the sex-determining X:A ratio; FF expression domains are first complementary to those FF of Ac, then identical due to mutual induction [5], [6]; FF antagonized and down-regulated by Emc [10], [4]; FF repressed by Hairy in a spatially and temporally different pattern [6]; XX IN T01034; Da; fruit fly, Drosophila melanogaster. XX BS R03719; DROME$AC_01; Quality: 6; fruit fly, Drosophila melanogaster BS R03718; DROME$HB_12; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: M17119; DMACS2(g). DR SwissProt: P10084; AST4_DROME. DR Flybase: FBgn0004170; sc. XX RN [1] RA Cabrera C. V., Alonso M. C. RT Transcriptional activation by heterodimers of the RT achaete-scute and daughterless gene products of Drosophila RL EMBO J. 10:2965-2973 (1991). RN [2] RA Cabrera C. V., Martinez-Arias A., Bate M. RT The expression of three members of the achaete-scute RT gene complex correlates with neuroblast segregation in Drosophila RL Cell 50:425-433 (1987). RN [3] RA Campuzano S., Carramolino L., Cabrera C. V., Ruiz-Gmez RA M., Villares R., Boronat A., Modolell J. RT Molecular genetics of the achaete-scute gene complex of D. Melanogaster RL Cell 40:327-338 (1985). RN [4] RA Cubas P., de Celis J.-F., Campuzano S., Modolell J. RT Proneural clusters of achaete-scute expression and RT the generation of sensory organs in the Drosophila imaginal wing disc RL Genes Dev. 5:996-1008 (1991). RN [5] RA Martinez C., Modolell J. RT Cross-regulatory interactions between the proneural RT achaete and scute genes of Drosophila RL Science 251:1485-1487 (1991). RN [6] RA Skeath J. B., Carroll S. B. RT Regulation of achaete-scute gene expression and sensory RT organ pattern formation in the Drosophila wing RL Genes Dev. 5:984-995 (1991). RN [7] RA Jiang J., Levine M. RT Binding affinities and cooperative interactions with RT bHLH activators delimit threshold responses to the dorsal gradient morphogen RL Cell 72:741-752 (1993). RN [8] RA Singson A., Leviten M. W., Bang A. G., Hua X. H., Posakony J. W. RT Direct downstream targets of proneural activators RT in the imaginal disc include genes involved in lateral inhibitory signaling RL Genes Dev. 8:2058-2071 (1994). RN [9] RA Villares R., Cabrera C. V. RT The achaete-scute gene complex of D. melanogaster: RT conserved domains in a subset of genes required for RT neurogenesis and their homology to myc RL Cell 50:415-424 (1987). RN [10] RA Ellis H. M., Spann D. R., Posakony J. W. RT extramacrochaetae, a negative regulator of sensory RT organ development in Drosophila, defines a new class RT of helix-loop-helix proteins RL Cell 61:27-38 (1990). XX // AC T00005 XX ID T00005 XX DT 20.10.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA Ac XX SY AS-C T5; Achaete; Achaete-Scute T5; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0010; bHLH; 1.2.3.0.3. XX SZ 201 AA; 22.7 kDa (gene) XX SQ MALGSENHSVFNDDEESSSAFNGPSVIRRNARERNRVKQVNNGFSQLRQHIPAAVIADLS SQ NGRRGIGPGANKKLSKVSTLKMAVEYIRRLQKVLHENDQQKQKQLHLQQQHLHFQQQQQH SQ QHLYAWHQELQLQSPTGSTSSCNSISSYCKPATSTIPGATPPNNFHTKLEASFEDYRNNS SQ CSSGTEDEDILDYISLWQDDL XX SC SwissProt #P10083 XX FT 91 133 glutamine-rich region (17/43) FT 28 36 basic region FT 37 91 helix-loop-helix domain FT 134 160 serine-/threonine-rich region (13/27) FT 186 200 acidic region (7/15) XX CP nervous system - proneural clusters of imaginal disks CN neurons [3]; XX FF (co-)regulator of neurogenesis, probably involved FF in segregation of neural lineages from epidermal precursor cells [11]; FF involved in sensory mother cell development [5], [10]; FF one cell per group of precursor cells with highest FF Ac and Sc levels becomes a sensory mother cell [5]; FF expression domains are first complementary to those FF of Ac, then identical due to mutual induction [6], [7]; FF antagonized and down-regulated by Emc [12], [5] through FF otherwise stimulatory E-box-like elements in the promoter [8]; FF repressed by Hairy in a spatially and temporally different pattern [7], [2]; XX IN T01034; Da; fruit fly, Drosophila melanogaster. IN T01652; HES-5; rat, Rattus norvegicus. XX BS R03719; DROME$AC_01; Quality: 6; fruit fly, Drosophila melanogaster BS R03718; DROME$HB_12; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: M17120; DMACS1(g). DR SwissProt: P10083; AST5_DROME. DR PIR: A43731; A43731. DR Flybase: FBgn0000022; ac. XX RN [1] RA Cabrera C. V., Alonso M. C. RT Transcriptional activation by heterodimers of the RT achaete-scute and daughterless gene products of Drosophila RL EMBO J. 10:2965-2973 (1991). RN [2] RA Van Doren M., Bailey A. M., Esnayra J., Ede K., Posakony J. W. RT Negative regulation of proneural gene activity: hairy RT is a direct transcriptional repressor of achaete RL Genes Dev. 8:2729-2742 (1994). RN [3] RA Cabrera C. V., Martinez-Arias A., Bate M. RT The expression of three members of the achaete-scute RT gene complex correlates with neuroblast segregation in Drosophila RL Cell 50:425-433 (1987). RN [4] RA Campuzano S., Carramolino L., Cabrera C. V., Ruiz-Gmez RA M., Villares R., Boronat A., Modolell J. RT Molecular genetics of the achaete-scute gene complex of D. Melanogaster RL Cell 40:327-338 (1985). RN [5] RA Cubas P., de Celis J.-F., Campuzano S., Modolell J. RT Proneural clusters of achaete-scute expression and RT the generation of sensory organs in the Drosophila imaginal wing disc RL Genes Dev. 5:996-1008 (1991). RN [6] RA Martinez C., Modolell J. RT Cross-regulatory interactions between the proneural RT achaete and scute genes of Drosophila RL Science 251:1485-1487 (1991). RN [7] RA Skeath J. B., Carroll S. B. RT Regulation of achaete-scute gene expression and sensory RT organ pattern formation in the Drosophila wing RL Genes Dev. 5:984-995 (1991). RN [8] RA Jiang J., Levine M. RT Binding affinities and cooperative interactions with RT bHLH activators delimit threshold responses to the dorsal gradient morphogen RL Cell 72:741-752 (1993). RN [9] RA Singson A., Leviten M. W., Bang A. G., Hua X. H., Posakony J. W. RT Direct downstream targets of proneural activators RT in the imaginal disc include genes involved in lateral inhibitory signaling RL Genes Dev. 8:2058-2071 (1994). RN [10] RA Ruiz-Gmez M., Ghysen A. RT The expression and role of a proneural gene, achaete, RT in the development of the larval nervous system of Drosophila RL EMBO J. 12:1121-1130 (1993). RN [11] RA Villares R., Cabrera C. V. RT The achaete-scute gene complex of D. melanogaster: RT conserved domains in a subset of genes required for RT neurogenesis and their homology to myc RL Cell 50:415-424 (1987). RN [12] RA Ellis H. M., Spann D. R., Posakony J. W. RT extramacrochaetae, a negative regulator of sensory RT organ development in Drosophila, defines a new class RT of helix-loop-helix proteins RL Cell 61:27-38 (1990). XX // AC T00006 XX ID T00006 XX DT 20.10.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA Ase XX SY AS-C T8; Achaete-Scute T8; Asense; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0010; bHLH; 1.2.3.0.4. XX SZ 486 AA; 53.2 kDa (gene) XX SQ MAALSFSPSPPPKENPKENPNPGIKTTLKPFGKITVHNVLSESGANALQQHIANQNTIIR SQ KIRDFGMLGAVQSAAASTTNTTPISSQRKRPLGESQKQNRHNQQNQQLSKTSVPAKKCKT SQ NKKLAVERPPKAGTISHPHKSQSDQSFGTPGRKGLPLPQAVARRNARERNRVKQVNNGFA SQ LLREKIPEEVSEAFEAQGAGRGASKKLSKVETLRMAVEYIRSLEKLLGFDFPPLNSQGNS SQ SGSGDDSFMFIKDEFDCLDEHFDDSLSNYEMDEQQTVQQTLSEDMLNPPQASDLLPSLTT SQ LNGLQYIRIPGTNTYQLLTTDLLGDLSHEQKLEETAASGQLSRSPVPQKVVRSPCSSPVS SQ PVASTELLLQTQTCATPLQQQVIKQEYVSTNISSSSNAQTSPQQQQQVQNLGSSPILPAF SQ YDQEPVSFYDNVVLPGFKKEFSDILQQDQPNNTTAGCLSDESMIDAIDWWEAHAPKSNGA SQ CTNLSV XX SC SwissProt #P09775 XX FT 163 171 basic region FT 172 224 helix-loop-helix domain FT 399 409 glutamine-rich region (7/11) FT 67 457 identical to 1-391 of ref. [4], [1]; XX SF different sequence due to some frameshifts within SF N- and C-terminal regions: 397 AA, 43.5 kDa [4], [1]; XX CP medio-lateral region of metameric band between ectoderm CP and mesoderm; neural precursors, peak at stages 10-11; CP primordia of somatogastric and optic lobes, presumptive CP procephalic lobe [4]; XX FF involved in regulation of neurogenesis [1], [2]; FF required for development of some sensory mother cells, FF e. g. those that give rise to recurved bristles of FF the anterior wing margin [2]; XX DR EMBL: X12550; DMASCT8(g). DR EMBL: X52892; DMASE(g). DR SwissProt: P09775; AST8_DROME. DR Flybase: FBgn0000137; ase. XX RN [1] RA Gonzalez F., Romani S., Cubas P., Modolell J., Campuzano S. RT Molecular analysis of the asense gene, a member of RT the achaete-scute complex of Drosophila melanogaster, RT and its novel role in optic lobe development RL EMBO J. 8:3553-3562 (1989). RN [2] RA Domģnguez M., Campuzano S. RT asense, a member of the Drosophila achaete-scute complex, RT is a proneural and neural differentiation gene RL EMBO J. 12:2049-2060 (1993). RN [3] RA Beamonte D., Modolell J. RT x RL Mol. Gen. Genet. 215:281-285 (1989). RN [4] RA Alonso L. G., Cabrera C. V. RT The achaete-scute gene complex of Drosophila melanogaster RT comprises four homologous genes RL EMBO J. 7:2585-2591 (1988). XX // AC T00007 XX ID T00007 XX DT 15.10.92 (created); ewi. DT 04.09.96 (updated); ewi. XX FA alphaA-CRYBP1 XX SY PRDII-BF1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; 2.3.4.0.5. XX SZ 2688 AA; 288.3 kDa (gene) XX SQ MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKEVLEAGVKGTSESLKGVKRKKIVAENHLK SQ KIPKSPLRNPLQTKHKQNTEEPPFSVLPSASESHKKHNCVPAKQGRQFTKQNGETPGMTA SQ ESSESGDLVSPKKTSSPHQRSELRRWRSEGSDPTRLSGLDGQRDSSSSSSKARTDNSECS SQ SPCCSTTPPSYTSTAFDVLLKAMEPELSTLSQKGSSCAIKTEKLRPNKTVRSPSKLKNSS SQ LDAPNATSPDLVVESPCPPCTSYPVHVASTQKSEQVAAQCVSHLYSSQDHLVPKLSQQNQ SQ QLPGHLGFTGSLTNLHTLESTKLEPIYNTAVTSTVGLTSPSTRTQVTPPHQQMDSVSPLS SQ VSPASSTQSPPGPIYSSAHVASVVSQSVEQMCSLLLRDQKPKKQGKYICEYCNRACAKPS SQ VLLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKLGLVLQPEAGGLFLSQEC SQ PKALSVHSDIEDSGESDEEGLADGRQNNPCVKDLQPVQTMKTVSNPESLPKLIPSNSDHV SQ VRGFSSQDRPSDSQAPTELPKVVVHPVSMPPLKTDCLQVANPNPELPSPQSPRDLHVASI SQ LSHSASVSSLEMDESCHQKGDVIQSEGKPDSHSGTAHAQLQRQQATEDPQEQQGKLLLSP SQ RSLGSTDSGYFSRSESADQAVSPPTPFARTFPTMDPDPAKNGGAPGPRISAPAPSALATG SQ EKSSVVTGQMRPPLATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKS SQ YIFKDSFQFDLKPMGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTT SQ GYSAIPANIIPPPPSLRGSQSFDDKIGTLYDDVFVSGPNPSMPPSGHHRPLVRQAAVEDS SQ TASESHVPGSGQSVDESCQGCPSSSEAGPVQSKAAQTPHLEKKKSHQGRGTMFECETCRN SQ RYRKLENFENHKKFYCSELHGPKTKAAVREAEHGPAPGGAQPQVLHYRVAAPTAVWEQTP SQ QIRKRRKMKSVGDEEDLQPHESGRSPESADALQLQPVPGAAPSPSKHTSATAADQAHRGV SQ QLVARGPERALPLKQCPMVEQQLNAAAQDKMEVKRQGGGISVIQHTNSLSRPNSFDKPEP SQ LEGGITFSLQELGRTGMPGALKVIGMAPEEGHPPQDAMHQTALSHNLRGEPRESARKIPS SQ ERYVLGQPLRLVRQHNIQVPEILVTEEPDRDLEAQSHDEEKSEKFTWPQRSETLSKLPTE SQ KLPPKKKRLRLAEIEHSSTESSFESTLSRSLSRESSLSHASSFSASLDLEDISKVELAPK SQ IDFPSKAEFLLIPLGSNTLSVPGSHREMRRAASEQISCVPTLMEVSDFRSKSFDCGSIAP SQ SHVVPALVESQPSYSPSAVGGTAHVPLLERRRGPLIRQISLNIASDSHLSPGSAAALQTI SQ VLPSVNTVPFQAPRLPDMASADCPAHTVHPQALAKDLQAEISSSSSTDTFPPQQLFGAHL SQ LNKTNTSLSHQNTPLPLPVSAQGGKPDAAPTACVSSTGEGSFAPKYQLQCQAFTSDQGCS SQ APLRSSPNQVLPGQAGADPCPASEAPPAKAADPMAKPCPLPPLELGLPRDEVLQKQLPSF SQ VLPVPQKRNVTVDCFTPVTSLPQILVTQDLPNMPICQTNQSLVPVSEEQNSMPKSQNYLQ SQ NASPTPEKELACKTVLPEVGQSVPVSESSPTVQKVSVGRLSPQQESSASSKRMLSPANSL SQ DIAMEKHQKRAKDENGAVCSTNIRALELPSSRANESHKQKKPVLVRQLCTTEPLEGAALE SQ QGACSASGRSSNKAANLTQVLPTDSLSSRPSTFAVTDHVNELQEFKNTKVSTSLTPTVGS SQ FPAPSESACVLPLKSIDNNQEKGSPGVRHEENKVIQGQRPPLVSGLSLVSSSDTQQPSFP SQ SLKTATSFTWCYLLRQKALPLAQNDQKTSAYTGWTVSSSNPNPLGLPTKVALSLLNSKQK SQ TGKSLYCQAITTHSKSDLVVYSSKWKNNLSKRALGNQKATVVEFSNKDDSEINSEQDKEN SQ SLIKSEPRRIKIFDGGYKSNEDYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVR SQ PYHCSYCNFSFKTKGNLTKHMKSKAHSKKCVDLGVSVGLIDEQDTEESDEKQRFGCERSG SQ YDLEESDGPDEDDNDNEEDDDDSQAESGLSAAPSVTASPQHLPSRSGLQDPGSVEEELRV SQ SSCFSGVHTDPMDILPRALLTKMTVLSTVQSSPNRTDLPAKARQSTEKDEHEQAPPADTP SQ RSPGHQLSVHSSESDVLRSPAAGNPAAGSPGAAVQDSSVGLPPAVAQLNPQPAARISSSV SQ SPHPDSQDQKQQIILQPPPGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVTAGLT SQ YSTFVPIQAGPMQLTIPAVSVIHRTVGTSGDTITEASGSPNRPTGVAELSSVVPCIPIGQ SQ IHVPGLQNLSPPALQSLTSLGMETVNLVGLANATVGPQGHPPGLALNAVGLQVLANAPAQ SQ SSPAPPAHIQGLQILNIALPTLIPSVGPVAVGTTGTPETTAPNSKAMELQMPAGQGHSAE SQ PPQGSPEGPQETPQTVSGPSADHARPEDSTKMDTKKGPSAGHVLPGRSPAQAQPAPTPEA SQ LQKVATSAPPSLPTDRAAPRPPVPHRQPIVHFSDVSSDDDEDRLVIAT XX SC PIR #I49477 XX FT 409 429 zinc finger 1 FT 437 449 zinc finger 2 FT 955 980 zinc finger 3 FT 2076 2096 zinc finger 4 FT 2104 2126 zinc finger 5 FT 489 499 acidic region (7/11) FT 2162 2182 acidic region (15/21) XX SF 2 zinc finger motifs SF 72% identity with human PRDII-BF1 [2]; SF a testis-specific transcript exhibits smaller size SF (7.7 instead of 9.5 kb) [2]; XX CP newborn lens, brain, intestine, kidney, liver, lung, CP ovary, skeletal muscle, spleen, testis, thymus [1], [2]; XX FF activator [2]; XX BS R02115; AACRYBP1$CONS; Quality: 4 BS R01628; MOUSE$AACR_04; Quality: 6; mouse, Mus musculus XX DR EMBL: X68946; MMACRYBP1(r). DR EMBL: L36825; MMALCR01(g). DR EMBL: L36826; MMALCR02(g). DR EMBL: L36827; MMALCR03(g). DR EMBL: L36828; MMALCR04(g). DR EMBL: L36829; MMALCR05(g). DR PIR: I49477; I49477. XX RN [1] RA Nakamura T., Donovan D. M., Hamada K., Sax C. M., RA Norman B., Flanagan J. R., Ozato K., Westphal H., Piatigorsky J. RT Regulation of the mouse alphaA-crystallin gene: isolation RT of a cDNA encoding a protein that binds to a cis sequence RT motif shared with the major histocompability complex RT class I gene and other genes RL Mol. Cell. Biol. 10:3700-3708 (1990). RN [2] RA Brady J. P., Kantorow M., Sax C. M., Donovan D. M., Piatigorsky J. RT Murine transcription factor alphaA-crystallin binding protein I RL J. Biol. Chem. 270:1221-12229 (1995). RN [3] RA Sax C. M., Klement J. F., Piatigorsky J. RT Species-specific lens activation of the thymidine RT kinase promoter by a single copy of the mouse alpha RT A-CRYBP1 site and loss of tissue specificity by multimerization RL Mol. Cell. Biol. 10:6813-6816 (1990). XX // AC T00008 XX ID T00008 XX DT 15.10.92 (created); ewi. DT 31.05.96 (updated); ewi. XX FA Adf-1 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0022; trp; 3.5.1.2.4. XX SZ 253 AA; 29.2 kDa (cDNA), 34 kDa (SDS) XX SQ MDKLDANLEQQFDLNLIEAVKLNPVIYDRSHYNYKHFVRKAQTWKQIAETLGVPEQKCTK SQ RWKSLRDKFAREMKLCQESRWRYFKQMQFLVDSIRQYRESLLGKCANGSQSANQVADPSQ SQ QQQAQQQTVVDIFAQPFNGSATTSAQALTHPHEITVTSDAQLATAVGKDQKPYFYEPPLK SQ RERSEEEHSDNMLNTIKIFQNNVSQAVSAEDQSFGMVVTDMLNTLGVRQKAEAKVHIIKY SQ LTDMQLLAQHNKY XX SC SwissProt #P05552 XX FT 110 135 glutamine-rich region (10/26) FT 44 81 tryptophan cluster (W-X17-W-X18-W) XX CP ubiquitous [4]; XX FF activator of alcohol dehydrogenase gene [4]; FF no protein found in early embryos [4]; XX BS R04245; ADF1$CONS_01; Quality: 6 BS R00058; DROME$ADH_06; Quality: 6; fruit fly, Drosophila melanogaster BS R00059; DROME$ADH_07; Quality: 6; fruit fly, Drosophila melanogaster BS R00060; DROME$ADH_08; Quality: 6; fruit fly, Drosophila melanogaster BS R00066; DROME$ADH_14; Quality: 6; fruit fly, Drosophila melanogaster BS R00067; DROME$ADH_15; Quality: 6; fruit fly, Drosophila melanogaster BS R00130; DROME$ANTP_02; Quality: 6; fruit fly, Drosophila melanogaster BS R00131; DROME$ANTP_03; Quality: 6; fruit fly, Drosophila melanogaster BS R00132; DROME$ANTP_04; Quality: 6; fruit fly, Drosophila melanogaster BS R00293; DROME$DDC_01; Quality: 6; fruit fly, Drosophila melanogaster BS R01966; DROOR$ADH_08; Quality: 6; fruit fly, Drosophila orena BS R01986; DROOR$ADH_18; Quality: 6; fruit fly, Drosophila orena XX DR EMBL: M37787; DMADF1A(r). DR SwissProt: P05552; ADF1_DROME. DR PIR: A38201; A38201. DR Flybase: FBgn0000054; Adf1. XX RN [1] RA Heberlein U., England B., Tjian R. RT Characterization of Drosophila transcription factors RT that activate the tandem promoters of the alcohol dehydrogenase gene RL Cell 41:965-977 (1985). RN [2] RA Heberlein U., Tjian R. RT Temporal pattern of alcohol dehydrogenase gene transcription RT reproduced by Drosophila stage-specific embryonic extracts RL Nature 331:410-415 (1988). RN [3] RA Ewel A., Jackson J. R., Benyajati C. RT Alternative DNA-protein interactions in variable-length RT internucleosomal regions associated with Drosophila RT Adh distal promoter expression RL Nucleic Acids Res. 18:1771-1781 (1990). RN [4] RA England B. P., Admon A., Tjian R. RT Cloning of Drosophila transcription factor Adf-1 reveals RT homology to Myb oncoproteins RL Proc. Natl. Acad. Sci. USA 89:683-687 (1992). XX // AC T00009 XX ID T00009 XX DT 15.10.92 (created); ewi. XX FA Adf-2a XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX BS R00055; DROME$ADH_03; Quality: 6; fruit fly, Drosophila melanogaster XX DR Flybase: FBgn0010008; Adf2. XX RN [1] RA Ewel A., Jackson J. R., Benyajati C. RT Alternative DNA-protein interactions in variable-length RT internucleosomal regions associated with Drosophila RT Adh distal promoter expression RL Nucleic Acids Res. 18:1771-1781 (1990). XX // AC T00010 XX ID T00010 XX DT 15.10.92 (created); ewi. XX FA Adf-2b XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX BS R00063; DROME$ADH_11; Quality: 6; fruit fly, Drosophila melanogaster XX DR Flybase: FBgn0010008; Adf2. XX RN [1] RA Ewel A., Jackson J. R., Benyajati C. RT Alternative DNA-protein interactions in variable-length RT internucleosomal regions associated with Drosophila RT Adh distal promoter expression RL Nucleic Acids Res. 18:1771-1781 (1990). XX // AC T00011 XX ID T00011 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA ADR1 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0001; CH; 2.3.3.0.2. XX SZ 1323 AA; 151 kDa XX SQ MANVEKPNDCSGFPVVDLNSCFSNGFNNEKQEIEMETDDSPILLMSSSASRENSNTFSVI SQ QRTPDGKIITTNNNMNSKINKQLDKLPENLRLNGRTPSGKLRSFVCEVCTRAFARQEHLK SQ RHYRSHTNEKPYPCGLCNRCFTRRDLLIRHAQKIHSGNLGETISHTKKVSRTITKARKNS SQ ASSVKFQTPTYGTPDNGNFLNRTTANTRRKASPEANVKRKYLKKLTRRASFSAQSASSYA SQ LPDQSSLEQHPKDRVKFSTPELVPLDLKNPELDSSFDLNMNLDLNLNLDSNFNIALNRSD SQ SSGSTMNLDYKLPESANNYTYSSGSPTRAYVGANTNSKNASFNDADLLSSSYWIKAYNDH SQ LFSVSESDETSPMNSELNDTKLIVPDFKSTIHHLKDSRSSSWTVAIDNNSNNNKVSDNQP SQ DFVDFQELLDNDTLGNDLLETTAVLKEFELLHDDSVSATATSNEIDLSHLNLSNSPISPH SQ KLIYKNKEGTNDDMLISFGLDHPSNREDDLDKLCNMTRDVQAIFSQYLKGEESKRSLEDF SQ LSTSNRKEKPDSGNYTFYGLDCLTLSKISRALPASTVNNNQPSHSIESKLFNEPMRNMCI SQ KVLRYYEKFSHDSSESVMDSNPNLLSKELLMPAVSELNEYLDLFKNNFLPHFPIIHPSLL SQ DLDLDSLQRYTNEDGYDDAENAQLFDRLSQGTDKEYDYEHYQILSISKIVCLPLFMATFG SQ SLHKFGYKSQTIELYEMSRRILHSFLETKRRCRSTTVNDSYQNIWLMQSLILSFMFALVA SQ DYLEKIDSSLMKRQLSALCSTIRSNCLPTISANSEKSINNNNEPLTFGSPLQYIIFESKI SQ RCTLMAYDFCQFLKCFFHIKFDLSIKEKDVETIYIPDNESKWASESIICNGHVVQKQNFY SQ DFRNFYYSFTYGHLHSIPEFLGSSMIYYEYDLRKGTKSHVFLDRIDTKRLERSLDTSSYG SQ NDNMAATNKNIAILIDDTIILKNNLMSMRFIKQIDRSFTEKVRKGQIAKIYDSFLNSVRL SQ NFLKNYSVEVLCEFLVALNFSIRNISSLYVEEESDCSQRMNSPELPRIHLNNQALSVFNL SQ QGYYYCFILIIKFLLDFEATPNFKLLRIFIELRSLANSILLPTLSRLYPQEFSGFPDVVF SQ TQQFINKDNGMLVPGLSANEHHNGASAAVKTKLAKKINVEGLAMFINEILVNSFNDTSFL SQ NMEDPIRNEFSFDNGHRAVTDLPRSAHFLSDTGLEGINFSGLNDSHQTVSTLNLLRYGEN SQ HSSKHKNGGKGQGFAEKYQLSLKYVTIAKLFFTNVKENYIHCHMLDKMASDFHTLENHLK SQ GNS XX SC SwissProt #P07248 XX FT 76 172 DNA-binding FT 99 155 zinc fingers FT 227 239 inhibition of activation FT 263 571 required for ADH2 activation FT 288 330 inhibition of activation FT 399 507 glycerol metabolism XX SF 2 zinc finger motifs SF P (cAMP-dep.) SF Zn2+-dependent folding: Ala-scanning of the zinc fingers: SF alpha-helix of the first finger important SF SF required for ADH2 activation and for glycerol metabolism XX FF activator, inactivated by phosphorylation while DNA-binding is retained; FF positive regulator of peroxisomal protein genes [7]; XX MX M00048; F$ADR1_01 XX BS R00074; Y$ADH2_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R00075; Y$ADH2_02; Quality: 1; yeast, Saccharomyces cerevisiae BS R00076; Y$ADH2_03; Quality: 6; yeast, Saccharomyces cerevisiae BS R02962; Y$CTA1_02; Quality: 1; yeast, Saccharomyces cerevisiae XX DR EMBL: U28414; SC28414(g). DR SwissProt: P07248; ADR1_YEAST. DR PIR: A24534; A24534. DR PDB: 1ard; YEAST TRANSCRIPTION FACTOR ADR1 (RESIDUES 102 - 130) (WILD TYPE). DR PDB: 1are; YEAST TRANSCRIPTION FACTOR ADR1 (RESIDUES 102 - 130) (ADR1B:H118A). DR PDB: 1arf; YEAST TRANSCRIPTION FACTOR ADR1 (RESIDUES 102 - 130) (ADR B:H118Y). DR PDB: 1paa; YEAST TRANSCRIPTION FACTOR ADR1 (RESIDUES 130 - 159) C-TERMINAL ZINC FINGER DOMAIN (P131A,P133A,C140A). XX RN [1] RA Eisen A., Taylor W. E., Blumberg H., Young E. T. RT The Yeast Regulatory Protein ADR1 Binds in a Zinc-Dependent RT Manner to the Upstream Activating Sequence of ADH2 RL Mol. Cell. Biol. 8:4552-4556 (1988). RN [2] RA Thukral S. K., Tavianni M. A., Blumberg H., Young E. T. RT Localization of a Minimal Binding Domain and Activation RT Regions in Yeast Regulatory Protein ADR1 RL Mol. Cell. Biol. 9:2360-2369 (1989). RN [3] RA Beier D. R., Sledziewski A., Young E. T. RT Deletion analysis identifies a region, upstream of RT the ADH2 gene of Saccharomyces cerevisiae, which is RT required for ADR1-mediated derepression RL Mol. Cell. Biol. 5:1743-1749 (1985). RN [4] RA Cook W. J., Chase D., Audino D. C., Denis C. L. RT Dissection of the ADR1 protein reveals multiple, functionally RT redundant activation domains enterspersed with inhibitory RT regions: evidence for a repressor binding to the ADR1c region RL Mol. Cell. Biol. 14:629-640 (1994). RN [5] RA Cheng C., Kacherovsky N., Dombek K. M., Camier S., RA Thukral S. K., Rhim E., Young E. T. RT Identification of potential target genes for Adr1p RT through characterization of essential nucleotides in UAS1 RL Mol. Cell. Biol. 14:3842-3852 (1994). RN [6] RA Hartshorne T. A., Blumberg H., Young E. T. RT Sequence homology of the yeast regulatory protein RT ADR1 with Xenopus transcription factor TFIIIA RL Nature 320:283-287 (1986). RN [7] RA Simon M., Adam G., Rapatz W., Spevak W., Ruis H. RT The Saccharomyces cerevisiae ADR1 gene is a positive RT regulator of transcription of genes encoding peroxisomal proteins RL Mol. Cell. Biol. 11:699-704 (1991). RN [8] RA Thukral S. K., Eisen A., Young E. T. RT Two monomers of yeast transcription factor ADR1 bind RT a palindromic sequence symmetrically to activate ADH2 expression RL Mol. Cell. Biol. 11:1566-1577 (1991). RN [9] RA Bemis L. T., Denis C. L. RT Identification of Functional Regions in the Yeast RT Transcriptional Activator ADR1 RL Mol. Cell. Biol. 8:2125-2131 (1988). RN [10] RA Taylor W. E., Young E. T. RT cAMP-dependent phosphorylation and inactivation of RT yeast transcription factor ADR1 does not affect DNA binding RL Proc. Natl. Acad. Sci. USA 87:4098-4102 (1990). RN [11] RA Parraga G., Horvath S., Hood L., Young E. T., Klevit R. E. RT Spectroscopic studies of wild-type and mutant zinc RT finger peptides: Determinants of domain folding and structure RL Proc. Natl. Acad. Sci. USA 87:137-141 (1990). RN [12] RA Parraga G., Horvath S. J., Eisen A., Taylor W. E., RA Hood L., Young E. T., Klevit R. E. RT Zinc-dependent structure of a single-finger domain of yeast ADR1 RL Science 241:1489-1492 (1988). RN [13] RA Cherry J. R., Johnson T. R., Dollard C., Shuster J. R., Denis C. L. RT Cyclic AMP-dependent protein kinase phosphorylates RT and inactivates the yeast transcriptional activator ADR1 RL Cell 56:409-419 (1989). RN [14] RA Thukral S. K., Morrison M. L., Young E. T. RT Alanine scanning site-directed mutagenesis of the RT zinc fingers of transcription factor ADR1: Residues RT that contact DNA and that transactivate RL Proc. Natl. Acad. Sci. USA 88:9188-9192 (1991). XX // AC T00012 XX ID T00012 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA AF-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01612; HS$APOB_01; Quality: 6; human, Homo sapiens XX RN [1] RA Metzger S., Leff T., Breslow J. L. RT Nuclear factors AF-1 and C/EBP bind to the human ApoB RT gene promoter and modulate its transcriptional activity in hepatic cells RL J. Biol. Chem. 265:9978-9983 (1990). RN [2] RA Leff T., Reue K., Melian A., Culver H., Breslow J. L. RT A Regulatory Element in the ApoCIII Promoter That RT Directs Hepatic Specific Transcription Binds to Proteins RT in Expressing and Nonexpressing Cell Types RL J. Biol. Chem. 264:16132-16137 (1989). XX // AC T00013 XX ID T00013 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA AF-1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO NF-BA1 XX CP (liver) XX BS R02657; HS$APOC3_01; Quality: 4; human, Homo sapiens BS R01690; RAT$PEPCK_15; Quality: 4; rat, Rattus norvegicus XX RN [1] RA Trus M., Benvenisty N., Cohen H., Reshef L. RT Developmentally Regulated Interaction of Liver Nuclear RT Factors with the Rat Phosphoenolpyruvate Carboxykinase Promoter RL Mol. Cell. Biol. 10:2418-2422 (1990). XX // AC T00014 XX ID T00014 XX DT 15.12.92 (created); ewi. XX FA AF-2 XX SY AF2; accessory factor 2; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (liver) XX FF cooperates with glucocorticoid receptor XX BS R02350; RAT$PEPCK_16; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Imai E., Stromstedt P.-E., Quinn P. G., Carlstedt-Duke RA J., Gustafsson J.-A., Granner D. K. RT Characterization of a complex glucocorticoid response RT unit in the phosphoenolpyruvate carboxykinase gene RL Mol. Cell. Biol. 10:4712-4719 (1990). XX // AC T00015 XX ID T00015 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA AFP1 XX SY AFP-1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO LF-B1 XX BS R01913; HBV$SA_02; Quality: 6; HBV, human hepatitis B virus BS R00080; HS$ALBU_04; Quality: 6; human, Homo sapiens BS R01625; RAT$A1I3_03; Quality: 6; rat, Rattus norvegicus BS R00424; RAT$AFEP_01; Quality: 6; rat, Rattus rattus BS R00430; RAT$AFEP_07; Quality: 6; rat, Rattus rattus XX RN [1] RA Sawadaishi K., Morinaga T., Tamaoki T. RT Interaction of a Hepatoma-Specific Nuclear Factor RT with Transcription-Regulatory Sequences of the Human RT alpha-Fetoprotein and Albumin Genes RL Mol. Cell. Biol. 8:5179-5187 (1988). RN [2] RA Abraham L. J., Bradshaw A. D., Shiels B. R., Northemann RA W., Hudson G., Fey G. H. RT Hepatic Transcription of the Acute-Phase alpha1-Inhibitor RT III Gene Is Controlled by a Novel Combination of cis-Acting RT Regulatory Elements RL Mol. Cell. Biol. 10:3483-3491 (1990). RN [3] RA Nakao K., Miyao Y., Ohe Y., Tamaoki T. RT Involvement of an AFP1-binding site in cell-specific RT transcription of the pre-S1 region of the human hepatitis RT B virus surface antigen gene RL Nucleic Acids Res. 17:9833 (1989). XX // AC T00016 XX ID T00016 XX DT 15.10.92 (created); ewi. DT 08.01.96 (updated); hiwi. XX FA AGIE-BP1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; 2.3.4.0.6. XX SZ >250 kDa XX SF (at least) 2 zinc finger motifs SF ac XX CP (liver) XX BS R02118; AGIEBP1$CONS; Quality: 2 BS R01747; RAT$ANTEN_03; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Ron D., Brasier A. R., Habener J. F. RT Angiotensinogen gene-inducible enhancer-binding protein RT 1, a member of a new family of large nuclear proteins RT that recognize nuclear factor kappaB-binding sites RT through a zinc finger motif RL Mol. Cell. Biol. 11:2887-2895 (1991). XX // AC T00017 XX ID T00017 XX DT 23.11.92 (created); ewi. DT 23.06.97 (updated); ewi. XX FA C/EBPbeta XX SY AGP/EBP; ANF-2; CRP2; H-APF-2; IL-6DBP; LAP; LAP1; NF-IL6; NF-M; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.3.0.2.1. XX SZ 296 AA; 31.5 kDa (cDNA) XX SQ MHRLLAWDAACLPPPPAAFRPMEVANFYYEPDCLAYGAKAARAAPRAPAAEPAIGEHERA SQ IDFSPYLEPLAPAADFAAPAPAHHDFLSDLFADDYGAKPSKKPADYGYVSLGRAGAKAAP SQ PACFPPPPPAALKAEPGFEPADCKRADDAPAMAAGFPFALRAYLGYQATPSGSSGSLSTS SQ SSSSPPGTPSPADAKAAPAACFAGPPAAPAKAKAKKTVDKLSDEYKMRRERNNIAVRKSR SQ DKAKMRNLETQHKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASAGHC XX SC SwissProt #P28033 XX FT 228 246 basic region FT 250 285 leucine zipper (TL5) FT 276 276 Ser-phosphorylation [8]; XX SF the leucine zipper motif may also interact with the SF Rel-domain of NF-kappaB1 (p50) thus causing synergistic SF effects of both factors [7], and with the DNA-binding SF domain of the estrogen receptor leading to an inhibition SF of C/EBPbeta activity [6]; XX CP ubiquitous XX FF activator, may enhace activation by glucocorticoids [2]; FF expressed very early during adipocyte differentiation, FF can be induced by adipogenic hormones; FF expression declines before onset of C/EBPalpha accumulation [9]; FF phosphorylated in pituitary cells by a calcium-calmodulin-dependent FF protein kinase at Ser-276 [8]; FF required for bactericidal and tumoricidal activities of macrophages [5]; XX IN T00017; C/EBPbeta; mouse, Mus musculus. IN T00104; C/EBPalpha; mouse, Mus musculus. IN T00105; C/EBPalpha; human, Homo sapiens. IN T00108; C/EBPalpha; rat, Rattus norvegicus. IN T00109; C/EBPdelta; rat, Rattus norvegicus. IN T00127; CHOP-10; mouse, Mus musculus. IN T00216; C/EBPgamma; mouse, Mus musculus. IN T00583; C/EBPdelta; human, Homo sapiens. IN T01114; C/EBPdelta; mouse, Mus musculus. IN T01303; CREB-2; human, Homo sapiens. XX MX M00109; V$CEBPB_01 MX M00117; V$CEBPB_02 XX BS R00207; AS$CEBP_01; Quality: 2 BS R02170; HAPF1$CONS; Quality: 6 BS R00238; HS$CRP_02; Quality: 6; human, Homo sapiens BS R02460; MOUSE$AGP_01; Quality: 6; mouse, Mus domesticus BS R02461; MOUSE$AGP_02; Quality: 6; mouse, Mus domesticus BS R02216; NFIL6$CONS; Quality: 6 BS R03414; RAT$AGP_02; Quality: 6; rat, Rattus norvegicus BS R01344; RSV$RSV_04; Quality: 6; RSV, rous sarcoma virus XX DR EMBL: M61007; MMAGP(r). DR EMBL: X62600; MMCEBP(g). DR SwissProt: P28033; CEBB_MOUSE. DR PIR: A36366; A36366. DR PIR: A37279; A37279. DR Compel: C00104 XX RN [1] RA Alam T., An M. R., Papaconstantinou J. RT Differential expression of three C/EBP isoforms in RT multiple tissues during the acute phase response RL J. Biol. Chem. 267:5021-5024 (1992). RN [2] RA Baumann H., Morella K. K., Campos S. P., Cao Z., Jahreis G. P. RT Role of CAAT-enhancer binding protein isoforms in RT the cytokine regulation of acute-phase plasma protein genes RL J. Biol. Chem. 267:19744-19751 (1992). RN [3] RA Ray A., Ray B. K. RT Serum amyloid A gene expression under acute-phase RT conditions involves participation of inducible C/EBP-beta RT and C/EBP-delta and their activation by phosphorylation RL Mol. Cell. Biol. 14:4324-4332 (1994). RN [4] RA Vallejo M., Ron D., Miller C. P., Habener J. F. RT C/ATF, a member of the activating transcription factor RT family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding RT proteins and directs their binding to cAMP response elements RL Proc. Natl. Acad. Sci. USA 90:4679-4683 (1993). RN [5] RA Tanaka T., Akira S., Yoshida K., Umemoto M., Yoneda RA Y., Shirafuji N., Fujiwara H., Suematsu S., Yoshida N., Kishimoto T. RT Targeted disruption of the NF-IL6 gene discloses its RT essential role in bacteria killing and tumor cytotoxicity by macrophages RL Cell 80:353-361 (1995). RN [6] RA Stein B., Yang M. X. RT Repression of the interleukin-6 promoter by estrogen RT rceptor is mediated by NF-kappaB and C/EBPbeta RL Mol. Cell. Biol. 15:4971-4979 (1995). RN [7] RA Stein B., Cogswell P. C., Baldwin A. S. RT Functional and physical associations between NF-kappaB RT and C/EBP family members: a Rel domain-bZIP interaction RL Mol. Cell. Biol. 13:3964-3974 (1993). RN [8] RA Wegner M., Cao Z., Rosenfeld M. G. RT Calcium-regulated phosphorylation within the leucine zipper of C/EBPbeta RL Science 256:370-373 (1992). RN [9] RA Cao Z., Umek R. M., McKnight S. L. RT Regulated expression of three C/EBP isoforms during RT adipose conversion of 3T3-L1 cells RL Genes Dev. 5:1538-1552 (1991). RN [10] RA Williams S. C., Cantwell C. A., Johnson P. F. RT A family of C/EBP-related proteins capable of forming RT covalently linked leucine zipper dimers in vitro RL Genes Dev. 5:1553-1567 (1991). RN [11] RA Chang C.-J., Chen T.-T., Lei H.-Y., Chen D.-S., Lee S.-C. RT Molecular cloning of a transcription factor, AGP/EBP, RT that belongs to members of the C/EBP family RL Mol. Cell. Biol. 10:6642-6653 (1990). RN [12] RA Chang C.-J., Chen T.-T., Lei H.-Y., Chen D.-Sh., Lee Sh.-Ch. RT Molecular cloning of a transcription factor, AGP/EBP, RT that belongs to members of the C/EBP family RL Mol. Cell. Biol. 10:6642-6653 (1990). XX // AC T00018 XX ID T00018 XX DT 25.01.93 (created); hse. DT 15.05.97 (updated); ewi. XX FA AhR XX SY Ah receptor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; 1.2.6.0.1. XX SZ 805 AA (prepro), 796 AA (mature); 89.4 kDa (cDNA), SZ 95 kDa (SDS) [3]; 277 kDa (sedim.) [2], [4]; XX SQ MSSGANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVI SQ NKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRNGGQDQCRAQIRDWQDLQEGEFLLQAL SQ NGFVLVVTADAFLFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRHVHWALNPDS SQ AQGVDEAHGPPQAAVYYTPDQLPPENASFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYL SQ HGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQL SQ ILGYTEVELCTRGSGYQFIHAADILHCAESHIRMIKTGESGMTVFRLLAKHSRWRWVQSN SQ ARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSTSLPFMFATGEAVLYEISSPFSPIMDP SQ LPIRTKSNTSRKDWAPQSTPSKDSFHPSSLMSALIQQDESIYLCPPSSPALLDSHFLMGS SQ VSKCGSWQDSFAAAGSEAALKHEQIGHAQDVNLALSGGPSELFPDNKNNDLYSIMRNLGI SQ DFEDIRSMQNEEFFRTDSTAAGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVTQ SQ HLSCMLQERLQLEQQQQLQQPPPQALEPQQQLCQMVCPQQDLGPKHTQINGTFASWNPTP SQ PVSFNCPQQELKHYQLFSSLQGTAQEFPYKPEVDSVPYTQNFAPCNQPLLPEHSKSVQLD SQ FPGRDFEPSLHPTTSNLDFVSCLQVPENQSHGINSQSAMVSPQAYYAGAMSMYQCQPGPQ SQ RTPVDQTQYSSEIPGSQAFLSKVQS XX SC SwissProt #P30561 XX FT 805 805 prepro peptide FT 31 38 basic region FT 39 80 helix-loop-helix domain FT 116 374 PAS domain FT 130 182 PAS domain repeat 1 (A) FT 288 339 PAS domain repeat 2 (B) FT 232 334 ligand-binding domain [11]; FT 340 422 hsp90-binding domain [13]; FT 593 805 trans-activating domain [13]; FT 594 640 glutamine-rich region (20/47) FT 83 341 essential for dioxin-induced DNA-binding [10]; XX SF 95 kDa: ligand-binding subunit SF Stokes radius: 7.1 nm [2], [4]; SF dissociation into subunits upon prolonged treatment SF with 0.4 M KCl sedimenting with 4.9-5.6 S [2]; SF pI(calc.) = 5.98 [11], pI(exp.) = 5.2-5.7 [12]; SF in heterodimeric complexes with Arnt, AhR preferably SF recognizes the half-site sequence TYGC [5]; SF interacts with hsp90 [3]; SF closely adjacent or overlapping domains for hsp90- SF and ligand-binding [8], [13]; SF other reports show interaction of hsp90 with the DNA-binding domain [10]; SF hsp90-interaction provides conformation suitable for SF ligand- and DNA-binding [8], [13], [10]; SF hsp90 represses, ligand-binding derepresses trans-activation domain [13]; SF possibly, another component associates with AhR to a 165-kDa complex [14]; SF transient activation of AhR depends on ligand-binding, SF on a phosphorylation step [6], [7], [1], [9], and SF on interaction with Arnt that promotes release of SF ligand-bound AhR from hsp90 [15]; SF Ahr heterodimerizes with Arnt through its PAS domain SF (homology domain with Drosophila Per and Sim) [16]; XX FF activator, binds to xenobiotic response element [7], [6], [17]; XX IN T00992; Hsp90; human, Homo sapiens. IN T01346; Arnt; human, Homo sapiens. IN T01797; Arnt; mouse, Mus musculus. XX MX M00139; V$AHR_01 MX M00235; V$AHRARNT_01 MX M00237; V$AHRARNT_02 XX BS R02117; AHR$CONS_01; Quality: 2 BS R02656; AHR$CONS_02; Quality: 6 BS R02649; MOUSE$CYTOP_01; Quality: 6; mouse, Mus musculus BS R02650; MOUSE$CYTOP_02; Quality: 6; mouse, Mus musculus BS R02651; MOUSE$CYTOP_03; Quality: 4; mouse, Mus musculus BS R02652; MOUSE$CYTOP_04; Quality: 6; mouse, Mus musculus BS R02653; MOUSE$CYTOP_05; Quality: 6; mouse, Mus musculus BS R02654; MOUSE$CYTOP_06; Quality: 6; mouse, Mus musculus BS R02339; MOUSE$GST_01; Quality: 5; mouse, Mus musculus BS R00270; RAT$CYTOP_04; Quality: 2; rat, Rattus norvegicus BS R00272; RAT$CYTOP_05; Quality: 6; rat, Rattus norvegicus XX DR EMBL: M94623; MMB1AHR(r). DR SwissProt: P30561; AHR_MOUSE. DR PIR: A46266; A46266. DR PIR: JQ1485; JQ1485. XX RN [1] RA Pongratz I., Stroemstedt P.-E., Mason G. G. F., Poellinger L. RT Inhibition of the specific DNA binding activity of RT the dioxin receptor by phosphatase treatment RL J. Biol. Chem. 266:16813-16817 (1991). RN [2] RA Denison M. S., Vella L. M., Okeys A. B. RT Structure and function of the Ah receptor for 2,3,7,8- RT tetrachlorodibenzo-p-dioxin RL J. Biol. Chem. 261:3987-3995 (1986). RN [3] RA Perdew G. H. RT Association of the Ah receptor with the 90-kDa heat shock protein RL J. Biol. Chem. 263:13802-13806 (1988). RN [4] RA Cuthill S., Poellinger L., Gustafsson J.-A. RT The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin RT in the mouse hepatoma cell line Hepa 1c1c7 RL J. Biol. Chem. 262:3477-3481 (1987). RN [5] RA Swanson H. I., Chan W. K., Bradfield C. A. RT DNA binding specificities and pairing rules of the RT Ah receptor, ARNT, and SIM proteins RL J. Biol. Chem. 270:26292-26302 (1995). RN [6] RA Fujisawa-Sehara A., Yamane M., Fuji-Kuriyama Y. RT A DNA-binding factor specific for xenobiotic responsive RT elements of P-450c gene exists as a cryptic form in RT cytoplasm: Its possible translocation to nucleus RL Proc. Natl. Acad. Sci. USA 85:5859-5863 (1988). RN [7] RA Denison M. S., Fisher J. M., Whitlock jr. J. P. RT Inducible, receptor-dependent protein-DNA interactions RT at a dioxin-responsive transcriptional activator RL Proc. Natl. Acad. Sci. USA 85:2528-2532 (1988). RN [8] RA Whitelaw M. L., Goettlicher M., Gustafsson J. A., Poelinger L. RT Definition of a novel ligand binding domain of a nuclear RT bHLH receptor: co-localization of ligand and hsp90 RT binding activities within the regulable inactivation RT domain of the dioxin receptor RL EMBO J. 12:4169-4179 (1993). RN [9] RA Reick M., Robertson R. W., Pasco D. S., Fagan J. B. RT Down-regulation of nuclear aryl hydrocarbon receptor RT DNA-binding and transactivation functions: requirement RT for a labile or inducible factor RL Mol. Cell. Biol. 14:5653-5660 (1994). RN [10] RA Antonsson C., Whitelaw M. L., McGuire J., Gustafsson J. -A., Poellinger L. RT Distinct roles of the molecular chaperone hsp90 in RT modulating dioxin receptor function via the basic RT helix-loop-helix and PAS domains RL Mol. Cell. Biol. 15:756-765 (1995). RN [11] RA Burbach K. M., Poland A., Bradfield C. A. RT Cloning of the Ah-receptor cDNA reveals a distinctive-ligand-activated RT transcription factor RL Proc. Natl. Acad. Sci. USA 89:8185-8189 (1992). RN [12] RA Perdew G. H., Hollenback C. E. RT Analysis of photoaffinity-labeled aryl hydrocarbon RT receptor heterogenity by two dimensional gel electrophoresis RL Biochemistry 29:6210-6214 (1990). RN [13] RA Whitelaw M. L., Gustafsson J. A., Poellinger L. RT Identification of transactivation and repression functions RT of the dioxin receptor and its basic helix-lop-helix/PAS RT partner Arnt: inductive versus constitutive modes of regulation RL Mol. Cell. Biol. 14:8343-8355 (1994). RN [14] RA de Morais S. M. F., Giannone J. V., Okey A. B. RT Photoaffinity labeling of Ah receptor with 3-[3H]methylcolanthrene RT and formation of a 165-kDa complex between the ligand-binding RT subunit and a novel cytosolic protein RL J. Biol. Chem. 269:12129-12136 (1994). RN [15] RA McGuire J., Whitelaw M., Pongratz I., Gustafsson J. A., Poellinger L. RT A cellular factor stimulates ligand-dependent release RT of hsp90 from the basic helix-loop-helix dioxin receptor RL Mol. Cell. Biol. 14:2438-2446 (1994). RN [16] RA Lindebro M. C., Poellinger L., Whitelaw M. L. RT Protein-protein interaction via PAS domains: role RT of the PAS domain in positive and negative regulation RT of the bHLH/PAS dioxin receptor-Arnt transcription factor complex RL EMBO J. 14:3528-3539 (1995). RN [17] RA Denison M. S., Fisher J. M., Whitlock J. P. RT Protein-DNA Interactions at Recognition Sites for RT the Dioxin-Ah Receptor Complex RL J. Biol. Chem. 264:16478-16482 (1989). RN [18] RA Paulson K. E., Darnell J. E., Rushmore T., Pickett C. B. RT Analysis of the upstream elements of the xenobiotic RT compound-inducible and positionally regulated glutathione RT S-transferase Ya gene RL Mol. Cell. Biol. 10:1841-1852 (1990). XX // AC T00019 XX ID T00019 XX DT 25.01.93 (created); hse. DT 23.06.97 (updated); ewi. XX FA AhR XX SY Ah receptor; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; 1.2.6.0.1. XX SZ 853 AA; 96.2 kDa (cDNA), 95 kDa (SDS) [1], [3], 257 SZ (sedim.) [1]; 121 (sedim., ligand-binding subunit) [1]; XX SQ MSSGANITYASRKRRKPVQKTVKPVPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVI SQ NKLDKLSVLRLSVTYLRAKSFFDVALKSTPADRSRGQDQCRAQVRDWQDLQEGEFLLQAL SQ NGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQ SQ CTDSAQGVDETHGLPQPAVYYTPDQLPPENTAFMERCFRCRLRCLLDNSSGFLAMNFQGR SQ LKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDA SQ KGQLILGYTEVELCNKGSGYQFIHAADMLHCAESHIRMIKTGESGMTVFRLLAKHSRWRW SQ VQSNARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSMTLPFMFATGEAVLYEISSPFSP SQ IMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPNSLMSALIQQDESIYLCPPSSPAPLDSHF SQ LMDSMSECGSWQGSFAVASNEALLKHEEIRHTQDVNLTLSGGPSELFPDNKNNDLYSIMR SQ NLGIDFEDIRSMQNEEFFRTDSSGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPV SQ SQHLSCMLQERLQLEQQQQLQQQHPTQTLEPQRQLCQVEVPQHELGQKTKHMQVNGMFVS SQ WNPAPPVSFSCPQQERKHICLLSGLQGTAQEFPYKSEVDSMPYTQNFAPCNQSLLPEHSK SQ GTQLDFPGRDFERSLHPNVSNLEEFVSCLQVPENQRHGINSQSAMVSPQGYYAGAMSMYQ SQ CQAGPQDTPVDQMQYSPEIPGSQAFLSKFQSPSILNEAYSADLSSIGHLQTAAHLPRLAE SQ AQPLPDITPSGFL XX SC conceptually translated from EMBL/GenBank/DDBJ #U04860 XX FT 31 38 basic region FT 39 80 helix-loop-helix domain FT 116 378 PAS domain FT 596 653 glutamine-rich region (20/58) XX SF 95 kDa: ligand-binding subunit SF Stokes radius: 7.0 nm SF dissociation into subunits upon treatment with 0.4 SF M KCl sedimenting with 4.9-5.6 S [1]; SF faster dissociation than murine complex [1]; SF interacts with hsp90 [2], [4]; XX CP highest levels in liver, lower in thymus, kidney, lung [7]; XX FF activator, binds to xenobiotic response element [6]; FF quickly up-regulated biaryl hydrocarbons within 30 FF min, down-regulated requiring an additional, labile FF factor over the subsequent 2 h [5]; XX IN T00992; Hsp90; human, Homo sapiens. XX MX M00139; V$AHR_01 MX M00235; V$AHRARNT_01 MX M00237; V$AHRARNT_02 XX BS R02117; AHR$CONS_01; Quality: 6 BS R02720; AHR$CONS_03; Quality: 4 BS R02651; MOUSE$CYTOP_03; Quality: 4; mouse, Mus musculus BS R00270; RAT$CYTOP_04; Quality: 4; rat, Rattus norvegicus XX DR EMBL: U04860; RN04860(r). DR EMBL: U09000; RN09000(r). XX RN [1] RA Denison M. S., Vella L. M., Okeys A. B. RT Structure and function of the Ah receptor for 2,3,7,8- RT tetrachlorodibenzo-p-dioxin RL J. Biol. Chem. 261:3987-3995 (1986). RN [2] RA Perdew G. H. RT Association of the Ah receptor with the 90-kDa heat shock protein RL J. Biol. Chem. 263:13802-13806 (1988). RN [3] RA Cuthill S., Poellinger L., Gustafsson J.-A. RT The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin RT in the mouse hepatoma cell line Hepa 1c1c7 RL J. Biol. Chem. 262:3477-3481 (1987). RN [4] RA Denis M., Cuthill S., Wikstroem A.-C., Poellinger L., Gustafsson J.-A. RT Association of the dioxin receptor with the Mr 90.000 RT heat shock protein: a structural kinship with the glucocorticoid receptor RL Biochem. Biophys. Res. Commun. 155:801-807 (1988). RN [5] RA Haas N. B., Cantwell C. A., Johnson P. F., Burch J. B. E. RT DNA-binding specificity of the PAR basic leucine zipper RT protein VBP partially overlaps those of the C/EBP RT and CREB/ATF families and is influenced by domains RT that flank the core basic region RL Mol. Cell. Biol. 15:1923-1932 (1995). RN [6] RA Hapgood J., Cuthill S., Denis M., Poellinger L., Gustafsson J.-A. RT Specific protein-DNA interactions at a xenobiotic-responsive RT element: Copurification of dioxin receptor and DNA-binding affinity RL Proc. Natl. Acad. Sci. USA 86:60-64 (1989). RN [7] RA Carver L. A., Hogenesch J. B., Bradfield C. A. RT Tissue specific expression of the rat Ah-receptor and ARNT mRNAs RL Nucleic Acids Res. 22:3038-3044 (1994). RN [8] RA Reick M., Robertson R. W., Pasco D. S., Fagan J. B. RT Down-regulation of nuclear aryl hydrocarbon receptor RT DNA-binding and transactivation functions: requirement RT for a labile or inducible factor RL Mol. Cell. Biol. 14:5653-5660 (1994). RN [9] RA Fujisawa-Sehara A., Sogawa K., Yamane M., Fuji-Kurijama Y. RT Characterization of xenobiotic response elements upstream RT from the drug-metabolizing cytochrome P450c gene: RT a similarity to glucocorticoid regulatoty elements RL Nucleic Acids Res. 15:4179-4191 (1987). XX // AC T00020 XX ID T00020 XX DT 12.03.93 (created); ewi. XX FA AIC2 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (liver) XX BS R02959; HS$APOA1_02; Quality: 6; human, Homo sapiens XX RN [1] RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., RA Monaci P., Cladaras C., Zannis V. I. RT Promoter elements and factors involved in hepatic RT transcription of the human ApoA-I gene positive and RT negative regulators bind to overlapping sites RL J. Biol. Chem. 266:5790-5797 (1991). XX // AC T00021 XX ID T00021 XX DT 12.03.93 (created); ewi. XX FA AIC3 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (liver) XX BS R02959; HS$APOA1_02; Quality: 6; human, Homo sapiens XX RN [1] RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., RA Monaci P., Cladaras C., Zannis V. I. RT Promoter elements and factors involved in hepatic RT transcription of the human ApoA-I gene positive and RT negative regulators bind to overlapping sites RL J. Biol. Chem. 266:5790-5797 (1991). XX // AC T00022 XX ID T00022 XX DT 12.03.93 (created); ewi. XX FA AIC4 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (liver) XX BS R02959; HS$APOA1_02; Quality: 6; human, Homo sapiens XX RN [1] RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., RA Monaci P., Cladaras C., Zannis V. I. RT Promoter elements and factors involved in hepatic RT transcription of the human ApoA-I gene positive and RT negative regulators bind to overlapping sites RL J. Biol. Chem. 266:5790-5797 (1991). XX // AC T00023 XX ID T00023 XX DT 12.03.93 (created); ewi. XX FA AIC5 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (liver) XX BS R02959; HS$APOA1_02; Quality: 6; human, Homo sapiens XX RN [1] RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., RA Monaci P., Cladaras C., Zannis V. I. RT Promoter elements and factors involved in hepatic RT transcription of the human ApoA-I gene positive and RT negative regulators bind to overlapping sites RL J. Biol. Chem. 266:5790-5797 (1991). XX // AC T00024 XX ID T00024 XX DT 12.03.93 (created); ewi. XX FA AID2 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (liver) XX BS R00135; HS$APOA1_01; Quality: 6; human, Homo sapiens XX RN [1] RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., RA Monaci P., Cladaras C., Zannis V. I. RT Promoter elements and factors involved in hepatic RT transcription of the human ApoA-I gene positive and RT negative regulators bind to overlapping sites RL J. Biol. Chem. 266:5790-5797 (1991). XX // AC T00025 XX ID T00025 XX DT 13.11.92 (created); ewi. DT 12.07.94 (updated); hse; ewi. XX FA ANF XX SY albumin negative factor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP ubiquitous XX FF negative regulator XX BS R02119; ANF$CONS; Quality: 4 BS R02333; MOUSE$ALBU_12; Quality: 6; mouse, Mus musculus BS R02334; MOUSE$ALBU_13; Quality: 6; mouse, Mus musculus XX RN [1] RA Herbst R. S., Boczo E. M., Darnell J. E., Babiss L. E. RT The louse albumin enhancer contains a negative regulatory RT element that interacts with a novel DNA-binding protein RL Mol. Cell. Biol. 10:3896-3905 (1990). RN [2] RA Herbst R. S., Boczko E. M., Darnell Jr. J. E., Babiss L. E. RT The mouse albumin enhancer contains a negative regulatory RT element that interacts with a novel DNA-binding protein RL Mol. Cell. Biol. 10:3896-3905 (1990). XX // AC T00026 XX ID T00026 XX DT 15.10.92 (created); ewi. DT 06.12.96 (updated); ewi. XX FA Antp XX SY Antennapedia; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0006; homeo; 3.1.1.2.2. XX SZ 378 AA; 42.8 kDa (gene) XX SQ MTMSTNNCESMTSYFTNSYMGADMHHGHYPGNGVTDLDAQQMHHYSQNANHQGNMPYPRF SQ PPYDRMPYYNGQGMDQQQQHQVYSRPDSPSSQVGGVMPQAQTNGQLGVPQQQQQQQQQPS SQ QNQQQQQAQQAPQQLQQQLPQVTQQVTHPQQQQQQPVVYASCKLQAAVGGLGMVPEGGSP SQ PLVDQMSGHHMNAQMTLPHHMGHPQAQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVPPV SQ GAPPQGMMHQGQGPPQMHQGHPGQHTPPSQNPNSQSSGMPSPLYPWMRSQFGKCQERKRG SQ RQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTKG SQ EPGSGGEGDEITPPNSPQ XX SC SwissProt #P02833 XX FT 72 81 glutamine-rich region (6/10) FT 110 155 glutamine-rich region (31/46) FT 283 288 Antp-type hexapeptide FT 292 295 missing in splice variant FT 297 356 homeo domain XX SF 1H-,15N-NMR free in solution [22], [12] and as complex SF with a 14 bp DNA [23]; SF homeo domain similar to helix-turn-helix motif of SF the DNA-binding domain of prokaryotic repressors [22]; SF 3 well-defined alpha-helices and a fourth, flexible one [22]; SF the isolated homeo domain binds to DNA as a monomer [21]; SF helix 3 is the recognition helix [22], but helix 2 SF makes additoinal major groove contacts [23]; SF the loop preceding the helix-turn-helix motif also SF contacts the DNA, and an ariginine close to the amino SF terminus of the homeo domain performs a minor groove contact [23]; SF this part defines the functional difference between SF Antp and Scr or Ubx [17] and contributes to the overall SF binding affinity [15]; SF it provides a flexible link between the homeo domain SF and the rest of the molecule, it is subject of alternative SF splicing [12], [4]; SF N-terminal arm plus C-terminal tail are required to SF define embryonal segment identity [17]; SF DNA-binding affinity is 1.6 nM (from equilibrium studies) SF or 0.18 nM (from kinetic studies) [21]; XX FF activator of Ubx; FF homeotic selector gene; FF transcription is driven by two promoters, P1 and P2, FF approx. 65 kb apart [4], [5], [9] and exerting differential FF stage- and tissue-specificity [11]; FF subject to several cross-regulation with other homeo FF domain factors [14] and, potentially, of a positive auoregulatory loop [3]; XX BS R00129; DROME$ANTP_01; Quality: 6; fruit fly, Drosophila melanogaster BS R02504; DROME$EN_09; Quality: 6; fruit fly, Drosophila melanogaster BS R02505; DROME$EN_10; Quality: 6; fruit fly, Drosophila melanogaster BS R02506; DROME$FTZ_31; Quality: 6; fruit fly, Drosophila melanogaster BS R02622; DROME$UBX_20; Quality: 6; fruit fly, Drosophila melanogaster BS R01678; MOUSE$NCAM_05; Quality: 2; mouse, Mus musculus XX DR EMBL: K01948; DMANTC2(g). DR EMBL: M12009; DMANTPA(g). DR EMBL: X03790; DMANTPE4(g). DR EMBL: X03791; DMANTPE8(g). DR EMBL: M14496; DMANTPG5(g). DR EMBL: M20704; DMANTPRA(r). DR EMBL: M20705; DMANTPRB(r). DR SwissProt: P02833; HMAN_DROME. DR PIR: A03318; A03318. DR PIR: A23450; A23450. DR PIR: A25399; A25399. DR PIR: A25400; A25400. DR PIR: C24780; C24780. DR Flybase: FBgn0000095; Antp. DR PDB: 1ahd; ANTENNAPEDIA PROTEIN (HOMEODOMAIN) MUTANT (C39S) COMPLEX WITH DNA (NMR, 16 STRUCTURES) D. MELANOGASTER. DR PDB: 1hom; ANTENNAPEDIA PROTEIN (HOMEODOMAIN) (NMR, 19 STRUCTURES) D. MELANOGASTER. DR PDB: 1san; ANTENNAPEDIA PROTEIN (HOMEODOMAIN) MUTANT (C39S,DEL 1-6) D. MELANOGASTER. DR PDB: 2hoa; ANTENNAPEDIA PROTEIN (HOMEODOMAIN) MUTANT (C39S) D. MELANOGASTER. XX RN [1] RA Mihara H., Kaiser E. T. RT A chemically synthesized Antennapedia homeo domain RT binds to a specific DNA sequence RL Science 242:925-927 (1988). RN [2] RA Ekker S. C., Jackson D. G., von Kessler D. P., Sun RA B. I., Young K. E., Beachy P. A. RT The degree of variation in DNA sequence recognition RT among four Drosophila homeotic proteins RL EMBO J. 13:3551-3560 (1994). RN [3] RA Appel B., Sakonju S. RT Cell-type-specific mechanisms of transcriptional repression RT by the homeotic gene products UBX and ABD-A in Drosophila embryos RL EMBO J. 12:1099-1109 (1993). RN [4] RA Schneuwly S., Kuroiwa A., Baumgartner P., Gehring W. J. RT Structural organization and sequence of the homeotic RT gene Antennapedia of Drosophila melanogaster RL EMBO J. 5:733-739 (1986). RN [5] RA McGinnis W., Garber R. L., Wirz J., Kuroiwa A., Gehring W. J. RT A homologous protein-coding sequence in Drosophila RT homeotic genes and its conservation in other metazoans RL Cell 37:403-408 (1984). RN [6] RA Scott M. P., Weiner A. RT Structural relationships among genes that control RT develop-ment: Sequence homology between the Antennapedia, RT Ultrabithorax, and fushi tarazu loci of Droso-phila RL Proc. Natl. Acad. Sci. USA 81:4115-4119 (1984). RN [7] RA Stroeher V. L., Jorgensen E. M., Garber R. L. RT Multiple transcripts from the anten-napedia gene of Drosophila melanogaster RL Mol. Cell. Biol. 6:4667-4675 (1986). RN [8] RA Regulski M., Harding K., Kostriken R., Karch F., Levine M., McGinnis W. J. RT Homeo box genes of the antennapedia and bithorax complexes of Drosophila RL Cell 43:71-80 (1985). RN [9] RA Laughon A. S., Boulet A. M., Bermingham J. R., Laymon R. A., Scott M. P. RT Structure of transcripts from the homeotic Antennapedia RT gene of Drosophila melanogaster: Two promoters control RT the major protein-coding region RL Mol. Cell. Biol. 6:4676-4689 (1986). RN [10] RA McGinnis W., Levine M. S., Hafen E., Kuroiwa A., Gehring W. J. RT A conserved DNA sequence in homeotic genes of the RT Drosophila Antennapedia and bithorax complexes RL Nature 308:428-433 (1984). RN [11] RA Bermingham J. R. jr., Martinez-Arias A., Petitt M. G., Scott M. P. RT Different patterns of transcription from the two Antennapedia RT promoters during Drosophila embryogenesis RL Development 109:553-566 (1990). RN [12] RA Qian Y.-Q., Otting G., Furukubo-Tokinaga K., Affolter RA M., Gehring W. J., Whthrich K. RT NMR structure determination reveals that the homeodomain RT is connected through a flexible linker to the main RT body in the Drosophila Antennapedia protein RL Proc. Natl. Acad. Sci. USA 89:10738-10742 (1992). RN [13] RA Furukubo-Tokinaga K., Flister S., Gehring W. J. RT Functional specificity of the Antennapedia homeodomain RL Proc. Natl. Acad. Sci. USA 90:6390-6364 (1993). RN [14] RA Saffman E. E., Krasnow M. A. RT A differential response element for the homeotics RT at the Antennapedia P1 promoter of Drosophila RL Proc. Natl. Acad. Sci. USA 91:7420-7424 (1994). RN [15] RA Qian Y. Q., Resendez-Perez D., Gehring W. J., Wuethrich K. RT The des(1-6)Antennapedia homeodomain: Comparison of RT the NMR solution structure and the DNA-binding affinity RT with the intact Antennapedia homeodomain RL Proc. Natl. Acad. Sci. USA 91:4091-4095 (1994). RN [16] RA Billeter M., Qian Y.-Q., Otting G., Mueller M., Gehring W. J. RT Determination of the three-dimensional structure of RT the Antennapedia homeodomain from Drosophila in solution RT by 1H nuclear magnetic resonance spectroscopy. RL J. Mol. Biol. 214:183-197 (1990). RN [17] RA Chan S.- K., Mann R. S. RT The segment identity functions of Ultrabithorax are RT contained within its homeodomain and carboxy-terminal seuqences RL Genes Dev. 7:796-811 (1993). RN [18] RA Qian Y.-Q., Otting G., Billeter M., Mueller M., Gehring W. J., Wuethrich K. RT Nuclear magnetic resonance spectroscopy of a DNA complex RT with the uniformly 13C-labeled Antennapedia homeodomain RT and structure determination of the DNA-bound homeodomain. RL J. Mol. Biol. 234:1070-1083 (1993). RN [19] RA Billeter M., Qian Y.-Q., Otting G., Mulller M., Gehring W. J., Wutethrich K. RT Determination of the nuclear magnetic resonance solution RT structure of an Antennapedia homeodomain-DNA complex RL J. Mol. Biol. 234:1084-1093 (1993). RN [20] RA Winslow G. M., Hayashi S., Krasnow M., Hogness D. S., Scott M. P. RT Functional Activation by the Antennapedia and fushi RT tarazu Proteins in Cultured Drosophila Cells RL Cell 57:1017-1030 (1989). RN [21] RA Affolter M., Percival-Smith A., Mueller M., Leupin W., Gehring W. J. RT DNA binding properties of the purified Antennapedia homeodomain RL Proc. Natl. Acad. Sci. USA 87:4093-4097 (1990). RN [22] RA Qian Y. G., Billeter M., Otting G., Mueller M., Gehring W. J., Wuethrich K. RT The structure of the Antennapedia homeodomain determined RT ny NMR spectroscopy in solution: comparison with prokaryotic repressors RL Cell 59:573-580 (1989). RN [23] RA Otting G., Qian Y. Q., Billeter M., Mueller M., Affolter RA M., Gehring W. J., Wuethrich K. RT Protein-DNA contacts in the structure of a homeodomain-DNA RT complex determined by nuclear magnetic resonance spectroscopy in solution RL EMBO J. 9:3085-3092 (1990). XX // AC T00027 XX ID T00027 XX DT 15.10.92 (created); ewi. XX FA AP-1 XX SY (Jun)2; AP1; Fos/Jun; PEA1; XX OS clawed frog, Xenopus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CL C0008; bZIP; . XX CP (oocytes) XX MX M00173; V$AP1_Q2 MX M00199; V$AP1_C XX BS R02120; AP1$CONS; Quality: 6 XX RN [1] RA Richter J. D. RT In vivo photocrosslinking reveals that transcription RT factor binding to the mammalian ATF recognition sequence RT is required for E1A-induced transactivation in injected RT Xenopus laevis oocytes RL Nucleic Acids Res. 17:4503-4516 (1989). XX // AC T00028 XX ID T00028 XX DT 15.10.92 (created); ewi. DT 22.07.94 (updated); dhawale & lane; ewi. XX FA AP-1 XX SY (Jun)2; AP1; Fos/Jun; PEA1 (mouse); yAP1; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0008; bZIP; 1.1.1.5.3. XX SZ 35-47 kDa XX FF involved in response to oxidative stress / oxygen FF detoxification and metal resistance; FF similar to, but different from GCN4 XX MX M00199; V$AP1_C XX BS R02120; AP1$CONS; Quality: 6 BS R01384; SV$SV40_16; Quality: 2; SV40, simian virus 40 BS R01385; SV$SV40_17; Quality: 2; SV40, simian virus 40 BS R01394; SV$SV40_26; Quality: 2; SV40, simian virus 40 BS R01412; SV$SV40_44; Quality: 2; SV40, simian virus 40 BS R03792; Y$TRX2_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R03793; Y$TRX2_02; Quality: 4; yeast, Saccharomyces cerevisiae XX RN [1] RA Wu A., Wemmie J. A., Edgington N. P., Goebl M., Guevara RA J. L., Moye-Rowley W. S. RT Yeast bZip proteins mediate pleiotropic drug and metal resistance RL J. Biol. Chem. 268:18850-18858 (1993). RN [2] RA Moye-Rowley S., Harshman K. D., Parker C. S. RT Yeast YAP1 encodes a novel form of the jun family RT of transcriptional activator proteins RL Genes Dev. 3:283-292 (1989). RN [3] RA Hertle K., Haase E., Brendel M. RT The SNQ3 gene of Saccharomyces cerevisiae confers RT hyper-resistance to several functionally unrelated chemicals RL Curr. Genet. 19:429-433 (1991). RN [4] RA Harshman K. D., Moye-Rowley W. S., Parker C. S. RT Transcriptional Activation by the SV40 AP-1 Recognition RT Element in Yeast Is Mediated by a Factor Similar to RT AP-1 That Is Distinct from GCN4 RL Cell 53:321-330 (1988). RN [5] RA Jones R. H., Moreno S., Nurse P., Jones N. C. RT Expression of the SV40 Promoter in Fission Yeast: RT Identification and Characterization of an AP-1-like Factor RL Cell 53:659-667 (1988). XX // AC T00029 XX ID T00029 XX DT 15.10.92 (created); ewi. DT 08.01.96 (updated); hiwi. XX FA AP-1 XX SY (Jun)2; AP1; Fos/Jun; PEA1 (mouse); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0008; bZIP; . XX SZ 47 kDa XX SF composed of two subunits: two Jun-peptides or one SF Jun- and one Fos-peptide (or relatives) XX FF down-modulated by glucocorticoids through direct interaction with GR XX IN T00333; GR; rat, Rattus norvegicus. IN T00334; GR; chick, Gallus gallus. IN T00335; GR; mouse, Mus musculus. IN T00336; GR; cat, Felis catus. IN T00337; GR alpha; human, Homo sapiens. IN T01920; GR beta; human, Homo sapiens. IN T01945; NF-ATc; human, Homo sapiens. IN T01946; NF-ATx; human, Homo sapiens. XX MX M00173; V$AP1_Q2 MX M00199; V$AP1_C XX BS R00341; AD$E3_03; Quality: 4; adenovirus type 2 BS R00343; AD$E3_05; Quality: 3; adenovirus type 2 BS R00345; AD$E3_07; Quality: 1; adenovirus type 2 BS R00368; AD$E4_22; Quality: 3; adenovirus type 5 BS R02120; AP1$CONS; Quality: 1 BS R03082; AS$AP1_03; Quality: 6 BS R01777; BKV$BKV_06; Quality: 4; BKV, human polyomavirus BK BS R01776; BKV$BKV_07; Quality: 4; BKV, human polyomavirus BK BS R00637; HBV$HBVE_08; Quality: 5; HBV, human hepatitis B virus BS R00805; HCMV$IE1_19; Quality: 4; hCMV, human cytomegalovirus BS R00806; HCMV$IE1_20; Quality: 4; hCMV, human cytomegalovirus BS R01910; HCMV$IEMP_01; Quality: 4; hCMV, human cytomegalovirus BS R00695; HIV1$HIV1_02; Quality: 3; HIV-1, human immunodeficiency virus type 1 BS R00736; HPV$HPV16_04; Quality: 4; HPV-16, human papilloma virus type 16 BS R00742; HPV$HPV16_10; Quality: 4; HPV-16, human papilloma virus type 16 BS R03489; HPV$HPV18_04; Quality: 3; HPV-18, human papilloma virus type 18 BS R03479; HS$ACT2_01; Quality: 4; human, Homo sapiens BS R02887; HS$AG_07; Quality: 4; human, Homo sapiens BS R03439; HS$AG_10; Quality: 4; human, Homo sapiens BS R03440; HS$AG_11; Quality: 4; human, Homo sapiens BS R03445; HS$ALDA_01; Quality: 5; human, Homo sapiens BS R02420; HS$BG_10; Quality: 1; human, Homo sapiens BS R00468; HS$CFOS_11; Quality: 2; human, Homo sapiens BS R00957; HS$CJUN_03; Quality: 1; human, Homo sapiens BS R00960; HS$CJUN_06; Quality: 1; human, Homo sapiens BS R00235; HS$CLASE_01; Quality: 2; human, Homo sapiens BS R02571; HS$CMYC_10; Quality: 3; human, Homo sapiens BS R03036; HS$DPOLA_01; Quality: 5; human, Homo sapiens BS R04127; HS$ET1_02; Quality: 3; human, Homo sapiens BS R04125; HS$GFAP_04; Quality: 5; human, Homo sapiens BS R03522; HS$IL2_12; Quality: 3; human, Homo sapiens BS R01036; HS$MT2A_07; Quality: 2; human, Homo sapiens BS R01037; HS$MT2A_08; Quality: 2; human, Homo sapiens BS R02028; HS$NPY_03; Quality: 5; human, Homo sapiens BS R03352; HS$PAI_04; Quality: 5; human, Homo sapiens BS R01248; HS$PBGD_02; Quality: 4; human, Homo sapiens BS R01258; HS$PK_03; Quality: 2; human, Homo sapiens BS R02788; HS$PL_06; Quality: 4; human, Homo sapiens BS R03059; HS$STROM_02; Quality: 4; human, Homo sapiens BS R02413; HS$TCRBL_02; Quality: 4; human, Homo sapiens BS R01729; HS$TGFB1_04; Quality: 4; human, Homo sapiens BS R01730; HS$TGFB1_05; Quality: 4; human, Homo sapiens BS R00126; MOUSE$A1ANTR_02; Quality: 4; mouse, Mus musculus BS R00133; MOUSE$AP2_01; Quality: 2; mouse, Mus musculus BS R03386; MOUSE$JUND_06; Quality: 4; mouse, Mus musculus BS R02340; MOUSE$SCC_01; Quality: 4; mouse, Mus musculus BS R01461; MOUSE$TTPA_01; Quality: 4; mouse, Mus musculus BS R01223; PA$PY_05; Quality: 2; Py, polyoma virus BS R01239; PA$PY_21; Quality: 2; Py, polyoma virus BS R02378; RAT$CCK_01; Quality: 4; rat, Rattus norvegicus BS R00954; RAT$JE_01; Quality: 4; rat, Rattus norvegicus BS R01383; SV$SV40_15; Quality: 2; SV40, simian virus 40 BS R01386; SV$SV40_18; Quality: 1; SV40, simian virus 40 BS R01394; SV$SV40_26; Quality: 2; SV40, simian virus 40 BS R01412; SV$SV40_44; Quality: 2; SV40, simian virus 40 BS R01567; VIV$VISNA_03; Quality: 4; Visna virus XX DR Compel: C00072 DR Compel: C00073 DR Compel: C00085 DR Compel: C00113 DR Compel: C00115 DR Compel: C00116 XX RN [1] RA Jarman A. P., Wood W. G., Sharpe J. A., Gourdon G., Ayyub H., Higgs D. R. RT Characterization of the major regulatory element upstream RT of the human alpha-globin gene cluster RL Mol. Cell. Biol. 11:4679-4689 (1991). RN [2] RA Angel P., Hattori K., Smeal T., Karin M. RT The jun Proto-Oncogene Is Positively Autoregulated by Its Product, Jun/AP-1 RL Cell 55:875-885 (1988). RN [3] RA Mitchell P., Wang C., Tjian R. RT Positive and Negative Regulation of Transcription RT In Vitro: Enhancer-Binding Protein AP-2 Is Inhibited by SV40 T Antigen RL Cell 50:847-861 (1987). RN [4] RA Mermod N., Williams T. J., Tjian R. RT Enhancer binding factors AP-4 and AP-1 act in concert RT to activate SV40 late transcription in vitro RL Nature 332:557-561 (1988). RN [5] RA Sassone-Corsi P., Lamph W. W., Kamps M., Verma I. M. RT fos-associated cellular p39 is related to nuclear transcription factor AP-1 RL Cell 54:553-560 (1988). RN [6] RA Comb M., Mermod N., Hyman S. E., Pearlberg J., Ross M. E., Goodman H. M. RT Proteins bound adjacent DNA elements act synergistically RT to regulate human proenkephalin cAMP inducible transcription RL EMBO J. 7:3793-3805 (1988). RN [7] RA Grayson D. R., Costa R. H., Xanthopoulos K. G., Darnell J. E. RT One Factor Recognizes the Liver-Specific Enhancers RT in alpha1-Antitrypsin and Transthyretin Genes RL Science 239:786-788 (1988). RN [8] RA Bohmann D., Bos T. J., Admon A., Nishimura T., Vogt P. K., Tjian R. RT Human proto-oncogene c-jun encodes a DNA binding protein RT with structural and functional properties of transcription factor AP-1 RL Science 238:1386-1392 (1987). RN [9] RA Bos T. J., Bohmann D., Tsuchie H., Tjian R., Vogt P. K. RT v-jun encodes a nuclear protein with enhancer binding properties of AP-1 RL Cell 52:705-712 (1988). RN [10] RA Lucero M. A., Sanchez D., Ochoa A. R., Brunel F., RA Cohen G. N., Baralle F. E., Zakin M. M. RT Interaction of DNA-binding proteins with the tissue-specific RT human apolipoprotein-AII enhancer RL Nucleic Acids Res. 17:2283-2300 (1989). RN [11] RA Fink J. S., Verhave M., Kasper S., Tsukada T., Mandel G., Goodman R. H. RT The CGTCA sequence motif is essential for biological RT activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer RL Proc. Natl. Acad. Sci. USA 85:6662-6666 (1988). RN [12] RA Gabuzda D. H., Hess J. L., Small J. A., Clements J. E. RT Regulation of the Visna Virus Long Terminal Repeat RT in Macrophages Involves Cellular Factors That Bind RT Sequences Containing AP-1 Sites RL Mol. Cell. Biol. 9:2728-2733 (1989). RN [13] RA Lee W., Mitchell P., Tjian R. RT Purified Transcription Factor AP-1 Interacts with RT TPA-Inducible Enhancer Elements RL Cell 49:741-752 (1987). RN [14] RA Angel P., Imagawa M., Chiu R., Stein B., Imbra R. RA J., Rahmsdorf H. J., Jonat C., Herrlich P., Karin M. RT Phorbol ester-inducible genes contain a common cis RT element recognized by a TPA-modulated trans-acting factor RL Cell 49:729-739 (1987). RN [15] RA Gutman A., Wasylyk B. RT The collagenase gene promoter contains a TPA and oncogene-responsive RT unit encompassing the PEA3 and AP-1 binding sites RL EMBO J. 9:2241-2246 (1990). RN [16] RA Mignotte V., Eleouet J. F., Raich N., Romeo P.-H. RT Cis- and trans-acting elements involved in the regulation RT of the erythroid promoter of the human porphobilinogen deaminase gene RL Proc. Natl. Acad. Sci. USA 86:6548-6552 (1989). RN [17] RA Stein B., Rahmsdorf H. J., Steffen A., Litfin M., Herrlich P. RT UV-Induced DNA Damage Is an Intermediate Step in UV-Induced RT Expression of Human Immunodeficiency Virus Type 1 RT Collagenase, c-fos and Metallothionein RL Mol. Cell. Biol. 9:5169-5181 (1989). RN [18] RA Garcia J., Wu F., Gaynor R. RT Upstream regulatory regions required to stabilize RT binding to the TATA sequence in an adenovirus early promoter RL Nucleic Acids Res. 15:8367-8385 (1987). RN [19] RA Shaw P. E., Frasch S., Nordheim A. RT Repression of c-fos transcription is mediated through p6SRF bound to the SRE RL EMBO J. 8:2567-2574 (1989). RN [20] RA Shelbourn S. L., Kothari S. K., Sissons J. G. P., Sinclair J. H. RT Repression of human cytomegalovirus gene expression RT associated with a novel immediate early regulatory region binding factor RL Nucleic Acids Res. 17:9165ff (1989). RN [21] RA Takimoto M., Quinn J. P., Farina A. R., Staudt L. M., Levens D. RT fos/jun and Octamer-binding Protein Interact with RT a Common Site in a Negative Element of the Human c-myc Gene RL J. Biol. Chem. 264:8982-8999 (1989). RN [22] RA Hay N., Takimoto M., Bishop J. M. RT A FOS protein is present in a complex that binds a negative regulator of MYC RL Genes Dev. 3:293-303 (1989). RN [23] RA Trujillo M. A., Letovsky J., Maguire H. F., Lopez-Cabrera M., Siddiqui A. RT Functional analysis of a liver-specific enhancer of the hepatitis B virus RL Proc. Natl. Acad. Sci. USA 88:3797-3801 (1991). RN [24] RA de Groot R. P., Karperien M., Pals C., Kruijer W. RT Characterization of the mouse junD promoter - high RT basal level activity due to an octamer motif RL EMBO J. 10:2523-2532 (1991). RN [25] RA Karpinski B. A., Yang L.-H., Cacheris P., Morle G. D., Leiden J. M. RT The First Intron of the 4F2 Heavy-Chain Gene Contains RT a Transcriptional Enhancer Element That Binds Multiple Nuclear Proteins RL Mol. Cell. Biol. 9:2588-2597 (1989). RN [26] RA Jonat C., Rahmsdorf H. J., Park K.-K., Cato A. C. RA B., Gebel S., Ponta H., Herrlich P. RT Antitumor promotion and antiinflammation: Down-modulation RT of AP-1 (Fos/Jun) activity by glucocorticoid hormone RL Cell 62:1189-1204 (1990). XX // AC T00030 XX ID T00030 XX DT 15.10.92 (created); ewi. DT 08.01.96 (updated); hiwi. XX FA AP-1 XX SY (Jun)2; AP1; Fos/Jun; PEA1 (mouse); XX OS monkey, Cercopithecus aethiops OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; primates; haplorhini; OC catarrhini; cercopithecidae; cercopithecinae XX CL C0008; bZIP; . XX SZ 44-45 kDa (SDS) XX SF Phosphorylation XX CP (COS-7) XX MX M00173; V$AP1_Q2 MX M00199; V$AP1_C XX BS R02120; AP1$CONS; Quality: 6 BS R00903; RAT$INS_06; Quality: 4; rat, Rattus norvegicus XX RN [1] RA Nir U., Fodor E., Rutter W. J. RT Capturing Nuclear Sequence-Specific DNA-Binding Proteins RT by Using Simian Virus 40-Derived Minichromosomes RL Mol. Cell. Biol. 8:982-987 (1988). RN [2] RA Angel P., Allegretto E. A., Okino S. T., Hattori K., RA Boyle W. J., Hunter T., Karin M. RT Oncogene jun encodes a sequence-specific trans-activator similar to AP-1 RL Nature 332:166-171 (1988). XX // AC T00031 XX ID T00031 XX DT 15.10.92 (created); ewi. XX FA AP-1 XX SY (Jun)2; AP1; Fos/Jun; PEA1 (mouse); XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; . XX MX M00173; V$AP1_Q2 MX M00199; V$AP1_C XX BS R02120; AP1$CONS; Quality: 6 BS R00637; HBV$HBVE_08; Quality: 5; HBV, human hepatitis B virus BS R02788; HS$PL_06; Quality: 4; human, Homo sapiens BS R03059; HS$STROM_02; Quality: 1; human, Homo sapiens BS R00126; MOUSE$A1ANTR_02; Quality: 4; mouse, Mus musculus BS R00133; MOUSE$AP2_01; Quality: 2; mouse, Mus musculus BS R02340; MOUSE$SCC_01; Quality: 4; mouse, Mus musculus BS R00578; RAT$A2UG_06; Quality: 4; rat, Rattus norvegicus BS R02648; RAT$GSTP_01; Quality: 5; rat, Rattus norvegicus BS R00903; RAT$INS_06; Quality: 4; rat, Rattus norvegicus BS R02573; RAT$ME_03; Quality: 4; rat, Rattus norvegicus BS R01460; RAT$TS_01; Quality: 4; rat, Rattus norvegicus XX DR Compel: C00071 DR Compel: C00076 XX RN [1] RA Choy H. A., McLaughlin M., Feigelson P. RT Nuclear Factors from Expressing Tissues Interact in RT Vitro with with a Rat alpha-2u Globulin Gene Intron RL J. Biol. Chem. 264:1754-1759 (1989). XX // AC T00032 XX ID T00032 XX DT 15.10.92 (created); ewi. DT 11.05.95 (updated); ewi. XX FA AP-1 XX SY (Jun)2; AP1; Fos/Jun; PEA1; PEA1 (mouse); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; . XX FF AP-1 level decreases in murine mammary epithelial FF cells upon differentiation induced by dexamethasone or prolactin [8]; XX IN T01944; NF-ATp; mouse, Mus musculus. XX MX M00173; V$AP1_Q2 MX M00199; V$AP1_C XX BS R02120; AP1$CONS; Quality: 1 BS R02887; HS$AG_07; Quality: 4; human, Homo sapiens BS R03445; HS$ALDA_01; Quality: 5; human, Homo sapiens BS R00934; HS$IL2_05; Quality: 1; human, Homo sapiens BS R01037; HS$MT2A_08; Quality: 2; human, Homo sapiens BS R01248; HS$PBGD_02; Quality: 4; human, Homo sapiens BS R01564; HS$VIMEN_01; Quality: 4; human, Homo sapiens BS R02674; MOUSE$A1PI_01; Quality: 4; mouse, Mus musculus BS R02676; MOUSE$A1PI_03; Quality: 4; mouse, Mus musculus BS R00133; MOUSE$AP2_01; Quality: 2; mouse, Mus musculus BS R01736; MOUSE$CMYB_02; Quality: 5; mouse, Mus musculus BS R02952; MOUSE$IL2_04; Quality: 4; mouse, Mus musculus BS R02953; MOUSE$IL2_05; Quality: 4; mouse, Mus musculus BS R01050; MOUSE$M1H2DD_01; Quality: 1; mouse, Mus musculus BS R01052; MOUSE$M1H2DD_03; Quality: 1; mouse, Mus musculus BS R01062; MOUSE$M1H2KB_10; Quality: 2; mouse, Mus musculus BS R01287; MOUSE$PLF_03; Quality: 4; mouse, Mus musculus BS R02340; MOUSE$SCC_01; Quality: 4; mouse, Mus musculus BS R03300; MOUSE$TIMP_01; Quality: 4; mouse, Mus musculus BS R01220; PA$PY_02; Quality: 4; Py, polyoma virus BS R01225; PA$PY_07; Quality: 4; Py, polyoma virus XX DR Compel: C00090 DR Compel: C00091 DR Compel: C00108 XX RN [1] RA Rittling S. R., Coutinho L., Amram T., Kolbe M. RT Ap-1/jun binding sites mediate serum inducibility RT of the human vimentin promoter RL Nucleic Acids Res. 17:1619 (1989). RN [2] RA Korber B., Mermod N., Hood L., Stroynowski I. RT Regulation of Gene Expression by Interferons: Control RT of H-2 Promoter Responses RL Science 239:1302-1306 (1988). RN [3] RA Piette J., Yaniv M. RT Two different factors bind to the alpha-domain of RT the polyoma virus enhancer, one of which also interacts RT with the SV40 and c-fos enhancers RL EMBO J. 6:1331-1337 (1987). RN [4] RA Kryszke M.-H., Piette J., Yaniv M. RT Induction of a factor that binds to the polyoma virus RT A enhancer on differentiation of embryonal carcinoma cells RL Nature 328:254-256 (1987). RN [5] RA Martin M. E., Piette J., Yaniv M., Tang W.-J., Folk W. R. RT Activator of the polyomavirus enhancer by a murine RT activator protein 1 (AP1) homolog and two contiguous proteins RL Proc. Natl. Acad. Sci. USA 85:5839-5843 (1988). RN [6] RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription RT factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [7] RA Mignotte V., Wall L., deBoer E., Grosveld F., Romeo P.-H. RT Two tissue-specific factors bind to the erythroid RT promoter of the human porphobilinogen deaminase gene RL Nucleic Acids Res. 17:37-54 (1989). RN [8] RA Jehn B., Costello E., Marti A., Keon N., Deane R., RA Li F., Friis R. R., Burri P. H., Martin F., Jaggi R. RT Overexpression of Mos, Ras, Src, and Fos inhibits RT mouse mammary epithelial cell differentiation RL Mol. Cell. Biol. 12:3890- 3902 (1992). RN [9] RA Campbell C. E., Flenniken A. M., Skup D., Williams B. R. G. RT Identification of a serum- and phorbol ester-responsive RT element in the murine tissue inhibitor of metalloproteinase gene RL J. Biol. Chem. 266:7199-7206 (1991). XX // AC T00033 XX ID T00033 XX DT 25.01.93 (created); hse. DT 08.01.96 (updated); hiwi. XX FA AP-2 XX SY AP2; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 50 kDa (SDS) XX SF helix-turn-helix XX CP neural crest lineage cells XX BS R02121; AP2$CONS; Quality: 6 BS R01054; MOUSE$M1H2KB_02; Quality: 1; mouse, Mus musculus XX RN [1] RA Courtois S. J., Lafontaine D. A., Lemaigre F. P., RA Durviaux S. M., Rousseau G. G. RT Nuclear factor-I and activator protein-2 bind in a RT mutually exclusive way to overlapping promoter sequences RT and trans-activate the human growth hormone gene RL Nucleic Acids Res. 18:57-64 (1990). RN [2] RA Williams T., Tjian R. RT Analysis of the DNA-binding and activation properties RT of the human transcription factor AP-2 RL Genes Dev. 5:670-682 (1991). RN [3] RA Mitchell P. J., Timmons P. M., Hebert J. M., Rigby P. W., Tjian R. RT Transcription factor AP-2 is expressed in neural creast RT cell lineages during mouse embryogenesis RL Genes Dev. 5:105-119 (1991). RN [4] RA Comb M., Goodman H. M. RT CpG methylation inhibits proenkephalin gene expression RT and binding of the transcription factor AP-2 RL Nucleic Acids Res. 18:3975-3982 (1990). XX // AC T00034 XX ID T00034 XX DT 25.01.93 (created); hse. DT 08.01.96 (updated); hiwi. XX FA AP-2 XX SY AP2; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 50 kDa (SDS) XX SF helix-turn-helix XX CP neural crest lineage cells XX BS R02121; AP2$CONS; Quality: 6 BS R04035; HS$FN_08; Quality: 5; human, Homo sapiens BS R00607; HS$GRH_01; Quality: 1; human, Homo sapiens BS R01563; RAT$VASO_01; Quality: 5; rat, Rattus norvegicus XX RN [1] RA Courtois S. J., Lafontaine D. A., Lemaigre F. P., RA Durviaux S. M., Rousseau G. G. RT Nuclear factor-I and activator protein-2 bind in a RT mutually exclusive way to overlapping promoter sequences RT and trans-activate the human growth hormone gene RL Nucleic Acids Res. 18:57-64 (1990). RN [2] RA Williams T., Tjian R. RT Analysis of the DNA-binding and activation properties RT of the human transcription factor AP-2 RL Genes Dev. 5:670-682 (1991). RN [3] RA Mitchell P. J., Timmons P. M., Hebert J. M., Rigby P. W., Tjian R. RT Transcription factor AP-2 is expressed in neural creast RT cell lineages during mouse embryogenesis RL Genes Dev. 5:105-119 (1991). RN [4] RA Winning R. S., Shea L. J., Marcus S. J., Sargent T. D. RT Developmental regulation of transcription factor AP-2 RT during Xenopus laevis embryogenesis RL Nucleic Acids Res. 19:3709-3714 (1991). RN [5] RA Comb M., Goodman H. M. RT CpG methylation inhibits proenkephalin gene expression RT and binding of the transcription factor AP-2 RL Nucleic Acids Res. 18:3975-3982 (1990). XX // AC T00035 XX ID T00035 XX DT 15.10.92 (created); ewi. DT 22.08.96 (updated); ewi. XX FA AP-2 XX SY AP2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 437 AA; 48.1 kDa (cDNA), 50, 52 kDa (SDS) XX SQ MLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPP SQ PYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSG SQ LDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPV SQ SLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSP SQ PECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHL SQ ARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLG SQ NSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNS SQ HTDNNAKSSDKEEKHRK XX SC SwissProt #P05549 XX SF Helix-Span-Helix SF proline-rich region, glutamine-rich region XX CP (HeLa) XX BS R02121; AP2$CONS; Quality: 1 BS R00183; BPV1$BPV1_13; Quality: 1; BPV-1, bovine papilloma virus type 1 BS R03661; HS$APOB_10; Quality: 5; human, Homo sapiens BS R03666; HS$APOB_15; Quality: 5; human, Homo sapiens BS R00958; HS$CJUN_04; Quality: 6; human, Homo sapiens BS R00959; HS$CJUN_05; Quality: 1; human, Homo sapiens BS R02462; HS$CLASET4_01; Quality: 4; human, Homo sapiens BS R01157; HS$CMYC_01; Quality: 1; human, Homo sapiens BS R01158; HS$CMYC_02; Quality: 1; human, Homo sapiens BS R02425; HS$CREBP1_03; Quality: 5; human, Homo sapiens BS R04379; HS$CYCB1_02; Quality: 5; human, Homo sapiens BS R04125; HS$GFAP_04; Quality: 5; human, Homo sapiens BS R04126; HS$GFAP_05; Quality: 5; human, Homo sapiens BS R00607; HS$GRH_01; Quality: 1; human, Homo sapiens BS R00608; HS$GRH_02; Quality: 1; human, Homo sapiens BS R01031; HS$MT2A_02; Quality: 2; human, Homo sapiens BS R01032; HS$MT2A_03; Quality: 1; human, Homo sapiens BS R01034; HS$MT2A_05; Quality: 1; human, Homo sapiens BS R01035; HS$MT2A_06; Quality: 1; human, Homo sapiens BS R04415; HS$ODC_01; Quality: 4; human, Homo sapiens BS R01261; HS$PK_05; Quality: 1; human, Homo sapiens BS R02795; HS$TCRA_03; Quality: 5; human, Homo sapiens BS R02698; HT1$HTLV1_10; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R02701; HT1$HTLV1_13; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R02702; HT1$HTLV1_14; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R01054; MOUSE$M1H2KB_02; Quality: 1; mouse, Mus musculus BS R01055; MOUSE$M1H2KB_03; Quality: 2; mouse, Mus musculus BS R04414; RAT$PTHYA_01; Quality: 1; rat, Rattus norvegicus BS R01390; SV$SV40_22; Quality: 4; SV40, simian virus 40 BS R01404; SV$SV40_36; Quality: 1; SV40, simian virus 40 XX DR EMBL: X52611; HSAP2(r). DR SwissProt: P05549; AP2_HUMAN. DR PIR: A31752; A31752. XX RN [1] RA Angel P., Hattori K., Smeal T., Karin M. RT The jun Proto-Oncogene Is Positively Autoregulated by Its Product, Jun/AP-1 RL Cell 55:875-885 (1988). RN [2] RA Mitchell P., Wang C., Tjian R. RT Positive and Negative Regulation of Transcription RT In Vitro: Enhancer-Binding Protein AP-2 Is Inhibited by SV40 T Antigen RL Cell 50:847-861 (1987). RN [3] RA Comb M., Mermod N., Hyman S. E., Pearlberg J., Ross M. E., Goodman H. M. RT Proteins bound adjacent DNA elements act synergistically RT to regulate human proenkephalin cAMP inducible transcription RL EMBO J. 7:3793-3805 (1988). RN [4] RA Mercurio F., Karin M. RT Transcription factors AP-3 and AP-2 interact with RT the SV40 enhancer in a mutually exclusive manner RL EMBO J. 8:1455-1460 (1989). RN [5] RA Chiu R., Imagawa M., Imbra R. J., Bockoven J. R., Karin M. RT Multiple cis- and trans-acting elements mediate the RT transcriptional response to phorbol esters RL Nature 329:648-651 (1987). RN [6] RA Imagawa M., Chiu R., Karin M. RT Transcription factor AP-2 mediates induction by two RT different signal transduction pathways: Protein kinase C and cAMP RL Cell 51:251-260 (1987). RN [7] RA Williams T., Admon A., Luescher B., Tjian R. RT Cloning and expression of AP-2, a cell-type-specific RT transcription factor that activates inducible enhancer elements RL Genes Dev. 2:1557-1569 (1988). RN [8] RA Courtois S. J., Lafontaine D. A., Lemaigre F. P., RA Durviaux S. M., Rousseau G. G. RT Nuclear factor-I and activator protein-2 bind in a RT mutually exclusive way to overlapping promoter sequences RT and trans-activate the human growth hormone gene RL Nucleic Acids Res. 18:57-64 (1990). RN [9] RA Williams T., Tjian R. RT Analysis of the DNA-binding and activation properties RT of the human transcription factor AP-2 RL Genes Dev. 5:670-682 (1991). RN [10] RA Mitchell P. J., Timmons P. M., Hebert J. M., Rigby P. W., Tjian R. RT Transcription factor AP-2 is expressed in neural creast RT cell lineages during mouse embryogenesis RL Genes Dev. 5:105-119 (1991). RN [11] RA Comb M., Goodman H. M. RT CpG methylation inhibits proenkephalin gene expression RT and binding of the transcription factor AP-2 RL Nucleic Acids Res. 18:3975-3982 (1990). XX // AC T00036 XX ID T00036 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA AP-4 XX SY AP4; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO GT-IIBalpha, GT-IIBbeta XX CL C0012; bHLH-ZIP; 1.3.1.4.1. XX SZ >321 AA; >36.7 kDa (cDNA), 48 kDa (SDS) XX SQ RKTEKEVIGGLCSLANIPLTPETQRDQERRIRREIANSNERRRMQSINAGFQSLKTLIPH SQ TDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGI SQ GSPDIWEDEKAEDLRREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQL SQ QQQQEQVRLLHQEKLEREQQQLRTQLLPPPAPTHHPTVIVPAPPPPPSHHINVVTMGPSS SQ VINSVSTSRQNLDTIVQAIQHIEGTQEKQELEEEQRRAVIVKPVRSCPEAPTSDTASDSE SQ ASDSDAMDQSREEPSGDGELP XX SC SwissProt #Q01664 XX FT 29 43 basic region FT 44 83 helix-loop-helix domain FT 82 103 leucine zipper 1(L4 c-Myc-like) FT 134 162 leucine zipper 2 (L2EL2 c-Jun-like) FT 176 205 glutamine-rich region FT 208 227 proline-rich region FT 270 319 acidic region XX SF leucine zipper structures are dispensable for DNA-binding, SF but are required for dimerization in the absence of DNA [4]; SF ZIP 2 mainly supports homodimerization, but may be substituted by ZIP 1 SF heterodimerization with E12 only after truncation SF of both leucine zipper motifs [4]; XX FF functional interaction with AP-1 XX IN T00036; AP-4; human, Homo sapiens. IN T00204; E12; human, Homo sapiens. IN T00675; E12; rat, Rattus norvegicus. IN T01787; E12; clawed frog, Xenopus laevis. XX MX M00005; V$AP4_01 XX BS R02123; AP4$CONS; Quality: 2 BS R02076; AS$AP4_01; Quality: 2 BS R01038; HS$MT2A_09; Quality: 6; human, Homo sapiens BS R01259; HS$PK_04; Quality: 6; human, Homo sapiens BS R01227; PA$PY_09; Quality: 6; Py, polyoma virus BS R01240; PA$PY_22; Quality: 6; Py, polyoma virus BS R02378; RAT$CCK_01; Quality: 5; rat, Rattus norvegicus BS R01416; SV$SV40_48; Quality: 6; SV40, simian virus 40 BS R01567; VIV$VISNA_03; Quality: 5; Visna virus XX DR EMBL: X57435; HSTFAP(r). DR SwissProt: Q01664; TAP4_HUMAN. DR PIR: A36394; A36394. XX RN [1] RA Mermod N., Williams T. J., Tjian R. RT Enhancer binding factors AP-4 and AP-1 act in concert RT to activate SV40 late transcription in vitro RL Nature 332:557-561 (1988). RN [2] RA Comb M., Mermod N., Hyman S. E., Pearlberg J., Ross M. E., Goodman H. M. RT Proteins bound adjacent DNA elements act synergistically RT to regulate human proenkephalin cAMP inducible transcription RL EMBO J. 7:3793-3805 (1988). RN [3] RA Mermod N., O'Neill E. A., Kelly T. J., Tjian R. RT The Proline-Rich Transcriptional Activator of CTF/NF-I RT Is Distinct from the Replication and DNA Binding Domain RL Cell 58:741-753 (1989). RN [4] RA Hu Y. F., Luescher B., Admon A., Mermod N., Tjian R. RT Transcription factor AP-4 contains multiple dimerization RT domains that regulate dimer specificity RL Genes Dev. 4:1741-1752 (1990). RN [5] RA Dang C. V., Dolde C., Gillison M. L., Kato G. J. RT Discrimination between related DNA sites by a single RT amino acid residue of Myc-related basic-helix-loop-helix proteins RL Proc. Natl. Acad. Sci. USA 89:599-602 (1992). XX // AC T00037 XX ID T00037 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA AP-5 XX SY AP5; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO TEF-1 XX SZ 50 kDa XX CP (HeLa) XX BS R03900; RAT$BMHC_02; Quality: 5; rat, Rattus norvegicus BS R01417; SV$SV40_49; Quality: 6; SV40, simian virus 40 XX RN [1] RA Mercurio F., Karin M. RT Transcription factors AP-3 and AP-2 interact with RT the SV40 enhancer in a mutually exclusive manner RL EMBO J. 8:1455-1460 (1989). XX // AC T00038 XX ID T00038 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA AP-3 (1) XX SY AP3; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO TEF-2 XX CP (HeLa) XX FF different from AP3 (2) (Ref. 160) XX BS R01411; SV$SV40_43; Quality: 6; SV40, simian virus 40 XX RN [1] RA Mitchell P., Wang C., Tjian R. RT Positive and Negative Regulation of Transcription RT In Vitro: Enhancer-Binding Protein AP-2 Is Inhibited by SV40 T Antigen RL Cell 50:847-861 (1987). RN [2] RA Chiu R., Imagawa M., Imbra R. J., Bockoven J. R., Karin M. RT Multiple cis- and trans-acting elements mediate the RT transcriptional response to phorbol esters RL Nature 329:648-651 (1987). XX // AC T00039 XX ID T00039 XX DT 15.10.92 (created); ewi. DT 25.01.93 (updated); hse. XX FA AP-3 (2) XX SY AP3; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 48/57 kDa (SDS) XX FF apparently different from AP3 (1) (Ref. 110) XX BS R02122; AP3$CONS; Quality: 2 BS R02951; MOUSE$IL2_03; Quality: 6; mouse, Mus musculus BS R03696; MOUSE$IL2_06; Quality: 2; mouse, Mus musculus BS R03697; MOUSE$IL2_07; Quality: 2; mouse, Mus musculus BS R03698; MOUSE$IL2_08; Quality: 2; mouse, Mus musculus BS R01395; SV$SV40_27; Quality: 6; SV40, simian virus 40 BS R01398; SV$SV40_30; Quality: 6; SV40, simian virus 40 XX RN [1] RA Mercurio F., Karin M. RT Transcription factors AP-3 and AP-2 interact with RT the SV40 enhancer in a mutually exclusive manner RL EMBO J. 8:1455-1460 (1989). RN [2] RA Emmel E. A., Verweij C. L., Durand D. B., Higgins RA K. M., Lacy E., Crabtree G. R. RT Cyclosporin A specifically inhibits function of nuclear RT proteins involved in T cell activation RL Science 246:1617-1620 (1989). XX // AC T00040 XX ID T00040 XX DT 25.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA AR XX SY androgen receptor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); 2.1.1.3.1. XX SZ 919 AA; 99.0 kDa (cDNA), 110-112 kDa (SDS) [3]; XX SQ MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ SQ QQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSA SQ LECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLK SQ DILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKA SQ VSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKS SQ TEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSR SQ DYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGP SQ GSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPY SQ GYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLE SQ TARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRND SQ CTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLT SQ VSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK SQ ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRM SQ YSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDR SQ IIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIIS SQ VQVPKILSGKVKPIYFHTQ XX SC SwissProt #P10275 XX FT 1 556 region A/B FT 556 623 region C, DNA-binding domain (DBD) FT 624 665 region D FT 617 658 bipartite nuclear targeting signal [4], [5]; FT 666 919 region E, hormone-binding domain (HBD) XX SF androgen exposure required for dimerization and subsequent DNA-binding SF dimerization inhibited by region A/B [1]; SF nuclear uptake may occur constitutively [3] as well SF as hormone-dependent [4], [5]; SF there may be tissue-specific splice variants [6]; XX FF by binding to androgen-responsive elements, AR regulates FF expression of target genes [10], [1]; XX IN T00040; AR; human, Homo sapiens. IN T00992; Hsp90; human, Homo sapiens. XX BS R02124; AR$CONS; Quality: 6 XX DR EMBL: M20132; HSANDREC(r). DR SwissProt: P10275; ANDR_HUMAN. DR PIR: A34942; A34942. DR PIR: A39248; A39248. XX RN [1] RA Wong C.-i., Zhou Z.-x., Sar M., Wilson E. M. RT Steroid requirement for androgen receptor dimerization RT and DNA binding. Modulation by intramolecular interactions RT between the NH2-terminal and steroid-binding domains RL J. Biol. Chem. 268:19004-19012 (1993). RN [2] RA Lubahn D. B., Joseph D. R., Sullivan P. M., Willard RA H. F., French F. S., Wilson E. M. RT Cloning of the human androgen receptor complementary RT DNA and localization to the X chromosome RL Science 240:327-330 (1988). RN [3] RA Jenster G., van der Korput H. A. G. M., van Vroonhoven RA C., van der Kwast T. H., Trapman J., Brinkmann A. O. RT Domains of the human androgen receptor involved in RT steroid binding, transcriptional activation, and subcellular localization RL Mol. Endocrinol. 5:1396-1404 (1991). RN [4] RA Simental J. A., Sar M., Lane M. V., French F. S., Wilsion E. RT Transcriptional activation and nuclear targeting signals RT of the human androgen receptor RL J. Biol. Chem. 266:510-518 (1991). RN [5] RA Zhou Z.-x., Sar M., Simantal J. A., Lane M. V., Wilson E. M. RT A ligand-dependent bipartite nuclear targeting signal RT in the human androgen receptor RL J. Biol. Chem. 269:13115-13123 (1994). RN [6] RA Faber P. W., van Rooij H. C., van der Korput H. A. RA G. M., Baarends W. M., Brinkmann A. O., Grootegoed J. A., Trapman J. RT Characterization of the human androgen receptor transcription unit RL J. Biol. Chem. 266:10743-10749 (1991). RN [7] RA Veldscholte J., Berrevoets C. A., Brinkmann A. O., RA Grootegoed J. A., Mulder E. RT Anti-androgens and mutated receptor of LNCaP cells: RT differential effects on binding affinity, heat-shock RT protein interaction, and transcription activation RL Biochemistry 31:2393-2399 (1992). RN [8] RA Chang C., Wang C., DeLuca H. F., Ross T. K., Shih C.C.-Y. RT Charactirization of human androgen receptor overexpressed RT in the baculovirus system RL Proc. Natl. Acad. Sci. USA 89:5946-5950 (1992). RN [9] RA Trapman J., Klaassen P., Kuiper G. G. J. M., van der RA Korput J. A. B. M., Faber P. W., van Rooij H. C. J., RA van Kessel A. G., Voorhorst M. M., Mulder E., Brinkmann A. O. RT Cloning, stucture and expression of a cDNA encoding RT the human androgen receptor RL Biochem. Biophys. Res. Commun. 153:241-248 (1988). RN [10] RA De Vos P., Claessens F., Winderickx J., Van Dijck RA P., Celis L., Peeters B., Rombauts W., Heyns W., Verhoeven G. RT Interaction of androgen response elements with the RT DNA-binding domain of the rat androgen receptor expressed RT in Escherichia coli RL J. Biol. Chem. 266:3439-3443 (1991). RN [11] RA Chang C., Kokontis J., Liao S. RT Molecular cloning of human and rat complementary DNA RT encoding androgen receptors RL Science 240:324-326 (1988). RN [12] RA Chang C., Kokontis J., Liao S. RT Structural analysis of complementary DNA and amino RT acid sequences of human and rat androgen receptors RL Proc. Natl. Acad. Sci. USA 85:7211-7215 (1988). RN [13] RA Tilley W., Marcelli M., Wilson J. D., McPhaul M. J. RT Characterization and expression of a cDNA encoding RT the human androgen receptor RL Proc. Natl. Acad. Sci. USA 86:327-331 (1989). RN [14] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). XX // AC T00041 XX ID T00041 XX DT 25.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA AR XX SY androgen receptor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.1.3.1. XX SZ 899 AA; 98.2 kDa (cDNA), 98.9 kDa (SDS) XX SQ MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAANIAPPGACLQQRQET SQ SPRRRRRQQHTEDGSPQAHIRGPTGYLALEEEQQPSQQQAASEGHPESSCLPEPGAATAP SQ GKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILNEAGTMQLLQQQQQQQ SQ QHQQQHQQHQQQQEVISEGSSARAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSM SQ GLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLPECKGLPLDEGPGKSTEETA SQ EYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGALDEAAAYQNRDYYNF SQ PLALSGPPHPPPPTHPHARIKLENPLDYGSAWAAAAAQCRYGDLGSLHGGSVAGPSTGSP SQ PATTSSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLTSQESDYSASE SQ VWYPGGVVNRVPYPSPNCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCL SQ ICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCY SQ EAGMTLGARKLKKLGNLKLQEEGENSNAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAI SQ EPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYS SQ WMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQIT SQ PQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLT SQ KLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ XX SC SwissProt #P19091 XX FT 1 536 region A/B FT 537 603 region C, DNA-binding domain (DBD) FT 604 645 region D FT 646 899 region E, hormone-binding domain (HBD) XX BS R02124; AR$CONS; Quality: 6 XX DR EMBL: M37890; MMANDR(r). DR EMBL: X53779; MMANDREC(r). DR EMBL: X59592; MMANREC(r). DR SwissProt: P19091; ANDR_MOUSE. DR PIR: A35895; A35895. DR PIR: A37255; A37255. DR PIR: A37908; A37908. DR PIR: S17198; S17198. XX RN [1] RA Faber P. W., King A., van Rooij H. C. J., Brinkmann A. O., de Both N. J. RT The mouse androgen receptor RL J. Biochem. 278:269-278 (1991). RN [2] RA He W. W., Fischer L. M., Sun S., Bilhartz D. L., Zhu RA X., Young C. Y. -F., Kelley D. B. RT Molecular cloning of androgen receptors from divergent RT species with a polymerase chain reaction technique: RT complete cDNA sequence of the mouse androgen receptor RT and isolation of androgen receptor cDNA probes from RT dog, guinea pig and clawed frog RL Biochem. Biophys. Res. Commun. 171:697-704 (1990). RN [3] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). XX // AC T00042 XX ID T00042 XX DT 25.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA AR XX SY androgen receptor; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.1.3.1. XX SZ 902 AA; 98.2 kDa (cDNA), 98.9 kDa (SDS) XX SQ MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAASIAPPGACLQQRQET SQ SPRRRRRQQHPEDGSPQAHIRGTTGYLALEEEQQPSQQQSASEGHPESGCLPEPGAATAP SQ GKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILSEAGTMQLLQQQQQQQ SQ QQQQQQQQQQQQQQQEVISEGSSSVRAREATGAPSSSKDSYLGGNSTISDSAKELCKAVS SQ VSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLAECKGLSLDEGPGKGTE SQ ETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGAVDEAAAYQNRDY SQ YNFPLALSGPPHPPPPTHPHARIKLENPSDYGSAWAAAAAQCRYGDLASLHGGSVAGPST SQ GSPPATASSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLASQEGDFS SQ ASEVWYPGGVVNRVPYPSPSCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQK SQ TCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLR SQ KCYEAGMTLGARKLKKLGNLKLQEEGENSSAGSPTEDPSQKMTVSHIEGYECQPIFLNVL SQ EAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVI SQ QYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWL SQ QITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFY SQ QLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH SQ TQ XX SC SwissProt #P15207 XX FT 540 606 region C, DNA-binding domain (DBD) XX FF regulates androgen-dependent gene expression by binding FF to androgen-responsive elements (ARE) [2]; XX BS R02124; AR$CONS; Quality: 6 BS R01101; MMTV$MMTV_03; Quality: 2; MMTV, mouse mammary tumor virus BS R03286; RAT$PRSTC3_01; Quality: 2; rat, Rattus norvegicus XX DR EMBL: M20133; RNANDREC(r). DR SwissProt: P15207; ANDR_RAT. DR PIR: A34943; A34943. XX RN [1] RA Danzo B. J., Parrot J. A., Skinner M. K. RT Analysis of the steroid binding domain of rat androgen-binding protein RL Endocrinology 129:690-696 (1991). RN [2] RA De Vos P., Claessens F., Winderickx J., Van Dijck RA P., Celis L., Peeters B., Rombauts W., Heyns W., Verhoeven G. RT Interaction of androgen response elements with the RT DNA-binding domain of the rat androgen receptor expressed RT in Escherichia coli RL J. Biol. Chem. 266:3439-3443 (1991). RN [3] RA Chang C., Kokontis J., Liao S. RT Structural analysis of complementary DNA and amino RT acid sequences of human and rat androgen receptors RL Proc. Natl. Acad. Sci. USA 85:7211-7215 (1988). RN [4] RA Tilley W., Marcelli M., Wilson J. D., McPhaul M. J. RT Characterization and expression of a cDNA encoding RT the human androgen receptor RL Proc. Natl. Acad. Sci. USA 86:327-331 (1989). RN [5] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). XX // AC T00043 XX ID T00043 XX DT 12.03.93 (created); ewi. DT 27.08.96 (updated); ewi. XX FA ARG RI XX SY ARG 80; ARGRI; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0014; MADS; 4.3.3.0.1. XX SZ 177 AA; 19.5 kDa (gene) XX SQ MTSNSDGSSTSPVEKPITGDVETNEPTKPIRRLSTPSPEQDQEGDFEEEDDDDKFSVSTS SQ TPTPTITKTKDSSDTSTVTRRKQPIRYIENKTRRHVTFSKRRHGIMKKAYELSVLTGANI SQ LLLILANSGLVYTFTTPKLEPVVREDEGKSLIRACINASDTPDATDTSPAQEQSPAN XX SC SwissProt #P07249 XX FT 80 135 MADS box XX SF does not interact with TCF (p62TCF) [2]; XX FF controls arginine metabolism: repressor of arginine FF syntheses, induces Arg catabolism [4]; XX IN T00672; p67; human, Homo sapiens. IN T00761; SRF; chick, Gallus gallus. IN T00762; SRF; cat, Felis catus. IN T00763; SRF; clawed frog, Xenopus laevis. IN T00764; SRF; human, Homo sapiens. IN T00765; SRF; mouse, Mus musculus. IN T00766; SRF; rat, Rattus norvegicus. XX BS R00466; HS$CFOS_09; Quality: 2; human, Homo sapiens BS R03057; Y$ARG56_01; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: X05327; SCARGI(g). DR SwissProt: P07249; ARG1_YEAST. DR PIR: S05822; RGBYGI. XX RN [1] RA Sharrocks A. D., Gille H., Shaw P. E. RT Identification of amino acids essential for DNA binding RT and dimerization in p67SRF: implications for a novel DNA-binding motif RL Mol. Cell. Biol. 13:123-132 (1993). RN [2] RA Mueller C. G. F., Nordheim A. RT A protein domain conserved between yeast MCM1 and RT human SRF directs ternary complex formation RL EMBO J. 10:4219-4229 (1991). RN [3] RA Dubois E., Bercy J., Messenguy F. RT Characterization of two genes, ARGRI and ARGRIII required RT for specific regulation of arginine metabolism in yeast RL Mol. Gen. Genet. 207:142-148 (1987). RN [4] RA Dubois E., Messenguy F. RT In vitro studies of the binding of the ARGR proteins to the ARG5,6 promoter RL Mol. Cell. Biol. 11:2162-2168 (1991). XX // AC T00044 XX ID T00044 XX DT 12.03.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA ARG RII XX SY ARG81; ARGRII; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0005; C6; 2.4.1.0.1. XX SZ 880 AA XX SQ MGIFSKNGPKKMGRAKTFTGCWTCRGRKVKCDLRHPHCQRCEKSNLPCGGYDIKLRWSKP SQ MQFDPYGVPIPQNSPATTTNLSGSVDEPQYQRRNIDFVRYDEEYVYHEDMDDELTMLHTP SQ PIEKISDNTWLIIKKFGVFKGTDKIDKQYAPRKKRNRKRVAKSLESSASISLSSLPSSST SQ ISFPIRHIEDKLRNKGHVKTGILSANDGVPPTPNLLDYDWNNLNITGYEWISSELRDDAL SQ LSAVTLQGHHLGHTQPQEISLEENSNVVSGEEHVNAKEHGCAVEADNQGSSTLPNKAASA SQ NDKLYQQNLKLLFQKNSSNSEEPDPQALIDDVFVNIEPRSLPASVLNKITLAPPNEESRM SQ PKSMLQLTSYSSDLPPELVDIIPKTDLTVHGLARFLLNHYFNNVADKMTVVVLEKNPWKT SQ LYFPRALMALGDLAGLGQSSNSRNALLNALLAVSCFHLQSKYPRNYKLQKYFLGLGIELR SQ NQASNFLRLCLNTKSSIPEKYKDVLTAILSMNSIDVVWGTMADCQDHLALCEDFVESRMK SQ LRPNISEKAKTLHRIFSFLKLIQDSTALDKVRAKEIVILPSEEDDNYKPLDTSNATSSSS SQ EPRVDVVQEGLFREALNENDGKIHIEFVKEPITNVSADSTPSSTTPPIFTNIATESYYNK SQ SDISNLVSKTDENIIGTDSLYGLPNSLILLFSDCVRIVRHNEYYNLTYLPVPRKFNELSL SQ NFEKRLLKWKSEWNFHQENSEGKSFINSTAEALYHHTMSFYFSLIIYYFTMARSLNCQFL SQ QNYVAKVLDHLNAMEELVDQKKVKIVPLIWQGFMAGCACTDENRQQEFRRWAAKLAESGV SQ GSYWGARQVMLEVWRRRKEDEPGDNWYSIYKDWEMNLMLS XX SC SwissProt #P05085 XX FT 21 48 zinc-binding FT 101 113 acidic region FT 564 630 acidic region FT 859 874 acidic region FT 426 444 helix-turn-helix ? FT 839 845 helix-turn-helix ? FT 133 203 RNase homology XX FF controls arginine metabolism; FF region AA 145-165 specifically required for catabolic genes XX BS R03057; Y$ARG56_01; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: X03940; SCARGRII(g). DR SwissProt: P05085; ARG2_YEAST. DR PIR: A25046; A25046. XX RN [1] RA Dubois E., Messenguy F. RT In vitro studies of the binding of the ARGR proteins to the ARG5,6 promoter RL Mol. Cell. Biol. 11:2162-2168 (1991). RN [2] RA Qiu H. F., Dubois E., Messenguy F. RT Dissection of the bifunctional ARGRII protein involved RT in the regulation of arginine anabolic and catabolic pathways RL Mol. Cell. Biol. 11:2169-2179 (1991). XX // AC T00045 XX ID T00045 XX DT 25.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA ARP-1 XX SY COUP-beta; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); . XX SZ 414 AA; 47 kDa (SDS), 45.6 kDa (cDNA) XX SQ MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQ SQ GGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN SQ CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSG SQ YISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITD SQ QVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVE SQ KLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRF SQ GKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ XX SC SwissProt #P24468 XX FT 1 78 proline-, glutamine-, glycine-rich region A/B FT 79 149 region C FT 150 176 region D FT 176 401 ligand-binding region E FT 337 414 dimerization domain FT 401 414 region F XX CP widespread XX FF member of the steroid hormone receptor superfamily; FF may participate in regulation of lipid metabolism and cholesterol synthesis; FF loss of dimerization function leads to a loss of DNA-binding FF unless it is C-terminally truncated to AA 171; FF transcriptional repressor of apolipoprotein AI and CIII genes XX IN T00045; ARP-1; human, Homo sapiens. IN T01345; RXR-alpha; human, Homo sapiens. XX MX M00155; V$ARP1_01 XX BS R03989; ARP1$CONS_01; Quality: 2 BS R04403; AS$RXR_04; Quality: 2 BS R04405; AS$RXR_05; Quality: 2 BS R01465; AS$TR_01; Quality: 2 BS R04404; AS$TR_19; Quality: 2 BS R01193; CHICK$OA_02; Quality: 6; chick, Gallus gallus BS R00135; HS$APOA1_01; Quality: 6; human, Homo sapiens BS R02960; HS$APOA1_03; Quality: 2; human, Homo sapiens BS R01612; HS$APOB_01; Quality: 6; human, Homo sapiens BS R02657; HS$APOC3_01; Quality: 1; human, Homo sapiens BS R00912; RAT$INS2_04; Quality: 6; rat, Rattus norvegicus XX DR EMBL: M64497; HSARP1(r). DR SwissProt: P24468; ARP1_HUMAN. DR PIR: A37133; A37133. DR Compel: C00016 DR Compel: C00018 XX RN [1] RA Ladias J. A. A., Karathanasis S. K. RT Regulation of the apolipoprotein A1 gene by ARP-1, RT a novel member of the steroid receptor superfamily RL Science 251:561-565 (1991). RN [2] RA Tran P., Zhang X.-K., Salbert G., Hermann T., Lehmann J. M., Pfahl M. RT COUP orphan receptors are negative regulators of retinoic RT acid response pathways RL Mol. Cell. Biol. 12:4666-4676 (1992). RN [3] RA Widom R. L., Rhee M., Karathanasis S. K. RT Repression by ARP-1 sensitizes apolipoprotein AI gene RT responsiveness to RXRalpha and retinoic acid RL Mol. Cell. Biol. 12:3380-3389 (1992). XX // AC T00046 XX ID T00046 XX DT 15.10.92 (created); ewi. XX FA ASF-1 XX SY TGA1a; TGA1b; XX OS tobacco, Nicotiana tabacum OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC asteridae; solanes; solanaceae XX BS R00009; CAMV$35SR_01; Quality: 6; CaMV, cauliflower mosaic virus BS R01174; TDNA$NOS_01; Quality: 6; Agrobacterium tumefaciens BS R00679; WHEAT$H3_01; Quality: 6; wheat, Triticum aestivum XX RN [1] RA Lam E., Katagiri F., Chua N.-H. RT Plant nuclear factor ASF-1 binds to an essential region RT of the nopaline synthase promoter RL J. Biol. Chem. 265:9909-9913 (1990). XX // AC T00047 XX ID T00047 XX DT 15.10.92 (created); ewi. XX FA ASF-1 XX OS pea, Pisum sativum OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC rosidae; fabales; fabaceae XX RN [1] RA Lam E., Benfey P. N., Gilmartin P. M., Fang R.-X., Chua N.-H. RT Site-specific mutations alter in vitro factor binding RT and change promoter expression patterns in transgenic plants RL Proc. Natl. Acad. Sci. USA 86:7890-7894 (1989). XX // AC T00048 XX ID T00048 XX DT 10.11.92 (created); ewi. DT 03.09.96 (updated); ewi. XX FA ATBF1-B XX SY AT motif binding factor 1B; ATBF1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0021; CH+homeo; 3.1.4.1.1. XX SZ 2783 AA; 305.7 kDa (cDNA) XX SQ MRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSED SQ EWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAI SQ GNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCN SQ YSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIE SQ DVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTA SQ EEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDMLNNKIHLQLHLTHL SQ HSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGKQPETSEDLGKNILP SQ SASTEQSGDLKPSPADPGSVREDSGFICWKKGCNQVFKTSAALQTHFNEVHAKRPQLPVS SQ DRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHLETSHLE SQ LSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLEDKQSPTGSDSGSVQ SQ EDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLK SQ RALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASG SQ SSNGTGNSSSISLSSSTPSPVSTSGSNTFTTSNPSSAGIAPSSNLLSQVPTESVGMPPLG SQ NPIGANIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQQQQQQQAQTLAQAQAQVQA SQ HLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVS SQ LPVTSGALTLTGTGPGLLEDLKAQVQVPQQSHQQILPQQQQNQLSIAQSHSALLQPSQHP SQ EKKNKLVIKEKEKESQRERDSAEGGEGNTGPKETLPDALKAKEKKELAPGGGSEPSMLPP SQ RIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKTDQGENLEKLECDSCGKLFSN SQ ILILKSHQEHVHQNYFPFKQLERFAKQYRDHYDKLYPLRPQTPEPPPPPPPPPPPPLPAA SQ PPQPASTPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQL SQ PPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQ SQ IKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEPP SQ KQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNAR SQ QKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKD SQ EDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSAPAPSANNTASSAFLQLTAEAE SQ ELATFNSKTEAGDEKPKLAEAPSAQPNQTQEKQGQPKPELQQQEQPEQKTNTPQQKLPQL SQ VSLPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQ SQ CKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIP SQ QIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTITPEQLE SQ ILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCP SQ FCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLP SQ PSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDD SQ CSSVNTAITDTTTGDEGNADNDSATGIATETKSSSAPNEGLTKAAMMAMSEYEDRLSSGL SQ VSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGASGSAGKSGDSGDRPGQKRFRTQMT SQ NLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFGI SQ NQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQ SQ LMAQQELDRIKKANEVLGLAAQQQGMFDNTPLQALNLPTAYPALQGIPPVLLPGLNSPSL SQ PGFTPSNTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSSPTPAQATMAMGPQQ SQ PPQQQQQQQQPQVQQPPPPPAAQPPPTPQLPLQQQQQRKDKDSEKVKEKEKAHKGKGEPL SQ PVPKKEKGEAPTATAATISAPLPTMEYAVDPAQLQALQAALTSDPTALLTSQFLPYFVPG SQ FSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSQALMGLSPGSLLQQYQQYQQSLQEA SQ IQQQQQQKVQQQQPKASQTPVPPGAPSPDKDPAKESPKPEEQKNTPREVSPLLPKLPEEP SQ EAESKSADSLYDPFIVPKVQYKLVCRKCQAGFSDEEAARSHLKSLCFFGQSVVNLQEMVL SQ HVPTGGGGGGSGGGGGGGGGGGGGGGGSYHCLACESALCGEEALSQHLESALHKHRTITR SQ AARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPPSAAAPSSASPHASRKSWPQV SQ VSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDYSEESDTDLSQKSDGPASPVE SQ GPKDPSCPKDSGLTSVGTDTFRL XX SC translated from EMBL #D10250 XX FT 809 880 glutamine-rich region (36/72) FT 1117 1211 proline-rich region (37/95) FT 72 94 zinc finger 1 FT 128 150 zinc finger 2 FT 176 198 zinc finger 3 FT 311 332 zinc finger 4 FT 340 356 zinc finger 5 FT 448 471 zinc finger 6 FT 489 509 zinc finger 7 FT 517 538 zinc finger 8 FT 633 655 zinc finger 9 FT 684 706 zinc finger 10 FT 1071 1087 zinc finger 11 FT 1416 1437 zinc finger 12 FT 1618 1634 zinc finger 13 FT 1799 1820 zinc finger 14 FT 2112 2134 zinc finger 15 FT 2545 2633 zinc finger 16 FT 2611 2654 zinc finger 17 FT 1231 1290 homeo domain 1 FT 1328 1387 homeo domain 2 FT 1727 1786 homeo domain 3 FT 2032 2091 homeo domain 4 FT 216 260 acidic region (17/45) FT 569 606 acidic region (15/38) FT 719 773 serine-/threonine-rich region (28/55) FT 1440 1459 acidic region (11/20) FT 1522 1617 proline-/glutamine-rich region (47/96) FT 2267 2317 proline-/glutamine-rich region (37/51) FT 2448 2478 glutamine-rich region (18/31) FT 2585 2607 glycine-rich region (22/23) XX SF 17 zinc finger motifs and 4 homeo domains SF proline-rich region, glutamine-rich region, acidic SF region, serine/threonine-rich region SF a splice variant is ATBF1-A [1]; XX FF binds to the alpha-fetoprotein enhancer XX DR EMBL: D10250; HSAFPEBP(r). XX RN [1] RA Miura Y., Tam T., Ido A., Morinaga T., Miki T., Hashimoto T., Tamaoki T. RT Cloning and characterization of an ATBF1 isoform that RT expresses in a neuronal differentiation-dependent manner RL J. Biol. Chem. 270:26840-26848 (1995). RN [2] RA Morinaga T., Yasuda H., Hashimoto T., Higashio K., Tamaoki T. RT A human alpha-fetoprotein enhancer-binding protein, RT ATBF1, contains four homeodomains and seventeen zinc fingers RL Mol. Cell. Biol. 11:6041-6049 (1991). XX // AC T00049 XX ID T00049 XX DT 15.10.92 (created); ewi. DT 08.01.96 (updated); hiwi. XX FA ATF XX SY yATF; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 1.1.1.6.6. XX SZ 66 kDa XX SF phosphorylation XX BS R00362; AD$E4_16; Quality: 4; adenovirus type 5 BS R00592; HS$GHA_02; Quality: 4; human, Homo sapiens BS R01492; RAT$TH_02; Quality: 4; rat, Rattus norvegicus BS R03846; Y$LPD1_02; Quality: 4; yeast, Saccharomyces cerevisiae XX RN [1] RA Lin Y.-S., Green M. R. RT Interaction of a common cellular transcription factor, RT ATF, with regulatory elements in both E1a- and cyclic RT AMP-inducible promoters RL Proc. Natl. Acad. Sci. USA 85:3396-3400 (1988). RN [2] RA Lin Y.-S., Green M. R. RT Identification and purification of a Saccharomyces RT cerevisiae protein with the DNA binding specificity RT of mammalian activating transcription factor RL J. Biol. Chem. 264:109-113 (1989). RN [3] RA Jones R. H., Jones N. C. RT Mammalian cAMP-responsive element can activate transcription RT in yeast and binds a yeast factor(s) that resembles RT the mammalian transcription factor ATF RL Proc. Natl. Acad. Sci. USA 86:2176-2180 (1989). XX // AC T00050 XX ID T00050 XX DT 15.10.92 (created); ewi. DT 08.01.96 (updated); hiwi. XX FA ATF XX OS fission yeast, Schizosaccharomyces pombe OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 1.1.1.6.6. XX SF phosphorylation XX BS R00362; AD$E4_16; Quality: 4; adenovirus type 5 XX RN [1] RA Jones R. H., Jones N. C. RT Mammalian cAMP-responsive element can activate transcription RT in yeast and binds a yeast factor(s) that resembles RT the mammalian transcription factor ATF RL Proc. Natl. Acad. Sci. USA 86:2176-2180 (1989). XX // AC T00051 XX ID T00051 XX DT 15.10.92 (created); ewi. DT 30.11.94 (updated); ewi. XX FA ATF XX SY ATF-1; ATF-2; ATF-3; ATF-4; ATF-5; ATF-6; ATF-7; ATF-8; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO CREB, EIIA-EF, EPF, EIIaE-B, 47-kDa-protein XX CL C0008; bZIP; . XX SZ 45 kDa XX IN T00108; C/EBPalpha; rat, Rattus norvegicus. IN T00122; c-Fos; mouse, Mus musculus. IN T00123; c-Fos; human, Homo sapiens. IN T00124; c-Fos; rat, Rattus norvegicus. IN T00125; c-Fos; chick, Gallus gallus. IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T00163; CREB; human, Homo sapiens. IN T00164; CREB; rat, Rattus norvegicus. IN T00166; deltaCREB; human, Homo sapiens. IN T00167; CRE-BP1; human, Homo sapiens. IN T00171; C/EBPepsilon; rat, Rattus norvegicus. IN T00209; E1A 13S protein; adenovirus type 2. IN T00216; C/EBPgamma; mouse, Mus musculus. IN T00292; FraI; mouse, Mus musculus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. IN T01208; FraI; rat, Rattus norvegicus. IN T01313; ATF-3; human, Homo sapiens. XX BS R01990; AD$E1A_14; Quality: 5; adenovirus type 5 BS R01992; AD$E1A_16; Quality: 5; adenovirus type 5 BS R01997; AD$E1A_21; Quality: 5; adenovirus type 5 BS R00322; AD$E2AE1_07; Quality: 4; adenovirus type 2 BS R00343; AD$E3_05; Quality: 2; adenovirus type 2 BS R00350; AD$E4_04; Quality: 2; adenovirus BS R00352; AD$E4_06; Quality: 2; adenovirus BS R00359; AD$E4_13; Quality: 2; adenovirus type 5 BS R00360; AD$E4_14; Quality: 2; adenovirus type 5 BS R00362; AD$E4_16; Quality: 4; adenovirus type 5 BS R02403; AD$E4_23; Quality: 2; adenovirus BS R03430; AD$E4_25; Quality: 2; adenovirus type 2 BS R03431; AS$ATF_01; Quality: 6 BS R03432; AS$ATF_02; Quality: 6 BS R03433; AS$ATF_03; Quality: 6 BS R02126; ATF$CONS; Quality: 1 BS R00807; HCMV$IE1_21; Quality: 4; hCMV, human cytomegalovirus BS R02812; HS$7SL_01; Quality: 2; human, Homo sapiens BS R00468; HS$CFOS_11; Quality: 2; human, Homo sapiens BS R00592; HS$GHA_02; Quality: 4; human, Homo sapiens BS R01562; HS$VIP_04; Quality: 4; human, Homo sapiens BS R01053; MOUSE$M1H2KB_01; Quality: 5; mouse, Mus musculus BS R01062; MOUSE$M1H2KB_10; Quality: 5; mouse, Mus musculus BS R03001; MOUSE$SURF2_01; Quality: 4; mouse, Mus musculus BS R02658; RAT$CYCS_01; Quality: 4; rat, Rattus norvegicus BS R01492; RAT$TH_02; Quality: 4; rat, Rattus norvegicus XX RN [1] RA Lin Y.-S., Green M. R. RT Interaction of a common cellular transcription factor, RT ATF, with regulatory elements in both E1a- and cyclic RT AMP-inducible promoters RL Proc. Natl. Acad. Sci. USA 85:3396-3400 (1988). RN [2] RA Loeken M. R., Brady J. RT The Adenovirus EIIA Enhancer RL J. Biol. Chem. 264:6572-6579 (1989). RN [3] RA Horikoshi M., Hai T., Lin Y.-S., Green M. R., Roeder R. G. RT Transcription factor ATF interacts with the TATA factor RT to facilitate establishment of a preinitiation complex RL Cell 54:1033-1042 (1989). RN [4] RA Jones R. H., Jones N. C. RT Mammalian cAMP-responsive element can activate transcription RT in yeast and binds a yeast factor(s) that resembles RT the mammalian transcription factor ATF RL Proc. Natl. Acad. Sci. USA 86:2176-2180 (1989). RN [5] RA Shaw P. E., Frasch S., Nordheim A. RT Repression of c-fos transcription is mediated through p6SRF bound to the SRE RL EMBO J. 8:2567-2574 (1989). RN [6] RA Hai T., Liu F., Coukos W. J., Green M. R. RT Transcription factor ATF cDNA clones: an extensive RT family of leucine zipper proteins able to selectively RT form DNA-binding heterodimers RL Genes Dev. 3:2083-2090 (1989). XX // AC T00052 XX ID T00052 XX DT 15.10.92 (created); ewi. DT 07.05.97 (updated); ewi. XX FA ATF-a XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0008; bZIP; 1.1.1.6.5.1. XX SZ 483 AA; 51.8 (cDNA) XX SQ MGDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKN SQ CEEVGLFNELASSFEHEFKKAADEDEKKAAAGPLDMSLPSTPDIKIKEEEPVEVDSSPPD SQ SPASSPCSPPLKEKEVTPKPVLISTPTPTIVRPGSLPLHLGYDPLHPTLPSPTSVITQAP SQ PSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQMPSVISLARPVSMVPNIPGIPGPPVN SQ SSGSISPSGHPIPSEAKMRLKATLTHQVSSINGGCGMVVGTASTMVTARPEQSQILIQHP SQ DAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNRAAASRCRQKRKLWVSSL SQ EKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAHKDCPVTALQKKTQGYLESPKESSEP SQ TGSPAPVIQHSSATAPSNGLSVRSAAEAVATSVLTQMASQRTELSMPIQSHVIMTPQSQS SQ AGR XX SC SwissProt #P17544 XX FT 114 134 missing in ATF-adelta FT 137 137 potential PKC phosphorylation site FT 182 182 potential PKC phosphorylation site FT 287 287 potential PKC phosphorylation site FT 326 326 potential PKC phosphorylation site FT 334 354 basic region FT 360 388 leucine zipper (L5) XX SF interacting with both NF-kappaB subunits [2]; SF with NF-kappaB, ATF-a forms the NF-ELAM1 complex found SF to bind to the E-selectin promoter [2]; XX CP (HeLa) XX IN T00593; NF-kappaB1; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. XX BS R00322; AD$E2AE1_07; Quality: 4; adenovirus type 2 BS R02126; ATF$CONS; Quality: 6 XX DR EMBL: X52943; HSATFA(r). DR SwissProt: P17544; ATFA_HUMAN. DR PIR: S12741; S12741. DR Compel: C00093 DR Compel: C00097 DR Compel: C00102 DR Compel: C00103 XX RN [1] RA Gaire M., Chatton B., Kedinger C. RT Isolation and characterization of two novel, closely RT related ATF cDNA clones from HeLa cells RL Nucleic Acids Res. 18:3467-3473 (1990). RN [2] RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., RA DeRaemy-Schenk A.-M., Chen B. P. C., Hai T., DeLamarter J. F., Whelan J. RT Cyclic AMP-independent ATF family members interact RT with NF-kappaB and function in the activation of the RT E-selectin promoter in response to cytokines RL Mol. Cell. Biol. 13:7180-7190 (1993). XX // AC T00053 XX ID T00053 XX DT 15.10.92 (created); ewi. DT 22.08.96 (updated); ewi. XX FA ATF-adelta XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0008; bZIP; 1.1.1.6.5.2. XX SZ 462 AA; 49.6 kDa (cDNA) XX SQ MGDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKN SQ CEEVGLFNELASSFEHEFKKAADEDEKKAAAGPLDMSLPSTPDIKIKEEEPVEEVTPKPV SQ LISTPTPTIVRPGSLPLHLGYDPLHPTLPSPTSVITQAPPSNRQMGSPTGSLPLVMHLAN SQ GQTMPVLPGPPVQMPSVISLARPVSMVPNIPGIPGPPVNSSGSISPSGHPIPSEAKMRLK SQ ATLTHQVSSINGGCGMVVGTASTMVTARPEQSQILIQHPDAPSPAQPQVSPAQPTPSTGG SQ RRRRTVDEDPDERRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLL SQ RNEVAQLKQLLLAHKDCPVTALQKKTQGYLESPKESSEPTGSPAPVIQHSSATAPSNGLS SQ VRSAAEAVATSVLTQMASQRTELSMPIQSHVIMTPQSQSAGR XX SC SwissProt #P17544 and edited XX FT 313 333 basic region FT 339 367 leucine zipper (L5) XX CP (HeLa) XX BS R02126; ATF$CONS; Quality: 6 XX DR EMBL: X52943; HSATFA(r). DR SwissProt: P17544; ATFA_HUMAN. DR PIR: S12741; S12741. XX RN [1] RA Gaire M., Chatton B., Kedinger C. RT Isolation and characterization of two novel, closely RT related ATF cDNA clones from HeLa cells RL Nucleic Acids Res. 18:3467-3473 (1990). RN [2] RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., RA DeRaemy-Schenk A.-M., Chen B. P. C., Hai T., DeLamarter J. F., Whelan J. RT Cyclic AMP-independent ATF family members interact RT with NF-kappaB and function in the activation of the RT E-selectin promoter in response to cytokines RL Mol. Cell. Biol. 13:7180-7190 (1993). XX // AC T00054 XX ID T00054 XX DT 15.10.92 (created); ewi. XX FA ATF-like XX OS clawed frog, Xenopus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX SZ 75 kDa, 77 kDa XX CP (oocytes) XX BS R00343; AD$E3_05; Quality: 4; adenovirus type 2 BS R02126; ATF$CONS; Quality: 6 BS R02958; XENLA$H2B_01; Quality: 4; clawed frog, Xenopus laevis XX RN [1] RA Richter J. D. RT In vivo photocrosslinking reveals that transcription RT factor binding to the mammalian ATF recognition sequence RT is required for E1A-induced transactivation in injected RT Xenopus laevis oocytes RL Nucleic Acids Res. 17:4503-4516 (1989). XX // AC T00055 XX ID T00055 XX DT 15.04.93 (created); ewi. XX FA B'' XX SY TFIIIB-p90; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 90 kDa (SDS) XX FF pol III transcription factor; FF constituent of yeast TFIIIB XX IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX RN [1] RA Kassavetis G. A., Joazeiro C. A. P., Pisano M., Geiduschek RA E. P., Colbert T., Hahn S., Blanco J. A. RT The role of the TATA-binding protein in the assembly RT and function of the multisubunit yeast RNA polymerase RT III transcription factor, TFIIIB RL Cell 71:1055-1064 (1992). XX // AC T00056 XX ID T00056 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA BAF1 XX SY ABF1; ABFI; ARS binding factor 1; ARS1; EBF2; OBF1; SBF-B; bidirectionally SY activating factor; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 2.5.1.0.1. XX SZ 731 AA; 82 kDa (gene), 120 kDa, 135 kDa (SDS) XX SQ MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNK SQ HFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDN SQ NNGSNNKASNDSKLDFVTDDLEYHLANIHPDDTNDKVESRSNEVNGNNDDDADANNIFKQ SQ QGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVND SQ EDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNTNNNDHNNNSNINNNNVGSHGI SQ SSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKIL SQ QNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIAR SQ RITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAG SQ TSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQ SQ ITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGH SQ NNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKE SQ VENLHQNNDDDVDDVMVDVDVESQYNKNTNHHNNHHSQPHHDEEDVAGLIGKADDEEDLS SQ DENIQPELRGQ XX SC SwissProt #P14164 XX FT 9 91 atypical zinc finger region FT 3 439 homologous region with K.lactis ABF1 XX MX M00015; F$ABF1_01 MX M00197; F$ABF_C XX BS R02377; ABF1$CONS; Quality: 6 BS R03476; AS$ABF1_01; Quality: 6 BS R01923; BAF1$CONS; Quality: 6 BS R02925; Y$ARS120_01; Quality: 6; yeast, Saccharomyces cerevisiae BS R01921; Y$ARS1_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01951; Y$ARS1_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R01922; Y$BAF1_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R03820; Y$CHA1_04; Quality: 5; yeast, Saccharomyces cerevisiae BS R02798; Y$ENO2_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R00716; Y$HMR_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R03847; Y$LPD1_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R03848; Y$LPD1_04; Quality: 2; yeast, Saccharomyces cerevisiae BS R01198; Y$PGK_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R02417; Y$PYK1_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R02375; Y$RPC160_01; Quality: 3; yeast, Saccharomyces cerevisiae BS R02376; Y$RPC40_01; Quality: 3; yeast, Saccharomyces cerevisiae BS R01691; Y$RPL2A_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01692; Y$RPL2B_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01920; Y$YPT1_01; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: S93804; S93804(g). DR EMBL: M29067; SCABF1A(g). DR EMBL: X16385; SCBAF1(g). DR EMBL: M63578; SCOBF1(g). DR SwissProt: P14164; BAF1_YEAST. DR PIR: A34217; A34217. DR PIR: A39354; A39354. DR PIR: A40081; A40081. DR PIR: S25408; S25408. DR PIR: S29870; S29870. XX RN [1] RA Goncalves P. M., Maurer K., Mager W. H., Planta R. J. RT Kluyveromyces contains a functional ABF1-homologue RL Nucleic Acids Res. 20:2211-2215 (1992). RN [2] RA Della Seta F., Ciafre S.-A., Marck C., Santoro B., RA Presutti C., Sentenac A., Bozzoni I. RT The ABF1 Factor Is the Transcriptional Activator of RT the L2 Ribosomal Protein Genes in Saccharomyces cerevisiae RL Mol. Cell. Biol. 10:2437-2441 (1990). RN [3] RA Halfter H., Kavety B., Vandekerckhove J., Kiefer F., Gallwitz D. RT Sequence, expression and mutational analysis of BAF1, RT a transcriptional activator and ARS1-binding protein RT of the yeast Saccharomyces cerevisiae RL EMBO J. 8:4265-4272 (1989). RN [4] RA Rode P. R., Sweder K. S., Oegema K. F., Campbell J. L. RT The gene encoding ARS-binding factor I is essential RT for the viability of yeast RL Genes Dev. 3:1926-1939 (1989). RN [5] RA Halfter H., Mueller U., Winnacker E.-L., Gallwitz D. RT Isolation and DNA-binding characteristics of a protein RT involved in transcription activation of two divergently RT transcribed, essential yeast genes RL EMBO J. 8:3029-3037 (1989). RN [6] RA Holland J. P., Brindle P. K., Holland M. J. RT Sequences within an upstream activation site in the RT yeast enolase gene ENO2 modulate Repression of ENO2 RT Expression in strains carrying a null mutation in RT the positive regulatory gene GCR1 RL Mol. Cell. Biol. 10:4863-4871 (1990). RN [7] RA Brindle P. K., Holland J. P., Willett C. E., Innis M. A., Holland M. J. RT Multiple factors bind the upstream activation sites RT of the yeast enolase genes ENO1 and ENO2: ABFI protein, RT like repressor activator protein RAP1, binds cis-acting RT sequences which modulate repression or activation of transcription RL Mol. Cell. Biol. 10:4872-4885 (1990). RN [8] RA Shore D., Stillman D. J., Brand A. H., Nasmyth K. A. RT Identification of silencer binding proteins from yeast: RT possible roles in SIR control and DNA replication RL EMBO J. 6:461-467 (1987). RN [9] RA Buchman A. R., Kimmerley W. J., Rine J., Kornberg R. D. RT Two DNA-Binding Factors Recognize Specific Sequences RT at Silencers, Upstream Activating Sequences, Autonomously RT Replicating Sequences, and Telomeres in Saccharomyces cerevisiae RL Mol. Cell. Biol. 8:210-225 (1988). RN [10] RA Kimmerly W., Buchman A., Kornberg R., Rine J. RT Roles of two DNA-binding factors in replication, segregation RT and transcriptional repression mediated by a yeast silencer RL EMBO J. 7:2241-2253 (1988). RN [11] RA Diffley J. F. X., Stillman B. RT Purification of a yeast protein that binds to origins RT of DNA replication and a transcriptional silencer RL Proc. Natl. Acad. Sci. USA 85:2120-2124 (1988). RN [12] RA Della Seta F., Treich I., Buhler J.-M., Sentenac A. RT ABF1 binding sites in yeast RNA polymerase genes RL J. Biol. Chem. 265:15168-15175 (1990). XX // AC T00057 XX ID T00057 XX DT 15.10.92 (created); ewi. XX FA band I factor XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (neonatal) XX FF different from SRF XX BS R00475; MOUSE$CFOS_04; Quality: 6; mouse, Mus musculus XX RN [1] RA Levi B.-Z., Kasik J. W., Burke P. A., Prywes R., Roeder RA R. G., Appella E., Ozato K. RT Neonatal induction of a nuclear protein that binds to the c-fos enhancer RL Proc. Natl. Acad. Sci. USA 86:2262-2266 (1989). XX // AC T00058 XX ID T00058 XX DT 25.01.93 (created); ewi. DT 08.01.96 (updated); hiwi. XX FA BAP XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 58 kDa (SDS) XX SF phosphorylation XX CP (liver) XX FF phosphorylation required for DNA binding XX BS R01589; XENLA$VITB1_03; Quality: 6; clawed frog, Xenopus laevis XX RN [1] RA Kugler W., Kaling M., Ross K., Wagner U., Ryffel G. U. RT BAP, a rat liver protein that activates transcription RT through a promoter element with similarity to the USF/MLTF binding site RL Nucleic Acids Res. 18:6943- (1990). XX // AC T00059 XX ID T00059 XX DT 12.03.93 (created); ewi. DT 14.05.94 (updated); hwi; ewi. XX FA BCFI XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; OC lepidoptera; bombycoidea; bombycidae XX HO GATA-1 XX CP (follicular cells) XX FF BCFI-binding to DNA is a prerequisite for BCFII-binding; FF synergistic action of BCFI and BCFII XX BS R03050; BOMMO$CHOR_02; Quality: 6; silk moth, Bombyx mori XX DR EMBL: M64609; BMBCF(g). XX RN [1] RA Skeiky Y. A. W., Iatrou K. RT Synergistic interactions of silkmoth chorion promoter-binding factors RL Mol. Cell. Biol. 11:1954-1964 (1991). XX // AC T00060 XX ID T00060 XX DT 12.03.93 (created); ewi. DT 17.02.94 (updated); hwi. XX FA BCFII XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; OC lepidoptera; bombycoidea; bombycidae XX CP (follicular cells) XX FF BCFI-binding to DNA is a prerequisite for BCFII-binding; FF synergistic action of BCFI and BCFII XX BS R03049; BOMMO$CHOR_01; Quality: 6; silk moth, Bombyx mori XX DR EMBL: M64609; BMBCF(g). XX RN [1] RA Skeiky Y. A. W., Iatrou K. RT Synergistic interactions of silkmoth chorion promoter-binding factors RL Mol. Cell. Biol. 11:1954-1964 (1991). XX // AC T00061 XX ID T00061 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA B factor XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX HO TFIID XX BS R00047; DROME$AC5C_01; Quality: 6; fruit fly, Drosophila melanogaster BS R00674; DROME$H3_01; Quality: 6; fruit fly, Drosophila melanogaster BS R00689; DROME$HH4_10; Quality: 6; fruit fly, Drosophila melanogaster BS R00759; DROME$HSP70_09; Quality: 6; fruit fly, Drosophila melanogaster XX RN [1] RA Parker C. S., Topol J. RT A Drosophila RNA polymerase II transcription factor RT contains a promoter-region-specific DNA-binding activity RL Cell 36:357-369 (1984). XX // AC T00062 XX ID T00062 XX DT 15.10.92 (created); ewi. DT 25.01.93 (updated); hse. XX FA BGP1 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX SZ 66 kDa (SDS) XX CP (erythrocytes) XX BS R02054; AS$BGP1_01; Quality: 2 BS R02055; AS$BGP1_02; Quality: 2 BS R02127; BGP1$CONS; Quality: 6 BS R00527; CHICK$BAG_01; Quality: 2; chick, Gallus gallus XX RN [1] RA D Lewis C., Clark S. P., Felsenfeld G., Gould H. RT An erythrocyte-specific protein that binds to the RT poly(dG) region of the chicken beta-globin gene promoter RL Genes Dev. 2:863-873 (1988). RN [2] RA Clark S. P., Lewis C. D., Felsenfeld G. RT Properties of BGP1, a poly(dG)-binding protein from chicken erythrocytes RL Nucleic Acids Res. 18:5119 (1990). XX // AC T00063 XX ID T00063 XX DT 03.11.92 (created); ewi. DT 06.12.96 (updated); ewi. XX FA Bcd XX SY Bicoid; PRD-4; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0006; homeo; 3.1.1.16.1. XX SZ 494 AA; 54.5 kDa (gene) XX SQ MAQPPPDQNFYHHPLPHTHTHPHPHSHPHPHSHPHPHHQHPQLQLPPQFRNPFDLLFDER SQ TGAINYNYIRPYLPNQMPKPDVFPSEELPDSLVMRRPRRTRTTFTSSQIAELEQHFLQGR SQ YLTAPRLADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHKDQSYEGMPLSPGMKQSDGDP SQ PSLQTLSLGGGATPNALTPSPTPSTPTAHMTEHYSESFNAYYNYNGGHNHAQANRHMHMQ SQ YPSGGGPGPGSTNVNGGQFFQQQQVHNHQQQLHHQGNHVPHQMQQQQQQAQQQQYHHFDF SQ QQKQASACRVLVKDEPEADYNFNSSYYMRSGMSGATASASAVARGAASPGSEVYEPLTPK SQ NDESPSLCGIGIGGPCAIAVGETEAADDMDDGTSKKTTLQILEPLKGLDKSCDDGSSDDM SQ STGIRALAGTGNRGAAFAKFGKPSPPQGPQPPLGMGGVALGESNQYQCTMDTIMQAYNPH SQ RNAAGNSQFAYCFN XX SC SwissProt #P09081 XX FT 12 40 histidine-rich region (15/29) FT 97 156 homeo domain FT 258 294 glutamine-rich region (20/37) XX SF homeo domain fo Paired-type SF Lys-146 within the recognition helix (helix 3 of homeo SF domain) discriminates DNA-binding between Bcd and Antp [10]; SF Bcd may contain a RNA-binding domain as well [13]; SF mutant K146K alters DNA-binding specificity , but SF also extinguishes pattern formation capability and SF cad translation repression by Bcd [8]; XX FF concentration-dependent activator of eve stripe 2 FF element and of hairy in stripe 1; FF maternal effect gene product [18]; FF major determinant of antero-posterior axis of the FF embryo [4] in regulating the gap genes hunchback [18], FF [10] and Krueppel [14]; FF synergizes with Hunchback [12]; FF interaction of the Bcd homeo domain with mRNA (e. FF g., a 120 Nt region of cad) represses translation [7], [8]; FF bcd mRNA is synthesized by nurse cells and is passed FF to the anterior pole of the developing oocyte [1], [2]; FF it is under translational control, the protein diffuses FF along the egg axis [6]; FF transcriptional activation by Bcd is later on repressed FF at the anterior pole in response to the torso/D-raf FF pathway causing phosphorylation of the Bcd activation domain [11]; XX MX M00140; I$BCD_01 XX BS R02487; DROME$EVE_16; Quality: 6; fruit fly, Drosophila melanogaster BS R02489; DROME$EVE_18; Quality: 6; fruit fly, Drosophila melanogaster BS R02492; DROME$EVE_21; Quality: 6; fruit fly, Drosophila melanogaster BS R02494; DROME$EVE_23; Quality: 6; fruit fly, Drosophila melanogaster BS R02498; DROME$EVE_27; Quality: 6; fruit fly, Drosophila melanogaster BS R02484; DROME$HB_01; Quality: 2; fruit fly, Drosophila melanogaster BS R02275; DROME$KR_08; Quality: 6; fruit fly, Drosophila melanogaster BS R02278; DROME$KR_11; Quality: 6; fruit fly, Drosophila melanogaster BS R02280; DROME$KR_13; Quality: 6; fruit fly, Drosophila melanogaster BS R02284; DROME$KR_17; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: X07870; DMBCDG(g). DR EMBL: K03517; DMBCDHB(r). DR SwissProt: P09081; HMBC_DROME. DR PIR: S00835; WJFFBC. DR Flybase: FBgn0000166; bcd. XX RN [1] RA Frigerio G., Burri M., Bopp D., Baumgartner S., Noll M. RT Structure of the segmentation gene paired and the RT Drosophila PRD gene set as part of a gene network RL Cell 47:735-746 (1986). RN [2] RA Berleth T., Burri M., Thoma G., Bopp D., Richstein RA S., Frigerio G., Noll M., Nuess-lein-Volhard C. RT The role of localization of bicoid RNA in organizing RT the anterior pattern of the Drosophila embryo RL EMBO J. 7:1749-1756 (1988). RN [3] RA Macdonald P. M., Struhl G. RT Cis-acting sequences responsible for anterior localization RT of bicoid mRNA in Drosophila embryos RL Nature 336:595-599 (1988). RN [4] RA Fronhoefer H. G., Nuesslein-Volhard C. RT Organization of anterior pattern in the Drosophila RT embryo by the maternal gene bicoid RL Nature 324:120-125 (1986). RN [5] RA Hanes S. D., Riddihough G., Ish-Horowicz D., Brent R. RT Specific DNA recognition and intersite spacing are RT critical for action of the bicoid morphogen RL Mol. Cell. Biol. 14:3364-3375 (1994). RN [6] RA Driever W., Nuesslein-Volhard C. RT A gradient of bicoid protein in Drosophila embryos RL Cell 54:83-93 (1988). RN [7] RA Riviera-Pomar R., Niessing D., Schmidt-Ott U., Gehring W. J., Jaeckle H. RT RNA binding and translational suppression by bicoid RL Nature 379:746-749 (1996). RN [8] RA Dubnau J., Struhl G. RT RNA recognition and translational regulation by a homeodomain protein RL Nature 379:694-699 (1996). RN [9] RA Ingham P. W. RT The molecular genetics of embryonic pattern formation in Drosophila RL Nature 335:25-34 (1988). RN [10] RA Hanes S. D., Brent R. RT DNA specificity of the Bicoid activator protein is RT determined by homeodomain recognition helix residue 9 RL Cell 57:1275-1283 (1989). RN [11] RA Ronchi E., Treisman J., Dostatni N., Struhl G., Desplan C. RT Down-regulation of the Drosophila morphogen Bicoid RT by the Torso receptor-mediated signal transduction cascade RL Cell 74:347-355 (1993). RN [12] RA Simpson-Brose M., Treisman J., Desplan C. RT Synergy between the Hunchback and Bicoid morphogens RT is required for anterior patterning in Drosophila RL Cell 78:855-865 (1994). RN [13] RA Rebagliati M. RT An RNA recognition motif in the bicoid protein RL Cell 58:213-232 (1989). RN [14] RA Hoch M., Seifert E., Jaeckle H. RT Gene expression mediated by cis-acting sequences of RT the Krueppel gene in response to the Drosophila morphogens RT bicoid and hunchback RL EMBO J. 10:2267-2278 (1991). RN [15] RA Small S., Kraut R., Hoey T., Warrior R., Levine M. RT Transcriptional regulation of a pair-rule stripe in Drosophila RL Genes Dev. 5:827-839 (1991). RN [16] RA Stanojevic D., Small S., Levine M. RT Regulation of segmentation stripe by overlapping activators RT and repressors in the Drosophila embryo RL Science 254:1385-1387 (1991). RN [17] RA Riddihough G., Ish-Horowicz D. RT Individual stripe regulatory elements in the Drosophila RT hairy promoter respond to maternal, gap, and pair-rule genes RL Genes Dev. 5:840-854 (1991). RN [18] RA Struhl G., Struhl K., Macdonald P. M. RT The gradient morphogen bicoid is a concentration-dependent RT transcriptional activator RL Cell 57:1259-1273 (1989). XX // AC T00064 XX ID T00064 XX DT 21.01.93 (created); ewi. DT 26.10.94 (updated); ewi. XX FA BmFTZ-F1 XX SY FTZ-F1 (Drosophila); XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; OC lepidoptera; bombycoidea; bombycidae XX SZ 73 kDa (SDS) XX CP (posterior silk gland, 2nd day of 5th instar larvae) XX BS R00485; DROME$FTZ_05; Quality: 5; fruit fly, Drosophila melanogaster XX RN [1] RA Ueda H., Sun G.-C., Murata T., Hirose S. RT A novel DNA-binding motif abuts the zinc-finger domain RT of insect nuclear hormone receptor FTZ-F1 and mouse RT embryonal long terminal repeat-binding protein RL Mol. Cell. Biol. 12:5667-5672 (1992). RN [2] RA Ueda H., Hirose S. RT Defining the sequence recognized with BmFTZ-F1, a RT sequence specific DNA binding factor in the silkworm, RT Bombyx mori, as revealed by direct sequencing of bound RT oligonucleotides and gel mobility shift competition analysis RL Nucleic Acids Res. 19:3689-3693 (1991). RN [3] RA Ueda H., Hirose S. RT Identification and purification of a Bombyx mori homologue of FTZ-F1 RL Nucleic Acids Res. 18:7229 (1990). XX // AC T00065 XX ID T00065 XX DT 14.12.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA B-Myb XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0022; trp; 3.5.1.1.3. XX SZ 700 AA; 78.8 kDa (cDNA), 110 kDa (SDS) [2]; XX SQ MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASH SQ FPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQ SQ CRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTI SQ KRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEEN SQ SEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVVEAANLL SQ IPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSAEDSINNSLVQLQASHQQQVLPPRQ SQ PSALVPSVTEYRLDGHTISDLSRSSRGELIPISPSTEVGGSGIGTPPSVLKRQRKRRVAL SQ SPVTENSTSLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCS SQ QKVVVTTPLHRDKTPLHQKHAAFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPH SQ LEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDVKLMMS SQ TLPKSLSLPTTAPSNSSSLTLSGIKEDNSLLNQGFLQAKPEKAAVAQKPRSHFTTPAPMS SQ SAWKTVACGGTRDQLFMQEKARQLLGRLKPSHTSRTLILS XX SC SwissProt #P10244 XX FT 25 77 basic DNA-binding repeat 1 FT 34 73 tryptophan cluster (W-X19-W-X18-W) FT 78 129 basic DNA-binding repeat 2 FT 86 125 tryptophan cluster (W-X19-W-X18-W) FT 130 180 basic DNA-binding repeat 3 FT 138 176 tryptophan cluster (W-X18-W-X18-W) XX CP widespread occurrence [2]; XX FF transcriptional activator (e. g., of cyclin D1 and FF cdc2 gene) and repressor, the latter by inhibiting FF transactivation by other Myb-proteins [2]; FF activation of cell cycle genes in fibroblasts reduces FF growth factor requirement and induces a transformed phenotype [3]; XX DR EMBL: X13293; HSBMYB(r). DR SwissProt: P10244; MYBB_HUMAN. DR PIR: S01991; S01991. XX RN [1] RA Nomura N., Takahashi M., Matsui M., Ishii S., Date RA T., Sasamoto S., Ishizaki R. RT Isolation of human cDNA clones of myb-related genes A-myb and B-myb RL Nucleic Acids Res. 16:11075-11090 (1988). RN [2] RA Foos G., Grimm S., Klempnauer K. H. RT Functional antagonism between members of the myb family: RT b-myb inhibits V-myb induced gene activation RL EMBO J. 11:4619-4629 (1992). RN [3] RA Sala A., Calabretta B. RT Regulation of BALB/c 3T3 fibroblast proliferation RT by B-myb is accompanied by selective activation of RT cdc2 and cyclin D1 expression RL Proc. Natl. Acad. Sci. USA 89:10415-10419 (1992). RN [4] RA Mizuguchi G., Nakagoshi H., Nagase T., Nomura N., Date T., Ueno Y., Ishii S. RT DNA Binding Activity and Transcriptional Activator RT Function of the Human B-myb Protein Compared with c-MYB RL J. Biol. Chem. 265:9280-9284 (1990). XX // AC T00066 XX ID T00066 XX DT 15.10.92 (created); ewi. XX FA BP1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF transcriptional repressor XX BS R01903; HS$BG_08; Quality: 6; human, Homo sapiens BS R01904; HS$BG_09; Quality: 6; human, Homo sapiens XX RN [1] RA Berg P. E., Williams D. M., Qian R.-L., Cohen R. B., RA Cao S.-X., Mittelman M., Schechter A. N. RT A common protein binds to two silencers 5' to the human beta-globin gene RL Nucleic Acids Res. 17:8833-8852 (1989). XX // AC T00067 XX ID T00067 XX DT 15.10.92 (created); ewi. XX FA BP2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01904; HS$BG_09; Quality: 6; human, Homo sapiens XX RN [1] RA Berg P. E., Williams D. M., Qian R.-L., Cohen R. B., RA Cao S.-X., Mittelman M., Schechter A. N. RT A common protein binds to two silencers 5' to the human beta-globin gene RL Nucleic Acids Res. 17:8833-8852 (1989). XX // AC T00068 XX ID T00068 XX DT 14.04.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA BRF1 XX SY BRF; TAF-70; TFIIIB-p70; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 596 AA; 70 kDa (SDS) XX SQ MPVCKNCHGTEFERDLSNANNDLVCKACGVVSEDNPIVSEVTFGETSAGAAVVQGSFIGA SQ GQSHAAFGGSSALESREATLNNARRKLRAVSYALHIPEYITDAAFQWYKLALANNFVQGR SQ RSQNVIASCLYVACRKEKTHHMLIDFSSRLQVSVYSIGATFLKMVKKLHITELPLADPSL SQ FIQHFAEKLDLADKKIKVVKDAVKLAQRMSKDWMFEGRRPAGIAGACILLACRMNNLRRT SQ HTEIVAVSHVAEETLQQRLNEFKNTKAAKLSVQKFRENDVEDGEARPPSFVKNRKKERKI SQ KDSLDKEEMFQTSEEALNKNPILTQVLGEQELSSKEVLFYLKQFSERRARVVERIKATNG SQ IDGENIYHEGSENETRKRKLSEVSIQNEHVEGEDKETEGTEEKVKKVKTKTSEEKKENES SQ GHFQDAIDGYSLETDPYCPRNLHLLPTTDTYLSKVSDDPDNLEDVDDEELNAHLLNEEAS SQ KLKERIWIGLNADFLLEQESKRLKQEADIATGNTSVKKKRTRRRNNTRSDEPTKTVDAAA SQ AIGLMSDLQDKSGLHAALKAAEESGDFTTADSVKNMLQKASFSKKINYDAIDGLFR XX SC SwissProt #P29056 XX SF N-terminus homologous to TFIIB XX FF pol III transcription factor XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX DR EMBL: M91073; SCTFIIBRF(g). DR EMBL: L00630; SCTFIIIB(g). DR SwissProt: P29056; TF3B_YEAST. DR PIR: A44072; A44072. DR PIR: A44296; A44296. DR PIR: S27464; S27464. XX RN [1] RA Poon D., Weil P. A. RT Immunopurification of yeast TATA-binding protein and associated factors RL J. Biol. Chem. 268:15325-15328 (1993). RN [2] RA Colbert T., Hahn S. RT A yeast TFIIB-related factor involved in RNA polymerase III transcription RL Genes Dev. 6:1940-1949 (1992). RN [3] RA Kassavetis G. A., Joazeiro C. A. P., Pisano M., Geiduschek RA E. P., Colbert T., Hahn S., Blanco J. A. RT The role of the TATA-binding protein in the assembly RT and function of the multisubunit yeast RNA polymerase RT III transcription factor, TFIIIB RL Cell 71:1055-1064 (1992). XX // AC T00069 XX ID T00069 XX DT 09.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA BrlA XX OS Aspergillus nidulans (Emericella nidulans) OC eukaryota; plantae; thallobionta; eumycota; ascomycotina; OC plectomycetes; eurotiales; trichocomaceae XX CL C0001; CH; 2.3.2.3.6. XX SZ 45 kDa (gene) XX SQ MRNQSSLSDRLTVEVDCSSLGSNECPSMTSSFSPLESPTPTPTSIYSQGSLESPGWHGAG SQ SLPNNTYERTPGSASMRSAFRLAGMASTESLGLPYGSMEGQERMPMPDFLSGYDENIEQL SQ WMPSEAPKSYDHVAQGLAYHQGMHQYPTMARNTNNNYRHQAAAYLPESTTNPCLSRSIFH SQ QPERVPSSMSSSMSMNNMLPWMNLGDSIAPQTIAPSQVGPVTPPPSYTDFPTSLSAFKQH SQ SPTTPIRSCSLGTGSGADTPLSRLSGGPCEYMDDFQPSPVYRDGFQRPHRVASRKMLRRQ SQ TSKQNLMLENLPQVIKQVQFKCKEPGCNGRFKRQEHLKRHMKSHSKEKPHVCWVPGCHRA SQ FSRSDNLNAHYTKTHSKRGGRNRYVATLDENSPDYDPEFRGQLTPDGRPIYGSKLDDPIP SQ GAGDMSLDGWDE XX SC SwissProt #P10069 XX SF 2 zinc finger motifs XX FF required for asexual reproductive pathway XX DR EMBL: M20631; ANBRLA(g). DR SwissProt: P10069; BRLA_EMENI. DR PIR: A28913; A28913. XX RN [1] RA Adams T. H., Deising H., Timberlake W. E. RT brlA requires both zinc fingers to induce development RL Mol. Cell. Biol. 10:1815-1817 (1990). RN [2] RA Adams T. H., Boylan M. T., Timberlake W. E. RT brIA is necessary and sufficient to direct conidiophore RT development in Aspergillus nidulans RL Cell 54:353-362 (1988). XX // AC T00070 XX ID T00070 XX DT 15.10.92 (created); ewi. DT 20.05.96 (updated); ewi. XX FA Pax-5 XX SY B-cell specific activator protein; BSAP; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO TSAP (sea urchin) XX CL C0017; paired; 3.2.2.0.3. XX SZ 391 AA; 42.1 kDa (cDNA), 50 kDa (SDS) [3]; XX SQ MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV SQ SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLA SQ ERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS SQ ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV SQ FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYP SQ IVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRF SQ PNPGLLGSPYYYSAAARGAAPPAAATAYDRH XX SC SwissProt #Q02548 XX FT 16 141 paired domain XX SF intact paired domain required for recognition of all SF Pax-5 binding sites [2]; SF a C-terminally truncated paired domain recognizes a subset of sites [2]; XX CP (pro-, pre-, mature B cells) XX MX M00143; V$PAX5_01 MX M00144; V$PAX5_02 XX BS R02128; BSAP$CONS; Quality: 2 BS R04285; HS$CD19_01; Quality: 4; human, Homo sapiens BS R04286; HS$CD19_02; Quality: 4; human, Homo sapiens BS R01666; SU$H2A21_02; Quality: 6; sea urchin BS R01667; SU$H2A22_01; Quality: 6; sea urchin BS R01662; SU$H2B21_02; Quality: 6; sea urchin BS R01663; SU$H2B22_01; Quality: 6; sea urchin XX DR EMBL: M96944; HSBSAP(r). DR SwissProt: Q02548; PAX5_HUMAN. DR PIR: A44063; A44063. XX RN [1] RA Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M. RT The promoter of the CD19 gene is a target for the RT B-cell-specific transcription factor BSAP RL Mol. Cell. Biol. 12:2662-2672 (1992). RN [2] RA Czerny T., Schaffner G., Busslinger M. RT DNA sequence recognition by Pax proteins: bipartite RT structure of the paired domain and its binding site RL Genes Dev. 7:2048-2061 (1993). RN [3] RA Barberis A., Widenhorn K., Vitelli L., Busslinger M. RT A novel B-cell lineage-specific transcription factor RT present at early but not late stages of differentiation RL Genes Dev. 4:849-859 (1990). RN [4] RA Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek RA P., Maurer-Fogy I., Busslinger M. RT Pax-5 encodes the transcription factor BSAP and is RT expressed in B lymphocytes, the developing CNS, and adult testis RL Genes Dev. 6:1589-1607 (1992). XX // AC T00071 XX ID T00071 XX DT 14.04.93 (created); ewi. DT 08.01.96 (updated); hiwi. XX FA B-TFIID XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO TFIIIB XX SZ 300 kDa XX SF composition: TBP + TAF-170 (+ TAF-L ?) XX FF activates pol II transcription (AdMLP), but does not FF support stimulation by acidic or Q-rich activation domains; FF (d)ATPase activity; FF activates pol III promoters XX RN [1] RA Timmers H. T. M., Meyers R. E., Sharp P. A. RT Composition of transcription factor B-TFIID RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992). RN [2] RA Lobo S. M., Tanaka M., Sullivan M. L., Hernandez N. RT A TBP complex essential for transcription from TATA-less RT but not TATA-containing RNA polymerase III promoters RT is part of the TFIIIB fraction RL Cell 71:1029-1040 (1992). RN [3] RA White R. J., Jackson S. P. RT Mechanism of TATA-binding protein recruitment to a RT TATA-less class III promoter RL Cell 71:1041-1053 (1992). RN [4] RA Timmers H. T. M., Sharp P. A. RT The mammalian TFIID protein is present in two functionally RT distinct complexes RL Genes Dev. 5:1946-1956 (1991). XX // AC T00072 XX ID T00072 XX DT 10.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Byr3 XX OS fission yeast, Schizosaccharomyces pombe OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX HO CNBP (human) XX CL C0001; CH; 2.5.2.0.1. XX SZ 179 AA XX SQ MESESVPTVPQTTRPGPRCYNCGENGHQARECTKGSICYNCNQTGHKASECTEPQQEKTC SQ YACGTAGHLVRDCPSSPNPRQGAECYKCGRVGHIARDCRTNGQQSGGRFGGHRSNMNCYA SQ CGSYGHQARDCTMGVKCYSCGKIGHRSFECQQASDGQLCYKCNQPGHIAVNCTSPVIEA XX SC SwissProt #P36627 XX SF 3+1+3 zinc finger motifs XX FF suppressor of sporulation defects; FF required for conjugation XX DR EMBL: S45038; S45038(g). DR SwissProt: P36627; BYR3_SCHPO. XX RN [1] RA Xu H.-P., Rajavashisht T., Grewal N., Jung V., Riggs RA M., Rogers L., Wigler M. RT A gene encoding a protein with seven Zinc finger domains RT acts on the sexual differentiation pathways of Schizosaccharomyces pombe RL Mol. Biol. Cell 3:721-734 (1992). XX // AC T00073 XX ID T00073 XX DT 15.10.92 (created); ewi. XX FA gammaCAAT XX SY CP1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (erythroid cells) XX BS R00563; HS$GG_17; Quality: 6; human, Homo sapiens XX RN [1] RA Gumucio D. L., Rood K. L., Gray T. A., Riordan M. RA F., Sartor C. I., Collins F. S. RT Nuclear Proteins That Bind the Human gamma-Globin RT Gene Promoter: Alterations in Binding Produced by RT Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin RL Mol. Cell. Biol. 8:5310-5322 (1988). XX // AC T00074 XX ID T00074 XX DT 15.10.92 (created); ewi. XX FA gammaCAC1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (erythroid cells) XX BS R00559; HS$GG_13; Quality: 6; human, Homo sapiens XX RN [1] RA Gumucio D. L., Rood K. L., Gray T. A., Riordan M. RA F., Sartor C. I., Collins F. S. RT Nuclear Proteins That Bind the Human gamma-Globin RT Gene Promoter: Alterations in Binding Produced by RT Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin RL Mol. Cell. Biol. 8:5310-5322 (1988). XX // AC T00075 XX ID T00075 XX DT 15.10.92 (created); ewi. XX FA gammaCAC2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (erythroid cells) XX BS R00559; HS$GG_13; Quality: 6; human, Homo sapiens XX RN [1] RA Gumucio D. L., Rood K. L., Gray T. A., Riordan M. RA F., Sartor C. I., Collins F. S. RT Nuclear Proteins That Bind the Human gamma-Globin RT Gene Promoter: Alterations in Binding Produced by RT Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin RL Mol. Cell. Biol. 8:5310-5322 (1988). XX // AC T00076 XX ID T00076 XX DT 15.10.92 (created); ewi. XX FA CAC-binding protein XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R04336; HS$AG_15; Quality: 6; human, Homo sapiens BS R04290; HS$BG_17; Quality: 5; human, Homo sapiens BS R04291; HS$BG_18; Quality: 5; human, Homo sapiens BS R04295; HS$BG_22; Quality: 5; human, Homo sapiens BS R01251; HS$PBGD_05; Quality: 6; human, Homo sapiens BS R01252; HS$PBGD_06; Quality: 6; human, Homo sapiens BS R01255; HS$PBGD_09; Quality: 6; human, Homo sapiens BS R03201; MOUSE$PBGD_01; Quality: 6; mouse, Mus musculus XX RN [1] RA Mignotte V., Wall L., deBoer E., Grosveld F., Romeo P.-H. RT Two tissue-specific factors bind to the erythroid RT promoter of the human porphobilinogen deaminase gene RL Nucleic Acids Res. 17:37-54 (1989). RN [2] RA Frampton J., Walker M., Plumb M., Harrison P. R. RT Synergy between the NF-E1 erythroid-specific transcription RT factor and the CACCC factor in the erythroid-specific RT promoter of the human porphobilinogen deaminase gene RL Mol. Cell. Biol. 10:3838-3842 (1990). XX // AC T00077 XX ID T00077 XX DT 15.10.92 (created); ewi. DT 29.08.96 (updated); ewi. XX FA CACCC-binding factor XX SY htbeta; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO NF-1B XX CL C0001; CH; . XX SZ 454 AA; 52.6 kDa (cDNA) XX SQ MNIDDKLEGLFLKCGGIDEMQSSRTMVVMGGVSGQSTVSGELQDSVLQDRSMPHQEILAA SQ DEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITF SQ TDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAF SQ RTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRSIQKY SQ HMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRIGHENHDKKLNTCAMKGGLLRSEED SQ SGFSTSPKDNSLPKKKRQKTEKKSSGMDKESALDKSDLKKDKNDYLPVYSSSTKVKDEYM SQ VAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNHTISPLSTYEER SQ KFQSMLLNLWINRLYWTQKAMLTLIRLIICRRAQ XX SC translated from EMBL #L04282 XX FT 56 98 acidic region FT 129 153 basic region FT 173 278 4 zinc finger motifs FT 314 329 basic region XX CP (HeLa; T cells) XX FF transcriptional activator, counteracting the TCR alpha gene silencer XX BS R04243; AS$CACCC_01; Quality: 2 BS R00531; CHICK$BAG_05; Quality: 6; chick, Gallus gallus BS R03441; HS$AG_12; Quality: 6; human, Homo sapiens BS R03663; HS$APOB_12; Quality: 6; human, Homo sapiens BS R03666; HS$APOB_15; Quality: 6; human, Homo sapiens BS R00520; HS$BG_01; Quality: 6; human, Homo sapiens BS R00560; HS$GG_14; Quality: 6; human, Homo sapiens BS R00596; HS$GP2B_01; Quality: 6; human, Homo sapiens BS R01474; RAT$TOA_02; Quality: 6; rat, Rattus norvegicus XX DR EMBL: L04282; HSTB(r). XX RN [1] RA Wang Y., Kobori J. K., Hood L. RT The ht¤ gene encodes a novel CACCC box-binding protein RT that regulates T-cell receptor gene expression RL Mol. Cell. Biol. 13:5691-5701 (1993). RN [2] RA Schuele R., Mueller M., Otsuka-Murakami H., Renkawitz R. RT Cooperativity of the glucocorticoid receptor and the RT CACCC-box binding factor RL Nature 332:87-90 (1988). RN [3] RA Mantovani R., Malgarettie N., Nicolis S., Giglioni RA B., Comi P., Cappelini N., Bertero M. T., Caligaris-Cappio F., Ottolenghi S. RT An erythroid specific nuclear factor binding to the RT proximal CACCC box of the beta-globin gene promoter RL Nucleic Acids Res. 16:4299-4313 (1988). RN [4] RA Catala F., deBoer E., Habets G., Grosveld F. RT Nuclear protein factors and erythroid transcription RT of the human Agamma-globin gene RL Nucleic Acids Res. 17:3811-3827 (1989). XX // AC T00078 XX ID T00078 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA CArG box-binding protein XX SY ECF1; ECF2; ECF3; XX OS clawed frog, Xenopus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX HO CBF (3), SRF XX BS R00048; XENLA$AC_01; Quality: 4; clawed frog, Xenopus laevis BS R00049; XENLA$AC_02; Quality: 4; clawed frog, Xenopus laevis BS R00050; XENLA$AC_03; Quality: 4; clawed frog, Xenopus laevis XX RN [1] RA Mohun T. J., Taylor M. V., Garrett N., Gurdon J. B. RT The CArG promoter sequence is necessary for muscle-specific RT transcription of the cardiac actin gene in Xenopus embryos RL EMBO J. 8:1153-1161 (1989). RN [2] RA Taylor M. V. RT A family of muscle gene promoter element (CArG) binding RT activities in Xenopus embryos: CArG/SRE discrimination RT and distribution during myogenesis RL Nucleic Acids Res. 19:2669 (1991). XX // AC T00079 XX ID T00079 XX DT 30.11.92 (created); ewi. DT 06.12.96 (updated); ewi. XX FA Cad XX SY Caudal; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0006; homeo; 3.1.1.3.1. XX SZ 472 AA; 51.3 kDa (gene) XX SQ MELDAQLPPHAAEPQFLGDVDSSHAAHHAAAAHQMYYNSHHMFHSAAAASAGEWHSPASS SQ TADNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSAGAPGAPQLNETNSSIGVGGA SQ GVGGGVGGATDGGPGSAAPNHQQHIAEGLPSPPITVSGSEISSPGAPTSASSPHHHLAHH SQ LSAVANNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKPAYPAQPQPGKT SQ RTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERT SQ SNKKGSDPNVMGVGVQHADYSQLLDAKTKLEPGLHLSHSLAHSMNPMAAMNIPAMRLHPH SQ LAAHSHSLAAVAAHSHQLQQQNSAQMSLRAQWARSRCDTTIPVMRRAATVTTTWSPIIRC SQ WVVASGWSRRRRRRRRRRRTTVRCVLQCSRSRLGLGLTLRSRSQTVSTEPKS XX SC SwissProt #P09085 XX FT 88 99 serine-rich region (10/12) FT 186 213 asparagine-rich region (20/28) FT 222 227 Antp-type hexapeptide FT 243 302 homeo domain XX FF posterior-specific activator of ftz [6]; FF Cad protein forms a concentration gradient along the FF posterior-anterior axis which is complementary to that of Bcd [4], [5], [3]; FF translation of the evenly distributed cad mRNA is repressed by Bcd [1], [2]; XX BS R02503; DROME$FTZ_29; Quality: 3; fruit fly, Drosophila melanogaster BS R02557; DROME$FTZ_30; Quality: 3; fruit fly, Drosophila melanogaster XX DR EMBL: X03062; DMCAD(r). DR EMBL: M21069; DMCADA1(g). DR EMBL: M21070; DMCADA2(g). DR SwissProt: P09085; HMCA_DROME. DR PIR: A26357; A26357. DR Flybase: FBgn0000251; cad. XX RN [1] RA Riviera-Pomar R., Niessing D., Schmidt-Ott U., Gehring W. J., Jaeckle H. RT RNA binding and translational suppression by bicoid RL Nature 379:746-749 (1996). RN [2] RA Dubnau J., Struhl G. RT RNA recognition and translational regulation by a homeodomain protein RL Nature 379:694-699 (1996). RN [3] RA Rivera-Pomar R., Lu X., Perrimon N., Taubert H., Jaeckle H. RT Activation of posterior gap gene expression in the Drosophila blastoderm RL Nature 376:253-256 (1995). RN [4] RA Mlodzik M., Fjose A., Gehring W. RT Isolation of caudal, a Drosophila homeo box-containing RT gene with maternal expression, whose transcripts form RT a concentration gradient at the pre-blastoderm stage RL EMBO J. 4:2961-2969 (1985). RN [5] RA Macdonald P., Struhl G. RT A molecular gradient in early Drosophila embryos and RT its role in specifying the body pattern RL Nature 324:537-545 (1986). RN [6] RA Dearolf C. R., Topol J., Parker C. S. RT Transcriptional regulation of the Drosophila segmentation RT gene fushi tarazu (ftz) RL BioEssays 12:109-113 (1990). XX // AC T00080 XX ID T00080 XX DT 20.10.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA CBF1 XX SY CB1; CP1; CPF1; centromere and promoter factor 1; centromere SY element-binding factor 1; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0010; bHLH; 1.2.0.0.3. XX SZ 351 AA; 39.4 kDa (gene), 55-60 kDa (SDS) [7], 64 kDa (SDS) [5]; XX SQ MNSLANNNKLSTEDEEIHSARKRGYNEEQNYSEARKKQRDQGLLSQESNDGNIDSALLSE SQ GATLKGTQSQYESGLTSNKDEKGSDDEDASVAEAAVAATVNYTDLIQGQEDSSDAHTSNQ SQ TNANGEHKDSLNGERAITPSNEGVKPNTSLEGMTSSPMESTQQSKNDMLIPLAEHDRGPE SQ HQQDDEDNDDADIDLKKDISMQPGRRGRKPTTLATTDEWKKQRKDSHKEVERRRRENINT SQ AINVLSDLLPVRESSKAAILARAAEYIQKLKETDEANIEKWTLQKLLSEQNASQLASANE SQ KLQEELGNAYKEIEYMKRVLRKEGIEYEDMHTHKKQENERKSTRSDNPHEA XX SC SwissProt #P17106 XX FT 217 237 basic domain FT 243 260 helix-loop-helix domain FT 266 351 dimerisation domain FT 80 93 acidic region A1 (7/14) FT 180 194 acidic region A2 (9/15) XX SF a frequently observed 37-kDa protein with identical SF DNA-binding property is a degradation product [5]; XX FF chromosome segregation [5], [6]; FF Met auxotrophy genes; FF DNA binding essential, but not sufficient for function; FF a T residue 5' to the CANNTG consensus appears to be mandatory [3]; XX IN T00080; CBF1; yeast, Saccharomyces cerevisiae. XX BS R03857; AS$CDE1_01; Quality: 5 BS R03746; CPF1$CONS; Quality: 6; yeast, Saccharomyces cerevisiae BS R03743; Y$CEN12_01; Quality: 6; yeast, Saccharomyces cerevisiae BS R03745; Y$CEN6_01; Quality: 6; yeast, Saccharomyces cerevisiae BS R03744; Y$CEN9_01; Quality: 6; yeast, Saccharomyces cerevisiae XX DR EMBL: M33620; SCCFB1A(g). DR EMBL: X52137; SCCP1(g). DR EMBL: M34070; SCCP1A(g). DR SwissProt: P17106; CBF1_YEAST. DR PIR: S12204; JSBYP1. XX RN [1] RA Dowell S. J., Tsang J. S. H., Mellor J. RT The centromere and promoter factor 1 of yeast contains RT a dimerisation domain located carboxy-terminal to the bHLH domain RL Nucleic Acids Res. 20:4229-4236 (1992). RN [2] RA Masison D. C., O'Connell K. F., Baker R. E. RT Mutational analysis of the Saccharomyces cerevisiae RT general regulatory factor CP1 RL Nucleic Acids Res. 21:4133-4141 (1993). RN [3] RA Fisher F., Goding C. R. RT Single amino acid substitutions alter helix--loop--helix RT protein specificity for bases flanking the core CANNTG motif RL EMBO J. 11:4103-4109 (1992). RN [4] RA Niedenthal R., Stoll R., Hegemann J. H. RT In vivo characterization of the Saccharomyces cerevisiae RT centromere DNA element I, a binding site for the helix-loop-helix RT protein CPF1 RL Mol. Cell. Biol. 11:3545-3553 (1991). RN [5] RA Mellor J., Jiang W., Funk M., Rathjen J., Barnes C. RA A., Hinz T., Hegemann J. H., Philippsen P. RT CPF1, a yeast protein which functions in centromeres and promoters RL EMBO J. 9:4017-4026 (1990). RN [6] RA Cai M., Davis R. W. RT Yeast chromosome binding protein CBF1, of the helix-loop-helix RT protein family, is required for chromosome stability RT and methionine prototrophy RL Cell 61:437-446 (1990). RN [7] RA Baker R. E., Masison D. C. RT Isolation of the gene encoding the Saccharomyces cerevisiae RT centromere-binding protein CP1 RL Mol. Cell. Biol. 10:2458-2467 (1990). RN [8] RA Dang C. V., Dolde C., Gillison M. L., Kato G. J. RT Discrimination between related DNA sites by a single RT amino acid residue of Myc-related basic-helix-loop-helix proteins RL Proc. Natl. Acad. Sci. USA 89:599-602 (1992). RN [9] RA Cai M., Davis R. W. RT Yeast chromosome binding protein CBF1, of the helix-loop-helix RT protein family, is required for chromosome stability RT and methionine prototrophy RL Cell 61:437-446 (1990). XX // AC T00081 XX ID T00081 XX DT 25.01.93 (created); ewi. XX FA alpha-CBF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R02848; HS$GHA_10; Quality: 6; human, Homo sapiens XX RN [1] RA Andersen B., Kennedy G. C., Nilson J. H. RT A cis-acting element located between the cAMP response RT elements and CCAAT box augments cell-specific expression RT of the glycoprotein hormone alpha-subunit gene RL J. Biol. Chem. 265:21874-21880 (1990). XX // AC T00082 XX ID T00082 XX DT 15.10.92 (created); ewi. XX FA CBF (1) XX OS sea urchin OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida XX BS R00668; SP$H2B1_02; Quality: 6; sea urchin, Strongylocentrotus purpuratus XX RN [1] RA Barberis A., Superti-Furga G., Busslinger M. RT Mutually Exclusive Interaction of the CCAAT-Binding RT Factor and of a Displacement Protein with Overlapping RT Sequences of a Histone Gene Promoter RL Cell 50:347-359 (1987). XX // AC T00083 XX ID T00083 XX DT 15.10.92 (created); ewi. DT 08.04.94 (updated); hwi; ewi. XX FA CBF (2) XX SY CCAAT-binding factor; CP1 (human, rat); NF-Y; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 39 + 41 kDa XX MX M00209; V$NFY_C XX BS R00022; HS$AAC_02; Quality: 6; human, Homo sapiens BS R00228; MOUSE$A11COL_01; Quality: 6; mouse, Mus musculus BS R00232; MOUSE$A21COL_04; Quality: 6; mouse, Mus musculus XX DR EMBL: X55315; MMNFYA(r). DR EMBL: M86214; MMNFYA1(r). DR EMBL: M86215; MMNFYAB(r). DR EMBL: X55316; MMNFYB(r). DR SwissProt: P22569; CBFA_MOUSE. DR SwissProt: P23708; CBFB_MOUSE. DR PIR: A23792; A23792. DR PIR: F38245; F38245. DR PIR: S12044; S12044. DR PIR: S12045; S12045. XX RN [1] RA Maity S. N., Sinha S., Ruteshouser E. C., de Crombrugghe B. RT Three different polypeptides are necessary for DNA RT binding of the mammalian heteromeric CCAAT binding factor RL J. Biol. Chem. 267:16574-16580 (1992). RN [2] RA Maity S. N., Golumbek P. T., Karsenty G., de Crombrugghe B. RT Selective Activation of Transcription by a Novel CCAAT Binding Factor RL Science 241:582-584 (1988). RN [3] RA Karsenty G., Golumbek P., de Crombrugghe B. RT Point Mutations and Small Substitution Mutations in RT Three Different Upstream Elements Inhibit the Activity RT of the Mouse alpha2(I) Collagen Promoter RL J. Biol. Chem. 263:13909-13915 (1988). RN [4] RA Hooft van Huijsduijnen R., Li X. Y., Black D., Matthes RA H., Benoist C., Mathis D. RT Co-evolution from yeast to mouse: cDNA cloning of RT the two NF-Y (CP-1/CBF) subunits RL EMBO J. 9:3119-3127 (1990). XX // AC T00084 XX ID T00084 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA CBF (2) XX SY CBF-A + CBF-B; CCAAT-binding factor; CP1; NF-Y (mouse); XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO AIC1 XX SF consists of two subunits: CBF-A and CBF-B XX MX M00209; V$NFY_C XX BS R02959; HS$APOA1_02; Quality: 6; human, Homo sapiens BS R00090; MOUSE$ALBU_09; Quality: 2; mouse, Mus musculus BS R00577; RAT$A2UG_05; Quality: 5; rat, Rattus norvegicus BS R01799; RAT$ALDB_02; Quality: 6; rat, Rattus norvegicus BS R02782; RAT$CY2E1_03; Quality: 6; rat, Rattus norvegicus BS R00445; RAT$GF_05; Quality: 6; rat, Rattus norvegicus XX DR EMBL: M55045; RNCBFA1(r). DR EMBL: M34238; RNCBFB(r). DR SwissProt: P18576; CBFB_RAT. DR SwissProt: P22568; CBFX_RAT. DR PIR: A23677; A23677. DR PIR: A35777; A35777. XX RN [1] RA Maity S. N., Sinha S., Ruteshouser E. C., de Crombrugghe B. RT Three different polypeptides are necessary for DNA RT binding of the mammalian heteromeric CCAAT binding factor RL J. Biol. Chem. 267:16574-16580 (1992). RN [2] RA Hatamochi A., Golumbek P. T., Van Schaftingen E., de Crombugghe B. RT A CCAAT DNA Binding Factor Consisting of Two Different RT Components That Are Both Required for DNA Binding RL J. Biol. Chem. 263:5940-5947 (1988). RN [3] RA Oikarinen J., Hatamochi A., de Crombrugghe B. RT Separate Binding Sites for Nuclear Factor 1 and a RT CCAAT DNA Binding Factor in the Mouse alpha2(I) Collagen Promoter RL J. Biol. Chem. 262:11064-11070 (1987). RN [4] RA Morgan J. G., Courtois G., Fourel G., Chodosh L. A., RA Campbell L., Evans E., Crabtree G. R. RT Sp1, a CAAT-Binding Factor, and the Adenovirus Major RT Late Promoter Transcription Factor Interact with Functional RT Regions of the Gamma-Fibrinogen Promoter RL Mol. Cell. Biol. 8:2628-2637 (1988). RN [5] RA Maity S. N., Vourio T., de Crombrugghe B. RT The B subunit of a rat heteromeric CCAAT-binding transcription RT factor shows a striking sequence identity with the RT yeast Hap2 transcription factor RL Proc. Natl. Acad. Sci. USA 87:5378-5382 (1990). RN [6] RA Vuorio T., Maity S. N., de Crombrugghe B. RT Purification and molecular cloning of the A chain RT of a rat heteromeric CCAAT-binding protein. Sequence RT identity with the yeast HAP3 transcription factor RL J. Biol. Chem. 265:22480-22486 (1990). RN [7] RA Karsenty G., de Crombrugghe B. RT Two different negative and one positive regulatory RT factors interact with a short promoter segment of RT the alpha1(I) collagen gene RL J. Biol. Chem. 265:9934-9942 (1990). XX // AC T00085 XX ID T00085 XX DT 14.12.92 (created); ewi. XX FA CBF (4) XX SY cap-site binding factor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01002; AD$MLP_17; Quality: 6; adenovirus type 5 BS R01757; HS$AAC_12; Quality: 6; human, Homo sapiens XX RN [1] RA Garfinkel S., Thompson J. A., Jacob W. F., Cohen R., Safer B. RT Identification and Characterization of an Adenovirus RT 2 Major Late Promoter CAP Sequence DNA-Binding Protein RL J. Biol. Chem. 265:10309-10319 (1990). XX // AC T00086 XX ID T00086 XX DT 26.01.93 (created); ewi. DT 27.08.96 (updated); ewi. XX FA CBF (5) XX SY CCAAT-binding factor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 998 AA; 114.1 kDa (cDNA) XX SQ MAAVKEPLEFHAKRPWRPEEAVEDPDEEDEDNTSEAENGFSLEEVLRLGGTKQDYLMLAT SQ LDENEEVIDGGKKGAIDDLQQGELEAFIQNLNLAKYTKASLIEEDEPAEKENSSKKEVKI SQ PKINNKNTAESQRTSVNKVKNKNRPEPHSDENGSTTPKVKKDKQNIFEFFERQTLLLRPG SQ GKWYDLEYSNEYSLKPQPQDVVSKYKTLAQKLYQHEINLFKSKTNSQKGASSTWMKAIVS SQ SGTLGDRMAAMILLIQDDAVHTLQFVETLVNLVKKKGSKQQCLMALDTFKELLITDLLPD SQ NRKLRIFSQRPFDKLEQLSSGNKDSRDRRLILWYFEHQLKHLVAEFVQVLETLSHDTLVT SQ TKTRALTVAHELLCNKPEEEKALLVQVVNKLGDPQNRIATKASHLLETLLCKHPNMKGVV SQ SGEVERLLFRSNISSKAQYYAICFLNQMALSHEESELANKLITVYFCFFRTCVKKKDVES SQ KMLSALLTGVNRAYPYSQTGDDKVREQIDTLFKVLHIVNFNTSVQALMLLFQVMNSQQTI SQ SDRYYTALYRKMLDPGLMTCSKQAMFLNLVYKSLKADIVLRRVKAFVKGLLQVTCQQMPP SQ FICGALYLVSEILKAKPGLRSQLDDHPESDDEENFIDANDDEDMEKFTDADKETEIVKKL SQ ETEETVPETDVETKKPEVASWVHFDNLKGGKQLNKYDPFSRNPLFCGAENTSLWELKKLS SQ VHFHPSVALFAKTILQGNYIQYSGDPLQDFTLMRFLDRFVYRNPKPHKGKENTDSVVMQP SQ KRKHFIKDIRHLPVNSKEFLAKEESQIPVDEVFFHRYYKKVAVKEKQKRDADEESIEDVD SQ DEEFEELIDTFEDDNCFSSGKDDMDFAGNVKKRTKGAKDNTLDEDSEGSDDELGNLDDDE SQ VSLGSMDDEEFAEVDEDGGTFMDVLDDESESVPELEVHSKVSTKKSKRKGTDDFDFAGSF SQ QGPRKKKRNLNDSSLFVSAEEFGHLLDENMGSKFDNIA XX SC translated from EMBL #M37197 XX SF acidic region XX FF different from CBF-A and CBF-B XX DR EMBL: M37197; HSCBF(r). DR Compel: C00004 XX RN [1] RA Lum L. S. Y., Sultzman L. A., Kaufman R. J., Linzer D. L. H., Wu B. J. RT A cloned human CCAAT-box-binding factor stimulates RT transcription from the human hsp70 promoter RL Mol. Cell. Biol. 10:6709-6717 (1990). XX // AC T00087 XX ID T00087 XX DT 26.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CBF-A XX SY CP1-A; HAP3 (yeast); NF-YB (mouse); XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 1.6.1.0.1. XX SZ 207 AA; 25 kDa (cDNA); 32 kDa (SDS) XX SQ MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLP SQ IANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILF SQ AMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVSATDGLSEELTEEAFTNQLPAGLIT SQ ADGQQQNVMVYTTSYQQISGVQQIQFS XX SC SwissProt #P22569 XX FT 63 102 CBF-C interaction domain 1 [2]; FT 109 142 CBF-C interaction domain 2 [2]; FT 92 99 CBF-B interaction domain in A/C-heterodimer [2]; FT 57 87 DNA-binding domain (DBD) within A/B/C heterotrimer [2]; FT 64 125 histone-fold motif [2]; XX IN T00088; CBF-B; rat, Rattus norvegicus. IN T00157; CP1B; human, Homo sapiens. IN T00347; HAP2; human, Homo sapiens. IN T00349; HAP2; yeast, Saccharomyces cerevisiae. IN T00351; HAP4; yeast, Saccharomyces cerevisiae. IN T00615; NF-YA; mouse, Mus musculus. IN T01595; CBF-C; rat, Rattus norvegicus. XX MX M00209; V$NFY_C XX BS R00232; MOUSE$A21COL_04; Quality: 6; mouse, Mus musculus XX DR EMBL: M55045; RNCBFA1(r). DR SwissProt: P22569; CBFA_MOUSE. DR PIR: A23692; A23692. DR PIR: F38245; F38245. DR PIR: S12045; S12045. XX RN [1] RA Maity S. N., Sinha S., Ruteshouser E. C., de Crombrugghe B. RT Three different polypeptides are necessary for DNA RT binding of the mammalian heteromeric CCAAT binding factor RL J. Biol. Chem. 267:16574-16580 (1992). RN [2] RA Sinha S., Kim I.-S., Sohn K.-Y., Crombrugghe B., Maity S. N. RT Three classes of mutations in the A subunit of the RT CCAAT-binding factor CBF delineate functional domains RT involved in the three-step assembly of the CBF-DNA complex RL Mol. Cell. Biol. 16:328-337 (1996). RN [3] RA Vuorio T., Maity S. N., de Crombrugghe B. RT Purification and molecular cloning of the A chain RT of a rat heteromeric CCAAT-binding protein. Sequence RT identity with the yeast HAP3 transcription factor RL J. Biol. Chem. 265:22480-22486 (1990). XX // AC T00088 XX ID T00088 XX DT 26.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CBF-B XX SY CP1-B; HAP2 (yeast); NF-YA (mouse); XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 1.6.1.0.2. XX SZ 341 AA; 41 kDa (cDNA); 37-40 kDa (SDS) XX SQ MEQYTANSNSSTEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPL SQ MVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAV SQ QVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTIL SQ QQGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMVPGAGSV SQ PAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHESRHRH SQ AMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS XX SC SwissProt #P18576 XX FT 14 161 glutamine-rich region FT 200 216 serine-/threonine-rich region FT 252 334 interaction with CBF-A and DNA FT 260 312 HAP2 homologous region FT 267 306 basic region FT 6 247 trans-activation domain [1]; XX SF both the Gln- and the Ser-/Thr-rich region contribute SF to the transcriptional activation by CBF-B, each per SF se modestly activating [1]; SF trans-activation activity in whole CBF redundant [1]; XX FF activator [1], contributes to the activation potential FF of the whole CBF multimeric factor complex [1]; XX IN T00087; CBF-A; rat, Rattus norvegicus. IN T00154; CP1A; human, Homo sapiens. IN T00350; HAP3; yeast, Saccharomyces cerevisiae. IN T00351; HAP4; yeast, Saccharomyces cerevisiae. IN T00616; NF-YB; mouse, Mus musculus. IN T01263; HAP3; fission yeast, Schizosaccharomyces pombe. XX MX M00209; V$NFY_C XX BS R00232; MOUSE$A21COL_04; Quality: 6; mouse, Mus musculus XX DR EMBL: M34238; RNCBFB(r). DR SwissProt: P18576; CBFB_RAT. DR PIR: A35777; A35777. XX RN [1] RA Coustry P., Maity S. N., de Crombrugghe B. RT Studies on transcriptional activation by the multimeric RT CCAAT-binding factor CBF RL J. Biol. Chem. 270:468-475 (1995). RN [2] RA Maity S. N., Vuorio T., de Crombrugghe B. RT The B subunit of a rat heteromeric CCAAT-binding transcription RT factor shows a striking sequence identity with the RT yeast Hap2 transcription factor RL Proc. Natl. Acad. Sci. USA 87:5378-5382 (1990). XX // AC T00089 XX ID T00089 XX DT 15.10.92 (created); ewi. XX FA CBP XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01456; HS$TF_07; Quality: 6; human, Homo sapiens XX RN [1] RA Brunel F., Ochoa A., Schaeffer E., Boissier F., Guillou RA Y., Cereghini S., Cohen G. N., Zakin M. M. RT Interaction of DNA-binding Proteins with the 5' Region RT of the Human Transferrin Gene RL J. Biol. Chem. 263:10180-10185 (1988). RN [2] RA Wu B. J., Williams G. T., Morimoto R. I. RT Detection of three protein binding sites in the serum-regulated RT promoter of the human gene encoding the 70-kDa heat shock protein RL Proc. Natl. Acad. Sci. USA 84:2203-2207 (1987). XX // AC T00090 XX ID T00090 XX DT 15.10.92 (created); ewi. DT 23.05.97 (updated); hiwi. XX FA CBP XX SY CREB-binding protein; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO C/EBP, CTF XX SZ 2441 AA; 265.5 kDa (cDNA) XX SQ MAENLLDGPPNPKRAKLSSPGFSANDNTDFGSLFDLENDLPDELIPNGELSLLNSGNLVP SQ DAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSTNMASLGAMGKS SQ PLNQGDSSTPNLPKQAASTSGPTPPASQALNPQAQKQVGLVTSSPATSQTGPGICMNANF SQ NQTHPGLLNSNSGHSLMNQAQQGQAQVMNGSLGAAGRGRGAGMPYPAPAMQGATSSVLAE SQ TLTQVSPQMAGHAGLNTAQAGGMTKMGMTGTTSPFGQPFSQTGGQQMGATGVNPQLASKQ SQ SMVNSLPAFPTDIKNTSVTTVPNMSQLQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLL SQ LHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAPKACQVAHCASSRQIISHWKN SQ CTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGAGQQNATSLSNPNPIDPSSM SQ QRAYAALGLPYMNQPQTQLQPQVPGQQPAQPPAHQQMRTLNALGNNPMSVPAGGITTDQQ SQ PPNLISESALPTSLGATNPLMNDGSNSGNIGSLSTIPTAAPPSSTGVRKGWHEHVTQDLR SQ SHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKI SQ QKELEEKRRTRLHKQGILGNQPALPASGAQPPVIPPAQSVRPPNGPLPLPVNRMQVSQGM SQ NSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMASVPGMAISPSRMPQPPNMMGTHAN SQ NIMAQAPTQNQFLPQNQFPSSSGAMSVNSVGMGQPAAQAGVSQGQEPGAALPNPLNMLAP SQ QASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHPTAPGMTPPQPAAPTQPSTPVSSGQTP SQ TPTPGSVPSAAQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHTQPPGT SQ PLSQAAASIDNRVPTPSTVTSAETSSQQPGPDVPMLEMKTEVQTDDAEPEPTESKGEPRS SQ EMMEEDLQGSSQVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSSNDTASQSTSPSQ SQ PRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIK SQ RKLDTGQYQEPWQYVDDVRLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYC SQ CGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCGKCFTEIQGENVTLGDDPSQPQ SQ TTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPR SQ KENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRF SQ VDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQDTALIAPHQIQGCVYISYLDSIHF SQ FRPRCLRTAVYHEILIGYLEYVKKLVYVTAHIWACPPSEGDDYIFHCHPPDQKIPKPKRL SQ QEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSAKELPYFEGDFWPNVLEESIKELEQE SQ EEERKKEESTAASETPEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQ SQ KLYATMEKHKEVFFVIHLHAGPVISTQPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFS SQ SLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHT SQ HKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMK SQ RVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHNVRQQQIQHCL SQ QQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVNMSPA SQ GFPNVARTQPPTIVSAGKPTNQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRANINN SQ GMPPGRDGMGTPGSQMTPVGLNVPRPNQVSGPVMSSMPPGQWQQAPIPQQQPMPGMPRPV SQ MSMQAQAAVAGPRMPNVQPNRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAA SQ FIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPPQP SQ AMGGLNPQGQALNIMNPGHNPNMTNMNPQYREMVRRQLLQHQQQQQQQQQQQQQQQNSAS SQ LAGGMAGHSQFQQPQGPGGYAPAMQQQRMQQHLPIQGSSMGQMAAPMGQLGQMGQPGLGA SQ DSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSN SQ QVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGTPHPGLAVTMASSMDQGHLG SQ NPEQSAMLPQLNTPNRSALSSELSLVGDTTGDTLEKFVEGL XX SC SwissProt # P45481 XX FT 461 661 binding to CREB [1], c-Myb [3], c-Jun [8]; FT 1104 1176 bromo domain FT 1621 1877 binding to E1A, E2F-1 [4], c-Fos [5]; XX DR EMBL: S66385; S66385(empty). DR SwissProt: P45481; CBP_MOUSE. XX RN [1] RA Chrivia J. C., Kwok R. P. S., Lamb N., Hagiwara M., RA Montminy M. R., Goodman R. H. RT Phosphorylated CREB binds specifically to the nuclear protein CBP RL Nature 365:855-859 (1993). RN [2] RA Kwok R. P., Lundblad J. R., Chrivia J. C., Richards RA J. P., Baechinger H. P., Brennan R. G., Roberts S. RA G., Green M. R., Goodman R. H. RT Nuclear protein CBP is a coactivator for the transcription factor CREB RL Nature 370:223-226 (1994). RN [3] RA Dai P., Akimaru H., Tanaka Y., Hou D.-X., Yasukawa RA T., Kanei-Ishii C., Takahashi T., Ishii S. RT CBP as a transcriptional coactivator of c-Myb RL Genes Dev. 10:528-540 (1996). RN [4] RA Trouche D., Cook A., Kouzarides T. RT The CBP co-activator stimulates E2F1/DP1 activity RL Nucleic Acids Res. 24:4139-4145 (1996). RN [5] RA Bannister A. J., Kouzarides T. RT CBP-induced stimulation of c-Fos activity is abrogated by E1A RL EMBO J. 14:4758-4762 (1995). RN [6] RA Lundblad J. R., Kwok R. P. S., Laurance M. E., Harter M. L., Goodman R. H. RT Adenoviral E1A-associated protein p300 as a functional RT homologue of the transcriptional co-activator CBP RL Nature 374:85-88 (1995). RN [7] RA Eckner R., Ewen M. E., Newsome D., Gerdes M., DeCapiro RA J. A., Lawrence J. B., Livingston D. M. RT Molecular cloning and functional analysis of the adenovirus RT E1A-associated 300-kD protein (p300) reveals a protein RT with properties of a transcriptional adaptor RL Genes Dev. 8:869-884 (1994). RN [8] RA Bannister A. J., Oehler T., Wilhelm D., Angel P., Kouzarides T. RT Stimulation of c-Jun activity by CBP: c-Jun residues RT Ser63/73 are required for CBP induced stimulation RT in vivo and CBP binding in vitro RL Oncogene 11:2509-2514 (1995). RN [9] RA Cohen R. B., Sheffery M., Kim C. G. RT Partial purification of a nuclear protein that binds RT to the CCAAT box of the mouse alpha1-globin gene RL Mol. Cell. Biol. 6:821-832 (1986). XX // AC T00091 XX ID T00091 XX DT 26.01.93 (created); hse. XX FA CBP-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 39-49 kDa (SDS) XX FF heat stable, centromere (CDE I) binding protein, implicated FF in chromosome segregation and transcriptional activation XX BS R02130; CBP1$CONS; Quality: 2 XX RN [1] RA Cai M., Davis R. W. RT Yeast chromosome binding protein CBF1, of the helix-loop-helix RT protein family, is required for chromosome stability RT and methionine prototrophy RL Cell 61:437-446 (1990). RN [2] RA Bram R. J., Kornberg R. D. RT Isolation of a Saccharomyces cerevisiae centromere RT DNA-binding protein,its human homolog, and its possible RT role as a transcription factor RL Mol. Cell. Biol. 7:403-409 (1987). RN [3] RA Baker R. E., Masison D. C. RT Isolation of the gene encoding the Saccharomyces cerevisiae RT centromere-binding protein CP1 RL Mol. Cell. Biol. 10:2458-2467 (1990). RN [4] RA Moncollin V., Stalder R., Verdier J.-M., Sentenac A., Egly J.-M. RT A yeast homolog of the human UEF stimulates transcription RT from the adenovirus 2 major late promoter in yeast RT and in mammalian cell-free systems RL Nucleic Acids Res. 18:4817-4823 (1990). XX // AC T00092 XX ID T00092 XX DT 15.10.92 (created); ewi. XX FA CCAAT-binding factor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00231; MOUSE$A21COL_03; Quality: 6; mouse, Mus musculus BS R03016; RAT$INS1_10; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Oikarinen J., Hatamochi A., de Crombrugghe B. RT Separate Binding Sites for Nuclear Factor 1 and a RT CCAAT DNA Binding Factor in the Mouse alpha2(I) Collagen Promoter RL J. Biol. Chem. 262:11064-11070 (1987). RN [2] RA Karsenty G., Golumbek P., de Crombrugghe B. RT Point Mutations and Small Substitution Mutations in RT Three Different Upstream Elements Inhibit the Activity RT of the Mouse alpha2(I) Collagen Promoter RL J. Biol. Chem. 263:13909-13915 (1988). XX // AC T00093 XX ID T00093 XX DT 15.10.92 (created); ewi. XX FA CCAAT-binding factor XX OS sea urchin OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida XX BS R01899; SP$H3_05; Quality: 6; sea urchin, Strongylocentrotus purpuratus XX RN [1] RA Barberis A., Superti-Furga G., Busslinger M. RT Mutually Exclusive Interaction of the CCAAT-Binding RT Factor and of a Displacement Protein with Overlapping RT Sequences of a Histone Gene Promoter RL Cell 50:347-359 (1987). XX // AC T00094 XX ID T00094 XX DT 15.10.92 (created); ewi. XX FA CCAAT-binding factor XX SY CTF; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R02028; HS$NPY_03; Quality: 6; human, Homo sapiens XX RN [1] RA Kingston R. E., Schuetz T. J., Larin Z. RT Heat-Inducible Human Factor That Binds to a Human hsp70 Promoter RL Mol. Cell. Biol. 7:1530-1534 (1987). XX // AC T00095 XX ID T00095 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA CCAAT-binding factor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO CBP, CTF, CArG-binding factor XX SZ 64 kDa ? XX BS R00511; MOUSE$AAG_05; Quality: 6; mouse, Mus musculus XX RN [1] RA Cohen R. B., Sheffery M., Kim C. G. RT Partial purification of a nuclear protein that binds RT to the CCAAT box of the mouse alpha1-globin gene RL Mol. Cell. Biol. 6:821-832 (1986). XX // AC T00096 XX ID T00096 XX DT 15.10.92 (created); ewi. DT 04.03.97 (updated); ewi. XX FA CCBF XX SY SBF; SCB; SWI4+SWI6; cell cycle box factor; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0009; ZIP; . XX SZ 1093 + 803 AA; 214.4 kDa (genes) XX SQ MALEEVVRYLGPHNEIPLTLTRDSETGHFLLKHFLPILQQYHDTGNINETNPDSFPTDEE SQ RNKLLAHYGIAVNTDDRGELWIELEKCLQLLNMLNLFGLFQDAFEFEEPETDQDEEDPSH SQ SKLPENKTKSENSKDNISSKRINNLQDMSLDSDAHRELGSPLKKLKIDTSVIDAESDSTP SQ NTARGKPNDDINKGPSGDNENNGTDDNDRTAGPIITFTHDLTSDFLSSPLKIMKALPSPV SQ VNDNEQKMKLEAFLQRLLFPEIQEMPTSLNNDSSNRNSEGGSSNQQQQHVSFDSLLQEVN SQ DAFPNTQLNLNIPVDEHGNTPLHWLTSIANLELVKHLVKHGSNRLYGDNMGESCLVKAVK SQ SVNNYDSGTFEALLDYLYPCLILEDSMNRTILHHIIITSGMTGCSAAAKYYLDILMGWIV SQ KKQNRPIQSGTNEKESKPNDKNGERKDSILENLDLKWIIANMLNAQDSNGDTCLNIAARL SQ GNISIVDALLDYGADPFIANKSGLRPVDFGAGTSKLQNTNGGDENSKMVSKGDYDGQKNG SQ KAKKIRSQLLKNPPETTSLINDVQNLLNSISKDYENETVQYNEKLEKLHKELNEQREELA SQ NSREQLANVKQLKDEYSLMQEQLTNLKAGIEEEEESFREESKKLGIIADESSGIDWDSSE SQ YDADEPFKVEFLSDFLEDKLQKNYEGDISKLLEAESKEQIMEQIRNQLPAEKIQSMLPPT SQ VLLKARINAYKRNDKHLTNVLDTISTKQSELENKFRRVLSLCLKIDENKVDNMLDGLLQA SQ ISSEDPQDIDTDEMQDFLKKHAS XX SC SwissProt #P09959 XX SF SWI4 + SWI6 complex SF the main DNA-binding component is SWI4 [3]; XX FF mediates cell-cycle dependent transcription of HO FF gene and START-specific transcription [1], [4]; XX BS R03740; CCBF$CONS_01; Quality: 6 BS R03735; Y$CLN2_01; Quality: 6; yeast, Saccharomyces cerevisiae BS R00719; Y$HO_02; Quality: 4; yeast, Saccharomyces cerevisiae BS R00720; Y$HO_03; Quality: 4; yeast, Saccharomyces cerevisiae BS R03752; Y$HO_05; Quality: 6; yeast, Saccharomyces cerevisiae XX DR EMBL: X06238; SCSW16(empty). DR SwissProt: P09959; SWI6_YEAST. DR PIR: RGBYW6; RGBYW6. XX RN [1] RA Nasmyth K., Dirick L. RT The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast RL Cell 66:995-1013 (1991). RN [2] RA Sidorova J., Breeden L. RT Analysis of the SWI4/SWI6 protein complex, which directs RT G1/S-specific transcription in Saccharomyces cerevisiae RL Mol. Cell. Biol. 13:1069-1077 (1993). RN [3] RA Andrews B. J., Moore L. A. RT Interaction of the yeast Swi4 and Swi6 cell cycle RT regulatory proteins in vitro RL Proc. Natl. Acad. Sci. USA 89:11852-11856 (1992). RN [4] RA Ogas J., Andrews B. J., Herskowitz I. RT Transcriptional activation of CLN1, CLN2, and a putative RT new G1 cyclin (HCS26) by SWI4, a positive regulator RT of G1-specific transcription RL Cell 66:1015-1026 (1991). RN [5] RA Andrews B. J., Herskowitz I. RT The yeast SWI4 protein contains a motif present in RT developmental regulators and is part of a complex RT involved in cell-cycle-dependent transcription RL Nature 342:830-833 (1989). RN [6] RA Andrews B. J., Herskowitz I. RT Identification of a DNA Binding Factor Involved in RT Cell-Cycle Control of the Yeast HO Gene RL Cell 57:21-29 (1989). XX // AC T00097 XX ID T00097 XX DT 17.11.92 (created); ewi. XX FA CCK-1a XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R02378; RAT$CCK_01; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Haun R. S., Dixon J. E. RT A transcriptional enhancer essential for the expression RT of the rat cholecystokinin gene contains a sequence RT identical to the -296 element of the human c-fos gene RL J. Biol. Chem. 265:15455-15463 (1990). XX // AC T00098 XX ID T00098 XX DT 17.11.92 (created); ewi. XX FA CCK-1b XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R02379; RAT$CCK_02; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Haun R. S., Dixon J. E. RT A transcriptional enhancer essential for the expression RT of the rat cholecystokinin gene contains a sequence RT identical to the -296 element of the human c-fos gene RL J. Biol. Chem. 265:15455-15463 (1990). XX // AC T00099 XX ID T00099 XX DT 15.10.92 (created); ewi. XX FA CDF XX OS sea urchin OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida XX BS R00669; SP$H2B1_03; Quality: 6; sea urchin, Strongylocentrotus purpuratus XX RN [1] RA Barberis A., Superti-Furga G., Busslinger M. RT Mutually Exclusive Interaction of the CCAAT-Binding RT Factor and of a Displacement Protein with Overlapping RT Sequences of a Histone Gene Promoter RL Cell 50:347-359 (1987). XX // AC T00100 XX ID T00100 XX DT 15.10.92 (created); ewi. DT 06.12.96 (updated); ewi. XX FA CDP XX SY CCAAT displacement protein; Clox; Cux; cut homeodomain protein; SY cut-like homeodomain protein; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO cut (Drosophila) XX CL C0006; homeo; 3.1.1.4.1. XX SZ 1505 AA; 164.4 kDa (cDNA), 180-200 kDa (SDS) XX SQ MLCVRGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF SQ QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE SQ TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ SQ ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN SQ QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA SQ QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI SQ LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPES SQ RRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFAL SQ NSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE SQ SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT SQ VRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRI SQ RASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDEPIRSILQQARREMEAQ SQ QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPN SQ PPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEE SQ AKARETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA SQ SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNG SQ ICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQ SQ QQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP SQ IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLT SQ DNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMD SQ MKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK SQ RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASD SQ SPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGT SQ PGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPTSAPP SQ PSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEP SQ IEWEF XX SC SwissProt #P39880 XX FT 551 610 Cut-repeat 1 (CR1) FT 943 1007 Cut-repeat 2 (CR2) FT 1135 1190 Cut-repeat 3 (CR3) FT 632 653 missing in putative splice variant FT 1245 1301 homeo domain XX SF the Clox homolog is a splice variant [3]; SF the 3 cut repeats also contribute to DNA-binding, SF each individual repeat and each combination exhibiting SF slightly different DNA-binding specificity [2], [4], [3]; SF CR1 exhibits the most restricted resognition pattern [2]; SF KD (CR3-homeo domain) = 0.03 nM, isolated CR3 at least SF 100-fold lower affinity [4]; XX FF repressor [12], [11], [1], [7], [5], [6]; XX MX M00095; V$CDP_01 MX M00102; V$CDP_02 MX M00104; V$CDPCR1_01 MX M00105; V$CDPCR3_01 MX M00106; V$CDPCR3HD_01 XX BS R03477; HS$CYBH_01; Quality: 2; human, Homo sapiens BS R00562; HS$GG_16; Quality: 6; human, Homo sapiens XX DR EMBL: M74099; HSCDP(r). DR SwissProt: P39880; CDP_HUMAN. XX RN [1] RA Skalnik D. G., Strauss E. C., Orkin S. H. RT CCAAT displacement protein as a repressor of the myelomonocytic-specific RT gp91-phox gene promoter RL J. Biol. Chem. 266:16736-16744 (1991). RN [2] RA Aufiero B., Neufeld E. J., Orkin S. H. RT Sequence-specific DNA binding of individual cut repeats RT of the human CCAAT displacement/ cut homeodomain protein RL Proc. Natl. Acad. Sci. USA 91:7757-7761 (1994). RN [3] RA Andres V., Chiara M. D., Mahdavi V. RT A new bipartite DNA-binding domain: cooperative interaction RT between the cut repeat and homeo domain of the cut homeo proteins RL Genes Dev. 8:245-257 (1994). RN [4] RA Harada R., Berube G., Tamplin O. J., Denis-Larose C., Nepveu A. RT DNA-binding specificity of the cut repeats from the human cut-like protein RL Mol. Cell. Biol. 15:129-140 (1995). RN [5] RA Dufort D., Nepveu A. RT The human Cut homeodomain protein represses transcription RT from the c-myc promoter RL Mol. Cell. Biol. 14:4251-4257 (1994). RN [6] RA Lievens P. M., Donady J. J., Tufarelli C., Neufeld E. J. RT Repressor activity of CCAAT displacement protein in RT HL-60 myeloid leukemia cells RL J. Biol. Chem. 270:12745-12750 (1995). RN [7] RA Neufeld E. J., Skalnik D. G., Lievens P. M., Orkin S. H. RT Human CCAAT dis-placement protein is homologous to RT the Drosophila homeoprotein, cut RL Nature Genet. 1:50-55 (1992). RN [8] RA Harada R., Dufort D., Denis-Larose C., Nepveu A. RT Conserved cut repeats in the human cut homeodomain RT protein function as DNA binding domains RL J. Biol. Chem. 269:2062-2067 (1994). RN [9] RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M. RT The protein CDP, but not CP1, footprints on the CCAAT RT region of the g-globin gene in unfractionated B-cell extracts RL Biochim. Biophys. Acta 1007:237-242 (1989). RN [10] RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S. RT The deletion of the distal CCAAT box region of the RT Agamma-globin gene in black HPFH abolishes the binding RT of the erythroid specific protein NFE3 and of the CCAAT displacement protein RL Nucleic Acids Res. 17:6681-6691 (1989). RN [11] RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M. RT The -117 mutation in Greek HPFH affects the binding RT of three nuclear factors to the CCAAT region of the gamma-globin gene RL EMBO J. 7:3099-3107 (1988). RN [12] RA Barberis A., Superti-Furga G., Busslinger M. RT Mutually Exclusive Interaction of the CCAAT-Binding RT Factor and of a Displacement Protein with Overlapping RT Sequences of a Histone Gene Promoter RL Cell 50:347-359 (1987). XX // AC T00101 XX ID T00101 XX DT 15.10.92 (created); ewi. XX FA CDP XX OS sea urchin OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida XX RN [1] RA Barberis A., Superti-Furga G., Busslinger M. RT Mutually Exclusive Interaction of the CCAAT-Binding RT Factor and of a Displacement Protein with Overlapping RT Sequences of a Histone Gene Promoter RL Cell 50:347-359 (1987). XX // AC T00102 XX ID T00102 XX DT 26.01.93 (created); hse. DT 10.01.96 (updated); hiwi. XX FA CD28RC XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SF UV-cross-linking: 35, 36, 44 kDa proteins XX FF activates cytokine promoters XX BS R02131; CD28RC$CONS; Quality: 1 BS R00602; HS$GMCSF_02; Quality: 4; human, Homo sapiens BS R00935; HS$IL2_06; Quality: 4; human, Homo sapiens BS R03673; HS$IL2_13; Quality: 4; human, Homo sapiens BS R02682; HS$IL3_01; Quality: 4; human, Homo sapiens XX RN [1] RA Fraser J. D., Irving B. A., Crabtree G. R., Weiss A. RT Regulation of interleukin-2 gene enhancer activity RT by the T-cell accessory molecule CD28 RL Science 251:313-316 (1991). XX // AC T00103 XX ID T00103 XX DT 12.03.93 (created); ewi. DT 08.12.95 (updated); ewi. XX FA CEBF XX SY cardiac element-binding factor; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CP heart muscle, brain, liver CN skeletal muscle XX BS R03070; CHICK$CTNT_04; Quality: 4; chick, Gallus gallus XX RN [1] RA Ianello R. C., Mar J. H., Ordahl C. P. RT Characterization of a promoter element required for RT transcription in myocardial cells RL J. Biol. Chem. 266:3309-3316 (1991). XX // AC T00104 XX ID T00104 XX DT 15.10.92 (created); ewi. DT 26.02.97 (updated); ewi. XX FA C/EBPalpha XX SY BPc; C/EBP; CBP; EBP20; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.3.0.1.1. XX SZ 359 AA; 37.7 kDa (cDNA) XX SQ MESADFYEVEPRPPMSSHLQSPPHAPSNARLWLSPGRGPRAAPSPTCRPGAAGRICEHET SQ SIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAVMSA SQ GAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQ SQ PPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHAAPALGAA SQ GLPGPGSALKGLAGAHPDLRTGGGGGGSGAGAGKAKKSVDKNSNEYRVRRERNNIAVRKS SQ RDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA XX SC SwissProt #P53566 XX FT 274 307 basic region FT 311 341 leucine zipper (TL5) FT 356 359 different N-terminus 356-395 in EMBL #M62362 FT 118 118 alternative translation codon [10]; XX SF length: 359 AA [17]; SF C/EBPalpha exhibits a very relaxed DNA-binding specificity [2]; SF the N-terminal part of the molecule exhibits antimitotic activity [10]; XX FF presumed to be involved in energy metabolism and may FF have a role in regulating the balance between cell FF growth and differentiation [14], [19]; FF Myc/Max heterodimers bind to and represses the c/ebpalpha promoter [11]; FF TNF-alpha reduces the level of C/EBPalpha and, thus, FF the expression of its target genes [4]; FF positive autoregulation [17], [11]; XX IN T00017; C/EBPbeta; mouse, Mus musculus. IN T00104; C/EBPalpha; mouse, Mus musculus. IN T00109; C/EBPdelta; rat, Rattus norvegicus. IN T00127; CHOP-10; mouse, Mus musculus. IN T00216; C/EBPgamma; mouse, Mus musculus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. IN T01114; C/EBPdelta; mouse, Mus musculus. IN T01303; CREB-2; human, Homo sapiens. XX MX M00116; V$CEBPA_01 MX M00159; V$CEBP_01 MX M00201; V$CEBP_C MX M00249; V$CHOP_01 XX BS R02132; CEBP$CONS_01; Quality: 6 BS R04246; CEBP$CONS_02; Quality: 6 BS R04247; CEBP$CONS_03; Quality: 6 BS R03666; HS$APOB_15; Quality: 4; human, Homo sapiens BS R04255; HS$APOB_39; Quality: 4; human, Homo sapiens BS R02678; MOUSE$A1PI_05; Quality: 5; mouse, Mus musculus BS R02460; MOUSE$AGP_01; Quality: 2; mouse, Mus domesticus BS R02461; MOUSE$AGP_02; Quality: 2; mouse, Mus domesticus BS R01817; MOUSE$AP2_04; Quality: 3; mouse, Mus musculus BS R01818; MOUSE$AP2_05; Quality: 3; mouse, Mus musculus BS R03135; MOUSE$CEBP_04; Quality: 2; mouse, Mus musculus BS R01700; MOUSE$GLUT4_01; Quality: 1; mouse, Mus musculus BS R01841; MOUSE$SCD1_02; Quality: 1; mouse, Mus musculus XX DR EMBL: M62362; MMCATENB(g). DR SwissProt: P53566; CEBA_MOUSE. XX RN [1] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [2] RA Costa R. H., Grayson D. R., Xanthopoulos K. G., Darnell Jr. J. E. RT A liver-specific DNA-binding protein recognizes multiple RT nucleotide sites in regulatory regions of transthyretin, RT alpha1-antitrypsin, albumin, and simian virus 40 genes RL Proc. Natl. Acad. Sci. USA 85:3840-3844 (1988). RN [3] RA Grayson D. R., Costa R. H., Xanthopoulos K. G., Darnell J. E. RT One Factor Recognizes the Liver-Specific Enhancers RT in alpha1-Antitrypsin and Transthyretin Genes RL Science 239:786-788 (1988). RN [4] RA Stephens J. M., Pekala P. H. RT Transcriptional repression of the GLUT4 and C/EBP RT genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha RL J. Biol. Chem. 266:21839-21845 (1991). RN [5] RA Milos P. M., Zaret K. S. RT A ubiquitous factor is required for C/EBP-related RT proteins to form stable transcription complexes on RT an albumin promoter segment in vitro RL Genes Dev. 6:991-1004 (1992). RN [6] RA Alam T., An M. R., Papaconstantinou J. RT Differential expression of three C/EBP isoforms in RT multiple tissues during the acute phase response RL J. Biol. Chem. 267:5021-5024 (1992). RN [7] RA Legraverend C., Antonson P., Flodby P., Xanthopoulos K. G. RT High level activity of the mouse CCAAT/enhancer binding RT protein (C/EBPalpha) gene promoter involves autoregulation RT and several ubiquitous transcription factors RL Nucleic Acids Res. 21:1735- 1742 (1993). RN [8] RA Lin F. -T., Lane M. D. RT CCAAT/enhancer binding protein alpha is sufficient RT to initiate the 3T3-L1 adipocyte differentiation program RL Proc. Natl. Acad. Sci. USA 91:8757-8761 (1994). RN [9] RA Lin F. -T., MacDougald O. A., Diehl A. M., Lane M. D. RT A 30-kDa alternative translation product of the CCAAT/enhancer RT binding protein alpha message: transcriptional activator RT lacking antimitotic activity RL Proc. Natl. Acad. Sci. USA 90:9606-9610 (1993). RN [10] RA Lin F.-T., MacDougald O.A., Diehl A.M., Lane M.D. RT A 30-kDa alternative translation product of the CCAAT/enhancer RT binding protein alpha message: Transcriptional activator RT lacking antimitotic activity RL Proc. Natl. Acad. Sci. USA 90:9606-9610 (1993). RN [11] RA Legraverend C., Antonson P., Flodby P., Xanthopoulos K.G. RT High level activity of the mouse CCAAT/enhancer binding RT protein (C/EBP alpha) gene promoter involves autoregulation RT and several ubiquitous transcription factors RL Nucleic Acids Res. 21:1735-1742 (1993). RN [12] RA Metzger S., Leff T., Breslow J. L. RT Nuclear factors AF-1 and C/EBP bind to the human ApoB RT gene promoter and modulate its transcriptional activity in hepatic cells RL J. Biol. Chem. 265:9978-9983 (1990). RN [13] RA Kaestner K. H., Christy R. J., Lane M. D. RT Mouse insulin-responsive glucose transporter gene: RT Characterization of the gene and trans-activation RT by the CCAAT/enhancer binding protein RL Proc. Natl. Acad. Sci. USA 87:251-255 (1990). RN [14] RA Herrera R., Ro H. S., Robinson G. S., Xanthopoulos K. G., Spiegelman B. M. RT A Direct Role for C/EBP and the AP-I-Binding Site RT in Gene Expression Linked to Adipocyte Differentiation RL Mol. Cell. Biol. 9:5331-5339 (1989). RN [15] RA Christy R. J., Yang V. W., Ntambi J. M., Geiman D. RA E., Landschulz W. H., Friedman A. D., Nakabeppu Y., Kelly T. J., Lane M. D. RT Differentiation-induced gene expression in 3T3-L1 RT preadipocytes: CCAAT/ enhancer binding protein interacts RT with and activates the promoters of two adipocyte-specific genes RL Genes Dev. 3:1323-1335 (1989). RN [16] RA Montgomery K. T., Tardiff J. T., Reid L. M., Krauter K. S. RT Negative and Positive cis-Acting Elements Control RT the Expression of Murine alpha1-Protease Inhibitor Genes RL Mol. Cell. Biol. 10:2625-2637 (1990). RN [17] RA Christy R. J., Kaestner K. H., Geiman D. E., Lane M. D. RT CCAAT/enhancer binding protein gene promoter: binding RT of nuclear factors during differentiation of 3T3-L1 preadipocytes RL Proc. Natl. Acad. Sci. USA 88:2593-2597 (1991). RN [18] RA Xanthopoulos K. G., Mirkovitch J., Decker T., Kuo C. F., Darnell Jr. J. E. RT Cell-specific transcriptional control of the mouse RT DNA-binding protein mC/EBP RL Proc. Natl. Acad. Sci. USA 86:4117-4121 (1989). RN [19] RA Samuelsson L., Stroemberg K., Vikman K., Bjursell G., Enerbaeck S. RT The CCAAT/enhancer binding protein and its role in RT adipocyte differentiation: evidence for direct involvement RT in terminal adipocyte development RL EMBO J. 10:3787-3793 (1991). RN [20] RA Cao Z., Umek R. M., McKnight S. L. RT Regulated expression of three C/EBP isoforms during RT adipose conversion of 3T3-L1 cells RL Genes Dev. 5:1538-1552 (1991). RN [21] RA Park E. A., Roesler W. J., Liu J., Klemm D. J., Gurney RA A. L., Thatcher J. D., Shuman J., Friedman A., Hanson R. W. RT The role of the CCAAT/enhancer-binding protein in RT the transcriptional regulation of the gene for phosphoenolpyruvate RT carboxykinase (GTP) RL Mol. Cell. Biol. 10:6264-6272 (1990). XX // AC T00105 XX ID T00105 XX DT 15.10.92 (created); ewi. DT 26.02.97 (updated); ewi. XX FA C/EBPalpha XX SY BPc; C/EBP; CBP; EBP20; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0008; bZIP; 1.1.3.0.1.1. XX SZ 358 AA; 37.6 kDa (cDNA) XX SQ MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPPKPPAPPAAPEPLGGICEHET SQ SIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAVGPTGGGGGGDFDYPGAPAGPGGAVM SQ PGGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFP SQ YQPPPPPPPSHPHPHPPPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPA SQ LGAAGLPGPGSALKGLGAAHPDLRASGGTGAGKAKKSVDKNSNEYRVRRERNNIAVRKSR SQ DKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA XX SC SwissProt #P49715 XX FT 273 306 basic region FT 310 345 leucine zipper (TL5) XX IN T00017; C/EBPbeta; mouse, Mus musculus. IN T00105; C/EBPalpha; human, Homo sapiens. IN T00109; C/EBPdelta; rat, Rattus norvegicus. IN T00127; CHOP-10; mouse, Mus musculus. IN T00216; C/EBPgamma; mouse, Mus musculus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. IN T00581; C/EBPbeta; human, Homo sapiens. IN T00583; C/EBPdelta; human, Homo sapiens. IN T01114; C/EBPdelta; mouse, Mus musculus. IN T01303; CREB-2; human, Homo sapiens. XX MX M00116; V$CEBPA_01 MX M00159; V$CEBP_01 MX M00201; V$CEBP_C MX M00249; V$CHOP_01 XX BS R02132; CEBP$CONS_01; Quality: 2 BS R04246; CEBP$CONS_02; Quality: 6 BS R04247; CEBP$CONS_03; Quality: 6 BS R00631; HBV$HBVE_02; Quality: 1; HBV, human hepatitis B virus BS R00632; HBV$HBVE_03; Quality: 1; HBV, human hepatitis B virus BS R00637; HBV$HBVE_08; Quality: 1; HBV, human hepatitis B virus BS R00138; HS$APOA2_03; Quality: 4; human, Homo sapiens BS R03657; HS$APOB_06; Quality: 4; human, Homo sapiens BS R00239; HS$CRP_03; Quality: 2; human, Homo sapiens BS R00422; HS$FIX_02; Quality: 4; human, Homo sapiens BS R00125; MOUSE$A1ANTR_01; Quality: 2; mouse, Mus musculus BS R00127; MOUSE$A1ANTR_03; Quality: 2; mouse, Mus musculus BS R03730; RAT$SAA1_02; Quality: 4; rat, Rattus norvegicus BS R03732; RAT$SAA1_04; Quality: 4; rat, Rattus norvegicus BS R03733; RAT$SAA1_05; Quality: 4; rat, Rattus norvegicus XX DR EMBL: U34070; HS340701(g). DR SwissProt: P49715; CEBA_HUMAN. DR Compel: C00069 DR Compel: C00122 XX RN [1] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [2] RA Lucero M. A., Sanchez D., Ochoa A. R., Brunel F., RA Cohen G. N., Baralle F. E., Zakin M. M. RT Interaction of DNA-binding proteins with the tissue-specific RT human apolipoprotein-AII enhancer RL Nucleic Acids Res. 17:2283-2300 (1989). RN [3] RA Antonson P., Xanthopoulos K. G. RT Molecular cloning, sequence, and expression patterns RT of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBPalpha) RL Biochem. Biophys. Res. Commun. 215:106-113 (1995). XX // AC T00106 XX ID T00106 XX DT 24.03.93 (created); ewi. DT 04.03.97 (updated); ewi. XX FA C/EBP XX SY DmC/EBP; slbo; slow border cells; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0008; bZIP; 1.1.3.0.7. XX SZ 444 AA; 49 kDa (cDNA) XX SQ MLNMESPQMYADAVQTLAQLDLKKEPPLQQATIGQITLTAMSTAQQQQQQQQQQQQQQQQ SQ QQQQPQQQTTDANNNTSQDAALLVKQHAMHQMQQVAALGSNNNLLQKQMLQQYSTQTDLD SQ ELTTQEITLDLQHLIDDQFRDTETLGIFSDMVTSPGGLSATLRRANGLGGAKVLQQQTLR SQ NQHGYGGRGGGGGAGGALAYMPQPVHATYNNSSDENSSVGSDSSTIKEEPIDPEYRRHLQ SQ EAASQQAAFMGNGAGLYNGYGSGANGLTGGGNPLNGGNTTPSSNGSNGSTGSSNGSQFTN SQ LTTANVLAHHNLPQPGGRSRSTHVLKQHSKLHAQQQHQQHQQQQQHRKHSNKHVDKGTDE SQ YRRRRERNNIAVRKSREKAKVRSREVEERVKSLLKEKDALIRQLGEMTNELQLHKQIYMQ SQ LMNHANPEVSRVCRSFLNTNEHSL XX SC SwissProt #Q02637 XX FT 45 68 glutamine-rich region (23/24) FT 334 345 glutamine-rich region (10/12) FT 354 384 basic region FT 386 421 variant leucine-zipper (VL2MHL) XX CP late embryos: lining cell of gut and epidermis XX FF may be required for expression of gene products that FF mediate border cell migration [2]; FF deletion mutations cause late embryonic lethality, FF before or upon hatching [1]; FF appears to autoregulate its own gene [1]; XX IN T00106; C/EBP; fruit fly, Drosophila melanogaster. IN T00127; CHOP-10; mouse, Mus musculus. IN T00216; C/EBPgamma; mouse, Mus musculus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. XX DR EMBL: L00632; DMCEBPA(g). DR SwissProt: Q02637; CEB_DROME. DR PIR: A43481; A43481. DR Flybase: FBgn0005638; slbo. XX RN [1] RA Rorth P., Montell D. J. RT Drosophila C/EBP: a tissue-specific DNA-binding protein RT required for embryonic development RL Genes Dev. 6:2299-2311 (1992). RN [2] RA Montell D. J., Rorth P., Spradling A. C. RT slow border cells, a locus required for developmentally RT regulated cell migration during oogenesis , encodes Drosophila C/EBP RL Cell 71:51-62 (1992). XX // AC T00107 XX ID T00107 XX DT 15.10.92 (created); ewi. DT 26.02.97 (updated); ewi. XX FA C/EBPalpha XX SY BPc; C/EBP; CBP; EBP20; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX HO EFII XX CL C0008; bZIP; . XX SZ 324 AA; 35.7 kDa (cDNA), 42 kDa (SDS) [3]; XX SQ MEQANFYEVDSRPPMSSGQHHQLQTPLPGSAYGYREAPSAAAPAAGGAELGDICENEHSI SQ DISAYIDPAAFNDEFLADLFQHSKQQEKHKAVLAGDFDFHGMHGAGAAASAPGHHPQHQQ SQ QPLFGCAAGYMDGKLDPLYERIAAPGLRPLVIKQEPREEEEVKAAALAALYPHPQQHPSH SQ LQYQIAHCAQTTVHLQPGHPTPPPTPVPSPHHPHHPHPPGALPAAPGALKMMPADHRGKS SQ KKTVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTTDNERLRKRVEQLSRE SQ LETLRGIFRQLPESSLVKAMGSCA XX SC translated from EMBL # X66844 XX FT 239 272 basic region FT 276 311 leucine zipper (TL5) FT 15 15 alternative translation initiation codon [3]; FT 102 102 alternative translation initiation codon [3]; FT 231 231 alternative translation initiation codon [3]; XX SF use of internal translation initiation codons may SF be due to leaky ribosome scanning, giving rise to SF products of 40 kDa (Met-15), 29 kDa (Met-102) and 14 kDa (Met-231) [3]; XX IN T00127; CHOP-10; mouse, Mus musculus. IN T00216; C/EBPgamma; mouse, Mus musculus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. XX MX M00116; V$CEBPA_01 MX M00159; V$CEBP_01 MX M00249; V$CHOP_01 XX BS R02132; CEBP$CONS_01; Quality: 6 BS R04246; CEBP$CONS_02; Quality: 6 BS R04247; CEBP$CONS_03; Quality: 6 BS R00156; CHICK$APOVLDL_04; Quality: 4; chick, Gallus gallus BS R02598; CHICK$APOVLDL_06; Quality: 4; chick, Gallus gallus BS R02950; CHICK$APOVLDL_08; Quality: 4; chick, Gallus gallus BS R02583; CHICK$LYS_19; Quality: 1; chick, Gallus gallus BS R02584; CHICK$LYS_20; Quality: 1; chick, Gallus gallus BS R02585; CHICK$LYS_21; Quality: 1; chick, Gallus gallus BS R02587; CHICK$LYS_23; Quality: 1; chick, Gallus gallus BS R02588; CHICK$LYS_24; Quality: 1; chick, Gallus gallus BS R02589; CHICK$LYS_25; Quality: 1; chick, Gallus gallus BS R01581; CHICK$VIT2_14; Quality: 2; chick, Gallus gallus XX DR EMBL: X66844; GDCEBP(g). XX RN [1] RA Ryden T. A., Beemon K. RT Avian Retroviral Long Terminal Repeats Bind CCAAT/Enhancer-Binding Protein RL Mol. Cell. Biol. 9:1155-1164 (1989). RN [2] RA Calkhoven C.F., Ab G., Wijnholds J. RT cC/EPB, a chicken transcription factor of the leucine-zipper C/EPB family RL Nucleic Acids Res. 20:4093-4093 (1992). RN [3] RA Calkhoven C. F., Bouwman P. R. J., Snippe L., Ab G. RT Translation start site multiplicity of the CCAAT/enhancer RT binding protein alpha mRNA is dictated by a small 5' open reading frame RL Nucleic Acids Res. 22:5540-5547 (1994). RN [4] RA Seal S. N., Davis D. L., Burch J. B. E. RT Mutational studies reveal a complex set of positive RT and negative control elements within the chicken vitellogenin II promoter RL Mol. Cell. Biol. 11:2704-2717 (1991). RN [5] RA Park E. A., Roesler W. J., Liu J., Klemm D. J., Gurney RA A. L., Thatcher J. D., Shuman J., Friedman A., Hanson R. W. RT The role of the CCAAT/enhancer-binding protein in RT the transcriptional regulation of the gene for phosphoenolpyruvate RT carboxykinase (GTP) RL Mol. Cell. Biol. 10:6264-6272 (1990). XX // AC T00108 XX ID T00108 XX DT 15.10.92 (created); ewi. DT 26.02.97 (updated); ewi. XX FA C/EBPalpha XX SY BPc; C/EBP; CBP; EBP20; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.3.0.1.1. XX SZ 358 AA; 37.7 kDa (cDNA), 42 kDa (SDS) [2], [9]; XX SQ MESADFYEAEPRPPMSSHLQSPPHAPSNARLWLSPGRGPRAAPSPTCRPGAAGRICEHET SQ SIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAVMSA SQ GAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQ SQ PPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPAMGAA SQ GLPGPGGSLKGLAGPHPDLRTGGGGGGGAGAGKAKKSVDKNSNEYRVRRERNNIAVRKSR SQ DKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA XX SC SwissProt #P05554 XX FT 1 117 missing in p30(C/EBPalpha) [16]; FT 1 107 trans-activation domain FT 1 71 trans-activation element I (TE-I) FT 72 96 TE-II FT 107 170 attenuator domain [32]; FT 126 199 TE-III FT 126 155 negative regulatory subdomain in TE-III FT 128 257 weaker trans-activation domain, FT proline-rich (130/30) [29], [32]; FT 273 306 basic region FT 310 345 leucine zipper (TL5) FT 299 299 Ser-phosphorylation by PKC [10]; FT 15 15 alternative translation initiation codon [16]; FT 69 97 trans-activation domain, potential FT alpha-helix; region 3 [29]; FT 118 118 alternative translation initiation codon [16]; XX SF scissors-grip and helical-fork models for DNA-binding SF scissors grip: upon DNA-binding, the alpha-helices SF of the two leucine zippers extend towards the basic SF regions which make the DNA- contacts [15]; SF a kink has been postulated between basic subregions SF A and B at the conserved Asn-292, allowing to track SF the basic region in the major groove around the DNA double helix [15]; SF proteolytically sensitive sites between basic subregions SF A and B and between basic region and the leucine zipper [30]; SF helical-fork: similar to scissors-grip model, but SF the basic region forms an extended rather than a kinked alpha-helix [17]; SF highly relaxed DNA-binding specificity [40], [38]; SF Y285, N293, and V296 determine the DNA-binding specificity SF over that of GCN4 [7]; SF the "hinge region" at the end of the basic region SF and the beginning of the leucine zipper (303-317) SF defines the spatial relatoin between the half-sites SF of the bound DNA sequence [7]; SF the mid-regional trans-activating region consists of redundant modules [29]; SF the N-terminal part of the molecule exhibits antimitotic activity [16]; XX CP nonproliferating liver, adipose, small intestine,adrenal CP gland, placenta, lung, brain, skin [28]; low levels CP in muscle and thymus [37]; CN heart [28]; XX FF activator [21], [22]; FF required for and regulating the terminal adipocyte FF differentiation [21], [39], [13], thereby reciprocally FF regulated as and prevented by c-myc [33]; FF expressed only in fully differentiated cells [28]; FF decreased levels in regenerating liver [11]; FF repressor at the genomes of HBV, SV40 [15]; FF significant enhancement of dimerization by Tax [5]; FF phosphorylation at S299 attenuates DNA-binding [10]; XX IN T00017; C/EBPbeta; mouse, Mus musculus. IN T00051; ATF; human, Homo sapiens. IN T00108; C/EBPalpha; rat, Rattus norvegicus. IN T00109; C/EBPdelta; rat, Rattus norvegicus. IN T00127; CHOP-10; mouse, Mus musculus. IN T00171; C/EBPepsilon; rat, Rattus norvegicus. IN T00216; C/EBPgamma; mouse, Mus musculus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. IN T00581; C/EBPbeta; human, Homo sapiens. IN T01114; C/EBPdelta; mouse, Mus musculus. IN T01303; CREB-2; human, Homo sapiens. XX MX M00116; V$CEBPA_01 MX M00159; V$CEBP_01 MX M00201; V$CEBP_C MX M00249; V$CHOP_01 XX BS R03153; AD$E4_24; Quality: 2; adenovirus BS R00102; AMV$AMV_01; Quality: 5; AMV, avian myeloblastosis virus BS R00103; AMV$AMV_02; Quality: 5; AMV, avian myeloblastosis virus BS R00104; AMV$AMV_03; Quality: 5; AMV, avian myeloblastosis virus BS R03906; AS$ATF_04; Quality: 6 BS R00207; AS$CEBP_01; Quality: 2 BS R02132; CEBP$CONS_01; Quality: 1 BS R04246; CEBP$CONS_02; Quality: 6 BS R04247; CEBP$CONS_03; Quality: 6 BS R00480; FSV$FSV_01; Quality: 5; FSV, fujinami sarcoma virus BS R00631; HBV$HBVE_02; Quality: 2; HBV, human hepatitis B virus BS R00632; HBV$HBVE_03; Quality: 2; HBV, human hepatitis B virus BS R00635; HBV$HBVE_06; Quality: 2; HBV, human hepatitis B virus BS R00637; HBV$HBVE_08; Quality: 2; HBV, human hepatitis B virus BS R02056; HBV$HBVE_13; Quality: 2; HBV, human hepatitis B virus BS R02737; HBV$HBVE_15; Quality: 2; HBV, human hepatitis B virus BS R02739; HBV$HBVE_17; Quality: 2; HBV, human hepatitis B virus BS R02740; HBV$HBVE_18; Quality: 2; HBV, human hepatitis B virus BS R02743; HBV$HBVE_21; Quality: 2; HBV, human hepatitis B virus BS R02744; HBV$HBVE_22; Quality: 2; HBV, human hepatitis B virus BS R02745; HBV$HBVE_23; Quality: 2; HBV, human hepatitis B virus BS R02746; HBV$HBVE_24; Quality: 2; HBV, human hepatitis B virus BS R03246; HS$ADH1_02; Quality: 2; human, Homo sapiens BS R03250; HS$ADH1_06; Quality: 1; human, Homo sapiens BS R03251; HS$ADH1_07; Quality: 2; human, Homo sapiens BS R03252; HS$ADH1_08; Quality: 2; human, Homo sapiens BS R03128; HS$ADH2_03; Quality: 2; human, Homo sapiens BS R03129; HS$ADH2_04; Quality: 2; human, Homo sapiens BS R03130; HS$ADH2_05; Quality: 2; human, Homo sapiens BS R03131; HS$ADH2_06; Quality: 2; human, Homo sapiens BS R03234; HS$ADH2_07; Quality: 1; human, Homo sapiens BS R03237; HS$ADH3_03; Quality: 2; human, Homo sapiens BS R03239; HS$ADH3_05; Quality: 2; human, Homo sapiens BS R03242; HS$ADH3_08; Quality: 1; human, Homo sapiens BS R03243; HS$ADH3_09; Quality: 2; human, Homo sapiens BS R03244; HS$ADH3_10; Quality: 2; human, Homo sapiens BS R02459; HS$ALBU_06; Quality: 2; human, Homo sapiens BS R01613; HS$APOB_02; Quality: 1; human, Homo sapiens BS R02468; HS$CC3_01; Quality: 2; human, Homo sapiens BS R00422; HS$FIX_02; Quality: 2; human, Homo sapiens BS R00627; HS$HG_01; Quality: 2; human, Homo sapiens BS R00629; HS$HG_03; Quality: 2; human, Homo sapiens BS R03152; HS$HPX_01; Quality: 2; human, Homo sapiens BS R03068; HS$INSR_01; Quality: 2; human, Homo sapiens BS R03069; HS$INSR_02; Quality: 2; human, Homo sapiens BS R01456; HS$TF_07; Quality: 3; human, Homo sapiens BS R01445; HSV1$TK_04; Quality: 5; HSV-1, herpes simplex virus type 1 BS R00125; MOUSE$A1ANTR_01; Quality: 2; mouse, Mus musculus BS R02042; MOUSE$AFEP_11; Quality: 2; mouse, Mus musculus BS R02045; MOUSE$AFEP_14; Quality: 2; mouse, Mus musculus BS R02046; MOUSE$AFEP_15; Quality: 1; mouse, Mus musculus BS R02460; MOUSE$AGP_01; Quality: 3; mouse, Mus domesticus BS R02461; MOUSE$AGP_02; Quality: 3; mouse, Mus domesticus BS R00082; MOUSE$ALBU_01; Quality: 2; mouse, Mus musculus BS R00083; MOUSE$ALBU_02; Quality: 2; mouse, Mus musculus BS R00089; MOUSE$ALBU_08; Quality: 2; mouse, Mus musculus BS R00090; MOUSE$ALBU_09; Quality: 2; mouse, Mus musculus BS R00093; MOUSE$ALBU_11; Quality: 2; mouse, Mus musculus BS R01839; MOUSE$AP2_03; Quality: 2; mouse, Mus musculus BS R00837; MOUSE$IGH_03; Quality: 2; mouse, Mus musculus BS R00847; MOUSE$IGH_13; Quality: 2; mouse, Mus musculus BS R02457; MOUSE$SAA3_01; Quality: 2; mouse, Mus musculus BS R02458; MOUSE$SAA3_02; Quality: 2; mouse, Mus musculus BS R01841; MOUSE$SCD1_02; Quality: 2; mouse, Mus musculus BS R01463; MOUSE$TTPA_03; Quality: 2; mouse, Mus musculus BS R01154; MSV$MSV_02; Quality: 2; MSV, murine sarcoma virus BS R01156; MSV$MSV_04; Quality: 2; MSV, murine sarcoma virus BS R01235; PA$PY_17; Quality: 2; Py, polyoma virus BS R00111; RAT$ANTEN_01; Quality: 2; rat, Rattus norvegicus BS R03307; RAT$ARGL_01; Quality: 4; rat, Rattus norvegicus BS R03310; RAT$ARGL_04; Quality: 4; rat, Rattus norvegicus BS R02564; RAT$CPS1_01; Quality: 2; rat, Rattus norvegicus BS R01217; RAT$PEPCK_06; Quality: 1; rat, Rattus norvegicus BS R01686; RAT$PEPCK_11; Quality: 2; rat, Rattus norvegicus BS R01688; RAT$PEPCK_13; Quality: 2; rat, Rattus norvegicus BS R01689; RAT$PEPCK_14; Quality: 2; rat, Rattus norvegicus BS R01358; RAT$SSTA_01; Quality: 4; rat, Rattus norvegicus BS R03139; RAT$TAT_14; Quality: 2; rat, Rattus norvegicus BS R03141; RAT$TAT_16; Quality: 2; rat, Rattus norvegicus BS R03142; RAT$TAT_17; Quality: 2; rat, Rattus norvegicus BS R03143; RAT$TAT_18; Quality: 2; rat, Rattus norvegicus BS R03147; RAT$TAT_22; Quality: 2; rat, Rattus norvegicus BS R03148; RAT$TAT_23; Quality: 2; rat, Rattus norvegicus BS R03149; RAT$TAT_24; Quality: 2; rat, Rattus norvegicus BS R03151; RAT$TAT_26; Quality: 2; rat, Rattus norvegicus BS R01314; RAV0$RAV0_01; Quality: 5; RAV-0, rous-associated virus 0 BS R01344; RSV$RSV_04; Quality: 2; RSV, rous sarcoma virus BS R01408; SV$SV40_40; Quality: 2; SV40, simian virus 40 BS R02895; XENLA$VITA2_03; Quality: 2; clawed frog, Xenopus laevis XX DR EMBL: X12752; RNCEBP(g). DR SwissProt: P05554; CEBA_RAT. DR PIR: S06890; S06890. XX RN [1] RA Graves B. J., Johnson P. F., McKnight S. L. RT Homologous recognition of a promoter domain common RT to the MSV LTR and the HSV tk gene RL Cell 44:565-576 (1986). RN [2] RA Johnson P. F., Landschulz W. H., Graves B. J., McKnight S. L. RT Identification of a rat liver nuclear protein that RT binds to the enhancer core element of three animal viruses RL Genes Dev. 1:133-146 (1987). RN [3] RA Herbst R. S., Friedman N., Darnell J. E., Babiss L. E. RT Positive and negative regulatory elements in the mouse albumin enhancer RL Proc. Natl. Acad. Sci. USA 86:1553-1557 (1989). RN [4] RA Vinson C. R., Hai T., Boyd S. M. RT Dimerization specificity of the leucine zipper-containing RT bZIP motif on DNA binding: prediction and rational design RL Genes Dev. 7:1047-1058 (1993). RN [5] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [6] RA Nerlov C., Ziff E. B. RT Three levels of functional interaction determine the RT activity of CCAAT/enhancer binding protein-alpha on RT the serum albumin promoter RL Genes Dev. 8:350-362 (1994). RN [7] RA Johnson P. F. RT Identification of C/EBP basic region residues involved RT in DNA sequence recognition and half-site spacing preference RL Mol. Cell. Biol. 13:6919-6930 (1993). RN [8] RA Ryden T. A., Beemon K. RT Avian Retroviral Long Terminal Repeats Bind CCAAT/Enhancer-Binding Protein RL Mol. Cell. Biol. 9:1155-1164 (1989). RN [9] RA Landschulz W. H., Johnson P. F., Adashi E. Y., Graves B. J., McKnight S. L. RT Isolation of a recombinant copy of the gene encoding C/EBP RL Genes Dev. 2:786-800 (1988). RN [10] RA Mahoney C. W., Shuman J., McKnight S. L., Chen H. C., Huang K. P. RT Phosphorylation of CCAAT-enhancer binding protein RT by protein kinase C attenuates site-selective DNA binding RL J. Biol. Chem. 267:19396-19403 (1992). RN [11] RA Mischoulon D., Rana B., Bucher N. L. R., Farmer S. R. RT Growth-dependent inhibition of CCAAT/enhancer-binding RT protein (C/EBPalpha) gene expression during hepatocyte RT proliferation in the regenerating liver and in culture RL Mol. Cell. Biol. 12:2553-2560 (1992). RN [12] RA Legraverend C., Antonson P., Flodby P., Xanthopoulos K. G. RT High level activity of the mouse CCAAT/enhancer binding RT protein (C/EBPalpha) gene promoter involves autoregulation RT and several ubiquitous transcription factors RL Nucleic Acids Res. 21:1735- 1742 (1993). RN [13] RA Freytag S. O., Paielli D. L., Gilbert J. D. RT Ectopic expression of the CCAAT/enhancer-binding protein RT alpha promotes the adipogenic program in a variety RT of mouse fibroblastic cells RL Genes Dev. 8:1654-1663 (1994). RN [14] RA Lin F. -T., MacDougald O. A., Diehl A. M., Lane M. D. RT A 30-kDa alternative translation product of the CCAAT/enhancer RT binding protein alpha message: transcriptional activator RT lacking antimitotic activity RL Proc. Natl. Acad. Sci. USA 90:9606-9610 (1993). RN [15] RA Vinson C. R., Sigler P. B., McKnight S. L. RT Scissors-grip model for DNA recognition by a family RT of leucine zipper proteins RL Science 246:911-916 (1989). RN [16] RA Lin F.-T., MacDougald O.A., Diehl A.M., Lane M.D. RT A 30-kDa alternative translation product of the CCAAT/enhancer RT binding protein alpha message: Transcriptional activator RT lacking antimitotic activity RL Proc. Natl. Acad. Sci. USA 90:9606-9610 (1993). RN [17] RA ONeil K.T., Hoess R.H., DeGrado W.F. RT Design of DNA-binding Peptides Based on the Leucine Zipper Motif RL Science 249:774-778 (1990). RN [18] RA Dikstein R., Faktor O., Ben-Levy R., Shaul Y. RT Functional Organization of the Hepatitis B Virus Enhancer RL Mol. Cell. Biol. 10:3683-3689 (1990). RN [19] RA Trus M., Benvenisty N., Cohen H., Reshef L. RT Developmentally Regulated Interaction of Liver Nuclear RT Factors with the Rat Phosphoenolpyruvate Carboxykinase Promoter RL Mol. Cell. Biol. 10:2418-2422 (1990). RN [20] RA Stein B., Cogswell P. C., Baldwin A. S. RT Functional and physical associations between NF-kappaB RT and C/EBP family members: a Rel domain-bZIP interaction RL Mol. Cell. Biol. 13:3964-3974 (1993). RN [21] RA Christy R. J., Yang V. W., Ntambi J. M., Geiman D. RA E., Landschulz W. H., Friedman A. D., Nakabeppu Y., Kelly T. J., Lane M. D. RT Differentiation-induced gene expression in 3T3-L1 RT preadipocytes: CCAAT/ enhancer binding protein interacts RT with and activates the promoters of two adipocyte-specific genes RL Genes Dev. 3:1323-1335 (1989). RN [22] RA Friedman A. D., Landschulz W. H., McKnight S. L. RT CCAAT/enhancer binding protein activates the promoter RT of the serum albumin gene in cultured hepatoma cells RL Genes Dev. 3:1314-1322 (1989). RN [23] RA Ossipow V., Descombes P., Schibler U. RT CCAAT/enhancer-binding protein mRNA is translated RT into multiple proteins with different transcription activation potentials RL Proc. Natl. Acad. Sci. USA 90:8219-8223 (1993). RN [24] RA Howell B. W., Lagace M., Shore M. C. RT Activity of the Carbamyl Phosphate Synthetase I Promoter RT in Liver Nuclear Extracts is Dependent on a cis-Acting RT C/EBP Recognition Element RL Mol. Cell. Biol. 9:2928-2933 (1989). RN [25] RA Landschulz W. H., Johnson P. F., McKnight S. L. RT The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite RL Science 243:1681-1688 (1989). RN [26] RA McKeon C., Pham T. RT Transactivation of the human insulin receptor gene RT by the CAAT/enhancer binding protein RL Biochem. Biophys. Res. Commun. 174:721-728 (1991). RN [27] RA Trujillo M. A., Letovsky J., Maguire H. F., Lopez-Cabrera M., Siddiqui A. RT Functional analysis of a liver-specific enhancer of the hepatitis B virus RL Proc. Natl. Acad. Sci. USA 88:3797-3801 (1991). RN [28] RA Birkenmeier E. H., Gwynn B., Howard S., Jerry J., RA Gordon J. I., Landschulz W. H., McKnight S. L. RT Tissue-specific expression, developmental regulation, RT and genetic mapping of the gene encoding CCAAT/enhancer binding protein RL Genes Dev. 3:1146-1156 (1989). RN [29] RA Friedman A. D., McKnight S. L. RT Identification of two polypeptide segments of CCAAT/enhancer-binding RT protein required for transcriptional activation of the serum albumin gene RL Genes Dev. 4:1416-1426 (1990). RN [30] RA Shuman J. D., Vinson C. R., McKnight S. L. RT Evidence of changes in protease sensitivity and subunit RT exchange rate on DNA binding by C/EBP RL Science 249:771-774 (1990). RN [31] RA Samuelsson L., Stroemberg K., Vikman K., Bjursell G., Enerbaeck S. RT The CCAAT/enhancer binding protein and its role in RT adipocyte differentiation: evidence for direct involvement RT in terminal adipocyte development RL EMBO J. 10:3787-3793 (1991). RN [32] RA Pei D., Shih C. RT An attenuator domain is sandwiched by two distinct RT transactivation domains in the transcription factor C/EBP RL Mol. Cell. Biol. 11:1480-1487 (1991). RN [33] RA Freytag S. O., Geddes T. J. RT Reciprocal regulation of adipogenesis by Myc and C/EBPalpha RL Science 256:379-382 (1992). RN [34] RA Williams S. C., Cantwell C. A., Johnson P. F. RT A family of C/EBP-related proteins capable of forming RT covalently linked leucine zipper dimers in vitro RL Genes Dev. 5:1553-1567 (1991). RN [35] RA Stewart M. J., Shean M. L., Paeper B. W., Duester G. RT The role of CCAAT/enhancer-binding protein in the RT differential regulation of a family of human liver RT alcohol dehydrogenase genes RL J. Biol. Chem. 266:11594-11603 (1991). RN [36] RA Lopez-Cabrera M., Letovsky J., Hu K.-Q., Siddiqui A. RT Transcriptional factor C/EBP binds to and transactivates RT the enhancer element II of the hepatitis B virus RL Virology 183:825-829 (1991). RN [37] RA Poli V., Mancini F. P., Cortese R. RT IL-6DBP, a nuclear protein involved in interleukin-6 RT signal transduction, defines a new family of leucine RT zipper proteins related to C/EBP RL Cell 63:643-653 (1990). RN [38] RA Bakker O., Parker M. G. RT CAAT/enhancer binding protein is able to bind to ATF/CRE elements RL Nucleic Acids Res. 19:1213-1217 (1991). RN [39] RA Umek R. M., Friedman A. D., McKnight S. L. RT CCAAT-enhancer binding protein: a component of a differentiation switch RL Science 251:288-292 (1991). RN [40] RA Pei D., Shih C. RT Transcriptional activation and repression by cellular RT DNA-binding protein C/EBP RL J. Virol. 64:1517-1522 (1990). RN [41] RA McKnight S. L., Lane M. D., Gluecksohn-Waelsch S. RT Is CCAAT/enhancer-binding protein a central regulator of energy metabolism RL Genes Dev. 3:2021-2024 (1989). RN [42] RA Zhang D.-E., Hoyt P. R., Papaconstantinou J. RT Localization of DNA Protein-binding Sites in the Proximal RT and Distal Promoter Regions of the Mouse alpha-Fetoprotein Gene RL J. Biol. Chem. 265:3382-3391 (1990). XX // AC T00109 XX ID T00109 XX DT 24.03.93 (created); ewi. DT 04.03.97 (updated); ewi. XX FA C/EBPdelta XX SY CELF; CRP3; NF-IL6beta; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.3.0.4. XX SZ 268 AA; 28.6 kDa (cDNA) XX SQ MSAALFSLDSPARGAPWPTEPAAFYEPGRVGKPGRGPEPGDLGEPGSTTPAMYDDESAID SQ FSAYIDSMAAVPTLELCHDEIFADLFNSNHKAAGAGSLELLQGGPTRPPGVGSIARGPLK SQ REPDWGDGDAPGSLLPAQVAVCAQTVVSLAAAAQPTPPTSPEPPRGSPGPSLAPGPVREK SQ GAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQL SQ TRDLASLRQFFKELPSPPFLPPTGTDCR XX SC translated from EMBL #M65149 XX FT 184 215 basic region FT 219 254 leucine zipper (ML5) XX SF same DNA-binding specificity as C/EBPbeta / NF-IL6 XX CP ubiquitous; abundant in testis and adrenal [1]; XX IN T00017; C/EBPbeta; mouse, Mus musculus. IN T00104; C/EBPalpha; mouse, Mus musculus. IN T00105; C/EBPalpha; human, Homo sapiens. IN T00108; C/EBPalpha; rat, Rattus norvegicus. IN T00109; C/EBPdelta; rat, Rattus norvegicus. IN T00171; C/EBPepsilon; rat, Rattus norvegicus. IN T00216; C/EBPgamma; mouse, Mus musculus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. IN T00581; C/EBPbeta; human, Homo sapiens. XX BS R04044; BOVIN$PPTA_01; Quality: 2; cattle, Bos taurus XX DR EMBL: M65149; RNCELF(r). DR SwissProt: Q03484; CEBD_RAT. DR PIR: B39429; B39429. XX RN [1] RA Kageyama R., Sasai Y., Nakanishi S. RT Molecular characterization of transcription factors RT that bind to the cAMP responsive region of the substance P precursor gene RL J. Biol. Chem. 266:15525-15531 (1991). RN [2] RA Williams S. C., Cantwell C. A., Johnson P. F. RT A family of C/EBP-related proteins capable of forming RT covalently linked leucine zipper dimers in vitro RL Genes Dev. 5:1553-1567 (1991). XX // AC T00110 XX ID T00110 XX DT 21.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CeMyoD XX SY Hlh-1; XX OS Caenorhabditis elegans OC eukaryota; animalia; eumetazoa; nematoda; secernentea; OC rhabditia; rhabditida; rhabditina; rhabditoidea; rhabditidae XX CL C0010; bHLH; 1.2.2.0.6. XX SZ 324 AA; 36.5 kDa (cDNA), 60 kDa (SDS) XX SQ MNTETSTQSAPSDTYDTSIYYNSSPRVTANDITTLTSFAAPAPQVLDYANTQYDIYRNQP SQ AYYLPSYAPTAPTTFYSDFANFNVTRSQDFASVPAVANSSDVKPIIIKQEKSTPNATELI SQ IQSRVDSQHEDTTTSTAGGAGVGGPRRTKFVLSVDRRKAATMRERRRLRKVNEAFEVVKQ SQ RTCPNPNQRLPKVEILRSAIDYINNLERMLQQAGKMTKIMEQNQHLQMTQQINGAPPHDY SQ VTSSHFASSSYNPENMFDDDDKTDSDDDRDHHKLGNAVDLRRRNSLDRLSRIVASIPNEE SQ AMTDEQLLQPANDVIDGEKKLEML XX SC SwissProt #P22980 XX FT 156 167 basic region FT 168 207 helix-loop-helix domain XX CP body wall muscle cells XX FF body wall muscle cell determinator; FF accumulates in body wall muscle cell precursors even FF before clonal commitment of these cells [2]; FF disruption of CeMyoD gene does not preclude body wall muscle formation [1]; XX DR EMBL: M59940; CEMYOD(g). DR SwissProt: P22980; MYOD_CAEEL. DR PIR: A36289; A36289. DR PIR: B36289; B36289. XX RN [1] RA Chen L., Krause M., Draper B., Weintraub H., Fire A. RT Body-wall muscle formation in Caenorhabditis elegans RT embryos that lack the MyoD homolog hlh-1 RL Science 256:240-243 (1992). RN [2] RA Krause M., Fire A., Harrison S. W., Priess J., Weintraub H. RT CeMyoD accumulation defines the body wall muscle cell RT fate during C. elegans embryogenesis RL Cell 63:907-919 (1990). XX // AC T00111 XX ID T00111 XX DT 27.10.92 (created); ewi. DT 21.05.97 (updated); ewi. XX FA c-Ets-1 XX SY Ets1; p54; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0016; ETS; 3.5.2.0.1.1. XX SZ 440 AA; 50.3 kDa (cDNA), 66 kDa (SDS) XX SQ MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQ SQ QRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMSGAALCALGKECFLELAPDF SQ VGDILWEHLEILQKEDVKPYQVNGANPTYPESCYTSDYFISYGIEHAQCVPPSEFSEPSF SQ ITESYQTLHPISSEELLSLKYENDYPSVILQDPLQTDTLQTDYFAIKQEVLTPDNMCLGR SQ ASRGKLGGQDSFESVESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDYEDYPAALPNHKP SQ KGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDG SQ WEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQS SQ LLGYTPEELHAMLDVKPDAD XX SC SwissProt #P27577 XX FT 68 134 POINTED domain of homology [6]; FT 170 322 repression of DNA-binding FT 331 415 ets-domain FT 338 375 tryptophan cluster (W-X17-W-X18-W) FT 423 440 repression of DNA-binding [2]; XX SF monomeric DNA-binding, spanning about 20 nucleotides SF of one face of the DNA double helix [3], [2]; SF major groove contacts within the contact core region, SF minor groove binding in the flanking sequences [3]; SF may be part of complex arrays of factor binding sites, SF e. g. along with PEBP2alpha, ATF/CREB and LEF-1 on the TCRalpha gene [4]; SF phosphorylation (Ca-dependent) [8]; XX CP T-cells (predom.); lymphoid cells: thymocytes, bursal CP lymphocytes [5]; neonatal mice: also in brain [5]; XX FF may play an important role in mesodermal cell development FF for organ formation and tissue modeling [5]; FF mitogenic stimuli cause Ca-dependent phosphorylation [8]; XX MX M00032; V$CETS1P54_01 XX BS R04053; AS$ETS1_04; Quality: 6 BS R04054; AS$ETS1_05; Quality: 6 BS R04055; AS$ETS1_06; Quality: 6 BS R04056; AS$ETS1_07; Quality: 6 BS R04057; AS$ETS1_08; Quality: 6 BS R04058; AS$ETS1_09; Quality: 6 BS R04059; AS$ETS1_10; Quality: 6 BS R04060; AS$ETS1_11; Quality: 6 BS R04061; AS$ETS1_12; Quality: 6 BS R04062; AS$ETS1_13; Quality: 6 BS R04063; AS$ETS1_14; Quality: 6 BS R02153; ETS1$CONS; Quality: 1 BS R03475; MOUSE$MB1_01; Quality: 4; mouse, Mus musculus BS R01155; MSV$MSV_03; Quality: 2; MSV, murine sarcoma virus BS R01156; MSV$MSV_04; Quality: 2; MSV, murine sarcoma virus BS R01224; PA$PY_06; Quality: 3; Py, polyoma virus XX DR EMBL: X55787; MMCETS1(r). DR EMBL: X53953; MMETS1(r). DR EMBL: M58482; MMETS1Q(r). DR SwissProt: P27577; ETS1_MOUSE. DR Compel: C00134 XX RN [1] RA Major E. O., Ameniya K., Elder G., Houff S. A. RT Glial cells of the human developing brain and B cells RT of the immune system share a common DNA binding factor RT for recognition of the regulatroy sequences of the human polyomavirus, JCV RL J. Neurosci. Res. 27:461-471 (1990). RN [2] RA Hagman J., Grosschedl R. RT An inhibitory carboxyl-terminal domain in Ets-1 and RT Ets-2 mediates differential binding of Ets family RT factors to promoter sequences of the mb-1 gene RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992). RN [3] RA Nye J. A., Petersen J. M., Gunther C. V., Jonsen M. D., Graves B. J. RT Interaction of murine Ets-1 with GGA-binding sites RT establishes the Ets domain as a new DNA-binding motif RL Genes Dev. 6:975-990 (1992). RN [4] RA Giese K., Kingsley C., Kirshner J. R., Grosschedl R. RT Assembly and function of a TCRalpha enhancer complex RT is dependent on LEF-1-induced DNA bending and multiple RT protein-protein interactions RL Genes Dev. 9:995-1008 (1995). RN [5] RA Kola I., Brookes S., Green A. R., Garber R., Tymms M., Papas T. S., Setz A. RT The Ets1 transcription factor is widely expressed RT during murine embryo development and is associated RT with mesodermal cells involved in morphogenetic processes RT such as organ formation RL Proc. Natl. Acad. Sci. USA 90:7588-7592 (1993). RN [6] RA Klaembt C. RT The Drosophila gene pointed encodes two ETS-like proteins RT which are involved in the development of the midline glial cells RL Development 117:163-176 (1993). RN [7] RA Chen J. H. RT Cloning, sequencing, and expression of mouse c-ets-1 RT cDNA in baculovirus expression system RL Oncogene Res. 5:277-285 (1990). RN [8] RA Pognonec P., Boulukos K. E., Gesquiere J. C., Stehelin D., Ghysdael J. RT Mitogenic stimulation of thymocytes results in the RT calcium-dependent phosphorylation of c-ets-1 proteins RL EMBO J. 7:977-983 (1988). XX // AC T00112 XX ID T00112 XX DT 26.10.92 (created); ewi. DT 19.06.97 (updated); ewi. XX FA c-Ets-1 XX SY Ets1; c-Ets-1 54; c-Ets-1A; p54; p54c-Ets-1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0016; ETS; 3.5.2.0.1.1. XX SZ 441 AA; 50.4 kDa (cDNA), 60 kDa, 55 kDa XX SQ MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQ SQ QRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKDCFLELAPDF SQ VGDILWEHLEILQKEDVKPYQVNGVNPAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSF SQ ITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQNDYFAIKQEVVTPDNMCMGR SQ TSRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKP SQ KGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDG SQ WEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQS SQ LLGYTPEELHAMLDVKPDADE XX SC SwissProt #P14921 XX FT 244 330 missing in c-Ets-1DeltaVII [8], [3]; FT 338 375 tryptophan cluster (W-X17-W-X18-W) XX SF alternative splice variants: c-Ets-1DeltaVII (lacking SF sequences encoded by exon VII) , c-Ets-1Delta SF IV (lacking exon IV) or variant that lacks both regions [8], [7]; SF phosphorylation (Ca-dependent) SF isoform of 48 kDa may be due to SH-modification [4]; XX CP T-cells (predom.) XX FF high levels in resting T cells, decreases after T-cell induction [10]; XX BS R02153; ETS1$CONS; Quality: 6 BS R02098; HS$TCRA_01; Quality: 1; human, Homo sapiens BS R01224; PA$PY_06; Quality: 3; Py, polyoma virus XX DR EMBL: X14798; HSCETS1(r). DR EMBL: J04101; HSETS1A(r). DR EMBL: X55346; HSPROM(g). DR SwissProt: P14921; ETS1_HUMAN. DR PIR: S10086; S10086. DR PIR: A32066; TVHUET. DR Compel: C00007 DR Compel: C00082 DR Compel: C00083 DR Compel: C00084 DR Compel: C00085 DR Compel: C00135 DR Compel: C00137 XX RN [1] RA Major E. O., Ameniya K., Elder G., Houff S. A. RT Glial cells of the human developing brain and B cells RT of the immune system share a common DNA binding factor RT for recognition of the regulatroy sequences of the human polyomavirus, JCV RL J. Neurosci. Res. 27:461-471 (1990). RN [2] RA Gunther C. V., Nye J. A., Bryner R. S., Graves B. J. RT Sequence-specific DNA binding of the proto-oncoprotein RT ets-1 defines a transcriptional activator sequence RT within the long terminal repeat of the Moloney murine sarcoma virus RL Genes Dev. 4:667-679 (1990). RN [3] RA Wasylyk C., Kerckaert J.-P., Wasylyk B. RT A novel modulator domain of Ets transcription factors RL Genes Dev. 6:965-974 (1992). RN [4] RA Fisher R. J., Koizumi S., Kondoh A., Mariano J. M., RA Mavrothalassitis G., Bhat N. K., Papas T. S. RT Human Ets1 oncoprotein RL J. Biol. Chem. 267:17957-17965 (1992). RN [5] RA Watson D. K., McWilliams-Smith M. J., Nunn M. F., RA Duesberg P. H., OBrien S. J., Papas T. S. RT The ets sequence from the transforming gene of avian erythroblastosis virus RL Proc. Natl. Acad. Sci. USA 82:7294-7298 (1985). RN [6] RA Watson D. K., McWilliams-Smith M. J., Lapis P., Lautenberger RA J. A., Schweinfest C. W., Papas T. S. RT Mammalian ets-1 and ets-2 genes encode highly conserved proteins RL Proc. Natl. Acad. Sci. USA 85:7862-7866 (1988). RN [7] RA Jorcyk C. L., Watson D. K., Mavrothalassitis G. J., Papas T. S. RT The human ETS1 gene: genomic structure, promoter characterization RT and alternative splicing RL Oncogene 6:523-532 (1991). RN [8] RA Reddy E. S. P., Rao V. N. RT Structure, expression and alternative splicing of RT the human c-ets-1 proto-oncogene RL Oncogene 3:239-246 (1988). RN [9] RA Ho I.-C., Bhat N. K., Gottschalk L. R., Lindsten R., RA Thompson C. B., Papas T. S., Leiden J. M. RT Sequence-specific binding of human Ets-1 to the T RT cell receptor alpha gene enhancer RL Science 250:814-818 (1990). RN [10] RA Bhat N. K., Thompson C. B., Lindsten T., June C. H., RA Fujiware S., Koizumi S., Fischer R. J., Papas T. S. RT Reciprocal expression of human ETS1 and ETS2 genes RT during T-cell activation: Regulatory role for the protooncogene ETS1 RL Proc. Natl. Acad. Sci. USA 87:3723-3727 (1990). RN [11] RA Ho I.-C., Bhat N., Gottschalk L. R., Lindstein T., RA Thompson C. B., Papas T. S., Leiden J. M. RT Sequence-specific binding of human Ets-1 to the T RT cell receptor alpha gene enhancer RL Science 250:814-818 (1990). RN [12] RA Pognonec P., Boulukos K. E., Gesquiere J. C., Stehelin D., Ghysdael J. RT Mitogenic stimulation of thymocytes results in the RT calcium-dependent phosphorylation of c-ets-1 proteins RL EMBO J. 7:977-983 (1988). RN [13] RA Bhat N. K., Thompson C. B., Lindstein T., June C. RA H., Fujiwara S., Koizumi S., Fisher R. J., Papas T. S. RT Reciprocal expression of human ETS1 and ETS2 genes RT during T-cell activation: Regulatory role for the protooncogene ETS1 RL Proc. Natl. Acad. Sci. USA 87:3723-3727 (1990). XX // AC T00113 XX ID T00113 XX DT 26.10.92 (created); ewi. DT 19.02.97 (updated); ewi. XX FA c-Ets-2 XX SY Ets-2; Ets2; c-Ets-2 58-64; p58-64c-Ets-2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0016; ETS; 3.5.2.0.2. XX SZ 469 AA; 53 kDa (cDNA), 56 kDa (SDS) XX SQ MNDFGIKNMDQVAPVANSYRGTLKRQPAFDTFDGSLFAVFPSLNEEQTLQEVPTGLDSIS SQ HDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATN SQ EFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEE SQ NSHLTSVPHWINSNTLGFGTEQAPYGMQTQNYPKGGLLDSMCPASTPSVLSSEQEFQMFP SQ KSRLSSVSVTYCSVSQDFPGSNLNLLTNNSGTPKDHDSPENGADSFESSDSLLQSWNSQS SQ SLLDVQRVPSFESFEDDCSQSLCLNKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGS SQ GPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRG SQ LRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED XX SC SwissProt #P15036 XX FT 102 168 POINTED domain of homology [5]; FT 454 469 repression of DNA-binding [1]; FT 66 167 Ets-1-homologous region FT 285 310 auxiliary for repression of DNA-binding [2]; FT 311 364 repression of DNA-binding [2]; FT 366 403 tryptophan cluster (W-X17-W-X18-W) FT 370 452 ETS-domain XX CP predominant expression in T cells XX FF increases after T-cell induction XX BS R02100; CHICK$MIM1_04; Quality: 1; chick, Gallus gallus BS R04338; HS$CDC2_01; Quality: 2; human, Homo sapiens BS R04339; HS$CDC2_02; Quality: 2; human, Homo sapiens BS R04343; HS$CDC2_06; Quality: 2; human, Homo sapiens BS R04350; HS$CYCD1_03; Quality: 6; human, Homo sapiens BS R01224; PA$PY_06; Quality: 3; Py, polyoma virus XX DR EMBL: X55181; HSETS23(r). DR EMBL: J04102; HSETS2A(r). DR SwissProt: P15036; ETS2_HUMAN. DR PIR: B32066; TVHUE2. DR Compel: C00020 DR Compel: C00079 DR Compel: C00080 DR Compel: C00082 DR Compel: C00083 DR Compel: C00084 DR Compel: C00085 DR Compel: C00135 XX RN [1] RA Hagman J., Grosschedl R. RT An inhibitory carboxyl-terminal domain in Ets-1 and RT Ets-2 mediates differential binding of Ets family RT factors to promoter sequences of the mb-1 gene RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992). RN [2] RA Wasylyk C., Kerckaert J.-P., Wasylyk B. RT A novel modulator domain of Ets transcription factors RL Genes Dev. 6:965-974 (1992). RN [3] RA Watson D. K., McWilliams-Smith M. J., Nunn M. F., RA Duesberg P. H., OBrien S. J., Papas T. S. RT The ets sequence from the transforming gene of avian erythroblastosis virus RL Proc. Natl. Acad. Sci. USA 82:7294-7298 (1985). RN [4] RA Watson D. K., McWilliams-Smith M. J., Lapis P., Lautenberger RA J. A., Schweinfest C. W., Papas T. S. RT Mammalian ets-1 and ets-2 genes encode highly conserved proteins RL Proc. Natl. Acad. Sci. USA 85:7862-7866 (1988). RN [5] RA Klaembt C. RT The Drosophila gene pointed encodes two ETS-like proteins RT which are involved in the development of the midline glial cells RL Development 117:163-176 (1993). RN [6] RA Bhat N. K., Thompson C. B., Lindsten T., June C. H., RA Fujiware S., Koizumi S., Fischer R. J., Papas T. S. RT Reciprocal expression of human ETS1 and ETS2 genes RT during T-cell activation: Regulatory role for the protooncogene ETS1 RL Proc. Natl. Acad. Sci. USA 87:3723-3727 (1990). RN [7] RA Bosselut R., Duvall J. F., Gegonne A., Bailly M., RA Hemar A., Brady J., Ghysdael J. RT The product of the c-ets-1 proto-oncogene and the RT related Ets2 protein act as transcriptional activators RT of the long terminal repeat of human T cell leukemia virus HTLV-1 RL EMBO J. 9:3137-3144 (1990). RN [8] RA Bhat N. K., Thompson C. B., Lindstein T., June C. RA H., Fujiwara S., Koizumi S., Fisher R. J., Papas T. S. RT Reciprocal expression of human ETS1 and ETS2 genes RT during T-cell activation: Regulatory role for the protooncogene ETS1 RL Proc. Natl. Acad. Sci. USA 87:3723-3727 (1990). RN [9] RA Dudek H., Tantravahi R. V., Rao V. N., Reddy E. Sh., Reddy E. P. RT Myb and Ets proteins cooperate in transcriptional RT activation of the mim-1 promoter RL Proc. Natl. Acad. Sci. USA 89:1291-1295 (1992). XX // AC T00114 XX ID T00114 XX DT 26.10.92 (created); ewi. DT 21.05.97 (updated); ewi. XX FA c-Ets-1 54 XX SY Ets1; c-Ets-1; p54; p54c-Ets-1; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0016; ETS; 3.5.2.0.1.1. XX SZ 441 AA; 50.4 kDa (cDNA), 54 kDa (SDS) XX SQ MKAAVDLKPTLTIIKTEKVDIDLFPSPDMECADVPLLTPSSKEMMSQALKATFSGFAKEQ SQ QRLGIPKDPQQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKECFLELRPDF SQ VGDILWEHLEILQKEEAKPYPANGVNAAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSF SQ ITESYQTLHPISSEELLSLKYENDYPSVILRDPVQTDSLQTDYFTIKQEVVTPDNMCMGR SQ ASRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFQSLQRVPSYDSFDSEDYPAALPNHKP SQ KGTFKDYVRDRADMNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDG SQ WEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQS SQ LLGYTPEELHAMLDVKPDADE XX SC SwissProt #P13474 XX FT 1 27 p54-specific N-terminus FT 68 134 POINTED domain of homology [5]; FT 170 322 repression of DNA-binding FT 331 415 ETS domain FT 423 440 repression of DNA-binding (by homology) [1]; FT 131 242 c-Ets1-specific trans-activation domain [2]; FT 338 375 tryptophan cluster (W-X17-W-X18-W) XX SF negative net charge (-10) of the trans-activation domain [2]; SF phosphorylation (Ca-dependent) [10]; XX CP T-cells (predom.); lymphoid cells [4]: thymocytes, bursal lymphocytes [4]; CN low in bone marrow, erythroblasts, fibroblasts, macrophages [4]; XX FF activator; FF functional cooperation with AP-1 [8], [7] and Sp1 [3]; FF in some cases, repression of AP-1 effects have been FF reported as well which depends on the C-terminal repressing domain [6]; XX MX M00032; V$CETS1P54_01 MX M00074; V$CETS1P54_02 XX BS R02153; ETS1$CONS; Quality: 6 BS R02232; PEA3$CONS; Quality: 6 XX DR EMBL: X13026; GGCETS(r). DR EMBL: M22462; GGETS1(r). DR EMBL: X13027; GGETSC(r). DR SwissProt: P13474; ETSA_CHICK. DR PIR: S07625; S07625. DR PIR: A31285; TVCHTE. DR Compel: C00020 DR Compel: C00131 XX RN [1] RA Hagman J., Grosschedl R. RT An inhibitory carboxyl-terminal domain in Ets-1 and RT Ets-2 mediates differential binding of Ets family RT factors to promoter sequences of the mb-1 gene RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992). RN [2] RA Gegonne A., Punyammalee B., Rabault B., Bosselut R., RA Seneca S., Crabeel M., Ghysdael J. RT Analysis of the DNA binding and transcriptional activation RT properties of the Ets1 oncoprotein RL New Biologist 4:512-519 (1992). RN [3] RA Gegonne A., Bosselut R., Bailly R.-A., Ghysdael J. RT Synergistic activation of the HTLV1 LTR Ets-responsive RT region by transcription factors Ets1 and Sp1 RL EMBO J. 12:1169-1178 (1993). RN [4] RA Ghysdael J., Gegonne A., Pognonec P., Dernis D., Leprince D., Stehelin D. RT Identification and preferential expression in thymic RT and bursal lymphocytes of a c-ets oncogene encoded RT Mr 54,000 cytoplasmic protein RL Proc. Natl. Acad. Sci. USA 83:1714-1718 (1986). RN [5] RA Klaembt C. RT The Drosophila gene pointed encodes two ETS-like proteins RT which are involved in the development of the midline glial cells RL Development 117:163-176 (1993). RN [6] RA Goldberg Y., Treier M., Ghysdael J., Bohmann D. RT Repression of AP-1 stimulated transcription by c-Ets-1 RL J. Biol. Chem. 269:16566-16573 (1994). RN [7] RA Wasylyk C., Gutman A., Nicholson R., Wasylyk B. RT The c-Ets oncoprotein activates the stromelysin promoter RT through the same elements as several non-nuclear oncoproteins RL EMBO J. 10:1127-1134 (1991). RN [8] RA Wasylyk B., Wasylyk C., Flores P., Begue A., Leprince D., Stehelin D. RT The c-ets proto-oncogenes encode transcription factors RT that cooperate with c-Fos and c-Jun for transcriptional activation RL Nature 346:191-193 (1990). RN [9] RA Wasylyk C., Gutman A., Nicholson R., Wasylyk B. RT The c-Ets oncoprotein activates the stromelysin promoter RT through the same elements as several non-nuclear oncoproteins RL EMBO J. 10:1127-1134 (1991). RN [10] RA Pognonec P., Boulukos K. E., Gesquiere J. C., Stehelin D., Ghysdael J. RT Mitogenic stimulation of thymocytes results in the RT calcium-dependent phosphorylation of c-ets-1 proteins RL EMBO J. 7:977-983 (1988). XX // AC T00115 XX ID T00115 XX DT 26.10.92 (created); ewi. DT 21.05.97 (updated); ewi. XX FA c-Ets-1 68 XX SY p68c-Ets-1; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0016; ETS; 3.5.2.0.1.2. XX SZ 485 AA; 55.0 kDa (cDNA), 68 kDa (SDS) XX SQ MMSYYMDTTIGSTGPYPLARPGVMQGASSCCEDPWMPCRLQSACCPPRSCCPPWDEAAIQ SQ EVPTGLEHYSTDMECADVPLLTPSSKEMMSQALKATFSGFAKEQQRLGIPKDPQQWTETH SQ VRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKECFLELAPDFVGDILWEHLEILQKEE SQ AKPYPANGVNAAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEEL SQ LSLKYENDYPSVILRDPVQTDSLQTDYFTIKQEVVTPDNMCMGRASRGKLGGQDSFESIE SQ SYDSCDRLTQSWSSQSSFQSLQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADMNK SQ DKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWG SQ KRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVK SQ PDADE XX SC SwissProt #P15062 XX FT 1 71 p68-specific N-terminus FT 375 459 ETS domain FT 312 350 repression of DNA-binding [2]; FT 377 477 minimal DNA-binding region FT 382 419 tryptophan cluster (W-X17-W-X18-W) XX SF alternative splice variant: c-Ets-1 54, differing in the N-termini SF in addition to the mid-regional represing domain, SF the C-terminal part of the molecule also inhibits DNA-binding [3]; SF phosphorylation (Ca-dependent) [10]; XX CP T-cells (predom.); thymocytes, bursal lymphocytes [5]; XX FF activator [7], [6], [9]; FF stronger activator than p54 splice variant [6]; FF functional cooperation with AP-1 at some promoters [7], [6]; FF levels decrease after T cell induction; FF association with MafB causes inhibition of FF erythroid differentiation [4]; XX BS R02386; DROME$E74_09; Quality: 6; fruit fly, Drosophila melanogaster BS R02153; ETS1$CONS; Quality: 6 BS R01711; HS$GP2B_06; Quality: 6; human, Homo sapiens BS R02414; HS$TCRBL_03; Quality: 2; human, Homo sapiens BS R02415; HS$TCRBL_04; Quality: 2; human, Homo sapiens BS R02099; HT1$HTLV1_08; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R04065; MOUSE$IGH_58; Quality: 6; mouse, Mus musculus BS R01155; MSV$MSV_03; Quality: 6; MSV, murine sarcoma virus BS R02232; PEA3$CONS; Quality: 6 BS R02097; RAT$TS_02; Quality: 6; rat, Rattus norvegicus XX DR EMBL: M20514; GGCETS02(g). DR EMBL: M20513; GGCETS10(g). DR EMBL: M20515; GGCETS11(g). DR EMBL: M20507; GGCETSS2(g). DR EMBL: M20508; GGCETSS3(g). DR EMBL: M20509; GGCETSS4(g). DR EMBL: M20510; GGCETSS6(g). DR EMBL: M20511; GGCETSS7(g). DR EMBL: M20512; GGCETSS8(g). DR EMBL: M29515; GGCETSS9(g). DR SwissProt: P15062; ETSB_CHICK. DR PIR: A28875; TVCHET. XX RN [1] RA Gunther C. V., Nye J. A., Bryner R. S., Graves B. J. RT Sequence-specific DNA binding of the proto-oncoprotein RT ets-1 defines a transcriptional activator sequence RT within the long terminal repeat of the Moloney murine sarcoma virus RL Genes Dev. 4:667-679 (1990). RN [2] RA Wasylyk C., Kerckaert J.-P., Wasylyk B. RT A novel modulator domain of Ets transcription factors RL Genes Dev. 6:965-974 (1992). RN [3] RA Lim F., Kraut N., Frampton J., Graf T. RT DNA binding by c-Ets-1, but not v-Ets, is repressed RT by an intramolecular mechanism RL EMBO J. 11:643-652 (1992). RN [4] RA Sieweke M. H., Tekotte H., Frampton J., Graf T. RT MafB is an interaction partner and repressor of Ets-1 RT that inhibits erythroid differentiation RL Cell 85:49-60 (1996). RN [5] RA Ghysdael J., Gegonne A., Pognonec P., Dernis D., Leprince D., Stehelin D. RT Identification and preferential expression in thymic RT and bursal lymphocytes of a c-ets oncogene encoded RT Mr 54,000 cytoplasmic protein RL Proc. Natl. Acad. Sci. USA 83:1714-1718 (1986). RN [6] RA Wasylyk C., Gutman A., Nicholson R., Wasylyk B. RT The c-Ets oncoprotein activates the stromelysin promoter RT through the same elements as several non-nuclear oncoproteins RL EMBO J. 10:1127-1134 (1991). RN [7] RA Wasylyk B., Wasylyk C., Flores P., Begue A., Leprince D., Stehelin D. RT The c-ets proto-oncogenes encode transcription factors RT that cooperate with c-Fos and c-Jun for transcriptional activation RL Nature 346:191-193 (1990). RN [8] RA Wasylyk C., Gutman A., Nicholson R., Wasylyk B. RT The c-Ets oncoprotein activates the stromelysin promoter RT through the same elements as several non-nuclear oncoproteins RL EMBO J. 10:1127-1134 (1991). RN [9] RA Bosselut R., Duvall J. F., Gegonne A., Bailly M., RA Hemar A., Brady J., Ghysdael J. RT The product of the c-ets-1 proto-oncogene and the RT related Ets2 protein act as transcriptional activators RT of the long terminal repeat of human T cell leukemia virus HTLV-1 RL EMBO J. 9:3137-3144 (1990). RN [10] RA Pognonec P., Boulukos K. E., Gesquiere J. C., Stehelin D., Ghysdael J. RT Mitogenic stimulation of thymocytes results in the RT calcium-dependent phosphorylation of c-ets-1 proteins RL EMBO J. 7:977-983 (1988). XX // AC T00116 XX ID T00116 XX DT 26.10.92 (created); ewi. DT 21.05.97 (updated); ewi. XX FA c-Ets-2 58-64 XX SY Ets-2; Ets2; p58-64c-Ets-2; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0016; ETS; 3.5.2.0.2. XX SZ 479 AA; 54.5 kDa (cDNA), 60 kDa, 62 kDa, 64 kDa, 58-64 kDa (SDS) XX SQ MSEFAIRNMDQVAPVSNMYRGMLKRQPAFDTFDSSNSLFAGYFLSLNEDQTLQEVPTGFD SQ STSYESNNCELPLLTPCSKAVMSQALKDTFSGFTKEQCRLGIPNNPWLWTEQHVCQWLAW SQ ATNEFSLANVNIHQFLMSGQDLCNLGKERFLELAPDYVGDILWEHLEQMIKDSQEKTQDQ SQ YVESSHLTSVPHWVNNNSLTVNVDQTPYGIQMPGYPKALSYPKPNLLSDICQTSTGPNLL SQ SPEQDFSLFPKTQVDAVSVNYCTVNQDFTRSNLNLLIDNSGKLREHESSESGAESYESSD SQ SMLQSWNSQSSLVDLQRVPSYESFEDDCSQSLCMSKPTMSFKDYIQDRSDPVEQGKPVIP SQ AAILAGFTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLADPDEVARRWGRRKNKP SQ KMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGYTAEELHAMLGVQPDTED XX SC SwissProt #P10157 XX FT 376 413 tryptophan cluster (W-X17-W-X18-W) XX SF phosphorylation (Ca-dependent) [8]; XX CP predominant expression in T cells XX FF activator [6], [5]; FF functional cooperation with AP-1 [6]; FF rapidly and transiently induced in macrophages in FF response to myelomonocytic growth factor (MGF), LPS or PKC activators [1]; XX BS R02232; PEA3$CONS; Quality: 6 XX DR EMBL: X07202; GGCETS2(r). DR SwissProt: P10157; ETS2_CHICK. DR PIR: S00386; TVCHE2. XX RN [1] RA Boulukos K. E., Pognonec P., Sariban E., Bailly M., Lagrou C., Ghysdael J. RT Rapid and transient expression of Ets2 in mature macrophages RT following stimulation with cMGF, LPS, and PKC activators RL Genes Dev. 4:401-409 (1990). RN [2] RA Ghysdael J., Gegonne A., Pognonec P., Boulukos K. RA E., Leprince D., Lagrou C., Stehelin D. RT Identification in chicken macrophages of a set of RT proteins related to, but distinct from, the chicken RT cellular c-ets-encoded protein p54c-ets RL EMBO J. 5:2251-2256 (1986). RN [3] RA Boulukos K. E., Pognonec P., Begue A., Gailbert F., RA Gesquiere J. C., Stehelin D., Ghysdael J. RT Identification in chickens of an evolutionarily conserved RT cellular ets-2 gene (c-ets-2) encoding nuclear proteins RT related to the product of the c-ets proto-oncogene RL EMBO J. 7:697-705 (1988). RN [4] RA Fujiwara S., Fisher R. J., Seth A., Bhat N. K., Showalter RA S. D., Zweig M., Papas T. S. RT Characterization and localization of the products RT of the human homologs of the v-ets oncogene RL Oncogene 2:99-103 (1988). RN [5] RA Wasylyk C., Gutman A., Nicholson R., Wasylyk B. RT The c-Ets oncoprotein activates the stromelysin promoter RT through the same elements as several non-nuclear oncoproteins RL EMBO J. 10:1127-1134 (1991). RN [6] RA Wasylyk B., Wasylyk C., Flores P., Begue A., Leprince D., Stehelin D. RT The c-ets proto-oncogenes encode transcription factors RT that cooperate with c-Fos and c-Jun for transcriptional activation RL Nature 346:191-193 (1990). RN [7] RA Wasylyk C., Gutman A., Nicholson R., Wasylyk B. RT The c-Ets oncoprotein activates the stromelysin promoter RT through the same elements as several non-nuclear oncoproteins RL EMBO J. 10:1127-1134 (1991). RN [8] RA Pognonec P., Boulukos K. E., Gesquiere J. C., Stehelin D., Ghysdael J. RT Mitogenic stimulation of thymocytes results in the RT calcium-dependent phosphorylation of c-ets-1 proteins RL EMBO J. 7:977-983 (1988). XX // AC T00117 XX ID T00117 XX DT 07.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CF1 XX SY USP; Ultraspiracle; XR2C; chorion factor 1; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX HO RXR XX CL C0002; CC (rec); 2.1.2.12.1. XX SZ 508 AA; 55 kDa (cDNA) XX SQ MDNCDQDASFRLSHIKEEVKPDISQLNDSNNSSFSPKAESPVPFMQAMSMVHVLPGSNSA SQ SSNNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYS SQ CEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQR SQ GARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSI SQ ERIIEAEQRAETQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMP SQ HFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQ SQ PQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDI SQ RGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFR SQ ITSDRPLEELFLEQLEAPPPPGLAMKLE XX SC SwissProt #P20153 XX CP enriched in follicles XX IN T00217; EcR; fruit fly, Drosophila melanogaster. XX MX M00111; I$CF1_01 MX M00112; I$CF1_02 XX BS R03988; AS$ECR_01; Quality: 2 BS R02294; DROME$S15_02; Quality: 2; fruit fly, Drosophila melanogaster BS R01321; HS$RARB_01; Quality: 6; human, Homo sapiens XX DR EMBL: X52591; DMHREC2C(r). DR EMBL: X53417; DMXR2C(r). DR SwissProt: P20153; USP_DROME. DR PIR: A35872; A35872. DR PIR: S11513; S11513. DR PIR: S13119; S13119. DR Flybase: FBgn0003964; usp. XX RN [1] RA Thomas H. E., Stunnenberg H. G., Stewart A. F. RT Heterodimerization of the Drosophila ecdysone receptor RT with retinoid X receptor and ultraspiracle RL Nature 362:471-475 (1993). RN [2] RA Shea M. J., King D. L., Conboy M. J., Mariani B. D., Kafatos F. C. RT Proteins that bind to Drosophila chorion cis-regulatory RT elements: A new C2H2 zinc finger protein and a C2C2 RT steroid receptor-like component RL Genes Dev. 4:1128-1140 (1990). XX // AC T00118 XX ID T00118 XX DT 25.01.93 (created); ewi. DT 22.01.96 (updated); hiwi. XX FA CFF XX SY C1; complex forming factor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 70 kda (sedim.) XX SF 4.4S XX FF assembles Oct-1 through its POU-domain with Vmw65 XX IN T00641; Oct-1; human, Homo sapiens. IN T00894; Vmw65; HSV-1, herpes simplex virus type 1. XX RN [1] RA Kristie T. M., LeBovitz J. H., Sharp P. A. RT The octamer-binding proteins form multi-protein-DNA RT complexes with the HSV alphaTIF regulatory protein RL EMBO J. 8:4229-4238 (1989). RN [2] RA Katan M., Haigh A., Verrijzer C. P., van der Vliet P. C., O'Hare P. RT Characterization of a cellular factor which interacts RT functionally with Oct-1 in the assembly of a multicomponent RT transcription complex RL Nucleic Acids Res. 18:6871- (1990). XX // AC T00119 XX ID T00119 XX DT 10.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CF2-I XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.2.7.1. XX SZ 510 AA XX SQ MIKSTTNPQEQRLPRPEDQSPAPPPPPPSSATTSTAAPATPTHQVATVIANMDTLKTAFL SQ PNLSMDPNVHVSPHYCPMCHQQFERPQHVADHMQLCHGITLNAQGAIATLDGGHPQAQQH SQ PKLSHPCFNCDEKFGNAVDLDEHHRLAHQTPAFLSRCLMCSIYGIHSATQQPNEYKCTQC SQ GSICTTAMLAAGQQGFMEQQEAAVTPDDQLPAMAPRDMRLTPEEQHHQQQLQAEHHHQQQ SQ HQQQQQQQQQQQESLEQQQREMQEQAQQQQVHHHQQDQDLAGDQVALKVPPLTVKLNKNA SQ NGGAIVSHPQVIIKEEPLSLSDSGDVVNSVPVYAIQANPGVPAPASSGVLVGTQTVPADL SQ AHKIRHKCPDCPKTFKTPGTLAMHRKIHTGEADATPKERPYTCSYCGKSFTQSNTLKQHT SQ RIHTGEKPFRCGYCGRAFTVKDYLNKHLTTHTGEKPFHCGYCEKSFSVKDYLTKHIRTHT SQ GEKPYTCPYCDKRFTQRSALTVHTTKLHPL XX SC SwissProt #P20385 XX SF 1+1+5 zinc finger motifs SF splice variants: CF2-II and CF2-III XX CP adult male XX FF late activator in follicle cells during chorion formation XX BS R02317; AS$CF21_01; Quality: 6 BS R02316; DROME$CF2_01; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: M97196; DMBPIS(g). DR EMBL: X53380; DMCF2(r). DR SwissProt: P20385; CF2_DROME. DR PIR: B35872; B35872. DR Flybase: FBgn0000286; Cf2. XX RN [1] RA Hsu T., Gogos J. A., Kirsh S. A., Kafatos F. C. RT Multiple Zinc finger forms resulting from developmentally RT regulated alternative splicing of a transcription factor gene RL Science 257:1946-1950 (1992). XX // AC T00120 XX ID T00120 XX DT 07.11.92 (created); ewi. DT 22.08.96 (updated); ewi. XX FA CF2-II XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.2.7.2. XX SZ 482 AA; 53.5 kDa (cDNA) XX SQ MIKSTTNPQEQRLPRPEDQSPAPPPPPPSSATTSTAAPATPTHQVATVIANMDTLKTAFL SQ PNLSMDPNVHVSPHYCPMCHQQFERPQHVADHMQLCHGITLNAQGAIATLDGGHPQAQQH SQ PKLSHPCFNCDEKFGNAVDLDEHHRLAHQTPAFLSRCLMCSIYGIHSATQQPNEYKCTQC SQ GSICTTAMLAAGQQGFMEQQEAAVTPDDQLPAMAPRDMRLTPEEQHHQQQLQAEHHHQQQ SQ HQQQQQQQQQQQESLEQQQREMQEQAQQQQVHHHQQDQDLAGDQVALKVPPLTVKLNKNA SQ NGGAIVSHPQVIIKEEPLSLSDSGDVVNSVPVYAIQANPGVPAPASSGVLVGTQTVPADL SQ AHKIRHKCPDCPKTFKTPGTLAMHRKIHTGEADATPKERPYTCSYCGKSFTQSNTLKQHT SQ RIHTGEKPFHCGYCEKSFSVKDYLTKHIRTHTGEKPYTCPYCDKRFTQRSALTVHTTKLH SQ PL XX SC SwissProt #P20385 and edited XX SF 1+1+4 zinc finger motifs SF glutamine-rich region SF alternative splicing -> CF2-I and CF2-III XX CP enriched in follicles; embryos XX FF late activator in follicle cells during chorion formation XX MX M00012; I$CF2II_01 MX M00013; I$CF2II_02 XX BS R02318; AS$CF22_01; Quality: 6 BS R02293; DROME$S15_01; Quality: 6; fruit fly, Drosophila melanogaster BS R02295; DROME$S15_03; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: M97196; DMBPIS(g). DR EMBL: X53380; DMCF2(r). DR SwissProt: P20385; CF2_DROME. DR PIR: B35872; B35872. DR Flybase: FBgn0000286; Cf2. XX RN [1] RA Shea M. J., King D. L., Conboy M. J., Mariani B. D., Kafatos F. C. RT Proteins that bind to Drosophila chorion cis-regulatory RT elements: A new C2H2 zinc finger protein and a C2C2 RT steroid receptor-like component RL Genes Dev. 4:1128-1140 (1990). RN [2] RA Hsu T., Gogos J. A., Kirsh S. A., Kafatos F. C. RT Multiple Zinc finger forms resulting from developmentally RT regulated alternative splicing of a transcription factor gene RL Science 257:1946-1950 (1992). RN [3] RA Gogos J. A., Hsu T., Bolton J., Kafatos F. C. RT Sequence discrimination by alternatively spliced isoforms RT of a DNA binding Zinc finger domain RL Science 257:1951-1954 (1992). XX // AC T00121 XX ID T00121 XX DT 10.11.92 (created); empty. DT 23.05.96 (updated); rkn. XX FA CF2-III XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.2.7.3. XX SZ 514 AA XX SQ MIKSTTNPQEQRLPRPEDQSPAPPPPPPSSATTSTAAPATPTHQVATVIANMDTLKTAFL SQ PNLSMDPNVHVSPHYCPMCHQQFERPQHVADHMQLCHGITLNAQGAIATLDGGHPQAQQH SQ PKLSHPCFNCDEKFGNAVDLDEHHRLAHQTPAFLSRCLMCSIYGIHSATQQPNEYKCTQC SQ GSICTTAMLAAGQQGFMEQQEAAVTPDDQLPAMAPRDMRLTPEEQHHQQQLQAEHHHQQQ SQ HQQQQQQQQQQQESLEQQQREMQEQAQQQQVHHHQQDQDLAGDQVALKVPPLTVKLNKNA SQ NGGAIVSHPQVIIKEEPLSLSDSGDVVNSVPVYAIQANPGVPAPASSGVLVGTQTVPADL SQ AHKIRHKCPDCPKTFKTPGTLAMHRKIHTGEAEREAVPLRLLREVLQREGLSDQAHTDAH SQ RREAVHLSVLRQALHAAQRPHCAHDQAASALGKAGRWPPVTRSCPSRSSSSYSSSKSFWS SQ WCAAAVVRRHGYRSQEAICGGCGIGLGRTAAETG XX SC SwissProt #Q01522 XX SF 1+1+1 zinc finger motifs SF splice variants: CF2-I and CF2-II XX CP testis XX FF late activator in follicle cells during chorion formation XX DR EMBL: M97196; DMBPIS(g). DR SwissProt: Q01522; CF23_DROME. DR Flybase: FBgn0000286; Cf2. XX RN [1] RA Hsu T., Gogos J. A., Kirsh S. A., Kafatos F. C. RT Multiple Zinc finger forms resulting from developmentally RT regulated alternative splicing of a transcription factor gene RL Science 257:1946-1950 (1992). XX // AC T00122 XX ID T00122 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA c-Fos XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.1.2.2. XX SZ 380 AA; 40.8 kDa (cDNA), 55-65 kDa (SDS) XX SQ MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANF SQ IPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTQSAGAYARAGMVKTVSGGRA SQ QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ SQ TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEASTPESEEAFT SQ LPLLNDPEPKPSLEPVKSISNVELKAEPFDDFLFPASSRPSGSETSRSVPDVDLSGSFYA SQ ADWEPLHSNSLGMGPMVTELEPLCTPVVTCTPGCTTYTSSFVFTYPEADSFPSCAAAHRK SQ GSSSNEPSSDSLSSPTLLAL XX SC SwissProt #P01101 XX IN T00051; ATF; human, Homo sapiens. IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T00209; E1A 13S protein; adenovirus type 2. IN T00436; JunB; mouse, Mus musculus. IN T00437; Jun-D; mouse, Mus musculus. IN T00902; XBP-1; human, Homo sapiens. IN T00967; E1A 12S protein; adenovirus. IN T01303; CREB-2; human, Homo sapiens. XX BS R03540; AS$AP1_05; Quality: 6 BS R01037; HS$MT2A_08; Quality: 6; human, Homo sapiens BS R01559; HS$VIP_01; Quality: 6; human, Homo sapiens BS R01062; MOUSE$M1H2KB_10; Quality: 6; mouse, Mus musculus XX DR EMBL: V00727; MMCFOS(g). DR EMBL: D12551; MMCFOS01(g). DR EMBL: M23768; MMCFOS5F(g). DR EMBL: J00370; MMFOS(g). DR EMBL: K03231; MMFOSA(g). DR EMBL: M65003; MMFOSERE(g). DR SwissProt: P01101; FOS_MOUSE. DR PIR: A01343; TVMSF. DR Compel: C00075 DR Compel: C00081 DR Compel: C00133 DR Compel: C00134 XX RN [1] RA Schuermann M., Neuberg M., Hunter J. B., Jenuwein RA T., Ryseck R.-P., Bravo R., Mueller R. RT The leucine repeat motif in Fos protein mediates complex RT formation with Jun/AP-1 and is required for transformation RL Cell 56:507-516 (1989). RN [2] RA Schuermann M., Hunter J. B., Henning G., Mueller R. RT Non-leucine residues in the leucine repeats of Fos RT and Jun contribute to the stability and determine RT the specificity of dimerization RL Nucleic Acids Res. 19:739-746 (1991). RN [3] RA Sassone-Corsi P., Lamph W. W., Kamps M., Verma I. M. RT fos-associated cellular p39 is related to nuclear transcription factor AP-1 RL Cell 54:553-560 (1988). RN [4] RA Distel R. J., Ro H.-S., Rosen B. S., Groves D. L., Spiegelman B. M. RT Nucleoprotein complexes that regulate gene expression RT in adipocyte differentiation: direct participation of c-fos RL Cell 49:835-844 (1987). RN [5] RA Kataoka K., Noda M., Nishizawa M. RT Maf nuclear oncoprotein recognizes sequences related RT to an AP-1 site and forms heterodimers with both Fos and Jun RL Mol. Cell. Biol. 14:700-712 (1994). RN [6] RA Kouzarides T., Ziff E. RT The role of the leucine zipper in the fos-jun interaction RL Nature 336:646-651 (1988). RN [7] RA Curran T., Miller A. D., Zokas L., Verma I. M. RT Viral and cellular fos proteins: a comparative analysis RL Cell 36:259-268 (1984). RN [8] RA Neuberg M., Adamkiewicz J., Hunter J. B., Mueller R. RT A Fos protein containing the leucine zipper forms RT a homodimer which binds to the AP1 binding site RL Nature 341:243-245 (1989). RN [9] RA Curran T., Teich N. M. RT Candidate product of the FBJ murine osteosarcoma virus RT oncogene: characterization of a 55,000-Dalton phosphoprotein RL J. Virol. 42:114-122 (1982). RN [10] RA Curran T., Peters G., van Beveren C., Teich N. M., Verma I. M. RT FBJ murine osteosarcoma virus: identification and RT molecular cloning of biologically active proviral DNA RL J. Virol. 44:674-682 (1982). RN [11] RA Curran T., Verma I. M. RT FBR murine osteosarcoma virus RL Virology 135:218-228 (1984). RN [12] RA Lucibello F. C., Lowag C., Neuberg M., Mueller R. RT Trans-repression of the mouse c-fos promoter: A novel RT mechanism of fos-mediated trans-regulation RL Cell 59:999-1007 (1989). RN [13] RA Sambucetti L. C., Curran T. RT The Fos protein complex is associated with DNA in RT isolated nuclei and binds to DNA cellulose RL Science 234:1417-1419 (1986). RN [14] RA Kruijer W., Cooper J. A., Hunter T., Verma I. M. RT Platelet-derived growth factor induces rapid but transient RT expression of the c-fos gene and protein RL Nature 312:711-716 (1984). RN [15] RA Mueller R., Bravo R., Burckhardt J., Curran T. RT Induction of c-fos gene and protein by growth factors RT precedes activation of c-myc RL Nature 312:716-720 (1984). RN [16] RA Curran T., Morgan J. I. RT Superinduction of c-fos by nerve growth factor in RT the presence of peripherally active benzodiazepines RL Science 229:1265-1268 (1985). RN [17] RA Neuberg M., Schuermann M., Hunter J. B., Mueller R. RT Two functionally different regions in Fos are required RT for the equence-specific DNA-interaction of the Fos/Jun protein complex RL Nature 338:589-590 (1989). RN [18] RA Abate C., Luk D., Curran T. RT Transcriptional regulation by Fos and Jun in vitro: RT Interaction among multiple activator and regulator domains RL Mol. Cell. Biol. 11:3624-3632 (1991). RN [19] RA Wisdom R., Verma I. M. RT Transformation by Fos proteins requires a C-terminal transactivation domain RL Mol. Cell. Biol. 13:7429-7438 (1993). RN [20] RA Jooss K. U., Funk M., Mueller R. RT An autonomous N-terminal transactivation domain in RT Fos protein plays a crucial role in transformation RL EMBO J. 13:1467-1475 (1994). RN [21] RA Kerppola T. K., Curran T. RT Selective DNA bending by a variety of bZIP proteins RL Mol. Cell. Biol. 13:5479-5489 (1993). RN [22] RA Bannister A. J., Brown H. J., Sutherland J. A., Kouzarides T. RT Phosphorylation of the c-Fos and c-Jun HOB1 motif RT stimulates its activation capacity RL Nucleic Acids Res. 22:5173-5176 (1994). RN [23] RA Deng T., Karin M. RT c-Fos transcriptional activity stimulated by H-Ras-activated RT protein kinase distinct from JNK and ERK RL Nature 371:171-175 (1994). RN [24] RA Ofir R., Dwarki V. J., Rashid D., Verma I. M. RT Phosphorylation of the C terminus of Fos protein is RT required for transcriptional transrepression of the c-fos promoter RL Nature 348:80-82 (1990). RN [25] RA Colotta et al. RT - RL J. Biol. Chem. 267:18278-18283 (1992). RN [26] RA Smeyne et al. RT - RL Nature 363:166- (1993). RN [27] RA Lord et al. RT - RL Mol. Cell. Biol. 13:841-851 (1993). RN [28] RA Roux P., Blanchard J.-M., Fernandez A., Lamb N., Jeanteur P., Piechaczyk M. RT Nuclear localization of c-Fos, but not v-Fos proteins, RT is controlled by extracellular signals RL Cell 63:341-351 (1990). RN [29] RA Schoenthal A., Herrlich P., Rahmsdorf H. J., Ponta H. RT Requirement for fos gene expression in the transcriptional RT activation of collagenase by other oncogenes and phorbol esters RL Cell 54:325-334 (1988). RN [30] RA Chiu R., Boyle W. J., Meek J., Smeal T., Hunter T., Karin M. RT The c-fos protein interacts with c-jun/AP-1 to stimulate RT transcription of AP-1 responsive genes RL Cell 54:541-552 (1988). RN [31] RA Xanthoudakis S., Curran T. RT Identification and characterization of Ref-1, a nuclear RT protein that facilitates AP-1 DNA-binding activity RL EMBO J. 11:653-665 (1992). RN [32] RA Johnson R. S., Spiegelman B. M., Papaioannou V. RT Pleiotropic effects of a null mutation in the c-fos proto-oncogene RL Cell 71:577-586 (1992). RN [33] RA Rauscher III F. J., Sambucetti L. C., Curran T., Distel RA R. J., Spiegelman B. M. RT Common DNA binding site for Fos protein complexes RT and transcription factor AP-1 RL Cell 52:471-480 (1988). RN [34] RA Abate C., Baker S. J., Lees-Miller S. P., Anderson RA C. W., Marshak D. R., Curran T. RT Dimerization and DNA binding alter phosphorylation of Fos and Jun RL Proc. Natl. Acad. Sci. USA 90:6766-6770 (1993). RN [35] RA Koenig H., Ponta H., Rahmsdorf U., Buescher M., Schoenthal RA A., Rahmsdorf H. J., Herrlich P. RT Autoregulation of fos: the dyad symmetry element as RT the major target of repression RL EMBO J. 8:2559-2566 (1989). RN [36] RA Berkowitz L. A., Riabowol K. T., Gilman M. Z. RT Multiple sequence elements of a single functional RT class are required for cyclic AMP responsiveness of the mouse c-fos promoter RL Mol. Cell. Biol. 9:4272-4281 (1989). RN [37] RA Fujii M., Shalloway D., Verma I. M. RT Gene regulation by tyrosine kinases: src protein activates RT various promoters, including c-fos RL Mol. Cell. Biol. 9:2493-2499 (1989). RN [38] RA Haertig E., Loncarevic I. F., Buescher M., Herrlich P., Rahmsdorf H. J. RT A new cAMP response element in the transcribed region RT of the human c-fos gene RL Nucleic Acids Res. 19:4153-4159 (1990). RN [39] RA Foulkes N. S., Laoide B. M., Schlotter F., Sassone-Corsi P. RT Transcriptional antagonist cAMP-responsive element RT modulator (CREM) down-regulates c-fos cAMP-induced expression RL Proc. Natl. Acad. Sci. USA 88:5448-5452 (1991). RN [40] RA Gutman A., Wasylyk C., Wasylyk B. RT Cell-specific regulation of oncogene-responsive sequences RT of the c-fos promoter RL Mol. Cell. Biol. 11:5381-5387 (1991). RN [41] RA Lucibello F. C., Ehlert F., Mueller R. RT Multiple interdependent regulatory sites in the mouse RT c-fos promoter determine basal level transcription: RT cell type-specific effects RL Nucleic Acids Res. 19:3583-3591 (1991). RN [42] RA Rao G. N., LassJgue B., Griendling K. K., Alexander R. W., Berk B. C. RT Hydrogen peroxide-induced c-fos expression is mediated RT by arachidonic acid release: role of protein kinase C RL Nucleic Acids Res. 21:1259-1263 (1993). RN [43] RA Shibuya H., Kohu K., Yamada K., Barsoumian E. L., RA Perlmutter R. M., Taniguchi T. RT Functional dissection of p56lck, a protein tyrosine RT kinase which mediates interleukin-2-induced activation of the c-fos gene RL Mol. Cell. Biol. 14:5812-5819 (1994). RN [44] RA Mechti N., Piechaczyk M., Blanchard J.-M., Jeanteur P., Lebleu B. RT Sequence requirements for premature transcription RT arrest within the first intron of the mouse c-fos gene RL Mol. Cell. Biol. 11:2832-2841 (1991). RN [45] RA Collart M. A., Tourkine N., Belin D., Vassalli P., RA Jeanteur P., Blanchard J.-M. RT c-fos gene transcription in murine macrophages is RT modulated by a calcium-dependent block to elongation in intron 1 RL Mol. Cell. Biol. 11:2826-231 (1991). RN [46] RA Roy N., Laflamme G., Raymond V. RT 5' untranslated sequences modulate rapid mRNA degradation RT mediated by 3' AU-rich element in v-/c-fos recombinants RL Nucleic Acids Res. 20:5753-5762 (1992). RN [47] RA Wellington C. L., Greenberg M. E., Belasco J. G. RT The destabilizing elements in the coding region of RT c-fos mRNA are recognized as RNA RL Mol. Cell. Biol. 13:5034-5042 (1993). RN [48] RA Kovary K., Bravo R. RT Existence of different Fos/Jun complexes during the RT G0-to-G1 transition and during exponential growth RT in mouse fibroblasts: differential role of Fos proteins RL Mol. Cell. Biol. 12:5015-5023 (1992). RN [49] RA Trouche D., Grigoriev M., Lenormand J.-L., Robin P., RA Leibovitch S. A., Sassone-Corsi P., Harel-Bellan A. RT Repression of c-fos promoter by MyoD on muscle cell differentiation RL Nature 363:79-82 (1993). RN [50] RA Sadowski H. B., Gilman M. Z. RT Cell-free activation of a DNA-binding protein by epidermal growth factor RL Nature 362:79-83 (1993). RN [51] RA Kim J., Struhl K. RT Determinants of half-site spacing preferences that RT distinguish AP-1 and ATF/CREB bZIP domains RL Nucleic Acids Res. 23:2531-2537 (1995). RN [52] RA Hsu W., Kerppola T. K., Chen P. L., Curran T., Chen-Kiang S. RT Fos and Jun repress transcription activation by NF-IL6 RT through association at the basic zipper region RL Mol. Cell. Biol. 14:268-276 (1994). RN [53] RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M. RT Fos-Jun interaction: mutational analysis of the leucine RT zipper domain of both proteins RL Genes Dev. 3:770-781 (1989). RN [54] RA Takimoto M., Quinn J. P., Farina A. R., Staudt L. M., Levens D. RT fos/jun and Octamer-binding Protein Interact with RT a Common Site in a Negative Element of the Human c-myc Gene RL J. Biol. Chem. 264:8982-8999 (1989). RN [55] RA Nakabeppu Y., Nathans D. RT The basic region of Fos mediates specific DNA binding RL EMBO J. 8:3833-3841 (1989). RN [56] RA Fink J. S., Verhave M., Walton K., Mandel G., Goodman R. H. RT Cyclic AMP- and phorbol ester-induced transcriptional RT activation are mediated by the same enhancer element RT in the human vasoactive intestinal peptide gene RL J. Biol. Chem. 266:3882-3887 (1991). RN [57] RA de Groot R. P., Karperien M., Pals C., Kruijer W. RT Characterization of the mouse junD promoter - high RT basal level activity due to an octamer motif RL EMBO J. 10:2523-2532 (1991). RN [58] RA Saffen D. W., Cole A. J., Worley P. F., Christy B. RA A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor RT messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [59] RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate RT distinct programs of early response gene expression: RT dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [60] RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription RT factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [61] RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate RT in transcriptional activation in an interdependent manner RL New Biologist 1:35-43 (1989). RN [62] RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation RT is due to increased c-Jun transcription RL New Biologist 2:351-361 (1990). RN [63] RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., RA Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation RT of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [64] RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity RT is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [65] RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [66] RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus RT enhancer are independently the targets of stimulation RT by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate RT and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [67] RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor RT involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [68] RA Gius D., Cao X., Rauscher III. F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are RT Independent Functions: The C Terminus Represses Immediate-Early RT Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). XX // AC T00123 XX ID T00123 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA c-Fos XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0008; bZIP; 1.1.1.2.2. XX SZ 380 AA; 40.7 kDa (cDNA), 55-65 kDa (SDS) XX SQ MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF SQ IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA SQ QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ SQ TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT SQ LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA SQ ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK SQ GSSSNEPSSDSLSSPTLLAL XX SC SwissProt #P01100 XX FF activator (heterodimer with c-jun); FF repressor of its own expression; FF involved in negative regulation of myc; FF enhanced mRNA levels after thrombin treatment after 0.5h [8]; XX IN T00051; ATF; human, Homo sapiens. IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T00167; CRE-BP1; human, Homo sapiens. IN T00209; E1A 13S protein; adenovirus type 2. IN T00337; GR alpha; human, Homo sapiens. IN T00436; JunB; mouse, Mus musculus. IN T00437; Jun-D; mouse, Mus musculus. IN T00581; C/EBPbeta; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T00878; USF2; human, Homo sapiens. IN T00902; XBP-1; human, Homo sapiens. IN T00967; E1A 12S protein; adenovirus. IN T01082; AS321; human, Homo sapiens. IN T01303; CREB-2; human, Homo sapiens. IN T01920; GR beta; human, Homo sapiens. IN T02115; USF2; rat, Rattus norvegicus. XX BS R02666; AS$AP1_01; Quality: 6 BS R03910; AS$AP1_07; Quality: 2 BS R02667; AS$CRE_01; Quality: 6 BS R01195; CHICK$OA_04; Quality: 1; chick, Gallus gallus BS R00199; EBV$BZLF1_03; Quality: 6; EBV, Epstein-Barr virus BS R02453; HS$BG_11; Quality: 6; human, Homo sapiens BS R00235; HS$CLASE_01; Quality: 6; human, Homo sapiens BS R04127; HS$ET1_02; Quality: 3; human, Homo sapiens BS R03522; HS$IL2_12; Quality: 6; human, Homo sapiens BS R03105; HS$M2DPB_01; Quality: 6; human, Homo sapiens BS R03104; HS$M2DRA_10; Quality: 6; human, Homo sapiens BS R01037; HS$MT2A_08; Quality: 6; human, Homo sapiens BS R01258; HS$PK_03; Quality: 6; human, Homo sapiens BS R02454; MMTV$MMTV_36; Quality: 6; MMTV, mouse mammary tumor virus BS R04032; MOUSE$CJUN_03; Quality: 1; mouse, Mus musculus BS R03386; MOUSE$JUND_06; Quality: 6; mouse, Mus musculus BS R01285; MOUSE$PLF_01; Quality: 6; mouse, Mus musculus XX DR EMBL: V01512; HSCFOS(g). DR EMBL: M15429; HSCFOS01(g). DR EMBL: X53723; HSCFOSRE(g). DR EMBL: K00650; HSFOS(g). DR SwissProt: P01100; FOS_HUMAN. DR PIR: A01342; TVHUF1. DR Compel: C00079 DR Compel: C00082 DR Compel: C00083 DR Compel: C00138 DR PDB: 1fos; TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES. XX RN [1] RA Turner R., Tjian R. RT Leucine repeats and an adjacent DNA binding domain RT mediate the formation of functional cFos-cJun heterodimers RL Science 243:1689-1694 (1989). RN [2] RA Gentz R., Rauscher III F. J., Abate C., Curan T. RT Parallel association of Fos and Jun leucine zippers RT juxtaposes DNA binding domains RL Science 243:1695-1699 (1989). RN [3] RA Sassone-Corsi P., Lamph W. W., Kamps M., Verma I. M. RT fos-associated cellular p39 is related to nuclear transcription factor AP-1 RL Cell 54:553-560 (1988). RN [4] RA van Straaten F., Mueller R., Curran T., van Beveren C., Verma I. M. RT Complete nucleotide sequence of a human c-onc gene: RT Deduced amino acid sequence of the human c-fos proten RL Proc. Natl. Acad. Sci. USA 80:3183-3187 (1983). RN [5] RA Hai T., Curran T. RT Cross-family dimerization of transcription factors RT Fos/Jun and ATF/CREB alters DNA binding specificity RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991). RN [6] RA Bohmann D., Bos T. J., Admon A., Nishimura T., Vogt P. K., Tjian R. RT Human proto-oncogene c-jun encodes a DNA binding protein RT with structural and functional properties of transcription factor AP-1 RL Science 238:1386-1392 (1987). RN [7] RA Franza Jr. B. R., Rauscher III F. J., Josephs S. F., Curran T. RT The Fos-complex and Fos-related antigens recognize RT sequence elements that contain AP-2 binding sites RL Science 239:1150-1153 (1988). RN [8] RA Trejo J., Chambard J.-C., Karin M., Brown J. H. RT Biphasic increase in c-jun mRNA is required for induction RT of AP-1-mediated gene transcription: Differential RT effects of muscarinic and thrombin receptor activation RL Mol. Cell. Biol. 12:4742- 4750 (1992). RN [9] RA Rauscher III F. J., Cohen D. R., Curran T., Bos T. RA J., Vogt P. K., Bohmann D., Tjian R., B. R. Franza jr. RT Fos-associated protein p39 is the product of the jun proto-oncogene RL Science 240:1010-1016 (1988). RN [10] RA Metz R., Bannister A. J., Sutherland J. A., Hagemeier RA C., O'Rourke E. C., Cook A., Bravo R., Kouzarides T. RT c-Fos-induced activation of a TATA-box-containing RT promoter involves direct contact with TATA-box-binding protein RL Mol. Cell. Biol. 14:6021-6029 (1994). RN [11] RA Natoli G., Laura M., Avantaggiati , Chirillo P., Costanzo RA A., Artini M., Balsano C., Levrero M. RT Induction of the DNA-binding activity of c-Jun/c-Fos RT heterodimers by the hepatitis B virus transactivator RL Mol. Cell. Biol. 14:989-998 (1994). RN [12] RA Xanthoudakis S., Curran T. RT Redox activation of Fos-Jun DNA binding activity is RT mediated by a DNA repair enzyme RL EMBO J. 11:3323-3335 (1992). RN [13] RA Rauscher III F. J., Sambucetti L. C., Curran T., Distel RA R. J., Spiegelman B. M. RT Common DNA binding site for Fos protein complexes RT and transcription factor AP-1 RL Cell 52:471-480 (1988). RN [14] RA Koenig H., Ponta H., Rahmsdorf U., Buescher M., Schoenthal RA A., Rahmsdorf H. J., Herrlich P. RT Autoregulation of fos: the dyad symmetry element as RT the major target of repression RL EMBO J. 8:2559-2566 (1989). RN [15] RA Fisch T. M., Prywes R., Roeder R. G. RT An AP1-binding site in the c-fos gene can mediate RT induction by epidermal growth factor and 12-O-tetradecanoyl RT phorbol-13-acetate RL Mol. Cell. Biol. 9:1327-1331 (1989). RN [16] RA Fujii M., Shalloway D., Verma I. M. RT Gene regulation by tyrosine kinases: src protein activates RT various promoters, including c-fos RL Mol. Cell. Biol. 9:2493-2499 (1989). RN [17] RA Weisz A., Rosales R. RT Identification of an estrogen response element upstream RT of the human c-fos gene that binds the estrogen receptor RT and the AP-1 transcription factor RL Nucleic Acids Res. 18:5097-5106 (1990). RN [18] RA Robbins P. D., Horowitz J. M., Mulligan R. C. RT Negative regulation of human c-fos expression by the RT retinoblastoma gene product RL Nature 346:668-671 (1990). RN [19] RA Kley N., Chung R. Y., Say S., Loeffler J. P., Seizinger B. R. RT Repression of the basal c-fos promoter by wild-type p53 RL Nucleic Acids Res. 20:4083-4087 (1992). RN [20] RA Gutman A., Wasylyk C., Wasylyk B. RT Cell-specific regulation of oncogene-responsive sequences RT of the c-fos promoter RL Mol. Cell. Biol. 11:5381-5387 (1991). RN [21] RA Velcich A., Ziff E. B. RT Functional analysis of an isolated fos promoter element RT with AP-1 site homology reveals cell type-specific RT transcriptional properties RL Mol. Cell. Biol. 10:6273-6282 (1990). RN [22] RA Meyer D. J., Stephenson E. W., Johnson L., Cochran B. H., Schwartz J. RT The serum response element can mediate induction of c-fos by growth hormone RL Proc. Natl. Acad. Sci. USA 90:6721-6725 (1993). RN [23] RA Meyer M., Schreck R., Baeuerle P. A. RT H2O2 and antioxidants have opposite effects on activation RT of NF-6B and AP-1 in intact cells: AP-1 as secondary RT antioxidant-responsive factor RL EMBO J. 12:2005-2015 (1993). RN [24] RA Fu X.-Y., Zhang J.-J. RT Transcription factor p91 interacts with the epidermal RT growth factor receptor and mediates activation of the c-fos gene promoter RL Cell 74:1135-1145 (1993). RN [25] RA Kabnick K. S., Housman D. E. RT Determinants that contribute to cytoplasmic stability RT of human c-fos and $-globin mRNAs are located at several sites in each mRNA RL Mol. Cell. Biol. 8:3244-3250 (1988). RN [26] RA Shyu A.-B., Greenberg M. E., Belasco J. G. RT The c-fos transcript is targeted for rapid decay by RT two distinct mRNA degradation pathways RL Genes Dev. 3:60-72 (1989). RN [27] RA Hayes T. E., Kitchen A. M., Cochran B. H. RT Inducible binding of a factor to the c-fos regulatory region RL Proc. Natl. Acad. Sci. USA 84:1272-1276 (1987). RN [28] RA Wagner B. J., Hayes T. E., Hoban C. J., Cochran B. H. RT The SIF binding element confers sis/PDGF inducibility RT onto the c-fos promoter RL EMBO J. 9:4477-4484 (1990). RN [29] RA Sadowski H. B., Gilman M. Z. RT Cell-free activation of a DNA-binding protein by epidermal growth factor RL Nature 362:79-83 (1993). RN [30] RA Glover J. N. M., Harrison S. C. RT Crystal structure of the heterodimeric bZIP transcription RT factor c-Fos-c-Jun bound to DNA RL Nature 373:257-261 (1995). RN [31] RA Treisman R. RT - RL Cell 42:889-902 (1985). RN [32] RA Treisman R. RT Identification of a protein-binding site that mediates RT transcriptional response of the c-fos gene to serum factors RL Cell 46:567-574 (1986). RN [33] RA Yaseen N. R., Park J., Kerppola T., Curran T., Sharma S. RT A central role for Fos in human B- and T-cell NFAT RT (nuclear factor of activated T cells): an acidic region RT is required for in vitro assembly RL Mol. Cell. Biol. 14:6886-6895 (1994). RN [34] RA Stein B., A. S. Baldwin jr., Ballard D. W., Greene RA W. C., Angel P., Herrlich P. RT Cross-coupling of the NF-6B p65 and Fos/Jun transcription RT factors produces potentiated biological function RL EMBO J. 12:3879-3891 (1993). RN [35] RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M. RT Fos-Jun interaction: mutational analysis of the leucine RT zipper domain of both proteins RL Genes Dev. 3:770-781 (1989). RN [36] RA Sassone-Corsi P., Visvader J., Ferland L., Mellon P. L., Verma I. M. RT Induction of proto-oncogene fos transcription through RT the adenylate cyclase pathway: characterization of a cAMP-responsive element RL Genes Dev. 2:1529-1538 (1988). RN [37] RA Lee W. M. F., Lin C., Curran T. RT Activation of the transforming potential of the human RT fos proto-oncogene requires message stabilizatiob RT and results in increased amounts of partially modified fos protein RL Mol. Cell. Biol. 8:5521-5527 (1988). RN [38] RA Fisch T. M., Prywes R., Roeder R. G. RT c-fos Sequences Necessary for Basal Expression and RT Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl RT Phorbol-13-Acetate, and the Calcium Ionophore RL Mol. Cell. Biol. 7:3490-3502 (1987). RN [39] RA Takimoto M., Quinn J. P., Farina A. R., Staudt L. M., Levens D. RT fos/jun and Octamer-binding Protein Interact with RT a Common Site in a Negative Element of the Human c-myc Gene RL J. Biol. Chem. 264:8982-8999 (1989). RN [40] RA Hay N., Takimoto M., Bishop J. M. RT A FOS protein is present in a complex that binds a negative regulator of MYC RL Genes Dev. 3:293-303 (1989). RN [41] RA Nakabeppu Y., Nathans D. RT The basic region of Fos mediates specific DNA binding RL EMBO J. 8:3833-3841 (1989). RN [42] RA Ono S. J., Bazil V., Levi B.-Z., Ozato K., Strominger J. L. RT Transcription of a subset of human class II major RT histocompatibility complex genes is regulated by a RT nucleoprotein complex that contains c-fos or an antigenically RT related protein RL Proc. Natl. Acad. Sci. USA 88:4304-4308 (1991). RN [43] RA Fink J. S., Verhave M., Walton K., Mandel G., Goodman R. H. RT Cyclic AMP- and phorbol ester-induced transcriptional RT activation are mediated by the same enhancer element RT in the human vasoactive intestinal peptide gene RL J. Biol. Chem. 266:3882-3887 (1991). RN [44] RA Buttice G., Quinones S., Kurkinen M. RT The AP-1 site is required for basal expression but RT is not necessary for TPA-response of the human stromelysin gene RL Nucleic Acids Res. 19:3723-3731 (1991). RN [45] RA de Groot R. P., Karperien M., Pals C., Kruijer W. RT Characterization of the mouse junD promoter - high RT basal level activity due to an octamer motif RL EMBO J. 10:2523-2532 (1991). RN [46] RA Halazonetis T. D., Georgopoulos K., Greenberg M. E., Leder P. RT c-jun dimerizes with itself and with c-Fos, forming RT complexes of different DNA binding affinities RL Cell 55:917-924 (1988). RN [47] RA Saffen D. W., Cole A. J., Worley P. F., Christy B. RA A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor RT messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [48] RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate RT distinct programs of early response gene expression: RT dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [49] RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription RT factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [50] RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate RT in transcriptional activation in an interdependent manner RL New Biologist 1:35-43 (1989). RN [51] RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation RT is due to increased c-Jun transcription RL New Biologist 2:351-361 (1990). RN [52] RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., RA Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation RT of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [53] RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity RT is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [54] RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [55] RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus RT enhancer are independently the targets of stimulation RT by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate RT and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [56] RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor RT involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [57] RA Gius D., Cao X., Rauscher III. F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are RT Independent Functions: The C Terminus Represses Immediate-Early RT Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). XX // AC T00124 XX ID T00124 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA c-Fos XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.1.2.2. XX SZ 380 AA; 40.9 kDa (cDNA), 55-65 kDa (SDS) XX SQ MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANF SQ IPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTPSTGAYARAGVVKTMSGGRA SQ QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ SQ TEIANLLKEKEKLEFILAAHRPACKIPNDLGFPEEMSVTSLDLTGGLPEATTPESEEAFT SQ LPLLNDPEPKPSLEPVKNISNMELKAEPFDDFLFPASSRPSGSETARSVPDVDLSGSFYA SQ ADWEPLHSSSLGMGPMVTELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRK SQ GSSSNEPSSDSLSSPTLLAL XX SC SwissProt #P12841 XX FF transcriptional activator and repressor; FF represses transcription of its own gene and of ANF FF through the C-terminal domain distinct from the activation FF domain and through a distinct DNA element [9]; XX IN T00051; ATF; human, Homo sapiens. IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T00209; E1A 13S protein; adenovirus type 2. IN T00436; JunB; mouse, Mus musculus. IN T00437; Jun-D; mouse, Mus musculus. IN T00902; XBP-1; human, Homo sapiens. IN T00967; E1A 12S protein; adenovirus. IN T01303; CREB-2; human, Homo sapiens. XX BS R03668; AS$AP1_06; Quality: 6 BS R04330; HS$ANF_03; Quality: 2; human, Homo sapiens BS R00592; HS$GHA_02; Quality: 6; human, Homo sapiens BS R03059; HS$STROM_02; Quality: 6; human, Homo sapiens BS R01358; RAT$SSTA_01; Quality: 6; rat, Rattus norvegicus BS R01491; RAT$TH_01; Quality: 6; rat, Rattus norvegicus BS R01460; RAT$TS_01; Quality: 6; rat, Rattus norvegicus BS R01383; SV$SV40_15; Quality: 6; SV40, simian virus 40 XX DR EMBL: U02631; RN02631(g). DR EMBL: X06769; RNCFOSR(r). DR SwissProt: P12841; FOS_RAT. DR PIR: A28263; TVRTFS. DR Compel: C00141 DR Compel: C00142 DR Compel: C00143 XX RN [1] RA Patel L., Abate C., Curan T. RT Altered protein conformation on DNA binding by Fos and Jun RL Nature 347:572-574 (1990). RN [2] RA Turner R., Tjian R. RT Leucine repeats and an adjacent DNA binding domain RT mediate the formation of functional cFos-cJun heterodimers RL Science 243:1689-1694 (1989). RN [3] RA Gentz R., Rauscher III F. J., Abate C., Curan T. RT Parallel association of Fos and Jun leucine zippers RT juxtaposes DNA binding domains RL Science 243:1695-1699 (1989). RN [4] RA Abate C., Luk D., Gentz R., Rauscher III F. J., Curran T. RT Expression and purification of the leucine zipper RT and DNA-binding domains of Fos and Jun: Both Fos and RT Jun contact DNA directly RL Proc. Natl. Acad. Sci. USA 87:1032-1036 (1990). RN [5] RA Hai T., Curran T. RT Cross-family dimerization of transcription factors RT Fos/Jun and ATF/CREB alters DNA binding specificity RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991). RN [6] RA Maguire K., Shi X.-P., Horikoshi N., Rappaport J., Rosenberg M., Weinmann R. RT Interactions between adenovirus E1A and members of RT the AP-1 family of cellular transcription factors RL Oncogene 6:1417-1422 (1991). RN [7] RA Kouzarides T., Ziff E. RT The role of the leucine zipper in the fos-jun interaction RL Nature 336:646-651 (1988). RN [8] RA Kouzarides T., Ziff E. RT Leucine zippers of fos, jun and GCN4 dictate dimerization RT specificity and thereby control DNA binding RL Nature 340:568-571 (1989). RN [9] RA Kovacic-Milivojevic B., Gardner D. G. RT Divergent regulation of the human atrial natriuretic RT peptide gene by c-jun and c-fos RL Mol. Cell. Biol. 12:292-301 (1992). RN [10] RA Naranjo J. R., Mellstroem B., Auwerx J., Mollinedo F., Sassone-Corsi P. RT Unusual c-fos induction upon chromaffin PC12 differentiation RT by sodium butyrate: loss of fos autoregulatory function RL Nucleic Acids Res. 18:3605-3610 (1990). RN [11] RA Curran T., Morgan J. I. RT Superinduction of c-fos by nerve growth factor in RT the presence of peripherally active benzodiazepines RL Science 229:1265-1268 (1985). RN [12] RA Abate C., Patel L., Rauscher III F. J., Curran T. RT Redox regulation of Fos and Jun DNA-binding activity in vitro RL Science 249:1157-1161 (1990). RN [13] RA Kerppola T. K., Curran T. RT DNA bending by Fos and Jun: the flexible hinge model RL Science 254:1210-1214 (1991). RN [14] RA Kerppola T. K., Curran T. RT Fos-Jun heterodimers and Jun homodimers bend DNA in RT opposite orientations: implications for transcription factor cooperativity RL Cell 66:317-326 (1991). RN [15] RA Sutherland J. A., Cook A., Bannister A. J., Kouzarides T. RT Conserved motifs in Fos and Jun define a new class of activation domain RL Genes Dev. 6:1810-1819 (1992). RN [16] RA Brown H. J., Sutherland J. A., Cook A., Bannister A. J., Kouzarides T. RT An inhibitor domain in c-Fos regulates activation RT domains containing the HOB1 motif RL EMBO J. 14:124-131 (1995). RN [17] RA Rauscher III F. J., Sambucetti L. C., Curran T., Distel RA R. J., Spiegelman B. M. RT Common DNA binding site for Fos protein complexes RT and transcription factor AP-1 RL Cell 52:471-480 (1988). RN [18] RA Fukumoto Y., Kaibuchi K., Oku N., Hori Y., Takai Y. RT Activation of the serum-response element by the activated RT c-Ha-ras protein in a manner independent of protein RT kinase C and cAMP-dependent protein kinase RL J. Biol. Chem. 265:774-780 (1990). RN [19] RA Gauthier-Rouviere C., Fernandez A., Lamb N. J. C. RT ras-induced c-fos expression and proliferation in RT living rat fibroblasts involves C-kinase activation RT and the serum response element pathway RL EMBO J. 9:171-180 (1990). RN [20] RA Sassone-Corsi P., Visvader J., Ferland L., Mellon P. L., Verma I. M. RT Induction of proto-oncogene fos transcription through RT the adenylate cyclase pathway: characterization of a cAMP-responsive element RL Genes Dev. 2:1529-1538 (1988). RN [21] RA Rauscher III. F. J., Voulalas P. J., Franza Jr. B. R., Curran T. RT Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro RL Genes Dev. 2:1687-1699 (1988). RN [22] RA Hay N., Takimoto M., Bishop J. M. RT A FOS protein is present in a complex that binds a negative regulator of MYC RL Genes Dev. 3:293-303 (1989). RN [23] RA Ono S. J., Bazil V., Levi B.-Z., Ozato K., Strominger J. L. RT Transcription of a subset of human class II major RT histocompatibility complex genes is regulated by a RT nucleoprotein complex that contains c-fos or an antigenically RT related protein RL Proc. Natl. Acad. Sci. USA 88:4304-4308 (1991). RN [24] RA Buttice G., Quinones S., Kurkinen M. RT The AP-1 site is required for basal expression but RT is not necessary for TPA-response of the human stromelysin gene RL Nucleic Acids Res. 19:3723-3731 (1991). RN [25] RA Saffen D. W., Cole A. J., Worley P. F., Christy B. RA A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor RT messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [26] RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate RT distinct programs of early response gene expression: RT dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [27] RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription RT factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [28] RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate RT in transcriptional activation in an interdependent manner RL New Biologist 1:35-43 (1989). RN [29] RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation RT is due to increased c-Jun transcription RL New Biologist 2:351-361 (1990). RN [30] RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., RA Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation RT of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [31] RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity RT is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [32] RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [33] RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus RT enhancer are independently the targets of stimulation RT by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate RT and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [34] RA Gius D., Cao X., Rauscher III. F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are RT Independent Functions: The C Terminus Represses Immediate-Early RT Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). XX // AC T00125 XX ID T00125 XX DT 25.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA c-Fos XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0008; bZIP; 1.1.1.2.2. XX SZ 367 AA; 39 kDa (cDNA), 55-65 kDa (SDS) XX SQ MMYQGFAGEYEAPSSRCSSASPAGDSLTYYPSPADSFSSMGSPVNSQDFCTDLAVSSANF SQ VPTVTAISTSPDLQWLVQPTLISSVAPSQNRGHPYGVPAPAPPAAYSRPAVLKAPGGRGQ SQ SIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEEEKSALQA SQ EIANLLKEKEKLEFILAAHRPACKMPEELRFSEELAAATALDLGAPSPAAAEEAFALPLM SQ TEAPPAVPPKEPSGSGLELKAEPFDELLFSAGPREASRSVPDMDLPGASSFYASDWEPLG SQ AGSGGELEPLCTPVVTCTPCPSTYTSTFVFTYPEADAFPSCAAAHRKGSSSNEPSSDSLS SQ SPTLLAL XX SC SwissProt #P11939 XX FF coactivation of ERE (ovalbumin) with c-Jun and estrogen receptor XX IN T00051; ATF; human, Homo sapiens. IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T00209; E1A 13S protein; adenovirus type 2. IN T00436; JunB; mouse, Mus musculus. IN T00437; Jun-D; mouse, Mus musculus. IN T00902; XBP-1; human, Homo sapiens. IN T00967; E1A 12S protein; adenovirus. IN T01303; CREB-2; human, Homo sapiens. IN T01433; MafB; chick, Gallus gallus. XX DR EMBL: Y00659; GDFOS(r). DR EMBL: M18043; GGCFOS(g). DR EMBL: M37000; GGCFOSA(r). DR SwissProt: P11939; FOS_CHICK. DR PIR: A28368; TVCHFS. XX RN [1] RA Saffen D. W., Cole A. J., Worley P. F., Christy B. RA A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor RT messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [2] RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate RT distinct programs of early response gene expression: RT dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [3] RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription RT factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [4] RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate RT in transcriptional activation in an interdependent manner RL New Biologist 1:35-43 (1989). RN [5] RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., RA Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation RT of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [6] RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity RT is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [7] RA Hoffman E. C., Reyes H., Chu F.-F., Sander F., Conley RA H., Brooks B. A., Hankinson O. RT Cloning of a factor required for activity of the Ah (dioxin) receptor RL Science 252:954-958 (1991). RN [8] RA Herbst R. S., Boczo E. M., Darnell J. E., Babiss L. E. RT The louse albumin enhancer contains a negative regulatory RT element that interacts with a novel DNA-binding protein RL Mol. Cell. Biol. 10:3896-3905 (1990). RN [9] RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [10] RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus RT enhancer are independently the targets of stimulation RT by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate RT and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [11] RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor RT involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [12] RA Gius D., Cao X., Rauscher III. F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are RT Independent Functions: The C Terminus Represses Immediate-Early RT Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). XX // AC T00126 XX ID T00126 XX DT 15.10.92 (created); ewi. XX FA CG-1 XX SY USF; XX OS tobacco, Nicotiana tabacum OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC asteridae; solanes; solanaceae XX FF also found in A. majus, Petunia hybrida, Arabidopsis thaliana, Glycine max. XX BS R00992; AD$MLP_07; Quality: 6; adenovirus BS R01738; AM$CHS_01; Quality: 6; garden snapdragon, Antirrhinum majus BS R01740; NT$RS_01; Quality: 6; tobacco, Nicotiana tabacum BS R01739; PARS$CHS_01; Quality: 6; parsley, Petroselium crispum XX RN [1] RA Staiger D., Kaulen H., Schell J. RT A CACGTG motif of the Antirrhinum majus chalcone synthase RT promoter is recognized by an evolutionarily conserved nuclear protein RL Proc. Natl. Acad. Sci. USA 86:6930-6934 (1989). XX // AC T00127 XX ID T00127 XX DT 23.03.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CHOP-10 XX SY GADD 153 (hamster); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.3.0.6. XX SZ 168 AA; 19 kDa (cDNA), 29 kDa (SDS) XX SQ MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL SQ AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK SQ EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA XX SC SwissProt #P35639 XX FT 100 129 variant basic region FT 133 154 variant leucine zipper (L3T) XX CP liver enriched XX FF inhibits DNA-binding of C/EBPalpha or C/EBPbeta [1]; XX IN T00017; C/EBPbeta; mouse, Mus musculus. IN T00104; C/EBPalpha; mouse, Mus musculus. IN T00105; C/EBPalpha; human, Homo sapiens. IN T00106; C/EBP; fruit fly, Drosophila melanogaster. IN T00107; C/EBPalpha; chick, Gallus gallus. IN T00108; C/EBPalpha; rat, Rattus norvegicus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. IN T00581; C/EBPbeta; human, Homo sapiens. IN T01386; C/EBP; Aplysia, Aplysia californica. IN T01388; C/EBP; clawed frog, Xenopus laevis. XX MX M00249; V$CHOP_01 XX DR EMBL: X67083; MMCHOP10(r). DR SwissProt: P35639; CHOP_MOUSE. XX RN [1] RA Ron D., Habener J. F. RT CHOP, a novel developmentally regulated nuclear protein RT that dimerizes with transcription factors C/EBP and RT LAP and functions as a dominant-negative inhibitor of gene transcription RL Genes Dev. 6:439-453 (1992). XX // AC T00128 XX ID T00128 XX DT 14.05.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA HOXA4 XX SY Chox-1.4; Chox1.4; Hox-1.4 (mouse); XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX HO Dfd (Drosophila) XX CL C0006; homeo; 3.1.1.2.12. XX SZ 309 AA; 33.5 kDa (cDNA) XX SQ MTMSSFLINSNYIEPKFPPCEEYTQHSGSAGSSASYHPHHPHPHAPPPPPPPPPPHLHAA SQ HPGPALPEYFPRPRREPGYQAPAAPPGPPGPPPEALYPAQAPSYPQAPYSYSSAGSAAPG SQ PEQPPPGASPPPPPPAKGHPGPAQPLLPGHALQRRCEAAPAAGAGTGPGCALLPDKSLPG SQ LKGKEPVVYPWMKKIHVSTVNPNYSGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRI SQ EIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNQPSLGQQQAKAQTQGHPRPLD SQ GAAPNAAAL XX SC SwissProt #P17277 XX FT 38 148 proline-rich region (46/111) FT 188 193 Antp-type hexapeptide FT 209 268 homeo domain XX SF same DNA-binding specificity as Chox-a [1]; SF different consensus sequences for high- and low-affinity binding sites [1]; SF single-site binding has a KD = 0.77 nM [2]; XX FF cell-specific activator (active in an embryonal carcinoma FF cell line, inactive in a liver-derived cell line) [2]; XX BS R00217; CHICK$CHOXA_01; Quality: 2; chick, Gallus gallus BS R00218; CHICK$CHOXA_02; Quality: 2; chick, Gallus gallus BS R00219; CHICK$CHOXA_03; Quality: 2; chick, Gallus gallus BS R00220; CHICK$CHOXA_04; Quality: 2; chick, Gallus gallus BS R00221; CHICK$CHOXA_05; Quality: 2; chick, Gallus gallus BS R00222; CHICK$CHOXA_06; Quality: 2; chick, Gallus gallus BS R00215; CHICK$HOX14_01; Quality: 2; chick, Gallus gallus BS R00216; CHICK$HOX14_02; Quality: 2; chick, Gallus gallus XX DR EMBL: X52670; GGCHOX14(r). DR EMBL: X52747; GGCHX14(r). DR SwissProt: P17277; HXA4_CHICK. DR PIR: A10883; A10883. DR PIR: S09257; S09257. XX RN [1] RA Sasaki H., Yokoyama E., Kuroiwa A. RT Specific DNA binding of the two chicken Deformed family RT homeodomain proteins, Chox-1.4 and Chox-a RL Nucleic Acids Res. 18:1739-1747 (1990). RN [2] RA Sasaki H., Yamamoto M., Kuroiwa A. RT Cell type dependent transcription regulation by chick homeodomain proteins RL Mech. Dev. 37:25-36 (1992). RN [3] RA Scotting P. J., Hewitt M., Keynes R. J. RT Isolation and analysis of chick homeobox cDNA clones RL Nucleic Acids Res. 18:3999-3999 (1990). XX // AC T00129 XX ID T00129 XX DT 14.05.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA HOXB8 XX SY Chox-2.4; Chox2.4; Hox-2.4 (mouse); XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX HO abd-A (Drosophila) XX CL C0006; homeo; 3.1.1.2.24. XX SQ YTDCKLAASGLGEEAESSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLELEKEFLF SQ NPYLTRKRRIEVSR XX SC SwissProt #P23681 XX DR EMBL: X52748; GGCHX24(r). DR SwissProt: P23681; HXB8_CHICK. DR PIR: S10884; S10884. XX RN [1] RA Scotting P. J., Hewitt M., Keynes R. J. RT Isolation and analysis of chick homeobox cDNA clones RL Nucleic Acids Res. 18:3999-3999 (1990). XX // AC T00130 XX ID T00130 XX DT 14.05.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Chox-2.7 XX SY Chox2.7; Hox-2.7 (mouse); XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX SQ MKESRQNSKQKSSSPSTETCSGEKTPPGSSASKRARTAYTSAQLVELEKEFHFNRYLCRP SQ RRVEMANLLNLSERQIKIWFQNRRMKYKKDEKSKGM XX SC SwissProt #P23682 XX DR EMBL: X52749; GGCHX27(r). DR SwissProt: P23682; HXB3_CHICK. DR PIR: S10885; S10885. XX RN [1] RA Scotting P. J., Hewitt M., Keynes R. J. RT Isolation and analysis of chick homeobox cDNA clones RL Nucleic Acids Res. 18:3999-3999 (1990). XX // AC T00131 XX ID T00131 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA c-Jun XX SY JunA; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.1.1.3. XX SZ 334 AA; 35.9 kDa (cDNA), 40 kDa (SDS) XX SQ MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL SQ LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE SQ LHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYSASLHSEPPVYANLSNFNPGA SQ LSSGGGAPSYGAAGLAFPSQPQQQQQPPQPPHHLPQQIPVQHPRLQALKEEPQTVPEMPG SQ ETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELAST SQ ANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF XX SC SwissProt #P05627 XX FT 63 63 Ser-phosphorylation FT 73 73 Ser-phosphorylation XX SF L5 XX FF transcriptional activator; FF significant enhancement of dimerization by Tax; FF phosphorylation at Ser-63/Ser-73 increases trans-activation FF potential and is enhanced by Ha-Ras [10]; XX IN T00051; ATF; human, Homo sapiens. IN T00122; c-Fos; mouse, Mus musculus. IN T00123; c-Fos; human, Homo sapiens. IN T00124; c-Fos; rat, Rattus norvegicus. IN T00125; c-Fos; chick, Gallus gallus. IN T00131; c-Jun; mouse, Mus musculus. IN T00167; CRE-BP1; human, Homo sapiens. IN T00209; E1A 13S protein; adenovirus type 2. IN T00291; Fos-B; mouse, Mus musculus. IN T00292; FraI; mouse, Mus musculus. IN T00333; GR; rat, Rattus norvegicus. IN T00526; MyoD; mouse, Mus musculus. IN T00888; v-Fos; FBR MuLV, FBR murine osteosarcoma virus. IN T00967; E1A 12S protein; adenovirus. IN T01017; CRE-BP2; mouse, Mus musculus. IN T01095; LRF-1; rat, Rattus norvegicus. IN T01208; FraI; rat, Rattus norvegicus. IN T01303; CREB-2; human, Homo sapiens. IN T01308; CRE-BPa; human, Homo sapiens. IN T01313; ATF-3; human, Homo sapiens. XX MX M00041; V$CREBP1CJUN_01 XX BS R03540; AS$AP1_05; Quality: 6 BS R01037; HS$MT2A_08; Quality: 6; human, Homo sapiens BS R01564; HS$VIMEN_01; Quality: 6; human, Homo sapiens BS R04032; MOUSE$CJUN_03; Quality: 1; mouse, Mus musculus BS R01067; MOUSE$M2IAA_01; Quality: 6; mouse, Mus musculus BS R01225; PA$PY_07; Quality: 6; Py, polyoma virus XX DR EMBL: X12761; MMJUN(r). DR EMBL: X12740; MMJUNC(r). DR SwissProt: P05627; AP1_MOUSE. DR PIR: A31345; TVMSJA. DR Compel: C00074 DR Compel: C00075 DR Compel: C00134 DR Compel: C00144 XX RN [1] RA O'Shea E. K., Rutkowski R., Stafford III W. F., Kim P. S. RT Preferential heterodimer formation by isolated leucine RT zippers from Fos and Jun RL Science 245:646-648 (1989). RN [2] RA Schuermann M., Hunter J. B., Henning G., Mueller R. RT Non-leucine residues in the leucine repeats of Fos RT and Jun contribute to the stability and determine RT the specificity of dimerization RL Nucleic Acids Res. 19:739-746 (1991). RN [3] RA Sassone-Corsi P., Lamph W. W., Kamps M., Verma I. M. RT fos-associated cellular p39 is related to nuclear transcription factor AP-1 RL Cell 54:553-560 (1988). RN [4] RA Schuele R., Rangarajan P., Kliewer S., Ransone L. RA J., Bolado J., Yang N., Verma I. M., Evans R. M. RT Functional antagonism between oncoprotein c-Jun and RT the glucocorticoid receptor RL Cell 62:1217-1226 (1990). RN [5] RA Hsu J. C., Laz T., Mohn K. L., Taub R. RT Identification of LRF-1, a leucine-zipper protein RT that is rapidly and highly induced in regenerating liver RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991). RN [6] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [7] RA Maguire K., Shi X.-P., Horikoshi N., Rappaport J., Rosenberg M., Weinmann R. RT Interactions between adenovirus E1A and members of RT the AP-1 family of cellular transcription factors RL Oncogene 6:1417-1422 (1991). RN [8] RA Kataoka K., Noda M., Nishizawa M. RT Maf nuclear oncoprotein recognizes sequences related RT to an AP-1 site and forms heterodimers with both Fos and Jun RL Mol. Cell. Biol. 14:700-712 (1994). RN [9] RA Kouzarides T., Ziff E. RT The role of the leucine zipper in the fos-jun interaction RL Nature 336:646-651 (1988). RN [10] RA Smeal T., Binetruy B., Mercola D., Grover-Bardwick RA A., Heidecker G., Rapp U. R., Karin M. RT Oncoprotein-mediated signalling cascade stimulates RT c-Jun activity by phosphorylation of serines 63 and 73 RL Mol. Cell. Biol. 12:3507-3513 (1992). RN [11] RA Ryseck R.-P., Hirai S.I., Yaniv M., Bravo R. RT Transcriptional activation of c-jun during the G0/G1 RT transition in mouse fibroblasts RL Nature 334:535-537 (1988). RN [12] RA Ryder K., Nathans D. RT Induction of protooncogene c-jun by serum growth factors RL Proc. Natl. Acad. Sci. USA 85:8464-8467 (1988). RN [13] RA Smeal T., Angel P., Meek J., Karin M. RT Different requirements for formation of Jun:Jun and Jun:Fos complexes RL Genes Dev. 3:2091-2100 (1989). RN [14] RA Abate C., Luk D., Curran T. RT Transcriptional regulation by Fos and Jun in vitro: RT Interaction among multiple activator and regulator domains RL Mol. Cell. Biol. 11:3624-3632 (1991). RN [15] RA Adler V., Polotskaya A., Wagner F., Kraft A. S. RT Affinity-purified j-Jun amino-terminal protein kinases RT requires serine/threonine phosphorylation for activity RL J. Biol. Chem. 267:17001-17005 (1992). RN [16] RA van Dam H., Duyndam M., Rottier R., Bosch A., de Vries-Smits RA L., Herrlich P., Zantema A., Angel P., van der Eb A. J. RT Heterodimer formation of cJun and ATF-2 is responsible RT for induction of c-jun by the 243 amin acid adenovirus E1A protein RL EMBO J. 12:479-487 (1993). RN [17] RA Kerppola T. K., Curran T. RT Selective DNA bending by a variety of bZIP proteins RL Mol. Cell. Biol. 13:5479-5489 (1993). RN [18] RA Patel L. R., Curran T., Kerppola T. K. RT Energy transfer analysis of Fos-Jun dimerization and DNA binding RL Proc. Natl. Acad. Sci. USA 91:7360-7364 (1994). RN [19] RA Srinivas S., Schoenthal A., Eckhart W. RT Polymomavirus middle-sizes tumor antigen modulates RT c-Jun phosphorylation and transcriptional activity RL Proc. Natl. Acad. Sci. USA 91:10064-10068 (1994). RN [20] RA Cano E., Hazzalin C. A., Mahadevan L. C. RT Anisomycin-activated protein kinases p45 and p55 but RT not mitogen-activated protein kinases ERK-1 and -2 RT are implicated in the induction of c-fos and c-jun RL Mol. Cell. Biol. 14:7352-7362 (1994). RN [21] RA Binetruy B., Smeal T., Karin M. RT Ha-Ras augments c-Jun activity and stimulates phosphorylation RT of its activation domain RL Nature 351:122-127 (1991). RN [22] RA Castellazzi M., Spyrou G., La Vista N., Dangy J.-P., RA Piu F., Yaniv M., Brun G. RT Overexpression of c-jun, junB, or junD affects cell growth differently RL Proc. Natl. Acad. Sci. USA 88:8890-8894 (1991). RN [23] RA Pulverer B. J., Kyriakis J. M., Avruch J., Nikolakaki E., Woodgett J. R. RT Phosphorylation of c-jun mediated by MAP kinases RL Nature 353:670-674 (1991). RN [24] RA Nakabeppu Y., Nathans D. RT A naturally occurring truncated form of FosB that RT inhibits Fos/Jun transcriptional activity RL Cell 64:751-759 (1991). RN [25] RA Yen J., Wisdom R. M., Tratner I., Verma I. M. RT An alternative spliced form of FosB is a negative RT regulator of transcriptional activation and transformation by Fos proteins RL Proc. Natl. Acad. Sci. USA 8:5077-5081 (1991). RN [26] RA Baichwal V. R., Park A., Tjian R. RT v-Src and EJ Ras alleviate repression of c-jun by a cell-specific inhibitor RL Nature 352:165-168 (1991). RN [27] RA Smeal T., BinJtruy B., Mercola D., Grover-Bardwick RA A., Heidecker G., Rapp U. R., Karin M. RT Oncoprotein-mediated signalling cascade stimulates RT c-Jun activity by phosphorylation of serines 63 and 73 RL Mol. Cell. Biol. 12:3507-3513 (1992). RN [28] RA Abate C., Baker S. J., Lees-Miller S. P., Anderson RA C. W., Marshak D. R., Curran T. RT Dimerization and DNA binding alter phosphorylation of Fos and Jun RL Proc. Natl. Acad. Sci. USA 90:6766-6770 (1993). RN [29] RA Bossy-Wetzel E., Bravo R., Hanahan D. RT Transcription factors JunB and c-Jun are selectively RT up-regulated and functionally implicated in fibrosarcoma development RL Genes Dev. 6:2340-2351 (1992). RN [30] RA Radler-Pohl A., Sachsenmaier C., Gebel S., Auer H.-P., RA Bruder J. T., Rapp U., Angel P., Rahmsdorf H. J., Herrlich P. RT UV-induced activation of AP-1 involves obligatory RT extranuclear steps including Raf-1 kinase RL EMBO J. 12:1005-1012 (1993). RN [31] RA Li L., Chambard J.-C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by RT myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [32] RA Stein B., A. S. Baldwin jr., Ballard D. W., Greene RA W. C., Angel P., Herrlich P. RT Cross-coupling of the NF-6B p65 and Fos/Jun transcription RT factors produces potentiated biological function RL EMBO J. 12:3879-3891 (1993). RN [33] RA Arias J., Alberts A. S., Brindle P., Claret F. X., RA Smeal T., Karin M., Feramisco J., Montminy M. RT Activation of cAMP and mitogen responsive genes relies RT in a common nuclear factor RL Nature 370:226-229 (1994). RN [34] RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M. RT Fos-Jun interaction: mutational analysis of the leucine RT zipper domain of both proteins RL Genes Dev. 3:770-781 (1989). RN [35] RA de Groot R. P., Karperien M., Pals C., Kruijer W. RT Characterization of the mouse junD promoter - high RT basal level activity due to an octamer motif RL EMBO J. 10:2523-2532 (1991). RN [36] RA Lamph W. W., Wamsley P., Sassone-Corsi P., Verma I. M. RT Induction of proto-oncogene JUN/AP-1 by serum and TPA RL Nature 334:629 (1988). RN [37] RA Nakabeppu Y., Ryder K., Nathans D. RT DNA Binding Activities of Three Murine Jun Proteins: Stimulation by Fos RL Cell 55:907-915 (1988). RN [38] RA Saffen D. W., Cole A. J., Worley P. F., Christy B. RA A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor RT messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [39] RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate RT distinct programs of early response gene expression: RT dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [40] RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription RT factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [41] RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate RT in transcriptional activation in an interdependent manner RL New Biologist 1:35-43 (1989). RN [42] RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation RT is due to increased c-Jun transcription RL New Biologist 2:351-361 (1990). RN [43] RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., RA Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation RT of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [44] RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity RT is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [45] RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [46] RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus RT enhancer are independently the targets of stimulation RT by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate RT and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [47] RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor RT involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [48] RA Gius D., Cao X., Rauscher III. F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are RT Independent Functions: The C Terminus Represses Immediate-Early RT Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). XX // AC T00132 XX ID T00132 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA c-Jun XX SY JunA; p39; p39 c-jun; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.1.1.3. XX SZ 334 AA; 36 kDa (cDNA), 39 kDa (SDS) XX SQ MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGNLKPHLRAKNSDL SQ LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE SQ LHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYSASLHSEPPVYANLSNFNPGA SQ LSSGGGAPSYGATGLAFPSQPQQQQQPPQPPHHLPQQIPVQHPRLQALKEEPQTVPEMPG SQ ETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELAST SQ ANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF XX SC SwissProt #P17325 XX FT 63 63 serine-phosphorylation FT 73 73 serine-phosphorylation FT 246 246 serine-phosphorylation XX FF significant enhancement of dimerization by Tax; FF phosphorylation by p34(cdc2), PKC, CK II, pp44(mapk); FF no detectable influence of phosphorylation on either FF DNA-binding, dimerization, or activation [10]; XX IN T00051; ATF; human, Homo sapiens. IN T00122; c-Fos; mouse, Mus musculus. IN T00123; c-Fos; human, Homo sapiens. IN T00124; c-Fos; rat, Rattus norvegicus. IN T00125; c-Fos; chick, Gallus gallus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00167; CRE-BP1; human, Homo sapiens. IN T00209; E1A 13S protein; adenovirus type 2. IN T00291; Fos-B; mouse, Mus musculus. IN T00292; FraI; mouse, Mus musculus. IN T00333; GR; rat, Rattus norvegicus. IN T00888; v-Fos; FBR MuLV, FBR murine osteosarcoma virus. IN T00967; E1A 12S protein; adenovirus. IN T01017; CRE-BP2; mouse, Mus musculus. IN T01095; LRF-1; rat, Rattus norvegicus. IN T01208; FraI; rat, Rattus norvegicus. IN T01303; CREB-2; human, Homo sapiens. IN T01308; CRE-BPa; human, Homo sapiens. IN T01313; ATF-3; human, Homo sapiens. XX MX M00041; V$CREBP1CJUN_01 XX BS R00362; AD$E4_16; Quality: 6; adenovirus type 5 BS R03668; AS$AP1_06; Quality: 6 BS R00592; HS$GHA_02; Quality: 6; human, Homo sapiens BS R03059; HS$STROM_02; Quality: 6; human, Homo sapiens XX DR EMBL: X17215; RNRJG9(r). DR EMBL: X17163; RSJUNAP1(r). DR SwissProt: P17325; AP1_RAT. DR PIR: S12742; S12742. DR PIR: S20028; S20028. DR Compel: C00141 DR Compel: C00142 DR Compel: C00143 XX RN [1] RA Patel L., Abate C., Curan T. RT Altered protein conformation on DNA binding by Fos and Jun RL Nature 347:572-574 (1990). RN [2] RA Turner R., Tjian R. RT Leucine repeats and an adjacent DNA binding domain RT mediate the formation of functional cFos-cJun heterodimers RL Science 243:1689-1694 (1989). RN [3] RA Gentz R., Rauscher III F. J., Abate C., Curan T. RT Parallel association of Fos and Jun leucine zippers RT juxtaposes DNA binding domains RL Science 243:1695-1699 (1989). RN [4] RA Yang-Yen H.-F., Chambard J.-C., Sun Y.-L., Smeal T., RA Schmidt T. J., Drouin J., Karin M. RT Transcriptional interference between c-Jun and the RT glucocorticoid receptor: mutual inhibition of DNA RT binding due to direct protein-protein interaction RL Cell 62:1205-1215 (1990). RN [5] RA Hsu J. C., Laz T., Mohn K. L., Taub R. RT Identification of LRF-1, a leucine-zipper protein RT that is rapidly and highly induced in regenerating liver RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991). RN [6] RA Hai T., Curran T. RT Cross-family dimerization of transcription factors RT Fos/Jun and ATF/CREB alters DNA binding specificity RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991). RN [7] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [8] RA Kouzarides T., Ziff E. RT The role of the leucine zipper in the fos-jun interaction RL Nature 336:646-651 (1988). RN [9] RA Kouzarides T., Ziff E. RT Leucine zippers of fos, jun and GCN4 dictate dimerization RT specificity and thereby control DNA binding RL Nature 340:568-571 (1989). RN [10] RA Baker S. J., Kerppola T. K., Luk D., Vandenberg M. RA T., Marshak D. R., Curran T., Abate C. RT Jun is phosphorylated by several protein kinases at RT the same sites that are modified in serum-stimulated fibroblasts RL Mol. Cell. Biol. 12:4694- 4705 (1992). RN [11] RA Smeal T., Binetruy B., Mercola D., Grover-Bardwick RA A., Heidecker G., Rapp U. R., Karin M. RT Oncoprotein-mediated signalling cascade stimulates RT c-Jun activity by phosphorylation of serines 63 and 73 RL Mol. Cell. Biol. 12:3507-3513 (1992). RN [12] RA Kitabayashi I., Kawakami Z., Chiu R., Ozawa K., Matsuoka RA T., Toyoshima S., Umesono K., Evans R.M., Gachelin G., Yokoyama K. RT Transcriptional regulation of the c-jun gene by retinoic RT acid and E1A during differentiation of F9 cells RL EMBO J. 11:167-175 (1992). RN [13] RA Bengal E., Ransone L., Scharfmann R., Dwarki V. J., RA Tapscott S. J., Weintraub H., Verma I. M. RT Functional antagonism between c-Jun and MyoD proteins: RT a direct physical association RL Cell 68:507-519 (1992). RN [14] RA Naranjo J. R., Mellstroem B., Auwerx J., Mollinedo F., Sassone-Corsi P. RT Unusual c-fos induction upon chromaffin PC12 differentiation RT by sodium butyrate: loss of fos autoregulatory function RL Nucleic Acids Res. 18:3605-3610 (1990). RN [15] RA Kitabayashi I., Saka F., Gachelin G., Yokoyama K. RT Nucleotide sequence of rat c-jun protooncogene RL Nucleic Acids Res. 18:3400-3400 (1990). RN [16] RA Sakai M., Okuda A., Hatayama I., Sato K., Nishi S., Muramatsu M. RT Structure and expression of the rat c-jun messenger RT RNA: tissue distribution and increase during chemical hepatocarcinogenesis RL Cancer Res. 49:5633-5637 (1989). RN [17] RA Abate C., Patel L., Rauscher III F. J., Curran T. RT Redox regulation of Fos and Jun DNA-binding activity in vitro RL Science 249:1157-1161 (1990). RN [18] RA Kerppola T. K., Curran T. RT DNA bending by Fos and Jun: the flexible hinge model RL Science 254:1210-1214 (1991). RN [19] RA Sutherland J. A., Cook A., Bannister A. J., Kouzarides T. RT Conserved motifs in Fos and Jun define a new class of activation domain RL Genes Dev. 6:1810-1819 (1992). RN [20] RA Minden A., Lin A., Smeal T., Derijard B., Cobb M., Davis R., Karin M. RT c-Jun N-terminal phosphorylation correlates with activation RT of the JNK subgroup but not the ERK subgroup of mitogen-activated RT protein kinases RL Mol. Cell. Biol. 14:6683-6688 (1994). RN [21] RA Alberts et al RT - RL Mol. Cell. Biol. 13:2104-2112 (1993). RN [22] RA Smeal T., Binetruy B., Mercola D. A., Birrer M., Karin M. RT Oncogenic and transcriptional cooperation with Ha-Ras RT requires phosphorylation of c-Jun on serines 63 and 73 RL Nature 354:494-496 (1991). RN [23] RA Alani R., Brown P., BinJtruy B., Dosaka H., Rosenberg RA R. K., Angel P., Karin M., Birrer M. J. RT The transactivating domain of the c-Jun proto-oncoprotein RT is required for cotransformation of rat embryo cells RL Mol. Cell. Biol. 11:6286-6295 (1991). RN [24] RA Schuette J., Viallet J., Nau M., Segal S., Fedorko J., Minna J. RT jun-B inhibits and c-fos stimulates the transforming RT and trans-activating activities of c-jun RL Cell 59:987-997 (1989). RN [25] RA Kyriakis J. M., Banerjee P., Nikolakaki E., Dai T., RA Rudie E. A., Ahmad M. F., Avruch J., Woodgett J. R. RT The stress-activated protein kinase subfamily of c-Jun kinases RL Nature 369:156-160 (1994). RN [26] RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity RT is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [27] RA Li L., Chambard J.-C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by RT myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [28] RA Rauscher III. F. J., Voulalas P. J., Franza Jr. B. R., Curran T. RT Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro RL Genes Dev. 2:1687-1699 (1988). RN [29] RA Kerppola T. K., Curran T. RT Fos-Jun heterodimers and Jun homodimers bend DNA in RT opposite orientations: implications for transcription factor cooperativity RL Cell 66:317-326 (1991). RN [30] RA Buttice G., Quinones S., Kurkinen M. RT The AP-1 site is required for basal expression but RT is not necessary for TPA-response of the human stromelysin gene RL Nucleic Acids Res. 19:3723-3731 (1991). RN [31] RA Saffen D. W., Cole A. J., Worley P. F., Christy B. RA A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor RT messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [32] RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate RT distinct programs of early response gene expression: RT dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [33] RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription RT factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [34] RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate RT in transcriptional activation in an interdependent manner RL New Biologist 1:35-43 (1989). RN [35] RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation RT is due to increased c-Jun transcription RL New Biologist 2:351-361 (1990). RN [36] RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., RA Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation RT of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [37] RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity RT is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [38] RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [39] RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus RT enhancer are independently the targets of stimulation RT by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate RT and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [40] RA Gius D., Cao X., Rauscher III. F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are RT Independent Functions: The C Terminus Represses Immediate-Early RT Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). XX // AC T00133 XX ID T00133 XX DT 15.10.92 (created); ewi. DT 20.05.97 (updated); ewi. XX FA c-Jun XX SY AP1; p39; p39-jun; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0008; bZIP; 1.1.1.1.3. XX SZ 331 AA; 35.7 kDa (cDNA); 39 kDa (SDS) XX SQ MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL SQ LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE SQ LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA SQ LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP SQ PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM SQ LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF XX SC SwissProt #P05412 XX SF glutamine-rich region SF the bZP domain targets the second trans-activating SF domain of E2A proteins when repressing their activation potential [49]; XX FF inducible by UV, H2O2; FF inhibits GR; FF significant enhancement of dimerization by Tax; FF DNA-binding is inhibited by RAR, possibly by direct FF interaction through the RAR-DNA binding domain; FF it is also repressed by T3R-alpha; FF inhibition by RAR/T3R is abrogated by v-ErbA; FF enhanced mRNA levels after thrombin treatment, 2 maxima FF after 0.5 and 12h [12]; XX IN T00051; ATF; human, Homo sapiens. IN T00122; c-Fos; mouse, Mus musculus. IN T00123; c-Fos; human, Homo sapiens. IN T00124; c-Fos; rat, Rattus norvegicus. IN T00125; c-Fos; chick, Gallus gallus. IN T00133; c-Jun; human, Homo sapiens. IN T00167; CRE-BP1; human, Homo sapiens. IN T00209; E1A 13S protein; adenovirus type 2. IN T00291; Fos-B; mouse, Mus musculus. IN T00292; FraI; mouse, Mus musculus. IN T00333; GR; rat, Rattus norvegicus. IN T00334; GR; chick, Gallus gallus. IN T00335; GR; mouse, Mus musculus. IN T00336; GR; cat, Felis catus. IN T00337; GR alpha; human, Homo sapiens. IN T00581; C/EBPbeta; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T00888; v-Fos; FBR MuLV, FBR murine osteosarcoma virus. IN T00967; E1A 12S protein; adenovirus. IN T01017; CRE-BP2; mouse, Mus musculus. IN T01082; AS321; human, Homo sapiens. IN T01095; LRF-1; rat, Rattus norvegicus. IN T01208; FraI; rat, Rattus norvegicus. IN T01303; CREB-2; human, Homo sapiens. IN T01308; CRE-BPa; human, Homo sapiens. IN T01313; ATF-3; human, Homo sapiens. IN T01382; CRE-BP2; rat, Rattus norvegicus. IN T01920; GR beta; human, Homo sapiens. XX MX M00041; V$CREBP1CJUN_01 XX BS R00352; AD$E4_06; Quality: 2; adenovirus BS R02963; AS$AP1_02; Quality: 6 BS R03082; AS$AP1_03; Quality: 6 BS R03533; AS$AP1_04; Quality: 6 BS R03910; AS$AP1_07; Quality: 2 BS R03924; AS$AP1_08; Quality: 6 BS R03909; AS$CRE_02; Quality: 2 BS R01195; CHICK$OA_04; Quality: 1; chick, Gallus gallus BS R04112; CRPJUN$CONS_01; Quality: 2 BS R00199; EBV$BZLF1_03; Quality: 6; EBV, Epstein-Barr virus BS R00007; HS$4F2H_03; Quality: 6; human, Homo sapiens BS R04330; HS$ANF_03; Quality: 2; human, Homo sapiens BS R02453; HS$BG_11; Quality: 6; human, Homo sapiens BS R00235; HS$CLASE_01; Quality: 6; human, Homo sapiens BS R04348; HS$CYCD1_01; Quality: 2; human, Homo sapiens BS R04127; HS$ET1_02; Quality: 3; human, Homo sapiens BS R00455; HS$FN_02; Quality: 2; human, Homo sapiens BS R03522; HS$IL2_12; Quality: 6; human, Homo sapiens BS R01037; HS$MT2A_08; Quality: 6; human, Homo sapiens BS R01258; HS$PK_03; Quality: 6; human, Homo sapiens BS R03186; HS$TNFA_01; Quality: 6; human, Homo sapiens BS R01559; HS$VIP_01; Quality: 6; human, Homo sapiens BS R02454; MMTV$MMTV_36; Quality: 6; MMTV, mouse mammary tumor virus BS R03386; MOUSE$JUND_06; Quality: 6; mouse, Mus musculus BS R01285; MOUSE$PLF_01; Quality: 6; mouse, Mus musculus BS R03532; RAT$AFEP_13; Quality: 6; rat, Rattus rattus BS R01358; RAT$SSTA_01; Quality: 6; rat, Rattus norvegicus BS R01383; SV$SV40_15; Quality: 6; SV40, simian virus 40 BS R01384; SV$SV40_16; Quality: 6; SV40, simian virus 40 BS R01394; SV$SV40_26; Quality: 6; SV40, simian virus 40 BS R01412; SV$SV40_44; Quality: 6; SV40, simian virus 40 XX DR EMBL: J04111; HSJUNA(g). DR SwissProt: P05412; AP1_HUMAN. DR PIR: A31264; TVHUJN. DR Compel: C00079 DR Compel: C00080 DR Compel: C00082 DR Compel: C00083 DR Compel: C00092 DR Compel: C00094 DR Compel: C00099 DR Compel: C00138 DR PDB: 1fos; TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES. XX RN [1] RA Turner R., Tjian R. RT Leucine repeats and an adjacent DNA binding domain RT mediate the formation of functional cFos-cJun heterodimers RL Science 243:1689-1694 (1989). RN [2] RA Gentz R., Rauscher III F. J., Abate C., Curan T. RT Parallel association of Fos and Jun leucine zippers RT juxtaposes DNA binding domains RL Science 243:1695-1699 (1989). RN [3] RA Schuele R., Rangarajan P., Kliewer S., Ransone L. RA J., Bolado J., Yang N., Verma I. M., Evans R. M. RT Functional antagonism between oncoprotein c-Jun and RT the glucocorticoid receptor RL Cell 62:1217-1226 (1990). RN [4] RA Yang-Yen H.-F., Chambard J.-C., Sun Y.-L., Smeal T., RA Schmidt T. J., Drouin J., Karin M. RT Transcriptional interference between c-Jun and the RT glucocorticoid receptor: mutual inhibition of DNA RT binding due to direct protein-protein interaction RL Cell 62:1205-1215 (1990). RN [5] RA Hai T., Curran T. RT Cross-family dimerization of transcription factors RT Fos/Jun and ATF/CREB alters DNA binding specificity RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991). RN [6] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [7] RA Schuele R., Rangarajan P., Yang N., Kliewer S., Ransone RA L. J., Bolado J., Verma I. M., Evans R. M. RT Retinoic acid is a negative regulator of AP-1-responsive genes RL Proc. Natl. Acad. Sci. USA 88:6092-6096 (1991). RN [8] RA Desbois C., Aubert D., Legrand C., Pain B., Samarut J. RT A novel mechanism of action for v-erbA: abrogation RT of the inactivation of transcription factor AP-1 by RT retinoic acid and thyroid hormone receptors RL Cell 67:731-740 (1991). RN [9] RA Bohmann D., Bos T. J., Admon A., Nishimura T., Vogt P. K., Tjian R. RT Human proto-oncogene c-jun encodes a DNA binding protein RT with structural and functional properties of transcription factor AP-1 RL Science 238:1386-1392 (1987). RN [10] RA Bohmann D., Tjian R. RT Biochemical analysis of transcriptional activation RT by Jun: Differential activity of c- and v-Jun RL Cell 59:709-717 (1989). RN [11] RA Franza Jr. B. R., Rauscher III F. J., Josephs S. F., Curran T. RT The Fos-complex and Fos-related antigens recognize RT sequence elements that contain AP-2 binding sites RL Science 239:1150-1153 (1988). RN [12] RA Trejo J., Chambard J.-C., Karin M., Brown J. H. RT Biphasic increase in c-jun mRNA is required for induction RT of AP-1-mediated gene transcription: Differential RT effects of muscarinic and thrombin receptor activation RL Mol. Cell. Biol. 12:4742- 4750 (1992). RN [13] RA Hattori K., Angel P., Le Beau M.M., Karin M. RT Structure and chromosomal localization of the functional RT intronless human jun protooncogene RL Proc. Natl. Acad. Sci. USA 85:9148-9152 (1988). RN [14] RA Angel P., Imagawa M., Chiu R., Stein B., Imbra R. RA J., Rahmsdorf H. J., Jonat C., Herrlich P., Karin M. RT Phorbol ester-inducible genes contain a common cis RT element recognized by a TPA-modulated trans-acting factor RL Cell 49:729-739 (1987). RN [15] RA Angel P., Allegretto E. A., Okino S. T., Hattori K., RA Boyle W. J., Hunter T., Karin M. RT Oncogene jun encodes a sequence-specific trans-activator similar to AP-1 RL Nature 332:166-171 (1988). RN [16] RA Mignotte V., Eleouet J. F., Raich N., Romeo P.-H. RT Cis- and trans-acting elements involved in the regulation RT of the erythroid promoter of the human porphobilinogen deaminase gene RL Proc. Natl. Acad. Sci. USA 86:6548-6552 (1989). RN [17] RA Rauscher III F. J., Cohen D. R., Curran T., Bos T. RA J., Vogt P. K., Bohmann D., Tjian R., B. R. Franza jr. RT Fos-associated protein p39 is the product of the jun proto-oncogene RL Science 240:1010-1016 (1988). RN [18] RA Baichwal V. R., Tjian R. RT Control of c-Jun activity by interaction of a cell-specific RT inhibitor with regulatory domain delta: Differences between v- and c-Jun RL Cell 63:815-825 (1990). RN [19] RA Baichwal V. R., Park A., Tjian R. RT The cell-type-specific activator region of c-Jun juxtaposes RT constitutive and negatively regulated domains RL Genes Dev. 6:1493-1502 (1992). RN [20] RA Junius F. K., Weiss A. S., King G. F. RT The solution stucture of the leucine zipper motif RT of the Jun oncoprotein homodimer RL Eur. J. Biochem. 214:415-424 (1993). RN [21] RA van Dam H., Duyndam M., Rottier R., Bosch A., de Vries-Smits RA L., Herrlich P., Zantema A., Angel P., van der Eb A. J. RT Heterodimer formation of cJun and ATF-2 is responsible RT for induction of c-jun by the 243 amin acid adenovirus E1A protein RL EMBO J. 12:479-487 (1993). RN [22] RA Bannister A. J., Gottlieb T. M., Kouzarides T., Jackson S. P. RT c-Jun is phosphorylated by the DNA-dependent protein RT kinase in vitro; definition of the minimal kinase recognition motif RL Nucleic Acids Res. 21:1289-1295 (1993). RN [23] RA Kallunki T., Su B., Tsigelny I., Sluss H. K., Derijard RA B., Moore G., Davis R., Karin M. RT JNK2 contains a specificity-determining region responsible RT for efficient c-Jun binding and phosphorylation RL Genes Dev. 8:2996-3007 (1994). RN [24] RA Treier M., Staszewski L. M., Bohmann D. RT Ubiquitin-dependent c-Jun degradattion in vivo is RT mediated by the delta domain RL Cell 78:787-798 (1994). RN [25] RA Riley L. G., Junius F. K., Swanton M. K., Vesper N. RA A., Williams N. K., King G. F., Weiss A. S. RT Cloning, expression, and spectroscopic studies of RT the Jun leucine zipper domain RL Eur. J. Biochem. 219:877-889 (1994). RN [26] RA Natoli G., Laura M., Avantaggiati , Chirillo P., Costanzo RA A., Artini M., Balsano C., Levrero M. RT Induction of the DNA-binding activity of c-Jun/c-Fos RT heterodimers by the hepatitis B virus transactivator pX RL Mol. Cell. Biol. 14:989-998 (1994). RN [27] RA Minden A., Lin A., Smeal T., Derijard B., Cobb M., Davis R., Karin M. RT c-Jun N-terminal phosphorylation correlates with activation RT of the JNK subgroup but not the ERK subgroup of mitogen-activated RT protein kinases RL Mol. Cell. Biol. 14:6683-6688 (1994). RN [28] RA Binetruy B., Smeal T., Karin M. RT Ha-Ras augments c-Jun activity and stimulates phosphorylation RT of its activation domain RL Nature 351:122-127 (1991). RN [29] RA Pulverer B. J., Kyriakis J. M., Avruch J., Nikolakaki E., Woodgett J. R. RT Phosphorylation of c-jun mediated by MAP kinases RL Nature 353:670-674 (1991). RN [30] RA Xanthoudakis S., Curran T. RT Identification and characterization of Ref-1, a nuclear RT protein that facilitates AP-1 DNA-binding activity RL EMBO J. 11:653-665 (1992). RN [31] RA Baichwal V. R., Park A., Tjian R. RT v-Src and EJ Ras alleviate repression of c-jun by a cell-specific inhibitor RL Nature 352:165-168 (1991). RN [32] RA Schuette J., Viallet J., Nau M., Segal S., Fedorko J., Minna J. RT jun-B inhibits and c-fos stimulates the transforming RT and trans-activating activities of c-jun RL Cell 59:987-997 (1989). RN [33] RA Riabowol K., Schiff J., Gilman M. Z. RT Transcription factor AP-1 activity is required for RT initiation of DNA synthesis and is lost during cellular aging RL Proc. Natl. Acad. Sci. USA 89:157-161 (1992). RN [34] RA Xanthoudakis S., Curran T. RT Redox activation of Fos-Jun DNA binding activity is RT mediated by a DNA repair enzyme RL EMBO J. 11:3323-3335 (1992). RN [35] RA Lin A., Frost J., Deng T., Smeal T., Al-Alawi A., RA Kikkawa U., Hunter T., Brenner D., Karin M. RT Casein kinase II is a negative regulator of c-Jun RT DNA binding and AP-1 activity RL Cell 70:777-789 (1992). RN [36] RA Adler V., Franklin C. C., Kraft A. S. RT Phorbol esters stimulate the phosphorylation of c-Jun RT but not v-Jun: Regulation by the N-terminal delta domain RL Proc. Natl. Acad. Sci. USA 89:5341-5345 (1992). RN [37] RA Radler-Pohl A., Sachsenmaier C., Gebel S., Auer H.-P., RA Bruder J. T., Rapp U., Angel P., Rahmsdorf H. J., Herrlich P. RT UV-induced activation of AP-1 involves obligatory RT extranuclear steps including Raf-1 kinase RL EMBO J. 12:1005-1012 (1993). RN [38] RA Frost J. A., Geppert T. D., Cobb M., Feramisco J. R. RT A requirement for extracellular signal-regulated kinase RT (ERK) function in the activation of AP-1 by Ha-Ras, RT phorbol 12-myristate 13-acetate, and serum RL Proc. Natl. Acad. Sci. USA 91:3844-3848 (1994). RN [39] RA O'Donoghue S. I., Junius F. K., King G. F. RT Determination of the structure of symmetric coiled-coil RT proteins from NMR data: application of the leucine RT zipper proteins Jun and GCN4 RL Protein Engineering 6:557-564 (1993). RN [40] RA Kallunki T., Su B., Tsigelny I., Sluss H. K., Derijard RA B., Moore G., Davis R., Karin M. RT JNK2 contains a specificity-determining region responsible RT for efficient c-Jun binding and phosphorylation RL Genes Dev. 8:2996-3007 (1994). RN [41] RA Li L., Chambard J.-C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by RT myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [42] RA Alvarez E., Northwood I. C., Gonzalez F. A., Latour RA D. A., Seth A., Abate C., Curran T., Davis R. J. RT Pro-Leu-Ser/Thr-Pro is a consensus primary sequence RT for substrate protein phosphorylation. Characterization RT of the phosphorylation of c-myc and c-jun proteins RT by an epidermal growth factor receptor threonine 669 protein kinase RL J. Biol. Chem. 266:15277-15285 (1991). RN [43] RA Papavassiliou A. G., Treier M., Bohmann D. RT Intramolecular signal transduction in c-Jun RL EMBO J. 14:2014-2019 (1994). RN [44] RA Hsu W., Kerppola T. K., Chen P. L., Curran T., Chen-Kiang S. RT Fos and Jun repress transcription activation by NF-IL6 RT through association at the basic zipper region RL Mol. Cell. Biol. 14:268-276 (1994). RN [45] RA Glover J. N. M., Harrison S. C. RT Crystal structure of the heterodimeric bZIP transcription RT factor c-Fos-c-Jun bound to DNA RL Nature 373:257-261 (1995). RN [46] RA Stein B., A. S. Baldwin jr., Ballard D. W., Greene RA W. C., Angel P., Herrlich P. RT Cross-coupling of the NF-6B p65 and Fos/Jun transcription RT factors produces potentiated biological function RL EMBO J. 12:3879-3891 (1993). RN [47] RA Arias J., Alberts A. S., Brindle P., Claret F. X., RA Smeal T., Karin M., Feramisco J., Montminy M. RT Activation of cAMP and mitogen responsive genes relies RT in a common nuclear factor RL Nature 370:226-229 (1994). RN [48] RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M. RT Fos-Jun interaction: mutational analysis of the leucine RT zipper domain of both proteins RL Genes Dev. 3:770-781 (1989). RN [49] RA Robinson G. L. W. G., Henderson E., Massari M. E., Murre C., Stein R. RT c-Jun inhibits insulin control element-mediated transcription RT by affecting the transactivation potential of the E2A gene products RL Mol. Cell. Biol. 15:1398-1404 (1995). RN [50] RA Sharma A., Bos T. J., Pekkala-Flagan A., Vogt P. K., Lee A. S. RT Interaction of cellular factors related to the Jun RT oncoprotein with the promoter of a replication-dependent RT hamster histone H3.2 gene RL Proc. Natl. Acad. Sci. USA 86:491-495 (1989). RN [51] RA Kamata N., Jotte R. M., Holt J. T. RT Myristylation alters DNA-binding activity and transactivation RT of FBR (gag-fos) protein RL Mol. Cell. Biol. 11:765-772 (1991). RN [52] RA Adunyah S. E., Unlap T. M., Wagner F., Kraft A. S. RT Regulation of c-jun expression and AP-1 enhancer activity RT by granulocyte-macrophage colony-stimulating factor RL J. Biol. Chem. 266:5670 (1991). RN [53] RA Devary Y., Gottlieb R. A., Lau L. F., Karin M. RT Rapid and preferential activation of the c-jun gene RT during the mammalian UV response RL Mol. Cell. Biol. 11:2804-2811 (1991). RN [54] RA Fink J. S., Verhave M., Walton K., Mandel G., Goodman R. H. RT Cyclic AMP- and phorbol ester-induced transcriptional RT activation are mediated by the same enhancer element RT in the human vasoactive intestinal peptide gene RL J. Biol. Chem. 266:3882-3887 (1991). RN [55] RA Buttice G., Quinones S., Kurkinen M. RT The AP-1 site is required for basal expression but RT is not necessary for TPA-response of the human stromelysin gene RL Nucleic Acids Res. 19:3723-3731 (1991). RN [56] RA de Groot R. P., Karperien M., Pals C., Kruijer W. RT Characterization of the mouse junD promoter - high RT basal level activity due to an octamer motif RL EMBO J. 10:2523-2532 (1991). RN [57] RA Halazonetis T. D., Georgopoulos K., Greenberg M. E., Leder P. RT c-jun dimerizes with itself and with c-Fos, forming RT complexes of different DNA binding affinities RL Cell 55:917-924 (1988). RN [58] RA Saffen D. W., Cole A. J., Worley P. F., Christy B. RA A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor RT messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [59] RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate RT distinct programs of early response gene expression: RT dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [60] RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription RT factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [61] RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate RT in transcriptional activation in an interdependent manner RL New Biologist 1:35-43 (1989). RN [62] RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation RT is due to increased c-Jun transcription RL New Biologist 2:351-361 (1990). RN [63] RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., RA Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation RT of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [64] RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity RT is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [65] RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H. RT A cDNA for a human cyclic AMP response element-binding RT protein which is distinct from CREB and expressed preferentially in brain RL Mol. Cell. Biol. 10:1347-1357 (1990). RN [66] RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [67] RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus RT enhancer are independently the targets of stimulation RT by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate RT and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [68] RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor RT involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [69] RA Gius D., Cao X., Rauscher III. F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are RT Independent Functions: The C Terminus Represses Immediate-Early RT Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). XX // AC T00134 XX ID T00134 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA c-Jun XX SY JunA; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0008; bZIP; 1.1.1.1.3. XX SZ 310 AA; 33.9 kDa (cDNA), 39 kDa (SDS) XX SQ MEPTFYEDALNASFAPPESGGYGYNNAKVLKQSMTLNLSDAASSLKPHLRNKNADILTSP SQ DVGLLKLASPELERLIIQSSNGLITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHNQ SQ NTLPSVTSAAQPVSGGMAPVSSMAGGGSFNTSLHSEPPVYANLSNFNPNALNSAPNYNAN SQ GMGYAPQHHINPQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMR SQ NRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQ SQ LMLTQQLQTF XX SC SwissProt #P18870 XX FF coactivation of ERE (ovalbumin) with c-Fos and estrogen receptor XX IN T00051; ATF; human, Homo sapiens. IN T00122; c-Fos; mouse, Mus musculus. IN T00123; c-Fos; human, Homo sapiens. IN T00124; c-Fos; rat, Rattus norvegicus. IN T00125; c-Fos; chick, Gallus gallus. IN T00134; c-Jun; chick, Gallus gallus. IN T00167; CRE-BP1; human, Homo sapiens. IN T00209; E1A 13S protein; adenovirus type 2. IN T00291; Fos-B; mouse, Mus musculus. IN T00292; FraI; mouse, Mus musculus. IN T00333; GR; rat, Rattus norvegicus. IN T00888; v-Fos; FBR MuLV, FBR murine osteosarcoma virus. IN T00967; E1A 12S protein; adenovirus. IN T01017; CRE-BP2; mouse, Mus musculus. IN T01095; LRF-1; rat, Rattus norvegicus. IN T01208; FraI; rat, Rattus norvegicus. IN T01308; CRE-BPa; human, Homo sapiens. IN T01313; ATF-3; human, Homo sapiens. XX MX M00041; V$CREBP1CJUN_01 XX BS R00678; HA$H32_01; Quality: 6; hamster XX DR EMBL: M57467; GGJUN(g). DR SwissProt: P18870; AP1_CHICK. XX RN [1] RA Bohmann D., Tjian R. RT Biochemical analysis of transcriptional activation RT by Jun: Differential activity of c- and v-Jun RL Cell 59:709-717 (1989). RN [2] RA Bengal E., Ransone L., Scharfmann R., Dwarki V. J., RA Tapscott S. J., Weintraub H., Verma I. M. RT Functional antagonism between c-Jun and MyoD proteins: RT a direct physical association RL Cell 68:507-519 (1992). RN [3] RA Nishimura T., Vogt P. K. RT The avian cellular homolog of the oncogene jun RL Oncogene 3:659-663 (1988). RN [4] RA Havarstein L. S., Morgan I. M., Wong W.-Y., Vogt P. K. RT Mutations in the Jun Delta region suggest an inverse RT correlation between transformation and transcriptional activation RL Proc. Natl. Acad. Sci. USA 89:618-622 (1992). RN [5] RA Baichwal V. R., Park A., Tjian R. RT v-Src and EJ Ras alleviate repression of c-jun by a cell-specific inhibitor RL Nature 352:165-168 (1991). RN [6] RA Hibi M., Lin A., Smeal T., Minden A., Karin M. RT Idnetification of an oncoprotin- and UV-responsive RT protein kinase that binds and potentiates the c-Jun activation domain RL Genes Dev. 7:2135-2148 (1993). RN [7] RA Monteclard F. S., Vogt P. K. RT A Jun-binding protein related to a putative tumor suppressor RL Proc. Natl. Acad. Sci. USA 90:6726-6730 (1993). RN [8] RA Sharma A., Bos T. J., Pekkala-Flagan A., Vogt P. K., Lee A. S. RT Interaction of cellular factors related to the Jun RT oncoprotein with the promoter of a replication-dependent RT hamster histone H3.2 gene RL Proc. Natl. Acad. Sci. USA 86:491-495 (1989). RN [9] RA Saffen D. W., Cole A. J., Worley P. F., Christy B. RA A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor RT messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [10] RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate RT distinct programs of early response gene expression: RT dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [11] RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription RT factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [12] RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate RT in transcriptional activation in an interdependent manner RL New Biologist 1:35-43 (1989). RN [13] RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation RT is due to increased c-Jun transcription RL New Biologist 2:351-361 (1990). RN [14] RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., RA Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation RT of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [15] RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity RT is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [16] RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [17] RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus RT enhancer are independently the targets of stimulation RT by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate RT and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [18] RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor RT involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [19] RA Gius D., Cao X., Rauscher III. F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are RT Independent Functions: The C Terminus Represses Immediate-Early RT Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). XX // AC T00135 XX ID T00135 XX DT 15.10.92 (created); ewi. XX FA c-Jun XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX SZ 43 kDa (SDS) XX IN T00051; ATF; human, Homo sapiens. IN T00122; c-Fos; mouse, Mus musculus. IN T00123; c-Fos; human, Homo sapiens. IN T00124; c-Fos; rat, Rattus norvegicus. IN T00125; c-Fos; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T00167; CRE-BP1; human, Homo sapiens. IN T00209; E1A 13S protein; adenovirus type 2. IN T00291; Fos-B; mouse, Mus musculus. IN T00292; FraI; mouse, Mus musculus. IN T00333; GR; rat, Rattus norvegicus. IN T00888; v-Fos; FBR MuLV, FBR murine osteosarcoma virus. IN T00967; E1A 12S protein; adenovirus. IN T01017; CRE-BP2; mouse, Mus musculus. IN T01095; LRF-1; rat, Rattus norvegicus. IN T01208; FraI; rat, Rattus norvegicus. IN T01303; CREB-2; human, Homo sapiens. IN T01308; CRE-BPa; human, Homo sapiens. IN T01313; ATF-3; human, Homo sapiens. XX RN [1] RA Sharma A., Bos T. J., Pekkala-Flagan A., Vogt P. K., Lee A. S. RT Interaction of cellular factors related to the Jun RT oncoprotein with the promoter of a replication-dependent RT hamster histone H3.2 gene RL Proc. Natl. Acad. Sci. USA 86:491-495 (1989). XX // AC T00136 XX ID T00136 XX DT 26.01.93 (created); hse. XX FA c-Myb XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 75 kDa (SDS) XX CP haematopoietic system, tumor cell lines XX BS R02206; MYB$CONS_01; Quality: 6 XX RN [1] RA Ness S. A., Marknell A., Graf T. RT The v-myb oncogene product binds to and activates RT the promyelocyte-specific mim-1 gene RL Cell 59:1115-1125 (1989). RN [2] RA Howe K. M., Reakes C. F. L., Watson R. J. RT Characterization of the sequence-specific interaction RT of mouse c-myb protein with DNA RL EMBO J. 9:161-169 (1990). RN [3] RA Biedenkapp H., Borgmeyer U., Sippel A., Klempnauer K.-H. RT Viral myb oncogene encodes a sequence-specific DNA-binding activity RL Nature 335:835-837 (1988). RN [4] RA Luescher B., Eisenman R. N. RT New light on Myc and Myb. part II. Myb RL Genes Dev. 4:2235-2241 (1990). XX // AC T00137 XX ID T00137 XX DT 26.01.93 (created); hse. DT 14.02.97 (updated); ewi. XX FA c-Myb XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0022; trp; 3.5.1.1.1. XX SZ 640 AA; 72.5 kDa (cDNA), 75 kDa (SDS) XX SQ MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT SQ DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK SQ HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA SQ IKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV SQ NNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL SQ LLMSTENELKGQQVLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPAD SQ PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLT SQ STPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIK SQ YGPLKMLPQTPSHLVEDLQDVIKQESDESGFVAEFQENGPPLLKKIKQEVESPTDKSGNF SQ FCSHHWEGDSLNTQLFTQTSPVRDAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASP SQ LQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM XX SC SwissProt #P10242 XX FT 34 86 basic DNA-binding repeat 1 FT 43 82 tryptophan cluster (W-X19-W-X18-W) FT 87 138 basic DNA-binding repeat 2 FT 95 134 tryptophan cluster (W-X19-W-X18-W) FT 139 189 basic DNA-binding repeat 3 FT 147 185 tryptophan cluster (W-X18-W-X18-W) FT 275 325 transcription activation domain [12]; FT 375 403 putative leucine zipper (MIL3) XX SF C-terminal inhibitory domain, involving the leucine SF zipper motif which can act on the activating domain SF in cis and in trans [12], [10]; XX CP haematopoietic system, tumor cell lines XX FF enhances DNA polymerase alpha expression in T lymphocytes; FF required for G1/S transition [7]; FF expression of the c-myb gene is enhanced by c-Jun FF and JunD, but not JunB, through an AP-1 element [4], FF but also by autostimulation through multiple binding sites [2]; XX BS R04340; HS$CDC2_03; Quality: 2; human, Homo sapiens BS R04341; HS$CDC2_04; Quality: 2; human, Homo sapiens BS R04082; HS$CMYB_01; Quality: 4; human, Homo sapiens BS R04174; HS$PR264_01; Quality: 2; human, Homo sapiens BS R04175; HS$PR264_02; Quality: 2; human, Homo sapiens BS R04176; HS$PR264_03; Quality: 2; human, Homo sapiens BS R04177; HS$PR264_04; Quality: 2; human, Homo sapiens BS R04178; HS$PR264_05; Quality: 2; human, Homo sapiens BS R04179; HS$PR264_06; Quality: 2; human, Homo sapiens BS R04180; HS$PR264_07; Quality: 2; human, Homo sapiens BS R04181; HS$PR264_08; Quality: 2; human, Homo sapiens BS R04182; HS$PR264_09; Quality: 2; human, Homo sapiens BS R04183; HS$PR264_10; Quality: 2; human, Homo sapiens BS R04184; HS$PR264_11; Quality: 2; human, Homo sapiens BS R02206; MYB$CONS_01; Quality: 6 XX DR EMBL: M13665; HSCMYBA(r). DR EMBL: M13666; HSCMYBB(r). DR EMBL: M15024; HSCMYBLA(r). DR SwissProt: P10242; MYB_HUMAN. DR PIR: A26661; TVHUMB. DR Compel: C00003 XX RN [1] RA Ness S. A., Marknell A., Graf T. RT The v-myb oncogene product binds to and activates RT the promyelocyte-specific mim-1 gene RL Cell 59:1115-1125 (1989). RN [2] RA Nicolaides N. C., Gualdi R., Casadevall C., Manzella L., Calabretta B. RT Positive autoregulation of c-myb expression via Myb RT binding sites in the 5 flanking region of the human c-myb gene RL Mol. Cell. Biol. 11:6166-6176 (1991). RN [3] RA Sureau A., Soret J., Vellard M., Crochet J., Perbal B. RT The PR264/c-myb connection: Expression of a splicing RT factor modulated by a nuclear protooncogene RL Proc. Natl. Acad. Sci. USA 89:11683-11687 (1992). RN [4] RA Nicolaides N. C., Correa I., Casadevall C., Travali RA S., Soprano K. J., Calabretta B. RT The jun family members, c- Jun and JunD, transactivate RT the human c-myb promoter via an Ap1-like element RL J. Biol. Chem. 267:19665-19672 (1992). RN [5] RA Slamon D. J., Boone T. C., Murdock D. C., Keith D. RA E., Press M. F., Larson R. A., Souza L. M. RT Studies of the human c-myb gene and its product in human acute leukemias RL Science 233:347-351 (1986). RN [6] RA Majello B., Kenyon L. C., Dalla-Favera R. RT Huamn c-myb protooncogene: Nucleotide sequence of RT cDNA and organization of the genomic locus RL Proc. Natl. Acad. Sci. USA 83:9636-9640 (1986). RN [7] RA Venturelli D., Travali S., Calabretta B. RT Inhibition of T-cell proliferation by a myb antisense RT oligomer is accompanied by selective down-regulation RT of DNA polymerase alpha expression RL Proc. Natl. Acad. Sci. USA 87:5963-5967 (1990). RN [8] RA Frampton F., Leutz A., Gibson T., Graf T. RT DNA-binding domain ancestry RL Nature 342:134- (1989). RN [9] RA Ku D.-H., Wen S.-C., Engelhard A., Nicolaides N. C., RA Lipson K. E., Marino T. A., Calabretta B. RT c-myb transactivates cdc2 expression via myb binding RT sites in the 5'-flanking region of the human cdc2 gene RL J. Biol. Chem. 268:2255-2259 (1993). RN [10] RA Vorbrueggen G., Kalkbrenner F., Guehmann S., Moelling K. RT The carboxyterminus of human c-myb protein stimulates RT activated transcription in trans RL Nucleic Acids Res. 22:2466-2475 (1994). RN [11] RA Luescher B., Eisenman R. N. RT New light on Myc and Myb. part II. Myb RL Genes Dev. 4:2235-2241 (1990). RN [12] RA Kalkbrenner F., Guehmann St., Moelling K. RT Transcriptional activation by human c-myb and v-myb genes RL Oncogene 5:657-661 (1990). XX // AC T00138 XX ID T00138 XX DT 15.10.92 (created); ewi. DT 14.02.97 (updated); ewi. XX FA c-Myb XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0022; trp; 3.5.1.1.1. XX SZ 636 AA; 71.5 kDa (cDNA), 75 kDa (SDS) XX SQ MARRPRHSIYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT SQ DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK SQ HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA SQ IKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNNHLMGFGHASPPSQLSPSGQSSV SQ NSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL SQ LLMSTENELKGQQALPTQNHTCSYPGWHSTSIVDQTRPHGDSAPVSCLGEHHATPSLPAD SQ PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHESSGLDAPTLP SQ STPLIGHKLTPCRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPL SQ KMLPQTPSHAVEDLQDVIKRESDESGIVAEFQESGPPLLKKIKQEVESPTEKSGNFFCSN SQ HWAENSLSTQLFSQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPC SQ SGAWEPASCGKTEDQMTASGPARKYVNAFSARTLVM XX SC SwissProt #P06876 XX FT 34 86 basic DNA-binding repeat 1 FT 43 82 tryptophan cluster (W-X19-W-X18-W) FT 87 138 basic DNA-binding repeat 2 FT 95 134 tryptophan cluster (W-X19-W-X18-W) FT 139 189 basic DNA-binding repeat 3 FT 147 185 tryptophan cluster (W-X18-W-X18-W) FT 275 325 transcription activation domain [16]; FT 375 403 putative leucine zipper (MIL3) XX SF NMR with third repeat: three alpha-helices, helix SF 2 and 3 forming a helix-turn-helix motif [26], [12]; SF the turn is 1 AA longer than in the homeo domain or SF in prokaryotic repressors [12]; SF helix 1 and 2 are nearly parallel, helix 3 nearly perpendicular [12]; SF hydrophobic core of conserved tryptophans and histidine SF residues 159 and 184 [12]; SF within the ideal recognition sequence AACTGAC, helix SF 3 of repeat 3 contacts AAC, helix 3 of repeat 2 GAC, SF both through the major groove [12]; SF repeat 1 contributes to the overall stability [14]; SF slightly acidic trans-activation domain [16]; SF inhibitory C-terminal domain, acting in is and in trans [16]; SF inhibition involves the leucine zipper [21], [4]; XX FF transcriptional activator [20], [10], [18]; FF product of a proto-oncogene involved in hemopoiesis, FF growth regulation and differentiation; FF regulation of transcription of c-myb gene involves FF premature termination within the first intron [15]; XX IN T00138; c-Myb; mouse, Mus musculus. XX MX M00004; V$CMYB_01 XX BS R02603; AS$CMYB_01; Quality: 6 BS R02604; AS$CMYB_02; Quality: 6 BS R02100; CHICK$MIM1_04; Quality: 1; chick, Gallus gallus BS R02392; HIV1$HIV1_17; Quality: 1; HIV-1, human immunodeficiency virus type 1 BS R03999; HT1$HTLV1_21; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R04000; HT1$HTLV1_22; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R04001; HT1$HTLV1_23; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R04002; HT1$HTLV1_24; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R02206; MYB$CONS_01; Quality: 6 BS R03185; MYB$CONS_02; Quality: 6 BS R01847; SV$SV40_55; Quality: 5; SV40, simian virus 40 BS R01848; SV$SV40_56; Quality: 5; SV40, simian virus 40 BS R01849; SV$SV40_57; Quality: 1; SV40, simian virus 40 XX DR EMBL: X04099; MMCMYB1(g). DR EMBL: X04100; MMCMYB2(g). DR EMBL: X04101; MMCMYB3(g). DR EMBL: X04102; MMCMYB4(g). DR EMBL: X04103; MMCMYB5(g). DR EMBL: X04104; MMCMYB6(g). DR EMBL: X16389; MMCMYBE1(g). DR EMBL: X16390; MMCMYBE2(g). DR EMBL: X02774; MMCMYBR(r). DR EMBL: M21169; MMMYBG01(g). DR EMBL: M12848; MMMYBM(r). DR SwissProt: P06876; MYB_MOUSE. DR PIR: A23939; TVMSM3. DR PIR: A93084; TVMSMA. DR PIR: A25285; TVMSMB. DR PIR: A28013; TVMSMY. DR PDB: 1mbe; MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 1. DR PDB: 1mbf; MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 1. DR PDB: 1mbg; MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2. DR PDB: 1mbj; MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3. DR PDB: 1mbk; MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3. XX RN [1] RA Ness S. A., Marknell A., Graf T. RT The v-myb oncogene product binds to and activates RT the promyelocyte-specific mim-1 gene RL Cell 59:1115-1125 (1989). RN [2] RA Dasgupta P., Reddy C. D., Saikumar P., Reddy E. P. RT The cellular proto-oncogene product Myb acts as transcriptional RT activator of the long terminal repeat of human T-lymphotropic virus type I RL J. Virol. 66:270-276 (1992). RN [3] RA Siu G., Wurster A. L., Lipsick J. S., Hedrick S. M. RT Expression of the CD4 gene requires a Myb transcription factor RL Mol. Cell. Biol. 12:1592-1604 (1992). RN [4] RA Nomura T., Sakai N., Sarai A., Sudo T., Kanei-Ishii RA C., Ramsay R. G., Favier D., Gonda T. J., Ishii S. RT Negative autoregulation of c-Myb activity by homodimer RT formation through the leucine zipper RL J. Biol. Chem. 268:21914-21923 (1993). RN [5] RA Lavu S., Reddy E. P. RT Structural organization and nucleotide sequence of RT mouse c-myb oncogene: activation in ABPL tumors is RT due to viral integration in an intron which results RT in the deletion of the 5' coding sequences RL Nucleic Acids Res. 14:5309-5320 (1986). RN [6] RA Bender T. P., Kuehl W. M. RT Murine myb protooncogene mRNA: cDNA sequence and evidence RT for 5' heterogenity RL Proc. Natl. Acad. Sci. USA 83:3204-3208 (1986). RN [7] RA Watson R. J., Dyson P. J., McMahon J. RT Multiple c-myb transcript cap sites are variously RT utilized in cells of mouse haemopoietic origin RL EMBO J. 6:1643-1651 (1987). RN [8] RA Sobieszczuk P. W., Gonda T. J., Dunn A. R. RT Structure and biological activity of the transcriptional RT initiation sequences of the murine c-myb oncogene RL Nucleic Acids Res. 17:9593-9611 (1989). RN [9] RA Gonda T. J., Gough N. M., Dunn A. R., de Blaquire J. RT Nucleotide sequence of cDNA clones of the murine myb proto-oncogene RL EMBO J. 4:2003-2008 (1985). RN [10] RA Nishina Y., Nakagoshi H., Imamoto F., Gonda T. J., Ishii S. RT Trans-activation by the c-myb proto-oncogene RL Nucleic Acids Res. 17:107-117 (1989). RN [11] RA Evans J. L., Moore T. L., Kuehl W. M., Bender T., Ting J. P.-Y. RT Functional analysis of c-myb protein in T-lymphocytic RT cell lines shows that it trans-activates the c-myb promoter RL Mol. Cell. Biol. 10:5747-5752 (1990). RN [12] RA Ogata K., Hojo H., Aimoto S., Nakai T., Nakamura H., RA Sarai A., Ishii S., Nishimura Y. RT Solution structure of DNA binding unit of myb: a helix-turn-helix-related RT motif with conserved tryptophans forming a hydrophobic core RL Proc. Natl. Acad. Sci. USA 89:6428-6432 (1992). RN [13] RA Frampton F., Leutz A., Gibson T., Graf T. RT DNA-binding domain ancestry RL Nature 342:134- (1989). RN [14] RA Tanikawa J., Yasukawa T., Enari M., Ogata K., Nishimura RA Y., Ishii S., Sarai A. RT Recognition of specific DNA sequences by the c-myb RT protooncogene product: role of the three repeat units RT in the DNA-binding domain RL Proc. Natl. Acad. Sci. USA 90:9320-9324 (1993). RN [15] RA Reddy C. D., Reddy E. P. RT Differential binding of nuclear factors to the intron RT 1 sequences containing the transcriptional pause site RT correlates with c-myb expression RL Proc. Natl. Acad. Sci. USA 86:7326-7330 (1989). RN [16] RA Sakura H., Kanei-Ishii C., Nagase T., Nakagoshi H., Gonda T. J. RT Delineation of three functional domains of the transcriptional RT activator encoded by the c-myb protooncogene RL Proc. Natl. Acad. Sci. USA 86:5758-5762 (1989). RN [17] RA Howe K. M., Reakes C. F. L., Watson R. J. RT Characterization of the sequence-specific interaction RT of mouse c-myb protein with DNA RL EMBO J. 9:161-169 (1990). RN [18] RA Nakagoshi H., Nagase T., Kanei-Ishii C., Ueno Y., Ishii S. RT Binding of the c-myb proto-oncogene product to the RT simian virus 40 enhancer stimulates transcription RL J. Biol. Chem. 265:3479-3483 (1990). RN [19] RA Howe K. M., Watson R. J. RT Nucleotide preferences in sequence-specific recognition RT of DNA by c-myb protein RL Nucleic Acids Res. 19:3913-3919 (1991). RN [20] RA Biedenkapp H., Borgmeyer U., Sippel A., Klempnauer K.-H. RT Viral myb oncogene encodes a sequence-specific DNA-binding activity RL Nature 335:835-837 (1988). RN [21] RA Kanei-Ishii C., MacMillan E. M., Nomura T., Sarai RA A., Ramsay R. G., Aimoto S., Ishii S., Gonda Th. J. RT Transactivation and transformation by Myb are negatively RT regulated by a leucine-zipper structure RL Proc. Natl. Acad. Sci. USA 89:3088-3092 (1992). RN [22] RA Luescher B., Eisenman R. N. RT New light on Myc and Myb. part II. Myb RL Genes Dev. 4:2235-2241 (1990). RN [23] RA Dudek H., Tantravahi R. V., Rao V. N., Reddy E. Sh., Reddy E. P. RT Myb and Ets proteins cooperate in transcriptional RT activation of the mim-1 promoter RL Proc. Natl. Acad. Sci. USA 89:1291-1295 (1992). RN [24] RA Gewirtz A. M., Anfossi G., Venturelli D., Valpreda RA S., Sims R., Calabretta B. RT G1/S Transition in normal human T-lymphocytes requires RT the nuclear protein encoded by c-myb RL Science 245:180-183 (1989). RN [25] RA Carr M. D., Mott R. F. RT The transcriptional control proteins c-Myb and v-Myb RT contain a basic region DNA binding motif RL FEBS Lett. 282:293-294 (1991). RN [26] RA Kanei-Ishii Ch., Sarai A., Sawazaki T., Nakagoshi RA H., He D.-N., Ogata K., Nishimura Y., Ishii Sh. RT The Tryptophan cluster: A hypothetical structure of RT the DNA-binding domain of the myb protooncogene product RL J. Biol. Chem. 265:19990-19995 (1990). RN [27] RA Mucenski M. L., McLain K., Kier A. B., Swerdlow S. RA H., Schreiner C. M., Miller Th. A., Pietryga D. W., RA Scott Jr. W. J., Potter S. S. RT A functional c-myb gene is required for normal murine RT fetal hepatic hematopoiesis RL Cell 65:677-689 (1991). RN [28] RA Punyammalee B., Crabell M., de Lannoy C., Perbal B., Glansdorff N. RT Two c-myb proteins differing by their aminotermini RT exhibit different transcriptional transactivation activities RL Oncogene 6:11-19 (1991). RN [29] RA Saikumar P., Murali R., Reddy E. P. RT Role of tryptophan repeats and flanking amino acids in Myb-DNA interaction RL Proc. Natl. Acad. Sci. USA 87:8452-8456 (1990). XX // AC T00139 XX ID T00139 XX DT 26.01.93 (created); hse. DT 27.08.96 (updated); ewi. XX FA c-Myb XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0022; trp; 3.5.1.1.1. XX SZ 641 AA; 72.5 kDa (cDNA), 75 kDa (SDS) XX SQ MARRPRHSIYSSDDDEEDVEMYDHDYDGLLPKAGKRHLGKTRWTREEDEKLKKLVEQNGT SQ EDWKVIASFLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK SQ HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA SQ IKNHWNSTMRRKVEQEGYLQESSKAGLPSATTGFQKSSHLMAFAHNPPAGPLPGAGQAPL SQ GSDYPYYHIAEPQNVPGQIPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL SQ LLMSTENELKGQQALPTQNHTANYPGWHSTTVADNTRTSGDNAPVSCLGEHHHCTPSPPV SQ DHGCLPEESASPARCMIVHQSNILDNVKNLLEFAETLQLIDSFLNTSSNHENLNLDNPAL SQ TSTPVCGHKMSVTTPFHRDQPFKTQKENHVFRTPAIKRSILESSPRTPTPFKNALAAQEI SQ KYGPLKMLPQTPTHLVEDLQDVIKQESEESAIVAGLHESGPPLLKKIKQEVESPTDKAGN SQ FFCSNHWEGENLNTQLFTHASTMEDVPNLLTSSILKMPVSEEEGSFHKAFAVPRNRPLAS SQ PMQHLNNAWESASCGKTEDQMALTDQARKYMAAFPTRTLVM XX SC SwissProt #P01103 XX FT 34 86 basic DNA-binding repeat 1 FT 43 82 tryptophan cluster (W-X19-W-X18-W) FT 87 138 basic DNA-binding repeat 2 FT 95 134 tryptophan cluster (W-X19-W-X18-W) FT 139 189 basic DNA-binding repeat 3 FT 147 185 tryptophan cluster (W-X18-W-X18-W) FT 275 325 transcription activation domain [18]; FT 376 404 putative leucine zipper (MIL3) XX SF three imperfect repeats of 51-52 AA, the 2nd and 3rd SF being essential for specific DNA-binding [16], [1], [6]; SF NMR with repeat 3: three alpha-helices, helix 2 and SF 3 form a helix-turn-helix structure [12]; SF repeat 2: only helices 1 and 2, helix 3 is disordered, SF but is alpha-helically folded upon DNA-binding [12]; SF slightly acidic trans-activation domain [18]; SF oncogenic variants are frequently truncated by repeat 1 [6]; SF inhibitory region within the C-terminal part, able SF to act in cis and trans [8]; SF the leucine zipper has the potential to adopt alpha-helical SF conformation [15]; XX CP haematopoietic system, tumor cell lines XX FF DNA-binding is repressed after phosphorylation of FF Ser-11 and Ser-12 by casein kinase II or related enzymes [6]; FF phosphorylation sites are missing in oncogenic variants [6]; FF possible redox control through Cys-130: oxidation FF reduces DNA-binding affinity [13]; XX IN T00139; c-Myb; chick, Gallus gallus. XX BS R02206; MYB$CONS_01; Quality: 6 XX DR EMBL: M35509; GGCMYBA4(g). DR EMBL: X12495; GGCMYBE1(g). DR EMBL: X03477; GGCMYBR(r). DR EMBL: M14129; GGMYBPO(r). DR SwissProt: P01103; MYB_CHICK. DR PIR: A25075; TVCHM. DR PDB: 1pom; C-MYB PROTO-ONCOGENE (DNA-BINDING DOMAIN REPEAT 3) CHICKEN. XX RN [1] RA Ness S. A., Marknell A., Graf T. RT The v-myb oncogene product binds to and activates RT the promyelocyte-specific mim-1 gene RL Cell 59:1115-1125 (1989). RN [2] RA Urbanek P., Dvorak M., Bartunek P., Pecenka V., Paces V., Travnicek M. RT Nucleotide sequence of chicken myb proto-oncogene RT promoter region: detection of an evolutionarily conserved element RL Nucleic Acids Res. 16:11521-11530 (1988). RN [3] RA Soret J., Vellard M., Martinerie C., Perbal B. RT Organization of 5'-proximal c-myb exons in chicken RT DNA: Implications for c-myb tissue-specific transcription RL FEBS Lett. 232:227-234 (1988). RN [4] RA Rosson D., Reddy P. RT Nucleotide sequence of chicken c-myb complementary RT DNA and implications for myb oncogene activation RL Nature 319:604-606 (1986). RN [5] RA Gerondakis S., Bishop J. M. RT Structure of the protein encoded by the chicken protooncogene c-myb RL Mol. Cell. Biol. 6:3677-3684 (1986). RN [6] RA LĘscher B., Christenson E., Lichtfield D. W., Krebs E. G., Eisenman R. N. RT Myb DNA binding inhibited by phosphorylation at a RT site deleted during oncogenic activation RL Nature 344:517-522 (1990). RN [7] RA Anton I. A., Frampton J. RT Tryptophans in myb proteins RL Nature 336:719- (1988). RN [8] RA Dubendorff J. W., Whittaker L. J., Eltman J. T., Lipsick J. S. RT Carboxy-terminal elements of c-myb negatively regulate RT transcriptional activation in cis and trans RL Genes Dev. 6:2524-2535 (1992). RN [9] RA Weston K. RT Extension of the DNA binding consensus of the chicken RT c-myb and v-myb proteins RL Nucleic Acids Res. 20:3043-3049 (1992). RN [10] RA Frampton F., Leutz A., Gibson T., Graf T. RT DNA-binding domain ancestry RL Nature 342:134- (1989). RN [11] RA Gabrielsen O. S., Sentenac A., Fromageot P. RT Specific DNA-binding by c-myb: evidence for a double RT helix-turn-helix-related motif RL Science 253:1140-1143 (1991). RN [12] RA Jamin N., Gabrielsen O. S., Gilles N., Toma F. RT Secondary structure of the DNA-binding domain of the RT c-myb oncoprotein in solution. A multidimensional RT double and triple heteronuclear NMR study. RL Eur. J. Biochem. 216:147-154 (1993). RN [13] RA Myrset A. H., Bostad A., Jamin N., Lirsac P.-N., Toma F., Gabrielsen O. S. RT DNA and redox state induced conformational changes RT in the DNA-binding domain of the myb oncoprotein. RL EMBO J. 12:4625-4633 (1993). RN [14] RA Dini P. W., Lipsick J. S. RT Oncogenic truncation of the first repeat of c-myb RT decreases DNA binding in vitro and in vivo RL Mol. Cell. Biol. 13:7334-7348 (1993). RN [15] RA Ebneth A., Adermann K., Wolfes H. RT Does a synthetic peptide containing the leucine-zipper RT domain of c-myb form an alpha-helical structure in solution? RL FEBS Lett. 337:265-268 (1994). RN [16] RA Biedenkapp H., Borgmeyer U., Sippel A., Klempnauer K.-H. RT Viral myb oncogene encodes a sequence-specific DNA-binding activity RL Nature 335:835-837 (1988). RN [17] RA Luescher B., Eisenman R. N. RT New light on Myc and Myb. part II. Myb RL Genes Dev. 4:2235-2241 (1990). RN [18] RA Weston K., Bishop J. M. RT Transcriptional Activation by the v-myb oncogene and RT its cellular progenitor, c-myb RL Cell 58:85-93 (1989). RN [19] RA Graesser F. A., Graf T., Lipsick J. S. RT Protein truncation is required for the activation RT of the c-myb proto-oncogene RL Mol. Cell. Biol. 11:3987-3996 (1991). XX // AC T00140 XX ID T00140 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA c-Myc XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0012; bHLH-ZIP; 1.3.2.1.1. XX SZ 439 AA; 48.8 kDa (cDNA), 61, 64,67 kDa (SDS) XX SQ MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPP SQ LSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD SQ DETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQD SQ LSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVL SQ HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRC SQ HVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHN SQ VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLL SQ RKRREQLKHKLEQLRNSCA XX SC SwissProt #P01106 XX FT 1 143 3 independently trans-activating regions FT 46 55 Myc box I FT 58 58 phosphorylated Thr (MAPK, GSK3 [4]; FT 62 62 phosphorylated Ser (CKII, cdc2, MAPK [12], [5], [2]; FT 122 143 Myc box II, required for transforming activity [1], [3]; FT 251 263 acidic region FT 355 366 basic region FT 367 407 helix-loop-helix domain FT 413 434 leucine zipper (L4) XX SF isolated bHLH-ZIP region: mycPp XX FF proto-oncogene involved in cell proliferation control, may induce apoptosis; FF Ser-62 phosphorylation enhances trans-activating potential; FF negative autoregulation XX IN T00140; c-Myc; human, Homo sapiens. IN T00489; Max1; human, Homo sapiens. IN T00523; Myn; mouse, Mus musculus. IN T00722; Rb; human, Homo sapiens. IN T01003; SSRP1; human, Homo sapiens. IN T01566; deltaMax; human, Homo sapiens. IN T01567; Max2; human, Homo sapiens. XX MX M00118; V$MYCMAX_01 MX M00123; V$MYCMAX_02 XX BS R02092; AS$MYC_01; Quality: 2 BS R02094; AS$MYC_02; Quality: 1 BS R03222; AS$MYC_03; Quality: 6 BS R03223; AS$MYC_04; Quality: 6 BS R03224; AS$MYC_05; Quality: 6 BS R03225; AS$MYC_06; Quality: 6 BS R03226; AS$MYC_07; Quality: 6 BS R03227; AS$MYC_08; Quality: 6 BS R03228; AS$MYC_09; Quality: 6 BS R03229; AS$MYC_10; Quality: 6 BS R03230; AS$MYC_11; Quality: 6 BS R01916; HS$CMYC_07; Quality: 6; human, Homo sapiens BS R02893; HS$NEU_01; Quality: 6; human, Homo sapiens BS R04415; HS$ODC_01; Quality: 4; human, Homo sapiens BS R02207; MYC$CONS; Quality: 6 BS R04414; RAT$PTHYA_01; Quality: 1; rat, Rattus norvegicus XX DR EMBL: V00568; HSMYC1(r). DR EMBL: X00364; HSMYCC(g). DR EMBL: K02276; HSMYCDT(r). DR EMBL: X00196; HSMYCE12(g). DR SwissProt: P01106; MYC_HUMAN. DR PIR: A01349; TVHUM. DR PIR: A01350; TVHUT. XX RN [1] RA Penn L. J. Z., Brooks M. W., Laufer E. M., Littlewood RA T. D., Morgenstern J. P., Evan G. I., Lee W. M. F., Land H. RT Domains of human c-myc protein required for autosuppression RT and cooperation with ras oncogenes are overlapping RL Mol. Cell. Biol. 10:4961-4966 (1990). RN [2] RA Alvarez E., Northwood I. C. RT Pro-Leu-Ser/Thr-Pro is a consensus primary sequence RT for substrate protein phosphorylation RL J. Biol. Chem. 266:15277-15285 (1991). RN [3] RA Stone J., De Lange T., Ramsey G., Jakobovits E., Bishop RA J. M., Varmus H. E., Lee W. M. F. RT Definition of regions in human c-myc that are involved RT in transformation and nuclear translocation RL Mol. Cell. Biol. 7:1697-1709 (1987). RN [4] RA Henriksson M., Bakardjiev A., Klein G., Luescher B. RT Phosphorylation sites mapping in the N-terminal domain RT of c-myc modulate its transforming potential RL Oncogene 8:3199-3209 (1993). RN [5] RA Luescher B., Kuenzel E. A., Krebs E. G., Eisenman R. N. RT Myc oncoproteins are phosphorylated by casein kinase II RL EMBO J. 8:1111-1119 (1989). RN [6] RA Ariga H., Imamura Y., Iguchi-Ariga S. M. M. RT DNA replication origin and transcriptional enhancer RT in c-myc gene share the c-myc protein binding sequences RL EMBO J. 8:4273-4279 (1989). RN [7] RA Halazonetis T. D., Kandil A. N. RT Determination of the C-MYC DNA-binding site RL Proc. Natl. Acad. Sci. USA 88:6162-6166 (1991). RN [8] RA Blackwell T. K., Kretzner L., Blackwood E. M., Eisenman R. N., Weintraub H. RT Sequence-specific DNA binding by the c-Myc protein RL Science 250:1149-1151 (1990). RN [9] RA Dang C. V., Barrett J., Villa-Garcia M., Resar L. RA M. S., Kato G. J., Fearon E. R. RT Intracellular leucine zipper interactions suggest RT c-Myc hetero-oligomerization RL Mol. Cell. Biol. 11:954-962 (1991). RN [10] RA Blackwood E. M., Eisenman R. N. RT Max: a helix-loop-helix zipper protein that forms RT a sequence-specific DNA-binding complex with Myc RL Science 251:1211-1217 (1991). RN [11] RA Prendergast G. C., Lawe D., Ziff E. B. RT Association of Myn, the murine homolog of Max, with RT c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation RL Cell 65:395-407 (1991). RN [12] RA Seth A., Alvarez E., Gupta S., Davis R. J. RT A phosphorylation site located in the NH2-terminal RT domain of c-Myc increases transactivation of gene expression RL J. Biol. Chem. 266:23521-23524 (1991). RN [13] RA Dang C. V., McGuire M., Buckmire M., Lee W. M. F. RT Involvement of the 'leucine zipper' region in the RT oligomerization and transforming activity of human c-myc protein RL Nature 337:664-666 (1989). RN [14] RA Smith M. J., Charron-Prochownik D. C., Prochownik E. V. RT The leucine zipper of c-Myc is required for full inhibition RT of erythroleukemia differentiation RL Mol. Cell. Biol. 10:5333-5339 (1990). RN [15] RA Kato G. J., Barrett J., Villa-Garcia M., Dang C. V. RT An amino-terminal c-Myc domain required for neoplastic RT transformation activates transcription RL Mol. Cell. Biol. 10:5914-5920 (1990). RN [16] RA Prendergast G. C., Ziff E. B. RT Methylation-sensitive sequence-specific DNA binding RT by the c-Myc basic region RL Science 251:186-189 (1991). RN [17] RA Rustgi A. K., Dyson N., Bernards R. RT Amino-terminal domains of c-myc and N-myc proteins RT mediate binding to the retinoblastoma gene product RL Nature 352:541-544 (1991). XX // AC T00141 XX ID T00141 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA c-Myc XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0012; bHLH-ZIP; 1.3.2.1.1. XX SZ 416 AA; 46.0 kDa (cDNA), 59-62 kDa (SDS) [2]; XX SQ MPLSASLPSKNYDYDYDSVQPYFYFEEEEENFYLAAQQRGSELQPPAPSEDIWKKFELLP SQ TPPLSPSRRSSLAAASCFPSTADQLEMVTELLGGDMVNQSFICDPDDESFVKSIIIQDCM SQ WSGFSAAAKLEKVVSEKLATYQASRREGGPAAASRPGPPPSGPPPPPAGPAASAGLYLHD SQ LGAAAADCIDPSVVFPYPLSERAPRAAPPGANPAALLGVDTPPTTSSDSEEEQEEDEEID SQ VVTLAEANESESSTESSTEASEEHCKPHHSPLVLKRCHVNIHQHNYAAPPSTKVEYPAAK SQ RLKLDSGRVLKQISNNRKCSSPRTSDSEENDKRRTHNVLERQRRNELKLSFFALRDQIPE SQ VANNEKAPKVVILKKATEYVLSIQSDEHRLIAEKEQLRRRREQLKHKLEQLRNSRA XX SC SwissProt #P01109 XX FT 332 343 basic region FT 344 384 helix-loop-helix domain FT 390 411 leucine zipper (L4) FT 61 61 threonine-phosphorylation [3]; FT 65 65 serine-phosphorylation [3]; XX FF c-myc gene is involved in the development of B-cell lymphomas [5], [6]; FF phosphorylation may enhance trans-activation and may FF down-regulate transformation activity [3]; XX IN T00141; c-Myc; chick, Gallus gallus. IN T00489; Max1; human, Homo sapiens. IN T00523; Myn; mouse, Mus musculus. XX MX M00118; V$MYCMAX_01 MX M00123; V$MYCMAX_02 XX BS R02207; MYC$CONS; Quality: 6 XX DR EMBL: J00889; GGMYC(g). DR SwissProt: P01109; MYC_CHICK. DR PIR: FOCH; FOCH. XX RN [1] RA Eilers M., Schirm S., Bishop J. M. RT The MYC protein activates transcription of the a-prothymosin gene RL EMBO J. 10:133-141 (1991). RN [2] RA Hann S. R., Sloan-Brown K., Spotts G. D. RT Translational activation of the non-AUG-initiated RT c-myc 1 protein at high cell densities due to methionine deprivation RL Genes Dev. 6:1229-1240 (1992). RN [3] RA Henriksson M., Bakardjiev A., Klein G., Luescher B. RT Phosphorylation sites mapping in the N-terminal domain RT of c-myc modulate its transforming potential RL Oncogene 8:3199-3209 (1993). RN [4] RA Sheiness D. K., Hughes S. H., Varmus H. E., Stubblefield E., Bishop J. M. RT The Vertebrate Homology of the Putative Transforming RT Gene of Avian Myelocytomatosis Virus: Characteristics RT of the DNA Locus and Its RNA Transcript RL Virology 105:415-424 (1980). RN [5] RA Payne G. S., Courtneidge S. A., Crittenden L. B., RA Fadly A. M., Bishop J. M., Varmus H. E. RT Analysis of Avian Leukosis Virus DNA and RNA in Bursal RT Tumors: Viral Gene Expression Is Not Required for RT Maintenance of the Tumor State RL Cell 23:311-322 (1981). RN [6] RA Neel B. G., Hayward W. S., Robinson H. L., Fang J., Astrin S. M. RT Avian Leukosis Virus-Induced Tumors Have Common Proviral RT Integration Sites and Synthesize Discrete New RNAs: RT Oncogenesis by Promoter Insertion RL Cell 23:323-334 (1981). RN [7] RA Watson D. K., Reddy E. P., Duesberg P. H., Papas T. S. RT Nucleotide sequence analysis of the chicken c-myc RT gene reveals homologous and unique coding regions RT by comparison with the transforming gene of avian RT myelocytomatosis virus MC29, delta-gag-myc RL Proc. Natl. Acad. Sci. USA 80:2146-2150 (1983). RN [8] RA Ariga H., Imamura Y., Iguchi-Ariga S. M. M. RT DNA replication origin and transcriptional enhancer RT in c-myc gene share the c-myc protein binding sequences RL EMBO J. 8:4273-4279 (1989). RN [9] RA Blackwell T. K., Kretzner L., Blackwood E. M., Eisenman R. N., Weintraub H. RT Sequence-specific DNA binding by the c-Myc protein RL Science 250:1149-1151 (1990). RN [10] RA Dang C. V., Barrett J., Villa-Garcia M., Resar L. RA M. S., Kato G. J., Fearon E. R. RT Intracellular leucine zipper interactions suggest RT c-Myc hetero-oligomerization RL Mol. Cell. Biol. 11:954-962 (1991). RN [11] RA Blackwood E. M., Eisenman R. N. RT Max: a helix-loop-helix zipper protein that forms RT a sequence-specific DNA-binding complex with Myc RL Science 251:1211-1217 (1991). RN [12] RA Prendergast G. C., Lawe D., Ziff E. B. RT Association of Myn, the murine homolog of Max, with RT c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation RL Cell 65:395-407 (1991). XX // AC T00142 XX ID T00142 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA c-Myc XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0012; bHLH-ZIP; 1.3.2.1.1. XX SZ 439 AA; 48.9 kDa (cDNA), 64,67 kDa (SDS) XX SQ MPLNVSFANRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPP SQ LSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTELLGGDMVNQSFICDP SQ DDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQ SQ DLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSSSSDSLLSSESSPRATPEPLVL SQ HEETPPTTSSDSEEEQDDEEEIDVVSVEKRQPPAKRSESGSSPSRGHSKPPHSPLVLKRC SQ HVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSSPRSSDTEENDKRRTHN SQ VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQADEHKLISEKDLL SQ RKRREQLKHKLEQLRNSGA XX SC SwissProt #P09416 XX FT 251 263 acidic region (10/13) FT 355 366 basic region FT 367 407 helix-loop-helix domain FT 413 434 leucine zipper (L4) XX FF induces apoptosis in the absence of certain growth factors [3]; FF positively regulates the genes for translation initiation FF factors eIF-4E and -2alpha [1]; XX IN T00142; c-Myc; rat, Rattus norvegicus. IN T00489; Max1; human, Homo sapiens. IN T00523; Myn; mouse, Mus musculus. XX MX M00118; V$MYCMAX_01 MX M00123; V$MYCMAX_02 XX BS R02207; MYC$CONS; Quality: 6 XX DR EMBL: Y00396; RNCMYC(g). DR SwissProt: P09416; MYC_RAT. DR PIR: A26801; TVRTMC. XX RN [1] RA Rosenwald I. B., Rhoads D. B., Callanan L. D., Isselbacher RA K. J., Schmidt E. V. RT Increased expression of eukaryotic translation initiation RT factors eIF-4E and eIF-2a in response to growth induction by c-myc RL Proc. Natl. Acad. Sci. USA 90:6175-6178 (1993). RN [2] RA Hayashi K., Makino R., Kawamura H., Arisawa A., Yoneda K. RT Characterization of rat c-myc and adjacent region RL Nucleic Acids Res. 15:6419-6436 (1987). RN [3] RA Evan G. I., Wyllie A. H., Gilbert C. S., Littlewood RA T. D., Land H., Brooks M., Waters C. M., Penn L. Z., Hancock D. C. RT Induction of apoptosis in fibroblasts by c-myc protein RL Cell 69:119-128 (1992). RN [4] RA Ariga H., Imamura Y., Iguchi-Ariga S. M. M. RT DNA replication origin and transcriptional enhancer RT in c-myc gene share the c-myc protein binding sequences RL EMBO J. 8:4273-4279 (1989). XX // AC T00143 XX ID T00143 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA c-Myc XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0012; bHLH-ZIP; 1.3.2.1.1. XX SZ 439 AA; 49 kDa (cDNA), 64, 67 kDa (SDS) XX SQ MPLNVNFTNRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPP SQ LSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTELLGGDMVNQSFICDP SQ DDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQ SQ DLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSPSSDSLLSSESSPRASPEPLVL SQ HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQTPAKRSESGSSPSRGHSKPPHSPLVLKRC SQ HVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSSPRSSDTEENDKRRTHN SQ VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSIQADEHKLTSEKDLL SQ RKRREQLKHKLEQLRNSGA XX SC SwissProt #P01108 XX FT 251 263 acidic region (10/13) FT 355 366 basic region FT 367 407 helix-loop-helix domain FT 413 434 leucine zipper (L4) XX IN T00143; c-Myc; mouse, Mus musculus. IN T00489; Max1; human, Homo sapiens. IN T00523; Myn; mouse, Mus musculus. XX MX M00118; V$MYCMAX_01 MX M00123; V$MYCMAX_02 XX BS R02207; MYC$CONS; Quality: 6 XX DR EMBL: X01023; MMCMYC1(r). DR SwissProt: P01108; MYC_MOUSE. DR PIR: A93337; TVMS. DR Compel: C00135 XX RN [1] RA Ariga H., Imamura Y., Iguchi-Ariga S. M. M. RT DNA replication origin and transcriptional enhancer RT in c-myc gene share the c-myc protein binding sequences RL EMBO J. 8:4273-4279 (1989). RN [2] RA Blackwell T. K., Kretzner L., Blackwood E. M., Eisenman R. N., Weintraub H. RT Sequence-specific DNA binding by the c-Myc protein RL Science 250:1149-1151 (1990). RN [3] RA Dang C. V., Barrett J., Villa-Garcia M., Resar L. RA M. S., Kato G. J., Fearon E. R. RT Intracellular leucine zipper interactions suggest RT c-Myc hetero-oligomerization RL Mol. Cell. Biol. 11:954-962 (1991). RN [4] RA Blackwood E. M., Eisenman R. N. RT Max: a helix-loop-helix zipper protein that forms RT a sequence-specific DNA-binding complex with Myc RL Science 251:1211-1217 (1991). RN [5] RA Prendergast G. C., Lawe D., Ziff E. B. RT Association of Myn, the murine homolog of Max, with RT c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation RL Cell 65:395-407 (1991). XX // AC T00144 XX ID T00144 XX DT 15.10.92 (created); ewi. XX FA core-binding factor XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX BS R01657; FELV$FELV_02; Quality: 6; FeLV, feline leukemia virus XX RN [1] RA Fulton R., Plumb M., Shield L., Neil J. C. RT Structural Diversity and Nuclear Protein Binding Sites RT in the Long Terminal Repeats of Feline Leukemia Virus RL J. Virol. 64:1675-1682 (1990). XX // AC T00145 XX ID T00145 XX DT 15.10.92 (created); ewi. XX FA core-binding factor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01643; RADLV$RLV_02; Quality: 6; RadLV (BL/VL3 Kaplan radiation leukemia virus) BS R01647; RADLV$RLV_06; Quality: 6; RadLV (BL/VL3 Kaplan radiation leukemia virus) XX RN [1] RA Gorska-Flipot I., Jolicoeur P. RT DNA-Binding Proteins That Interact with the Long Terminal RT Repeat of Radiation Leukemia Virus RL J. Virol. 64:1566-1572 (1990). XX // AC T00146 XX ID T00146 XX DT 14.04.93 (created); ewi. XX FA CoS XX SY coactivator for SRF; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF coactivator for SRF XX RN [1] RA Seto E., Shi Y., Shenk T. RT YY1 is an initiator sequence-binding protein that RT directs and activates transcription in vitro RL Nature 354:241-245 (1991). XX // AC T00147 XX ID T00147 XX DT 26.01.93 (created); hse. XX FA COUP XX SY COUP-TF; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 2.1.2.10.5. XX SZ 45-50 kDa (SDS) XX FF member of the steroid hormone receptor superfamily XX IN T01345; RXR-alpha; human, Homo sapiens. XX MX M00158; V$COUP_01 XX BS R01812; RAT$POMC_02; Quality: 6; rat, Rattus norvegicus BS R03318; RAT$POMC_14; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Tsai S. Y., Sagami I., Wang H., Tsai M.-J., O'Malley B. W. RT Interaction between a DNA-Binding Transcription Factor RT (COUP) and a Non-DNA Binding Factor (S300-II) RL Cell 50:701-709 (1987). RN [2] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [3] RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA RT oncogene is in part due to a mutation in the DNA binding RT domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). XX // AC T00148 XX ID T00148 XX DT 15.10.92 (created); ewi. DT 26.01.93 (updated); hse. XX FA COUP XX SY COUP-TF; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL ; ; 2.1.2.10.5. XX SZ 43-48 kDa XX IN T01345; RXR-alpha; human, Homo sapiens. XX MX M00158; V$COUP_01 XX BS R00157; CHICK$APOVLDL_05; Quality: 3; chick, Gallus gallus BS R01193; CHICK$OA_02; Quality: 2; chick, Gallus gallus XX DR Compel: C00017 XX RN [1] RA Tsai S. Y., Sagami I., Wang H., Tsai M.-J., O'Malley B. W. RT Interaction between a DNA-Binding Transcription Factor RT (COUP) and a Non-DNA Binding Factor (S300-II) RL Cell 50:701-709 (1987). RN [2] RA Bagchi M. K., Tsai S. Y., Tsai M.-J., O'Malley B. W. RT Purification and Characterization of Chicken Ovalbumin RT Gene Upstream Promoter Transcription Factor from Homologous Oviduct Cells RL Mol. Cell. Biol. 7:4151-4158 (1987). RN [3] RA Wijnholds J., Philipsen J. N. J., Ab G. RT Tissue-specific and steroid-dependent interaction RT of transcription factors with the oestrogen-inducible RT apoVLDL II promoter in vivo RL EMBO J. 7:2757-2763 (1988). RN [4] RA Pastorcic M., Bagchi M. K., Tsai S. Y., Tsai M.-J., O'Malley B. W. RT Multiple protein binding sites within the ovalbumin RT gene 5'-flanking region: isolation and characterization RT of sequence-specific binding proteins RL Nucleic Acids Res. 17:6693-6711 (1989). RN [5] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [6] RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA RT oncogene is in part due to a mutation in the DNA binding RT domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). XX // AC T00149 XX ID T00149 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA COUP XX SY COUP-TF; COUP-alpha; ear3; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); 2.1.2.10.5. XX SZ 423 AA; 46.2 kDa (cDNA), 85-90 kDa; 43-53 kDa; 40-45 kDa (SDS) XX SQ MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA SQ PATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY SQ TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLN SQ GHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF SQ PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR SQ IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY SQ PNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSI SQ QCS XX SC SwissProt #P10589 XX CP (HeLa) XX FF represses RXR-mediated activation and retinoic acid responses; FF also antagonizes HNF-4-mediated activation [9]; XX IN T01331; RXR-alpha; mouse, Mus musculus. IN T01345; RXR-alpha; human, Homo sapiens. IN T01359; RXR-alpha; clawed frog, Xenopus laevis. XX MX M00158; V$COUP_01 XX BS R04224; AS$COUPA_01; Quality: 2 BS R03937; AS$RXR_01; Quality: 2 BS R03938; AS$RXR_02; Quality: 2 BS R01465; AS$TR_01; Quality: 2 BS R03940; AS$TR_05; Quality: 2 BS R01193; CHICK$OA_02; Quality: 2; chick, Gallus gallus BS R03405; HIV1$HIV1_20; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R03406; HIV1$HIV1_21; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R00135; HS$APOA1_01; Quality: 2; human, Homo sapiens BS R02657; HS$APOC3_01; Quality: 1; human, Homo sapiens BS R03932; RAT$CRBP1_01; Quality: 2; rat, Rattus norvegicus BS R03931; RAT$CRBP2_01; Quality: 6; rat, Rattus norvegicus BS R00911; RAT$INS1_07; Quality: 6; rat, Rattus norvegicus BS R00912; RAT$INS2_04; Quality: 6; rat, Rattus norvegicus XX DR EMBL: X16155; HSCOUPTF(r). DR EMBL: X12795; HSEAR3(g). DR SwissProt: P10589; COTF_HUMAN. DR PIR: S02710; S02710. DR Compel: C00016 DR Compel: C00018 DR Compel: C00124 DR Compel: C00125 XX RN [1] RA Cooney A. J., Tsai S. Y., O'Malley B. W., Tsai M.-J. RT Chicken ovalbumin upstream promoter transcription RT factor binds to a negative regulatory region in the RT human immunodeficiency virus type 1 long terminal repeat RL J. Virol. 65:2853-2860 (1991). RN [2] RA Hwung Y.-P., Wang L.-H., Tsai S. Y., Tsai M.-J. RT Differential Binding of the Chicken Ovalbumin Upstream RT Promoter (COUP) Transcription Factor to Two Different Promoters RL J. Biol. Chem. 263:13470-13474 (1988). RN [3] RA Sagami I., Tsai S. Y., Wang H., Tsai M.-J., O'Malley B. W. RT Identification of Two Factors Required for Transcription RT of the Ovalbumin Gene RL Mol. Cell. Biol. 6:4259-4267 (1986). RN [4] RA Pastorcic M., Wang H., Elbrecht A., Tsai S. Y., Tsai M.-J., O'Malley B. W. RT Control of transcription initiation in vitro requires RT binding of a transcription factor to the distal promoter RT of the ovalbumin gene RL Mol. Cell. Biol. 6:2784-2791 (1986). RN [5] RA Tsai S. Y., Sagami I., Wang H., Tsai M.-J., O'Malley B. W. RT Interaction between a DNA-Binding Transcription Factor RT (COUP) and a Non-DNA Binding Factor (S300-II) RL Cell 50:701-709 (1987). RN [6] RA Kliewer S. A., Umesono K., Heyman R. A., Mangelsdorf RA D. J., Dyck J. A., Evans R. M. RT Retinoid X receptor COUP-TF interactions modulate retinoic acid signaling RL Proc. Natl. Acad. Sci. USA 89:1448-1452 (1992). RN [7] RA Tran P., Zhang X.-K., Salbert G., Hermann T., Lehmann J. M., Pfahl M. RT COUP orphan receptors are negative regulators of retinoic RT acid response pathways RL Mol. Cell. Biol. 12:4666-4676 (1992). RN [8] RA Wang L.-H., Tsai S. Y., Sagami I., Tsai M.-J., O'Malley B. W. RT Purification and Characterization of Chicken Ovalbumin RT Upstream Promoter Transcription Factor from HeLa Cells RL J. Biol. Chem. 262:16080-16086 (1987). RN [9] RA Mietus-Snyder M., Sladek F. M., Ginsburg G. S., Kuo RA C. F., Ladias J. A. A., Darnell Jr. J. E., Karathanasis S. K. RT Antagonism between apolipoprotein AI regulatory protein RT 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates RT apolipoprotein CIII gene expression in liver and intestinal cells RL Mol. Cell. Biol. 12:1708-1718 (1992). RN [10] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [11] RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA RT oncogene is in part due to a mutation in the DNA binding RT domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). XX // AC T00150 XX ID T00150 XX DT 15.10.92 (created); ewi. DT 28.03.95 (updated); hiwi. XX FA CP1 XX SY CBF; NF-Y; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 140-150 kDa XX MX M00209; V$NFY_C XX BS R03477; HS$CYBH_01; Quality: 6; human, Homo sapiens BS R03038; HS$DPOLA_03; Quality: 6; human, Homo sapiens BS R03119; HS$EG_07; Quality: 6; human, Homo sapiens BS R00564; HS$GG_18; Quality: 6; human, Homo sapiens BS R01858; HS$GG_19; Quality: 6; human, Homo sapiens BS R01859; HS$GG_20; Quality: 6; human, Homo sapiens BS R02888; HS$GG_33; Quality: 6; human, Homo sapiens BS R04200; HS$GG_41; Quality: 4; human, Homo sapiens BS R00766; HS$HSP70_07; Quality: 6; human, Homo sapiens BS R00768; HS$HSP70_09; Quality: 6; human, Homo sapiens BS R01443; HSV1$TK_02; Quality: 6; HSV-1, herpes simplex virus type 1 BS R03043; MOUSE$THY1_03; Quality: 6; mouse, Mus musculus XX RN [1] RA Wright K. L., Vilen B. J., Itoh-Lindstrom Y., Moore RA T. L., Li G., Criscitiello M., Cogswell P., Clarke J. B., Ting J. P. Y. RT CCAAT box binding protein NF-Y facilitates in vivo RT recruitment of upstream DNA binding transcription factors RL EMBO J. 13:4042-4053 (1994). RN [2] RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S. RT The deletion of the distal CCAAT box region of the RT Agamma-globin gene in black HPFH abolishes the binding RT of the erythroid specific protein NFE3 and of the CCAAT displacement protein RL Nucleic Acids Res. 17:6681-6691 (1989). RN [3] RA Taylor I. C. A., Kingston R. E. RT Factor Substitution in a Human HSP70 Gene Promoter: RT TATA-Dependent and TATA-Independent Interactions RL Mol. Cell. Biol. 10:165-175 (1990). RN [4] RA Ben-Hattar J., Beard P., Jiricny J. RT Cytosine methylation in CTF and Sp1 recognition sites RT of an HSV tk promoter: effects on transcription in RT vivo and on factor binding in vitro RL Nucleic Acids Res. 17:10179-10190 (1989). RN [5] RA Chodosh L. A., Baldwin A. S., Carthew R. W., Sharp P. A. RT Human CCAAT-Binding Proteins Have Heterologous Subunits RL Cell 53:11-24 (1988). RN [6] RA Chodosh L. A., Olesen J., Hahn S., Baldwin A. S., Guarente L., Sharp P. A. RT A Yeast and a Human CCAAT-Binding Protein Have Heterologous RT Subunits That Are Functionally Interchangeable RL Cell 53:25-35 (1988). RN [7] RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M. RT The -117 mutation in Greek HPFH affects the binding RT of three nuclear factors to the CCAAT region of the gamma-globin gene RL EMBO J. 7:3099-3107 (1988). RN [8] RA Spanopoulou E., Giguere V., Grosveld F. RT The functional domains of the murine Thy-1 gene promoter RL Mol. Cell. Biol. 11:2216-2228 (1991). RN [9] RA Fucharoen S., Shimizu K., Fukumaki Y. RT A novel C-T transition within the distal CCAAT motif RT of the Ggamma-globin gene in the Japanese HPFH: implication RT of factor binding in elevated fetal globin expression RL Nucleic Acids Res. 18:5245 (1990). XX // AC T00151 XX ID T00151 XX DT 15.10.92 (created); ewi. DT 27.08.96 (updated); ewi. XX FA CP2 XX SY CP-2; LBP-1c; alpha-CP2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 1.7.1.0.1. XX SZ 501 AA; 57.2 kDa (cDNA), 64-66 kDa (SDS) XX SQ MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDN SQ ENKILPFQYVLCAATSPAVKLHDETLTYLNQAQSYEIRMLDNRKLGELPEINGKLVKSIF SQ RVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPA SQ KRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKENENGEYTEHLHSASCQIKVFKP SQ KGADRKQKMDREKMEKRTPHEKEKYQPSYETTILTECSPWPEITYVNNSPSPGFNSSHSS SQ FSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFSGADLLKL SQ TRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQESLQLREQQQQQQQQQQKHEDGDS SQ NGTFFVYHAIYLEELTAVELTEKIAQLFSISPCQISQIYKQGPTGIHVLISDEMIQNFQE SQ EACFILDTMKETNDSYHIILK XX SC translated from edited EMBL entry #M84810 XX FT 63 270 distantly related to Elf-1 FT 39 292 DNA-binding domain FT 236 248 basic region FT 258 398 serine-/threonine-/proline-rich region (S-T-P domain) FT 381 501 dimerisation domain FT 404 413 glutamine-rich region XX SF glutamine-rich region XX FF related to Elf-1 (Drosophila) XX BS R04132; HS$EG_10; Quality: 4; human, Homo sapiens BS R00571; HS$ZG_07; Quality: 6; human, Homo sapiens XX DR EMBL: U01965; HS01965(g). DR EMBL: M84810; HSAGTFCP(r). DR EMBL: M76988; HSAGTFCPB(r). XX RN [1] RA Dutta A., Stoeckle M. Y., Hanafusa H. RT Serum and v-src increase the level of a CCAAT-binding RT factor required for transcription from a retroviral long terminal repeat RL Genes Dev. 4:243-254 (1990). RN [2] RA Kim C. G., Swendeman S. L., Barnhart K. M., Sheffery M. RT Promoter elements and erythroid cell nuclear factors RT that regulate alpha-globin gene transcription in vitro RL Mol. Cell. Biol. 10:5958-5966 (1990). RN [3] RA Jane S. M., Nienhuis A. W., Cunningham J. M. RT Hemoglobin switching in man and chicken is mediated RT by a heteromeric complex between the ubiquitous transcription RT factor CP2 and a developmentally specific protein RL EMBO J. 14:97-105 (1995). RN [4] RA Chodosh L. A., Baldwin A. S., Carthew R. W., Sharp P. A. RT Human CCAAT-Binding Proteins Have Heterologous Subunits RL Cell 53:11-24 (1988). RN [5] RA Chodosh L. A., Olesen J., Hahn S., Baldwin A. S., Guarente L., Sharp P. A. RT A Yeast and a Human CCAAT-Binding Protein Have Heterologous RT Subunits That Are Functionally Interchangeable RL Cell 53:25-35 (1988). RN [6] RA Lim L. C., Swendeman S. L., Sheffery M. RT Molecular cloning of the alpha-globin transcription factor CP2 RL Mol. Cell. Biol. 12:828-835 (1992). RN [7] RA Hooft van Huijsduijnen R., Li X. Y., Black D., Matthes RA H., Benoist C., Mathis D. RT Co-evolution from yeast to mouse: cDNA cloning of RT the two NF-Y (CP-1/CBF) subunits RL EMBO J. 9:3119-3127 (1990). XX // AC T00152 XX ID T00152 XX DT 26.01.93 (created); ewi. DT 30.08.96 (updated); ewi. XX FA CP2 XX SY CP-2; LBP-1c; alpha-CP2; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 1.7.1.0.1. XX SZ 502 AA; 57.0 kDa (cDNA); 64-66 kDa (SDS) XX SQ MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDN SQ ENEILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPELNGKLVKSIF SQ RVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGVIDPRANPTQLNTVEFLWDPS SQ KRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKENGNGEYTEHLHSASCQIKVFKP SQ KGADRKQKIDREKMEKRTPHEKEKYQPSYETTILTECSPWPEITYVNNSPSPGFNSSHSS SQ FSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFSGADLLKL SQ TRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQESLQLREQQPQPQPQPQKQEDGDS SQ NGTFFVYHAIYLEELTAVELTEKIAQLFSISPHQISQIYKQGPTGIHVVISDEMVQNFQE SQ EACFILDTMEAETSDSYHVILK XX SC translated from EMBL #M84809 XX FT 63 270 distantly related to Elf-1 FT 39 292 DNA-binding domain FT 236 248 basic region FT 258 398 serine-/threonine-/proline-rich region (S-T-P domain) FT 381 501 dimerisation domain FT 404 413 glutamine-rich region XX SF glutamine-rich region, phosphorylation XX FF related to Elf-1 (Drosophila); FF appears to be functionally limiting in nuclear B cell extracts XX MX M00072; V$CP2_01 XX BS R02866; AS$CP2_01; Quality: 6 BS R04171; CP2$CONS_02; Quality: 2 BS R04132; HS$EG_10; Quality: 2; human, Homo sapiens BS R04167; MOUSE$AAG_07; Quality: 2; mouse, Mus musculus BS R04168; MOUSE$AAG_08; Quality: 2; mouse, Mus musculus BS R04169; MOUSE$AAG_09; Quality: 2; mouse, Mus musculus BS R04170; MOUSE$AAG_10; Quality: 2; mouse, Mus musculus BS R00090; MOUSE$ALBU_09; Quality: 6; mouse, Mus musculus BS R01799; RAT$ALDB_02; Quality: 6; rat, Rattus norvegicus BS R00444; RAT$GF_04; Quality: 6; rat, Rattus norvegicus XX DR EMBL: M84809; MMAGTFCP(r). XX RN [1] RA Kim C. G., Swendeman S. L., Barnhart K. M., Sheffery M. RT Promoter elements and erythroid cell nuclear factors RT that regulate alpha-globin gene transcription in vitro RL Mol. Cell. Biol. 10:5958-5966 (1990). RN [2] RA Lim L. C., Fang L., Swendeman S. L., Sheffery M. RT Characterization of the molecularly cloned murine RT alpha-globin transcription factor CP2 RL J. Biol. Chem. 268:18008-18017 (1992). RN [3] RA Lim L. C., Swendeman S. L., Sheffery M. RT Molecular cloning of the alpha-globin transcription factor CP2 RL Mol. Cell. Biol. 12:828-835 (1992). XX // AC T00153 XX ID T00153 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA alpha-CP1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 27-38 kDa (SDS), 101 kDa (sedim.) XX SF heterotrimer SF at least seven polypeptides of three groups observed: SF alpha (35 kDa), beta (28, 27 kDa), gamma (33, 34, 37, 38 kDa) SF stable alphabeta association, weak association of gamma XX BS R02874; AS$ACP1_01; Quality: 6 BS R02875; AS$ACP1_02; Quality: 6 BS R02876; AS$ACP1_03; Quality: 6 BS R02877; AS$ACP1_04; Quality: 6 BS R02878; AS$ACP1_05; Quality: 6 BS R02879; AS$ACP1_06; Quality: 6 BS R02880; AS$ACP1_07; Quality: 6 BS R02881; AS$ACP1_08; Quality: 6 BS R00510; MOUSE$AAG_04; Quality: 6; mouse, Mus musculus BS R00511; MOUSE$AAG_05; Quality: 6; mouse, Mus musculus XX RN [1] RA Kim C. G., Barnhart K. M., Sheffery M. RT Purification of Multiple Erythroid Cell Proteins That RT Bind the Promoter of the alpha-Globin Gene RL Mol. Cell. Biol. 8:4270-4281 (1988). RN [2] RA Barnhart K. M., Kim C. G., Banerji S. S., Sheffery M. RT Identification and Characterization of Multiple Erythroid RT Cell Proteins That Interact with the Promoter of the RT Murine alpha-Globin Gene RL Mol. Cell. Biol. 8:3215-3226 (1988). RN [3] RA Kim C. G., Sheffery M. RT Physical characterization of the purified CCAAT transcription RT factor, alpha-CP1 RL J. Biol. Chem. 265:13362-13369 (1990). XX // AC T00154 XX ID T00154 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CP1A XX SY CBF-A (rat); CP1-A; HAP3 (yeast); NF-YB (mouse); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 1.6.1.0.1. XX SZ 207 AA; 40 kDa (SDS), 34 kDa (cDNA) XX SQ MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLP SQ IANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILF SQ AMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLIT SQ TDGQQQNVMVYTTSYQQISGVQQIQFS XX SC SwissProt #P25208 XX CP (HeLa) XX IN T00088; CBF-B; rat, Rattus norvegicus. IN T00349; HAP2; yeast, Saccharomyces cerevisiae. IN T00351; HAP4; yeast, Saccharomyces cerevisiae. IN T00615; NF-YA; mouse, Mus musculus. XX MX M00209; V$NFY_C XX BS R00988; AD$MLP_03; Quality: 6; adenovirus BS R00989; AD$MLP_04; Quality: 6; adenovirus BS R00263; Y$CYC1_10; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: X59710; HSNFYB(empty). DR SwissProt: P25208; CBFA_HUMAN. XX RN [1] RA Dorn A., Bollekens J., Staub A., Benoist C., Mathis D. RT A Multiplicity of CCAAT Box-Binding Proteins RL Cell 50:863-872 (1987). RN [2] RA Dutta A., Stoeckle M. Y., Hanafusa H. RT Serum and v-src increase the level of a CCAAT-binding RT factor required for transcription from a retroviral long terminal repeat RL Genes Dev. 4:243-254 (1990). RN [3] RA Chodosh L. A., Baldwin A. S., Carthew R. W., Sharp P. A. RT Human CCAAT-Binding Proteins Have Heterologous Subunits RL Cell 53:11-24 (1988). RN [4] RA Chodosh L. A., Olesen J., Hahn S., Baldwin A. S., Guarente L., Sharp P. A. RT A Yeast and a Human CCAAT-Binding Protein Have Heterologous RT Subunits That Are Functionally Interchangeable RL Cell 53:25-35 (1988). RN [5] RA Hooft van Huijsduijnen R., Li X. Y., Black D., Matthes RA H., Benoist C., Mathis D. RT Co-evolution from yeast to mouse: cDNA cloning of RT the two NF-Y (CP-1/CBF) subunits RL EMBO J. 9:3119-3127 (1990). XX // AC T00155 XX ID T00155 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA alpha-CP2a XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX RN [1] RA Barnhart K. M., Kim C. G., Banerji S. S., Sheffery M. RT Identification and Characterization of Multiple Erythroid RT Cell Proteins That Interact with the Promoter of the RT Murine alpha-Globin Gene RL Mol. Cell. Biol. 8:3215-3226 (1988). XX // AC T00156 XX ID T00156 XX DT 15.10.92 (created); ewi. XX FA alpha-CP2a, alpha-CP2b XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 64+66 kDa XX BS R00509; MOUSE$AAG_03; Quality: 6; mouse, Mus musculus BS R00510; MOUSE$AAG_04; Quality: 6; mouse, Mus musculus XX RN [1] RA Kim C. G., Barnhart K. M., Sheffery M. RT Purification of Multiple Erythroid Cell Proteins That RT Bind the Promoter of the alpha-Globin Gene RL Mol. Cell. Biol. 8:4270-4281 (1988). XX // AC T00157 XX ID T00157 XX DT 15.10.92 (created); ewi. DT 22.08.96 (updated); ewi. XX FA CP1B XX SY CBF-B (rat); CP1-B; HAP2 (yeast); NF-YA (mouse); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 1.6.1.0.2. XX SZ 347 AA; 36.9 kDa (cDNA), 32 kDa (SDS) XX SQ MEQYTANSNSSTEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPL SQ MVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAV SQ QVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTIL SQ QQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMV SQ PGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLH SQ ESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS XX SC SwissProt #P23511 XX CP (HeLa) XX IN T00087; CBF-A; rat, Rattus norvegicus. IN T00350; HAP3; yeast, Saccharomyces cerevisiae. IN T00351; HAP4; yeast, Saccharomyces cerevisiae. IN T00616; NF-YB; mouse, Mus musculus. IN T01263; HAP3; fission yeast, Schizosaccharomyces pombe. XX MX M00209; V$NFY_C XX BS R00988; AD$MLP_03; Quality: 6; adenovirus BS R00990; AD$MLP_05; Quality: 6; adenovirus BS R00264; Y$CYC1_11; Quality: 2; yeast, Saccharomyces cerevisiae XX DR SwissProt: P23511; CBFB_HUMAN. DR PIR: A39123; A39123. DR PIR: S22816; S22816. XX RN [1] RA Dorn A., Bollekens J., Staub A., Benoist C., Mathis D. RT A Multiplicity of CCAAT Box-Binding Proteins RL Cell 50:863-872 (1987). RN [2] RA Dutta A., Stoeckle M. Y., Hanafusa H. RT Serum and v-src increase the level of a CCAAT-binding RT factor required for transcription from a retroviral long terminal repeat RL Genes Dev. 4:243-254 (1990). RN [3] RA Chodosh L. A., Baldwin A. S., Carthew R. W., Sharp P. A. RT Human CCAAT-Binding Proteins Have Heterologous Subunits RL Cell 53:11-24 (1988). RN [4] RA Chodosh L. A., Olesen J., Hahn S., Baldwin A. S., Guarente L., Sharp P. A. RT A Yeast and a Human CCAAT-Binding Protein Have Heterologous RT Subunits That Are Functionally Interchangeable RL Cell 53:25-35 (1988). RN [5] RA Hooft van Huijsduijnen R., Li X. Y., Black D., Matthes RA H., Benoist C., Mathis D. RT Co-evolution from yeast to mouse: cDNA cloning of RT the two NF-Y (CP-1/CBF) subunits RL EMBO J. 9:3119-3127 (1990). XX // AC T00158 XX ID T00158 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA alpha-CP2b XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX RN [1] RA Barnhart K. M., Kim C. G., Banerji S. S., Sheffery M. RT Identification and Characterization of Multiple Erythroid RT Cell Proteins That Interact with the Promoter of the RT Murine alpha-Globin Gene RL Mol. Cell. Biol. 8:3215-3226 (1988). XX // AC T00159 XX ID T00159 XX DT 15.10.92 (created); ewi. XX FA CPBP XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00641; HBV$HBVE_12; Quality: 6; HBV, human hepatitis B virus XX RN [1] RA Karpen S., Banerjee R., Zelent A., Price P., Acs G. RT Identification of protein-binding sites in the hepatitis RT B virus enhancer and core promoter domains RL Mol. Cell. Biol. 8:5159-5165 (1988). XX // AC T00160 XX ID T00160 XX DT 12.03.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CPC1 XX OS Neurospora crassa OC eukaryota; plantae; thallobionta; eumycota; ascomycotina; OC pyrenomycetes; sordariales; sordariaceae XX HO GCN4 XX CL C0008; bZIP; 1.1.1.5.2. XX SZ 269 AA XX SQ MFSELDLLDFATFDGGATTEAAFASPANQTYDLSSSVPSSVSNMGTVSPQELLLHEPYLS SQ APSSTALTALTSPSLFDGSPDFDTFDISPNFGHSDLENPDTWFSLFPDATPLPQAQAQVQ SQ TQPQTQTQTEQQTQPLPELVQSVQPTVQPTVEQTVHSVEASPATPSEDLEVLSPGSGHQR SQ RKSSVSPPSGRHSSVAGVGSRRRDKLYPYHVEDPSDVVAMKRARNTLAARKSRERKAQRL SQ EELEAKIEELIAERDRWKNLALAHGASTE XX SC SwissProt #P11115 XX FT 221 239 basic region XX SF putative bZIP factor SF L2WH SF glutamine-/threonine-/proline-rich region XX BS R02976; NEUCR$CPC1_01; Quality: 6; Neurospora crassa BS R02978; NEUCR$TRP3_01; Quality: 6; Neurospora crassa BS R02979; NEUCR$TRP3_02; Quality: 6; Neurospora crassa XX DR EMBL: J03262; NCCPC(g). DR SwissProt: P11115; CPC1_NEUCR. DR PIR: A30208; A30208. XX RN [1] RA Ebbole D. J., Paluh J. L., Plamann M., Sachs M. S., Yanofsky C. RT cpc1, the general regulatory gene for genes of amino RT acid biosynthesis in Neurospora crassa, is differentially RT expressed during asexual life cycle RL Mol. Cell. Biol. 11:928-934 (1991). RN [2] RA Paluh J. L., Yanofsky C. RT Characterization of Neurospora CPC1, a bZIP DNA-binding RT protein that does not require aligned heptad leucines for dimerization RL Mol. Cell. Biol. 11:935-944 (1991). XX // AC T00161 XX ID T00161 XX DT 25.01.93 (created); ewi. XX FA CPE binding protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 110 kDa XX FF activator; FF binds to the cap proximal element XX RN [1] RA Boyer T. G., Maquat L. E. RT Minimal sequence and factor requirements for the initiation RT of transcription from an atypical, TATATAA box-containing RT housekeeping promoter RL J. Biol. Chem. 265:20524-20532 (1990). XX // AC T00162 XX ID T00162 XX DT 28.10.92 (created); ewi. DT 22.08.96 (updated); ewi. XX FA CreA XX OS Aspergillus nidulans (Emericella nidulans) OC eukaryota; plantae; thallobionta; eumycota; ascomycotina; OC plectomycetes; eurotiales; trichocomaceae XX CL C0001; CH; 2.3.3.0.4. XX SZ 416 AA; 44.7 kDa (gene) XX SQ MPQPGSSVDFSNLLNPQNNTAIPAEVSNATASATMASGASLLPPMVKGARPAAEEARQDL SQ PRPYKCPLCERAFHRLEHQTRHIRTHTGEKPHACQFPGCSKRFSRSDELTRHSRIHNNPN SQ SRRGNKAQHLAAAAAAAAANQDGSAMANNAGSMMPPPSKPITRSAPVSQVGSPDISPPHS SQ FSNYANHMRSNLSPYSRTSERASSGMDINLLATAASQVERDESFGFRSGQRSHHMYGPRH SQ GSRGLPSLSAYAISHSMSRSHSHEDEDSYASHRVKRSRPNSPNSTAPSSPTFSHDSLSPT SQ PDHTPLATPAHSPRLKPLSPSELHLPSIRHLSLHHTPALAPMEPQAEGPNYYNPNQPHVG SQ PSISDIMSRPEGAQRKLPIPQVPKVAVQDMLNPSGFTSVSSSTANSVAGGDLAERF XX SC SwissProt #Q01981 XX FT 131 139 alanine-rich region (9/9) FT 66 86 zinc finger motif 1 FT 94 116 zinc finger motif 2 XX FF regulator of carbon catabolite repression XX DR EMBL: L03811; ANCREA(g). DR EMBL: L03563; ENCREA(g). DR SwissProt: Q01981; CREA_EMENI. XX RN [1] RA Dowzer C. E. A., Kelly A. M. RT Analysis of the creA Gene, a regulator of carbon catabolite RT repression in Aspergillus nidulans RL Mol. Cell. Biol. 11:5701-5709 (1991). XX // AC T00163 XX ID T00163 XX DT 15.10.92 (created); ewi. DT 23.06.97 (updated); ewi. XX FA CREB XX SY ATF-47; CREB-341; CREB-B; CREBalpha; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO ATF, 47-kDa protein, EIIA-EF, EPF, EIIaE-B XX CL C0008; bZIP; 1.1.2.0.1.1. XX SZ 341 AA; 36.7 kDa (cDNA) XX SQ MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN SQ GQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTD SQ SQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG SQ QYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQV SQ VVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAAREC SQ RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD XX SC SwissProt #P16220 XX FT 156 156 serine, potential CKII phosphorylation site FT 282 284 AAR, critical for interaction with tax [7]; FT 10 87 glutamine-rich region Q1 (17/78) FT 88 101 alpha domain FT 101 160 kinase-inducible modulating domain (KID) FT 133 133 Ser-phosphorylation by PKA FT 176 253 Gln-rich region Q2, activation domain (16/77) FT 284 309 basic region FT 311 332 zipper (L4) XX SF multiple splice variants [18]; SF leucine zipper-independent binding of the coactivator CBP [3]; SF the Tax activator of HTLV-I interacts with the basic SF region [23], [24] decreasing the dissociation constant SF for CREB homodimers (from 7 nM to 0.1 nM) and for SF (CREB)2-DNA complexes (from 60 nM to 14.4 nM) [20] SF and altering the DNA binding selectivity [23]; SF the activity of Q2 is mediated by direct interaction SF with the TAF-110 component of TFIID [8]; XX CP spleen, heart, thymus, gut, brain, kidney; very weak CP expression in testis and liver XX FF activator; FF mediates cAMP-response after phosphorylation at Ser-133 FF by PKA within the kinase-inducible domain (KID) [16]; FF KID cooperates with Q2 domain in transcriptional stimulation; FF Q2 interacts with the TAF-110 component of TFIID [8]; FF dephosphorylation may be by nuclear protein phosphatase 2A (PP2A) [2]; FF significant enhancement of dimerization by Tax [4], [15]; FF may also inhibit activity of some unrelated factors [6]; FF altered DNA-binding specificity after complexing with pX [9]; XX IN T00051; ATF; human, Homo sapiens. IN T00163; CREB; human, Homo sapiens. IN T00165; deltaCREB; rat, Rattus norvegicus. IN T00166; deltaCREB; human, Homo sapiens. IN T00793; Tax; HTLV-I, human T-cell lymphotropic virus type I. IN T00968; ATF-1; human, Homo sapiens. IN T01304; ATF-1; mouse, Mus musculus. IN T01305; CBP100; mouse, Mus musculus. IN T01311; deltaCREB; mouse, Mus musculus. IN T01314; CREMalpha; mouse, Mus musculus. IN T01318; CBP; mouse, Mus musculus. IN T01319; ICER; rat, Rattus norvegicus. IN T01381; deltaCREB; mink, Mustela vison. IN T01384; pX; EBV, Epstein-Barr virus. XX MX M00039; V$CREB_01 MX M00113; V$CREB_02 MX M00114; V$TAXCREB_01 MX M00115; V$TAXCREB_02 XX BS R00309; AD$E1A_03; Quality: 2; adenovirus type 5 BS R00322; AD$E2AE1_07; Quality: 2; adenovirus type 2 BS R00343; AD$E3_05; Quality: 1; adenovirus type 2 BS R00356; AD$E4_10; Quality: 2; adenovirus type 5 BS R00362; AD$E4_16; Quality: 6; adenovirus type 5 BS R00366; AD$E4_20; Quality: 2; adenovirus type 5 BS R04240; AS$TAXCREB_01; Quality: 2 BS R04241; AS$TAXCREB_02; Quality: 2 BS R04242; AS$TAXCREB_03; Quality: 2 BS R04110; CREB$CONS_01; Quality: 2 BS R04045; HBV$HBVE_27; Quality: 2; HBV, human hepatitis B virus BS R02906; HS$B2AR_01; Quality: 2; human, Homo sapiens BS R00471; HS$CFOS_14; Quality: 2; human, Homo sapiens BS R04356; HS$CYCA_02; Quality: 6; human, Homo sapiens BS R00454; HS$FN_01; Quality: 2; human, Homo sapiens BS R00455; HS$FN_02; Quality: 2; human, Homo sapiens BS R00456; HS$FN_03; Quality: 4; human, Homo sapiens BS R00592; HS$GHA_02; Quality: 4; human, Homo sapiens BS R02710; HS$INS_04; Quality: 4; human, Homo sapiens BS R03738; HS$PTH_01; Quality: 6; human, Homo sapiens BS R01508; HS$U4CSN_01; Quality: 6; human, Homo sapiens BS R01559; HS$VIP_01; Quality: 2; human, Homo sapiens BS R00777; HT1$HTLV1_01; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R00779; HT1$HTLV1_03; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R00780; HT1$HTLV1_04; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R00479; MOUSE$CFOS_08; Quality: 6; mouse, Mus musculus BS R01053; MOUSE$M1H2KB_01; Quality: 6; mouse, Mus musculus BS R01062; MOUSE$M1H2KB_10; Quality: 6; mouse, Mus musculus BS R02378; RAT$CCK_01; Quality: 1; rat, Rattus norvegicus BS R01215; RAT$PEPCK_04; Quality: 2; rat, Rattus norvegicus BS R01358; RAT$SSTA_01; Quality: 2; rat, Rattus norvegicus XX DR EMBL: M27691; HSCREB(r). DR EMBL: M34356; HSCREB01(r). DR EMBL: X68994; HSCREBGNA(g). DR SwissProt: P16220; CREB_HUMAN. DR PIR: A35769; A35769. DR PIR: B35769; B35769. DR PIR: B37340; B37340. DR PIR: S12561; S12561. DR Compel: C00088 XX RN [1] RA Quinn P. G. RT Distinct activation domains within cAMP response element-binding RT protein (CREB) mediate basal and cAMP-stimulated transcription RL J. Biol. Chem. 268:16999-17009 (1993). RN [2] RA Wadzinski B. E., Wheat W. H., Jaspers S., Peruski RA Jr. L. F., Lickteig R. L., Johnson G. L., Klemm D. J. RT Nuclear protein phosphatase 2A dephosphorylates protein RT kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation RL Mol. Cell. Biol. 13:2822-2834 (1993). RN [3] RA Chrivia J. C., Kwok R. P. S., Lamb N., Hagiwara M., RA Montminy M. R., Goodman R. H. RT Phosphorylated CREB binds specifically to the nuclear protein CBP RL Nature 365:855-859 (1993). RN [4] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [5] RA Stehle J. H., Foulkes N. S., Molina C. A., Simonneaux RA V., Pevet P., Sassone-Corsi P. RT Adrenergic signals direct rhythmic expression of transcriptional RT repressor CREM in the pineal gland RL Nature 365:314-320 (1993). RN [6] RA Lemaigre F. P., Ace C. I., Green M. R. RT The cAMP response element binding protein, CREB, is RT a potent inhibitor of diverse transcriptional activators RL Nucleic Acids Res. 21:2907-2911 (1993). RN [7] RA Adya N., Zhao L.-J., Huang W., Boros I., Giam C.-Z. RT Expansion of CREB's DNA recognition specificity by RT Tax results from interaction with Ala-Ala-Arg at positions RT 282-284 near the conserved DNA-binding domain of CREB RL Proc. Natl. Acad. Sci. USA 91:5642-5646 (1994). RN [8] RA Ferreri K., Gill G., Montminy M. RT The cAMP-regulated transcription factor CREB interacts RT with a component of the TFIID complex RL Proc. Natl. Acad. Sci. USA 91:1210-1213 (1994). RN [9] RA Maguire H. F., Hoeffler J. P., Siddiqui A. RT HBV X protein alters the DNA binding specificity of RT CREB and ATF-2 by protein-protein interactions RL Science 252:842-844 (1991). RN [10] RA Weller P., Bark C., Janson L., Pettersson U. RT Transcription analysis of a human U4C gene: involvement RT of transcription factors novel to snRNA gene expression RL Genes Dev. 2:1389-1399 (1988). RN [11] RA Fink J. S., Verhave M., Kasper S., Tsukada T., Mandel G., Goodman R. H. RT The CGTCA sequence motif is essential for biological RT activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer RL Proc. Natl. Acad. Sci. USA 85:6662-6666 (1988). RN [12] RA Hardy S., Shenk T. RT Adenoviral control regions activated by E1A and the RT cAMP responsive element bind to the same factor RL Proc. Natl. Acad. Sci. USA 85:4171-4175 (1988). RN [13] RA Garcia J., Wu F., Gaynor R. RT Upstream regulatory regions required to stabilize RT binding to the TATA sequence in an adenovirus early promoter RL Nucleic Acids Res. 15:8367-8385 (1987). RN [14] RA Dean D. C., Blakeley M. S., Newby R. F., Ghazal P., RA Hennighausen L., Bourgeois S. RT Forskolin Inducibility and Tissue-Specific Expression RT of the Fibronectin Promoter RL Mol. Cell. Biol. 9:1498-1506 (1989). RN [15] RA Suzuki T. RT - RL Proc. Natl. Acad. Sci. USA 90:610-614 (1993). RN [16] RA Grove RT - RL J. Biol. Chem. 264:19506-19513 (1989). RN [17] RA Jones K. W. RT - RL Cell 66:861-872 (1991). RN [18] RA Waeber G., Meyer T. E., LeSieur M., Hermann H. L., Gerard N., Habener J. F. RT Developmental stage specific expression of the cyclic RT AMP response element binding protein CREB during spermatogenesis RT involves alternative exon splicing RL Mol. Endocrinol. 5:1418-1430 (1991). RN [19] RA Loriaux M. M., Rehfuss R. R., Brennan R. G., Goodman R. H. RT Engineered leucine zippers show that hemiphosphorylated RT CREB complexes are transcritionally active RL Proc. Natl. Acad. Sci. USA 90:9046-9050 (1993). RN [20] RA Anderson M. G., Dynan W. S. RT Quantitative studies of the effect of HTLV-I Tax protein RT on CREB protein-DNA binding RL Nucleic Acids Res. 22:3194-3201 (1994). RN [21] RA Wheat W. H., Roesler W. J., Klemm D. J. RT Simian virus 40 small tumor antigen inhibits dephosphorylation RT of protein kinase A-phosphorylated CREB and regulates RT CREB transcriptional stimulation RL Mol. Cell. Biol. 14:5881-5890 (1994). RN [22] RA Yoshimura T., Fujisawa J., Yoshida M. RT Multiple cDNA clones encoding nuclear proteins that RT bind to the tax-dependent enhancer of HTLV-1: all RT contain a leucine zipper structure and basic amino acid domain RL EMBO J. 9:2537-2542 (1990). RN [23] RA Perini G., Wagner S., Green M. R. RT Recognition of bZIP proteins by the human T-cell leukemia RT virus transactivator Tax RL Nature 376:602-605 (1995). RN [24] RA Baranger A. M., Palmer C. R., Hamm M. K., Giebler RA H. A., Brauweiler A., Nyborg J. K., Schepartz A. RT Mechanism of DNA-binding enhancement by the human RT T-cell leukaemia virus transcativator Tax RL Nature 376:606-608 (1995). RN [25] RA Berkowitz L. A., Gilman M. Z. RT Two distinct forms of active transcription factor RT CREB (cAMP response element binding protein) RL Proc. Natl. Acad. Sci. USA 87:5258-5262 (1990). RN [26] RA Fink J. S., Verhave M., Walton K., Mandel G., Goodman R. H. RT Cyclic AMP- and phorbol ester-induced transcriptional RT activation are mediated by the same enhancer element RT in the human vasoactive intestinal peptide gene RL J. Biol. Chem. 266:3882-3887 (1991). RN [27] RA Hoeffler J. P., Meyer T. E., Yun Y., Jameson J. L., Habener J. F. RT Cyclic AMP-responsive DNA-binding protein: structure RT based on a cloned placental cDNA RL Science 242:1430-1433 (1988). RN [28] RA Hurst H. C., Masson M., Jones N. C., Lee K. A. W. RT The cellular transcription factor CREB corresponds RT to activating transcription factor 47 (ATF-47) and RT forms complexes with a group of polypeptides related to ATF-43 RL Mol. Cell. Biol. 10:6192-6203 (1990). XX // AC T00164 XX ID T00164 XX DT 15.10.92 (created); ewi. DT 04.03.97 (updated); ewi. XX FA CREB XX SY ATF-47 (human); CREB-341; CREB-B; CREBalpha; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.2.0.1.1. XX SZ 341 AA; 43 kDa (SDS), 37 kDa (cDNA) XX SQ MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN SQ GQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTD SQ SQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG SQ QYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQV SQ VVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAAREC SQ RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD XX SC SwissProt #P15337 XX FT 10 87 glutamine-rich region Q1 (17/88) FT 41 86 basal activation domain [1]; FT 98 142 PKA activation domain (phosphorylation at Ser-133) FT 176 253 glutamine-rich region Q2 (15/78) FT 165 252 basal activation domain [1]; FT 284 309 basic region FT 311 332 leucine zipper (L4) FT 282 284 AAR, critical for interaction with Tax [13]; XX SF multiple splice variants [3], [32]; SF pI (cal.)=5.7-6.0 [24]; SF leucine zipper-independent binding of coactivator CBP [8]; SF the Tax activator of HTLV-I interacts with the basic SF region [39] decreasing the dissociation constant for SF CREB homodimers (from 7 nM to 0.1 nM) and for (CREB)2-DNA SF complexes (from 60 nM to 14.4 nM) [35] and altering SF the DNA binding selectivity [39]; SF both Q1 and DLSSD motif are required for full basal SF and induced transcription activation [42], [1], as is Q2 [1]; SF the activity of Q2 is repressed by KID (kinase-induced SF domain) unless KID is phosphorylated at Ser-133 [18], [22], [1]; SF deletion of KID enhances both basal and induced transcription [1]; SF the amphiphilic alpha-helical alpha domain is thought SF to augment the activation process [44]; SF dephosphorylation may be achieved by the nuclear phosphatase PP1 [27]; XX CP spleen, heart, thymus, gut, brain, kidney; very weak CP expression in testis and liver XX FF cAMP-dependent phosphorylation by PKA leads to induction FF of trans-activation [40], [28], [30]; FF PKA regulatory subunit RIalpha is encoded by the tissue-specific FF extinguisher locus, Tse1, which mediates deactivation of CREB [20]; FF also phosphorylation of Ser-133 by CaM kinases I, FF II, and IV in vitro and after membrane depolarization FF in PC12 cells [45], [25], [36]; FF CamK II also phosphorylates Ser-142 which counteracts FF the activating phosphorylation at Ser-133 [36], [37]; FF light exposure triggers Ser-133 phosphorylation within FF suprachiasmatic nuclei in the hypothalamus controlling FF the circadian rhythm [4]; FF phosphorylation-dependent change in genomic binding FF status is observed at asymmetric, low-affinity sites only [6]; FF if not phosphorylated, CREB may act as a repressor [22]; FF mediates NO-amplified calcium-induced transcription [2]; FF significant enhancement of dimerization by Tax; FF may also inhibit activity of some unrelated factors [12]; FF splice variant: deltaCREB; FF testis-specific splice product with multiple stop FF codons within its alternative exon; FF in glioma cells, transcription of the CREB gene is FF induced by glucocorticoids [26]; FF CREB may synergize with Isl-1 (T01035) rendering activation FF independent of CREB phosphorylation [5]; XX IN T00051; ATF; human, Homo sapiens. IN T00164; CREB; rat, Rattus norvegicus. IN T00165; deltaCREB; rat, Rattus norvegicus. IN T00166; deltaCREB; human, Homo sapiens. IN T00793; Tax; HTLV-I, human T-cell lymphotropic virus type I. IN T00968; ATF-1; human, Homo sapiens. IN T01304; ATF-1; mouse, Mus musculus. IN T01305; CBP100; mouse, Mus musculus. IN T01311; deltaCREB; mouse, Mus musculus. IN T01314; CREMalpha; mouse, Mus musculus. IN T01318; CBP; mouse, Mus musculus. IN T01319; ICER; rat, Rattus norvegicus. IN T01381; deltaCREB; mink, Mustela vison. IN T01384; pX; EBV, Epstein-Barr virus. IN T01600; CREMdeltaC-G; rat, Rattus norvegicus. XX MX M00039; V$CREB_01 MX M00113; V$CREB_02 MX M00114; V$TAXCREB_01 MX M00115; V$TAXCREB_02 XX BS R00322; AD$E2AE1_07; Quality: 6; adenovirus type 2 BS R00362; AD$E4_16; Quality: 6; adenovirus type 5 BS R01196; BOVIN$PTH_01; Quality: 4; cattle, Bos taurus BS R04110; CREB$CONS_01; Quality: 2 BS R00471; HS$CFOS_14; Quality: 2; human, Homo sapiens BS R00288; HS$DPOLB_02; Quality: 4; human, Homo sapiens BS R00592; HS$GHA_02; Quality: 4; human, Homo sapiens BS R03738; HS$PTH_01; Quality: 6; human, Homo sapiens BS R01559; HS$VIP_01; Quality: 2; human, Homo sapiens BS R00777; HT1$HTLV1_01; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R00779; HT1$HTLV1_03; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R04032; MOUSE$CJUN_03; Quality: 1; mouse, Mus musculus BS R00963; MOUSE$LDHA_01; Quality: 4; mouse, Mus musculus BS R02456; RAT$GLU_05; Quality: 2; rat, Rattus norvegicus BS R01217; RAT$PEPCK_06; Quality: 1; rat, Rattus norvegicus BS R01358; RAT$SSTA_01; Quality: 1; rat, Rattus norvegicus BS R03401; RAT$TAT_27; Quality: 2; rat, Rattus norvegicus XX DR EMBL: X14788; RNCREB(r). DR SwissProt: P15337; CREB_RAT. DR PIR: S03343; S03343. DR Compel: C00129 XX RN [1] RA Quinn P. G. RT Distinct activation domains within cAMP response element-binding RT protein (CREB) mediate basal and cAMP-stimulated transcription RL J. Biol. Chem. 268:16999-17009 (1993). RN [2] RA Peunova N., Enikolopov G. RT Amplification of calcium-induced gene transcription RT by nitric oxide in neuronal cells RL Nature 364:450-452 (1993). RN [3] RA Waeber G., Habener J. F. RT Novel testis germ cell-specific transcript of the RT CREB gene contains an alternatively spliced exon with RT multiple in-frame stop codons RL Endocrinology 131:2010-2015 (1992). RN [4] RA Ginty D. D., Kornhauser J. M., Thompson M. A., Bading RA H., Mayo K. E., Takahashi J. S., Greenberg M. E. RT Regulation of CREB phosphorylation in the suprachiasmatic RT nucleus by light and a circadian clock RL Science 260:238-241 (1993). RN [5] RA Leonhard J., Serup P., Gonzalez G., Edlund T., Montminy M. RT The LIM family transcription factor Isl-1 requires RT cAMP response element binding protein to promote somatostatin RT expression in pancreatic islet cells RL Proc. Natl. Acad. Sci. USA 89:6247-6251 (1992). RN [6] RA Nichols M., Weih F., Schmid W., DeVack C., Kowenz-Leutz RA E., Luckow B., Boshart M., Schuetz G. RT Phosphorylation of CREB affects its binding to high RT and low affinity sites: implications for cAMP induced gene transcription RL EMBO J. 11:3337-3346 (1992). RN [7] RA Foulkes N. S., Borrelli E., Sassone-Corsi P. RT CREM gene: use of alternative DNA-binding domains RT generates multiple antagonists of cAMP-induced transcription RL Cell 64:739-749 (1991). RN [8] RA Chrivia J. C., Kwok R. P. S., Lamb N., Hagiwara M., RA Montminy M. R., Goodman R. H. RT Phosphorylated CREB binds specifically to the nuclear protein CBP RL Nature 365:855-859 (1993). RN [9] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [10] RA Stehle J. H., Foulkes N. S., Molina C. A., Simonneaux RA V., Pevet P., Sassone-Corsi P. RT Adrenergic signals direct rhythmic expression of transcriptional RT repressor CREM in the pineal gland RL Nature 365:314-320 (1993). RN [11] RA Miller C. P., Lin J. C., Habener J. F. RT Transcription of the rat glucagon gene by the cyclic RT AMP response element-binding protein CREB is modulated RT by adjacent CREB-associated proteins RL Mol. Cell. Biol. 13:7080-7090 (1993). RN [12] RA Lemaigre F. P., Ace C. I., Green M. R. RT The cAMP response element binding protein, CREB, is RT a potent inhibitor of diverse transcriptional activators RL Nucleic Acids Res. 21:2907-2911 (1993). RN [13] RA Adya N., Zhao L.-J., Huang W., Boros I., Giam C.-Z. RT Expansion of CREB's DNA recognition specificity by RT Tax results from interaction with Ala-Ala-Arg at positions RT 282-284 near the conserved DNA-binding domain of CREB RL Proc. Natl. Acad. Sci. USA 91:5642-5646 (1994). RN [14] RA Montminy M. R., Bilezikjian L. M. RT Binding of a nuclear protein to the cyclic-AMP response RT element of the somatostatin gene RL Nature 328:175-178 (1987). RN [15] RA Kanei-Ishii C., Ishii S. RT Dual enhancer activities of the cyclic-AMP responsive RT element with cell type and promoter specificity RL Nucleic Acids Res. 17:1521-1536 (1989). RN [16] RA Gonzalez G. A., Yamamoto K. K., Fischer W. H., Karr RA D., Menzel P., Biggs III W., Vale W. W., Montminy M. R. RT A cluster of phosphorylation sites on the cyclic AMP-regulated RT nuclear factor CREB predicted by its sequence RL Nature 337:749-752 (1989). RN [17] RA Montminy M. R., Sevarino K. A., Wagner J. A., Mandel G., Goodman R. H. RT Identification of a cyclic-AMP-responsive element RT within the rat somatostatin gene RL Proc. Natl. Acad. Sci. USA 83:6682-6686 (1986). RN [18] RA Gonzalez G. A., Montminy M. R. RT Cyclic AMP stimulates somatostatin gene transcription RT by phosphorylation of CREB at serine 133 RL Cell 59:675-680 (1989). RN [19] RA Dash P. K., Hochner B., Kandel E. R. RT Injection of the cAMP-responsive element into the RT nucleus of Aplysia sensory neurons blocks long-term facilitation RL Nature 345:719-721 (1990). RN [20] RA Boshart M., Weih F., Schmidt A., Fournier R. E. K., Schuetz G. RT A cyclic AMP response element mediates repression RT of tyrosine aminotransferase gene transcription by RT the tissue-specific extinguisher locus Tse-1 RL Cell 61:905-916 (1990). RN [21] RA Weih F., Stewart A. F., Boshart M., Nitsch D., Schuetz G. RT In vivo monitoring of a cAMP-stimulated DNA-binding activity RL Genes Dev. 4:1437-1449 (1990). RN [22] RA Lamph W. W., Dwarki V. J., Ofir R., Montminy M., Verma I. M. RT Negative and positive regulation by transcription RT factor cAMP response element-binding protein is modulated by phosphorylation RL Proc. Natl. Acad. Sci. USA 87:4320-4324 (1990). RN [23] RA Boshart M., Weih F., Nichols M., Schuetz G. RT The tissue-specific extinguisher locus TSE1 encodes RT a regulatory subunit of cAMP-dependent protein kinase RL Cell 66:849-859 (1991). RN [24] RA Kramer I. M., Koornneef I., de Laat S. W., van den RA Eijnden-van Raaij A. J. M. RT TGF-beta1 induces phosphorylation of the cyclic AMP RT responsive element binding protein in ML-CCI64 cells RL EMBO J. 10:1083-1089 (1991). RN [25] RA Dash P. K., Karl K. A., Colicos M. A., Prywes R., Kandel E. R. RT cAMP response element-binding protein is activated RT by Ca2+/calmodulin- as well as cAMP-dependent protein kinase RL Proc. Natl. Acad. Sci. USA 88:5061-5065 (1991). RN [26] RA Jungmann R. A. RT Glucocorticoid induction RL Nucleic Acids Res. 20:825-829 (1992). RN [27] RA Hagiwara M., Alberts A., Brindle P., Meinkoth J., RA Feramisco J., Deng T., Karin M., Shenolikar S., Montminy M. RT Transcriptional Attenuation Following cAMP Induction RT Requires PP-1-Mediated Dephosphorylation of CREB RL Cell 70:105-113 (1992). RN [28] RA Riabowol K.T., Fink J.S., Gilman M.Z., Walsh D.A., RA Goodman R.H., Feramisco J.R. RT The catalytic subunit of cAMP-dependent protein kinase RT induces expression of genes containing cAMP-responsive enhancer elements RL Nature 336:83-86 (1988). RN [29] RA Laoide B.M., Foulkes N.S., Schlotter F., Sassone-Corsi P. RT The functional versatility of CREM is determined by its modular structure RL EMBO J. 12:1179-1191 (1993). RN [30] RA Mellon P. L., Clegg C. H., Correll L. A., McKnight G. S. RT Regulation of transcription by cyclic AMP-dependent protein kinase RL Proc. Natl. Acad. Sci. USA 86:4887-4891 (1989). RN [31] RA Struthers RT - RL Nature 350:622-624 (1991). RN [32] RA Waeber G., Meyer T. E., LeSieur M., Hermann H. L., Gerard N., Habener J. F. RT Developmental stage specific expression of the cyclic RT AMP response element binding protein CREB during spermatogenesis RT involves alternative exon splicing RL Mol. Endocrinol. 5:1418-1430 (1991). RN [33] RA Hagiwara RT - RL Mol. Cell. Biol. 13:4852-4859 (1993). RN [34] RA Spiro RT - RL Proc. Natl. Acad. Sci. USA 90:4046-4610 (1993). RN [35] RA Anderson M. G., Dynan W. S. RT Quantitative studies of the effect of HTLV-I Tax protein RT on CREB protein-DNA binding RL Nucleic Acids Res. 22:3194-3201 (1994). RN [36] RA Sun P., Enslen H., Myung P. S., Maurer R. A. RT Differential activation of CREB by Ca2+/calmodulin-dependent RT protein kinases type II and type IV involves phosphorylation RT of a site that negatively regulates activity RL Genes Dev. 8:2527-2539 (1994). RN [37] RA Matthews R. P., Guthrie C. R., Wailes L. M., Zhao RA X., Means A. R., McKnight G. S. RT - RL Mol. Cell. Biol. 14:6107-6116 (1994). RN [38] RA Ginty D. D., Bonni A., Greenberg M. E. RT Nerve growth factor activates a Ras-dependent protein RT kinase that stimulates c-fos transcription via phosphorylation of CREB RL Cell 77:713-725 (1994). RN [39] RA Perini G., Wagner S., Green M. R. RT Recognition of bZIP proteins by the human T-cell leukemia RT virus transactivator Tax RL Nature 376:602-605 (1995). RN [40] RA Yamamoto K. K., Gonzalez G. A., Biggs III W. H., Montminy M. R. RT Phosphorylation-induced binding and transcriptional RT efficacy of nuclear factor CREB RL Nature 334:494-498 (1988). RN [41] RA Bokar J. A., Roesler W. J., Vandenbark G. R., Kaetzel RA D. M., Hanson R. W., Nilson J. H. RT Characterization of the cAMP Responsive Elements from RT the Genes for the alpha-Subunit of Glycoprotein Hormones RT and Phosphoenolpyruvate Carboxykinase (GTP) RL J. Biol. Chem. 263:19740-19747 (1988). RN [42] RA Gonzalez G. A., Menzel P., Leonard J., Fisher W. H., Montminy M. R. RT Characterization of motifs which are critical for RT activity of the cyclic AMP-responsive transcription factor CREB RL Mol. Cell. Biol. 11:1306-1312 (1991). RN [43] RA Quinn P. G., Granner D. K. RT Cyclic AMP-dependent protein kinase regulates transcription RT of the phosphoenolpyruvate carboxykinase gene but RT not binding of nuclear factors to the cyclic AMP regulatory element RL Mol. Cell. Biol. 10:3357-3364 (1990). RN [44] RA Yamamoto K. K., Gonzalez G. A., Menzel P., Rivier J., Montminy M. R. RT Characterization of a bipartite activator domain in RT transcription factor CREB RL Cell 60:611-617 (1990). RN [45] RA Sheng M., Thompson M. A., Greenberg M. E. RT CREB: A Ca2+-regulated transcription factor phosphorylated RT by calmodulin-dependent kinases RL Science 252:1427-1430 (1991). XX // AC T00165 XX ID T00165 XX DT 01.06.93 (created); ewi. DT 09.06.97 (updated); ewi. XX FA deltaCREB XX SY CREB-327; CREB-A; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.2.0.1.2. XX SZ 327 AA; 35 kDa (cDNA) XX SQ MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN SQ GQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSY SQ RKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLA SQ NNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQI SQ RTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENR SQ VAVLENQNKTLIEELKALKDLYCHKSD XX SC edited SwissProt #P15337 XX FT 1 87 glutamine-rich region Q1 (17/87) FT 92 108 serine-rich phosphorylated heptadecamer (5/17) FT 101 140 KID FT 121 131 required for trans-activation FT 140 248 glutamine-rich region Q2 (15/108) FT 270 295 basic region FT 297 318 leucine zipper (L4) FT 119 119 Ser-phosphorylation XX SF K289 and K291: important for DNA-binding [2]; XX CP ubiquitous (placenta) XX FF splice variant from CREB (AA 88-101 of CREB missing); FF only 10% trans-activation capability compared to CREB; FF transcription is induced by glucocorticoids (glioma cells) [3]; XX IN T00163; CREB; human, Homo sapiens. IN T00164; CREB; rat, Rattus norvegicus. IN T00165; deltaCREB; rat, Rattus norvegicus. IN T00989; CREB; mouse, Mus musculus. IN T01127; CREB; domestic pig, Sus scrofa. IN T01307; CREB; hamster. IN T01380; CREB; mink, Mustela vison. IN T01385; CREB; cattle, Bos taurus. XX MX M00039; V$CREB_01 MX M00113; V$CREB_02 MX M00114; V$TAXCREB_01 MX M00115; V$TAXCREB_02 XX BS R04110; CREB$CONS_01; Quality: 2 BS R00963; MOUSE$LDHA_01; Quality: 6; mouse, Mus musculus BS R01358; RAT$SSTA_01; Quality: 6; rat, Rattus norvegicus XX DR EMBL: X14788; RNCREB(g). DR SwissProt: P15337; CREB_RAT. XX RN [1] RA Quinn P. G. RT Distinct activation domains within cAMP response element-binding RT protein (CREB) mediate basal and cAMP-stimulated transcription RL J. Biol. Chem. 268:16999-17009 (1993). RN [2] RA Andrisani O. M., Dixon J. E. RT Involvement of lysine residues 289 and 291 of the RT cAMP-responsive element-binding protein in the recognition RT of the cAMP-responsive element RL J. Biol. Chem. 266:21444-21450 (1991). RN [3] RA Jungmann R. A. RT Glucocorticoid induction RL Nucleic Acids Res. 20:825-829 (1992). RN [4] RA Quinn P. G., Granner D. K. RT Cyclic AMP-dependent protein kinase regulates transcription RT of the phosphoenolpyruvate carboxykinase gene but RT not binding of nuclear factors to the cyclic AMP regulatory element RL Mol. Cell. Biol. 10:3357-3364 (1990). RN [5] RA Yamamoto K. K., Gonzalez G. A., Menzel P., Rivier J., Montminy M. R. RT Characterization of a bipartite activator domain in RT transcription factor CREB RL Cell 60:611-617 (1990). RN [6] RA Berkowitz L. A., Gilman M. Z. RT Two distinct forms of active transcription factor RT CREB (cAMP response element binding protein) RL Proc. Natl. Acad. Sci. USA 87:5258-5262 (1990). XX // AC T00166 XX ID T00166 XX DT 01.06.93 (created); ewi. DT 28.01.97 (updated); hiwi. XX FA deltaCREB XX SY CREB-327; CREB-A; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO ATF-43 XX CL C0008; bZIP; . XX SZ 327 AA; 35 kDa (cDNA) XX SQ MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN SQ GQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSY SQ RKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLA SQ NNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQI SQ RTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENR SQ VAVLENQNKTLIEELKALKDLYCHKSD XX SC edited SwissProt #P16220 XX FT 1 87 glutamine-rich region Q1 (17/87) FT 101 140 KID FT 140 248 glutamine-rich region Q2 (15/108) FT 270 295 basic region FT 297 318 leucine zipper (L4) FT 92 137 minimal essential module, P-box FT 92 108 required for cAMP-inducible transactivation; FT serine-rich phosphorylated heptadecamer (5/17) FT 119 119 serine phosphorylated by PKA FT 121 131 required for cAMP-inducible transactivation XX SF basic region SF zipper (L4) XX CP ubiquitous (placenta) XX FF splice variant from CREB (AA 88-101 of CREB missing); FF only 10% trans-activation capability compared to CREB XX IN T00051; ATF; human, Homo sapiens. IN T00163; CREB; human, Homo sapiens. IN T00164; CREB; rat, Rattus norvegicus. IN T00166; deltaCREB; human, Homo sapiens. IN T00968; ATF-1; human, Homo sapiens. IN T00989; CREB; mouse, Mus musculus. IN T01127; CREB; domestic pig, Sus scrofa. IN T01304; ATF-1; mouse, Mus musculus. IN T01307; CREB; hamster. IN T01380; CREB; mink, Mustela vison. IN T01385; CREB; cattle, Bos taurus. XX MX M00039; V$CREB_01 MX M00113; V$CREB_02 MX M00114; V$TAXCREB_01 MX M00115; V$TAXCREB_02 XX BS R00352; AD$E4_06; Quality: 2; adenovirus BS R00362; AD$E4_16; Quality: 6; adenovirus type 5 BS R04110; CREB$CONS_01; Quality: 2 XX DR EMBL: S72459; S72459(g). DR SwissProt: P16220; CREB_HUMAN. XX RN [1] RA Rehfuss R. P., Walton K. M., Loriaux M. M., Goodman R. H. RT The cAMP-regulated enhancer-binding protein ATF-1 RT activates transcription in response to cAMP-dependent protein kinase A RL J. Biol. Chem. 266:18431-18434 (1991). RN [2] RA Yoshimura T., Fujisawa J.-I., Yoshida M. RT Multiple cDNA clones encoding nuclear proteins that RT bind to the tax-dependent enhancer of HTLV-1: all RT contain a leucine zipper structure and basic amino acid domain RL EMBO J. 9:2537-2542 (1990). RN [3] RA Kerppola T. K., Curran T. RT Selective DNA bending by a variety of bZIP proteins RL Mol. Cell. Biol. 13:5479-5489 (1993). RN [4] RA Krajewski W., Lee K. A. W. RT A monomeric derivative of the cellular transcription RT factor CREB functions as a constitutive activator RL Mol. Cell. Biol. 14:7204-7210 (1994). RN [5] RA Quinn P. G., Granner D. K. RT Cyclic AMP-dependent protein kinase regulates transcription RT of the phosphoenolpyruvate carboxykinase gene but RT not binding of nuclear factors to the cyclic AMP regulatory element RL Mol. Cell. Biol. 10:3357-3364 (1990). RN [6] RA Yamamoto K. K., Gonzalez G. A., Menzel P., Rivier J., Montminy M. R. RT Characterization of a bipartite activator domain in RT transcription factor CREB RL Cell 60:611-617 (1990). RN [7] RA Berkowitz L. A., Gilman M. Z. RT Two distinct forms of active transcription factor RT CREB (cAMP response element binding protein) RL Proc. Natl. Acad. Sci. USA 87:5258-5262 (1990). RN [8] RA Hoeffler J. P., Meyer T. E., Yun Y., Jameson J. L., Habener J. F. RT Cyclic AMP-responsive DNA-binding protein: structure RT based on a cloned placental cDNA RL Science 242:1430-1433 (1988). RN [9] RA Lee Q. C., Yun Y., Hoeffler J. P., Habener J. F. RT Cyclic-AMP-responsive transcriptional activation of RT CREB-327 involves interdependent phosphorylated subdomains RL EMBO J. 9:4455-4465 (1990). RN [10] RA Hurst H. C., Masson M., Jones N. C., Lee K. A. W. RT The cellular transcription factor CREB corresponds RT to activating transcription factor 47 (ATF-47) and RT forms complexes with a group of polypeptides related to ATF-43 RL Mol. Cell. Biol. 10:6192-6203 (1990). XX // AC T00167 XX ID T00167 XX DT 15.10.92 (created); ewi. DT 07.05.97 (updated); ewi. XX FA CRE-BP1 XX SY ATF-2; HB16; TREB-7; XBP4 (mouse); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0008; bZIP; 1.1.1.6.3.1. XX SZ 505 AA; 54.5 kDa (cDNA), 69 kDa (SDS) XX SQ MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARN SQ DSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIR SQ SKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSD SQ SSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPSGQTMPVAIPASITSSNV SQ HVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGS SQ GLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLE SQ RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPV SQ TAMQKKSGYHTADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQM SQ ADQSTEPALSQIVMAPSSQSQPSGS XX SC SwissProt #P15336 XX FT 1 143 region supporting E1A responsiveness [20]; FT 27 49 potential zinc finger (Cys2His2 type) [20]; FT 62 62 serine, PKA phosphorylation site in vitro [11]; FT 100 100 potential PKA phosphorylation site [15]; FT 121 121 potential PKC phosphorylation site [15]; FT 150 247 missing in CRE-BP2 [16]; FT 320 340 serine-/threonine-rich region (12/21) FT 340 340 serine, PKC phosphorylation site in vitro [11]; FT 353 377 basic region [15]; FT 367 367 serine, PKC phosphorylation site in vitro [11]; FT 380 408 leucine zipper (L5) [15]; FT 387 417 serine-/threonine-rich region (15/31) XX SF Tax interacts with the basic domain and thereby enhances SF homodimerization [6], [17], [18]; SF this contact alters also the DNA-binding selectivity [17]; SF the zinc finger structure is important for trans-activation SF by the homodimer [2]; SF bound to DNA, CRE-BP1 interacts with E1A via N-terminal SF regions comprising the zinc finger motif as essential element [20], [10]; SF in the heterodimer with c-Jun, trans-activation is SF mainly achieved by the c-Jun moiety [2]; SF no heterodimerization with deltaCREB [7]; SF DNA-bending towards the minor groove when heterodimerized SF with c-Fos or Fra-2 [5]; SF with c-Jun: beinding in the opposite direction, similar SF to that caused by CRE-BP1 homodimers [5]; XX CP human (mRNA): widespread expression: cerebellum, kidney, CP lung, meninges, muscle, spinal cord, spleen, stomach, CP thymus; most abundant in brain; very low levels in CP thalamus, adernal gland [22]; CN not found in the amygdala, heart, liver [22]; XX FF activator, cAMP-independent [2]; FF lacking constitutive activation capability according to [20]; FF stronger activator as heterodimer with c-Jun than as homodimer [2]; FF in vitro phosphorylation by PKA and PKC, function unclear; FF phosphorylation by a JNK/SAPK kinase of the MAPK family FF at Thr-69 and -71 mediates activation in response FF to UV or other cellular stresses [19]; FF transcriptional activation is stimulated by Rb involving FF CRE-BP1 in cell cycle control [4]; FF interacts with E1A and places its transactivation FF domain at a viral promoter; FF mediates E1A-induced trans-activation through the FF potential zinc finger (part. important: C27 and C32) FF and the leucine zipper (in particular 3rd and 4th Leu) [20], [10]; FF altered DNA-binding specificity after complexing with FF HBV pX [9] or with HTLV-I Tax [6]; XX IN T00051; ATF; human, Homo sapiens. IN T00123; c-Fos; human, Homo sapiens. IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T00167; CRE-BP1; human, Homo sapiens. IN T00209; E1A 13S protein; adenovirus type 2. IN T00593; NF-kappaB1; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T00722; Rb; human, Homo sapiens. IN T00793; Tax; HTLV-I, human T-cell lymphotropic virus type I. IN T00967; E1A 12S protein; adenovirus. IN T01017; CRE-BP2; mouse, Mus musculus. IN T01308; CRE-BPa; human, Homo sapiens. IN T01313; ATF-3; human, Homo sapiens. IN T01384; pX; EBV, Epstein-Barr virus. IN T01991; Fra-2; human, Homo sapiens. XX MX M00040; V$CREBP1_01 MX M00041; V$CREBP1CJUN_01 XX BS R00343; AD$E3_05; Quality: 6; adenovirus type 2 BS R00349; AD$E4_03; Quality: 2; adenovirus BS R00352; AD$E4_06; Quality: 2; adenovirus BS R00356; AD$E4_10; Quality: 2; adenovirus type 5 BS R00362; AD$E4_16; Quality: 6; adenovirus type 5 BS R03910; AS$AP1_07; Quality: 2 BS R03924; AS$AP1_08; Quality: 6 BS R03433; AS$ATF_03; Quality: 2 BS R03909; AS$CRE_02; Quality: 2 BS R04111; CREBP1$CONS_01; Quality: 2 BS R04112; CRPJUN$CONS_01; Quality: 2 BS R04045; HBV$HBVE_27; Quality: 2; HBV, human hepatitis B virus BS R00807; HCMV$IE1_21; Quality: 2; hCMV, human cytomegalovirus BS R00471; HS$CFOS_14; Quality: 6; human, Homo sapiens BS R02427; HS$CREBP1_05; Quality: 2; human, Homo sapiens BS R02437; HS$CREBP1_15; Quality: 2; human, Homo sapiens BS R00288; HS$DPOLB_02; Quality: 5; human, Homo sapiens BS R00455; HS$FN_02; Quality: 2; human, Homo sapiens BS R00592; HS$GHA_02; Quality: 6; human, Homo sapiens BS R01258; HS$PK_03; Quality: 6; human, Homo sapiens BS R03918; HS$TGFB2_01; Quality: 2; human, Homo sapiens BS R01559; HS$VIP_01; Quality: 6; human, Homo sapiens BS R00777; HT1$HTLV1_01; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R00479; MOUSE$CFOS_08; Quality: 6; mouse, Mus musculus BS R01067; MOUSE$M2IAA_01; Quality: 6; mouse, Mus musculus BS R01358; RAT$SSTA_01; Quality: 2; rat, Rattus norvegicus BS R01383; SV$SV40_15; Quality: 6; SV40, simian virus 40 XX DR EMBL: X15875; HSCREBP1(r). DR SwissProt: P15336; CREP_HUMAN. DR PIR: S05380; S05380. DR Compel: C00092 DR Compel: C00093 DR Compel: C00094 DR Compel: C00099 XX RN [1] RA Jones C., Lee K. A. W. RT E1A-mediated activation of the adenovirus E4 promoter RT can occur independently of the cellular transcription factor E4F RL Mol. Cell. Biol. 11:4297-4305 (1991). RN [2] RA Matsuda S., Maekawa T., Ishii S. RT Identification of the functional domains of the transcriptional RT regulator CRE-BP1 RL J. Biol. Chem. 266:18188-18193 (1991). RN [3] RA Nomura N., Zu Y.-L., Maekawa T., Tabata S., Akiyama T., Ishii S. RT Isolation and characterization of a novel member of RT the gene family encoding the cAMP response element-binding protein CRE-BP1 RL J. Biol. Chem. 268:4259-4266 (1993). RN [4] RA Kim S.-J., Wagner S., Liu F., O'Reilly M. A., Robbins P. D., Green M. R. RT Retinoblastoma gene product activates expressionof RT the human TGF-beta2 gene through transcription factor ATF-2 RL Nature 358:331-334 (1992). RN [5] RA Hai T., Curran T. RT Cross-family dimerization of transcription factors RT Fos/Jun and ATF/CREB alters DNA binding specificity RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991). RN [6] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [7] RA Benbrook D. M., Jones N. C. RT Heterodimer formation between CREB and JUN proteins RL Oncogene 5:295-302 (1990). RN [8] RA Maguire K., Shi X.-P., Horikoshi N., Rappaport J., Rosenberg M., Weinmann R. RT Interactions between adenovirus E1A and members of RT the AP-1 family of cellular transcription factors RL Oncogene 6:1417-1422 (1991). RN [9] RA Maguire H. F., Hoeffler J. P., Siddiqui A. RT HBV X protein alters the DNA binding specificity of RT CREB and ATF-2 by protein-protein interactions RL Science 252:842-844 (1991). RN [10] RA Zu Y.-L., Maekawa T., Matsuda S., Ishii S. RT Complete putative metal finger and leucine zipper RT structures of CRE-BP1 are required for the E1A-induced trans-activation RL J. Biol. Chem. 266:24134-24139 (1991). RN [11] RA Sakurai A., Maekawa T., Sudo T., Ishii S., Kishimoto A. RT Phosphorylation of cAMP response element-binding protein, RT CRE-BP1, by cAMP-dependent protein kinase and protein kinase c* RL Biochem. Biophys. Res. Commun. 181:629-635 (1991). RN [12] RA Yoshimura T., Fujisawa J.-I., Yoshida M. RT Multiple cDNA clones encoding nuclear proteins that RT bind to the tax-dependent enhancer of HTLV-1: all RT contain a leucine zipper structure and basic amino acid domain RL EMBO J. 9:2537-2542 (1990). RN [13] RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., RA DeRaemy-Schenk A.-M., Chen B. P. C., Hai T., DeLamarter J. F., Whelan J. RT Cyclic AMP-independent ATF family members interact RT with NF-kappaB and function in the activation of the RT E-selectin promoter in response to cytokines RL Mol. Cell. Biol. 13:7180-7190 (1993). RN [14] RA Kerppola T. K., Curran T. RT Selective DNA bending by a variety of bZIP proteins RL Mol. Cell. Biol. 13:5479-5489 (1993). RN [15] RA Maekawa T., Sakura H., Kanei-Ishii C., Sudo T., Yoshimura RA T., Fujisawa J.-I., Yoshida M., Ishii S. RT Leucine zipper structure of the protein CRE-BP1 binding RT to the cyclic AMP response element in brain RL EMBO J. 8:2023-2328 (1989). RN [16] RA Ivashkiv L. B., Liou H.-C., Kara C. J., Lamph W. W., RA Verma I. M., Glimcher L. H. RT mXBP/CRE-BP2 and c-Jun form a complex which binds RT to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, RT response element RL Mol. Cell. Biol. 10:1609-1621 (1990). RN [17] RA Perini G., Wagner S., Green M. R. RT Recognition of bZIP proteins by the human T-cell leukemia RT virus transactivator Tax RL Nature 376:602-605 (1995). RN [18] RA Baranger A. M., Palmer C. R., Hamm M. K., Giebler RA H. A., Brauweiler A., Nyborg J. K., Schepartz A. RT Mechanism of DNA-binding enhancement by the human RT T-cell leukaemia virus transcativator Tax RL Nature 376:606-608 (1995). RN [19] RA van Dam H., Wilhelm D., Herr I., Steffen A., Herrlich P., Angel P. RT ATF-2 is preferentially activated by stress-activated RT protein kinases to mediate c-jun induction in response to genotoxic agents RL EMBO J. 14:1798-1811 (1995). RN [20] RA Liu F., Green M. R. R. RT A specific member of the ATF transcription factor RT family can mediate transcription activation by the adenovirus E1a protein RL Cell 61:1217-1224 (1990). RN [21] RA Hai T., Liu F., Coukos W. J., Green M. R. RT Transcription factor ATF cDNA clones: an extensive RT family of leucine zipper proteins able to selectively RT form DNA-binding heterodimers RL Genes Dev. 3:2083-2090 (1989). RN [22] RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H. RT A cDNA for a human cyclic AMP response element-binding RT protein which is distinct from CREB and expressed preferentially in brain RL Mol. Cell. Biol. 10:1347-1357 (1990). XX // AC T00168 XX ID T00168 XX DT 15.10.92 (created); ewi. DT 05.11.96 (updated); ewi. XX FA c-Rel XX SY HIVEN86A; p68; p82(hc-rel); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0020; Rel; 4.1.1.0.5. XX SZ 619 AA; 68.5 kDa (cDNA), 82-85 kDa (SDS) [16]; XX SQ MASGAYNPYIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQIMNYYGKGK SQ VRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGQERRPLFFQNLGIRCVKKKEVKEAII SQ TRIKAGINPFNVPEKQLNDIEDCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPIYDNRA SQ PNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGIFSQADVHRQV SQ AIVFKTPPYCKAITEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDTYGNKAKKQKTTLLF SQ QKLCQDHVETGFRHVDQDGLELLTSGDPPTLASQSAGITVNFPERPRPGLLGSIGEGRYF SQ KKEPNLFSHDAVVREMPTGVSSQAESYYPSPGPISSGLSHHASMAPLPSSSWSSVAHPTP SQ RSGNTNPLSSFSTRTLPSNSQGIPPFLRIPVGNDLNASNACIYNNADDIVGMEASSMPSA SQ DLYGISDPNMLSNCSVNMMTTSSDSMGETDNPRLLSMNLENPSCNSVLDPRDLRQLHQMS SQ SSSMSAGANSNTTVFVSQSDAFEGSDFSCADNSMINESGPSNSTNPNSHGFVQDSQYSGI SQ GSMQNEQLSDSFPYEFFQV XX SC SwissProt #Q04864 XX FT 8 295 Rel homology region XX SF overlapping DNA-binding specificity with NF-kappaB SF exclusive binding to, e. g., intronic enhancer of SF IFN-gamma gene (AGGGATTT) [10]; SF trans-activation through physical interaction with TBP [12]; XX CP (HeLa) XX FF potent activator as homo- or heterodimer with RelA FF [9], [14], but may also repress trans-activation by induced RelA [8]; FF relA gene is activated by RelA, but repressed by c-Rel itself [8]; FF DNA-binding by c-Rel is induced by HTLV-I Tax [11] FF which abrogates the negative feed-back regulation [8]; XX IN T00168; c-Rel; human, Homo sapiens. IN T00394; NF-kappaB2; human, Homo sapiens. IN T00416; IkappaB-beta; chick, Gallus gallus. IN T00587; NF-kappaB; rat, Rattus norvegicus. IN T00588; NF-kappaB; mouse, Mus musculus. IN T00590; NF-kappaB; human, Homo sapiens. IN T00593; NF-kappaB1; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T00595; RelA; mouse, Mus musculus. IN T00794; TBP; human, Homo sapiens. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00971; IkappaB-beta; mouse, Mus musculus. IN T01924; NF-kappaB1 precursor; mouse, Mus musculus. IN T01925; NF-kappaB1 precursor; human, Homo sapiens. IN T01927; NF-kappaB2 precursor; human, Homo sapiens. IN T01929; NF-kappaB2 precursor; chick, Gallus gallus. XX MX M00053; V$CREL_01 XX BS R01748; AS$NFKB_01; Quality: 2 BS R00699; HIV1$HIV1_06; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R02173; HIVEN86A$CONS; Quality: 6 BS R00940; HS$IL2RA_01; Quality: 5; human, Homo sapiens BS R00941; HS$IL2RA_02; Quality: 2; human, Homo sapiens BS R00943; HS$IL2RA_04; Quality: 6; human, Homo sapiens BS R01058; MOUSE$M1H2KB_06; Quality: 6; mouse, Mus musculus XX DR EMBL: M11595; HSCRELA(g). DR EMBL: X75042; HSRNAREL(r). DR SwissProt: Q04864; REL_HUMAN. DR PIR: A60646; A60646. XX RN [1] RA Boehnlein E., Lowenthal J. W., Siekevitz M., Ballard RA D. W., Franza B. R., Greene W. C. RT The Same Inducible Nuclear Protein Regulates Mitogen RT Activation of Both the Interleukin-2 Receptor-Alpha Gene and Type 1 HIV RL Cell 53:827-836 (1988). RN [2] RA Kunsch C., Ruben S. M., Rosen C. A. RT Selection of optimal kappaB/Rel DNA-binding motifs: RT interaction of both subunits of NF-kappaB with DNA RT is required for transcriptional activation RL Mol. Cell. Biol. 12:4412-4421 (1992). RN [3] RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially RT expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [4] RA Brownell E., Brien S. J., Nash W. G., Rice N. RT Genetic characterization of human c-rel sequences RL Mol. Cell. Biol. 5:2826-2831 (1985). RN [5] RA Ballard D. W., Walker W. H., Doerre S., Sista P., RA Molitor J. A., Dixon E. P., Peffer N. J., Hannink M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding RT protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). RN [6] RA Naumann M., Scheidereit C. RT Activation of NF-6B in vivo is regulated by multiple phosphorylations RL EMBO J. 13:4597-4607 (1994). RN [7] RA Hansen S. K., Nerlov C., Zabel U., Verde P., Johnsen RA M., Baeuerle P., Blasi F. RT A novel complex between the p65 subunit of NF-kappaB RT and c-Rel binds to a DNA element involved in the phorbol RT ester induction of the human urokinase gene RL EMBO J. 11:205-213 (1992). RN [8] RA Sun S.-C., Elwood J., Beraud C., Greene W. C. RT Human T-cell leukemia virus type I Tax activation RT of NF-kappaB/Rel involves phosphorylation and degradation RT of IkappaBalpha and RelA (p65)-mediated induction of the c-rel gene RL Mol. Cell. Biol. 14:7377-7384 (1994). RN [9] RA Richardson P. M., Gilmore T. D. RT vRel is an inactive member of the Rel family of transcriptional RT activating proteins RL J. Virol. 65:3122-3130 (1991). RN [10] RA Sica A., Tan T.-H., Rice N. R., Kretzschmar M., Ghosh P., Young H. A. RT The c-rel protooncogene product c-Rel but not NF-6B RT binds to the intronic region of the human interferon-gamma RT gene at a site related to an interferon-stimulable response gene RL Proc. Natl. Acad. Sci. USA 89:1740-1744 (1992). RN [11] RA Crenon I., Beraud C., Simard P., Montagne J., Veschambre P., Jalinot P. RT The transcriptionally active factors mediating the RT effect of the HTLV-I Tax transactivator on the IL-2Ralpha RT kappaB enhancer include the product of the c-rel proto-oncogene RL Oncogene 8:867-875 (1993). RN [12] RA Kerr L. D., Ransone L. J., Wamsley P., Schmitt M. RA J., Boyer T. G., Zhou Q., Berk A. J., Verma I. M. RT Association between proto-oncoprotein Rel and TATA-binding RT protein mediates transcriptional activation by NF-kappaB RL Nature 365:412-419 (1993). RN [13] RA Doerre S., Sista P., Sun S.-C., Ballard D. W., Greene W. C. RT The c-rel protooncogene product represses NF-kappaB RT p65-mediated transcriptional activation of the long RT terminal repeat of type 1 human immunodeficiency virus RL Proc. Natl. Acad. Sci. USA 90:1023-1027 (1993). RN [14] RA Hansen S. K., Baeuerle P. A., Blasi F. RT Purification, reconstitution, and IkappaB association RT of the c-RelBp65 (RelA) complex, a strong activator of transcription RL Mol. Cell. Biol. 14:2593-2603 (1994). RN [15] RA Franza Jr. B. R., Josephs S. F., Gilman M. Z., Ryan W., Clarkson B. RT Characterization of cellular proteins recognizing RT the HIV enhancer using a microscale DNA-affinity precipitation assay RL Nature 330:391-395 (1987). RN [16] RA Ballard D. W., Walker W. H., Doerre S., Sista P., RA Molitor J. A., Dixon E. P., Peffer N. J., Hannik M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding RT protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). XX // AC T00169 XX ID T00169 XX DT 15.10.92 (created); ewi. DT 05.11.96 (updated); ewi. XX FA c-Rel XX SY HIVEN86A; p68; p82(hc-rel); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0020; Rel; 4.1.1.0.5. XX SZ 587 AA; 65.0 kDa (cDNA), 86 kDa (SDS) XX SQ MASSGYNPYVEIIEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSVQIMNYYGKGK SQ IRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGPERRPLFFQNLGIRCVKKKEVKGAII SQ LRISAGINPFNVGEQQLLDIEDCDLNVVRCVFMFFLPDEDGNFTTALPPIVSNPIYDNRA SQ PNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEARGVFSQADVHRQV SQ AIVFKTPPYCKAILEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDAYGNKSKKQKTTLIF SQ QKLLQDCGHFTEKPRTAPLGSTGEGRFIKKESNLFSHGTVLPEMPRSSGVPGQAEPYYSS SQ CGSISSGLPHHPPAIPSVAHQPTSWPPVTHPTSHPVSTNTLSTFSAGTLSSNSQGILPFL SQ EGPGVSDLSASNSCLYNPDDLARMETPSMSPTDLYSISDVNMLSTRPLSVMAPSTDGMGD SQ TDNPRLVSINLENPSCNARLGPRDLRQLHQMSPASLSAGTSSSSVFVSQSDAFDRSNFSC SQ VDNGLMNEPGLSDDANNPTFVQSSHYSVNTLQSEQLSDPFTYGFFKI XX SC SwissProt #P15307 XX FT 8 295 Rel homology region FT 403 568 trans-activation domain [5]; XX SF c-Rel heterodimers with NF-kappaB1 (p50) prevail in SF mature B cells in contrast to pre-B cells, where p50/RelA SF heterodimers predominate [1]; SF c-Rel/p50 dimers bind 20-fold more stably to the intronic SF kappaB site of the Igkappa gene than p50/RelA dimers [1]; SF the potent C-terminal trans-activation domain is not SF found in v-Rel and is masked in the whole molecule [5]; SF trans-activation requires physical interaction with TBP [7]; XX FF potent acivator [5], [6]; FF early growth response gene [4]; FF may substitute RelA (p65) during B-cell maturation FF thus contributing to the constitutive expression of FF immunoglobulin genes [1]; FF c-rel expression is augmented in mature B cells [1]; XX IN T00169; c-Rel; mouse, Mus musculus. IN T00416; IkappaB-beta; chick, Gallus gallus. IN T00593; NF-kappaB1; human, Homo sapiens. IN T00796; TBP; mouse, Mus musculus. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00971; IkappaB-beta; mouse, Mus musculus. IN T01925; NF-kappaB1 precursor; human, Homo sapiens. XX MX M00053; V$CREL_01 XX BS R00699; HIV1$HIV1_06; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R02173; HIVEN86A$CONS; Quality: 6 BS R01058; MOUSE$M1H2KB_06; Quality: 6; mouse, Mus musculus XX DR EMBL: X15842; MMCRELM(r). DR EMBL: X60271; MMLMREL(r). DR SwissProt: P15307; REL_MOUSE. DR PIR: A45505; A45505. DR PIR: A60367; A60367. XX RN [1] RA Miyamoto S., Schmitt M. J., Verma I. M. RT Qualitative changes in the subunit composition of RT kappa-binding complexes during murine B-cell differentiation RL Proc. Natl. Acad. Sci. USA 91:5056-5060 (1994). RN [2] RA Grumont R. J., Gerondakis S. RT Structure of a mammalian c-rel protein deduced from RT the nucleotide sequence of murine cDNA clones RL Oncogene Res. 4:1-8 (1989). RN [3] RA Grumont R. J., Richardson I. B., Gaff C., Gerondakis S. RT rel/NF-kappa B nuclear complexes that bind kB sites RT in the murine c-rel promoter are required for constitutive RT c-rel transcription in B-cells RL Cell Growth Differ. 4:731-743 (1993). RN [4] RA Bull P., Hunter T., Verma I. M. RT Transcriptional induction of the murine c-rel gene RT with serum and phorbol-12-myristate-13-acetate in fibroblasts RL Mol. Cell. Biol. 9:5239-5243 (1989). RN [5] RA Bull P., Morley K. L., Hoekstra M. F., Hunter T., Verma I. M. RT The mouse c-rel protein has an N-terminal regulatory RT domain and a C-terminal transcriptional transactivation domain RL Mol. Cell. Biol. 10:5473-5485 (1990). RN [6] RA Richardson P. M., Gilmore T. D. RT vRel is an inactive member of the Rel family of transcriptional RT activating proteins RL J. Virol. 65:3122-3130 (1991). RN [7] RA Kerr L. D., Ransone L. J., Wamsley P., Schmitt M. RA J., Boyer T. G., Zhou Q., Berk A. J., Verma I. M. RT Association between proto-oncoprotein Rel and TATA-binding RT protein mediates transcriptional activation by NF-kappaB RL Nature 365:412-419 (1993). RN [8] RA Inoue J.-I., Kerr L. D., Ransone L. J., Bengal E., Hunter T., Verma I. M. RT c-rel activates but v-rel suppresses transcription from kappaB sites RL Proc. Natl. Acad. Sci. USA 88:3715-3719 (1991). XX // AC T00170 XX ID T00170 XX DT 15.10.92 (created); ewi. XX FA CRF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF different from CTF/NF-1 or CBP XX BS R00333; AD$E2L_01; Quality: 6; adenovirus type 2 BS R00335; AD$E2L_03; Quality: 6; adenovirus type 2 BS R00337; AD$E2L_05; Quality: 6; adenovirus type 2 XX RN [1] RA Goding C. R., Temperley S. M., Fisher F. RT Multiple transcription factors interact with the adenovirus-2 RT EII-late promoter: evidence for a new CCAAT recognition factor RL Nucleic Acids Res. 15:7761-7780 (1987). XX // AC T00171 XX ID T00171 XX DT 24.03.93 (created); ewi. DT 04.03.97 (updated); ewi. XX FA C/EBPepsilon XX SY CRP1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.3.0.5. XX SZ 249 AA; 27.2 kDa (gene) XX SQ MCEHEASIDLSAYIESGEEQLLSDLFAMKPTPEARSLKGPGTPSFPHYLPADPRPFAYPS SQ HTFGPDRKALGPGIYSNPGSYDPRAVAVKEEPRGPEGNRGTGRGSYNPLQYQVAHCGQTA SQ VHLPPTLAAPGQPLRVLKAPVAAAAPPCSPLLKAPSPAGPSHKGKKAVNKDSLEYRLRRE SQ RNNIAVRKSRDKAKRRIMETQQKVLEYMAENERLRSRVDQLTQELDTLRNLFRQIPEAAS SQ LIKGVGGCS XX SC translated from EMBL #M85143 XX FT 165 203 basic region FT 207 242 leucine zipper (YL3II) XX IN T00051; ATF; human, Homo sapiens. IN T00108; C/EBPalpha; rat, Rattus norvegicus. IN T00109; C/EBPdelta; rat, Rattus norvegicus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. IN T01303; CREB-2; human, Homo sapiens. IN T02028; C/EBPgamma; rat, Rattus norvegicus. XX BS R00207; AS$CEBP_01; Quality: 6 BS R00097; RAT$ALBU_21; Quality: 6; rat, Rattus norvegicus BS R01358; RAT$SSTA_01; Quality: 6; rat, Rattus norvegicus XX DR EMBL: M85143; RNCRP1A(g). XX RN [1] RA Vinson C. R., Hai T., Boyd S. M. RT Dimerization specificity of the leucine zipper-containing RT bZIP motif on DNA binding: prediction and rational design RL Genes Dev. 7:1047-1058 (1993). RN [2] RA Williams S. C., Cantwell C. A., Johnson P. F. RT A family of C/EBP-related proteins capable of forming RT covalently linked leucine zipper dimers in vitro RL Genes Dev. 5:1553-1567 (1991). XX // AC T00172 XX ID T00172 XX DT 26.01.93 (created); hse. DT 08.03.94 (updated); hwi. XX FA CTCF XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX SZ 130 kDa (SDS) XX CP erythrocytes, muscle, fibroblasts XX BS R02137; CTCF$CONS; Quality: 6 XX DR EMBL: Z22605; GDCTCFPRA(r). XX RN [1] RA Lobanenkov V. V., Nicolas R. H., Adler V. V., Paterson RA H., Klenova E. M., Polotskaja A. V., Goodwin G. H. RT A novel sequence-specific DNA binding protein which RT interacts with three regularly spaced direct repeats RT of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene RL Oncogene 5:1743-1753 (1990). XX // AC T00173 XX ID T00173 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CTF XX OS domestic pig, Sus scrofa OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; artiodactyla; suiformes; suidae XX SQ MGSRLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLG SQ EKAEVKQKWASRLLAKLRKDIRPECREDFVLAITGKKAPGCVLSNPDQKGKMRRIDCLRQ SQ ADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYF SQ VRERGEAGRARGRGSDGREGMRRASQSGRPGESGPAGLRDQAGTRSLGWAG XX SC SwissProt #P14057 XX DR EMBL: X12764; SSNF1A(g). DR SwissProt: P14057; NFIL_PIG. DR PIR: JT0463; JT0463. XX RN [1] RA von der Ahe D., Pearson D., Nakagawa J.-i., Rajput B., Nagamine Y. RT Multiple nuclear factors interact with promoter sequences RT of the urokinase-type plasminogen activator gene RL Nucleic Acids Res. 16:7527 (1988). XX // AC T00174 XX ID T00174 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA CTF XX SY CCAAT-binding factor; NF-1; TGGCA-binding protein (chick); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 52-66 kDa; 62 + 64 kDa (SDS) XX SF glycosylation XX BS R00340; AD$E3_02; Quality: 6; adenovirus type 2 BS R02009; CHICK$BAG_09; Quality: 6; chick, Gallus gallus BS R02631; HIV2$HIV2_01; Quality: 6; HIV-2, human immunodeficiency virus type 2 BS R02634; HIV2$HIV2_04; Quality: 6; HIV-2, human immunodeficiency virus type 2 BS R01752; HS$AAC_09; Quality: 2; human, Homo sapiens BS R00506; HS$AG_01; Quality: 6; human, Homo sapiens BS R00521; HS$BG_02; Quality: 6; human, Homo sapiens BS R00956; HS$CJUN_02; Quality: 6; human, Homo sapiens BS R03038; HS$DPOLA_03; Quality: 6; human, Homo sapiens BS R00761; HS$HSP70_02; Quality: 6; human, Homo sapiens BS R00766; HS$HSP70_07; Quality: 6; human, Homo sapiens BS R00768; HS$HSP70_09; Quality: 6; human, Homo sapiens BS R01455; HS$TF_06; Quality: 6; human, Homo sapiens BS R01443; HSV1$TK_02; Quality: 6; HSV-1, herpes simplex virus type 1 BS R02209; NF1$CONS; Quality: 6 XX DR EMBL: X12492; HSCTF1(r). DR SwissProt: P08651; NFI1_HUMAN. DR SwissProt: P08652; NFI2_HUMAN. DR PIR: S01038; S01038. XX RN [1] RA Angel P., Hattori K., Smeal T., Karin M. RT The jun Proto-Oncogene Is Positively Autoregulated by Its Product, Jun/AP-1 RL Cell 55:875-885 (1988). RN [2] RA Jones K. A., Yamamoto K. R., Tjian R. RT Two distinct transcription factors that bind to the RT HSV thymidine kinase promoter in vitro RL Cell 42:559-572 (1985). RN [3] RA Brunel F., Ochoa A., Schaeffer E., Boissier F., Guillou RA Y., Cereghini S., Cohen G. N., Zakin M. M. RT Interaction of DNA-binding Proteins with the 5' Region RT of the Human Transferrin Gene RL J. Biol. Chem. 263:10180-10185 (1988). RN [4] RA Jones K. A., Kadonaga J. T., Rosenfeld P. J., Kelly T. J., Tjian R. RT A cellular DNA-binding protein that activates eukaryotic RT transcription and replication RL Cell 48:79-89 (1987). RN [5] RA Greene J. M., Larin Z., Taylor I. C. A., Prentice RA H., Gwinn K. A., Kingston R. E. RT Multiple Basal Elements of a Human hsp70 Promoter RT Function Differently in Human and Rodent Cell Lines RL Mol. Cell. Biol. 7:3646-3655 (1987). RN [6] RA Morgan W. D., Williams G. T., Morimoto R. I., Greene RA J., Kingston R. E., Tjian R. RT Two transcriptional activators, CCAAT-box-binding RT transcription factor and heat shock transcription RT factor, interact with a human hsp70 gene promoter RL Mol. Cell. Biol. 7:1129-1138 (1987). RN [7] RA Jackson S. P., Tjian R. RT Purification and analysis of RNA polymerase II transcription RT factors by using wheat germ agglutinin affinity chromatography RL Proc. Natl. Acad. Sci. USA 86:1781-1785 (1989). XX // AC T00175 XX ID T00175 XX DT 25.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CTF-1 XX SY NF-1; XX OS domestic pig, Sus scrofa OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; artiodactyla; suiformes; suidae XX CL ; ; 1.4.1.0.3.1. XX SZ 506 AA; 55.5 kDa (cDNA) XX SQ MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDE SQ LLGEKAEVKQKWASRLLAKLRKDIRPECREDFVLAITGKKAPGCVLSNPDQKGKMRRIDC SQ LRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYL SQ AYFVRERDAEQSGSPRAGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVV SQ TGTGPNFSLGELQGHMAYDLNPASTGMRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYY SQ TSPSSPTSSNRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVH SQ SGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQ SQ PGPLNGSGQLKMSSHCLSAQMLAPPPPGLPRLALPPATKPTSEGGSSSPTSPSYSTPGTS SQ PANRSFVGLGPRDPTGIYQAQSWYLG XX SC SwissProt #P21999 XX SF proline-rich region SF lysine helix XX BS R02209; NF1$CONS; Quality: 6 XX DR EMBL: X12764; SSNF1A(g). DR EMBL: J02875; SSNFICTF(g). DR SwissProt: P21999; NFIM_PIG. DR PIR: A33416; A33416. XX RN [1] RA Altman H., Wendler W., Winnacker E. L. RT Transcriptional activation by CTF proteins is mediated RT by a bipartite low-proline domain RL Proc. Natl. Acad. Sci. USA 91:3901-3905 (1994). RN [2] RA Meisterernst M., Rogge L., Foeckler R., Karaghiosoff M., Winnacker E.-L. RT Structural and functional organization of a porcine RT gene coding for nuclear factor I RL Biochemistry 28:8191-8200 (1989). XX // AC T00176 XX ID T00176 XX DT 15.10.92 (created); ewi. DT 15.08.96 (updated); ewi. XX FA CTF-1 XX SY NF-1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 1.4.1.0.3.1. XX SZ 499 AA; 54.7 kDa (cDNA) XX SQ MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVK SQ QKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWR SQ LDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA SQ EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSL SQ GELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSS SQ SRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHP SQ SSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQ SQ LKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFV SQ GLGPRDPAGIYQAQSWYLG XX SC SwissProt #P08651 XX FT 1 220 DNA-binding, dimerization and replication FT stimulating domain [9]; FT 68 151 region containing some residues exclusively FT important for replication functions [5]; FT 179 202 encoded by alternative exon 3, absent in CTF-3 FT 388 487 proline-rich (23/100) trans-activating region [10]; FT 415 499 CTF-1 specific region FT 460 479 most important part of the trans-activating region [4]; FT 461 469 polII CTD-homologous SPTSPSYSP peptide FT 463 508 proline-rich trans-activating region XX SF at least 7 splice variants are encoded by the CTF SF gene: three Cys residues are essential for DNA-binding SF (Cys-95, -148, -154) [3]; SF the trans-activating domain is encoded by exons 7-9 SF the expression of which differs in all splice variants [7]; SF interaction with co-activators is required for trans-activation [2]; SF direct interaction with TFIIB facilitates recruitment SF of TFIIB to the preinitiation complex [8]; XX CP widespread CN B cells, T cells [1]; XX FF activator [10]; FF stimulator of (adenoviral) DNA replication [10]; FF facilitating assembly of basal transcription complex [2]; FF competing with histones, esp. with H5 [2]; XX IN T00176; CTF-1; human, Homo sapiens. IN T00818; TFIIB; human, Homo sapiens. XX BS R01175; AD$ORI_01; Quality: 6; adenovirus type 2 BS R00506; HS$AG_01; Quality: 6; human, Homo sapiens BS R01311; HS$RAS1_07; Quality: 6; human, Homo sapiens BS R02209; NF1$CONS; Quality: 6 XX DR EMBL: X12492; HSCTF1(r). DR SwissProt: P08651; NFI1_HUMAN. DR PIR: S01038; S01038. XX RN [1] RA McQuillan J. J., Rosen G. D., Birkenmeier T. M., Dean D. C. RT Identification of a protein that interacts with the RT nuclear factor-1 ( NF-1 ) binding site in cells that RT do not express NF-1: comparison to NF-1, cellular RT distribution, and effect on transcription RL Nucleic Acids Res. 19:6627-6631 (1991). RN [2] RA Dusserre Y., Mermod N. RT Purified cofactors and histone H1 mediate transcriptional RT regulation by CTF/NF-I RL Mol. Cell. Biol. 12:5228-5237 (1992). RN [3] RA Novak A., Goyal N., Gronostajski R. M. RT Four conserved cysteine residues are required for RT the DNA binding activity of nuclear factor I RL J. Biol. Chem. 267:12986-12990 (1992). RN [4] RA Kim T. K., Roeder R. G. RT CTD-like sequences are important for transcriptional RT activation by the proline-rich activation domain of CTF1 RL Nucleic Acids Res. 22:251-251 (1994). RN [5] RA Armentero M. T., Horwitz M., Mermod N. RT Targeting of DNA polymerase to the adenovirus prigin RT of DNA replication by interaction with nuclear factor I RL Proc. Natl. Acad. Sci. USA 91:11537-11541 (1994). RN [6] RA Wendler W., Altmann H., Winnacker E. L. RT Transcriptional activation of NF1/CTF1 depends on RT a sequence motif strongly related to the carboxyterminal RT domain of RNA polymerase II RL Nucleic Acids Res. 22:2601-2603 (1994). RN [7] RA Altman H., Wendler W., Winnacker E. L. RT Transcriptional activation by CTF proteins is mediated RT by a bipartite low-proline domain RL Proc. Natl. Acad. Sci. USA 91:3901-3905 (1994). RN [8] RA Kim T. K., Roeder R. G. RT Proline-rich activator CTF1 targets the TFIIB assembly RT step during transcriptional activation RL Proc. Natl. Acad. Sci. USA 91:4170-4174 (1994). RN [9] RA Mermod N., O'Neill E. A., Kelly T. J., Tjian R. RT The Proline-Rich Transcriptional Activator of CTF/NF-I RT Is Distinct from the Replication and DNA Binding Domain RL Cell 58:741-753 (1989). RN [10] RA Santoro C., Mermod N., Andrews P. C., Tjian R. RT A family of human CCAAT-box-binding proteins active RT in transcription and DNA replication: cloning and RT expression of multiple cDNAs RL Nature 334:218-224 (1988). XX // AC T00177 XX ID T00177 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CTF-2 XX SY NF-1C2 (chick); NFI-C2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 1.4.1.0.3.2. XX SZ 430 AA; 47.9 kDa (cDNA) XX SQ MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVK SQ QKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWR SQ LDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA SQ EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSL SQ GELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSS SQ SRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHP SQ SSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPPTLRPT SQ RPLQTVPLWD XX SC SwissProt #P08652 XX FT 1 220 DNA-binding and dimerization domain FT 179 202 encoded by alternative exon 3, absent in CTF-3 FT 388 427 proline-rich region FT 415 430 CTTF-2/3 specific region XX BS R00506; HS$AG_01; Quality: 6; human, Homo sapiens BS R01311; HS$RAS1_07; Quality: 6; human, Homo sapiens BS R02209; NF1$CONS; Quality: 6 XX DR EMBL: X12492; HSCTF1(r). DR SwissProt: P08652; NFI2_HUMAN. XX RN [1] RA Santoro C., Mermod N., Andrews P. C., Tjian R. RT A family of human CCAAT-box-binding proteins active RT in transcription and DNA replication: cloning and RT expression of multiple cDNAs RL Nature 334:218-224 (1988). XX // AC T00178 XX ID T00178 XX DT 15.10.92 (created); ewi. DT 22.08.96 (updated); ewi. XX FA CTF-3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 1.4.1.0.3.3. XX SZ 406 AA; 45.4 kDa (cDNA) XX SQ MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVK SQ QKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWR SQ LDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDT SQ TDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPS SQ TSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKS SQ PFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTA SQ IRYPPHLNPQDPLKDLVSLACDPASQQPGPPTLRPTRPLQTVPLWD XX SC SwissProt #P08652 and edited XX FT 1 220 DNA-binding and dimerization domain FT 364 403 proline-rich region FT 391 406 CTF-2/3 specific region XX BS R00506; HS$AG_01; Quality: 6; human, Homo sapiens BS R01311; HS$RAS1_07; Quality: 6; human, Homo sapiens XX DR EMBL: X12492; HSCTF1(r). DR SwissProt: P08652; NFI2_HUMAN. XX RN [1] RA Mermod N., O'Neill E. A., Kelly T. J., Tjian R. RT The Proline-Rich Transcriptional Activator of CTF/NF-I RT Is Distinct from the Replication and DNA Binding Domain RL Cell 58:741-753 (1989). RN [2] RA Santoro C., Mermod N., Andrews P. C., Tjian R. RT A family of human CCAAT-box-binding proteins active RT in transcription and DNA replication: cloning and RT expression of multiple cDNAs RL Nature 334:218-224 (1988). XX // AC T00179 XX ID T00179 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CUP2 XX SY ACE1; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 0.1.1.0.1. XX SZ 225 AA; 24 kDa (SDS) XX SQ MVVINGVKYACETCIRGHRAAQCTHTDGPLQMIRRKGRPSTTCGHCKELRRTKNFNPSGG SQ CMCASARRPAVGSKEDETRCRCDEGEPCKCHTKRKSSRKSKGGSCHRRANDEAAHVNGLG SQ IADLDVLLGLNGRSSDVDMTTTLPSLKPPLQNGEIKADSIDNLDLASLDPLEQSPSISME SQ PVSINETGSAYTTTNTALNDIDIPFSINELNELYKQVSSHNSHSQ XX SC SwissProt #P15315 XX SF (no zinc finger) XX FF copper-dependent activator of metallothionein gene (CUP1) XX BS R01040; Y$CUP1_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01041; Y$CUP1_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R01042; Y$CUP1_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R01043; Y$CUP1_04; Quality: 5; yeast, Saccharomyces cerevisiae BS R01845; Y$CUP1_05; Quality: 2; yeast, Saccharomyces cerevisiae BS R01846; Y$CUP1_06; Quality: 4; yeast, Saccharomyces cerevisiae BS R03493; Y$SOD1_01; Quality: 4; yeast, Saccharomyces cerevisiae XX DR EMBL: M24390; SCACE1A(g). DR EMBL: M22580; SCACEA(g). DR SwissProt: P15315; ACE1_YEAST. DR PIR: A30133; A30133. DR PIR: A31926; A31926. XX RN [1] RA Fuerst P., Hu S., Hackett R., Hamer D. RT Copper activates metallothionein gene transcription RT by altering the conformation of a specific DNA binding protein RL Cell 55:705-717 (1988). RN [2] RA Huibregtse J. M., Engelke D. R., Thiele D. J. RT Copper-induced binding of cellular factors to yeast RT methallothionein upstream activating sequences RL Proc. Natl. Acad. Sci. USA 86:65-69 (1989). RN [3] RA Welch J., Fogel S., Buchman C., Karin M. RT The CUP2 gene product regulates the expression of RT the CUP1 gene, coding for yeast metallothionein RL EMBO J. 8:255-260 (1989). RN [4] RA Buchman C., Skroch P., Welch J., Fogel S., Karin M. RT The CUP2 Gene Product, Regulator of Yeast Metallothionein RT Expression, Is a Copper-Activated DNA-Binding Protein RL Mol. Cell. Biol. 9:4091-4095 (1989). RN [5] RA Fuerst P., Hamer D. RT Cooperative activation of a eukaryotic transcription RT factor: Interaction between Cu(I) and yeast ACE1 protein RL Proc. Natl. Acad. Sci. USA 86:5267-5271 (1989). RN [6] RA Evans C. F., Engelke D. R., Thiele D. J. RT ACE1 Transcription Factor Produced in Escherichia RT coli Binds Multiple Regions within Yeast Metallothionein RT Upstream Activation Sequences RL Mol. Cell. Biol. 10:426-429 (1990). RN [7] RA Buchman C., Skroch P., Dixon W., Tullius Th. D., Karin M. RT A single amino acid change in CUP2 alters its mode of DNA binding RL Mol. Cell. Biol. 10:4778-4787 (1990). XX // AC T00180 XX ID T00180 XX DT 16.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA CYS3 XX SY cys-3; XX OS Neurospora crassa OC eukaryota; plantae; thallobionta; eumycota; ascomycotina; OC pyrenomycetes; sordariales; sordariaceae XX CL C0008; bZIP; 1.1.1.0.2. XX SZ 236 AA XX SQ MSSADFNFGDFTTTYTSPTIPAYPDTLGQLQPIQPNPQAAYPPVSQHHASHHVQHPHQPG SQ YVLSNPPQLSGNKRKASDAMSVPPTPGARVMSFEEASRLAAEEDKRKRNTAASARFRIKK SQ KQREQALEKSAKEMSEKVTQLEGRIQALETENKWLKGLVTEKHGSKEDILKLLREFSAHA SQ AKVSKDAAAAAADKAEAAADKADAERAREESSFCVSTSSPSSDESVDTDNKKRRKD XX SC SwissProt #P22697 XX SF LML3 XX FF activator; FF product of the master sulfur regulatory gene XX BS R02344; NEUCR$CYS14_01; Quality: 2; Neurospora crassa BS R02345; NEUCR$CYS14_02; Quality: 2; Neurospora crassa BS R02346; NEUCR$CYS14_03; Quality: 2; Neurospora crassa BS R02347; NEUCR$CYS3_01; Quality: 2; Neurospora crassa XX DR EMBL: M26008; NCCYS3(g). DR SwissProt: P22697; CYS3_NEUCR. DR PIR: A30225; A30225. XX RN [1] RA Kanaan M. N., Marzluf G. A. RT Mutational analysis of the DNA-binding domain of CYS3 RT regulatory protein of Neurospora crassa RL Mol. Cell. Biol. 11:4356-4362 (1991). RN [2] RA Fu Y.-H., Paietta J. V., Mannix D. G., Marzluf G. A. RT cys-3, the positive-acting sulfur regulatory gene RT of Neurospora crassa, encodes a sequence-specific DNA-binding protein RL Mol. Cell. Biol. 9:1120-1127 (1989). RN [3] RA Marzluf G. A., Metzenberg R. L. RT Positive control by the CYS-3 locus in regulation RT of sulfur metabolism in Neurospora RL J. Mol. Biol. 33:423-437 (1968). RN [4] RA Paietta J. V., Akins R. A., Lambowitz A. M., Marzluf G. A. RT Molecular cloning and characterization of the cys-3 RT regulatory gene of Neurospora crassa RL Mol. Cell. Biol. 7:2506-2511 (1987). RN [5] RA Fu Y.-H., Marzluf G. A. RT cys-3, the positive-acting sulfur regulatory gene RT of Neurospora crassa, encodes a sequence-specific DNA-binding protein RL J. Biol. Chem. 265:11942-11947 (1990). XX // AC T00181 XX ID T00181 XX DT 15.10.92 (created); ewi. XX FA DAP XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R01627; SV$MLP_01; Quality: 6; SV40, simian virus 40 XX RN [1] RA Ayer D. E., Dynan W. S. RT A Downstream-Element-Binding Factor Facilitates Assembly RT of a Functional Preinitiation Complex at the Simian RT virus 40 Major Late Promoter RL Mol. Cell. Biol. 10:3635-3645 (1990). XX // AC T00182 XX ID T00182 XX DT 16.04.93 (created); ewi. XX FA DBF4 XX SY TFIIDtau-binding factor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF TBP cofactor, competes with TFIIA for binding to TBP XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX BS R00705; HIV1$HIV1_12; Quality: 6; HIV-1, human immunodeficiency virus type 1 XX RN [1] RA Meisterernst M., Roeder R. G. RT Family of proteins that interact with TFIID and regulate promoter activity RL Cell 67:557-567 (1991). XX // AC T00183 XX ID T00183 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA DBP XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO VBP XX CL C0008; bZIP; 1.1.4.0.1. XX SZ 325 AA; 34.4 kDa (cDNA); 43 kDa, 46 kDa (SDS) XX SQ MARPLSDRTPGPLLLGGPAGAPPGGGALLGLRSLLQGNSKPKEPASCLLKEKERKATLPS SQ APVPGPVLETAGPADAPTGAVSGGGSPRGRSGPVAGPSLFAPLLWERTLPFGDVEYVDLD SQ AFLLEHGLPPSPPPPGGLSPAPSPARTPAPSPGPGSCSSSSPRSSPGHAPARATLGAAGG SQ HRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPI SQ MKKARKVQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQE SQ VVAVRQELSHYRAVLSRYQAQHGTL XX SC SwissProt #P16443 XX FT 188 239 PAR region FT 258 277 basic region FT 283 304 variant leucine zipper (ILLV) XX SF no heterodimerization with ATF-4 or C/EBPgamma [3]; XX CP liver-enriched; mRNA: liver, brain, spleen, thymus, CP lung, kidney, heart, salivary gland; low level: testis XX FF transcriptional activator in hepatic cells [2], [5]; FF member of the C/EBP-family; FF up to 1000-fold accumulation according to circadian FF rhythm: barely detectable in the morning, level increases FF early afternoon, maximum at 8 p.m., sharp decline during the night [7], [4]; FF DBP protein is not yet seen in 1 week old rats, but FF by 5-25 weeks of age [6]; XX IN T00183; DBP; rat, Rattus norvegicus. IN T01071; Hlf; human, Homo sapiens. IN T01072; TEF; rat, Rattus norvegicus. XX BS R00207; AS$CEBP_01; Quality: 6 BS R02138; DBP$CONS_01; Quality: 1 BS R04248; DBP$CONS_02; Quality: 6 BS R03251; HS$ADH1_07; Quality: 1; human, Homo sapiens BS R03128; HS$ADH2_03; Quality: 2; human, Homo sapiens BS R03243; HS$ADH3_09; Quality: 2; human, Homo sapiens BS R00089; MOUSE$ALBU_08; Quality: 6; mouse, Mus musculus BS R04270; RAT$CYP2C6_01; Quality: 2; rat, Rattus rattus BS R00616; RAT$GRH_10; Quality: 6; rat, Rattus norvegicus BS R02987; RAT$PFK_03; Quality: 6; rat, Rattus norvegicus XX DR EMBL: J03179; RNDBPA(r). DR SwissProt: P16443; DBP_RAT. DR PIR: A38894; A38894. DR PIR: A39531; A39531. XX RN [1] RA Hunger S. P., Ohyashiki K., Toyama K., Cleary M. L. RT Hlf, a novel hepatic bZIP protein, shows altered DNA-binding RT properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia RL Genes Dev. 6:1608-1620 (1992). RN [2] RA Mueller C. R., Maire P., Schibler U. RT DBP, a liver-enriched transcriptional activator, is RT expressed late in ontogeny and its tissue specificity RT is determined posttranscriptionally RL Cell 61:279-291 (1990). RN [3] RA Vinson C. R., Hai T., Boyd S. M. RT Dimerization specificity of the leucine zipper-containing RT bZIP motif on DNA binding: prediction and rational design RL Genes Dev. 7:1047-1058 (1993). RN [4] RA Wuarin J., Falvey E., Lavery D., Talbot D., Schmidt RA E., Ossipow V., Fonjallaz P., Schibler U. RT The role of the transcriptional activator protein RT DBP in circadian liver gene expression RL J. Cell Science 16:123-127 (1992). RN [5] RA Lavery D. L., Schibler U. RT DBP and related transcription factors of the PAR family RL Liver Gene Expression, F. Tronche and M. Yaniv (eds.), R. G. Landes Comp., Austin 1994 0:259-275 (1994). RN [6] RA Yano M., Falvey E., Gonzalez F. J. RT Role of the liver-enriched transcription factor DBP RT in expression of the cytochrome P450 CYP2C6 gene RL Mol. Cell. Biol. 12:2847-2854 (1992). RN [7] RA Wuarin J., Schibler U. RT Expression of the liver-enriched transcriptional activator RT protein DBP follows a stringent circadian rhythm RL Cell 63:1257-1266 (1990). XX // AC T00184 XX ID T00184 XX DT 15.10.92 (created); ewi. XX FA DBP XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX IN T01071; Hlf; human, Homo sapiens. IN T01072; TEF; rat, Rattus norvegicus. XX BS R01175; AD$ORI_01; Quality: 6; adenovirus type 2 BS R02459; HS$ALBU_06; Quality: 6; human, Homo sapiens BS R00089; MOUSE$ALBU_08; Quality: 6; mouse, Mus musculus BS R02457; MOUSE$SAA3_01; Quality: 6; mouse, Mus musculus BS R02458; MOUSE$SAA3_02; Quality: 6; mouse, Mus musculus XX RN [1] RA Cleat P. H., Hay R. T. RT Co-operative interactions between NFI and the adenovirus RT DNA binding protein at the adenovirus origin of replication RL EMBO J. 8:1841-1848 (1989). XX // AC T00185 XX ID T00185 XX DT 26.01.93 (created); ewi. DT 22.08.96 (updated); ewi. XX FA DbpA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0019; protamine-like; 1.8.1.0.1. XX SZ 342 AA; 37.0 kDa (cDNA) XX SQ MSEAGEATTTTTTTLPQAPTEAAAAAPQDPAPKSPVGSGAPQAAAPAPAAHVAGNPGGDA SQ APAATGTAAAASLAAAAGSEDAEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQ SQ TAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRG SQ YYGRRRGPPRNYAGEEEEEGSGSSEGFDPPATDRQFSGARNQLRRPQYRPQYRQRRFPPY SQ HVGQTFDRRSRVLPHPNRIQAGEIGEMKDGVPEGAQLQGPVHRNPTYRPRYRSRGPPRPR SQ PAPAVGEAEDKENQQATSGPNQPSVRRGYRRPYNYRRRPPSS XX SC SwissProt #P16989 XX FT 84 158 cold shock domain FT 192 260 not present in a potential splice variant FT 8 20 threonine-rich region (8/13) FT 18 77 alanine-rich region (27/60) FT 195 208 acidic region (7/14) FT 280 340 proline-rich region (13/61) XX DR EMBL: M24069; HSDBPA(r). DR SwissProt: P16989; DBPA_HUMAN. DR PIR: PS0014; PS0014. XX RN [1] RA Wolffe A. P., Tafuri S. R., Ranjan M., Familari M. RT The Y-box factors: a family of nucleic acid binding RT protein conserved from Escherichia coli to man RL New Biologist 4:250-298 (1992). RN [2] RA Sakura H., Maekawa T., Imamoto F., Yusuda K., Ishii S. RT Two human genes isolated by a novel method encode RT DNA-binding proteins containing a common region of homology RL Gene 73:499-507 (1988). XX // AC T00186 XX ID T00186 XX DT 26.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA DbpB XX SY EFIA (rat, chick); YB-1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0019; protamine-like; 1.8.1.0.2. XX SZ 324 AA; 35.4 kDa (cDNA) XX SQ MSSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVL SQ GTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGA SQ EAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEG SQ QAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRG SQ YRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDG SQ KETKAADPPAENSSAPEAEQGGAE XX SC SwissProt #P16990 XX FT 52 128 cold shock domain XX SF identical to YB-1 except Ala-120 (Glu in YB-1) and SF divergent C-terminal 11 AA XX DR EMBL: M24070; HSDBPB(r). DR SwissProt: P16990; CBFX_HUMAN. DR PIR: PS0015; PS0015. XX RN [1] RA Sakura H., Maekawa T., Imamoto F., Yusuda K., Ishii S. RT Two human genes isolated by a novel method encode RT DNA-binding proteins containing a common region of homology RL Gene 73:499-507 (1988). XX // AC T00187 XX ID T00187 XX DT 12.03.93 (created); ewi. XX FA DENF1 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CP (embryos) XX BS R03030; DROME$EVE_35; Quality: 6; fruit fly, Drosophila melanogaster XX DR Flybase: FBgn0000606; eve. XX RN [1] RA Jiang J., Hoey T., Levine M. RT Autoregulation of a segmentation gene in Drosophila: RT combinatorial interaction of the even-skipped homeo RT box protein with a distal enhancer element RL Genes Dev. 5:265-277 (1991). XX // AC T00188 XX ID T00188 XX DT 12.03.93 (created); ewi. XX FA DENF2 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CP (embryos) XX BS R03032; DROME$EVE_37; Quality: 6; fruit fly, Drosophila melanogaster XX DR Flybase: FBgn0000606; eve. XX RN [1] RA Jiang J., Hoey T., Levine M. RT Autoregulation of a segmentation gene in Drosophila: RT combinatorial interaction of the even-skipped homeo RT box protein with a distal enhancer element RL Genes Dev. 5:265-277 (1991). XX // AC T00189 XX ID T00189 XX DT 12.03.93 (created); ewi. XX FA DENF3 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CP (embryos) XX BS R03033; DROME$EVE_38; Quality: 6; fruit fly, Drosophila melanogaster XX DR Flybase: FBgn0000606; eve. XX RN [1] RA Jiang J., Hoey T., Levine M. RT Autoregulation of a segmentation gene in Drosophila: RT combinatorial interaction of the even-skipped homeo RT box protein with a distal enhancer element RL Genes Dev. 5:265-277 (1991). XX // AC T00190 XX ID T00190 XX DT 15.10.92 (created); ewi. XX FA DF-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R01003; AD$MLP_18; Quality: 6; adenovirus XX RN [1] RA Carcamo J., Lobos S., Merino A., Buckbinder L., Weinmann RA R., Natarajan V., Reinberg D. RT Factors Involved in Specific Transcription by Mammalian RNA Polymerase II RL J. Biol. Chem. 264:7704-7714 (1989). XX // AC T00191 XX ID T00191 XX DT 15.10.92 (created); ewi. XX FA DF-2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R01006; AD$MLP_21; Quality: 6; adenovirus XX RN [1] RA Carcamo J., Lobos S., Merino A., Buckbinder L., Weinmann RA R., Natarajan V., Reinberg D. RT Factors Involved in Specific Transcription by Mammalian RNA Polymerase II RL J. Biol. Chem. 264:7704-7714 (1989). XX // AC T00192 XX ID T00192 XX DT 15.10.92 (created); ewi. XX FA DF-3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R01009; AD$MLP_24; Quality: 6; adenovirus XX RN [1] RA Carcamo J., Lobos S., Merino A., Buckbinder L., Weinmann RA R., Natarajan V., Reinberg D. RT Factors Involved in Specific Transcription by Mammalian RNA Polymerase II RL J. Biol. Chem. 264:7704-7714 (1989). XX // AC T00193 XX ID T00193 XX DT 30.11.92 (created); ewi. DT 16.12.96 (updated); ewi. XX FA Dfd XX SY Deformed; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0006; homeo; 3.1.1.2.4. XX SZ 590 AA; 63.8 kDa (cDNA) XX SQ MSSFLMGYPHAPHHVQSPMSMGNGLDPKFPPVADDYHHYNGHYSMTASTGHMSGAVGGGA SQ GVGSVGGGGAGGMTGHPHSMHPADMVSDYMAHHHNPHSHSHSHTHSLPHHHSNSAISGHH SQ QASAGGYSSNYANATPPSHPHSHPHAHPHQSLGYYVHHAPEFISAGAVHSDPTNGYGPAA SQ NVPNTSNGGGGGGSGAVLGGGAVGGSANGYYGGYGGGYGTANGSVGSTHSQGHSPHSQMM SQ DLPLQCSSTEPPTNTALGLQELGLKLEKRIEEAVPAGQQLQELGMRLRCDDMGSENDDMS SQ EEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSY SQ QPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMK SQ WKKDNKLPNTKNVRKKTVDANGNPTPVAKKPTKRAASKKQQQAQQQQQSQQQQTQQTQQT SQ PVMNECIRSDSLESIGDVSSSLGNPPYIPAAPETTSSYPGSQQHLSNNNNNGSGNNNNNN SQ NNNNNSNLNNNNNNNQMGHTNLHGHLQQQQSDLMTNLQLHIKQDYDLTAL XX SC SwissProt #P07548 XX FT 343 348 Antp-type hexapeptide FT 366 425 homeo domain XX SF the N-terminal arm in front of homeo domain helix SF 1 is responsible for discrimination of DNA-binding against Ubx [8], [9]; XX CP parasegments 0, 1, psart of 2 [3], [5]; XX FF homeotic selector gene product; FF Dfd-expressing cells induce neighbouring cells to FF differentiate to cirri across parasegment borders [6]; FF also induces formation of other maxillary segment FF structures like mouth hooks [6]; FF dfd expression is repressed by several other homeotic FF genes (Scr, Antp, Ubx, Abd-B), but is subject to positive FF autoregulation [6]; FF target of segment polarity genes wingless and engrailed (T00253) [6]; XX MX M00019; I$DFD_01 XX BS R02481; DFD$CONS; Quality: 6 BS R03025; DROME$DFD_01; Quality: 1; fruit fly, Drosophila melanogaster BS R03026; DROME$DFD_02; Quality: 1; fruit fly, Drosophila melanogaster BS R03027; DROME$DFD_03; Quality: 1; fruit fly, Drosophila melanogaster BS R03028; DROME$DFD_04; Quality: 1; fruit fly, Drosophila melanogaster XX DR EMBL: M13373; DMANTDFD(r). DR EMBL: X05136; DMDFD(r). DR SwissProt: P07548; HMDF_DROME. DR PIR: A24780; A24780. DR PIR: A27738; A27738. DR Flybase: FBgn0000439; Dfd. XX RN [1] RA Ekker S. C., Jackson D. G., von Kessler D. P., Sun RA B. I., Young K. E., Beachy P. A. RT The degree of variation in DNA sequence recognition RT among four Drosophila homeotic proteins RL EMBO J. 13:3551-3560 (1994). RN [2] RA Regulski M., Harding K., Kostriken R., Karch F., Levine M., McGinnis W. J. RT Homeo box genes of the antennapedia and bithorax complexes of Drosophila RL Cell 43:71-80 (1985). RN [3] RA Regulski M., McGinnis N., Chadwick R., McGinnis W. RT Developmental and molecu-lar analysis of Deformed; RT a homeotic gene controlling Drosophila head development RL EMBO J. 6:767-777 (1987). RN [4] RA Laughon A., Carroll S. B., Storfer F. A., Riley P. D., Scott M. P. RT Common properties of proteins encoded by the antennapedia RT complex genes of Drosophila melanogaster RL Cold Spring Harbor Symp. Quant. Biol. 50:253-262 (1985). RN [5] RA Chadwick R., McGinnis W. RT Temporal and spatial distribution of transcripts from RT the Deformed gene of Drosophila RL EMBO J. 6:779-789 (1987). RN [6] RA Gonzalez-Reyes A., MacRas A., Morata G. RT Autocatalysis and phenotypic expression of Drosophila RT homeotic gene Deformed: its dependence on polarity RT and homeotic gene function RL Development 116:1059-1068 (1992). RN [7] RA Regulski M., Dessain S., McGinnis N., McGinnis W. RT High-affinity binding sites for the deformed protein RT are required for the function of an autoregulatory RT enhancer of the Deformed gene RL Genes Dev. 5:278-286 (1991). RN [8] RA Ekker S. C., von Kessler D. P., Beachy Ph. A. RT Differential DNA sequence recognition is a determinant RT of specificity in homeotic gene action RL EMBO J. 11:4059-4072 (1992). RN [9] RA Lin L., McGinnis W. RT Mapping functional specificity in the Dfd and Ubx homeo domains RL Genes Dev. 6:1071-1081 (1992). XX // AC T00194 XX ID T00194 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA dioxin receptor XX SY Ah receptor; XRE-binding factor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 1.2.6.0.1. XX SZ 100 kDa (6S form) XX SQ MSSGANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVI SQ NKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRNGGQDQCRAQIRDWQDLQEGEFLLQAL SQ NGFVLVVTADAFLFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRHVHWALNPDS SQ AQGVDEAHGPPQAAVYYTPDQLPPENASFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYL SQ HGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQL SQ ILGYTEVELCTRGSGYQFIHAADILHCAESHIRMIKTGESGMTVFRLLAKHSRWRWVQSN SQ ARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSTSLPFMFATGEAVLYEISSPFSPIMDP SQ LPIRTKSNTSRKDWAPQSTPSKDSFHPSSLMSALIQQDESIYLCPPSSPALLDSHFLMGS SQ VSKCGSWQDSFAAAGSEAALKHEQIGHAQDVNLALSGGPSELFPDNKNNDLYSIMRNLGI SQ DFEDIRSMQNEEFFRTDSTAAGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVTQ SQ HLSCMLQERLQLEQQQQLQQPPPQALEPQQQLCQMVCPQQDLGPKHTQINGTFASWNPTP SQ PVSFNCPQQELKHYQLFSSLQGTAQEFPYKPEVDSVPYTQNFAPCNQPLLPEHSKSVQLD SQ FPGRDFEPSLHPTTSNLDFVSCLQVPENQSHGINSQSAMVSPQAYYAGAMSMYQCQPGPQ SQ RTPVDQTQYSSEIPGSQAFLSKVQS XX SC SwissProt #P30561 XX SF detectable as 6S and 9S form XX FF DNA-binding can be abolished by phosphatase treatment XX IN T00992; Hsp90; human, Homo sapiens. XX MX M00139; V$AHR_01 XX BS R00267; RAT$CYTOP_01; Quality: 6; rat, Rattus norvegicus BS R00268; RAT$CYTOP_02; Quality: 6; rat, Rattus norvegicus BS R00270; RAT$CYTOP_04; Quality: 6; rat, Rattus norvegicus XX DR EMBL: M94623; MMB1AHR(r). DR SwissProt: P30561; AHR_MOUSE. DR PIR: JQ1485; JQ1485. XX RN [1] RA Pongratz I., Stroemstedt P.-E., Mason G. G. F., Poellinger L. RT Inhibition of the specific DNA binding activity of RT the dioxin receptor by phosphatase treatment RL J. Biol. Chem. 266:16813-16817 (1991). RN [2] RA Fujisawa-Sehara A., Yamane M., Fuji-Kuriyama Y. RT A DNA-binding factor specific for xenobiotic responsive RT elements of P-450c gene exists as a cryptic form in RT cytoplasm: Its possible translocation to nucleus RL Proc. Natl. Acad. Sci. USA 85:5859-5863 (1988). RN [3] RA Denison M. S., Fisher J. M., Whitlock jr. J. P. RT Inducible, receptor-dependent protein-DNA interactions RT at a dioxin-responsive transcriptional activator RL Proc. Natl. Acad. Sci. USA 85:2528-2532 (1988). RN [4] RA Hapgood J., Cuthill S., Denis M., Poellinger L., Gustafsson J.-A. RT Specific protein-DNA interactions at a xenobiotic-responsive RT element: Copurification of dioxin receptor and DNA-binding affinity RL Proc. Natl. Acad. Sci. USA 86:60-64 (1989). RN [5] RA Neuhold L. A., Shirayoshi Y., Ozato K., Jones J. E., Nebert D. W. RT Regulation of Mouse CYP1A1 Gene Expression by Dioxin: RT Requirement of Two cis-Acting Elements during Induction RL Mol. Cell. Biol. 9:2378-2386 (1989). RN [6] RA Wilhelmsson A., Cuthill S., Denis M., Wikstroem A.-C., RA Gustafsson J. A., Poellinger L. RT The specific DNA binding activity of the dioxin receptor RT is modulated by the 90 kd heat shock protein RL EMBO J. 9:69-76 (1990). RN [7] RA Denison M. S., Fisher J. M., Whitlock J. P. RT Protein-DNA Interactions at Recognition Sites for RT the Dioxin-Ah Receptor Complex RL J. Biol. Chem. 264:16478-16482 (1989). XX // AC T00195 XX ID T00195 XX DT 15.10.92 (created); ewi. DT 12.03.93 (updated); ewi. XX FA dioxin receptor XX SY Ah receptor; XRE-binding factor; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 1.2.6.0.1. XX SZ 150-200 kDa (native); 100+150 kDa (SDS) XX CP (liver) XX FF induced by TCDD and other aromatic hydrocarbons XX MX M00139; V$AHR_01 XX BS R00270; RAT$CYTOP_04; Quality: 6; rat, Rattus norvegicus XX DR Compel: C00089 XX RN [1] RA Denison M. S., Fisher J. M., Whitlock jr. J. P. RT Inducible, receptor-dependent protein-DNA interactions RT at a dioxin-responsive transcriptional activator RL Proc. Natl. Acad. Sci. USA 85:2528-2532 (1988). RN [2] RA Hapgood J., Cuthill S., Denis M., Poellinger L., Gustafsson J.-A. RT Specific protein-DNA interactions at a xenobiotic-responsive RT element: Copurification of dioxin receptor and DNA-binding affinity RL Proc. Natl. Acad. Sci. USA 86:60-64 (1989). RN [3] RA Nemoto T., Mason G. F., Wilhelmsson A., Cuthill S., RA Hapgood J., Gustafsson J. A., Poellinger L. RT Activation of the Dioxin and Glucocorticoid Receptors RT to a DNA Binding State under Cell-free Conditions RL J. Biol. Chem. 256:2269-2277 (1990). RN [4] RA Elferink C. J., Gasiewicz T. A., Whitlock J. P., jr. - RT Protein-DNA interactions at a dioxin-responsive enhancer RL J. Biol. Chem. 265:20708-20712 (1990). XX // AC T00196 XX ID T00196 XX DT 15.10.92 (created); ewi. DT 05.11.96 (updated); ewi. XX FA Dl XX SY Dorsal; dl; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0020; Rel; 4.1.1.0.7. XX SZ 678 AA; 75.5 kDa (cDNA) XX SQ MFPNQNNGAAPGQGPAVDGQQSLNYNGLPAQQQQQLAQSTKNVRKKPYVKITEQPAGKAL SQ RFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPYRPHPHNLVG SQ KEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSHRFQP SQ SSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKAMSDLVICRLCSCSATVFGN SQ TQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITE SQ PAKVFIQLRRPSDGVTSEALPFEYVPMDSDPAHLRRKRQKTGGDPMHLLLQQQQKQQLQN SQ DHQDGRQTNMNCWNTQNIPPIKTEPRDTSPQPFGLSYRAPPELTPSPQPLSPSSNYNHNS SQ TPSPYNMASAVTPTNGQQQLMSPNHPQQQQQQQQYGATDLGSNYNPFAQQVLAQQQQHQQ SQ QQQQHQHQHQQQHQQQQQQQQQQQQQQSLQFHANPFGNPGGNSWESKFSAAAVAAAAATA SQ TGAAPANGNSNNLSNLNNPFTMHNLLTSGGGPGNANNLQWNLTTNHLHNQHTLHQQQQLQ SQ QQQQQQYDNTAPTNNNANLNNNNNNNNTAGNQADNNGPTLSNLLSFDSGQLVHINSEDQQ SQ ILRLNSEDLQISNLSIST XX SC SwissProt #P15330 XX FT 1 378 DNA-binding domain FT 47 340 Rel homology region XX FF morphogen, establishes dorsal-ventral polarity in embryogenesis; FF complexed and cytoplasmically retained by Cactus [3]; FF proteolytic degradation of Cactus allows nuclear translocation FF of Dorsal [3]; FF the responsible signal is mediated by a protein kinase FF encoded by pelle gene [4]; FF cooperative DNA-binding with Scute (T00004) to activate FF genes in lateral embryonic regions [1]; XX IN T01933; Cactus; fruit fly, Drosophila melanogaster. XX MX M00043; I$DL_01 MX M00120; I$DL_02 XX BS R03463; DORSAL$CONS_01; Quality: 6 BS R04108; DORSAL$CONS_02; Quality: 2 BS R04306; DROME$SNA_01; Quality: 2; fruit fly, Drosophila melanogaster BS R04307; DROME$SNA_02; Quality: 2; fruit fly, Drosophila melanogaster BS R04308; DROME$SNA_03; Quality: 2; fruit fly, Drosophila melanogaster BS R04309; DROME$SNA_04; Quality: 2; fruit fly, Drosophila melanogaster BS R04310; DROME$SNA_05; Quality: 2; fruit fly, Drosophila melanogaster BS R04311; DROME$SNA_06; Quality: 2; fruit fly, Drosophila melanogaster BS R04312; DROME$SNA_07; Quality: 2; fruit fly, Drosophila melanogaster BS R04313; DROME$SNA_08; Quality: 2; fruit fly, Drosophila melanogaster BS R04314; DROME$SNA_09; Quality: 2; fruit fly, Drosophila melanogaster BS R04315; DROME$SNA_10; Quality: 2; fruit fly, Drosophila melanogaster BS R01716; DROME$TWI_01; Quality: 2; fruit fly, Drosophila melanogaster BS R01717; DROME$TWI_02; Quality: 2; fruit fly, Drosophila melanogaster BS R01718; DROME$TWI_03; Quality: 2; fruit fly, Drosophila melanogaster BS R01719; DROME$TWI_04; Quality: 2; fruit fly, Drosophila melanogaster BS R01720; DROME$TWI_05; Quality: 2; fruit fly, Drosophila melanogaster BS R01721; DROME$TWI_06; Quality: 2; fruit fly, Drosophila melanogaster BS R01722; DROME$TWI_07; Quality: 2; fruit fly, Drosophila melanogaster BS R03460; DROME$TWI_08; Quality: 2; fruit fly, Drosophila melanogaster BS R03461; DROME$TWI_09; Quality: 2; fruit fly, Drosophila melanogaster BS R03462; DROME$TWI_10; Quality: 2; fruit fly, Drosophila melanogaster BS R01723; DROME$ZEN_01; Quality: 2; fruit fly, Drosophila melanogaster BS R02852; DROME$ZEN_02; Quality: 2; fruit fly, Drosophila melanogaster BS R02853; DROME$ZEN_03; Quality: 2; fruit fly, Drosophila melanogaster BS R02854; DROME$ZEN_04; Quality: 2; fruit fly, Drosophila melanogaster XX DR EMBL: M23702; DMDORSAL(r). DR SwissProt: P15330; DORS_DROME. DR PIR: A30350; A30350. DR Flybase: FBgn0000462; dl. XX RN [1] RA Jiang J., Levine M. RT Binding affinities and cooperative interactions with RT bHLH activators delimit threshold responses to the dorsal gradient morphogen RL Cell 72:741-752 (1993). RN [2] RA Thisse C., Perrin-Schmitt F., Stoetzel C., Thisse B. RT Sequence-specific transactivation of the Drosophila RT twist gene by the dorsal gene product RL Cell 65:1191-1201 (1991). RN [3] RA Belvin M. P., Jin Y., Anderson K. V. RT Cactus protein degradation mediates Drosophila dorsal-ventral signaling RL Genes Dev. 9:783-793 (1995). RN [4] RA Shelton C. A., Wasserman S. A. RT pelle encodes a protein kinase required to establish RT dorsoventral polarity in the Drosophila embryo RL Cell 72:515-525 (1993). RN [5] RA Ip Y. T., Kraut R., Levine M., Rushlow C. A. RT The dorsal morphogen if a sequence-specific DNA-binding RT protein that interacts with a long-range repression element in Drosophila RL Cell 64:439-446 (1991). XX // AC T00197 XX ID T00197 XX DT 14.04.93 (created); ewi. DT 23.05.97 (updated); hiwi. XX FA Dr1 XX SY DBF2; NC2; negative cofactor 2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 176 AA; 19 kDa (SDS), 19.3 kDa (cDNA) XX SQ MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNK SQ SEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLR SQ QQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI XX SC SwissProt #Q01658 XX FT 130 150 glutamine-/alanine-rich region (14/21) XX SF Phosphorylation, potential phosphorylation sites for PKA, PKC, CKII SF HAP2-homologous N-terminus (31%) XX FF transcription repressor, binds to TBP and precludes FF TBP-TFIIA-interaction when phosphorylated XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX BS R03156; AD$MLP_39; Quality: 6; adenovirus XX DR EMBL: M97388; HSDR1TATA(r). DR SwissProt: Q01658; TBAP_HUMAN. DR PIR: A43320; A43320. XX RN [1] RA Kim T. K., Zhao Y., Ge H., Bernstein R., Roeder R. G. RT TATA-binding protein residues implicated in a functional RT interplay between negative cofactor NC2(Dr1) and general RT factors TFIIA and TFIIB RL J. Biol. Chem. 270:10976-10981 (1995). RN [2] RA White R. J., Khop B. C.-E., Inostroza J. A., Reinberg D., Jackson S. P. RT Differential regulation of RNA Polymerase I, II and RT III by the TBP-binding repressor Dr1 RL Science 266:448-450 (1994). RN [3] RA Kraus V. B., Inostroza J. A., Yeung K., Reinberg D., Nevins J. R. RT Interaction of the Dr1 inhibitory factor with the RT TATA binding protein is disrupted by adenovirus E1A RL Proc. Natl. Acad. Sci. USA 91:6279-6282 (1994). RN [4] RA Inostroza J. A., Mermelstein F. H., Ha I., Lane W. S., Reinberg D. RT Dr1, a TATA-binding protein-associated phosphoprotein RT and inhibitor of class II gene transcription RL Cell 70:477-489 (1992). RN [5] RA Meisterernst M., Roeder R. G. RT Family of proteins that interact with TFIID and regulate promoter activity RL Cell 67:557-567 (1991). XX // AC T00198 XX ID T00198 XX DT 14.12.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA DRTF1 XX SY differentiation regulated factor 1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 1.3.2.4.1. XX SZ 200-250 kDa (GF), 50 kDa, 30 kDa (SDS) XX SF p50 and p30 are DNA-contacting polypeptides of DRTF complexes 1b and 1c SF DRTF complex 1a is phosphorylation-dependent SF like E2F, DRTF1 binding activity appears to be composed SF of a E2F- and a DP-component (E2F-1, -2, -3, -4 and DP-1, resp.) [4]; XX FF down-regulated during differentiation; FF functionally related to, but different from E2F (human) XX IN T01423; Rb; mouse, Mus musculus. XX BS R00326; AD$E2AE1_12; Quality: 6; adenovirus BS R02687; AD$E2AE1_20; Quality: 6; adenovirus type 5 BS R03467; AD$E2AE1_22; Quality: 6; adenovirus type 5 XX DR EMBL: X72310; MMDP1(r). XX RN [1] RA Murray E. J., Stott D., Rigby P. W. J. RT Sequences and factors required for the F9 embryonal RT carcinoma stem cell E1a-like activity RL Mol. Cell. Biol. 11:5534-5540 (1991). RN [2] RA Shivji M. K. K., La Thangue N. B. RT Multicomponent differentiation-regulated transcription RT factors in F9 embryonal carcinoma stem cells RL Mol. Cell. Biol. 11:1686-1695 (1991). RN [3] RA Partridge J. F., La Thangue N. B. RT A developmentally regulated and tissue-dependent transcription RT factor complexes with the retinoblastoma gene product RL EMBO J. 10:3819-3827 (1991). RN [4] RA Girling R., Partridge J. F., Bandara L. R., Burden RA N., Totty N. F., Hsuan J. J., La Thangue N. B. RT A new component of the transcription factor DRTF1/E2F RL Nature 362:83-87 (1993). RN [5] RA La Thangue N. B., Thimmappaya B., Rigby P. W. J. RT The embryonal carcinoma stem cell E1a-like activity RT involves a differentiation-regulated transcription factor RL Nucleic Acids Res. 18:2929-2938 (1990). XX // AC T00199 XX ID T00199 XX DT 14.12.92 (created); ewi. XX FA DRTF2 XX SY differentiation regulated factor 2; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R02688; AD$E2AE1_21; Quality: 6; adenovirus type 5 XX RN [1] RA La Thangue N. B., Thimmappaya B., Rigby P. W. J. RT The embryonal carcinoma stem cell E1a-like activity RT involves a differentiation-regulated transcription factor RL Nucleic Acids Res. 18:2929-2938 (1990). XX // AC T00200 XX ID T00200 XX DT 15.10.92 (created); ewi. XX FA DTF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 40 kDa XX BS R01012; AD$MLP_27; Quality: 6; adenovirus XX RN [1] RA Cohen R. B., Yang L., Thompson J. A., Safer B. RT Identification of a Downstream Sequence and Binding RT Protein That Regulate Adenovirus Major Late Promoter Transcription in Vitro RL J. Biol. Chem. 263:10377-10385 (1988). XX // AC T00201 XX ID T00201 XX DT 15.10.92 (created); ewi. XX FA DTF-1 XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX SZ 50 kDa XX BS R01873; DROME$ANTP_07; Quality: 6; fruit fly, Drosophila melanogaster BS R01874; DROME$ANTP_08; Quality: 6; fruit fly, Drosophila melanogaster XX DR Flybase: FBgn0013910; Dtf-1. XX RN [1] RA Perkins K. K., Dailey G. M., Tjian R. RT In vitro analysis of the Antennapedia P2 promoter: RT identification of a new Drosophila transcription factor RL Genes Dev. 2:1615-1626 (1988). XX // AC T00202 XX ID T00202 XX DT 15.10.92 (created); ewi. XX FA E XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF related to AP-1 XX BS R00639; HBV$HBVE_10; Quality: 6; HBV, human hepatitis B virus BS R00138; HS$APOA2_03; Quality: 6; human, Homo sapiens XX RN [1] RA Ben-Levy R., Faktor O., Berger I., Shaul Y. RT Cellular Factors That Interact with the Hepatitis B Virus Enhancer RL Mol. Cell. Biol. 9:1804-1809 (1989). XX // AC T00203 XX ID T00203 XX DT 25.01.93 (created); ewi. XX FA E1 XX OS BPV-1, bovine papilloma virus type 1 OC viridae; ds-DNA nonenveloped viruses; papovaviridae; papillomavirus XX SZ 68 kDa XX FT 384 516 essential for E2 contact XX FF required for virus replication, targeted to origin FF of replication by complexing with E2 XX IN T00205; E2; BPV-1, bovine papilloma virus type 1. XX RN [1] RA Bradley D. W., Dou Q.-P., Fridovich-Keil J. L., Pardee A. B. RT Transformed and nontransformed cells differ in stability RT and cell cycle regulation of a binding activity to RT the murine thymidine kinase promoter RL Proc. Natl. Acad. Sci. USA 87:9310-9314 (1990). RN [2] RA Mohr I. J., Clark R., Sun S., Androphy E. J., MacPherson P., Botchan M. R. RT Targeting the E1 replication protein to the papillomavirus RT origin of replication by complex formation with the E2 transactivator RL Science 250:1694- (1990). RN [3] RA Lusky M., Fontane E. RT Formation of the complex of bovine papillomavirus RT E1 and E2 proteins is modulated by E2 phosphorylation RT and depends upon sequences within the carboxyl terminus of E1 RL Proc. Natl. Acad. Sci. USA 88:6363-6367 (1991). XX // AC T00204 XX ID T00204 XX DT 15.10.92 (created); ewi. DT 20.05.97 (updated); ewi. XX FA E12 XX SY E2-alpha; E2A-E12; E2A.E12; Pan-2 (rat); TCF3; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0010; bHLH; 1.2.1.0.1.1. XX SZ 654 AA; 67.4 kDa (cDNA) XX SQ MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWG SQ SGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLGPGLGGKSGERGAYASFGRDAGVGGL SQ TQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL SQ PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPML SQ GGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGAT SQ YGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP SQ QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLP SQ GHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPD SQ SYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSPDEDEDDLLPP SQ EQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLNSEKPQTKLLILHQAVSVIL SQ NLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQMVLSAPHPGLSEAHNPAGHM XX SC SwissProt #P15923 XX FT 348 406 trans-activation domain [8]; FT 348 394 homology box 1 (putative loop) FT 397 406 homology box 2 (putative amphiphilic alpha-helix) FT 530 549 inhibitory A domain [5], [20]; FT 397 425 putative leucine repeat (L2TL2) FT 550 561 basic region FT 562 603 helix-loop-helix domain FT 530 601 E12-specific region FT 458 472 potential leucine repeat (L3) FT 576 576 cysteine involved in disulfide-linkage FT between homodimer constituents [15]; FT 1 83 trans-activation domain [8]; XX SF class A specific domain [20]; SF putative leucine zipper motif (L2TL2) may be N-terminally SF extended due to the lack of Q390 in [22]; SF spontaneous homodimerization in B cells, stabilized by disulfide links [15]; SF reducing activity in muscle cells provides monomers SF that preferentially heterodimerize with, e. g., MyoD [15]; SF dimerization specificity with MyoD is defined by several SF hydrogen bonds and charged pairs [3]; SF trans-activation domain may comprise a novel loop-helix motif [8]; SF the trans-activating domain at 348-406 is targeted SF by the bZIP domain of c-Jun when repressing the activation SF potential of E2A proteins [16]; XX CP ubiquitous XX FF activator [8]; FF poorly DNA-binding as homodimer due to an inhibitory FF N-terminal domain, but avid DNA-binding in any heterodimeric FF complex [5], [20]; FF the inhibitory region also defines different DNA-binding FF specificities between E12 and E47 [20], [21]; FF may be involved in tissue-specific gene regulation FF of muscle, lymphoid, or neural cells when heterodimerizing FF with cell-specific components; FF growth-inhibitory activity [14]; FF despite functional redudancy with other related factors FF (E2A or E2-2 gene products), only E12/E47 are found in mature B cells [7]; XX IN T00003; AS-C T3; fruit fly, Drosophila melanogaster. IN T00036; AP-4; human, Homo sapiens. IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00405; IEBP1; rat, Rattus norvegicus. IN T00484; MASH-1; rat, Rattus norvegicus. IN T00485; MASH-2; rat, Rattus norvegicus. IN T00506; MEF1; mouse, Mus musculus. IN T00512; MRF4; rat, Rattus norvegicus. IN T00520; Myf-4; human, Homo sapiens. IN T00521; Myf-5; human, Homo sapiens. IN T00522; Myf-6; human, Homo sapiens. IN T00524; MyoD; clawed frog, Xenopus laevis. IN T00525; MyoD; human, Homo sapiens. IN T00526; MyoD; mouse, Mus musculus. IN T00527; MyoD; monkey, Cercopithecus aethiops. IN T00528; myogenin; mouse, Mus musculus. IN T00674; E47; rat, Rattus norvegicus. IN T00790; Tal-1; human, Homo sapiens. IN T00926; SUM-1; sea urchin, Lytechinus variegatus. IN T00949; Myf-5; clawed frog, Xenopus laevis. IN T01128; MyoD; chick, Gallus gallus. IN T01212; Id2; human, Homo sapiens. IN T01447; HEN1; rat, Rattus norvegicus. IN T01503; HEB; human, Homo sapiens. IN T01569; Th1; mouse, Mus musculus. IN T01619; MASH-1; mouse, Mus musculus. IN T01620; MASH-1; human, Homo sapiens. IN T01621; ASH-1; clawed frog, Xenopus laevis. IN T01653; Delilah; fruit fly, Drosophila melanogaster. IN T01788; E47; mouse, Mus musculus. IN T01794; INSAF; human, Homo sapiens. XX BS R04244; AS$HEN1_01; Quality: 2 BS R03109; CHICK$ACC_03; Quality: 1; chick, Gallus gallus BS R02139; E2A$CONS; Quality: 1 BS R04418; MOUSE$HBEGF_01; Quality: 2; mouse, Mus musculus BS R00881; MOUSE$IGKL_05; Quality: 6; mouse, Mus musculus BS R00882; MOUSE$IGKL_06; Quality: 6; mouse, Mus musculus BS R00883; MOUSE$IGKL_07; Quality: 6; mouse, Mus musculus BS R00240; MOUSE$MCK_01; Quality: 6; mouse, Mus musculus BS R00241; MOUSE$MCK_02; Quality: 6; mouse, Mus musculus BS R00242; MOUSE$MCK_03; Quality: 2; mouse, Mus musculus BS R02898; QUAIL$STN1_01; Quality: 2; quail, Coturnix coturnix BS R03074; RAT$MLC_01; Quality: 2; rat, Rattus norvegicus XX DR EMBL: M24405; HSIMENBPA(g). DR EMBL: M31523; HSTFAA(r). DR SwissProt: P15923; TFE2_HUMAN. DR PIR: A31492; A31492. DR PIR: A34734; A34734. XX RN [1] RA Hsu H.-L., Huang L., Tsan J. T., Funk W., Wright W. RA E., Hu J.-S., Kingston R. E., Baer R. RT Preferred sequences for DNA recognition by the TAL1 RT helix-loop-helix proteins RL Mol. Cell. Biol. 14:1256-1265 (1994). RN [2] RA Hu J.-S., Olson E. N., Kingston R. E. RT HEB, a helix-loop-helix protein related to E2A and RT ITF2 that can modulate the DNA-binding ability of RT myogenic regulatory factors RL Mol. Cell. Biol. 12:1031-1042 (1992). RN [3] RA Shirakata M., Friedman F. K., Wei Q., Paterson B. M. RT Dimerization specificity of myogenic helix-loop-helix RT DNA-binding factors directed by nonconserved hydrophilic residues RL Genes Dev. 7:2456-2470 (1993). RN [4] RA Chakraborty T., Martin J. F., Olson E. N. RT Analysis of the oligomerization of myogenin and E2A RT products in vivo using a two-hybrid assay system RL J. Biol. Chem. 267:17498-17501 (1992). RN [5] RA Murre C., McCaw P. S., Vaessin H., Caudy M., Jan L. RA Y., Jan Y. N., Cabrera C. V., Buskin J. N., Hauschka RA S. D., Lassar A. B., Weintraub H., Baltimore D. RT Interactions between heterologous helix-loop-helix RT proteins generate complexes that bind specifically to a common DNA sequence RL Cell 58:537-544 (1989). RN [6] RA Benezra R., Davis R. L., Lockshon D., Turner D. L., Weintraub H. RT The protein Id: a negative regulator of helix-loop-helix RT DNA binding proteins RL Cell 61:49-59 (1990). RN [7] RA Bain G., Gruenwald S., Murre C. RT E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins RL Mol. Cell. Biol. 13:3522-3529 (1993). RN [8] RA Quong M. W., Massari M. E., Zwart R., Murre C. RT A new transcriptional-activation motif restricted RT to a class of helix-loop-helix proteins is functionally RT conserved in both yeast and mammalian cells RL Mol. Cell. Biol. 13:792-800 (1993). RN [9] RA Sawada S., Littman D. R. RT A heterodimer of HEB and an E12-related protein interacts RT with the CD4 enhancer and regulates its activity in T-cell lines RL Mol. Cell. Biol. 13:5620-5628 (1993). RN [10] RA Kamps M. P., Murre C., Sun X. H., Baltimore D. RT A new homeobox gene contributes the DNA binding domain RT oft the t(1; 19) translocation protein in pre-B ALL RL Cell 60:547-555 (1990). RN [11] RA Mellentin J. D., Murre C., Donlon T. A., McCaw P. RA S., Smith S. D., Carroll A. J., McDonald M. E., Baltimore D., Cleary M. L. RT The gene for enhancer binding proteins E12/E47 lies RT at the t(1;19) breakpoint in acute leukemias RL Science 246:379-382 (1989). RN [12] RA Kamps M. P., Baltimore D. RT E2A-Pbx1, the t(1;19) translocation protein of human RT pre-B-cell acute lymphocytic leukemia causes acute myeloid leukemia in mice RL Mol. Cell. Biol. 13:351-357 (1993). RN [13] RA Staudinger J., Perry M., Elledge S. J., Olson E. N. RT Interactions among vertebrate helix-loop-helix proteins RT in yeast using the two-hybrid system RL J. Biol. Chem. 268:4608-4611 (1993). RN [14] RA Peverali F. A., Ramqvist T., Saffrich R., Pepperkok RA R., Barone M. V., Philipson L. RT Regulation of G1 progression by E2A and Id helix-loop-helix proteins RL EMBO J. 13:4291-4301 (1994). RN [15] RA Benezra R. RT An intermolecular disulfide bond stabilizes E2A homodimers RT and is required for DNA binding at physiological temperatures RL Cell 79:1057-1067 (1994). RN [16] RA Robinson G. L. W. G., Henderson E., Massari M. E., Murre C., Stein R. RT c-Jun inhibits insulin control element-mediated transcription RT by affecting the transactivation potential of the E2A gene products RL Mol. Cell. Biol. 15:1398-1404 (1995). RN [17] RA Nelson C., Shen L.-P., Meister A., Fodor E., Rutter W. J. RT Pan: a transcriptional regulator that binds chymotrypsin, RT insulin, and AP-4 enhancer motifs RL Genes Dev. 4:1035-1043 (1990). RN [18] RA Chakraborty T., Brennan T., Olson E. RT Differential trans-activation of a muscle-specific RT enhancer by myogenic helix-loop-helix proteins is separable from DNA binding RL J. Biol. Chem. 266:2878-2882 (1991). RN [19] RA French B. A., Chow K.-L., Olson E. N., Schwartz R. J. RT Heterodimers of myogenic helix-loop-helix regulatory RT factors and E12 bind a complex element governing myogenic RT induction of the avian cardiac alpha-actin promoter RL Mol. Cell. Biol. 11:2439-2450 (1991). RN [20] RA Sun X.-H., Baltimore D. RT An inhibitory domain of E12 transcription factor prevents RT DNA binding in E12 homodimers but not in E12 heterodimers RL Cell 64:459-470 (1991). RN [21] RA Chakraborty T., Brennan T. J., Li L., Edmondson D., Olson E. N. RT Inefficient homooligomerization contributes to the RT dependence of myogenin on E2A products for efficient DNA binding RL Mol. Cell. Biol. 11:3633-3641 (1991). RN [22] RA Murre C., McCaw P. S., Baltimore D. RT A new DNA binding and dimerization motif in immunoglobulin RT enhancer binding, daughterless, MyoD, and myc proteins RL Cell 56:777-783 (1989). RN [23] RA Murre C., Voronova A., Baltimore D. RT B-cell- and myocyte-specific E2-box-binding factors RT contain E12/E47-like subunits RL Mol. Cell. Biol. 11:1156-1160 (1991). RN [24] RA Nourse J., Mellentin J. D., Galili N., Wilkinson J., RA Stanbridge E., Smith S. D., Cleary M. L. RT Chromosomal translocation t(1;19) results in synthesis RT of a homeobox fusion mRNA that codes for a potential RT chimeric transcription factor RL Cell 60:535-545 (1990). RN [25] RA Ruezinsky D., Beckmann H., Kadesh T. RT Modulation of the Igh enhancer's cell type through a genetic switch RL Genes Dev. 5:29-37 (1991). RN [26] RA Kamps M. P., Look A. T., Baltimore D. RT The human t(1;19) translocation in pre-B ALL produces RT multiple nuclear E2A-Pbx1 fusion proteins with differing RT transforming potentials RL Genes Dev. 5:358-368 (1991). RN [27] RA Schlissel M., Voronova A., Baltimore D. RT Helix-loop-helix transcription factor E47 activates RT germ-line immunoglobulin heavy-chain gene transcription RT and rearrangement in a pre-T-cell line RL Genes Dev. 5:1367-1376 (1991). XX // AC T00205 XX ID T00205 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA E2 XX OS BPV-1, bovine papilloma virus type 1 OC viridae; ds-DNA nonenveloped viruses; papovaviridae; papillomavirus XX CL ; ; 4.4.1.0.1. XX SZ 46-50 kDa (SDS), 85-110 kDa (SDS) XX SF high molecular weight (> 85 kDa) after crosslinking XX FF activator, cooperativity between two E2 sites; FF complexes replication-stimulating viral E1, synergistic FF transcriptional activation with Sp1 XX IN T00203; E1; BPV-1, bovine papilloma virus type 1. IN T00205; E2; BPV-1, bovine papilloma virus type 1. IN T00752; Sp1; mouse, Mus musculus. IN T00753; Sp1; domestic pig, Sus scrofa. IN T00754; Sp1; rat, Rattus norvegicus. IN T00755; Sp1; chick, Gallus gallus. IN T00757; Sp1; monkey, Cercopithecus aethiops. IN T00758; Sp1; clawed frog, Xenopus. IN T00759; Sp1; human, Homo sapiens. IN T01228; Sp1; hamster. XX MX M00107; V$E2_01 XX BS R03720; AS$E2SP1_01; Quality: 6 BS R03702; AS$E2TBP_01; Quality: 6; HPV-18, human papilloma virus type 18 BS R03704; AS$E2TBP_03; Quality: 6; HPV-18, human papilloma virus type 18 BS R00171; BPV1$BPV1_01; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00172; BPV1$BPV1_02; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00173; BPV1$BPV1_03; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00174; BPV1$BPV1_04; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00175; BPV1$BPV1_05; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00176; BPV1$BPV1_06; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00177; BPV1$BPV1_07; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00178; BPV1$BPV1_08; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00179; BPV1$BPV1_09; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00180; BPV1$BPV1_10; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00181; BPV1$BPV1_11; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00182; BPV1$BPV1_12; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00184; BPV1$BPV1_14; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00185; BPV1$BPV1_15; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00186; BPV1$BPV1_16; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00187; BPV1$BPV1_17; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00188; BPV1$BPV1_18; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00189; BPV1$BPV1_19; Quality: 6; BPV-1, bovine papilloma virus type 1 BS R00190; BPV1$BPV1_20; Quality: 2; BPV-1, bovine papilloma virus type 1 BS R00191; BPV1$BPV1_21; Quality: 2; BPV-1, bovine papilloma virus type 1 BS R00192; BPV1$BPV1_22; Quality: 2; BPV-1, bovine papilloma virus type 1 BS R00193; BPV1$BPV1_23; Quality: 2; BPV-1, bovine papilloma virus type 1 BS R03701; HPV$HPV18_06; Quality: 6; HPV-18, human papilloma virus type 18 BS R00743; HPV$HPV18_07; Quality: 6; HPV-18, human papilloma virus type 18 XX DR EMBL: X05817; PABPV4XX(g). DR EMBL: X02346; PAPABPV1(g). DR EMBL: M20219; PAPPPB2C(g). DR SwissProt: P03122; VE2_BPV1. DR SwissProt: P11299; VE2_BPV2. DR SwissProt: P08345; VE2_BPV4. DR PIR: A94519; W2WLB2. DR PIR: F27129; W2WLB4. DR PIR: A03672; W2WLEB. XX RN [1] RA Hawley-Nelson P., Androphy E. J., Lowy D. R., Schiller J. T. RT The specific DNA recognition sequence of the bovine RT papillomavirus E2 protein is an E2-dependent enhancer RL EMBO J. 7:525-531 (1988). RN [2] RA Moskaluk C., Bastia D. RT DNA bending is induced in an enhancer by the DNA-binding RT domain of the bovine papillomavirus E2 protein RL Proc. Natl. Acad. Sci. USA 85:1826-1830 (1988). RN [3] RA Moskaluk C., Bastia D. RT The E2 gene of bovine papillomavirus encodes an enhancer-binding protein RL Proc. Natl. Acad. Sci. USA 84:1215-1218 (1987). RN [4] RA Lambert P. F., Dostatni N., McBride A. A., Yaniv M., RA Howley P. M., Arcangioli B. RT Functional analysis of the papilloma virus E2 trans-activator RT in Saccharomyces cerevisiae RL Genes Dev. 3:38-48 (1989). RN [5] RA Mohr I. J., Clark R., Sun S., Androphy E. J., MacPherson P., Botchan M. R. RT Targeting the E1 replication protein to the papillomavirus RT origin of replication by complex formation with the E2 transactivator RL Science 250:1694- (1990). RN [6] RA Dostatni N., Thierry F., Yaniv M. RT A dimer of BPV-1 E2 containing a protease resistant RT core interacts with its DNA target RL EMBO J. 7:3807-3816 (1988). RN [7] RA Knight J. D., Li R., Botchan M. RT The activation domain of the bovine papillomavirus RT E2 protein mediates association of DNA-bound dimers to form DNA loops RL Proc. Natl. Acad. Sci. USA 88:3204-3208 (1991). RN [8] RA Lusky M., Fontane E. RT Formation of the complex of bovine papillomavirus RT E1 and E2 proteins is modulated by E2 phosphorylation RT and depends upon sequences within the carboxyl terminus of E1 RL Proc. Natl. Acad. Sci. USA 88:6363-6367 (1991). RN [9] RA Li R., Knight J. D., Jackson S. P., Tijan R., Botchan M. R. RT Direct interaction between Sp1 and the BPV Enhancer RT E2 protein mediates synergistic activation of transcription RL Cell 65:493-505 (1991). XX // AC T00206 XX ID T00206 XX DT 15.10.92 (created); ewi. XX FA E4 XX OS adenovirus type 5 OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX IN T00219; E2F; mouse, Mus musculus. IN T00220; E2F; monkey, Cercopithecus aethiops. IN T00221; E2F; human, Homo sapiens. XX RN [1] RA Boeuf H., Reimund B., Jansen-Durr P., Kedinger C. RT Differential activation of the E2F transcription factor RT by the adenovirus EIa and EIV products in F9 cells RL Proc. Natl. Acad. Sci. USA 87:1782-1786 (1990). RN [2] RA Neill S. D., Hemstrom C., Virtanen A., Nevins J. R. RT An adenovirus E4 gene product trans-activates E2 transcription RT and stimulates stable E2F binding through a direct association with E2F RL Proc. Natl. Acad. Sci. USA 87:2008-2012 (1990). RN [3] RA Huang M.-M., Hering P. RT The adenovirus early 4 open reading frame 6/7 protein RT regulates the DNA binding activity of the cellular RT transcription factor, E2F, through a direct complex RL Genes Dev. 3:1699-1710 (1989). RN [4] RA Hardy S., Engel D. A., Shenk T. RT An adenovirus early region 4 gene product is required RT for induction of the infection-specific form of cellular E2F activity RL Genes Dev. 3:1062-1074 (1989). XX // AC T00207 XX ID T00207 XX DT 20.10.92 (created); ewi. DT 20.05.97 (updated); ewi. XX FA E47 XX SY BCF-1; E2A-E47; E2A.E47; IEBP1 (rat); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0010; bHLH; 1.2.1.0.1.2. XX SZ 651 AA; 67.3 kDa (cDNA) XX SQ MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWG SQ SGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLGPGLGGKSGERGAYASFGRDAGVGGL SQ TQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL SQ PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPML SQ GGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGAT SQ YGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP SQ QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLP SQ GHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPD SQ SYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSSTDEVLSLEEK SQ DLRDRERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLE SQ QQVRERNLNPKAACLKRREEEKVSGVVGDPQMVLSAPHPGLSEAHNPAGHM XX SC reconstituted from hE12 (common N- and C-termini) and conceptually translated fragments from EMBL/GenBank/DDBJ #M65214 and #M24404 XX FT 397 425 leucine repeat (L2TL2) FT 547 556 basic region FT 557 600 helix-loop-helix domain FT 345 408 trans-activation domain [5]; FT 1 83 trans-activation domain [5]; XX SF basic region contacts DNA, HLH domain is the dimerization interface [1]; SF binds DNA avidly as homodimer (contrasting to E12), or as heterodimer [11]; SF from crystal structure: dimerization domain forms SF a parallel four-helix-bundle [7]; SF helix 1 is one turn longer than in other bHLH proteins SF and does not terminate with a proline, the additional SF turn allowing a salt bridge to form between H576 (at SF the end of helix 1) and E600 of helix 2 of the other E47 peptide [7]; SF trans-activation domain is identical with that of E12 SF that around 345-408 is targeted by the bZIP of c-Jun SF when repressing activation by E2A proteins [8]; XX CP ubiquitous XX FF part of MEF-1 complex; FF induces hyperphosphorylation of MyoD upon association; FF induces transcription of IgH, but also of IgH-stimulating FF Oct-2 gene, and recombination-activating genes RAG-1 FF and -2 thus stimulating IgH rearrangement as well [18]; XX IN T00003; AS-C T3; fruit fly, Drosophila melanogaster. IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00404; Id2; mouse, Mus musculus. IN T00506; MEF1; mouse, Mus musculus. IN T00512; MRF4; rat, Rattus norvegicus. IN T00520; Myf-4; human, Homo sapiens. IN T00521; Myf-5; human, Homo sapiens. IN T00522; Myf-6; human, Homo sapiens. IN T00524; MyoD; clawed frog, Xenopus laevis. IN T00525; MyoD; human, Homo sapiens. IN T00526; MyoD; mouse, Mus musculus. IN T00527; MyoD; monkey, Cercopithecus aethiops. IN T00528; myogenin; mouse, Mus musculus. IN T00675; E12; rat, Rattus norvegicus. IN T00790; Tal-1; human, Homo sapiens. IN T00949; Myf-5; clawed frog, Xenopus laevis. IN T01128; MyoD; chick, Gallus gallus. IN T01212; Id2; human, Homo sapiens. IN T01447; HEN1; rat, Rattus norvegicus. IN T01448; Tal-1beta; human, Homo sapiens. IN T01569; Th1; mouse, Mus musculus. IN T01629; MATH-2; mouse, Mus musculus. IN T01630; Tal-2; human, Homo sapiens. IN T01631; Tal-2; mouse, Mus musculus. IN T01634; BETA2; hamster. IN T01652; HES-5; rat, Rattus norvegicus. IN T01658; Id4; mouse, Mus musculus. IN T01787; E12; clawed frog, Xenopus laevis. XX MX M00002; V$E47_01 MX M00065; V$TAL1BETAE47_01 MX M00066; V$TAL1ALPHAE47_01 MX M00071; V$E47_02 MX M00222; V$TH1E47_01 XX BS R04157; AS$TAL1_01; Quality: 2 BS R02139; E2A$CONS; Quality: 1 BS R00850; MOUSE$IGH_16; Quality: 6; mouse, Mus musculus BS R04158; MOUSE$IGH_59; Quality: 2; mouse, Mus musculus BS R00881; MOUSE$IGKL_05; Quality: 6; mouse, Mus musculus BS R00882; MOUSE$IGKL_06; Quality: 6; mouse, Mus musculus BS R00884; MOUSE$IGKL_08; Quality: 6; mouse, Mus musculus BS R00241; MOUSE$MCK_02; Quality: 6; mouse, Mus musculus BS R00242; MOUSE$MCK_03; Quality: 2; mouse, Mus musculus BS R00913; RAT$INS2_01; Quality: 6; rat, Rattus norvegicus XX DR EMBL: M65214; HSE2A(r). DR EMBL: M24404; HSIMENBP(g). DR PDB: 1hlh; E47 PROTEIN PRODUCT OF THE E2A GENE (HELIX-LOOP-HELIX DOMAIN) HUMAN. XX RN [1] RA Voronova A., Baltimore D. RT Mutations that disrupt DNA binding and dimer formation RT in the E47 helix-loop-helix protein map to distinct domains RL Proc. Natl. Acad. Sci. USA 87:4722-4726 (1990). RN [2] RA Chakraborty T., Martin J. F., Olson E. N. RT Analysis of the oligomerization of myogenin and E2A RT products in vivo using a two-hybrid assay system RL J. Biol. Chem. 267:17498-17501 (1992). RN [3] RA Murre C., McCaw P. S., Vaessin H., Caudy M., Jan L. RA Y., Jan Y. N., Cabrera C. V., Buskin J. N., Hauschka RA S. D., Lassar A. B., Weintraub H., Baltimore D. RT Interactions between heterologous helix-loop-helix RT proteins generate complexes that bind specifically to a common DNA sequence RL Cell 58:537-544 (1989). RN [4] RA Benezra R., Davis R. L., Lockshon D., Turner D. L., Weintraub H. RT The protein Id: a negative regulator of helix-loop-helix RT DNA binding proteins RL Cell 61:49-59 (1990). RN [5] RA Quong M. W., Massari M. E., Zwart R., Murre C. RT A new transcriptional-activation motif restricted RT to a class of helix-loop-helix proteins is functionally RT conserved in both yeast and mammalian cells RL Mol. Cell. Biol. 13:792-800 (1993). RN [6] RA Hsu H.-L., Huang L., Tsan J. T., Funk W., Wright W. RA E., Hu J.-S., Klingston R. E., Baer R. RT Preferred sequence for DNA recognition by the TAL1 helix-loop-helix proteins RL Mol. Cell. Biol. 14:1256-1265 (1991). RN [7] RA Ellenberger T., Fass D., Arnaud M., Harrison S. C. RT Crystal structure of transcription factor E47: E-box RT recognition by a basic region helix-loop-helix dimer RL Genes Dev. 8:970-980 (1994). RN [8] RA Robinson G. L. W. G., Henderson E., Massari M. E., Murre C., Stein R. RT c-Jun inhibits insulin control element-mediated transcription RT by affecting the transactivation potential of the E2A gene products RL Mol. Cell. Biol. 15:1398-1404 (1995). RN [9] RA Cordle S. R., Henderson E., Masuoka H., Weil P. A., Stein R. RT Pancreatic beta-cell-type-specific transcription of RT the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins RL Mol. Cell. Biol. 11:1734-1738 (1991). RN [10] RA Hsu H.-L., Cheng J.-T., Chen Q., Baer R. RT Enhancer-binding activity of the tal-1 oncoprotein RT in association with the E47/E12 helix-loop-helix proteins RL Mol. Cell. Biol. 11:3037-3042 (1991). RN [11] RA Sun X.-H., Baltimore D. RT An inhibitory domain of E12 transcription factor prevents RT DNA binding in E12 homodimers but not in E12 heterodimers RL Cell 64:459-470 (1991). RN [12] RA Lassar A. B., Davis R. L., Wright W. E., Kadesch T., RA Murre C., Voronova A., Baltimore D., Weintraub H. RT Functional activity of myogenic HLH proteins requires RT hetero-oligomerization with E12/E47-like proteins in vivo RL Cell 66:305-315 (1991). RN [13] RA Murre C., McCaw P. S., Baltimore D. RT A new DNA binding and dimerization motif in immunoglobulin RT enhancer binding, daughterless, MyoD, and myc proteins RL Cell 56:777-783 (1989). RN [14] RA Murre C., Voronova A., Baltimore D. RT B-cell- and myocyte-specific E2-box-binding factors RT contain E12/E47-like subunits RL Mol. Cell. Biol. 11:1156-1160 (1991). RN [15] RA Nourse J., Mellentin J. D., Galili N., Wilkinson J., RA Stanbridge E., Smith S. D., Cleary M. L. RT Chromosomal translocation t(1;19) results in synthesis RT of a homeobox fusion mRNA that codes for a potential RT chimeric transcription factor RL Cell 60:535-545 (1990). RN [16] RA Ruezinsky D., Beckmann H., Kadesh T. RT Modulation of the Igh enhancer's cell type through a genetic switch RL Genes Dev. 5:29-37 (1991). RN [17] RA Kamps M. P., Look A. T., Baltimore D. RT The human t(1;19) translocation in pre-B ALL produces RT multiple nuclear E2A-Pbx1 fusion proteins with differing RT transforming potentials RL Genes Dev. 5:358-368 (1991). RN [18] RA Schlissel M., Voronova A., Baltimore D. RT Helix-loop-helix transcription factor E47 activates RT germ-line immunoglobulin heavy-chain gene transcription RT and rearrangement in a pre-T-cell line RL Genes Dev. 5:1367-1376 (1991). XX // AC T00208 XX ID T00208 XX DT 27.10.92 (created); ewi. DT 09.06.97 (updated); ewi. XX FA E74A XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0016; ETS; 3.5.2.0.15.1. XX SZ 829 AA; 87.1 kDa (cDNA) XX SQ MPFIDDALLWCPDNDGRLVGGLDLGTCIADDSTANGTENLNPSIQSAGNPNNPQQSVGGE SQ ILGSVESAGNELNGAAARNVNVVVEPLCGGDSSDELFRSFSESNFEIESLLSDLATVEVK SQ VENEENNNNVITDDDFASVAAAVVANDDLLAKENAQLSAQGLVDSVAASLADSGDAGGQQ SQ ALLAFGSSSSAASAIAAAAAALCGDLINNNNNNSNSNNNSNGNGNHGGGGGGASSGGGVA SQ GDCATKLEYALMGGQPLAEEPRFVTSAAANPLLVEKLMSKCLNIEKRMDKLSDTEIPIVK SQ QSTSPAPQQQLQQQHHLQQQQQQQPHNGSTFAGATALLHIKTEQNTLLTPLQLQQQQQQQ SQ QGLHGAAGNGGSSNGNNAHQQQQPLAIPQRPLLHNLLSGGAIHNPHHRNYTTATTGSFPP SQ SPADSGVSDVDSSSSGGQPCADELKARLGMPPATSASAAAAAAAAAAAAAHLHTGTFLHP SQ NLYQNNAANSLRNIWNRSVGVPDNYYGSSGAGSGGTQPGGPGNPQTPGYLTTSYFNAPTA SQ ATAAASQRGTTINGYHSLHQQQQQQQQSQQSQQQQQLAHQQLSHQQQQALHQQLSHQQQQ SQ QQQQQQQHPHSQLNGPHPHSHPHSHPHSHPHAGQHTHSTIAAAAAAAAASVVSSSSSAVA SQ AAAMLSASAAAAATAAAAAGGSQSVIQPATSSVSYDLSYMLELGGFQQRKAKKPRKPKLE SQ MGVKRRSREGSTTYLWEFLLKLLQDREYCPRFIKWTNREKGVFKLVDSKAVSRLWGMHKN SQ KPDMNYETMGRALRYYYQRGILAKVDGQRLVYHFVDVPKDIIEIDCNGV XX SC SwissProt #P20105 XX FT 736 775 tryptophan cluster (W-X18-W-X19-W) FT 1 293 replaced by 1-347 in E74B XX CP late third instar larvae: widespread, highest level CP in brain and other nervous tissue, proventriculus of gut, salvary XX FF ecdysone-induced, subsequently repressed by other FF ecdysone-induced proteins [2]; FF expression peaks at 18-24 h during embryonal development FF and re-appears at 36-58, at 60-72 h, at 108-120 h FF (third instar larvae), at 144-180 (pupae), and in adult flies [2]; FF some peaks are due to ecdysone induction, others to distinct inducers [2]; XX MX M00016; I$E74A_01 XX BS R02386; DROME$E74_09; Quality: 6; fruit fly, Drosophila melanogaster BS R02387; DROME$E74_10; Quality: 6; fruit fly, Drosophila melanogaster BS R02388; DROME$E74_11; Quality: 6; fruit fly, Drosophila melanogaster BS R02389; E74A$CONS; Quality: 6 XX DR EMBL: M37082; DME74A(r). DR SwissProt: P20105; E74A_DROME. DR PIR: A34692; A34692. DR Flybase: FBgn0000567; Eip74EF. XX RN [1] RA Martin M. E., Yang X. Y., Folk W. R. RT Expression of a 91-Kilodalton PEA3-binding protein RT is down-regulated during differentiation of F9 embryonal carcinoma cells RL Mol. Cell. Biol. 12:2213-2221 (1992). RN [2] RA Thummel C. S., Burtis K. C., Hogness D. S. RT Spatial and temporal patterns of E74 transcription RT during Drosophila development RL Cell 61:101-111 (1990). RN [3] RA Burtis K. C., Thummel C. S., Jones C. W., Karim F. D., Hogness D. S. RT The Drosophila 74EF early puff contains E74, a complex RT ecdysone-inducible gene that encodes two ets-related proteins RL Cell 61:85-99 (1990). XX // AC T00209 XX ID T00209 XX DT 15.10.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA E1A 13S protein XX OS adenovirus type 2 OC viridae; ds-DNA nonenveloped viruses; adenoviridae XX CL C0004; CC; 0.6.1.0.1.2. XX SZ 289 AA; 31.8 kDa XX SF 1 zinc finger-like motif XX FF interaction with CRE-BP1 or c-Fos may be indirect [1]; FF also shown for adenovirus type 5 XX IN T00051; ATF; human, Homo sapiens. IN T00122; c-Fos; mouse, Mus musculus. IN T00123; c-Fos; human, Homo sapiens. IN T00124; c-Fos; rat, Rattus norvegicus. IN T00125; c-Fos; chick, Gallus gallus. IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T00167; CRE-BP1; human, Homo sapiens. IN T01382; CRE-BP2; rat, Rattus norvegicus. IN T01427; p300; human, Homo sapiens. XX DR EMBL: X02996; AD5001(g). DR EMBL: J01917; HACG(g). DR SwissProt: P03254; E1A_ADE02. DR SwissProt: P03255; E1A_ADE05. DR PIR: A03824; Q2AD2. DR PIR: C03824; Q2AD5. XX RN [1] RA Maguire K., Shi X.-P., Horikoshi N., Rappaport J., Rosenberg M., Weinmann R. RT Interactions between adenovirus E1A and members of RT the AP-1 family of cellular transcription factors RL Oncogene 6:1417-1422 (1991). RN [2] RA Rikitake Y., Moran E. RT DNA-binding properties of the E1A-associated 300-Kilodalton protein RL Mol. Cell. Biol. 12:2826-2836 (1992). RN [3] RA Moran E., Mathews M. B. RT Multiple functional domains in the adenovirus E1A gene RL Cell 48:177-178 (1987). RN [4] RA Boeuf H., Reimund B., Jansen-Durr P., Kedinger C. RT Differential activation of the E2F transcription factor RT by the adenovirus EIa and EIV products in F9 cells RL Proc. Natl. Acad. Sci. USA 87:1782-1786 (1990). RN [5] RA Liu F., Green M. R. R. RT A specific member of the ATF transcription factor RT family can mediate transcription activation by the adenovirus E1a protein RL Cell 61:1217-1224 (1990). XX // AC T00210 XX ID T00210 XX DT 27.10.92 (created); ewi. DT 23.06.97 (updated); ewi. XX FA E74B XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0016; ETS; 3.5.2.0.15.2. XX SZ 883 AA; 94.8 kDa (cDNA) XX SQ MIMVQHLVAASAHNFASQAAASLVNVSSSSSSSSSSSSSSLSLSSSSSSSSLSSATPTPV SQ ASPVTPTSPPPAAAAPAEASPPAGAELQEDGQQAKTQEDPTMKDQDMLEKTRQEVKDPVN SQ VEEPGAIVDTESVMARQSPSPVASTKVPESLEEISNKSPPVQEDEEESESVASDCREFKV SQ LYNHLRQQQHHHSPSSPDKTRSTLDDVSKILWERKQQLQRSSVITAAPTLQPQQHQQPMS SQ DIEDEETLEDVDDADADVEADAEDEELLEQYQNGYDSPLDLSLGGATSAAASAAAAASAV SQ SRRRGRTYSGTESDDSAQCERARMRLKPERKAERSAAYKKSLMKRYYTEIPIVKQSTSPA SQ PQQQLQQQHHLQQQQQQQPHNGSTFAGATALLHIKTEQNTLLTPLQLQQQQQQQQGLHGA SQ AGNGGSSNGNNAHQQQQPLAIPQRPLLHNLLSGGAIHNPHHRNYTTATTGSFPPSPADSG SQ VSDVDSSSSGGQPCADELKARLGMPPATSASAAAAAAAAAAAAAHLHTGTFLHPNLYQNN SQ AANSLRNIWNRSVGVPDNYYGSSGAGSGGTQPGGPGNPQTPGYLTTSYFNAPTAATAAAS SQ QRGTTINGYHSLHQQQQQQQQSQQSQQQQQLAHQQLSHQQQQALHQQLSHQQQQQQQQQQ SQ QHPHSQLNGPHPHSHPHSHPHSHPHAGQHTHSTIAAAAAAAAASVVSSSSSAVAAAAMLS SQ ASAAAAATAAAAAGGSQSVIQPATSSVSYDLSYMLELGGFQQRKAKKPRKPKLEMGVKRR SQ SREGSTTYLWEFLLKLLQDREYCPRFIKWTNREKGVFKLVDSKAVSRLWGMHKNKPDMNY SQ ETMGRALRYYYQRGILAKVDGQRLVYHFVDVPKDIIEIDCNGV XX SC SwissProt #P11536 XX FT 27 54 serine-rich region (25/28) FT 86 131 acidic region (14/46) FT 163 177 acidic region (8/15) FT 241 269 acidic region (18/29) FT 362 437 glutamine-rich region (26/76) FT 507 524 alanine-rich region (15/18) FT 614 661 glutamine-rich region (34/48) FT 695 733 alanine-rich region (25/39) FT 790 829 tryptophan cluster (W-X18-W-X19-W) FT 1 347 replaced by 1-293 in E74A XX FF ecdysone-induced; FF expression pattern differs from that of E74A [1]; FF it peaks at 18-21 h during embryonal development, FF re-appearing at 96-120 h )late third instar larvae), FF increases again after 156 h (pupae) and reaches a FF maximum at 180-204 h, then declining sharply and being FF undetectable in adult flies [2], [1]; XX DR EMBL: X15087; DM74E(g). DR EMBL: M37083; DME74B(r). DR SwissProt: P11536; E74B_DROME. DR PIR: B34692; B34692. DR PIR: S04722; S04722. DR Flybase: FBgn0000567; Eip74EF. XX RN [1] RA Thummel C. S., Burtis K. C., Hogness D. S. RT Spatial and temporal patterns of E74 transcription RT during Drosophila development RL Cell 61:101-111 (1990). RN [2] RA Janknecht R., Taube W., Luedecke H. J., Pongs O. RT Characterization of a putative transcription Factor RT gene expressed in the 20-OH-ecdysone inducible puff RT 74EF in Drosophila melanogaster RL Nucleic Acids Res. 17:4455-4464 (1989). RN [3] RA Burtis K. C., Thummel C. S., Jones C. W., Karim F. D., Hogness D. S. RT The Drosophila 74EF early puff contains E74, a complex RT ecdysone-inducible gene that encodes two ets-related proteins RL Cell 61:85-99 (1990). XX // AC T00211 XX ID T00211 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA EBNA-1 XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX SZ 80 kDa XX SQ MSDEGPGTGPGNGLGEKGDTSGPEGSGGSGPQRRGGDNHGRGRGRGRGRGGGRPGAPGGS SQ GSGPRHRDGVRRPQKRPSCIGCKGTHGGTGAGAGAGGAGAGGAGAGGGAGAGGGAGGAGG SQ AGGAGAGGGAGAGGGAGGAGGAGAGGGAGAGGGAGGAGAGGGAGGAGGAGAGGGAGAGGG SQ AGGAGAGGGAGGAGGAGAGGGAGAGGAGGAGGAGAGGAGAGGGAGGAGGAGAGGAGAGGA SQ GAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAGGAGAGGGAGGAGAGGAGGAGAGGA SQ GGAGAGGAGGAGAGGGAGAGGAGAGGGGRGRGGSGGRGRGGSGGRGRGGSGGRRGRGRER SQ ARGGSRERARGRGRGRGEKRPRSPSSQSSSSGSPPRRPPPGRRPFFHPVGEADYFEYHQE SQ GGPDGEPDVPPGAIEQGPADDPGEGPSTGPRGQGDGGRRKKGGWFGKHRGQGGSNPKFEN SQ IAEGLRALLARSHVERTTDEGTWVAGVFVYGGSKTSLYNLRRGTALAIPQCRLTPLSRLP SQ FGMAPGPGPQPGPLRESIVCYFMVFLQTHIFAEVLKDAIKDLVMTKPAPTCNIRVTVCSF SQ DDGVDLPPWFPPMVEGAAAEGDDGDDGDEGGDGDEGEEGQE XX SC SwissProt #P03211 XX BS R01178; EBV$ORIP_01; Quality: 6; EBV, Epstein-Barr virus XX DR EMBL: M13941; HEHS4NA1(g). DR SwissProt: P03211; EBN1_EBV. DR PIR: C43043; QQBE31. XX RN [1] RA Kimball A. S., Milman G., Tullius T. D. RT High-Resolution Footprints of the DNA-Binding Domain RT of Epstein-Barr Virus Nuclear Antigen 1 RL Mol. Cell. Biol. 9:2738-2742 (1989). XX // AC T00212 XX ID T00212 XX DT 26.01.93 (created); hse. XX FA E2BP XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX FF heat-labile, acts on U3 region of the RSV-LTR XX BS R02140; E2BP$CONS; Quality: 4 XX RN [1] RA Kenny S., Guntaka R. V. RT Localization by mutational analysis of transcription RT factor binding sequences in the U3 region of Rous Sarcoma virus LTR RL Virology 176:483-493 (1990). XX // AC T00213 XX ID T00213 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); hse; ewi. XX FA EBP-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO LBP, NF-kappaB (p50) XX SZ 60 (58-63) kDa; 57-60 kDa (SDS) XX CP (HeLa) XX BS R02144; EBP1$CONS; Quality: 2 BS R00699; HIV1$HIV1_06; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R00702; HIV1$HIV1_09; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R00920; HS$IFNB_05; Quality: 6; human, Homo sapiens BS R00879; MOUSE$IGKL_03; Quality: 6; mouse, Mus musculus BS R01059; MOUSE$M1H2KB_07; Quality: 6; mouse, Mus musculus BS R01409; SV$SV40_41; Quality: 6; SV40, simian virus 40 XX RN [1] RA Clark L., Matthews J. R., Hay R. T. RT Interaction of enhancer-binding protein EBP1 (NF-kappaB) RT with the human immunodeficiency virus type 1 enhancer RL J. Virol. 64:1335-1344 (1990). RN [2] RA Wu F. K., Garcia J. A., Harrich D., Gaynor R. B. RT Purification of the human immunodeficiency virus type RT 1 enhancer and TAR binding proteins EBP-1 and UBP-1 RL EMBO J. 7:2117-2129 (1988). RN [3] RA Clark L., Hay R. T. RT Sequence requirements for specific interaction of RT an enhancer binding protein (EBP1) with DNA RL Nucleic Acids Res. 17:499-516 (1989). RN [4] RA Clark L., Pollock R. M., Hay R. T. RT Identification and purification of EBP1: a HeLa cell RT protein that binds to a region overlapping the core of the SV40 enhancer RL Genes Dev. 2:991-1002 (1988). XX // AC T00214 XX ID T00214 XX DT 15.10.92 (created); ewi. XX FA muEBP-B XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00846; MOUSE$IGH_12; Quality: 6; mouse, Mus musculus XX RN [1] RA Tsao B. P., Wang X.-F., Peterson C. L., Calame K. RT In vivo functional analysis of in vitro protein binding RT sites in the immunoglobulin heavy chain enhancer RL Nucleic Acids Res. 16:3239-3253 (1988). XX // AC T00215 XX ID T00215 XX DT 15.10.92 (created); ewi. XX FA muEBP-C2 XX SY NF-muE3; YEB3; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 42.5, 44, 45 kDa XX FF different from muEBP-E XX BS R00844; MOUSE$IGH_10; Quality: 6; mouse, Mus musculus BS R00846; MOUSE$IGH_12; Quality: 6; mouse, Mus musculus BS R00886; MOUSE$IGKL_10; Quality: 6; mouse, Mus musculus BS R01427; MOUSE$TCRB_02; Quality: 6; mouse, Mus musculus BS R01428; MOUSE$TCRB_03; Quality: 6; mouse, Mus musculus BS R02218; NFME3$CONS; Quality: 6 XX RN [1] RA McDougall S., Peterson C., Calame K. RT A transcriptional enhancer 3' of Cbeta2 in the T cell receptor beta locus RL Science 241:205-208 (1988). RN [2] RA Beckmann H., Kadesch T. RT Identification of a Yeast Protein with Properties RT Similar to Those of the Immunoglobulin Heavy-Chain RT Enhancer-Binding Protein NF-muE3 RL Mol. Cell. Biol. 9:4535-4540 (1989). RN [3] RA Peterson C. L., Calame K. RT Proteins Binding to Site C2 (muE3) in the Immunoglobulin RT Heavy-Chain Enhancer Exist in Multiple Oligomeric Forms RL Mol. Cell. Biol. 9:776-786 (1989). RN [4] RA Tsao B. P., Wang X.-F., Peterson C. L., Calame K. RT In vivo functional analysis of in vitro protein binding RT sites in the immunoglobulin heavy chain enhancer RL Nucleic Acids Res. 16:3239-3253 (1988). XX // AC T00216 XX ID T00216 XX DT 15.10.92 (created); ewi. DT 03.03.97 (updated); ewi. XX FA C/EBPgamma XX SY GPE1-BP; Ig/EBP-1; Ig/EBP1; muEBP-E; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.3.0.3. XX SZ >218 AA; 23.3 kDa (cDNA); 45 kDa (SDS,GF) XX SQ HELAGCEAWVGSGRAAPRGAARSGGRLGAGGPAGAQVHVKIFWQLSVASSDHIALISTYS SQ VLAKERAQMSKLSQPATTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAVPPSKQS SQ KKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLT SQ KELSVLKDLFLEHAHSLADNVQPISTETTATNSDNPGQ XX SC translated from EMBL #X55499 XX FT 134 154 basic region FT 158 186 leucine zipper (TL4) XX SF cDNA clone (ORF of >218 AA) was supposed to be partial SF [10], but genomic clones suggest a protein of 150 AA (16.4 kDa) [1]; SF no heterodimers with DBP [2], [10]; XX CP ubiquitous (macrophages, early B cells) [5]; XX FF transcriptional activator [6], [8]; XX IN T00017; C/EBPbeta; mouse, Mus musculus. IN T00051; ATF; human, Homo sapiens. IN T00104; C/EBPalpha; mouse, Mus musculus. IN T00105; C/EBPalpha; human, Homo sapiens. IN T00106; C/EBP; fruit fly, Drosophila melanogaster. IN T00107; C/EBPalpha; chick, Gallus gallus. IN T00108; C/EBPalpha; rat, Rattus norvegicus. IN T00109; C/EBPdelta; rat, Rattus norvegicus. IN T00216; C/EBPgamma; mouse, Mus musculus. IN T00583; C/EBPdelta; human, Homo sapiens. IN T01303; CREB-2; human, Homo sapiens. IN T01386; C/EBP; Aplysia, Aplysia californica. IN T01388; C/EBP; clawed frog, Xenopus laevis. XX BS R03906; AS$ATF_04; Quality: 6 BS R00207; AS$CEBP_01; Quality: 2 BS R02183; IGEBP1$CONS; Quality: 6 BS R00089; MOUSE$ALBU_08; Quality: 2; mouse, Mus musculus BS R00600; MOUSE$GCSF_01; Quality: 6; mouse, Mus musculus BS R00837; MOUSE$IGH_03; Quality: 2; mouse, Mus musculus BS R00840; MOUSE$IGH_06; Quality: 6; mouse, Mus musculus BS R00846; MOUSE$IGH_12; Quality: 6; mouse, Mus musculus BS R00847; MOUSE$IGH_13; Quality: 2; mouse, Mus musculus BS R00856; MOUSE$IGH_22; Quality: 6; mouse, Mus musculus BS R00880; MOUSE$IGKL_04; Quality: 6; mouse, Mus musculus BS R01426; MOUSE$TCRB_01; Quality: 6; mouse, Mus musculus BS R01427; MOUSE$TCRB_02; Quality: 6; mouse, Mus musculus BS R01428; MOUSE$TCRB_03; Quality: 6; mouse, Mus musculus BS R01358; RAT$SSTA_01; Quality: 6; rat, Rattus norvegicus BS R01344; RSV$RSV_04; Quality: 2; RSV, rous sarcoma virus XX DR EMBL: X55499; MMIGEBP1(r). XX RN [1] RA Nishizawa M., Wakabayashi-Ito N., Nagata S. RT Molecular cloning of cDNA and a cromosomal gene encoding RT GPE1-BP, a nuclear protein which binds to granulocyte RT colony-stimulating fator promoter element 1 RL FEBS Lett. 1:95-97 (1991). RN [2] RA Vinson C. R., Hai T., Boyd S. M. RT Dimerization specificity of the leucine zipper-containing RT bZIP motif on DNA binding: prediction and rational design RL Genes Dev. 7:1047-1058 (1993). RN [3] RA McDougall S., Peterson C., Calame K. RT A transcriptional enhancer 3' of Cbeta2 in the T cell receptor beta locus RL Science 241:205-208 (1988). RN [4] RA Thomassin H., Hamel D., Bernier D., Guertin M., Belanger L. RT Molecular cloning of two C/EBP-related proteins that RT bind to the promoter and the enhancer of the alpha1-fetoprotein RT gene. Further analysis of C/EBPbeta and C/EBPgamma RL Nucleic Acids Res. 20:3091- 3098 (1992). RN [5] RA Thomassin H., Hamel D., Bernier D., Guertin M., Belanger L. RT Molecular cloning of two C/EBP-related proteins that RT bind to the promoter and the enhancer of the alpha1-fetoprotein RT gene. Further analysis of C/EBP beta and C/EBPgamma RL Nucleic Acids Res. 20:3091-3098 (1992). RN [6] RA Peterson C. L., Eaton S., Calame K. RT Purified muEBP-E Binds to Immunoglobulin Enhancers and Promoters RL Mol. Cell. Biol. 8:4972-4980 (1988). RN [7] RA Peterson C. L., Calame K. RT Proteins Binding to Site C2 (muE3) in the Immunoglobulin RT Heavy-Chain Enhancer Exist in Multiple Oligomeric Forms RL Mol. Cell. Biol. 9:776-786 (1989). RN [8] RA Peterson C. L., Calame K. L. RT Complex Protein Binding within the Mouse Immunoglobulin Heavy-Chain Enhancer RL Mol. Cell. Biol. 7:4194-4203 (1987). RN [9] RA Tsao B. P., Wang X.-F., Peterson C. L., Calame K. RT In vivo functional analysis of in vitro protein binding RT sites in the immunoglobulin heavy chain enhancer RL Nucleic Acids Res. 16:3239-3253 (1988). RN [10] RA Roman C., Platero J. S., Shuman J., Clamae K. RT Ig/EBP-1: a ubiquitously expressed immunoglobulin RT enhancer binding protein that is similar to C/EBP RT and heterodimerizes with C/EBP RL Genes Dev. 4:1404-1415 (1990). XX // AC T00217 XX ID T00217 XX DT 15.10.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA EcR XX SY ecdysone receptor; ecdysterone receptor; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0002; CC (rec); 2.1.2.8.1. XX SZ 879 AA; 80-90 kDa (SDS) XX FF binding of RXR-alpha heterodimer, not of USP-heterodimer, FF is stimulated by muristerone and 9-cis-retinoic acid XX IN T00117; CF1; fruit fly, Drosophila melanogaster. IN T01331; RXR-alpha; mouse, Mus musculus. IN T01345; RXR-alpha; human, Homo sapiens. IN T01359; RXR-alpha; clawed frog, Xenopus laevis. XX BS R03988; AS$ECR_01; Quality: 2 BS R03319; DROME$HSP23_01; Quality: 6; fruit fly, Drosophila melanogaster BS R00750; DROME$HSP27_04; Quality: 6; fruit fly, Drosophila melanogaster BS R03021; ECR$CONS_01; Quality: 6 BS R03328; ECR$CONS_02; Quality: 6 XX DR EMBL: M74078; DMECR(r). DR Flybase: FBgn0000546; EcR. XX RN [1] RA Thomas H. E., Stunnenberg H. G., Stewart A. F. RT Heterodimerization of the Drosophila ecdysone receptor RT with retinoid X receptor and ultraspiracle RL Nature 362:471-475 (1993). RN [2] RA Riddihough G., Pelham H. R. B. RT An ecdysone response element in the Drosophila hsp70 promoter RL EMBO J. 6:3729-3734 (1987). RN [3] RA Cherbas L., Lee K., Cherbas P. RT Identification of ecdysone receptor elements by analysis RT of the Drosophila Eip28/29 gene RL Genes Dev. 5:120-131 (1991). RN [4] RA Luo Y., Amin J., Voellmy R. RT Ecdysterone receptor is a sequence-specific transcription RT factor involved in the developmental regulation of heat shock genes RL Mol. Cell. Biol. 11:3660-3675 (1991). XX // AC T00218 XX ID T00218 XX DT 12.03.93 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA eE-TF XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SF (C/EBP-like ?) XX CP (liver, kidney) XX BS R02968; MOUSE$ALBU_18; Quality: 6; mouse, Mus musculus XX RN [1] RA Liu J.-K., DiPersio C. M., Zaret K. S. RT Extracellular signals that regulate liver transcription RT factors during hepatic differentiation in vitro RL Mol. Cell. Biol. 11:773-784 (1991). XX // AC T00219 XX ID T00219 XX DT 15.10.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA E2F XX SY EIIF; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 430 AA; 74 kDa, 54 kDa (SDS) XX FF DNA-binding is inhibited by E7 of HPV-16 XX IN T00206; E4; adenovirus type 5. IN T01301; E4; adenovirus type 2. IN T01377; E2F-BF; mouse, Mus musculus. IN T01378; E2F-I; mouse, Mus musculus. XX MX M00024; V$E2F_01 MX M00050; V$E2F_02 XX BS R00326; AD$E2AE1_12; Quality: 6; adenovirus BS R00329; AD$E2AE1_15; Quality: 6; adenovirus BS R02141; E2F$CONS; Quality: 2 XX DR EMBL: L21973; MME2F1A(r). XX RN [1] RA Phelps W. C., Bagchi S., Barnes J. A., Raychaudhuri RA P., Kraus V., Muenger K., Howley P. M., Nevins J. R. RT Analysis of trans activation by human papilloma virus RT type 16 E7 and adenovirus 12S E1A suggests a common mechanism RL J. Virol. 65:6922-6930 (1991). RN [2] RA Raychaudhuri P., Bagchi S., Devoto S. H., Kraus V. RA B., Moran E., Nevins J. R. RT Domains of the adenovirus E1A protein required for RT oncogenic activity are also required for dissociation RT of E2F transcription factor complexes RL Genes Dev. 5:1200-1211 (1991). RN [3] RA Nevins R. RT E2F: A link between the Rb tumor suppressor protein and viral oncoproteins RL Science 258:424-429 (1992). RN [4] RA Mudryj M., Hiebert S. W., Nevins J. R. RT A role for the adenovirus inducible E2F transcription RT factor in a proliferation dependent signal transduction pathway RL EMBO J. 9:2179-2184 (1990). RN [5] RA Neill S. D., Hemstrom C., Virtanen A., Nevins J. R. RT An adenovirus E4 gene product trans-activates E2 transcription RT and stimulates stable E2F binding through a direct association with E2F RL Proc. Natl. Acad. Sci. USA 87:2008-2012 (1990). RN [6] RA Cordingley M. G., Riegel A. T., Hager G. L. RT Steroid-Dependent Interaction of Transcription Factors RT with the Inducible Promoter of Mouse Mammary Tumor Virus In Vivo RL Cell 48:261-270 (1987). RN [7] RA Bagchi S., Raychaudhuri P., Nevins J. R. RT Adenovirus E1A proteins can dissociate heteromeric RT complexes involving the E2F transcription factor: RT a novel mechanism for E1A trans-activation RL Cell 62:659-669 (1990). RN [8] RA Chellappan S. P., Hiebert S., Mudryj M., Horowitz J. M., Nevins J. R. RT The E2F transcription factor is a cellular target for the RB protein RL Cell 65:1053-1061 (1991). RN [9] RA Neill S. D., Nevins J. R. RT Genetic analysis of the adenovirus E4 6/7 trans activator: RT interaction with E2F and induction of a stable DNA-protein RT complex are critical for activity RL J. Virol. 65:5364-5373 (1991). RN [10] RA Mudryj M., Devoto S. H., Hiebert S. W., Hunter T., Pines J., Nevins J. R. RT Cell cycle regulation of the E2F transcription factor RT involves an interaction with cyclin A RL Cell 65:1243-1253 (1991). RN [11] RA Bagchi S., Weinmann R., Raychaudhuri P. RT The retinoblastoma protein copurifies with E2F-I; RT an E1A-regulated inhibitor of the transcription factor E2F RL Cell 65:1063-1072 (1991). XX // AC T00220 XX ID T00220 XX DT 26.01.93 (created); hse. DT 11.03.94 (updated); hwi. XX FA E2F XX SY EIIF; XX OS monkey, Cercopithecus aethiops OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; primates; haplorhini; OC catarrhini; cercopithecidae; cercopithecinae XX SZ 54 kDa (SDS) XX IN T00206; E4; adenovirus type 5. IN T01301; E4; adenovirus type 2. IN T01377; E2F-BF; mouse, Mus musculus. IN T01378; E2F-I; mouse, Mus musculus. XX MX M00024; V$E2F_01 XX BS R02141; E2F$CONS; Quality: 6 XX RN [1] RA Mudryj M., Hiebert S. W., Nevins J. R. RT A role for the adenovirus inducible E2F transcription RT factor in a proliferation dependent signal transduction pathway RL EMBO J. 9:2179-2184 (1990). RN [2] RA Neill S. D., Hemstrom C., Virtanen A., Nevins J. R. RT An adenovirus E4 gene product trans-activates E2 transcription RT and stimulates stable E2F binding through a direct association with E2F RL Proc. Natl. Acad. Sci. USA 87:2008-2012 (1990). RN [3] RA Bagchi S., Raychaudhuri P., Nevins J. R. RT Adenovirus E1A proteins can dissociate heteromeric RT complexes involving the E2F transcription factor: RT a novel mechanism for E1A trans-activation RL Cell 62:659-669 (1990). RN [4] RA Chellappan S. P., Hiebert S., Mudryj M., Horowitz J. M., Nevins J. R. RT The E2F transcription factor is a cellular target for the RB protein RL Cell 65:1053-1061 (1991). RN [5] RA Neill S. D., Nevins J. R. RT Genetic analysis of the adenovirus E4 6/7 trans activator: RT interaction with E2F and induction of a stable DNA-protein RT complex are critical for activity RL J. Virol. 65:5364-5373 (1991). RN [6] RA Mudryj M., Devoto S. H., Hiebert S. W., Hunter T., Pines J., Nevins J. R. RT Cell cycle regulation of the E2F transcription factor RT involves an interaction with cyclin A RL Cell 65:1243-1253 (1991). RN [7] RA Bagchi S., Weinmann R., Raychaudhuri P. RT The retinoblastoma protein copurifies with E2F-I; RT an E1A-regulated inhibitor of the transcription factor E2F RL Cell 65:1063-1072 (1991). XX // AC T00221 XX ID T00221 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA E2F XX SY EIIF; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO EIIaE-A XX CL ; ; 1.3.2.3. XX SZ 54 kDa XX SF as a DNA binding activity, E2F is generally composed SF of an E2F-family member (E2F-1, -2, -3, -4) and DP-1 SF (or a related protein) in a heterodimeric complex XX CP (HeLa) XX FF activator of myc (basal + E1A-induced activation) XX IN T00206; E4; adenovirus type 5. IN T00722; Rb; human, Homo sapiens. IN T01301; E4; adenovirus type 2. IN T01377; E2F-BF; mouse, Mus musculus. IN T01378; E2F-I; mouse, Mus musculus. IN T01486; p107; human, Homo sapiens. IN T01487; cyclin A; human, Homo sapiens. XX MX M00024; V$E2F_01 MX M00050; V$E2F_02 XX BS R00310; AD$E1A_04; Quality: 6; adenovirus type 5 BS R00311; AD$E1A_05; Quality: 6; adenovirus type 5 BS R02000; AD$E1A_24; Quality: 6; adenovirus type 5 BS R00326; AD$E2AE1_12; Quality: 6; adenovirus BS R00329; AD$E2AE1_15; Quality: 6; adenovirus BS R00330; AD$E2AE1_16; Quality: 6; adenovirus type 5 BS R03879; AD$E2AE1_24; Quality: 6; adenovirus type 2 BS R02141; E2F$CONS; Quality: 1 BS R01801; HA$DHR_01; Quality: 4; hamster, Cricetulus griseus BS R01803; HA$DHR_03; Quality: 6; hamster, Cricetulus griseus BS R01851; HS$CMYC_05; Quality: 6; human, Homo sapiens BS R01852; HS$CMYC_06; Quality: 6; human, Homo sapiens XX DR EMBL: S49592; S49592(r). DR Compel: C00121 XX RN [1] RA Nevins R. RT E2F: A link between the Rb tumor suppressor protein and viral oncoproteins RL Science 258:424-429 (1992). RN [2] RA Mudryj M., Hiebert S. W., Nevins J. R. RT A role for the adenovirus inducible E2F transcription RT factor in a proliferation dependent signal transduction pathway RL EMBO J. 9:2179-2184 (1990). RN [3] RA Boeuf H., Reimund B., Jansen-Durr P., Kedinger C. RT Differential activation of the E2F transcription factor RT by the adenovirus EIa and EIV products in F9 cells RL Proc. Natl. Acad. Sci. USA 87:1782-1786 (1990). RN [4] RA Neill S. D., Hemstrom C., Virtanen A., Nevins J. R. RT An adenovirus E4 gene product trans-activates E2 transcription RT and stimulates stable E2F binding through a direct association with E2F RL Proc. Natl. Acad. Sci. USA 87:2008-2012 (1990). RN [5] RA Kovesdi I., Reichel R., Nevins J. R. RT Role of an adenovirus E2 promoter binding factor in RT E1A-mediated coordinate gene control RL Proc. Natl. Acad. Sci. USA 84:2180-2184 (1987). RN [6] RA Jalinot P., Devaux B., Kedinger C. RT The Abundance and In Vitro DNA Binding of Three Cellular RT Proteins Interacting with the Adenovirus EIIa Early RT Promoter Are Not Modified by the EIa Gene Products RL Mol. Cell. Biol. 7:3806-3817 (1987). RN [7] RA Loeken M. R., Brady J. RT The Adenovirus EIIA Enhancer RL J. Biol. Chem. 264:6572-6579 (1989). RN [8] RA SivaRaman L., Thimmappaya B. RT Two promoter-specific host factors interact with adjacent RT sequences in an EIA-inducible adenovirus promoter RL Proc. Natl. Acad. Sci. USA 84:6112-6116 (1987). RN [9] RA Hardy S., Shenk T. RT E2F from Adenovirus-Infected Cells Binds Cooperatively RT to DNA Containing Two Properly Oriented and Spaced Recognition Sites RL Mol. Cell. Biol. 9:4495-4506 (1989). RN [10] RA Yee A. S., Reichel R., Kovesdi I., Nevins J. R. RT Promoter interaction of the E1A-inducible factor E2F RT and its potential role in the formation of a multi-component complex RL EMBO J. 6:2061-2068 (1987). RN [11] RA Blake M. C., Azizkhan J. C. RT Transcription Factor E2F Is Required for Efficient RT Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo RL Mol. Cell. Biol. 9:4994-5002 (1989). RN [12] RA Jalinot P., Wintzerith M., Gaire M., Hauss C., Egly J. M., Kedinger C. RT Purification and functional characterization of a RT cellular transcription factor that binds to an enhancer RT element within the adenovirus early EIIa promoter RL Proc. Natl. Acad. Sci. USA 85:2484-2488 (1988). RN [13] RA Yee A. S., Raychaudhuri P., Jakoi L., Nevins J. R. RT The Adenovirus-Inducible Factor E2F Stimulates Transcription RT after Specific DNA Binding RL Mol. Cell. Biol. 9:578-585 (1989). RN [14] RA Huang M.-M., Hering P. RT The adenovirus early 4 open reading frame 6/7 protein RT regulates the DNA binding activity of the cellular RT transcription factor, E2F, through a direct complex RL Genes Dev. 3:1699-1710 (1989). RN [15] RA Hiebert S. W., Lipp M., Nevins J. R. RT E1A-dependent trans-activation of the human MYC promoter RT is mediated by the E2F factor RL Proc. Natl. Acad. Sci. USA 86:3594-3598 (1989). RN [16] RA Hardy S., Engel D. A., Shenk T. RT An adenovirus early region 4 gene product is required RT for induction of the infection-specific form of cellular E2F activity RL Genes Dev. 3:1062-1074 (1989). RN [17] RA Thalmeier K., Synovzik H., Mertz R., Winnacker E.-L., Lipp M. RT Nuclear factor E2F mediates basic transcription and RT trans-activation by E1a of the human MYC promoter RL Genes Dev. 3:527-536 (1989). RN [18] RA Jansen-Durr P., Boeuf H., Kedinger C. RT Cooperative binding of two E2F molecules to an E1a-responsive RT promoter is triggered by the adenovirus E1a, but not RT by a cellular E1a-like activity RL EMBO J. 8:3365-3370 (1989). RN [19] RA Bagchi S., Raychaudhuri P., Nevins J. R. RT Adenovirus E1A proteins can dissociate heteromeric RT complexes involving the E2F transcription factor: RT a novel mechanism for E1A trans-activation RL Cell 62:659-669 (1990). RN [20] RA Chellappan S. P., Hiebert S., Mudryj M., Horowitz J. M., Nevins J. R. RT The E2F transcription factor is a cellular target for the RB protein RL Cell 65:1053-1061 (1991). RN [21] RA Neill S. D., Nevins J. R. RT Genetic analysis of the adenovirus E4 6/7 trans activator: RT interaction with E2F and induction of a stable DNA-protein RT complex are critical for activity RL J. Virol. 65:5364-5373 (1991). RN [22] RA Mudryj M., Devoto S. H., Hiebert S. W., Hunter T., Pines J., Nevins J. R. RT Cell cycle regulation of the E2F transcription factor RT involves an interaction with cyclin A RL Cell 65:1243-1253 (1991). RN [23] RA Bagchi S., Weinmann R., Raychaudhuri P. RT The retinoblastoma protein copurifies with E2F-I; RT an E1A-regulated inhibitor of the transcription factor E2F RL Cell 65:1063-1072 (1991). XX // AC T00222 XX ID T00222 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA E4F XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 50 kDa (SDS) XX SF phosphorylation XX CP (HeLa) XX FF phosphorylation activates DNA-binding; FF different from E4F1 XX BS R00355; AD$E4_09; Quality: 6; adenovirus type 2 BS R00365; AD$E4_19; Quality: 6; adenovirus type 5 BS R02142; E4F$CONS; Quality: 1 XX RN [1] RA Raychaudhuri P., Rooney R., Nevins J. R. RT Identification of an E1A-inducible cellular factor RT that interacts with regulatory sequences within the adenovirus E4 promoter RL EMBO J. 6:4073-4081 (1987). RN [2] RA Raychaudhuri P., Bagchi S., Nevins J. R. RT DNA-binding activity of the adenovirus-induced E4F RT transcription factor is regulated by phosphorylation RL Genes Dev. 3:620-627 (1989). RN [3] RA Rooney R. J., Raychaudhuri P., Nevins R. RT E4F and ATF, two transcription factors that recognize RT the same site, can be distinguished both physically RT and functionally: a role for E4F in E1A trans activation RL Mol. Cell. Biol. 10:5138-5149 (1990). RN [4] RA Leza M. A., Hearing P. RT Cellular transcription factor binds to adenovirus RT early region promoters and to a cyclic AMP response element RL J. Virol. 62:3003-3013 (1988). XX // AC T00223 XX ID T00223 XX DT 15.10.92 (created); ewi. DT 11.03.94 (updated); hwi. XX FA E4F1 XX SY E4TF3; EIIA-EF; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa, brain) XX FF different from E4F XX BS R00343; AD$E3_05; Quality: 6; adenovirus type 2 BS R00348; AD$E4_02; Quality: 6; adenovirus BS R00349; AD$E4_03; Quality: 6; adenovirus BS R00351; AD$E4_05; Quality: 6; adenovirus BS R00354; AD$E4_08; Quality: 6; adenovirus type 5 BS R00363; AD$E4_17; Quality: 6; adenovirus type 5 BS R00364; AD$E4_18; Quality: 6; adenovirus type 5 XX RN [1] RA Garcia J., Wu F., Gaynor R. RT Upstream regulatory regions required to stabilize RT binding to the TATA sequence in an adenovirus early promoter RL Nucleic Acids Res. 15:8367-8385 (1987). RN [2] RA Watanabe H., Imai T., Sharp P. A., Handa H. RT Identification of two transcription factors that bind RT to specific elements in the promoter of the adenovirus early-region 4 RL Mol. Cell. Biol. 8:1290-1300 (1988). RN [3] RA Lee K. A. W., Green M. R. RT A cellular transcription factor E4F1 interacts with RT an E1A-inducible enhancer and mediates constitutive RT enhancer function in vitro RL EMBO J. 6:1345-1353 (1987). XX // AC T00224 XX ID T00224 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA EF1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 18+19 kDa XX RN [1] RA Barnhart K. M., Kim C. G., Sheffery M. RT Purification and characterization of an erythroid RT cell-specific factor that binds the murine alpha- and beta-globin genes RL Mol. Cell. Biol. 9:2606-2614 (1989). XX // AC T00225 XX ID T00225 XX DT 26.01.93 (created); hse. DT 12.07.94 (updated); ewi. XX FA EF-1A XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO E4TF1 XX FF may be related or identical to E4TF1 XX BS R02145; EF1A$CONS; Quality: 6 XX RN [1] RA Bruder J. T., Hearing P. RT Nuclear Factor EF-1A Binds to the Adenovirus E1A Core RT Enhancer Element and to Other Transcriptional Control Regions RL Mol. Cell. Biol. 9:5143-5153 (1989). XX // AC T00226 XX ID T00226 XX DT 15.10.92 (created); ewi. DT 08.04.94 (updated); hwi. XX FA EF-1A XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R01805; AD$E1A_09; Quality: 6; adenovirus BS R01806; AD$E1A_10; Quality: 6; adenovirus BS R02145; EF1A$CONS; Quality: 2 XX RN [1] RA Bruder J. T., Hearing P. RT Nuclear Factor EF-1A Binds to the Adenovirus E1A Core RT Enhancer Element and to Other Transcriptional Control Regions RL Mol. Cell. Biol. 9:5143-5153 (1989). XX // AC T00227 XX ID T00227 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA EFgammaa XX SY EF1; Eryf-1; GF-1; NF-E1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0003; CC (g); . XX SZ 413 AA XX SQ MEFPGLGSLGTSEPLPQFVDPALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAAL SQ AYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTREDSPPQA SQ VEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPL SQ NSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRP SQ LIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKD SQ GIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGPPGT SQ AHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS XX SC SwissProt #P15976 XX CP erythroid cells XX FF down-regulated by TPA [2]; XX BS R00534; CHICK$BAG_08; Quality: 1; chick, Gallus gallus BS R00526; HS$BG_07; Quality: 6; human, Homo sapiens BS R00552; HS$GG_06; Quality: 6; human, Homo sapiens BS R00507; MOUSE$AAG_01; Quality: 6; mouse, Mus musculus BS R00544; MOUSE$BMG_05; Quality: 6; mouse, Mus musculus XX DR EMBL: X17254; HSERYF1(r). DR EMBL: M30601; HSGF1A(r). DR SwissProt: P15976; GAT1_HUMAN. DR PIR: A34888; A34888. DR PIR: S07121; S07121. XX RN [1] RA Gumucio D. L., Rood K. L., Gray T. A., Riordan M. RA F., Sartor C. I., Collins F. S. RT Nuclear Proteins That Bind the Human gamma-Globin RT Gene Promoter: Alterations in Binding Produced by RT Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin RL Mol. Cell. Biol. 8:5310-5322 (1988). RN [2] RA Mignotte V., Navarro S., Eleouet F.-F., Zon L. I., Romeo P.-H. RT The extinction of erythroid genes after tetradecanoylphorbol RT acetate treatment of erythroleukemic cells correlates RT with down-regulation of the tissue-specific factors NF-E1 and NF-E2 RL J. Biol. Chem. 265:22090-22092 (1990). XX // AC T00229 XX ID T00229 XX DT 12.03.93 (created); ewi. XX FA EF-C XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 1.3.2.3. XX CP (liver) XX BS R02146; EFC$CONS; Quality: 6 BS R00637; HBV$HBVE_08; Quality: 6; HBV, human hepatitis B virus XX RN [1] RA Trujillo M. A., Letovsky J., Maguire H. F., Lopez-Cabrera M., Siddiqui A. RT Functional analysis of a liver-specific enhancer of the hepatitis B virus RL Proc. Natl. Acad. Sci. USA 88:3797-3801 (1991). XX // AC T00230 XX ID T00230 XX DT 15.10.92 (created); ewi. DT 09.02.96 (updated); ewi. XX FA EF-C XX SY RF-X; RFX; RFX1; enhancer factor C; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO TGT3, EP protein, MDBP XX CL ; ; 1.5.1. XX SF identical with RFX1 [2]; XX FF activator; FF preferential binding to methylated sequences XX IN T00230; EF-C; human, Homo sapiens. XX BS R03409; DHBV$DHBV_01; Quality: 6; DHBV, duck hepatitis B virus BS R02146; EFC$CONS; Quality: 1 BS R00637; HBV$HBVE_08; Quality: 6; HBV, human hepatitis B virus BS R02570; HBV$HBVE_14; Quality: 6; HBV, human hepatitis B virus BS R00797; HCMV$IE1_11; Quality: 6; hCMV, human cytomegalovirus BS R03424; HCMV$IE1_28; Quality: 6; hCMV, human cytomegalovirus BS R01237; PA$PY_19; Quality: 6; Py, polyoma virus XX RN [1] RA Garcia A. D., Ostapchuk P., Hearing P. RT Methylation-dependent and -independent DNA binding of nuclear factor EF-C RL Virology 182:857-860 (1991). RN [2] RA Siegrist C. A., Durand B., Emery P., David E., Hearing P., Mach B., Reith W. RT RFX1 is identical to enhancer factor C and functions RT as a transactivator of the hepatitis B virus enhancer RL Proc. Natl. Acad. Sci. USA 90:6375-6384 (1993). RN [3] RA Ostapchuk P., Scheirle G., Hearing P. RT Binding of Nuclear Factor EF-C to a Functional Domain RT of the Hepatitis B Virus Enhancer Region RL Mol. Cell. Biol. 9:2787-2797 (1989). RN [4] RA Shaul Y., Ben-Levy R. RT Multiple nuclear proteins in liver cells are bound RT to hepatitis B virus enhancer element and its upstream sequences RL EMBO J. 6:1913-1920 (1987). XX // AC T00231 XX ID T00231 XX DT 26.01.93 (created); hse. XX FA EF-C XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R02146; EFC$CONS; Quality: 6 BS R02570; HBV$HBVE_14; Quality: 6; HBV, human hepatitis B virus BS R01237; PA$PY_19; Quality: 6; Py, polyoma virus XX RN [1] RA Ostapchuk P., Diffley J. F. X., Bruder J. T., Stillman RA B., Levine A. J., Hearing P. RT Interaction of a nuclear factor with the polyomavirus enhancer region RL Proc. Natl. Acad. Sci. USA 83:8550-8554 (1986). RN [2] RA Ostapchuk P., Scheirle G., Hearing P. RT Binding of Nuclear Factor EF-C to a Functional Domain RT of the Hepatitis B Virus Enhancer Region RL Mol. Cell. Biol. 9:2787-2797 (1989). XX // AC T00232 XX ID T00232 XX DT 15.10.92 (created); ewi. XX FA E2F+E4 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R00311; AD$E1A_05; Quality: 6; adenovirus type 5 BS R00326; AD$E2AE1_12; Quality: 6; adenovirus BS R00329; AD$E2AE1_15; Quality: 6; adenovirus XX RN [1] RA Neill S. D., Hemstrom C., Virtanen A., Nevins J. R. RT An adenovirus E4 gene product trans-activates E2 transcription RT and stimulates stable E2F binding through a direct association with E2F RL Proc. Natl. Acad. Sci. USA 87:2008-2012 (1990). RN [2] RA Huang M.-M., Hering P. RT The adenovirus early 4 open reading frame 6/7 protein RT regulates the DNA binding activity of the cellular RT transcription factor, E2F, through a direct complex RL Genes Dev. 3:1699-1710 (1989). RN [3] RA Hardy S., Engel D. A., Shenk T. RT An adenovirus early region 4 gene product is required RT for induction of the infection-specific form of cellular E2F activity RL Genes Dev. 3:1062-1074 (1989). XX // AC T00233 XX ID T00233 XX DT 26.01.93 (created); ewi. XX FA EFI XX SY EFIA; EFIB; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX BS R00506; HS$AG_01; Quality: 6; human, Homo sapiens BS R00233; MOUSE$A21COL_05; Quality: 6; mouse, Mus musculus BS R02870; MOUSE$M1H2KB_12; Quality: 6; mouse, Mus musculus BS R01343; RSV$RSV_03; Quality: 6; RSV, rous sarcoma virus XX RN [1] RA Faber M., Sealy L. RT Rous sarcoma virus enhancer factor I is a ubiquitous RT CCAAT transcription factor highly related to CBF and NF-Y RL J. Biol. Chem. 265:22243-22254 (1990). XX // AC T00234 XX ID T00234 XX DT 15.10.92 (created); ewi. XX FA EFI XX OS quail, Coturnix coturnix OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX BS R01343; RSV$RSV_03; Quality: 6; RSV, rous sarcoma virus XX RN [1] RA Sealey L., Chalkley R. RT At Least Two Nuclear Proteins Bind Specifically to RT the Rous Sarcoma Virus Long Terminal Repeat RL Mol. Cell. Biol. 7:787-798 (1987). XX // AC T00235 XX ID T00235 XX DT 26.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA EFIA XX SY DbpB (human); YB1 (human); XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0019; protamine-like; 1.8.1.0.2. XX SZ 322 AA; 35.7 kDa (cDNA); 35 kDa (SDS) XX SQ MSSEAETQQPPAAPAAALSAADTKPGSTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGT SQ VKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEA SQ ANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQA SQ QQRRPYRRRRFPPYYMRRPYARRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYR SQ PRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKE SQ TKAADSPAENSSAPEAEQGGAE XX SC SwissProt #P22568 XX FT 50 126 cold shock domain XX DR EMBL: M69138; RNCDS(r). DR EMBL: M57299; RREFIA(r). DR SwissProt: P22568; CBFX_RAT. DR PIR: A23677; A23677. XX RN [1] RA Ozer J., Faber M., Chalkley R., Sealy L. RT Isolation and characterization of a cDNA clone for RT the CCAAT transcription factor EFIA reveals a novel structural motif RL J. Biol. Chem. 265:22143-22152 (1990). XX // AC T00236 XX ID T00236 XX DT 26.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA EFIA XX SY DbpB (human); YB1 (human); XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0019; protamine-like; 1.8.1.0.2. XX SZ 321 AA; 35.8 kDa (cDNA); 43-60 kDa (SDS) XX SQ MSSEAETQPPAAPVPAAPAAAPADSKPNGGSGNGSSGLASAAPPAGGDKKVIATKVLGTV SQ KWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAA SQ NVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGAENIPEGQAQ SQ QRRPYRRRRYPPYYMRRPYGRRPQYSNPPVQGEIVEGADNQGAGEQGRPVRQNMYRGYRP SQ RFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKET SQ KTAEPPAENTSAPEAEQGGAE XX SC SwissProt #Q06066 XX IN T00236; EFIA; chick, Gallus gallus. IN T00237; EFIB; chick, Gallus gallus. XX DR EMBL: L13032; GGCSYB1(r). DR SwissProt: Q06066; YB1_CHICK. XX RN [1] RA Faber M., Sealy L. RT Rous sarcoma virus enhancer factor I is a ubiquitous RT CCAAT transcription factor highly related to CBF and NF-Y RL J. Biol. Chem. 265:22243-22254 (1990). XX // AC T00237 XX ID T00237 XX DT 26.01.93 (created); ewi. XX FA EFIB XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX SZ 41-48 kDa (SDS) XX IN T00236; EFIA; chick, Gallus gallus. XX RN [1] RA Faber M., Sealy L. RT Rous sarcoma virus enhancer factor I is a ubiquitous RT CCAAT transcription factor highly related to CBF and NF-Y RL J. Biol. Chem. 265:22243-22254 (1990). XX // AC T00238 XX ID T00238 XX DT 15.10.92 (created); ewi. XX FA EFII XX OS quail, Coturnix coturnix OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX BS R01342; RSV$RSV_02; Quality: 6; RSV, rous sarcoma virus XX RN [1] RA Sealey L., Chalkley R. RT At Least Two Nuclear Proteins Bind Specifically to RT the Rous Sarcoma Virus Long Terminal Repeat RL Mol. Cell. Biol. 7:787-798 (1987). XX // AC T00239 XX ID T00239 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA EFII XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX HO C/EBP XX BS R01826; ALV$LTR_01; Quality: 6; ALV, avian leukosis virus BS R01825; ALV$LTR_02; Quality: 6; ALV, avian leukosis virus BS R01824; ALV$LTR_06; Quality: 6; ALV, avian leukosis virus XX // AC T00240 XX ID T00240 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA EFII XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX SQ MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTR SQ KDEQERCITIKSTAISLFYELSENDLNFIKQSKDGSGFLINLIDSPGHVDFSSEVTAALR SQ VTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQR SQ IVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKG SQ EGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSANSPDGKKLPRTFCQLILDPIFKV SQ FDAIMNFRKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPS SQ PVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGV SQ VSTGLKVRIMGPNYTPGKKEELYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLV SQ KTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEE SQ SGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHN SQ RLYMKARPFPDGLAEDIDKGEVSARQELKARARYLAEKYEWDVAEARKIWCFGPDGTGPN SQ ILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQ SQ IIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTP SQ MFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRK SQ RKGLKEGIPALDNFLDKL XX SC SwissProt #P05086 XX BS R01347; RSV$RSV_07; Quality: 6; RSV, rous sarcoma virus XX DR EMBL: M13708; MAEF2(r). DR SwissProt: P05086; EF2_MESAU. DR PIR: A25440; A25440. XX RN [1] RA Karnitz L., Faber S., Chalkley R. RT Specific nuclear proteins interact with the Rous sarcoma RT virus internal enhancer and share a common element RT with the enhancer located in the long terminal repeat of the virus RL Nucleic Acids Res. 15:9841-9859 (1987). XX // AC T00241 XX ID T00241 XX DT 09.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA EGR1 XX SY 225; ETR103; Egr-1; Krox-24; NGFI-A; zif268; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; 2.3.2.1.2. XX SZ 543 AA XX SQ MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGS SQ NSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETS SQ YPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAAS SQ SASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAY SQ PAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSG SQ SQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIR SQ IHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLR SQ QKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSS SQ TYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTI SQ EIC XX SC SwissProt #P18146 XX SF 3 zinc finger motifs SF S/G SF S/P XX CP T-cells XX FF transiently expressed after mitogenic stimulation; FF constitutively expressed after infection with HTLV-I or HTLV-II XX MX M00243; V$EGR1_01 XX DR EMBL: X52541; HSEGR1(r). DR EMBL: M62829; HSETR103(r). DR EMBL: M80583; HSZINFING(r). DR SwissProt: P18146; EGR1_HUMAN. DR PIR: A41211; A41211. XX RN [1] RA Wright J. J., Gunter K. C., Mitsuya H., Irving St. RA G., Kelly K., Siebenlist U. RT Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells RL Science 248:588-591 (1990). XX // AC T00242 XX ID T00242 XX DT 01.12.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA EGR2 XX SY Krox-20 (mouse); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; 2.3.2.1.3. XX SZ 406 AA; 43 kDa (SDS) XX SQ MNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPE SQ GIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPP SQ PPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFF SQ PSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGMTGPGASGGSE SQ GPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRR SQ FSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARS SQ DERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQAWGYPVQQ XX SC SwissProt #P11161 XX SF 3 zinc finger motifs XX FF early growth response gene product XX MX M00246; V$EGR2_01 XX BS R02148; EGR2$CONS; Quality: 1 XX DR EMBL: J04076; HSEGR2A(r). DR SwissProt: P11161; EGR2_HUMAN. XX RN [1] RA Chavrier P., Vesque C., Galliot B., Vigneron M., Dolle RA P., Duboule D., Charnay P. RT The segment-specific gene Krox-20 encodes a transcription RT factor with binding sites in the promoter region of the Hox-1.4 gene RL EMBO J. 9:1209-1219 (1990). RN [2] RA Joseph L. J., Le Beau M. M., Jamieson G. A., Acharya RA S., Shows T. B., Rowley J. D., Sukhatme V. P. RT Molecular cloning, sequencing, and mapping of EGR2, RT a human early growth response gene encoding a protein RT with zinc-binding finger structure RL Proc. Natl. Acad. Sci. USA 85:7164-7168 (1988). XX // AC T00243 XX ID T00243 XX DT 09.11.92 (created); ewi. DT 27.08.96 (updated); ewi. XX FA EGR3 XX SY pilot; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; 2.3.2.1.4. XX SZ 387 AA; 42.6 kDa (cDNA) XX SQ MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVVHYNQMATENVMDIGLT SQ NEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGAL SQ STQTSTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDYQSAK SQ PALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIH SQ PGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHT SQ GHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKE SQ KKAEKGGAPSASSAPPVSLAPVVTTCA XX SC SwissProt #Q06889 XX SF 3 zinc finger motifs XX FF activator; FF same binding site as Egr-1 and EGR2 XX MX M00245; V$EGR3_01 XX BS R02147; EGR1$CONS; Quality: 6 XX DR EMBL: X63741; HSPILMRNA(r). DR EMBL: S40832; S40832(r). DR SwissProt: Q06889; EGR3_HUMAN. DR PIR: S19885; S19885. DR Compel: C00032 XX RN [1] RA Patwardhan S., Gashler A., Siegel M. G., Chang L. RA C., Joseph L. J., Shows Th. B., Le Beau M. M., Sukhatme V. P. RT EGR3, a novel member of the Egr family of genes encoding RT immediate-early transcription factors RL Oncogene 6:917-928 (1991). XX // AC T00244 XX ID T00244 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Egr-1 XX SY EGR1; Krox-24; NGFI-A; TIS-8; zif268; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; 2.3.2.1.2. XX SZ 533 AA; 54 kDa (cDNA); 54,84 kDa (SDS) XX SQ MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGTPEGSGG SQ NSSSSTSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKAMVETSYPS SQ QTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSS SQ SASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPA SQ TKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQ SQ DLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIH SQ TGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQK SQ DKKADKSVVASPAASSLSSYPSPVATSYPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGF SQ PSPSVATTFASVPPAFPTQVSSFPSAGVSSSFSTSTGLSDMTATFSPRTIEIC XX SC SwissProt #P08046 XX SF 3 zinc finger motifs XX FF two subunits, encoded by an immediate-early response FF gene, involved in signal transduction XX MX M00243; V$EGR1_01 XX BS R02147; EGR1$CONS; Quality: 2 BS R03721; MOUSE$ADA_01; Quality: 6; mouse, Mus musculus BS R01614; MOUSE$EGR1_01; Quality: 6; mouse, Mus musculus BS R01615; MOUSE$EGR1_02; Quality: 6; mouse, Mus musculus BS R01616; MOUSE$EGR1_03; Quality: 6; mouse, Mus musculus XX DR EMBL: M20157; MMEGR101(r). DR EMBL: M28844; MMKROX2S1(g). DR EMBL: M28845; MMKROX2S2(g). DR EMBL: M22326; MMTFEZIF(r). DR SwissProt: P08046; EGR1_MOUSE. DR PIR: A29883; A29883. DR PIR: A32065; A32065. DR PIR: JS0304; JS0304. XX RN [1] RA Cao X., Koski R. A., Gashler A., McKiernan M., Morris RA C. F., Gaffney R., Hay R. V., Sukhatme V. P. RT Identfication and characterization of the Egr-1 gene RT product, a DNA-binding zinc finger protein induced RT by differentiation and growth signals RL Mol. Cell. Biol. 10:1931-1939 (1990). RN [2] RA Lemaire P., Vesque C., Schmitt J., Stunnenberg H., Frank R., Charnay P. RT The serum-inducible mouse gene Krox-24 encodes a sequence-specific RT transcriptional activator RL Mol. Cell. Biol. 10:3456-3467 (1990). RN [3] RA Christy B., Nathans D. RT DNA binding site of the growth factor-inducible protein Zif268 RL Proc. Natl. Acad. Sci. USA 86:8737-8741 (1989). RN [4] RA Suva L. J., Ernst M., Rodan G. A. RT Retinoic acid increases zif268 early gene expression RT in rat preosteoblastic cells RL Mol. Cell. Biol. 11:2503-2510 (1991). RN [5] RA Milbrandt J. RT A nerve-growth factor-induced gene encodes a possible RT transcriptional regulatory factor RL Science 238:797-799 (1987). RN [6] RA Day M. L., Fahrner T. J., Ayken S., Milbrandt J. RT The zinc finger protein NGFI-A exists in both nuclear RT and cytoplasmic forms in nerve growth factor-stimulated PC12 cells RL J. Biol. Chem. 265:15253-15260 (1990). XX // AC T00245 XX ID T00245 XX DT 14.12.92 (created); ewi. XX FA eH-TF XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP liver XX FF essential activator for albumin gene expression XX BS R02971; MOUSE$ALBU_21; Quality: 6; mouse, Mus musculus XX RN [1] RA Mizuguchi G., Nakagoshi H., Nagase T., Nomura N., Date T., Ueno Y., Ishii S. RT DNA Binding Activity and Transcriptional Activator RT Function of the Human B-myb Protein Compared with c-MYB RL J. Biol. Chem. 265:9280-9284 (1990). RN [2] RA Liu J.-K., DiPersio C. M., Zaret K. S. RT Extracellular signals that regulate liver transcription RT factors during hepatic differentiation in vitro RL Mol. Cell. Biol. 11:773-784 (1991). XX // AC T00246 XX ID T00246 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA EIIaE-A XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO E2F XX CP (HeLa) XX BS R00327; AD$E2AE1_13; Quality: 6; adenovirus type 2 BS R03037; HS$DPOLA_02; Quality: 6; human, Homo sapiens BS R00282; MOUSE$DHFR_02; Quality: 6; mouse, Mus musculus XX RN [1] RA Jalinot P., Devaux B., Kedinger C. RT The Abundance and In Vitro DNA Binding of Three Cellular RT Proteins Interacting with the Adenovirus EIIa Early RT Promoter Are Not Modified by the EIa Gene Products RL Mol. Cell. Biol. 7:3806-3817 (1987). XX // AC T00247 XX ID T00247 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA EIIaE-B XX SY EIIA-EF; EPF; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO ATF/CREB, 47-kDa-protein XX SZ 40-43 kDa XX CP (HeLa) XX BS R00323; AD$E2AE1_08; Quality: 6; adenovirus type 5 BS R00324; AD$E2AE1_10; Quality: 6; adenovirus type 2 XX RN [1] RA Jalinot P., Devaux B., Kedinger C. RT The Abundance and In Vitro DNA Binding of Three Cellular RT Proteins Interacting with the Adenovirus EIIa Early RT Promoter Are Not Modified by the EIa Gene Products RL Mol. Cell. Biol. 7:3806-3817 (1987). RN [2] RA SivaRaman L., Subramanian S., Thimmappaya B. RT Identification of a factor in HeLa cells specific RT for an upstream transcriptional control sequence of RT an EIA-inducible adenovirus promoter and its relative RT abundance in infected and uninfected cells RL Proc. Natl. Acad. Sci. USA 83:5914-5918 (1986). RN [3] RA SivaRaman L., Thimmappaya B. RT Two promoter-specific host factors interact with adjacent RT sequences in an EIA-inducible adenovirus promoter RL Proc. Natl. Acad. Sci. USA 84:6112-6116 (1987). RN [4] RA Yee A. S., Reichel R., Kovesdi I., Nevins J. R. RT Promoter interaction of the E1A-inducible factor E2F RT and its potential role in the formation of a multi-component complex RL EMBO J. 6:2061-2068 (1987). RN [5] RA Jalinot P., Wintzerith M., Gaire M., Hauss C., Egly J. M., Kedinger C. RT Purification and functional characterization of a RT cellular transcription factor that binds to an enhancer RT element within the adenovirus early EIIa promoter RL Proc. Natl. Acad. Sci. USA 85:2484-2488 (1988). XX // AC T00248 XX ID T00248 XX DT 15.10.92 (created); ewi. XX FA EIIaE-Calpha XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R00317; AD$E2AE1_02; Quality: 6; adenovirus type 2 XX RN [1] RA Jalinot P., Devaux B., Kedinger C. RT The Abundance and In Vitro DNA Binding of Three Cellular RT Proteins Interacting with the Adenovirus EIIa Early RT Promoter Are Not Modified by the EIa Gene Products RL Mol. Cell. Biol. 7:3806-3817 (1987). XX // AC T00249 XX ID T00249 XX DT 15.10.92 (created); ewi. XX FA EIIaE-Cbeta XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R00318; AD$E2AE1_03; Quality: 6; adenovirus type 2 XX RN [1] RA Jalinot P., Devaux B., Kedinger C. RT The Abundance and In Vitro DNA Binding of Three Cellular RT Proteins Interacting with the Adenovirus EIIa Early RT Promoter Are Not Modified by the EIa Gene Products RL Mol. Cell. Biol. 7:3806-3817 (1987). XX // AC T00250 XX ID T00250 XX DT 26.10.92 (created); ewi. DT 21.05.97 (updated); ewi. XX FA Elk-1 XX SY TCF; p62TCF; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0016; ETS; 3.5.2.0.5. XX SZ 428 AA; 44.9 kDa (gene); 58 kDa (SDS) [8]; XX SQ MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKL SQ SRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIH SQ AAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVV SQ LPNAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGL SQ GRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGH SQ AASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTH SQ TLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVV SQ LSPGPQKP XX SC SwissProt #P19419 XX FT 324 324 serine-phosphorylation by MAP kinase(-like) FT activity (ERK1, ERK2) [7]; FT 336 336 threonine-phosphorylation by MAP FT kinase(-like) activity (ERK1, ERK2) [7]; FT 3 86 ETS domain (TCF homology box A) FT 137 169 essential for ternary complex formation with SRF [10], [5]; FT 307 428 regulated trans-activation domain [2], [9]; FT 351 399 homology box C FT 8 46 tryptophan cluster (W-X17-W-X19-W) FT 148 168 Box B, conserved between Elk-1, SAP-1 and SAP-2 [14]; FT 383 383 serine-phosphorylation by MAP kinase(-like) FT activity (ERK1, ERK2) [7]; FT 389 389 serine-phosphorylation by MAP kinase(-like) FT activity (ERK1, ERK2) [7]; FT 422 422 serine-phosphorylation by MAP kinase(-like) FT activity (ERK1, ERK2) [7]; XX SF CD, NMR, fluorescence: DNA-binding domain is an independently SF folded domain of alpha-helices and beta-sheet elements, SF the 3 conserved Trp being part of a hydrophobic core [3]; SF high DNA-binding affinity (Kd = 85 pM) and specificity [3]; SF no significant bending induced [3]; SF trans-activating domain within the C-terminal part SF of the molecule [2], [9] with particular importance of Phe-378 and W379 [6]; SF chromosomal location of the gene is near a breakpoint SF found in synovial sarcomas leading to the translocation t(X SF 18)(p11.2 SF q11.2) [8]; XX CP lung, testis XX FF activator [13], [9]; FF may cooperate with SRF or MCM1 on some promoters [13], [9]; FF ternary complex formation with SRE and SRF is independent FF of orientation and distance to the SRF site; FF growth factor-dependent phosphorylation in vivo at FF MAP kinase in vitro sites enhances transcriptional FF activation by Elk-1 [4], [2], [9], [6], [7]; FF downstream target of Raf-1 [4]; XX IN T00672; p67; human, Homo sapiens. IN T00761; SRF; chick, Gallus gallus. IN T00762; SRF; cat, Felis catus. IN T00763; SRF; clawed frog, Xenopus laevis. IN T00764; SRF; human, Homo sapiens. IN T00765; SRF; mouse, Mus musculus. IN T00766; SRF; rat, Rattus norvegicus. XX MX M00007; V$ELK1_01 MX M00025; V$ELK1_02 XX BS R03592; AS$ELK1_01; Quality: 6 BS R03593; AS$ELK1_02; Quality: 6 BS R03594; AS$ELK1_03; Quality: 6 BS R03595; AS$ELK1_04; Quality: 6 BS R03596; AS$ELK1_05; Quality: 6 BS R03597; AS$ELK1_06; Quality: 6 BS R03598; AS$ELK1_07; Quality: 6 BS R03599; AS$ELK1_08; Quality: 6 BS R03600; AS$ELK1_09; Quality: 6 BS R03601; AS$ELK1_10; Quality: 6 BS R03602; AS$ELK1_11; Quality: 6 BS R03603; AS$ELK1_12; Quality: 6 BS R03604; AS$ELK1_13; Quality: 6 BS R03591; ELK1$CONS_01; Quality: 6 BS R00040; HS$BAC_04; Quality: 6; human, Homo sapiens BS R00466; HS$CFOS_09; Quality: 6; human, Homo sapiens BS R00961; MOUSE$KROX_01; Quality: 6; mouse, Mus musculus BS R01155; MSV$MSV_03; Quality: 2; MSV, murine sarcoma virus BS R01224; PA$PY_06; Quality: 6; Py, polyoma virus BS R03582; XENLA$CFOS_01; Quality: 6; clawed frog, Xenopus laevis XX DR EMBL: M25269; HSELK1A(g). DR SwissProt: P19419; ELK1_HUMAN. DR PIR: A41354; TVHUEK. DR Compel: C00022 DR Compel: C00127 XX RN [1] RA Treisman R., Marais R., Wynne J. RT Spatial flexibility in ternary complexes between SRF RT and its accessory proteins RL EMBO J. 11:4631-4640 (1992). RN [2] RA Marais R., Wynne J., Treisman R. RT The SRF accessory protein Elk-1 contains a growth RT factor-regulated transcriptional activation domain RL Cell 73:381-393 (1993). RN [3] RA Shore P., Bisset L., Lakey J., Waltho J. P., Virden R., Sharrocks A. D. RT Characterization of the Elk-1 ETS DNA-binding domain RL J. Biol. Chem. 270:5805-5811 (1995). RN [4] RA Janknecht R., Ernst W. H., Pingoud V., Nordheim A. RT Acitvation of ternary complex factor Elk-1 by MAP kinases RL EMBO J. 12:5097-5104 (1993). RN [5] RA Shore P., Sharrocks A. D. RT The transcriptional factors Elk-1 and serum response RT factor interact by direct protein-protein contacts RT mediated by a short region of Elk-1 RL Mol. Cell. Biol. 14:3283-3291 (1994). RN [6] RA Price M. A., Rogers A. E., Treisman R. RT Comparative analysis of the ternary complex factors RT Elk-1, SAP-1a and SAP-2 (ERP/NET) RL EMBO J. 14:2589-2601 (1995). RN [7] RA Gille H., Kortenjann M., Thomae O., Moomaw C., Slaughter RA C., Cobb M. H., Shaw P. E. RT ERK phosphorylation potentiates Elk-1-mediated ternary RT complex formation and transactivation RL EMBO J. 14:951-962 (1995). RN [8] RA Rao V. N., Huebner K., Isobe M., Ar-rushdi A., Croce C. M., Reddy E. S. RT elk, tissue-specific ets-related genes on chromosomes RT X and 14 near translocation breakpoints RL Science 244:66-70 (1989). RN [9] RA Hill C. S., Marais R., John S., Wynne J., Dalton S., Treisman R. RT Functional analysis of a growth factor-responsive RT transcription factor complex RL Cell 73:395-406 (1993). RN [10] RA Janknecht R., Nordheim A. RT Elk-1 protein domains required for direct and SRF-assisted DNA-binding RL Nucleic Acids Res. 20:3317-3324 (1992). RN [11] RA Shaw P. E., Schroeter H., Nordheim A. RT The Ability of a Ternary Complex to Form Over the RT Serum Response Element Correlates with Serum Inducibility RT of the Human c-fos Promoter RL Cell 56:563-572 (1989). RN [12] RA Schroeter H., Mueller C. G. F., Meese K., Nordheim A. RT Synergism in ternary complex formation between the RT dimeric glycoprotein p67SRF, polypeptide p62TCF and RT the c-fos serum response element RL EMBO J. 9:1123-1130 (1990). RN [13] RA Hipskind R. A., Rao V. N., Mueller C. G. F., Reddy E. S. P., Nordheim A. RT Ets-related protein Elk-1 is homologous to the c-fos RT regulatory factor p62TCF RL Nature 354:531-534 (1991). RN [14] RA Dalton S., Treisman R. RT Characterization of SAP-1, a protein recruited by RT serum response factor to the c-fos serum response element RL Cell 68:597-612 (1992). RN [15] RA Rao V. N., Reddy E. Sh. P. RT A divergent ets-related protein, Elk-1, recognizes RT similar c-ets-1 proto-oncogene target sequences and RT acts as a transcriptional activator RL Oncogene 7:65-70 (1992). XX // AC T00251 XX ID T00251 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA ELP XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO FTZ-Z1 XX CL C0002; CC (rec); . XX SZ 465 AA; 51.3 kDa (cDNA) XX SQ MEMHRIRGSRIGRGRGGEEAALERGGWLSCSAGTWPTNPRTRPGLGTAPCAQTRAIPSQS SQ PSARADPILLPQADAAGMDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQN SQ NKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDR SQ ALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGD SQ IGAPSLPMSVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPN SQ VPELILQLLQLEPEEDQVRARIVGCLQEPAKSGSDQPAPFSLLCRMADQTFISIVDWARR SQ CMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVSGQEVTELVKPLVLHN SQ PRPLRADSGHPKFQIQGHALARLLCVLGPFEEPQCGMVSGSSYRR XX SC SwissProt #P33242 XX FT 90 158 zinc finger region FT 344 386 putative ligand binding domain XX CP (undiff. ECA2 or F9 cells) XX FF transcriptional repressor; FF binding activity disappears upon differentiation induced FF by retinoic acid (RA) XX BS R02149; ELP$CONS; Quality: 1 BS R01790; MOMLV$MOMULV_17; Quality: 1; Mo-MuLV, moloney murine leukemia virus XX DR EMBL: D10584; MMELP(r). DR SwissProt: P33242; ELP_MOUSE. DR PIR: A42128; A42128. XX RN [1] RA Tsukiyama T., Niwa O., Yokoro K. RT Analysis of the binding proteins and activity of the RT long terminal repeat of Moloney murine leukemia virus RT during differentiation of mouse embryonal carcinoma cells RL J. Virol. 65:2979-2986 (1991). RN [2] RA Tsukiyama T., Ueda H., Hirose S., Niwa O. RT Embryonal long terminal repeat-binding protein is RT a murine homolog of FTZ-F1, a member of the steroid receptor superfamily RL Mol. Cell. Biol. 12:1286-1291 (1992). RN [3] RA Tsukiyama T., Niwa O., Yokoro K. RT Mechanism of Suppression of the Long Terminal Repeat RT of Moloney Leukemia Virus in Mouse Embryonal Carcinoma Cells RL Mol. Cell. Biol. 9:4670-4676 (1989). XX // AC T00252 XX ID T00252 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA embryo DNA binding protein XX OS soybean, Glycine max OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC rosidae; fabales; fabaceae XX SZ 60 kDa XX RN [1] RA Jofuku K. D., Okamuro J. K., Goldberg R. B. RT Interaction of an embryo DNA binding protein with RT a soybean lectin gene upstream region RL Nature 328:734-737 (1987). XX // AC T00253 XX ID T00253 XX DT 15.10.92 (created); ewi. DT 16.12.96 (updated); ewi. XX FA En XX SY Engrailed; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX HO En-1, En-2 (vertebrates) XX CL C0006; homeo; 3.1.1.7.1. XX SZ 552 AA; 59.4 kDa (cDNA), 69 kDa (SDS) XX SQ MALEDRCSPQSAPSPITLQMQHLHHQQQQQQQQQQQMQHLHQLQQLQQLHQQQLAAGVFH SQ HPAMAFDAAAAAAAAAAAAAAHAHAAALQQRLSGSGSPASCSTPASSTPLTIKEEESDSV SQ IGDMSFHNQTHTTNEEEEAEEDDDIDVDVDDTSAGGRLPPPAHQQQSTAKPSLAFSISNI SQ LSDRFGDVQKPGKSIENQASIFRPFEANRSQTATPSAFTRVDLLEFSRQQQAAAAAATAA SQ MMLERANFLNCFNPAAYPRIHEEIVQSRLRRSAANAVIPPPMSSKMSDANPEKSALGSLC SQ KAVSQIGQPAAPTMTQPPLSSSASSLASPPPASNASTISSTSSVATSSSSSSSGCSSAAS SQ SLNSSPSSRLGASGSGVNASSPQPQPIPPPSAVSRDSGMESSDDTRSETGSTTTEGGKNE SQ MWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLT SQ ERRRQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEE SQ EELEMRMNGQIP XX SC SwissProt #P02836 XX FT 19 53 glutamine-rich region (22/35) FT 55 87 alanine-rich region (22/33) FT 232 240 alanine-rich region (8/9) FT 454 513 homeo domain XX SF specific DNA-binding through the homeo domain [16]; SF overlapping DNA-binding specificity with Ftz [5], [17], [16]; SF cooperative DNA-binding with Exd [4]; SF crystal structure (co-crystals with DNA): three alpha-helices, SF helix 3 operating as DNA recognition helix binding to the major groove [18]; SF conserved residues W501 and F502 are part of a hydrophobic SF core between the backs of the nearly perpendicularly SF arranged helices 3 and 1 [18]; SF 8 AA N-terminal to helix 1 bind to the minor groove [18]; SF transferable Ala-rich repressor domain of 55 AA [21], [7]; SF En may also possess activating domains [7]; XX FF active repressor; FF segment polarity gene [2], [21]; FF also competing with TFIID for TATA-binding, thereby FF repressing transcription [19]; FF for gene repression, it depends on the simultaneous FF presence of transcription activators [7]; FF expression is initially activated by pair-rule gene FF products (e. g., Ftz, Prd, Zen) which may act synergistically FF [12], [13], [10]; FF probably through an indirect mechanism, En activates FF its own transcription [3]; FF subsequently, the gene wingless (wg) encodes a signalling FF molecule in neighbouring cells which is required for FF maintenance of en expression giving rise to a positive FF autoregulation of En [11]; FF later, autoregulation becomes wg-independent [11]; XX IN T01482; Exd; fruit fly, Drosophila melanogaster. XX BS R00998; AD$MLP_13; Quality: 2; adenovirus BS R01670; AS$EN_01; Quality: 2 BS R02483; AS$EN_02; Quality: 6; fruit fly, Drosophila melanogaster BS R00411; DROME$EN_01; Quality: 2; fruit fly, Drosophila melanogaster BS R00412; DROME$EN_02; Quality: 2; fruit fly, Drosophila melanogaster BS R00414; DROME$EN_04; Quality: 6; fruit fly, Drosophila melanogaster BS R01781; DROME$EN_05; Quality: 6; fruit fly, Drosophila melanogaster BS R01782; DROME$EN_06; Quality: 6; fruit fly, Drosophila melanogaster BS R01783; DROME$EN_07; Quality: 6; fruit fly, Drosophila melanogaster BS R00757; DROME$HSP70_07; Quality: 2; fruit fly, Drosophila melanogaster BS R01528; DROME$UBX_13; Quality: 1; fruit fly, Drosophila melanogaster BS R01529; DROME$UBX_14; Quality: 6; fruit fly, Drosophila melanogaster BS R01784; DROVI$EN_01; Quality: 6; fruit fly, Drosophila virilis BS R01785; DROVI$EN_02; Quality: 6; fruit fly, Drosophila virilis BS R01786; DROVI$EN_03; Quality: 6; fruit fly, Drosophila virilis BS R02507; EN$CONS; Quality: 6 XX DR EMBL: M29285; DMENG(g). DR EMBL: K03055; DMENG1(g). DR EMBL: K03056; DMENG2(g). DR EMBL: K03057; DMENG3(g). DR EMBL: K03058; DMENG4(g). DR EMBL: M10017; DMENGM(r). DR SwissProt: P02836; HMEN_DROME. DR PIR: A03321; WJFFEN. DR Flybase: FBgn0000577; en. DR PDB: 1enh; ENGRAILED HOMEODOMAIN D. MELANOGASTER. DR PDB: 1hdd; ENGRAILED HOMEODOMAIN COMPLEX WITH DNA D. MELANOGASTER. XX RN [1] RA Biggin M. D., Tjian R. RT Transcription factors that activate the Ultrabithorax RT promoter in developmentally staged extracts RL Cell 53:699-711 (1988). RN [2] RA Ohkuma Y., Horikoshi M., Roeder R. G., Desplan C. RT Binding site-dependent direct activation and repression RT of in vitro transcription by Drosophila homeodomain proteins RL Cell 61:475-484 (1990). RN [3] RA Kassis J. A., Desplan C., Wright D. K., O'Farrell P. H. RT Evolutionary Conservation of Homeodomain-Binding Sites RT and Other Sequences Upstream and within the Major RT Transcription Unit of the Drosophila Segmentation Gene engrailed RL Mol. Cell. Biol. 9:4304-4311 (1989). RN [4] RA Van Dijk M. A., Murre C. RT extradenticle raises the DNA binding specificity of RT homeotic selector gene products RL Cell 78:617-624 (1994). RN [5] RA Desplan C., Theis J., Farrell P. H. RT The Drosophila development gene engrailed encodes RT a sequence specific DNA-binding activity RL Nature 318:630-835 (1985). RN [6] RA Poole S. J., Kauvar L. M., Drees B., Kornberg T. RT The engrailed locus of Drosophila: Structural analysis RT of an embryonic transcript. RL Cell 40:37-43 (1985). RN [7] RA Han K., Manley J. L. RT Functional domains of the Drosophila Engrailed protein RL EMBO J. 12:2723-2733 (1993). RN [8] RA DiNardo S., Kuner J., Theis J., Farrell P. H. RT Development of embryonic pattern in D. melanogaster RT as revealed by accumulation of the nuclear engrailed protein RL Cell 43:59-69 (1985). RN [9] RA Weir M. P., Kornberg T. RT Patterns of engrailed and fushi tarazu transcripts RT reveal novel intermediate stages in Drosophila segmentation RL Nature 318:433-439 (1985). RN [10] RA Han K., Levine M. S., Manley J. L. RT Synergistic activation and repression of transcription RT by Drosophila homeobox proteins RL Cell 56:573-583 (1989). RN [11] RA Heemskerk J., DiNardo S., Kostriken R., Farrell P. H. RT Multiple modes of engrailed regulation in the progression RT towards cell fate determination RL Nature 352:404-410 (1991). RN [12] RA DiNardo S., Farrell P. H. RT Establishment and refinement of segmental pattern RT in the Drosophila embryo: spatial control of engrailed RT expression by pair rule genes RL Genes Dev. 1:1212-1225 (1987). RN [13] RA Howard K., Ingham P. RT Regulatory interactions between the segmentation genes RT fushi tarazu, hairy and engrailed in the Drosophila blastoderm RL Cell 44:949-957 (1986). RN [14] RA Siegfried E., Chou T. -B., Perrimon N. RT wingless siganlling acts through zeste-white 3, the RT Drosophila homolog of glycogen synthase kinase-3, RT to regulate engrailed and establish cell fate RL Cell 71:1167-1179 (1992). RN [15] RA Fjose A., McGinnis W., Gehring W. J. RT Isolation of a homoeo box-containing gene from the RT engrailed region of Drosophila and the spatial distribution RT of its transcripts RL Nature 313:284-289 (1985). RN [16] RA Desplan C., Theis J., O'Farrell P. H. RT The sequence specificity of homeodomain-DNA interaction RL Cell 54:1081-1090 (1988). RN [17] RA Fainsod A., Bogarad L. D., Ruusala T., Lubin M., Crothers RA D. M., Ruddle F. H. RT The homeo domain of a murine protein binds 5' to its own homeo box RL Proc. Natl. Acad. Sci. USA 83:9532-9536 (1986). RN [18] RA Kissinger C. R., Liu B., Martin-Blanco E., Kornberg T. B., Pabo C. O. RT Crystal structure of an engrailed homeodomain-DNA RT complex at 2.8 A resolution: a framework for understanding RT homeodomain-DNA interactions RL Cell 63:579-590 (1990). RN [19] RA Ohkuma Y., Horikoshi M., Roeder R. G., Desplan C. RT Engrailed, a homeodomain protein, can repress in vitro RT transcription by competition with the TATA box-binding RT protein transcription factor IID RL Proc. Natl. Acad. Sci. USA 87:2289-2293 (1990). RN [20] RA Patel N. H., Ball E. E., Goodman C. S. RT Changing role of even-skipped during the evolution RT of insect pattern formation RL Nature 357:339-342 (1992). RN [21] RA Jaynes J. B., O'Farrell P. H. RT Active repression of transcription by the Engrailed homeodomain protein RL EMBO J. 10:1427-1433 (1991). XX // AC T00254 XX ID T00254 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA ENH-bind. prot. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO EP XX RN [1] RA Karpen S., Banerjee R., Zelent A., Price P., Acs G. RT Identification of protein-binding sites in the hepatitis RT B virus enhancer and core promoter domains RL Mol. Cell. Biol. 8:5159-5165 (1988). XX // AC T00255 XX ID T00255 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA ENKTF-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO NF-1-like XX FF possibly acting as a repressor XX BS R00421; HS$FIX_01; Quality: 6; human, Homo sapiens BS R03210; HS$PGK_03; Quality: 6; human, Homo sapiens BS R01256; HS$PK_01; Quality: 6; human, Homo sapiens XX RN [1] RA Comb M., Mermod N., Hyman S. E., Pearlberg J., Ross M. E., Goodman H. M. RT Proteins bound adjacent DNA elements act synergistically RT to regulate human proenkephalin cAMP inducible transcription RL EMBO J. 7:3793-3805 (1988). RN [2] RA Chu H.-M., Fischer W. H., Osborne T. F., Comb M. J. RT NF-I proteins from brain interact with the proenkephalin RT cAMP inducible enhancer RL Nucleic Acids Res. 19:2721 (1991). XX // AC T00258 XX ID T00258 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA ER XX SY estrogen receptor; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.1.4.1. XX SZ 600 AA; 67.0 kDa; 70 kDa (SDS) XX SQ MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPAVFNYPEGAAY SQ EFNAAAAAAAAGASAPVYGQSSITYGPGSEAAAFGANSLGAFPQLNSVSPSPLMLLHPPP SQ HVSPFLHPHGHQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSSEKGNMI SQ MESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRK SQ SCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGTSGDMRAANLWPSP SQ LVIKHTKKNSPALSLTADQMVSALLDAEPPLIYSEYDPSRPFSEASMMGLLTNLADRELV SQ HMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQG SQ KCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHI SQ HRVLDKINDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVP SQ LYDLLLEMLDAHRLHAPASRMGVPPEEPSQSQLTTTSSTSAHSLQTYYIPPEAEGFPNTI XX SC SwissProt #P06211 XX FT 1 38 region A FT 39 185 region B FT 186 268 region C, DNA-binding domain (DBD) FT 261 268 constitutive nuclear localization signal (by homology) FT 269 307 region D FT 270 278 constitutive nuclear localization signal (by homology) FT 304 308 constitutive nuclear localization signal (by homology) FT 308 558 region E, hormone-binding domain (HBD) FT 559 600 region F XX SF 1H NMR: 2 zinc ions coordinated by 4 Cys within each zinc finger SF 2 perpendicular alpha-helices XX FF mediates gene regulation in response to estrogen hormone XX IN T00258; ER; rat, Rattus norvegicus. XX BS R03564; AS$ER_03; Quality: 6 BS R03565; AS$TR_03; Quality: 6 BS R02150; ER$CONS; Quality: 6 BS R03570; HS$GFER_01; Quality: 6; human, Homo sapiens BS R03571; HS$GFER_02; Quality: 6; human, Homo sapiens BS R03572; HS$GFER_03; Quality: 6; human, Homo sapiens BS R03573; HS$GFER_04; Quality: 6; human, Homo sapiens BS R03574; HS$GFER_05; Quality: 6; human, Homo sapiens BS R02926; RAT$CABD9_01; Quality: 1; rat, Rattus norvegicus BS R03480; RAT$LHB_01; Quality: 1; rat, Rattus norvegicus BS R01586; XENLA$VITA2_01; Quality: 1; clawed frog, Xenopus laevis XX DR EMBL: Y00102; RNERR(r). DR EMBL: X61098; RNESTROR(r). DR SwissProt: P06211; ESTR_RAT. DR PIR: S07379; S07379. XX RN [1] RA Schwabe J. W. R., Neuhaus D., Rhodes D. RT Solution structure of the DNA-binding domain of the oestrogen receptor RL Nature 348:458-461 (1990). RN [2] RA Shupnik M. A., Rosenzweig B. A. RT Identification of an estrogen-responsive element in the rat LHbeta gene RL J. Biol. Chem. 266:17084-17091 (1991). RN [3] RA Koike S., Sakai M., Muramatsu M. RT Molecular cloning and characterization of rat estrogen receptor cDNA RL Nucleic Acids Res. 15:2499-2513 (1987). RN [4] RA Seyfred M. A., Gorski J. RT An interaction between the 5' flanking distal and RT proximal regulatory domains of the rat prolactin gene RT is required for transcriptinal activation by estrogens RL Mol. Endocrinol. 4:1226-1234 (1990). RN [5] RA Lubahn D. B., McCarty Jr. K. S., McCarty Sr. K. S. RT Electrophoretic characterization of purified bovine, RT porcine, murine, rat, and human uterine estrogen receptors RL J. Biol. Chem. 260:2515-2526 (1985). RN [6] RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA RT oncogene is in part due to a mutation in the DNA binding RT domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). XX // AC T00259 XX ID T00259 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA ER XX SY estrogen receptor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.1.4.1. XX SZ 599 AA; 67.0 kDa (cDNA), 65 kDa (SDS) [6], 70 kDa (SDS) [8]; XX SQ MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAY SQ EFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQ SQ LSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIM SQ ESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKS SQ CQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPL SQ VIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVH SQ MINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGK SQ CVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIH SQ RVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPL SQ YDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI XX SC SwissProt #P19785 XX FT 1 38 region A FT 39 184 region B FT 185 267 region C, DNA-binding domain (DBD) FT 268 306 region D FT 307 557 region E, hormone-binding domain (HBD) FT 558 599 region F FT 260 267 constitutive nuclear localization signal (by homology) FT 269 277 constitutive nuclear localization signal (by homology) FT 303 307 constitutive nuclear localization signal (by homology) XX SF 1H NMR, crystal structure: 2 zinc ions coordinated SF by 4 Cys within each zinc finger SF 2 perpendicular alpha-helices [1], [7]; SF C-terminal transcription activating function (TAF-2): hormone-inducible [5]; XX FF activates transcription in response to estrogen hormones [5]; FF antiestrogen ICI 164,384 inhibits DNA-binding by impairing FF receptor dimerization [3], [4]; XX IN T00259; ER; mouse, Mus musculus. IN T01454; Hsp90; mouse, Mus musculus. XX BS R00417; AS$ER_01; Quality: 2 BS R03564; AS$ER_03; Quality: 6 BS R03565; AS$TR_03; Quality: 6 BS R02150; ER$CONS; Quality: 1 BS R03563; MOUSE$LFER_01; Quality: 6; mouse, Mus musculus XX DR EMBL: M38651; MMESTRU(r). DR SwissProt: P19785; ESTR_MOUSE. DR PIR: A40061; A40061. DR Compel: C00019 XX RN [1] RA Schwabe J. W. R., Neuhaus D., Rhodes D. RT Solution structure of the DNA-binding domain of the oestrogen receptor RL Nature 348:458-461 (1990). RN [2] RA Liu Y., Teng C. T. RT Estrogen response module of the mouse lactoferrin RT gene contains overlapping chicken ovalbumin up-stream RT promoter transcription factor and estrogen receptor-binding elements RL Mol. Endocrinol. 6:355-364 (1992). RN [3] RA Fawell S. E., White R., Hoare S., Sydenham M., Page M., Parker M. G. RT Inhibition of estrogen receptor-DNA binding by the RT pure antiestrogen ICI 164,384 appears to be mediated RT by impaired receptor dimerization RL Proc. Natl. Acad. Sci. USA 87:6883-6887 (1990). RN [4] RA Arbuckle N. D., Dauvois S., Parker M. G. RT Effects of antioestrogens on the DNA binding activity RT of oestrogen receptors in vitro RL Nucleic Acids Res. 29:3839-3844 (1992). RN [5] RA Danielian P. S., White R., Lees J. A., Parker M. G. RT Identification of a conserved region required for RT hormone dependent transcriptional activation by steroid hormone receptors RL EMBO J. 11:1025-1033 (1992). RN [6] RA Golding T. S., Korach K. RT Nuclear estrogen receptor molecular heterogenity in the mouse uterus RL Proc. Natl. Acad. Sci. USA 85:69-73 (1988). RN [7] RA Schwabe J. W. R., Chapman L., Finch J. T., Rhodes D. RT The crystal structure of the estrogen receptor DNA-binding RT domain bound to DNA: how receptors discriminate between RT their response elements RL Cell 75:567-578 (1993). RN [8] RA Lubahn D. B., McCarty Jr. K. S., McCarty Sr. K. S. RT Electrophoretic characterization of purified bovine, RT porcine, murine, rat, and human uterine estrogen receptors RL J. Biol. Chem. 260:2515-2526 (1985). RN [9] RA Fawell S. E., Lees J. A., White R., Parker M. G. RT Characterization and colocalization of steroid binding RT and dimerization activities in the mouse estrogen receptor RL Cell 60:953-962 (1990). RN [10] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [11] RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA RT oncogene is in part due to a mutation in the DNA binding RT domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). XX // AC T00260 XX ID T00260 XX DT 26.01.93 (created); hse. XX FA ER XX SY estrogen receptor; XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX CL C0002; CC (rec); . XX BS R02150; ER$CONS; Quality: 6 XX RN [1] RA Green S., Walter P., Kumar V., Krust A., Bornert J.-M., Argos P., Chambon P. RT Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A RL Nature 320:134-139 (1986). RN [2] RA Fawell S. E., Lees J. A., White R., Parker M. G. RT Characterization and colocalization of steroid binding RT and dimerization activities in the mouse estrogen receptor RL Cell 60:953-962 (1990). RN [3] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [4] RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor RT involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [5] RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA RT oncogene is in part due to a mutation in the DNA binding RT domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). XX // AC T00261 XX ID T00261 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA ER XX SY estrogen receptor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); 2.1.1.4.1. XX SZ 595 AA; 66.2 kDa (cDNA), 65 kDa (SDS) [10], 70 kDa (SDS) [20]; XX SQ MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY SQ EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF SQ LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK SQ ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC SQ RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR SQ SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW SQ AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG SQ MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD SQ KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL SQ LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV XX SC SwissProt #P03372 XX FT 1 38 region A FT 39 180 region B FT 181 263 region C, DNA-binding domain (DBD) FT 256 263 constitutive K/R-rich NLS (region C) FT 264 302 region D FT 265 273 constitutive K/R-rich NLS (region D) FT 299 303 constitutive K/R-rich NLS (region D/E) FT 303 553 region E, hormone-binding domain (HBD) FT 554 595 region F FT 51 149 activating function 1 (AF-1) [21]; FT 51 93 activating subdomain of AF-1 [21]; FT 102 149 activating subdomain of AF-1 [21]; XX SF 1 estrogen-inducible NLS (nuclear localization signal) within region E [2]; SF AF-1 (activating function, previously designated TAF-1): SF constitutive, independently active [5], [21]; SF in yeast, 3 independent subdomains are active (1-62, 80-113, 118-149) [21]; SF activating subdomains of AF-1 which are active in SF animal cells (51-93, 102-149) independently synergize with AF-2 [21]; SF AF-2: hormone inducible (within HBD) SF 1H NMR: 2 zinc ions coordinated by 4 Cys within each zinc finger SF 2 perpendicular alpha-helices [1], [18]; XX FF inducible NLS also inducible by hydroxy-tamoxifen, not by ICI 164,384 [2]; FF discrimination over GRE-binding through first zinc FF finger: E-203, G-204, A-206; FF TAF-1 is constitutive, but cell-specific (active in FF CEF, poorly active in HeLa) [3]; XX IN T00261; ER; human, Homo sapiens. IN T00593; NF-kappaB1; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T00992; Hsp90; human, Homo sapiens. XX BS R02715; AS$ER_02; Quality: 2 BS R03564; AS$ER_03; Quality: 6 BS R03869; AS$ER_04; Quality: 2 BS R03565; AS$TR_03; Quality: 6 BS R01194; CHICK$OA_03; Quality: 1; chick, Gallus gallus BS R01195; CHICK$OA_04; Quality: 1; chick, Gallus gallus BS R02150; ER$CONS; Quality: 1 BS R00144; HS$APOE_03; Quality: 1; human, Homo sapiens BS R03480; RAT$LHB_01; Quality: 1; rat, Rattus norvegicus BS R01586; XENLA$VITA2_01; Quality: 1; clawed frog, Xenopus laevis BS R02665; XENLA$VITB1_05; Quality: 2; clawed frog, Xenopus laevis XX DR EMBL: M12674; HSERMCF(r). DR EMBL: X03635; HSERR(r). DR SwissProt: P03372; ESTR_HUMAN. DR PIR: A94284; QRHUE. DR PDB: 1hcp; HUMAN/CHICKEN ESTROGEN RECEPTOR. XX RN [1] RA Schwabe J. W. R., Neuhaus D., Rhodes D. RT Solution structure of the DNA-binding domain of the oestrogen receptor RL Nature 348:458-461 (1990). RN [2] RA Ylikomi T., Bocquel M. T., Berry M., Gronemeyer H., Chambon P. RT Cooperation of proto-signals for nuclear accumulation RT of estrogen and progesterone receptors RL EMBO J. 11:3681-3694 (1992). RN [3] RA Mader S., Kumar V., de Verneuil H., Chambon P. RT Three amino acids of the oestrogen receptor are essential RT to its ability to distinguish an oestrogen from a RT glucocorticoid-responsive element RL Nature 338:271-275 (1989). RN [4] RA Krust A., Green S., Argos P., Kumar V., Walter P., Bornert J.-M., Chambon P. RT The chicken oestrogen receptor sequence: homology RT with v-erbA and the human oestrogen and glucocorticoid receptors RL EMBO J. 5:891-897 (1986). RN [5] RA Tora L., White J., Brou C., Tasset D., Webster N., Scheer E., Chambon P. RT The human estrogen receptor has two independent nonacidic RT transcriptional activation functions RL Cell 59:477-487 (1989). RN [6] RA Tora L., Gaub M.-P., Mader S., Dierich A., Bellard M., Chambon P. RT Cell-specific activity of a GGTCA half-palindromic RT oestrogen-responsive element in the chicken ovalbumin gene promoter RL EMBO J. 7:3771-3778 (1988). RN [7] RA Smith J. D., Melian A., Leff T., Breslow J. L. RT Expression of the Human Apolipoprotein E Gene is Regulated RT by Multiple Positive and Negative Elements RL J. Biol. Chem. 263:8300-8308 (1988). RN [8] RA Kumar V., Chambon P. RT The Estrogen Receptor Binds Tightly to Its Responsive RT Element as a Ligand-Induced Homodimer RL Cell 55:145-156 (1988). RN [9] RA Walter P., Greene S., Greene G. L., Krust A., Bornert RA J.-M., Jeltsch J. M., Staub A., Jensen E., Serace RA G., Waterfield M., Chambon P. RT Cloning of the human estrogen receptor cDNA RL Proc. Natl. Acad. Sci. USA 82:7889-7893 (1985). RN [10] RA Green S., Walter P., Kumar V., Krust A., Bornert J.-M., Argos P., Chambon P. RT Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A RL Nature 320:134-139 (1986). RN [11] RA Greene G. L., Gilna P., Waterfield M., Baker A., Hort Y., Shine J. RT Sequence and expression of human estrogen receptor complementary DNA RL Science 231:1150-1154 (1987). RN [12] RA Ponglikitmongkol M., White J. H., Chambon P. RT Synergistic activation of transcription by the human RT estrogen receptor bound to tandem responsive elements RL EMBO J. 9:2221-2231 (1990). RN [13] RA Mader S., Chambon P., White J. H. RT Defining a minimal estrogen receptor DNA binding domain RL Nucleic Acids Res. 21:1125-1132 (1993). RN [14] RA Kumar V., Green S., Stack G., Berry M., Jin J.-R., Chambon P. RT Functional domains of the human estrogen receptor RL Cell 51:941-951 (1987). RN [15] RA Kumar V., Green S., Staub A., Chambon P. RT Localization of the oestradiol-binding and putative RT DNA-binding domains of the human oestrogen receptor RL EMBO J. 5:2231-2236 (1986). RN [16] RA Ponglikitmongkol M., Green S., Chambon P. RT Genomic organization of the human oestrogen receptor gene RL EMBO J. 7:3385-3388 (1988). RN [17] RA Chambraud B., Berry M., Redeuilh G., Chambon P., Baulieu E.-E. RT Several regions of the human estrogen receptor are RT involved in the formation of receptor heat-shock protein 90 complexes RL J. Biol. Chem. 265:20686-20691 (1990). RN [18] RA Schwabe J. W. R., Chapman L., Finch J. T., Rhodes D. RT The crystal structure of the estrogen receptor DNA-binding RT domain bound to DNA: how receptors discriminate between RT their response elements RL Cell 75:567-578 (1993). RN [19] RA Gilbert D. M., Losson R., Chambon P. RT Ligand dependence of estrogen receptor induces changes RT in chromatin structure RL Nucleic Acids Res. 20:2525-2531 (1992). RN [20] RA Lubahn D. B., McCarty Jr. K. S., McCarty Sr. K. S. RT Electrophoretic characterization of purified bovine, RT porcine, murine, rat, and human uterine estrogen receptors RL J. Biol. Chem. 260:2515-2526 (1985). RN [21] RA Metzger D., Ali A., Bornet S.-M., Chambon P. RT Characterization of the amino-terminal transcriptional RT activation function of the human estrogen receptor in animal and yeast cells RL J. Biol. Chem. 270:9535-9542 (1995). RN [22] RA Martinez E., Wahli W. RT Cooperative binding of estrogen receptor to imperfect RT estrogen-responsive DNA elements correlates with their RT synergistic hormone-dependent enhancer activity RL EMBO J. 8:3781-3791 (1989). RN [23] RA Savouret J. F., Bailly A., Mirashi M., Rauch C., Redeuilh RA G., Chauchereau A., Milgrom E. RT Characterization of the hormone responsive element RT involved in the regulation of the progesterone receptor gene RL EMBO J. 10:1875-1883 (1991). RN [24] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [25] RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA RT oncogene is in part due to a mutation in the DNA binding RT domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). XX // AC T00262 XX ID T00262 XX DT 15.10.92 (created); ewi. DT 08.02.96 (updated); ewi. XX FA ER XX SY estrogen receptor; XX OS cattle, Bos taurus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; artiodactyla; ruminantia; pecora; bovidae XX CL C0002; CC (rec); . XX SZ 65 kDa (SDS) [2], 66 kDa (SDS) [1], 70 kDa (SDS) [6], [5]; XX SF metal binding, reconstitution of DNA-binding after SF EDTA-treatment with zinc or cadmium ions SF 8-9 S (transformation) -> 5 S (DNA-binding) (NaSCN) -> 3.7 S [2]; XX CP (uterus) XX IN T00262; ER; cattle, Bos taurus. XX BS R02150; ER$CONS; Quality: 6 BS R03269; RABBIT$PR_01; Quality: 1; rabbit, Oryctolagus cuniculus BS R03272; RABBIT$PR_04; Quality: 1; rabbit, Oryctolagus cuniculus BS R03273; RABBIT$PR_05; Quality: 1; rabbit, Oryctolagus cuniculus BS R01262; RAT$PL_01; Quality: 2; rat, Rattus norvegicus BS R01267; RAT$PL_06; Quality: 1; rat, Rattus norvegicus XX DR EMBL: X66841; BTEREC(r). XX RN [1] RA Sabbah M., Redeuilh G., Secco C., Baulieu E.-E. RT The binding activity of estrogen receptor to DNA and RT heat shock protein (Mr 90,000) is dependent on receptor-bound metal RL J. Biol. Chem. 262:8631-8635 (1987). RN [2] RA Sabbah M., Redeuilh G., Baulieu E.-E. RT Subunit composition of the estrogen receptor RL J. Biol. Chem. 264:2397-2400 (1989). RN [3] RA Maurer R. A., Notides A. C. RT Identification of an Estrogen-Responsive Element from RT the 5'-Flanking Region of the Rat Prolactin Gene RL Mol. Cell. Biol. 7:4247-4254 (1987). RN [4] RA Lannigan D. A., Notides A. C. RT Estrogen receptor selectively binds the coding strand RT of an estrogen responsive element RL Proc. Natl. Acad. Sci. USA 86:863-867 (1989). RN [5] RA Lubahn D. B., McCarty Jr. K. S., McCarty Sr. K. S. RT Electrophoretic characterization of purified bovine, RT porcine, murine, rat, and human uterine estrogen receptors RL J. Biol. Chem. 260:2515-2526 (1985). RN [6] RA Redeuilh G., Richard-Foy R., Secco C., Torelli V., RA Bucourt R., Baulieu E. -E., Richard-Foy H. RT Properties of Biospecific Absorbents, obtained by RT immobilization of oestradiol 7a-derivatives, for purification RT of calf-uterine cytosol oestradiol receptor RL Eur. J. Biochem. 106:481-493 (1980). RN [7] RA Sica V., Brescani F. RT Estrogen-binding proteins of calf uterus. Purification RT to homogeneity of receptor from cytosol by affinity chromatography. RL Biochemistry 18:2369-2378 (1979). XX // AC T00263 XX ID T00263 XX DT 17.11.92 (created); ewi. DT 08.02.96 (updated); ewi. XX FA ER XX SY estrogen receptor; XX OS clawed frog, Xenopus laevis OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CL C0002; CC (rec); 2.1.1.4.1. XX SZ 61 kDa (SDS), 66 kDa (SDS) [4]; XX SF N-terminally truncated forms are known [4]; XX IN T00263; ER; clawed frog, Xenopus laevis. XX BS R02150; ER$CONS; Quality: 6 BS R01586; XENLA$VITA2_01; Quality: 1; clawed frog, Xenopus laevis BS R01591; XENLA$VITB2_01; Quality: 2; clawed frog, Xenopus BS R01592; XENLA$VITB2_02; Quality: 2; clawed frog, Xenopus XX DR EMBL: L20735; XLESTRREC(r). XX RN [1] RA Corthesy B., Cardinaux J.-R., Claret F.-X., Wahli W. RT A nuclear factor I-like activity and a liver-specific RT repressor govern estrogen-regulated in vitro transcription RT from the Xenopus laevis vitellogenin B1 promoter RL Mol. Cell. Biol. 9:5548-5562 (1989). RN [2] RA Weiler I. J., Lew D. RT The Xenopus laevis estrogen receptor: Sequence homology RT with human and avian receptors and identification RT of multiple estrogen receptor messenger ribonucleic acids RL Mol. Endocrinol. 1:355-362 (1987). RN [3] RA ten Heggeler-Bordier B., Hipskind R., Seiler-Tuyns RA A., Martinez E., Corthėsy B. RT Electron microscopic visualization of protein-DNA RT interactions at the estrogen responsive element and RT in the first intron of the Xenopus laevis vitellogenin gene RL EMBO J. 6:1715-1720 (1987). RN [4] RA Claret F.-X., Chapel S., Garces J., Tsai-Pflugfelder RA M., Bertholet C., Shapiro D. J., Wittek R., Wahli W. RT Two functional forms of the Xenopus laevis estrogen RT receptor translated from a single mRNA species RL J. Biol. Chem. 269:14047-14055 (1994). RN [5] RA Corthesy B., Claret F.-X., Wahli W. RT Estrogen receptor level determines sex-specific in RT vitro transcription from the Xenopus vitellogenin promoter RL Proc. Natl. Acad. Sci. USA 87:7878-7882 (1990). XX // AC T00264 XX ID T00264 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA ER XX SY estrogen receptor; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0002; CC (rec); 2.1.1.4.1. XX SZ 589 AA; 66.7 kDa (cDNA) XX SQ MTMTLHTKASGVTLLHQIQGTELETLSRPQLKIPLERSLSDMYVESNKTGVFNYPEGATY SQ DFGTTAPVYGSTTLSYAPTSESFGSSSLAGFHSLNNVPPSPVVFLQTAPQLSPFIHHHSQ SQ QVPYYLENEQGSFGMREAAPPAFYRPSSDNRRHSIRERMSSTNEKGSLSMESTKETRYCA SQ VCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCY SQ EVGMMKGGIRKDRRGGEMMKQKRQREEQDSRNGEASSTELRAPTLWTSPLVVKHNKKNSP SQ ALSLTAEQMVSALLEAEPPIVYSEYDPNRPFNEASMMTLLTNLADRELVHMINWAKRVPG SQ FVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFD SQ MLLATAARFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEERDYIHRVLDKITDTL SQ IHLMAKSGLSLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDA SQ HRLHAPAARSAAPMEEENRNQLTTAPASSHSLQSFYINSKEEESMQNTI XX SC SwissProt #P06212 XX FT 1 174 region A/B FT 175 258 region C, DNA-binding domain (DBD) FT 259 296 region D FT 297 589 region E/F, hormone-binding domain (HBD) FT 250 257 constitutive nuclear localization signal (by homology) FT 260 268 constitutive nuclear localization signal (by homology) FT 293 297 constitutive nuclear localization signal (by homology) XX SF 1H NMR: 2 zinc ions coordinated by 4 Cys within each zinc finger SF 2 perpendicular alpha-helices [1], [8]; XX FF cooperative binding to several widely spaced half-sites [2]; FF cooperative effects with AP-1 do not require DNA-binding by ER [10]; XX IN T00264; ER; chick, Gallus gallus. XX BS R03564; AS$ER_03; Quality: 6 BS R03565; AS$TR_03; Quality: 6 BS R00153; CHICK$APOVLDL_01; Quality: 4; chick, Gallus gallus BS R00154; CHICK$APOVLDL_02; Quality: 4; chick, Gallus gallus BS R03566; CHICK$OA_12; Quality: 6; chick, Gallus gallus BS R03567; CHICK$OA_13; Quality: 6; chick, Gallus gallus BS R03568; CHICK$OA_14; Quality: 6; chick, Gallus gallus BS R03569; CHICK$OA_15; Quality: 6; chick, Gallus gallus BS R01568; CHICK$VIT2_01; Quality: 4; chick, Gallus gallus BS R01570; CHICK$VIT2_03; Quality: 4; chick, Gallus gallus BS R01571; CHICK$VIT2_04; Quality: 4; chick, Gallus gallus BS R01573; CHICK$VIT2_06; Quality: 2; chick, Gallus gallus BS R01577; CHICK$VIT2_10; Quality: 4; chick, Gallus gallus BS R01579; CHICK$VIT2_12; Quality: 4; chick, Gallus gallus BS R02150; ER$CONS; Quality: 6 XX DR EMBL: X03805; GGERR(r). DR SwissProt: P06212; ESTR_CHICK. DR PIR: S07192; S07192. DR PDB: 1hcp; HUMAN/CHICKEN ESTROGEN RECEPTOR. XX RN [1] RA Schwabe J. W. R., Neuhaus D., Rhodes D. RT Solution structure of the DNA-binding domain of the oestrogen receptor RL Nature 348:458-461 (1990). RN [2] RA Kato S., Tora L., Yamauchi J., Masushige S., Bellard M., Chambon P. RT A far upstream estrogen response element of the ovalbumin RT gene contains several half-palindromic 5'-TGACC-3' RT motifs acting synergistically RL Cell 68:731-742 (1992). RN [3] RA Wijnholds J., Philipsen J. N. J., Ab G. RT Tissue-specific and steroid-dependent interaction RT of transcription factors with the oestrogen-inducible RT apoVLDL II promoter in vivo RL EMBO J. 7:2757-2763 (1988). RN [4] RA Philipsen J. N. J., Hennis B. C., Ab G. RT In vivo footprinting of the estrogen-inducible vitellogenin RT II gene from chicken RL Nucleic Acids Res. 16:9663-9676 (1988). RN [5] RA Jost J.-P., Seldram M., Geiser M. RT Preferential binding of estrogen-receptor complex RT to a region containing the estrogen-dependent hypomethylation RT site preceding the chicken vitellogenin II gene RL Proc. Natl. Acad. Sci. USA 81:429-433 (1984). RN [6] RA Saluz H. P., Jiricny J., Jost J. P. RT Genomic sequencing reveals a positive correlation RT between the kinetics of strand-specific DNA demethylation RT of the overlapping estradiol/glucocorticoid-receptor RT binding sites and the rate of avian vitellogenin mRNA synthesis RL Proc. Natl. Acad. Sci. USA 83:7167-7171 (1986). RN [7] RA Krust A., Green S., Argos P., Kumar V., Walter P., Bornert J.-M., Chambon P. RT The chicken oestrogen receptor sequence: homology RT with v-erbA and the human oestrogen and glucocorticoid receptors RL EMBO J. 5:891-897 (1986). RN [8] RA Schwabe J. W. R., Chapman L., Finch J. T., Rhodes D. RT The crystal structure of the estrogen receptor DNA-binding RT domain bound to DNA: how receptors discriminate between RT their response elements RL Cell 75:567-578 (1993). RN [9] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [10] RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor RT involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [11] RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA RT oncogene is in part due to a mutation in the DNA binding RT domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). XX // AC T00265 XX ID T00265 XX DT 27.10.92 (created); ewi. DT 22.05.97 (updated); ewi. XX FA Erg-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0016; ETS; 3.5.2.0.8.1. XX SZ 363 AA; 41.4 kDa (cDNA) XX SQ MVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGL SQ PDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKAL SQ QNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQIL SQ GPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKS SQ KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLP SQ YMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLG SQ TYY XX SC SwissProt #P11308 and edited XX FT 38 105 POINTED domain of homology [2]; FT 191 275 ETS domain FT 198 235 tryptophan cluster (W-X17-W-X18-W) XX SF additional splice variants: Erg-2 , p38erg, p55erg, p49erg [5], [1]; XX FF activator [1]; FF overexpression in murine erythroleukemia cells may FF cause enhanced growth factor independence [4]; XX DR EMBL: M17254; HSERG2(r). DR SwissProt: P11308; ERG_HUMAN. DR PIR: A29515; TVHUEG. XX RN [1] RA Duterque-Coquillaud M., Niel C., Plaza S., Stehelin D. RT New human erg isoforms generated by alternative splicing RT are transcriptional activators RL Oncogene 8:1865-1873 (1993). RN [2] RA Klaembt C. RT The Drosophila gene pointed encodes two ETS-like proteins RT which are involved in the development of the midline glial cells RL Development 117:163-176 (1993). RN [3] RA Shimizu K., Ichikawa H., Tojo A., Kaneko Y., Maseki RA N., Hayashi Y., Ohira M., Asano S., Ohki M. RT An ets-related gene, ERG, is rearranged in human myeloid RT leukemia with t(16;21) chromosomal translocation RL Proc. Natl. Acad. Sci. USA 90:10280-10284 (1993). RN [4] RA Nibbs R. J. B., Itoh K., Ostertag W., Harrison P. R. RT Differentiation arrest and stronal cell-independent RT growth of murine erythroleukemia cells are associated RT with elevated expression of ets-related genes but not with mutation of p53 RL Mol. Cell. Biol. 13:5582-5592 (1993). RN [5] RA Rao V. N., Papas T. S., Reddy E. S. RT erg, a human ets-related gene on chromosome 21: alternative RT splicing, polyadenylation, and translation RL Science 237:635-639 (1987). RN [6] RA Karim F. D., Urness L. D., Thummel C. S., Klemsz M. RA J., McKercher S. R., Celada A., van Beveren C., Maki RA R. A., Gunther C. V., Nye J. A., Graves B. J. RT The ETS-domain: a new DNA-binding motif that recognizes RT a purine-rich core DNA sequence RL Genes Dev. 4:1451-1453 (1990). RN [7] RA Reddy E. S. P., Rao V. N. RT erg, an ets-related gene, codes for sequence-specific RT transcriptional activators RL Oncogene 6:2285-2289 (1991). XX // AC T00266 XX ID T00266 XX DT 27.10.92 (created); ewi. DT 22.05.97 (updated); ewi. XX FA Erg-2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0016; ETS; 3.5.2.0.8.2. XX SZ 462 AA; 52.0 kDa (cDNA) XX SQ MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ SQ QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM SQ PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK SQ DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRR SQ SAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFL SQ LELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNI SQ MTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPA SQ LPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY XX SC SwissProt #P11308 XX FT 137 204 POINTED domain of homology [2]; FT 290 374 ETS domain FT 297 334 tryptophan cluster (W-X17-W-X18-W) XX SF an additional exon in front of the Erg-1 ATG leads SF to alternative translation initiation SF splice variants: Erg-1, p38erg, p55erg, p49erg [1]; XX FF activator [1]; FF overexpression in murine erythroleukemia cells may FF cause enhanced growth factor independence [4]; XX DR EMBL: M17254; HSERG2(r). DR SwissProt: P11308; ERG_HUMAN. DR PIR: A29515; TVHUEG. XX RN [1] RA Duterque-Coquillaud M., Niel C., Plaza S., Stehelin D. RT New human erg isoforms generated by alternative splicing RT are transcriptional activators RL Oncogene 8:1865-1873 (1993). RN [2] RA Klaembt C. RT The Drosophila gene pointed encodes two ETS-like proteins RT which are involved in the development of the midline glial cells RL Development 117:163-176 (1993). RN [3] RA Shimizu K., Ichikawa H., Tojo A., Kaneko Y., Maseki RA N., Hayashi Y., Ohira M., Asano S., Ohki M. RT An ets-related gene, ERG, is rearranged in human myeloid RT leukemia with t(16;21) chromosomal translocation RL Proc. Natl. Acad. Sci. USA 90:10280-10284 (1993). RN [4] RA Nibbs R. J. B., Itoh K., Ostertag W., Harrison P. R. RT Differentiation arrest and stronal cell-independent RT growth of murine erythroleukemia cells are associated RT with elevated expression of ets-related genes but not with mutation of p53 RL Mol. Cell. Biol. 13:5582-5592 (1993). RN [5] RA Rao V. N., Papas T. S., Reddy E. S. RT erg, a human ets-related gene on chromosome 21: alternative RT splicing, polyadenylation, and translation RL Science 237:635-639 (1987). RN [6] RA Karim F. D., Urness L. D., Thummel C. S., Klemsz M. RA J., McKercher S. R., Celada A., van Beveren C., Maki RA R. A., Gunther C. V., Nye J. A., Graves B. J. RT The ETS-domain: a new DNA-binding motif that recognizes RT a purine-rich core DNA sequence RL Genes Dev. 4:1451-1453 (1990). RN [7] RA Reddy E. S. P., Rao V. N. RT erg, an ets-related gene, codes for sequence-specific RT transcriptional activators RL Oncogene 6:2285-2289 (1991). XX // AC T00267 XX ID T00267 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GATA-1 XX SY EF1; EFgammaa; Eryf-1; Eryf1; GF-1; NF-E1; NF-E1a; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0003; CC (g); 2.2.1.1.1.1. XX SZ 304 AA; 31.4 kDa (cDNA), 38, 72 kDa (SDS) XX SQ MEFVALGGPDAGSPTPFPDEAGAFLGLGGGERTEAGGLLASYPPSGRVSLVPWADTGTLG SQ TPQWVPPATQMEPPHYLELLQPPRGSPPHPSSGPLLPLSSGPPPCEARECVNCGATATPL SQ WRRDGTGHYLCNACGLYHRLNGQNRPLIRPKKRLLVSKRAGTVCSNCQTSTTTLWRRSPM SQ GDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKVSSKGKKRRPPGGGNPSATAGGGAPM SQ GGGGDPSMPPPPPPPAAAPPQSDALYALGPVVLSGHFLPFGNSGGFFGGGAGGYTAPPGL SQ SPQI XX SC SwissProt #P17678 XX FT 1 71 transcription activation domain Act1 FT 84 121 Act2 FT 110 134 first zinc finger FT 164 188 second zinc finger FT 234 304 Act3 XX SF only the second zinc finger is critical for DNA-binding [1]; SF 72 kDa: co-purifying minor component with same binding specificity XX CP erythroid cells XX MX M00126; V$GATA1_02 MX M00127; V$GATA1_03 MX M00128; V$GATA1_04 MX M00203; V$GATA_C XX BS R02892; AS$GATA1_01; Quality: 2; chick, Gallus gallus BS R00513; CHICK$AAG_07; Quality: 1; chick, Gallus gallus BS R00514; CHICK$AAG_08; Quality: 1; chick, Gallus gallus BS R00515; CHICK$AAG_09; Quality: 1; chick, Gallus gallus BS R00518; CHICK$ADG_03; Quality: 1; chick, Gallus gallus BS R01949; CHICK$BG_07; Quality: 1; chick, Gallus gallus BS R00536; CHICK$BHG_02; Quality: 2; chick, Gallus gallus BS R00538; CHICK$BHG_04; Quality: 2; chick, Gallus gallus BS R00539; CHICK$BHG_05; Quality: 2; chick, Gallus gallus BS R03087; CHICK$GATA1_01; Quality: 2; chick, Gallus gallus BS R03093; CHICK$GATA1_07; Quality: 2; chick, Gallus gallus BS R02156; GATA1$CONS; Quality: 1 BS R00507; MOUSE$AAG_01; Quality: 2; mouse, Mus musculus XX DR EMBL: M26209; GGRERYF1(r). DR SwissProt: P17678; GAT1_CHICK. DR PIR: A32993; A32993. DR PDB: 1gat; ERYTHROID TRANSCRIPTION FACTOR GATA-1(NMR, MINIMIZED AVERAGE STRUCTURE) CHICKEN. DR PDB: 1gau; ERYTHROID TRANSCRIPTION FACTOR GATA-1(NMR, 30 STRUCTURES) CHICKEN. XX RN [1] RA Yang H.-Y., Evans T. RT Distinct roles for the two cGATA-1 finger domains RL Mol. Cell. Biol. 12:4562-4570 (1992). RN [2] RA Barnhart K. M., Kim C. G., Sheffery M. RT Purification and characterization of an erythroid RT cell-specific factor that binds the murine alpha- and beta-globin genes RL Mol. Cell. Biol. 9:2606-2614 (1989). RN [3] RA Knezetic J. A., Felsenfeld G. RT Identification and Characterization of a Chicken alpha-Globin Enhancer RL Mol. Cell. Biol. 9:893-901 (1989). RN [4] RA Perkins N. D., Nicolas R. H., Plumb M. A., Goodwin G. H. RT The purification of an erythroid protein which binds RT to enhancer and promoter elements of haemoglobin genes RL Nucleic Acids Res. 17:1299-1314 (1989). RN [5] RA Evans T., Reitman M., Felsenfeld G. RT An erythrocyte-specific DNA-binding factor recognizes RT a regulatory sequence common to all chicken globin genes RL Proc. Natl. Acad. Sci. USA 85:5976-5980 (1988). RN [6] RA Evans T., Felsenfeld G. RT The erythroid-specific transcription factor Eryf1: A new finger protein RL Cell 58:877-885 (1989). RN [7] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S., Engel J. D. RT Acitivity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). RN [8] RA Evans T., Felsenfeld G. RT trans-activation of a globin promoter in nonerythroid cells RL Mol. Cell. Biol. 11:843-853 (1991). RN [9] RA Orkin S. H. RT Globin gene regulation and switching: Circa 1990 RL Cell 63:665-672 (1990). RN [10] RA Pevny L., Simon M. C., Robertson E., Klein W. H., RA Tsai S.-F., D'Agati V., Orkin S. H., Constantini F. RT Erythroid differentiation in chimaeric mice blocked RT by a targeted mutation in the gene for transcription factor GATA-1 RL Nature 349:257-260 (1991). RN [11] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D. RT Activity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). RN [12] RA Evans T., Felsenfeld G. RT trans-activation of a globin promoter in nonerythroid cells RL Mol. Cell. Biol. 11:843-853 (1991). RN [13] RA Hannon R., Evans T., Felsenfeld G., Gould H. RT Structure and promoter activity of the gene for the RT erythroid transcription factor GATA-1 RL Proc. Natl. Acad. Sci. USA 86:3004-3008 (1991). XX // AC T00268 XX ID T00268 XX DT 15.10.92 (created); ewi. DT 09.06.97 (updated); ewi. XX FA GABP XX SY E4TF1; GA binding protein; NRF-2; nuclear respiratory factor 2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0016; ETS; . XX SZ 56 kDa (alpha), 48 kDa (beta1), 46 kDa (beta2), 41 kDa (gamma1), SZ 39 kDa (gamma2) (SDS) XX SF tetrameric molecule of a GABP-beta1 (E4TF1-53) homodimer SF and two GABP-alpha (E4TF1-60) monomers, or a heterodimer SF of GABP-beta2 (E4TF1-47) and GABP-alpha (E4TF1-60) [6], [3], [2]; XX CP broad distribution XX FF activator; FF may be related to or identical with EF-1A XX BS R00357; AD$E4_11; Quality: 6; adenovirus type 5 BS R02143; E4TF1$CONS; Quality: 2 BS R03472; RAT$COX4_01; Quality: 6; rat, Rattus norvegicus BS R03473; RAT$COX4_02; Quality: 6; rat, Rattus norvegicus XX DR EMBL: D13316; HSTF147(r). DR EMBL: D13317; HSTF153(r). DR EMBL: D13318; HSTF160(r). XX RN [1] RA Virbasius J. V., Scarpulla R. C. RT Transcriptional activation through ETS domain binding RT sites in the cytochrome c oxidase subunit IV gene RL Mol. Cell. Biol. 11:5631-5638 (1991). RN [2] RA Sawada J.-I., Goto M., Sawa C., Watanabe H., Handa H. RT Transcriptional activation through the tetrameric RT complex formation of E4TF1 subunits RL EMBO J. 13:1396-1402 (1994). RN [3] RA Watanabe H., Sawada J.-I., Yano K.-I., Yamaguchi K., Goto M., Handa H. RT cDNA cloning of transcription factor E4TF1 subunits RT with Ets and Notch motifs RL Mol. Cell. Biol. 13:1385-1391 (1993). RN [4] RA Virbasius J. V., Virbasius C.-M. A., Scarpulla R. C. RT Identity of GABP with NRF-2, a multisubunit activator RT of cytochrome oxidase expression, reveals a cellular RT role for an Ets domain activator of viral promoters RL Genes Dev. 7:380-392 (1993). RN [5] RA Watanabe H., Imai T., Sharp P. A., Handa H. RT Identification of two transcription factors that bind RT to specific elements in the promoter of the adenovirus early-region 4 RL Mol. Cell. Biol. 8:1290-1300 (1988). RN [6] RA Watanabe H., Wada T., Handa H. RT Transcription factor E4TF1 contains two subunits with different functions RL EMBO J. 9:841-847 (1990). RN [7] RA Hanaka S., Nishigaki T., Sharp P. A., Handa H. RT Regulation of in vitro and in vivo transcription of RT early-region IV of adenovirus type 5 by multiple cis-acting elements RL Mol. Cell. Biol. 7:2578-2587 (1987). XX // AC T00269 XX ID T00269 XX DT 15.10.92 (created); ewi. XX FA E4TF2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R00358; AD$E4_12; Quality: 6; adenovirus type 5 XX RN [1] RA Watanabe H., Imai T., Sharp P. A., Handa H. RT Identification of two transcription factors that bind RT to specific elements in the promoter of the adenovirus early-region 4 RL Mol. Cell. Biol. 8:1290-1300 (1988). XX // AC T00270 XX ID T00270 XX DT 15.10.92 (created); ewi. XX FA ETF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 120 kDa XX BS R00042; CHICK$BAC_01; Quality: 2; chick, Gallus gallus BS R00043; CHICK$BAC_02; Quality: 2; chick, Gallus gallus BS R00044; CHICK$BAC_03; Quality: 2; chick, Gallus gallus BS R00045; CHICK$BAC_04; Quality: 2; chick, Gallus gallus BS R00046; CHICK$BAC_05; Quality: 2; chick, Gallus gallus BS R02640; CHICK$BAC_07; Quality: 2; chick, Gallus gallus BS R02152; ETF$CONS; Quality: 2 BS R00379; HS$EGFR_06; Quality: 6; human, Homo sapiens BS R00380; HS$EGFR_07; Quality: 6; human, Homo sapiens BS R00382; HS$EGFR_09; Quality: 6; human, Homo sapiens BS R01371; SV$SV40_03; Quality: 6; SV40, simian virus 40 BS R01375; SV$SV40_07; Quality: 6; SV40, simian virus 40 XX RN [1] RA Kageyama I., Merlino R., Pastan, G.T. RT A transcription factor active on the epidermal growth factor receptor gene RL Proc. Natl. Acad. Sci. USA 85:5016-5020 (1988). RN [2] RA Kageyama R., Pastan I. RT Molecular Cloning and Characterization of a Human RT DNA Binding Factor That Represses Transcription RL Cell 59:815-825 (1989). XX // AC T00271 XX ID T00271 XX DT 30.11.92 (created); ewi. DT 17.12.96 (updated); ewi. XX FA Eve XX SY Even-skipped; XX OS grasshopper, Schistocerca americana OC eukaryota; animalia; metazoa; arthropoda; uniramia; OC insecta; pterygota; neoptera; orthopterodea XX HO Evx-1, Evx-2 (mammalia) XX CL C0006; homeo; 3.1.1.8.1. XX SZ >265 AA XX SQ VMEHQLVVSSSEDIKPPPAAHLGKPTVVVDVIPPTYTSPPVAKTESIKETPAMSTGSTAT SQ SSGNDQSIRRYRTAFTREQLARLEKEFYKENYVSRPRRCELASQLNLPESTIKVWFQNRR SQ MKDKRQRMAMAWPYAVYTDPTLAASLLQAAMYVPCPPYYPQPRYAYPYPSPSPSPSPAQP SQ QRQDDCDGSPSCRCGIVNCVAASSLPTASPSPSPLLSPPLFATGAAVAGAAAGAGSTQLA SQ RQPPKLFQPYKSDVTPHADRDRDRT XX SC translated from EMBL #Z11845 XX FT 68 127 homeo domain FT 222 234 alanine-rich region (8/13) XX FF Eve is required for normal development of certain neurons of the CNS [2]; XX DR EMBL: Z11845; SAEVESKIP(r). XX RN [1] RA Patel N. H., Condron B. G., Zinn K. RT Pair-rule expression patterns of even-skipped are RT found in both short- and long-germ beetles RL Nature 367:429-434 (1994). RN [2] RA Patel N. H., Ball E. E., Goodman C. S. RT Changing role of even-skipped during the evolution RT of insect pattern formation RL Nature 357:339-342 (1992). XX // AC T00272 XX ID T00272 XX DT 15.10.92 (created); ewi. DT 17.12.96 (updated); ewi. XX FA Eve XX SY Even-skipped; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX HO Evx-1, Evx-2 (vertebrates) XX CL C0006; homeo; 3.1.1.8.1. XX SZ 376 AA; 40.0 kDa (cDNA), 44 kDa (SDS) XX SQ MHGYRTYNMESHHAHHDASPVDQKPLVVDLLATQYGKPQTPPPSPNECLSSPDNSLNGSR SQ GSEIPADPSVRRYRTAFTRDQLGRLEKEFYKENYVSRPRRCELAAQLNLPESTIKVWFQN SQ RRMKDKRQRIAVAWPYAAVYSDPAFAASILQAAANSVGMPYPPYAPAAAAAAAAAAAVAT SQ NPMMATGMPPMGMPQMPTMQMPGHSGHAGHPSPYGQYRYTPYHIPARPAPPHPAGPHMHH SQ PHMMGSSATGSSYSAGAAGLLGALPSATCYTGLGVGVPKTQTPPLDLQSSSSPHSSTLSV SQ SPVGSDHAKVFDRSPVAQSAPSVPAPAPLTTTSPLPAPGLLMPSAKRPASDMSPPPTTTV SQ IAEPKPKLFKPYKTEA XX SC SwissProt #P06602 XX FT 70 129 homeo domain FT 165 179 alanine-rich region (13/15) XX SF equal affinity for two classes of DNA-sequences following SF two distinct consensi (A/T-rich or G/C-rich, resp.) [13], [12]; SF both types of DNA-binding are mediated by the homeo domain [13]; SF proline-rich and hydrophobic repressor domain of 57 AA [2]; SF non-repressing variants exhibit higher DNA-binding affinity [2]; XX CP odd parasegments XX FF pair-rule gene product, generally acting as repressor [14], [8], [2]; FF activator of en [13]; FF repression may occur first through affinity binding FF (KD < 1 nM), followed by subsequent medium- and low-affinity FF binding (KD = 10 nM) where competition with activator FF binding may cause the repression [3]; FF as a result, Eve may uniformly cover large sequence stretches [10]; FF before repressing, e. g., run and ftz genes, Eve transiently FF activates them during a brief 20-30 min stage in the FF development [8], as it positively autoregulates its own expression [13]; FF may also interfere with preinitiation transcription complex formation [11]; FF in addition to regulating segmentation, Eve also is FF required for normal developmet of certain neurons of the CNS [7]; FF expression is controlled by a two-step programme: FF the initial induction of a seven-stripe expression FF pattern is mediated by some gap gene (Hb, Gt, Kr; FF also: Bcd) products, different stripes being under FF control of distinct control regions of the eve gene [1], [16], [17], [9]; FF later, eve expression is regulated through a single FF region by the action of periodically expressed regulators FF such as Eve itself [6]; XX BS R00411; DROME$EN_01; Quality: 2; fruit fly, Drosophila melanogaster BS R00412; DROME$EN_02; Quality: 2; fruit fly, Drosophila melanogaster BS R00413; DROME$EN_03; Quality: 2; fruit fly, Drosophila melanogaster BS R00418; DROME$EVE_01; Quality: 6; fruit fly, Drosophila melanogaster BS R00419; DROME$EVE_02; Quality: 6; fruit fly, Drosophila melanogaster BS R03029; DROME$EVE_34; Quality: 6; fruit fly, Drosophila melanogaster BS R03031; DROME$EVE_36; Quality: 6; fruit fly, Drosophila melanogaster BS R01281; DROME$PCNA_01; Quality: 6; fruit fly, Drosophila melanogaster BS R01283; DROME$PCNA_03; Quality: 6; fruit fly, Drosophila melanogaster BS R01284; DROME$PCNA_04; Quality: 6; fruit fly, Drosophila melanogaster BS R01529; DROME$UBX_14; Quality: 6; fruit fly, Drosophila melanogaster BS R01888; DROME$UBX_16; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: M14767; DMEVE(g). DR EMBL: X05138; DMEVER(r). DR SwissProt: P06602; HMEV_DROME. DR PIR: A26066; A26066. DR Flybase: FBgn0000606; eve. XX RN [1] RA Yamaguchi M., Nishida Y., Moriuchi T., Hirose F., RA Hui C.-C., Suzuki Y., Matsugake A. RT Drosophila proliferating cell nuclear antigen (cyclin) RT gene: structure, expression during development, and RT specific binding of homeodomain proteins to its 5'-flanking region RL Mol. Cell. Biol. 10:872-879 (1990). RN [2] RA Han K., Manley J. L. RT Transcriptional repression by the Drosophila Even-skipped RT protein: definition of a minimal repression domain RL Genes Dev. 7:491-503 (1993). RN [3] RA TenHarmsel A., Austin R. J., Savenelli N., Biggin M. D. RT Cooperative binding at a distance by even-skipped RT protein correlates with repression and suggests a mechanism of silencing RL Mol. Cell. Biol. 13:2742-2752 (1993). RN [4] RA Macdonald P. M., Ingham P., Struhl G. RT Isolation, structure, and expression of even-skipped: RT A second pair-rule gene of Drosophila containing a homeo box RL Cell 47:721-734 (1986). RN [5] RA Frasch M., Hoey T., Rushlow C., Doyle H., Levine M. RT Characterization and localization of the even-skipped protein of Drosophila RL EMBO J. 6:749-759 (1987). RN [6] RA Goto T., Macdonald P., Maniatis T. RT Early and late periodic patterns of even skipped expression RT are controlled by distinct regulatory elements that RT respond to different spatial cues RL Cell 57:413-422 (1989). RN [7] RA Doe C. Q., Smouse D., Goodman C. S. RT Control of neuronal fate by the Drosophila segmentation gene even-skipped RL Nature 333:376-378 (1988). RN [8] RA Manoukian A. S., Krause H. M. RT Concentration-dependent activities of the even-skipped RT protein in Drosophila embryos RL Genes Dev. 6:1740-1751 (1992). RN [9] RA Small S., Blair A., Levine M. RT Regulation of even-skipped stripe 2 in the Drosophila embryo RL EMBO J. 11:4047-4057 (1992). RN [10] RA Walter J., Dever C. A., Biggin M. D. RT Two homeo domain proteins bind with similar specificity RT to a wide range of DNA sites in Drosophila embryos RL Genes Dev. 8:1678-1692 (1994). RN [11] RA Johnson F. B., Krasnow M. A. RT Differential regulation of transcription preinitiation RT complex assembly by activator and repressor homeo domain protein RL Genes Dev. 6:2177-2189 (1992). RN [12] RA Hoey T., Levine M. RT Divergent homeo box proteins recognize similar DNA sequences in Drosophila RL Nature 332:858-861 (1988). RN [13] RA Hoey T., Warrior R., Manak J., Levine M. RT DNA-Binding Activities of Drosophila melanogaster RT even-skipped Protein Are Mediated by Its Homeo Domain RT and Influenced by Protein Context RL Mol. Cell. Biol. 8:4598-4607 (1988). RN [14] RA Biggin M. D., Tjian R. RT A Purified Drosophila Homeodomain Protein Represses Transcription In Vitro RL Cell 58:433-440 (1989). RN [15] RA Jiang J., Hoey T., Levine M. RT Autoregulation of a segmentation gene in Drosophila: RT combinatorial interaction of the even-skipped homeo RT box protein with a distal enhancer element RL Genes Dev. 5:265-277 (1991). RN [16] RA Small S., Kraut R., Hoey T., Warrior R., Levine M. RT Transcriptional regulation of a pair-rule stripe in Drosophila RL Genes Dev. 5:827-839 (1991). RN [17] RA Stanojevic D., Small S., Levine M. RT Regulation of segmentation stripe by overlapping activators RT and repressors in the Drosophila embryo RL Science 254:1385-1387 (1991). XX // AC T00273 XX ID T00273 XX DT 09.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Evi-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; 2.3.2.2.8. XX SZ 1042 AA; 117 kDa (cDNA); 145 kDa (SDS) XX SQ MKSEEDPHEPMAPDIHEERQHRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDLQQ SQ NLESESDLREIHGNQDCKECDRVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIR SQ HQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKH SQ IHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCE SQ GKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGTNRHPAGLTFPTAPGFS SQ FSFPGLFPSGLYHRPPLIPASPPVKGLSSTEQSNKCQSPLLTHPQILPATQDILKALSKH SQ PPVGDNKPVELLPERSSEERPLEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDLESD SQ KEKCKENGKMFKDKVSPLQNLASITNKKEHNNHSVFSASVEEQSAVSGAVNDSIKAIASI SQ AEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPS SQ EVKKLQKGSSESPFDLTTKRKDEKPLTSGPSKPSGTPATSQDQPLDLSMGSRGRASGTKL SQ TEPRKNHVFGEKKGSNMDTRPSSDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYL SQ RPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFSFRAPPNTLPENLLRKG SQ KERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKP SQ FKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESAGAILDDKEDAYFTEIRN SQ FIGNSNHGSQSPRNMEERMNGSHFKDKKALATSQNSDLLDDEEVEDEVLLDEEDEDNDIP SQ GKPRKELGVTRLDEEIPEDDYEEAGALEMSCKASPVRYKEEDYKSGLSALDHIRHFTDSL SQ KMREMEENQYTDAELSSISSSHVPEELKQTLHRKSKSQAYAMMLSLSDKDSLHPTSHSSS SQ NVWHSMARAAAESSAIQSISHV XX SC SwissProt #P14404 XX SF 7 + 3 zinc finger motifs SF acidic region SF phosphorylation XX CP kidney (tubules in the corticomedullary junction); CP ovary (developing oocytes, cytoplasm); in embryos CP also: lung, nasal cavities, heart, limbs (highest 9.5-12.5 d) XX FF involved in myeloid transformation XX MX M00011; V$EVI1_06 MX M00078; V$EVI1_01 MX M00079; V$EVI1_02 MX M00080; V$EVI1_03 MX M00081; V$EVI1_04 MX M00082; V$EVI1_05 XX BS R02305; EVI1$CONS; Quality: 6 XX DR EMBL: M21829; MMZFP(g). DR SwissProt: P14404; EVI1_MOUSE. DR PIR: A31591; A31591. XX RN [1] RA Morishita K., Parker D. S., Mucenski M. L., Jenkins RA N. A., Copeland N. G., Ihle J. N. RT Retroviral activation of a novel gene encoding a zinc RT finger protein in IL-3-dependent myeloid leukemia cell lines RL Cell 54:831-840 (1988). RN [2] RA Matsugi T., Morishita K., Ihle J. N. RT Identification, nuclear localization, and DNA binding RT activity of the zinc finger protein encoded by the RT Evi-1 myeloid transforming gene RL Mol. Cell. Biol. 10:1259-1264 (1990). RN [3] RA Morishita K., Parganas E., Parham D. M., Matsugi T., Ihle J. N. RT The Evi-1 zinc finger myeloid transforming gene is RT normally expressed in the kidney and in developing oocytes RL Oncogene 5:1419-1423 (1990). RN [4] RA Perkins A. S., Fishel R., Jenkins N. A., Copeland N. G. RT Evi-1, a murine zinc finger proto-oncogene, encodes RT a sequence-specific DNA-binding protein RL Mol. Cell. Biol. 11:2665-2674 (1991). RN [5] RA Perkins A. S., Mercer J. A., Jenkins N. A., Copeland N. G. RT Patterns of Evi-1 expression in embryonic and adult RT tissues suggest that Evi-1 plays an important role in mouse development RL Development 111:479-487 (1991). XX // AC T00274 XX ID T00274 XX DT 20.10.92 (created); ewi. DT 09.05.96 (updated); ewi. XX FA Emc XX SY Extramacrochaetae; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0011; HLH; 1.2.8.0.1. XX SZ 199 AA; 22.0 kDa (gene) XX SQ MKSLTAVCQTGASGMPALNASGRIQRHPTHRGDGENAEMKMYLSKLKDLVPFMPKNRKLT SQ KLEIIQHVIDYICDLQTELETHPEMGNFDAAAALTAVNGLHEDEDSDMEDADAEAEAEVD SQ PDVLAQRLNAEQPAKVSSPAARLPLTDRQTPNTLVAPAHPQQHQQQQQLQLQQQQLQSQQ SQ QLSNSLATPQNAEKDSRQS XX SC SwissProt #P18491 XX FT 36 76 helix-loop-helix domain FT 102 122 acidic region (13/21) FT 161 181 glutamine-rich region (16/21) XX SF no DNA-binding basic domain [3], [4]; XX CP adult sensory organs XX FF Achaete-Scute antagonist, participates in sensory FF organ patterning [3], [4], [2]: sensory mother cells FF develop when emc expression is at a minimum [1]; XX DR EMBL: M31902; DMEMC(r). DR EMBL: M31901; DMEMC1(g). DR EMBL: M32636; DMEMCA1(g). DR SwissProt: P18491; EMC_DROME. DR PIR: A34688; A34688. DR PIR: A34689; A34689. DR Flybase: FBgn0000575; emc. XX RN [1] RA Cubas P., Modolell J. RT The extramacrochaetae gene provides information for sensory organ patterning RL EMBO J. 11:3385-3393 (1992). RN [2] RA Van Doren M., Ellis H. M., Posakony J. W. RT The Drosophila extramacrochaetae protein antagonizes RT sequence-specific DNA binding by daughterless/achaete-scute RT protein complexes RL Development 113:245-255 (1991). RN [3] RA Ellis H. M., Spann D. R., Posakony J. W. RT extramacrochaetae, a negative regulator of sensory RT organ development in Drosophila, defines a new class RT of helix-loop-helix proteins RL Cell 61:27-38 (1990). RN [4] RA Garrell J., Modolell J. RT The Drosophila extramacrochaetae locus, an antagonist RT of proneural genes that; like these genes; encodes RT a helix-loop-helix protein RL Cell 61:39-48 (1990). XX // AC T00275 XX ID T00275 XX DT 26.01.93 (created); hse. DT 24.04.95 (updated); ewi. XX FA F-ACT1 XX SY NF-E1 (2); YY1; delta factor; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX FF putative repressor through a serum response element FF by binding competition with SRF; FF decreases during myoblast differentiation XX BS R00034; CHICK$AAC_06; Quality: 5; chick, Gallus gallus BS R02154; FACT1$CONS; Quality: 6 XX RN [1] RA Lee T.-C., Shi Y., Schwartz R. J. RT Displacement of BrdUrd-induced YY1 by serum response RT factor activates skeletal alpha-actin transcription in embryonic myoblasts RL Proc. Natl. Acad. Sci. USA 89:9814-9818 (1992). RN [2] RA Lee T.-C., Chow K.-L., Fang P., Schwartz R. J. RT Activation of skeletal alpha-actin gene transcription: RT the cooperative formation of serum response factor-binding RT complexes over positive cis-acting promoter serum RT response elements displaces a negative-acting nuclear RT factor enriched in replicating a RL Mol. Cell. Biol. 11:5090-5100 (1991). XX // AC T00276 XX ID T00276 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA alpha-factor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO XrpFI (X. laevis), HrpF (human) XX RN [1] RA Hariharan N., Kelley D. E., Perry R. P. RT Equipotent mouse ribosomal protein promoters have RT a similar architecture that includes internal sequence elements RL Genes Dev. 3:1789-1800 (1989). XX // AC T00277 XX ID T00277 XX DT 15.10.92 (created); ewi. XX FA gamma-factor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01832; MOUSE$RPL30_03; Quality: 6; mouse, Mus musculus XX RN [1] RA Hariharan N., Kelley D. E., Perry R. P. RT Equipotent mouse ribosomal protein promoters have RT a similar architecture that includes internal sequence elements RL Genes Dev. 3:1789-1800 (1989). XX // AC T00278 XX ID T00278 XX DT 15.10.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA delta factor XX SY F-ACT1; NF-E1 (2); YY-1; YY1; delta-factor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; . XX SZ 414 AA; 44.6 kDa (cDNA), 60-65 kDa (SDS) XX FT 5 53 acidic region FT 54 65 glycine-rich region FT 71 82 histidine dodecamer FT 298 407 4 Cys2His2 zinc finger motifs XX SF zinc finger domain is essential for DNA-binding XX CP (brain) widespread XX MX M00059; V$YY1_01 MX M00069; V$YY1_02 XX BS R00284; MOUSE$DHFR_04; Quality: 4; mouse, Mus musculus BS R01833; MOUSE$RPL30_04; Quality: 2; mouse, Mus musculus BS R01329; MOUSE$RPL32_04; Quality: 4; mouse, Mus musculus BS R01330; MOUSE$RPL32_05; Quality: 4; mouse, Mus musculus BS R04077; MOUSE$RPL7_01; Quality: 4; mouse, Mus musculus BS R03002; MOUSE$SURF2_02; Quality: 4; mouse, Mus musculus BS R04078; YY1$CONS_01; Quality: 6 BS R04142; YY1$CONS_02; Quality: 6 BS R04143; YY1$CONS_03; Quality: 6 XX DR EMBL: M74590; MMDELTA(r). XX RN [1] RA Atchison M. L., Meyuhas O., Perry R. P. RT Localization of Transcriptional Regulatory Elements RT and Nuclear Factor Binding Sites in Mouse Ribosomal Protein Gene rpL32 RL Mol. Cell. Biol. 9:2067-2074 (1989). RN [2] RA Hariharan N., Kelly D. E., Perry R. P. RT Delta, a transcription factor that binds to downstream RT elements in several polymerase II promoters, is a RT functionally versatile zinc finger protein RL Proc. Natl. Acad. Sci. USA 88:9799-9803 (1991). RN [3] RA Park K., Atchison M. L. RT Isolation of a candidate repressor/activator, NF-E1 RT (YY-1, delta), that binds to the immunoglobulin kappa RT 3 enhancer and the immunoglobulin heavy-chain muE1 site RL Proc. Natl. Acad. Sci. USA 88:9804-9808 (1991). RN [4] RA Hariharan N., Kelley D. E., Perry R. P. RT Equipotent mouse ribosomal protein promoters have RT a similar architecture that includes internal sequence elements RL Genes Dev. 3:1789-1800 (1989). XX // AC T00279 XX ID T00279 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA factor 1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO SRF (human) XX BS R00473; MOUSE$CFOS_02; Quality: 6; mouse, Mus musculus XX RN [1] RA Gilman M. Z., Wilson R. N., Weinberg R. A. RT Multiple Protein-Binding Sites in the 5'-Flanking RT Region Regulate c-fos Expression RL Mol. Cell. Biol. 6:4305-4316 (1986). XX // AC T00280 XX ID T00280 XX DT 15.10.92 (created); ewi. XX FA factor 2 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00476; MOUSE$CFOS_05; Quality: 6; mouse, Mus musculus BS R00477; MOUSE$CFOS_06; Quality: 6; mouse, Mus musculus XX RN [1] RA Gilman M. Z., Wilson R. N., Weinberg R. A. RT Multiple Protein-Binding Sites in the 5'-Flanking RT Region Regulate c-fos Expression RL Mol. Cell. Biol. 6:4305-4316 (1986). XX // AC T00281 XX ID T00281 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA factor 3 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO Sp1 (human) XX BS R00478; MOUSE$CFOS_07; Quality: 6; mouse, Mus musculus XX RN [1] RA Gilman M. Z., Wilson R. N., Weinberg R. A. RT Multiple Protein-Binding Sites in the 5'-Flanking RT Region Regulate c-fos Expression RL Mol. Cell. Biol. 6:4305-4316 (1986). XX // AC T00282 XX ID T00282 XX DT 16.04.93 (created); ewi. XX FA factor 2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF overlapping binding site with YY1 at the AAV P5 promoter XX BS R03176; AAV$P5_03; Quality: 6; AAV, adeno-associated virus XX RN [1] RA Shi Y., Seto E., Chang L.-S., Shenk T. RT Transcriptional repression by YY1, a human GLI-Krueppel-related RT protein, and relief of repression by adenovirus E1A protein RL Cell 67:377-388 (1991). XX // AC T00283 XX ID T00283 XX DT 15.10.92 (created); ewi. XX FA factor delta XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01833; MOUSE$RPL30_04; Quality: 6; mouse, Mus musculus BS R01329; MOUSE$RPL32_04; Quality: 6; mouse, Mus musculus XX RN [1] RA Atchison M. L., Meyuhas O., Perry R. P. RT Localization of Transcriptional Regulatory Elements RT and Nuclear Factor Binding Sites in Mouse Ribosomal Protein Gene rpL32 RL Mol. Cell. Biol. 9:2067-2074 (1989). XX // AC T00284 XX ID T00284 XX DT 15.10.92 (created); ewi. XX FA factor B1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00545; MOUSE$BMG_06; Quality: 6; mouse, Mus musculus BS R00546; MOUSE$BMG_07; Quality: 6; mouse, Mus musculus XX RN [1] RA Galson D. L., Housman D. E. RT Detection of Two Tissue-Specific DNA-Binding Proteins RT with Affinity for Sites in the Mouse beta-Globin Intervening Sequence 2 RL Mol. Cell. Biol. 8:381-392 (1988). XX // AC T00285 XX ID T00285 XX DT 15.10.92 (created); ewi. XX FA factor B2 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00544; MOUSE$BMG_05; Quality: 6; mouse, Mus musculus XX RN [1] RA Galson D. L., Housman D. E. RT Detection of Two Tissue-Specific DNA-Binding Proteins RT with Affinity for Sites in the Mouse beta-Globin Intervening Sequence 2 RL Mol. Cell. Biol. 8:381-392 (1988). XX // AC T00286 XX ID T00286 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA factor i XX SY F-i; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO TFIID XX BS R01127; MMTV$MMTV_29; Quality: 6; MMTV, mouse mammary tumor virus BS R01128; MMTV$MMTV_30; Quality: 6; MMTV, mouse mammary tumor virus BS R01129; MMTV$MMTV_31; Quality: 6; MMTV, mouse mammary tumor virus XX RN [1] RA Cordingley M. G., Hager G. L. RT Binding of multiple factors to the MMTV promoter in RT crude and fractionated nuclear extracts RL Nucleic Acids Res. 16:609-628 (1988). RN [2] RA Cordingley M. G., Riegel A. T., Hager G. L. RT Steroid-Dependent Interaction of Transcription Factors RT with the Inducible Promoter of Mouse Mammary Tumor Virus In Vivo RL Cell 48:261-270 (1987). XX // AC T00287 XX ID T00287 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA f(alpha)-f(epsilon) XX SY factor alpha; factor beta; factor epsilon; factor gamma; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01830; MOUSE$RPL30_01; Quality: 6; mouse, Mus musculus BS R01831; MOUSE$RPL30_02; Quality: 6; mouse, Mus musculus BS R01326; MOUSE$RPL32_01; Quality: 6; mouse, Mus musculus BS R01327; MOUSE$RPL32_02; Quality: 6; mouse, Mus musculus BS R01328; MOUSE$RPL32_03; Quality: 6; mouse, Mus musculus BS R01330; MOUSE$RPL32_05; Quality: 6; mouse, Mus musculus XX RN [1] RA Atchison M. L., Meyuhas O., Perry R. P. RT Localization of Transcriptional Regulatory Elements RT and Nuclear Factor Binding Sites in Mouse Ribosomal Protein Gene rpL32 RL Mol. Cell. Biol. 9:2067-2074 (1989). XX // AC T00288 XX ID T00288 XX DT 14.12.92 (created); ewi. XX FA FBF-A1 XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; OC lepidoptera; bombycoidea; bombycidae XX CP ubiquitous XX BS R02719; BOMMO$F_08; Quality: 6; silk moth, Bombyx mori XX RN [1] RA Hui C.-C., Matsuno K., Suzuki Y. RT Fibroin Gene Promoter Contains a Cluster of Homeodomain RT Binding Sites that Interact with Three Silk Gland Factors RL J. Mol. Biol. 213:651-670 (1990). XX // AC T00289 XX ID T00289 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA f-EBP XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO TCF, 62K protein [2]; XX SZ 62 kDa XX CP (HeLa) XX RN [1] RA Prywes R., Roeder R. G. RT Purification of the c-fos enhancer-binding protein RL Mol. Cell. Biol. 7:3482-3489 (1987). RN [2] RA Ryan jr. W. A., Franza Jr. B. R., Gilman M. Z. RT Two distinct cellular phospholipoproteins bind to RT the c-fos serum response element RL EMBO J. 8:1785-1792 (1989). XX // AC T00290 XX ID T00290 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA FLV-1 XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX HO PEA-2 XX BS R01660; FELV$FELV_05; Quality: 6; FeLV, feline leukemia virus XX RN [1] RA Fulton R., Plumb M., Shield L., Neil J. C. RT Structural Diversity and Nuclear Protein Binding Sites RT in the Long Terminal Repeats of Feline Leukemia Virus RL J. Virol. 64:1675-1682 (1990). XX // AC T00291 XX ID T00291 XX DT 15.10.92 (created); ewi. XX FA Fos-B XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.1.2.3. XX SZ 40 kDa XX IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. XX RN [1] RA Schuermann M., Jooss K., Mueller R. RT fosB is a transforming gene encoding a transcriptional activator RL Oncogene 6:567-576 (1991). RN [2] RA Dobrzanski P., Noguchi T., Kovary K., Rizzo C. A., Lazo P. S., Bravo R. RT Both products of the fosB gene, FosB and its short RT form, FosB/SF, are transcriptional activators in fibroblasts RL Mol. Cell. Biol. 11:5470-5478 (1991). RN [3] RA Nakabeppu Y., Nathans D. RT A naturally occurring truncated form of FosB that RT inhibits Fos/Jun transcriptional activity RL Cell 64:751-759 (1991). RN [4] RA Yen J., Wisdom R. M., Tratner I., Verma I. M. RT An alternative spliced form of FosB is a negative RT regulator of transcriptional activation and transformation by Fos proteins RL Proc. Natl. Acad. Sci. USA 88:5077-5081 (1991). RN [5] RA Wisdom R., Verma I. M. RT Proto-oncogene FosB: the amino terminus encodes a RT regulatory function required for transformation RL Mol. Cell. Biol. 13:2635-2643 (1993). RN [6] RA Nakabeppu Y., Oda S., Sekiguchi M. RT Proliferative activation of quiescent Rat-1A cells by deltaFosB RL Mol. Cell. Biol. 13:4157-4166 (1993). RN [7] RA Wisdom R., Verma I. M. RT Transformation by Fos proteins requires a C-terminal transactivation domain RL Mol. Cell. Biol. 13:7429-7438 (1993). RN [8] RA Jooss K. U., Funk M., Mueller R. RT An autonomous N-terminal transactivation domain in RT Fos protein plays a crucial role in transformation RL EMBO J. 13:1467-1475 (1994). RN [9] RA Metz R., Kouzarides T., Bravo R. RT A C-terminal domain in FosB, absent in FosB/SF and RT Fra-1, which is able to interact with the TATA binding RT protein, ir required for altered cell growth RL EMBO J. 13:3832-3842 (1994). RN [10] RA Mumberg D., Lucibello F. C., Schuermann M., Mueller R. RT Alternative splicing of fosB transcripts results in RT differentially expressed mRNAs encoding functionally antagonistic proteins RL Genes Dev. 5:1212-1223 (1991). RN [11] RA Wisdom R., Verma I. M. RT Transformation by FosB requires a trans-activation RT domain missing in FosB2 that can be substituted by RT heterologous activation domains RL Genes Dev. 6:667-675 (1992). RN [12] RA Kovary K., Bravo R. RT Existence of different Fos/Jun complexes during the RT G0-to-G1 transition and during exponential growth RT in mouse fibroblasts: differential role of Fos proteins RL Mol. Cell. Biol. 12:5015-5023 (1992). RN [13] RA Zerial M., Toschi L., Ryseck R.-P., Schuermann M., Mueller R., Bravo R. RT The product of a novel growth factor activated gene, RT fos B, interacts with JUN proteins enhancing their DNA binding activity RL EMBO J. 8:805-813 (1989). XX // AC T00292 XX ID T00292 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA FraI XX SY Fra-1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.1.2.4. XX SF phosphorylation XX IN T00051; ATF; human, Homo sapiens. IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T00436; JunB; mouse, Mus musculus. IN T00437; Jun-D; mouse, Mus musculus. IN T01303; CREB-2; human, Homo sapiens. XX BS R01037; HS$MT2A_08; Quality: 6; human, Homo sapiens XX DR Compel: C00074 DR Compel: C00105 XX RN [1] RA Cohen D. R., Curran T. RT fra-1: a serum-inducible, cellular immediate-early RT gene that encodes a Fos-related antigen RL Mol. Cell. Biol. 8:2063-2069 (1988). RN [2] RA Kouzarides T., Ziff E. RT The role of the leucine zipper in the fos-jun interaction RL Nature 336:646-651 (1988). RN [3] RA Wisdom R., Verma I. M. RT Transformation by Fos proteins requires a C-terminal transactivation domain RL Mol. Cell. Biol. 13:7429-7438 (1993). RN [4] RA Kovary K., Bravo R. RT Existence of different Fos/Jun complexes during the RT G0-to-G1 transition and during exponential growth RT in mouse fibroblasts: differential role of Fos proteins RL Mol. Cell. Biol. 12:5015-5023 (1992). RN [5] RA Metz R., Kouzarides T., Bravo R. RT A C-terminal domain in FosB, absent in FosB/SF and RT Fra-1, which is able to interact with the TATA binding RT protein, ir required for altered cell growth RL EMBO J. 13:3832-3842 (1994). RN [6] RA Kerppola T. K., Curran T. RT Selective DNA bending by a variety of bZIP proteins RL Mol. Cell. Biol. 13:5479-5489 (1993). RN [7] RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., RA Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B. RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB RL Mol. Cell. Biol. 13:1911-1919 (1993). RN [8] RA Cohen D. R., Ferreira P. C. P., Gentz R., Franza B. R., Curran T. RT The product of a fos-related gene, fra-1, binds cooperatively RT to the AP-1 site with Jun: transcription factor AP-1 RT is comprised of multiple protein complexes RL Genes Dev. 3:172-184 (1989). XX // AC T00293 XX ID T00293 XX DT 26.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA FRG Y1 XX OS clawed frog, Xenopus laevis OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CL C0019; protamine-like; 1.8.1.0.3. XX SZ 303 AA; 34.6 kDa (cDNA); 56 kDa (SDS) XX SQ MSSEVETQQQQPDALEGKAGQEPAATVGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKE SQ DVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPEGVPVQGSKYAADR SQ NHYRRYPRRRGPPRNYQQNYQNNESGEKAEENESAPEGDDSNQQRPYHRRRFPPYYSRRP SQ YGRRPQYSNAPVQGEEAEGADSQGTDEQGRPARQNMYRGFRPRFRRGPPRQRQPREEGNE SQ EDKENQGDETQSQPPPQRRYRRNFNYRRRRPENPKSQDGKETKAAETSAENTSTPEAEQG SQ GAE XX SC SwissProt #P21573 XX FT 30 106 cold shock region FT 120 134 basic region FT 144 160 acidic region FT 165 184 basic region FT 195 207 acidic region FT 210 235 basic region FT 236 249 acidic region FT 258 270 basic region XX SF basic clusters, acidic region XX CP ubiquitous XX BS R02868; AS$FRGY_01; Quality: 2 BS R02867; XENLA$HSP70_01; Quality: 6; clawed frog, Xenopus laevis XX DR EMBL: M59453; XLFRGY1(r). DR SwissProt: P21573; YB1_XENLA. DR PIR: A38274; A38274. XX RN [1] RA Wolffe A. P., Tafuri S. R., Ranjan M., Familari M. RT The Y-box factors: a family of nucleic acid binding RT protein conserved from Escherichia coli to man RL New Biologist 4:250-298 (1992). RN [2] RA Tafuri S. R., Wolffe A. P. RT DNA binding, multimerization, and transcription stimulation RT by the Xenopus Y box proteins in vitro RL New Biologist 4:349-359 (1992). RN [3] RA Tafuri S. R., Wolffe A. P. RT Xenopus Y-box transcription factors: molecular cloning, RT functional analysis, and developmental regulation RL Proc. Natl. Acad. Sci. USA 87:9028-9032 (1990). XX // AC T00294 XX ID T00294 XX DT 26.01.93 (created); ewi. DT 07.01.97 (updated); hiwi. XX FA FRG Y2 XX SY mrnp4; XX OS clawed frog, Xenopus laevis OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CL C0019; protamine-like; 1.8.1.0.4. XX SZ 336 AA; 37.2 kDa (cDNA); 60 kDa (SDS); 56 kDa (SDS) XX SQ MSEAEAQEPEPVPQPESEPEIQKPGIAAARNQANKKVLATQVQGTVKWFNVRNGYGFINR SQ NDTKEDVFVHQTAIKKNNPRKFLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVKGSR SQ FAPNRRRFRRRFYRPRADTAGESGGEGVSPEQMSEGERGEETSPQQRPQRRRPPPFFYRR SQ RFRRGPRPNNQQNQGAEVTEQSENKDPVAPTSEALASGDDPQRPPPRRFRQRFRRPFRPR SQ PAPQQTPEGGDGETKAESGEDPRPEPQRQRNRPYVQRRRRQGATQVAATAQGEGKAEPTQ SQ HPASEEGTPSDSPTDDGAPVQSSAPDPGIADTPAPE XX SC r XX FT 167 187 arginine-rich region (10/21) FT 35 111 cold shock region FT 125 136 basic region FT 142 161 acidic region FT 144 336 essential for multimerization FT 197 220 acidic region FT 223 240 basic region FT 248 261 acidic region FT 268 280 basic region XX SF basic clusters, acidic region XX CP testis, immature oocytes XX BS R02868; AS$FRGY_01; Quality: 2 BS R02867; XENLA$HSP70_01; Quality: 6; clawed frog, Xenopus laevis XX DR EMBL: M59454; XLFRGY2(r). DR SwissProt: P21574; YB2_XENLA. DR PIR: B38274; B38274. XX RN [1] RA Wolffe A. P., Tafuri S. R., Ranjan M., Familari M. RT The Y-box factors: a family of nucleic acid binding RT protein conserved from Escherichia coli to man RL New Biologist 4:250-298 (1992). RN [2] RA Bouvet P., Wolffe A. P. RT A role for transcription and FRGY2 in masking maternal RT mRNA within Xenopus oocytes RL Cell 77:934-941 (1994). RN [3] RA Deschamps S., Viel A., Garrigos M., Denis H., le Maire M. RT mRNP4, a major mRNA-binding protein from Xenopus oocytes RT is identical to transcription factor FRG Y2 RL J. Biol. Chem. 267:13799-13802 (1992). RN [4] RA Tafuri S. R., Wolffe A. P. RT DNA binding, multimerization, and transcription stimulation RT by the Xenopus Y box proteins in vitro RL New Biologist 4:349-359 (1992). RN [5] RA Tafuri S. R., Wolffe A. P. RT Xenopus Y-box transcription factors: molecular cloning, RT functional analysis, and developmental regulation RL Proc. Natl. Acad. Sci. USA 87:9028-9032 (1990). XX // AC T00295 XX ID T00295 XX DT 15.10.92 (created); ewi. DT 27.01.97 (updated); ewi. XX FA Ftz XX SY fushi tarazu; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0006; homeo; 3.1.1.2.6. XX SZ 413 AA; 46.9 kDa (cDNA), 60 kDa (SDS) XX SQ MATTNSQSHYSYADNMNMYNMYHPHSLPPTYYDNSGSNAYYQNTSNYHSYQGYYPQESYS SQ ESCYYYNNQEQVTTQTVPPVQPTTPPPKATKRKAEDDAASIIAAVEERPSTLRALLTNPV SQ KKLKYTPDYFYTTVEQVKKAPAVTTKVTASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQ SQ SQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAPNGAGD SQ FNWSHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQ SQ IKIWFQNRRMKSKKDRTLDSSPEHCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTT SQ AAYPAYSHSHSHGYGLLNDYPQQQTHQQYDAYPQQYQQQCSYQQHPQDLYHLS XX SC SwissProt #P02835 XX FT 257 316 homeo domain XX SF overlapping DNA-binding specificity with En [17], [10]; SF Ftz(Q50K) mutant exhibits altered, Bcd-like binding specificity [20]; SF isolated DNA-binding domain binds to an optimized SF binding site as a monomer with KD = 0.25 pM [21]; SF helix-turn-helix structure of the homeo domain confirmed SF by NMR studies: 3 alpha-helices with 6 AA loop betwenn SF helix I and II, and a 3 AA turn between helices II and III [7]; SF helix III serves as main DNA-contacting moiety (by homology with Antp) [7]; SF when interacting with Prd, even homeo domain-deleted SF Ftz can regulate segmentation and gene expression [8]; XX CP even parasegments [25], [12]; XX FF activator [10], [11], [1], [6]; FF pair-rule gene product, mutations of which may cause FF loss of half of larval segments [9]; FF may be bound nearly uniformly throughout the length FF of its target genes: first binding to a high-affinity FF site may direct additional Ftz molecules to moderate FF or low affinity binding sites [4]; FF 3 distinct phases of expression: at 3-4h stage within FF seven stripes representing the even-numbered parasegments [25], [5]; FF at 8-10h stages within some neuronal precursor cells [25], [12]; FF 12-15h embryos: small ring of Ftz expression appears in a dorsal zone [25]; FF subject to positive autoregulation [24], [14]; FF antagonistic action with En [10]; FF posttranslational modification [25]; XX IN T00699; Prd; fruit fly, Drosophila melanogaster. XX MX M00020; I$FTZ_01 XX BS R02449; AS$FTZ_01; Quality: 6 BS R02450; AS$FTZ_02; Quality: 6 BS R02451; AS$FTZ_03; Quality: 6 BS R02511; AS$FTZ_04; Quality: 6 BS R02512; AS$FTZ_05; Quality: 6 BS R02513; AS$FTZ_06; Quality: 6 BS R02514; AS$FTZ_07; Quality: 6 BS R02515; AS$FTZ_08; Quality: 6 BS R02516; AS$FTZ_09; Quality: 6 BS R02517; AS$FTZ_10; Quality: 6 BS R02518; AS$FTZ_11; Quality: 6 BS R02519; AS$FTZ_12; Quality: 6 BS R02520; AS$FTZ_13; Quality: 6 BS R02521; AS$FTZ_14; Quality: 6 BS R02522; AS$FTZ_15; Quality: 6 BS R02523; AS$FTZ_16; Quality: 6 BS R02524; AS$FTZ_17; Quality: 6 BS R02525; AS$FTZ_18; Quality: 6 BS R02526; AS$FTZ_19; Quality: 6 BS R02527; AS$FTZ_20; Quality: 6 BS R02528; AS$FTZ_21; Quality: 6 BS R02529; AS$FTZ_22; Quality: 6 BS R02530; AS$FTZ_23; Quality: 6 BS R02531; AS$FTZ_24; Quality: 6 BS R02532; AS$FTZ_25; Quality: 6 BS R02533; AS$FTZ_26; Quality: 6 BS R02534; AS$FTZ_27; Quality: 6 BS R02535; AS$FTZ_28; Quality: 6 BS R02536; AS$FTZ_29; Quality: 6 BS R02537; AS$FTZ_30; Quality: 6 BS R02538; AS$FTZ_31; Quality: 6 BS R02539; AS$FTZ_32; Quality: 6 BS R02540; AS$FTZ_33; Quality: 6 BS R02541; AS$FTZ_34; Quality: 6 BS R02542; AS$FTZ_35; Quality: 6 BS R02543; AS$FTZ_36; Quality: 6 BS R02544; AS$FTZ_37; Quality: 6 BS R02545; AS$FTZ_38; Quality: 6 BS R02546; AS$FTZ_39; Quality: 6 BS R02547; AS$FTZ_40; Quality: 6 BS R02548; AS$FTZ_41; Quality: 6 BS R02549; AS$FTZ_42; Quality: 6 BS R02550; AS$FTZ_43; Quality: 6 BS R02551; AS$FTZ_44; Quality: 6 BS R02552; AS$FTZ_45; Quality: 6 BS R02553; AS$FTZ_46; Quality: 6 BS R01669; AS$FTZ_47; Quality: 2 BS R02510; DROME$ANTP_12; Quality: 2; fruit fly, Drosophila melanogaster BS R00411; DROME$EN_01; Quality: 2; fruit fly, Drosophila melanogaster BS R00412; DROME$EN_02; Quality: 2; fruit fly, Drosophila melanogaster BS R00419; DROME$EVE_02; Quality: 6; fruit fly, Drosophila melanogaster BS R02351; DROME$FTZ_08; Quality: 6; fruit fly, Drosophila melanogaster BS R02352; DROME$FTZ_09; Quality: 6; fruit fly, Drosophila melanogaster BS R02353; DROME$FTZ_10; Quality: 6; fruit fly, Drosophila melanogaster BS R02354; DROME$FTZ_11; Quality: 6; fruit fly, Drosophila melanogaster BS R02355; DROME$FTZ_12; Quality: 6; fruit fly, Drosophila melanogaster BS R02356; DROME$FTZ_13; Quality: 6; fruit fly, Drosophila melanogaster BS R02357; DROME$FTZ_14; Quality: 6; fruit fly, Drosophila melanogaster BS R02358; DROME$FTZ_15; Quality: 6; fruit fly, Drosophila melanogaster BS R02359; DROME$FTZ_16; Quality: 6; fruit fly, Drosophila melanogaster BS R02360; DROME$FTZ_17; Quality: 6; fruit fly, Drosophila melanogaster BS R02361; DROME$FTZ_18; Quality: 6; fruit fly, Drosophila melanogaster BS R02362; DROME$FTZ_19; Quality: 6; fruit fly, Drosophila melanogaster BS R02363; DROME$FTZ_20; Quality: 6; fruit fly, Drosophila melanogaster BS R02364; DROME$FTZ_21; Quality: 6; fruit fly, Drosophila melanogaster BS R02365; DROME$FTZ_22; Quality: 6; fruit fly, Drosophila melanogaster BS R02366; DROME$FTZ_23; Quality: 6; fruit fly, Drosophila melanogaster BS R02367; DROME$FTZ_24; Quality: 6; fruit fly, Drosophila melanogaster BS R02368; DROME$FTZ_25; Quality: 6; fruit fly, Drosophila melanogaster BS R02369; DROME$FTZ_26; Quality: 6; fruit fly, Drosophila melanogaster BS R02370; DROME$FTZ_27; Quality: 6; fruit fly, Drosophila melanogaster BS R02371; DROME$FTZ_28; Quality: 6; fruit fly, Drosophila melanogaster BS R03867; RAT$45SRRNA_01; Quality: 6; rat, Rattus norvegicus XX DR EMBL: K01947; DMANTC1(g). DR EMBL: X00854; DMFTZ1(g). DR SwissProt: P02835; HMFT_DROME. DR PIR: A03320; WJFFFT. DR Flybase: FBgn0001077; ftz. DR PDB: 1ftz; FUSHI TARAZU PROTEIN (HOMEODOMAIN) (NMR, 20 STRUCTURES) D. MELANOGASTER. XX RN [1] RA Ohkuma Y., Horikoshi M., Roeder R. G., Desplan C. RT Binding site-dependent direct activation and repression RT of in vitro transcription by Drosophila homeodomain proteins RL Cell 61:475-484 (1990). RN [2] RA McGinnis W., Garber R. L., Wirz J., Kuroiwa A., Gehring W. J. RT A homologous protein-coding sequence in Drosophila RT homeotic genes and its conservation in other metazoans RL Cell 37:403-408 (1984). RN [3] RA Scott M. P., Weiner A. RT Structural relationships among genes that control RT develop-ment: Sequence homology between the Antennapedia, RT Ultrabithorax, and fushi tarazu loci of Droso-phila RL Proc. Natl. Acad. Sci. USA 81:4115-4119 (1984). RN [4] RA Walter J., Dever C. A., Biggin M. D. RT Two homeo domain proteins bind with similar specificity RT to a wide range of DNA sites in Drosophila embryos RL Genes Dev. 8:1678-1692 (1994). RN [5] RA Lawrence P., Johnston P., Macdonald P., Struhl G. RT Borbders of parasegments in Drosophila are delimited RT by the fushi tarazu and even-skipped genes RL Nature 328:440-442 (1987). RN [6] RA Mueller J., Bienz M. RT Sharp anterior boundary of homeotic gene expression RT conferred by the fushi tarazu protein RL EMBO J. 11:3653-3661 (1992). RN [7] RA Qian Y. Q., Furukubo-Tokunaga K., Resendez-Perez D., RA Mueller M., Gehring W. J., Wuethrich K. RT Nuclear magnetic resonance solution structure of the RT fushi tarazu homeodomain from Drosophila and comparison RT with the Antennapedia homeodomain RL J. Mol. Biol. 238:333-345 (1994). RN [8] RA Copeland J. W. R., Nasladka A., Dietrich B. H., Krause H. M. RT Patterning of the Drosophila embryo by a homeodomain-deleted Ftz polypeptide RL Nature 379:162-165 (1996). RN [9] RA Laughon A., Scott M. P. RT Sequence of a Drosophila segmentation gene: protein RT structure homology with DNA-binding proteins RL Nature 310:25-31 (1984). RN [10] RA Jaynes J. B., Farrell P. H. RT Activation and repression of transcription by homoeodomain-containing RT proteins that bind a common site RL Nature 336:744-749 (1988). RN [11] RA Fitzpatrick V. D., Ingles C. J. RT The Drosophila fushi tarazu polypeptide is a DNA-binding RT transcriptional activator in yeast cells RL Nature 337:666-668 (1989). RN [12] RA Zhao J. J., Pick L. RT Generating loss-of-function phenotypes of the fushi RT tarazu gene with a targeted ribozyme in Drosophila RL Nature 365:448-451 (1993). RN [13] RA Schier A. F., Gehring W. J. RT Functional specificity of the homeodomain protein RT fushi tarazu: The role of DNA-binding specificity in vivo RL Proc. Natl. Acad. Sci. USA 90:1450-1454 (1993). RN [14] RA Schier A. F., Gehring W. J. RT Analysis of a fushi tarazu autoregulatory element: RT multiple sequence elements contribute to enhancer activity RL EMBO J. 12:1111-1119 (1993). RN [15] RA Krause H. M., Gehring W. J. RT Stage-specific phosphorylation of the fushi tarazu RT protein during Drosophila development RL EMBO J. 8:1197-1204 (1989). RN [16] RA Qian Y. Q., Furukubo-Tokunaga K., Resendez-Perez D., RA Mueller M., Gehring W. J., Wuethrich K. RT Nuclear magnetic resonance solution structure of the RT fushi tarazu homeodomain from Drosophila and comparison RT with the Antennapedia homeodomain. RL J. Mol. Biol. 238:333-345 (1994). RN [17] RA Desplan C., Theis J., O'Farrell P. H. RT The sequence specificity of homeodomain-DNA interaction RL Cell 54:1081-1090 (1988). RN [18] RA Treisman J., Goenczy P., Vashishta M., Harris E., Desplan C. RT A single amino acid can determine the DNA binding RT specificity of homeodomain proteins RL Cell 59:553-562 (1989). RN [19] RA Ueda H., Sonoda S., Brown J. L., Scott M. P., Wu C. RT A sequence-specific DNA-binding protein that activates RT fushi tarazu segmentation gene expression RL Genes Dev. 4:624-635 (1990). RN [20] RA Percival-Smith A., Mueller M., Affolter M., Gehring W. J. RT The interaction with DNA of wild-type and mutant fushi tarazu homeodomains RL EMBO J. 9:3967-3974 (1990). RN [21] RA Florence B., Handrow R., Laughon A. RT DNA-binding specificity of th fushi tarazu homeodomain RL Mol. Cell. Biol. 11:3613-3623 (1991). RN [22] RA Topol J., Dearolf C. R., Prakash K., Parker C. S. RT Synthetic oligonucleotides recreate Drosophila fushi RT tarazu zebra-stripe expression RL Genes Dev. 5:855-867 (1991). RN [23] RA Morrissey D., Askew D., Raj L., Weir M. RT Functional dissection of the paired segmentation gene in Drosophila embryos RL Genes Dev. 5:1684-1696 (1991). RN [24] RA Schier A. F., Gehring W. J. RT Direct homeodomain-DNA interaction in the autoregulation RT of the fushi tarazu gene RL Nature 356:804-807 (1992). RN [25] RA Krause H. M., Klemenz R., Gehring W. J. RT Expression, modification, and localization of the RT fushi tarazu protein in Drosophila embryos RL Genes Dev. 2:1021-1036 (1988). XX // AC T00296 XX ID T00296 XX DT 21.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA FTZ-F1 XX SY BmFTZ-F1 (B.mori); DEP1; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX HO ELP (mouse) XX CL C0002; CC (rec); . XX SZ 1043 AA; 110 kDa (cDNA), 95 kDa (SDS) XX SQ MDTFNVPMLAESSNTNYATEATSNHHHLQHQHQQQHSHQQQQQQQQQLLMPHHHKDQMLA SQ AGSSPMLPFYSHLQLQQKDATATIGPAAAAAAVEAATTSANADNFSSLQTIDASQLDGGI SQ SLSGLCDRFFVASPNPHSNSNMTLMGTATAATTTTTNNNNNNNTNNNNNNNVEAKTVRPS SQ NGNSVIIESVTMPSFANILFPTHRSANECIDPALLQKNPQNPNGNNSSIIVPPVEYHQLK SQ PLEVNSSTSVSTSNFLSSTTAQLLDFEVQVGKDDGHISTTTTTGPGSGSASGSGSGSGSG SQ SGSIASTIGTATPTTTTSMSNTANPTRSSLHSIEELAASSCAPRAASPNSNHTSSASTTP SQ QQQQQQQHHMQSGNHSGSNLSSDDESMSEDEFGLEIDDNGGYQDTTSSHSQQSGGGGGGG SQ GGNLLNGSSGGSSAGGGYMLLPQAASSSGNNGNPNAGHMSSGSVGNGSGGAGNGGAGGNS SQ GPGNPMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQN SQ KKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDR SQ ARKLQVMRQRQLALQALRNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPD SQ SSPSPIAIALGQVNASTGGVIATPMNAGTGGSGGGGLNGPSSVGNGNSSNGSSNGNNNSS SQ TGNGTSGGGGGNNAGGGGGGTNSNDGLHRNGGNDSSSCHEAGIGSLQNTADSKLCFDSGT SQ HPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELLMCKVL SQ DQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQ SQ VFNLMSLGLLGVPQPGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPSVRGIVNRKTVSE SQ GHDNVQAALLDYTLTCYPSVNDKFRGLVNILPEIHAMAVRGEDHLITCTPSTVPAVRPPK SQ RCSWRCCTPSARDRGRENVTRNT XX SC SwissProt #P33244 XX FT 579 608 FTZ-F1 box XX CP (late embryos) XX FF implicated in ftz transcription, especially in stripes 1, 2, 3, and 6; FF FTZ-F1 box is involved in high-affinity binding to FF DNA in addition to the zinc fingers XX BS R04280; DROME$ADH_34; Quality: 3; fruit fly, Drosophila melanogaster BS R00485; DROME$FTZ_05; Quality: 2; fruit fly, Drosophila melanogaster XX DR EMBL: M63711; DMFTZF1A(r). DR SwissProt: P33244; FTF1_DROME. DR Flybase: FBgn0001078; ftz-f1. XX RN [1] RA Lavorgna G., Ueda H., Clos J., Wu C. RT FTZ-F1, a steroid hormone receptor-like protein implicated RT in the activation of fushi tarazu RL Science 252:848-851 (1991). RN [2] RA Ueda H., Sun G.-C., Murata T., Hirose S. RT A novel DNA-binding motif abuts the zinc-finger domain RT of insect nuclear hormone receptor FTZ-F1 and mouse RT embryonal long terminal repeat-binding protein RL Mol. Cell. Biol. 12:5667-5672 (1992). RN [3] RA Ayer S., Benyajati C. RT The binding site of a steroid hormone receptor-like RT protein within the Drosophila Adh adult enhancer is RT required for high levels of tissue-specific alcohol dehydrogenase expression RL Mol. Cell. Biol. 12:661- 673 (1992). RN [4] RA Ueda H., Sonoda S., Brown J. L., Scott M. P., Wu C. RT A sequence-specific DNA-binding protein that activates RT fushi tarazu segmentation gene expression RL Genes Dev. 4:624-635 (1990). XX // AC T00297 XX ID T00297 XX DT 20.11.92 (created); ewi. XX FA GA-BF XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX FF may be required for induction and maximal expression FF of pyrimidine biosynthetic genes XX BS R02408; Y$URA3_02; Quality: 5; yeast, Saccharomyces cerevisiae BS R02409; Y$URA3_03; Quality: 5; yeast, Saccharomyces cerevisiae BS R02410; Y$URA3_04; Quality: 5; yeast, Saccharomyces cerevisiae XX RN [1] RA Roy A., Exinger F., Losson R. RT cis- and trans-acting regulatory elements of the yeast URA3 promoter RL Mol. Cell. Biol. 10:5257-5270 (1990). XX // AC T00298 XX ID T00298 XX DT 27.10.92 (created); ewi. DT 07.02.97 (updated); ewi. XX FA GABP XX SY GA binding protein; NRF-2; nuclear respiratory factor 1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0016; ETS; 3.5.2.0.12. XX SZ 454 AA (alpha); 382 AA (beta1); 347 AA (beta2); 170 SZ kDa, 104 kDa (GF, sedim.) [2]; XX SF two subunits: alpha (ets class) + beta (two variants) XX CP abundant in thymus; kidney, liver, muscle; much less CP in uterus, testis, brain, spleen, gut XX FF might interact with membrane-bound proteins through FF some repeats in the beta subunit XX BS R01837; HSV1$IE3_11; Quality: 2; HSV-1, herpes simplex virus type 1 XX DR EMBL: M74515; MMGAA(r). DR EMBL: M74516; MMGAB(r). DR EMBL: M74517; MMGAC(r). DR SwissProt: Q00422; GABA_MOUSE. DR SwissProt: Q00420; GABB_MOUSE. DR SwissProt: Q00421; GABC_MOUSE. DR PIR: A40858; A40858. DR PIR: B40858; B40858. DR PIR: C40858; C40858. XX RN [1] RA LaMarco K., Thompson C. C., Byers B. P., Walton E. M., McKnight S. L. RT Identification of Ets- and Notch-related subunits in GA binding proteins RL Science 253:789-792 (1991). RN [2] RA Thompson C. C., Brown T. A., McKnight S. L. RT Convergence of Ets- and Notch-related structural motifs RT in a heteromeric DNA binding complex RL Science 253:762-768 (1991). XX // AC T00299 XX ID T00299 XX DT 24.03.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GADD 153 XX SY CHOP-10 (mouse); XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX CL C0008; bZIP; 1.1.3.0.6. XX SZ 168 AA; 19 kDa (cDNA) XX SQ MAAESLPFTLETVSSWELEAWYEDLQEVLSSDENGGPYSSSLGNEEGESKTFTTLDPASL SQ AWLTEEPGPAEVTSSSQSPRSPDSSQSCMAQEEEEDQGRTRKRKQSGQCPARGTGKQRMK SQ EKEQENERKVAQLAEENERLKQEIERLTREVEATRPGSDRPHVNLQQV XX SC SwissProt #P14607 XX FT 99 129 variant basic region FT 133 154 variant leucine zipper (L3T) XX CP liver enriched XX FF induced during growth arrest XX MX M00249; V$CHOP_01 XX DR EMBL: M29238; CSGADD(r). DR SwissProt: P14607; CHOP_CRISP. DR PIR: A34096; A34096. XX RN [1] RA Fornace A. J., jr. -, Nebert D. W., Hollander M. C., RA Luethy J. D., Papathanasiou M., Fargnoli J., Holbrook N. J. RT Mammalian genes coordinately regulated by growth arrest RT signals and DNA-damaging agents RL Mol. Cell. Biol. 9:4196-4203 (1989). XX // AC T00300 XX ID T00300 XX DT 26.01.93 (created); hse. DT 19.10.94 (updated); hwi; ewi. XX FA GAF XX SY gamma-activated factor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF similar to AAF; FF induced by interferon-gamma (4h), inhibited by H7 or 2-AP XX BS R02155; GAF$CONS; Quality: 6 BS R03064; HS$GBP_02; Quality: 6; human, Homo sapiens BS R00947; HS$ISG15_03; Quality: 6; human, Homo sapiens XX RN [1] RA Cook J. R., Emanuel S. L., Donnelly R. J., Soh J., RA Mariano T. M., Schwartz B., Rhee S., Pestka S. RT Sublocalization of the human interferon-gamma receptor RT accessory factor gene and characterization of accessory RT factor activity by yeast artificial chromosomal fragmentation RL J. Biol. Chem. 269:7013-7018 (1994). RN [2] RA Decker T., Lew D. J., Darnell J. E. RT Two distinct alpha-interferon-dependent signal transduction RT pathways may contribute to activation of transcription RT of the guanylate-binding protein gene RL Mol. Cell. Biol. 11:5147-5153 (1991). RN [3] RA Decker T., Lew D. J., Mirkowitch J., Darnell J. E. RT Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor RL EMBO J. 10:927-932 (1991). XX // AC T00301 XX ID T00301 XX DT 15.10.92 (created); ewi. DT 27.08.96 (updated); ewi. XX FA GAGA factor XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; . XX SZ 519 AA; 54.8 kDa (cDNA), 67 kDa (SDS) XX SQ MSLPMNSLYSLTWGDYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLL SQ DLLKNTPCKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQ SQ TVTKDDYTTHSIQLQHMIPQHHDQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATTQT SQ NAAGQQQTIVTTDAAKHDQAVIQAFLPARKRKPRVKKMSPTAPKISKVEGMDTIMGTPTS SQ SHGSGSVQQVLGENGAEGQLLSSTPIIKSEGQKVETILTMDPNNMIPVTSANAATGEITP SQ AQGATGSSGGNTSGVLSTPKAKRAKHPPGTEKPRSRSQSEQPATCPICYAVIRQSRNLRR SQ HLELRHFAKPGVKKEKKSKSGNDTTLDSSMEMNTTAEGDNTVGSDGAGGAGSAGGQSSGT SQ TPTRVISNAPQAAGAPAILAQGVLPQQQQQQQLQQQHQQHLTATLAGGGQAYIKHEGGGG SQ GGTGQQQQQQAAQQQGMQNVIHIVGDQVFIPQQQQPQPQ XX SC SwissProt #Q08605 XX FT 1 118 homologous to Broad complex and tramtrack FT 320 379 basic region FT 343 366 putative zinc finger (Cys2His2) FT 446 459 glutamine-rich region FT 485 498 glutamine-rich region XX SF pI 8.5 (calc.) XX CP ubiquitous in young embryos XX FF activator; FF disrupts nucleosomal structures leading to a rearrangement FF of nucleosomes through an energy-requiring process XX BS R01862; DROME$E74_01; Quality: 6; fruit fly, Drosophila melanogaster BS R01863; DROME$E74_02; Quality: 6; fruit fly, Drosophila melanogaster BS R01864; DROME$E74_03; Quality: 6; fruit fly, Drosophila melanogaster BS R01865; DROME$E74_04; Quality: 6; fruit fly, Drosophila melanogaster BS R01866; DROME$E74_05; Quality: 6; fruit fly, Drosophila melanogaster BS R01867; DROME$E74_06; Quality: 6; fruit fly, Drosophila melanogaster BS R02058; DROME$EVE_04; Quality: 6; fruit fly, Drosophila melanogaster BS R02059; DROME$EVE_05; Quality: 6; fruit fly, Drosophila melanogaster BS R02062; DROME$EVE_08; Quality: 6; fruit fly, Drosophila melanogaster BS R02063; DROME$EVE_09; Quality: 6; fruit fly, Drosophila melanogaster BS R02064; DROME$EVE_10; Quality: 6; fruit fly, Drosophila melanogaster BS R02065; DROME$EVE_11; Quality: 6; fruit fly, Drosophila melanogaster BS R02066; DROME$EVE_12; Quality: 6; fruit fly, Drosophila melanogaster BS R02067; DROME$EVE_13; Quality: 6; fruit fly, Drosophila melanogaster BS R02558; DROME$FTZ_32; Quality: 6; fruit fly, Drosophila melanogaster BS R02266; DROME$KR_01; Quality: 6; fruit fly, Drosophila melanogaster BS R02267; DROME$KR_02; Quality: 6; fruit fly, Drosophila melanogaster BS R02268; DROME$KR_03; Quality: 6; fruit fly, Drosophila melanogaster BS R02269; DROME$KR_04; Quality: 6; fruit fly, Drosophila melanogaster BS R02270; DROME$KR_05; Quality: 6; fruit fly, Drosophila melanogaster BS R02271; DROME$KR_06; Quality: 6; fruit fly, Drosophila melanogaster BS R01517; DROME$UBX_02; Quality: 6; fruit fly, Drosophila melanogaster BS R01520; DROME$UBX_05; Quality: 6; fruit fly, Drosophila melanogaster BS R01524; DROME$UBX_09; Quality: 6; fruit fly, Drosophila melanogaster BS R01526; DROME$UBX_11; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: L22205; DMGAGATRA(r). DR SwissProt: Q08605; GAGA_DROME. DR Flybase: FBgn0013263; Trl. XX RN [1] RA Soeller W. C., Oh C. E., Kornberg T. B. RT Isolation of cDNAs encoding the Drosophila GAGA transcription factor RL Mol. Cell. Biol. 13:7961-7970 (1993). RN [2] RA Tsukiyama T., Becker P. B., Wu C. RT ATP-dependent nucleosome disruption at a heat-shock RT promoter mediated by binding of GAGA transcription factor RL Nature 367:525-532 (1994). RN [3] RA Biggin M. D., Tjian R. RT Transcription factors that activate the Ultrabithorax RT promoter in developmentally staged extracts RL Cell 53:699-711 (1988). RN [4] RA Thummel C. S. RT The Drosophila E74 promoter contains essential sequences RT downstream from the start site of transcription RL Genes Dev. 3:782-792 (1989). RN [5] RA Kerrigan L. A., Croston G. E., Lira L. M., Kadonaga J. T. RT Sequence-specific transcriptional antirepression of RT the Drosophila Krueppel gene by the GAGA factor RL J. Biol. Chem. 266:574-582 (1991). XX // AC T00302 XX ID T00302 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GAL4 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0005; C6; 2.4.1.0.3. XX SZ 99 kDa XX SQ MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESR SQ LERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPL SQ TLRQHRISATSSSEESSNKGQRQLTVSIDSAAHHDNSTIPLDFMPRDALHGFDWSEEDDM SQ SDGLPFLKTDPNNNGFFGDGSLLCILRSIGFKPENYTNSNVNRLPTMITDRYTLASRSTT SQ SRLLQSYLNNFHPYCPIVHSPTLMMLYNNQIEIASKDQWQILFNCILAIGAWCIEGESTD SQ IDVFYYQNAKSHLTSKVFESGSIILVTALHLLSRYTQWRQKTNTSYNFHSFSIRMAISLG SQ LNRDLPSSFSDSSILEQRRRIWWSVYSWEIQLSLLYGRSIQLSQNTISFPSSVDDVQRTT SQ TGPTIYHGIIETARLLQVFTKIYELDKTVTAEKSPICAKKCLMICNEIEEVWRQAPKFLQ SQ MDISTTALTNLLKEHPWLSFTRFELKWKQLSLIIYVLRDFFTNFTQKKSQLEQDQNDHQS SQ YEVKRCSIMLSDAAQRTVMSVSSYMDNHNVTPYFAWNCSYYFFNAVLVPIKTLLSNSKSN SQ AENNETAQLLQQINTVLMLLKKLATFKIQTCEKYIQVLEEVCAPFLLSQCAIPLPHISYN SQ NSNGSAIKNIVGSATIAQYPTLPEENVNNISVKYVSPGSVGPSPVPLKSGASFSDLVKLL SQ SNRPPSRNSPVTIPRSTPSHRSVTPFLGQQQQLQSLVPLTPSALFGGANFNQSGNIADSS SQ LSFTLTNSSNGPNLITTQTNSQALSQPIASSNVHDNFMNNEITASKIDDGNNSKPLSPGW SQ TDQTAYNAFGITTGMFNTTTMDDVYNYLFDDEDTPPNPKKE XX SC SwissProt #P04386 XX FT 837 837 Ser-phosphorylation, requires intact FT DBD and activation domain XX FF activator, mediates galactose response; FF repressed by GAL80; FF binds to DNA and to nucleosome-assembled DNA XX IN T00303; GAL80; yeast, Saccharomyces cerevisiae. IN T01267; GAL80; yeast, Kluyveromyces lactis. XX MX M00049; F$GAL4_01 MX M00198; F$GAL4_C XX BS R00501; AS$GAL4_01; Quality: 1 BS R04203; AS$GAL4_02; Quality: 6 BS R01791; Y$CYC1_12; Quality: 2; yeast, Saccharomyces cerevisiae BS R00488; Y$GAL1_03; Quality: 1; yeast, Saccharomyces cerevisiae BS R00489; Y$GAL1_04; Quality: 1; yeast, Saccharomyces cerevisiae BS R00490; Y$GAL1_05; Quality: 1; yeast, Saccharomyces cerevisiae BS R00491; Y$GAL1_06; Quality: 1; yeast, Saccharomyces cerevisiae BS R00492; Y$GAL1_07; Quality: 1; yeast, Saccharomyces cerevisiae BS R00494; Y$GAL1_09; Quality: 1; yeast, Saccharomyces cerevisiae BS R00495; Y$GAL1_10; Quality: 1; yeast, Saccharomyces cerevisiae BS R00496; Y$GAL1_11; Quality: 1; yeast, Saccharomyces cerevisiae BS R00497; Y$GAL1_12; Quality: 1; yeast, Saccharomyces cerevisiae BS R00499; Y$GAL2_01; Quality: 6; yeast, Saccharomyces cerevisiae BS R00500; Y$GAL2_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R00502; Y$GAL7_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R00503; Y$GAL7_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R00504; Y$GAL80_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01020; Y$MEL1_01; Quality: 4; yeast, Saccharomyces cerevisiae XX DR EMBL: K01486; SCGAL4(g). DR SwissProt: P04386; GAL4_YEAST. DR PIR: A05022; RGBYG4. XX RN [1] RA Sadowski I., Niedbala D., Wood K., Ptashne M. RT GAL4 is phosporylated as a consequence of transcriptional activation RL Proc. Natl. Acad. Sci. USA 88:10510-10514 (1991). RN [2] RA Laughon A., Gesteland R. F. RT Primary structure of the Saccharomyces cerevisiae GAL4 gene RL Mol. Cell. Biol. 4:260-267 (1984). RN [3] RA Bram R. J., Lue N. F., Kornberg R. D. RT A GAL family of upstream activating sequences in yeast: RT roles in both induction and repression of transcription RL EMBO J. 5:603-608 (1986). RN [4] RA Selleck S. B., Majors J. RT Photofootprinting in vivo detects transcription-dependent RT changes in yeast TATA boxes RL Nature 325:173-177 (1987). RN [5] RA Giniger E., Varnum S. M., Ptashne M. RT Specific DNA binding of GAL4, a positive regulatory protein of yeast RL Cell 40:767-774 (1985). RN [6] RA Selleck S. B., Majors J. E. RT In Vivo DNA-Binding Properties of a Yeast Transcription Activator Protein RL Mol. Cell. Biol. 7:3260-3267 (1987). RN [7] RA Bram R. J., Kornberg R. D. RT Specific protein binding to far upstream activating RT sequences in polymerase II promoters RL Proc. Natl. Acad. Sci. USA 82:43-47 (1985). RN [8] RA Selleck S. B., Majors J. RT In vivo photofootprint changes at sequences between RT the yeast GAL1 upstream activating sequence and TATA RT element require activated GAL4 protein but no functional TATA element RL Proc. Natl. Acad. Sci. USA 85:5399-5403 (1988). RN [9] RA Chasman D. I., Kornberg R. D. RT GAL4 Protein: Purification, Association with GAL80 RT Protein, and Conserved Domain Structure RL Mol. Cell. Biol. 10:2916-2923 (1990). RN [10] RA Taylor I. C. A., Workman J. L., Schuetz T. J., Kingston R. E. RT Facilitated binding of GAL4 and heat shock factor RT to nucleosomal templates: differential function of DNA-binding domains RL Genes Dev. 5:1285-1298 (1991). RN [11] RA Pan T., Coleman J. E. RT Structure and function of the Zn(II) binding site RT within the DNA-binding domain of the GAL4 transcription factor RL Proc. Natl. Acad. Sci. USA 86:3145-3149 (1989). XX // AC T00303 XX ID T00303 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GAL80 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 435 AA XX SQ MDYNKRSSVSTVPNAAPIRVGFVGLNAAKGWAIKTHYPAILQLSSQFQITALYSPKIETS SQ IATIQRLKLSNATAFPTLESFASSSTIDMIVIAIQVASHYDVVMPLLEFSKNNPNLKYLF SQ VEWALACSLDQAESIYKAAAERGVQTIISLQGRKSPYILRAKELISQGYIGDINSIEIAG SQ NGGWYGYERPVKSPKYIYEIGNGVDLVTTTFGHTIDILQYMTSSYFSRINAMVFNNIPEQ SQ ELIDERGNRLGQRVPKTVPDHLLFQGTLLNGNVPVSCSFKGGKPTKKFTKNLVIDIHGTK SQ GDLKLEGDAGFAEISNLVLYYSGTRANDFPLANGQQAPLDPGYDAGKEIMEVYHLRNYNA SQ IVGNIHRLYQSISDFHFNTKKIPELPSQFVMQGFDFEGFPTLMDALILHRLIESVYKSNM SQ MGSTLNVSNISHYSL XX SC SwissProt #P04387 XX FF negative regulator of GAL4; FF probably functions by masking the GAL4 activation domain XX IN T00302; GAL4; yeast, Saccharomyces cerevisiae. IN T00458; LAC9; yeast, Kluyveromyces lactis. XX BS R04203; AS$GAL4_02; Quality: 6 BS R00489; Y$GAL1_04; Quality: 1; yeast, Saccharomyces cerevisiae BS R00493; Y$GAL1_08; Quality: 4; yeast, Saccharomyces cerevisiae BS R00498; Y$GAL1_13; Quality: 4; yeast, Saccharomyces cerevisiae BS R00503; Y$GAL7_02; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: Z21512; KLGAL80A(g). DR EMBL: X01667; SCGAL80(g). DR SwissProt: P04387; GAL8_YEAST. DR PIR: A03606; RGBYG8. XX RN [1] RA Zenke F. T., Zachariae W., Lunkes A., Breunig K. D. RT Gal80 proteins of Kluyveromyces lactis and Saccharaomyces RT cereviesiae are highly conserved but contribute differently RT to glucose repression of the galactose regulon RL Mol. Cell. Biol. 13:7566-7576 (1993). RN [2] RA Salmeron J. M., Langdon S. D., Johnston S. A. RT Interaction between Transcriptional Activator Protein RT LAC9 and Negative Regulatory Protein GAL80 RL Mol. Cell. Biol. 9:2950-2956 (1989). RN [3] RA Lohr D., Torchia T., Hopper J. RT The Regulatory Protein GAL80 Is a Determinant of the RT Chromatin Structure of the Yeast GAL1-10 Control Region RL J. Biol. Chem. 262:15589-15597 (1987). RN [4] RA Chasman D. I., Kornberg R. D. RT GAL4 Protein: Purification, Association with GAL80 RT Protein, and Conserved Domain Structure RL Mol. Cell. Biol. 10:2916-2923 (1990). XX // AC T00304 XX ID T00304 XX DT 28.01.93 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA GATA-1 XX OS clawed frog, Xenopus laevis OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CL C0003; CC (g); 2.2.1.1.1.1. XX SF 2 zinc finger motifs XX MX M00126; V$GATA1_02 MX M00127; V$GATA1_03 MX M00128; V$GATA1_04 MX M00203; V$GATA_C XX BS R02156; GATA1$CONS; Quality: 6 XX DR EMBL: M76566; XLGATAA(r). DR EMBL: M76563; XLGATAB(r). DR SwissProt: P23767; GATA_XENLA. DR SwissProt: P23768; GATB_XENLA. DR PIR: A41602; A41602. DR PIR: B41602; B41602. XX RN [1] RA Zon L. I., Mather C., Burgess S., Bolce M. E., Harland R. M., Orkin S. H. RT Expression of GATA-binding proteins during embryonic RT development in Xenopus laevis RL Proc. Natl. Acad. Sci. USA 88:10642-10646 (1991). XX // AC T00305 XX ID T00305 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GATA-1 XX SY EF1; EFgammaa; Eryf-1; GF-1; NF-E1 (1); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0003; CC (g); 2.2.1.1.1.1. XX SZ 413 AA; 42.6 kDa (cDNA), 50 kDa (SDS) XX SQ MDFPGLGALGTSEPLPQFVDSALVSSPSDSTGFFSSGPEGLDAASSSTSPNAATAAASAL SQ AYYREAEAYRHSPVFQVYPLLNSMEGIPGGSPYASWAYGKTALYPASTVCPSHEDAPSQA SQ LEDQEGKSNNTFLDTLKTERLSPDLLTLGTALPASLPVTGSAYGGADFPSPFFSPTGSPL SQ SSAAYSSPKFHGSLPLAPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRP SQ LIRPKKRMIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYFKLHQVNRPLTMRKD SQ GIQTRNRKASGKGKKKRGSNLAGAGAAEGPAGGFMVVAGSSSSGNCGEVASGLALGTAGT SQ AHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTTSFPTGPAPTTSSTSVIAPLSS XX SC SwissProt #P17679 XX SF 2 zinc finger motifs XX CP erythroid XX FF required for erythroid differentiation; FF absence cannot be compensated by other GATA-proteins XX MX M00075; V$GATA1_01 MX M00126; V$GATA1_02 MX M00127; V$GATA1_03 MX M00128; V$GATA1_04 MX M00203; V$GATA_C XX BS R00534; CHICK$BAG_08; Quality: 1; chick, Gallus gallus BS R02156; GATA1$CONS; Quality: 2 BS R02882; HS$AG_02; Quality: 4; human, Homo sapiens BS R02883; HS$AG_03; Quality: 4; human, Homo sapiens BS R02886; HS$AG_06; Quality: 4; human, Homo sapiens BS R03438; HS$AG_09; Quality: 5; human, Homo sapiens BS R03442; HS$AG_13; Quality: 5; human, Homo sapiens BS R03443; HS$AG_14; Quality: 5; human, Homo sapiens BS R00522; HS$BG_03; Quality: 4; human, Homo sapiens BS R00523; HS$BG_04; Quality: 4; human, Homo sapiens BS R00524; HS$BG_05; Quality: 4; human, Homo sapiens BS R00525; HS$BG_06; Quality: 4; human, Homo sapiens BS R04289; HS$BG_16; Quality: 5; human, Homo sapiens BS R04292; HS$BG_19; Quality: 5; human, Homo sapiens BS R04294; HS$BG_21; Quality: 5; human, Homo sapiens BS R04296; HS$BG_23; Quality: 5; human, Homo sapiens BS R02889; HS$DG_01; Quality: 1; human, Homo sapiens BS R03487; HS$DG_02; Quality: 4; human, Homo sapiens BS R03116; HS$EG_04; Quality: 1; human, Homo sapiens BS R00550; HS$GG_04; Quality: 1; human, Homo sapiens BS R01858; HS$GG_19; Quality: 1; human, Homo sapiens BS R01247; HS$PBGD_01; Quality: 4; human, Homo sapiens BS R01253; HS$PBGD_07; Quality: 1; human, Homo sapiens BS R01254; HS$PBGD_08; Quality: 4; human, Homo sapiens BS R00569; HS$ZG_05; Quality: 4; human, Homo sapiens BS R00507; MOUSE$AAG_01; Quality: 2; mouse, Mus musculus BS R00512; MOUSE$AAG_06; Quality: 2; mouse, Mus musculus BS R00540; MOUSE$BMG_01; Quality: 2; mouse, Mus musculus BS R00541; MOUSE$BMG_02; Quality: 1; mouse, Mus musculus BS R00543; MOUSE$BMG_04; Quality: 2; mouse, Mus musculus BS R02890; MOUSE$EPOR_01; Quality: 5; mouse, Mus musculus BS R03347; MOUSE$EPOR_03; Quality: 1; mouse, Mus musculus BS R03213; MOUSE$GATA1_01; Quality: 1; mouse, Mus musculus BS R03884; MOUSE$MCCPA_01; Quality: 3; mouse, Mus musculus BS R03206; MOUSE$PBGD_06; Quality: 1; mouse, Mus musculus BS R03207; MOUSE$PBGD_07; Quality: 1; mouse, Mus musculus BS R03736; MOUSE$PBGD_08; Quality: 1; mouse, Mus musculus BS R03737; MOUSE$PBGD_09; Quality: 1; mouse, Mus musculus XX DR EMBL: X15763; MMGF1(r). DR SwissProt: P17679; GAT1_MOUSE. DR PIR: S04655; S04655. XX RN [1] RA Mignotte V., Wall L., deBoer E., Grosveld F., Romeo P.-H. RT Two tissue-specific factors bind to the erythroid RT promoter of the human porphobilinogen deaminase gene RL Nucleic Acids Res. 17:37-54 (1989). RN [2] RA Frampton J., Walker M., Plumb M., Harrison P. R. RT Synergy between the NF-E1 erythroid-specific transcription RT factor and the CACCC factor in the erythroid-specific RT promoter of the human porphobilinogen deaminase gene RL Mol. Cell. Biol. 10:3838-3842 (1990). RN [3] RA Barnhart K. M., Kim C. G., Sheffery M. RT Purification and characterization of an erythroid RT cell-specific factor that binds the murine alpha- and beta-globin genes RL Mol. Cell. Biol. 9:2606-2614 (1989). RN [4] RA Wall L., deBoer E., Grosveld F. RT The human beta-globin gene 3' enhancer contains multiple RT binding sites for an erythroid-specific protein RL Genes Dev. 2:1089-1100 (1989). RN [5] RA Tsai S.-F., Martin D. I. K., Zon L. I., D'Andrea A. RA D., Wong G. G., Orkin S. H. RT Cloning of cDNA for the major DNA-binding protein RT of the erythroid lineage through expression in mammalian cells RL Nature 339:446-451 (1989). RN [6] RA Porcher C., Pitiot G., Plumb M., Lowe S., de Verneuil H., Grandchamp B. RT Characterization of hypersensitive sites, protein-binding RT motifs, and regulatory elements in both promoters RT of the mouse porphobilinogen deaminase gene RL J. Biol. Chem. 266:10562-10569 (1991). RN [7] RA Orkin S. H. RT Globin gene regulation and switching: Circa 1990 RL Cell 63:665-672 (1990). RN [8] RA Pevny L., Simon M. C., Robertson E., Klein W. H., RA Tsai S.-F., D'Agati V., Orkin S. H., Constantini F. RT Erythroid differentiation in chimaeric mice blocked RT by a targeted mutation in the gene for transcription factor GATA-1 RL Nature 349:257-260 (1991). RN [9] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D. RT Activity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). RN [10] RA Evans T., Felsenfeld G. RT trans-activation of a globin promoter in nonerythroid cells RL Mol. Cell. Biol. 11:843-853 (1991). RN [11] RA Hannon R., Evans T., Felsenfeld G., Gould H. RT Structure and promoter activity of the gene for the RT erythroid transcription factor GATA-1 RL Proc. Natl. Acad. Sci. USA 86:3004-3008 (1991). RN [12] RA Fucharoen S., Shimizu K., Fukumaki Y. RT A novel C-T transition within the distal CCAAT motif RT of the Ggamma-globin gene in the Japanese HPFH: implication RT of factor binding in elevated fetal globin expression RL Nucleic Acids Res. 18:5245 (1990). XX // AC T00306 XX ID T00306 XX DT 21.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GATA-1 XX SY EF1 (chick); EFgammaa; Eryf1 (chick); GF-1; NF-E1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0003; CC (g); 2.2.1.1.1.1. XX SZ 413 AA; 42.8 kDa (cDNA), 51 kDa (SDS) XX SQ MEFPGLGSLGTSEPLPQFVDPALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAAL SQ AYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTREDSPPQA SQ VEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPL SQ NSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRP SQ LIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKD SQ GIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGPPGT SQ AHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS XX SC SwissProt #P15976 XX SF 2 zinc finger motifs XX CP erythroid cells, megakaryocytes, mast cells XX FF activator; FF negative regulator of gamma-globin in adults; FF down-regulated by TPA [11]; XX MX M00126; V$GATA1_02 MX M00127; V$GATA1_03 MX M00128; V$GATA1_04 MX M00203; V$GATA_C XX BS R02156; GATA1$CONS; Quality: 2 BS R02882; HS$AG_02; Quality: 4; human, Homo sapiens BS R02883; HS$AG_03; Quality: 4; human, Homo sapiens BS R02884; HS$AG_04; Quality: 4; human, Homo sapiens BS R02885; HS$AG_05; Quality: 4; human, Homo sapiens BS R02886; HS$AG_06; Quality: 4; human, Homo sapiens BS R03437; HS$AG_08; Quality: 4; human, Homo sapiens BS R03438; HS$AG_09; Quality: 4; human, Homo sapiens BS R03442; HS$AG_13; Quality: 4; human, Homo sapiens BS R03443; HS$AG_14; Quality: 4; human, Homo sapiens BS R03491; HS$BG_12; Quality: 4; human, Homo sapiens BS R03115; HS$EG_03; Quality: 1; human, Homo sapiens BS R03116; HS$EG_04; Quality: 1; human, Homo sapiens BS R00548; HS$GG_02; Quality: 4; human, Homo sapiens BS R00549; HS$GG_03; Quality: 1; human, Homo sapiens BS R00550; HS$GG_04; Quality: 1; human, Homo sapiens BS R00551; HS$GG_05; Quality: 2; human, Homo sapiens BS R02826; HS$GG_26; Quality: 4; human, Homo sapiens BS R02829; HS$GG_29; Quality: 4; human, Homo sapiens BS R02831; HS$GG_31; Quality: 4; human, Homo sapiens BS R03261; HS$GG_34; Quality: 4; human, Homo sapiens BS R04196; HS$GG_37; Quality: 5; human, Homo sapiens BS R04197; HS$GG_38; Quality: 5; human, Homo sapiens BS R04200; HS$GG_41; Quality: 4; human, Homo sapiens BS R04201; HS$GG_42; Quality: 5; human, Homo sapiens BS R00597; HS$GP2B_02; Quality: 4; human, Homo sapiens BS R01710; HS$GP2B_05; Quality: 1; human, Homo sapiens BS R03268; HS$GPB_01; Quality: 1; human, Homo sapiens BS R02442; HS$GPC_02; Quality: 1; human, Homo sapiens BS R02443; HS$GPC_03; Quality: 1; human, Homo sapiens BS R02447; HS$GPC_07; Quality: 1; human, Homo sapiens BS R01247; HS$PBGD_01; Quality: 4; human, Homo sapiens BS R01253; HS$PBGD_07; Quality: 1; human, Homo sapiens BS R01254; HS$PBGD_08; Quality: 4; human, Homo sapiens BS R01432; HS$TRDL_04; Quality: 5; human, Homo sapiens BS R00566; HS$ZG_02; Quality: 4; human, Homo sapiens BS R00569; HS$ZG_05; Quality: 4; human, Homo sapiens BS R01218; RAT$PF4_01; Quality: 1; rat, Rattus norvegicus XX DR EMBL: X17254; HSERYF1(r). DR EMBL: M30601; HSGF1A(r). DR SwissProt: P15976; GAT1_HUMAN. DR PIR: A34888; A34888. DR PIR: S07121; S07121. XX RN [1] RA Jarman A. P., Wood W. G., Sharpe J. A., Gourdon G., Ayyub H., Higgs D. R. RT Characterization of the major regulatory element upstream RT of the human alpha-globin gene cluster RL Mol. Cell. Biol. 11:4679-4689 (1991). RN [2] RA Martin D. I. K., Zon L. I., Mutter G., Orkin S. H. RT Expression of an erythroid transcription factor in RT megakaryocytic and mast cell lineages RL Nature 344:444f (1990). RN [3] RA Romeo P.-H., Prandini M.-H., Joulin V., Mignotte V., RA Prenant M., Vainchenker W., Marguerie G., Uzan G. RT Megakaryocytic and erythrocytic lineages share specific RT transcription factors RL Nature 344:447f (1990). RN [4] RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S. RT The deletion of the distal CCAAT box region of the RT Agamma-globin gene in black HPFH abolishes the binding RT of the erythroid specific protein NFE3 and of the CCAAT displacement protein RL Nucleic Acids Res. 17:6681-6691 (1989). RN [5] RA Barnhart K. M., Kim C. G., Sheffery M. RT Purification and characterization of an erythroid RT cell-specific factor that binds the murine alpha- and beta-globin genes RL Mol. Cell. Biol. 9:2606-2614 (1989). RN [6] RA Trainor C. D., Evans T., Felsenfeld G., Boguski M. S. RT Structure and evolution of a human erythroid transcription factor RL Nature 343:92-96 (1990). RN [7] RA Martin D. I. K., Tsai S.-F., Orkin S. H. RT Increased gamma-globin expression in a nondeletion RT HPFH mediated by an erythroid-specific DNA-binding factor RL Nature 338:435-438 (1989). RN [8] RA Gumucio D. L., Rood K. L., Gray T. A., Riordan M. RA F., Sartor C. I., Collins F. S. RT Nuclear Proteins That Bind the Human gamma-Globin RT Gene Promoter: Alterations in Binding Produced by RT Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin RL Mol. Cell. Biol. 8:5310-5322 (1988). RN [9] RA Broggini M., Ponti M., Ottolenghi S., D'Incalci M., RA Mongelli N., Mantovani R. RT Distamycins inhibit the binding of OTF-1 and NFE-1 RT transfactors to their conserved DNA elements RL Nucleic Acids Res. 17:1051-1059 (1989). RN [10] RA Purucker M., Bodine D., Lin H., McDonagh K., Nienhuis A. W. RT Structure and function of the enhancer 3' to the human Agamma globin gene RL Nucleic Acids Res. 18:7407 (1990). RN [11] RA Mignotte V., Navarro S., Eleouet F.-F., Zon L. I., Romeo P.-H. RT The extinction of erythroid genes after tetradecanoylphorbol RT acetate treatment of erythroleukemic cells correlates RT with down-regulation of the tissue-specific factors NF-E1 and NF-E2 RL J. Biol. Chem. 265:22090-22092 (1990). RN [12] RA Berry M., Grosveld F., Dillon N. RT A single point mutation is the cause of the Greek RT form of hereditary persistance of fetal hemoglobin RL Nature 358:499-502 (1992). RN [13] RA Lee M.-H., Temizer D. H., Clifford J. A., Quertermous T. RT Cloning of the GATA-binding protein that regulates RT endothelin-1 gene expression in endothelial cells RL J. Biol. Chem. 266:16188-16192 (1991). RN [14] RA Zon L. I., Tsai S.-F., Burgess S., Matsudaira P., RA Bruns G. A. P., Orkin S. H. RT The major human erythroid DNA-binding protein (GF-1): RT primary sequence and localization of the gene to the X chromosome RL Proc. Natl. Acad. Sci. USA 87:668-672 (1990). RN [15] RA Hannon R., Evans T., Felsenfeld G., Gould H. RT Structure and promoter activity of the gene for the RT erythroid transcription factor GATA-1 RL Proc. Natl. Acad. Sci. USA 88:3004-3008 (1991). RN [16] RA Gong Q.-H., Stern J., Dean A. RT Transcriptional role of a conserved GATA-1 site in RT the human epsilon-globin gene promoter RL Mol. Cell. Biol. 11:2558-2566 (1991). RN [17] RA McDonagh K. T., Lin H. J., Lowrey C. H., Bodine D. M., Nienhuis A. W. RT The upstream region of the human gamma-globin gene promoter RL J. Biol. Chem. 266:11965-11974 (1991). RN [18] RA Yu C.-Y., Motamed K., Chen J., Bailey A. D., Shen C.-K. J. RT The CACC box upstream of human embryonic epsilon globin RT gene binds Sp1 and is a functional promoter element in vitro and in vivo RL J. Biol. Chem. 266:8907-8915 (1991). RN [19] RA Orkin S. H. RT Globin gene regulation and switching: Circa 1990 RL Cell 63:665-672 (1990). RN [20] RA Pevny L., Simon M. C., Robertson E., Klein W. H., RA Tsai S.-F., D'Agati V., Orkin S. H., Constantini F. RT Erythroid differentiation in chimaeric mice blocked RT by a targeted mutation in the gene for transcription factor GATA-1 RL Nature 349:257-260 (1991). RN [21] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D. RT Activity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). RN [22] RA Evans T., Felsenfeld G. RT trans-activation of a globin promoter in nonerythroid cells RL Mol. Cell. Biol. 11:843-853 (1991). RN [23] RA Hannon R., Evans T., Felsenfeld G., Gould H. RT Structure and promoter activity of the gene for the RT erythroid transcription factor GATA-1 RL Proc. Natl. Acad. Sci. USA 86:3004-3008 (1991). RN [24] RA Joulin V., Bouries D., Eleouet J.-F., Labastie M.-C., RA Chretien S., Mattei M.-G., Romeo P.-H. RT A t-cell specific TCR delta DNA binding protein is RT a member of the human GATA family RL EMBO J. 10:1809-1816 (1991). RN [25] RA Fucharoen S., Shimizu K., Fukumaki Y. RT A novel C-T transition within the distal CCAAT motif RT of the Ggamma-globin gene in the Japanese HPFH: implication RT of factor binding in elevated fetal globin expression RL Nucleic Acids Res. 18:5245 (1990). XX // AC T00307 XX ID T00307 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA GATA-2 XX SY NF-E1b; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0003; CC (g); 2.2.1.1.2. XX SZ 56 kDa (SDS) XX SQ MEVATDQPRWMTHHAVLNGQHPESHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYY SQ ANSAHARARVSYSQAHARLTGSQMCRPHLIHSPGIPWLDSSKAALSAHHHNPWTVNPFTK SQ TPLHPSAAGAPGAISVYPGSSTSSTASVSSLTPASHSGSHLFGFPPTPPKEVSPDPNSTS SQ AASPSSSAGARQEDKDSIKYQVSLSEGMKMESASPLRSSLTSMGAQPSTHHPIPTYPSYV SQ PAAHDYSSSLFHPGSFLGGPASSFTPKPRSKARSCSEGRECVNCGATATPLWRRDGTGHY SQ LCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACG SQ LYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGSECFEELSKCMQEKSSPFSAAALA SQ SHMAPMGHLPPFSHSGHILPTPTPIHPSSSISFGHPHPSSMVTAMG XX SC SwissProt #P23824 XX CP erythroid cells XX MX M00203; V$GATA_C XX BS R02157; GATA2$CONS; Quality: 2 XX DR EMBL: X56930; GDNFE1B(r). DR SwissProt: P23824; GAT2_CHICK. DR PIR: A36389; A36389. XX RN [1] RA Orkin S. H. RT Globin gene regulation and switching: Circa 1990 RL Cell 63:665-672 (1990). RN [2] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D. RT Activity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). XX // AC T00308 XX ID T00308 XX DT 28.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GATA-2 XX SY NF-E1b (chick); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0003; CC (g); 2.2.1.1.2. XX SZ 480 AA XX SQ MEVAPEQPGWMAHPAVLNAHDPDSHHPGLAHNYMEPAHVLPPDEVDVFFNHLDSQGNPYY SQ ANPAHARAAVSYSPAHARLTGSQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP SQ FSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKE SQ VSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQP SQ ATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGA SQ TATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLW SQ RRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKC SQ MQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG XX SC SwissProt #P23769 XX SF 2 zinc finger motifs XX CP widespread expression XX MX M00076; V$GATA2_01 MX M00203; V$GATA_C XX BS R02157; GATA2$CONS; Quality: 6 XX DR EMBL: M68891; HSGATA(r). DR SwissProt: P23769; GAT2_HUMAN. DR PIR: A40815; A40815. DR Compel: C00026 DR Compel: C00088 XX RN [1] RA Lee M.-H., Temizer D. H., Clifford J. A., Quertermous T. RT Cloning of the GATA-binding protein that regulates RT endothelin-1 gene expression in endothelial cells RL J. Biol. Chem. 266:16188-16192 (1991). XX // AC T00309 XX ID T00309 XX DT 28.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GATA-2 XX OS clawed frog, Xenopus laevis OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CL C0003; CC (g); 2.2.1.1.2. XX SZ 452 AA XX SQ MEVATDQPRWMAHHAVLNGQHPDSHHPGLAHNYMEPTQLLPPDEVDVFFNHLDSQGNPYY SQ ANSAHARARVSYSQAHARLTGSQMCRPHLLHSPGLPWLESGKTALSAAHHHNPWTVSPFG SQ KAPLHPAARGGSLYPGTGSSACPSSSHSSPHLFGFPPTPPKDVSPDPGPASPPSSSRLED SQ KDSIKYQMSLSEGMKMEGGSPLRSSLAPMGTQCSTHHPIPTYPSYVPAAHDYSSGLFHPG SQ SLLGGPASSFTPKQRSKSRSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQ SQ NRPLIKPKRRLSAARRAGTCCANCQTSTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTM SQ KKEGIQTRNRKMSNKSKKNKKGSECFEELSRCMQEKSSPFSAAALASHMAPMGHLAPFSH SQ SGHILQTPTPIHPSSSLSFGHPHHSSMVTAMG XX SC SwissProt #P23770 XX SF 2 zinc finger motifs XX MX M00203; V$GATA_C XX BS R02157; GATA2$CONS; Quality: 6 XX DR EMBL: M76564; XLGATAC(r). DR SwissProt: P23770; GAT2_XENLA. DR PIR: C41602; C41602. XX RN [1] RA Zon L. I., Mather C., Burgess S., Bolce M. E., Harland R. M., Orkin S. H. RT Expression of GATA-binding proteins during embryonic RT development in Xenopus laevis RL Proc. Natl. Acad. Sci. USA 88:10642-10646 (1991). XX // AC T00310 XX ID T00310 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA GATA-3 XX SY NF-E1c (chick); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0003; CC (g); 2.2.1.1.3. XX SZ 443 AA; 48 kDa (cDNA) XX SQ MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMEAQYPLTEEVDVLFNIDGQGNHVP SQ SYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALSSHHTASPWNLSPFSKTS SQ IHHGSPGPLSVYPPASSSSLAAGHSSPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEK SQ ECLKYQVQLPDSMKLETSHSRGSMTTLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLG SQ GSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPL SQ IKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEG SQ IQTRNRKMSSKSKKCKKVHDALEDFPKSSSFNPAALSRHMSSLSHISPFSHSSHMLTTPT SQ PMHPPSGLSFGPHHPSSMVTAMG XX SC SwissProt #P23772 XX SF 2 zinc finger motifs SF pI 9.89 XX CP T cells, placenta, fetal brain CN B lymphocytes XX MX M00203; V$GATA_C XX BS R02158; GATA3$CONS; Quality: 6 XX DR EMBL: X55123; MMGATA3M(r). DR SwissProt: P23772; GAT3_MOUSE. DR PIR: B39794; B39794. XX RN [1] RA Ko L. J., Yamamoto M., Leonard M. W., George K. M., Ting P., Engel J. D. RT Murine and human T-lymphocyte GATA-3 factors mediate RT transcription through a cis-regulatory element within RT the human T-cell receptor Delta gene enhancer RL Mol. Cell. Biol. 11:2778-2784 (1991). RN [2] RA Orkin S. H. RT Globin gene regulation and switching: Circa 1990 RL Cell 63:665-672 (1990). RN [3] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D. RT Activity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). RN [4] RA Ho I.-C., Vorhees P., Marin N., Oakley B. K., Tsai RA S.-F., Orkin S. H., Leiden J. M. RT Human GATA-3: a lineage-restricted transcription factor RT that regulates the expression of the T cell receptor alpha gene RL EMBO J. 10:1187-1192 (1991). RN [5] RA Ko L. J., Yamamoto M., Leonard M. W., George K. M., Ting P., Engel J. D. RT Murine and human T-lymphocyte GATA-3 factors mediate RT transcription through a cis-regulatory element within RT the human T-cell receptor delta gene enhancer RL Mol. Cell. Biol. 11:2778-2784 (1991). RN [6] RA Joulin V., Bouries D., Eleouet J.-F., Labastie M.-C., RA Chretien S., Mattei M.-G., Romeo P.-H. RT A t-cell specific TCR delta DNA binding protein is RT a member of the human GATA family RL EMBO J. 10:1809-1816 (1991). XX // AC T00311 XX ID T00311 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA GATA-3 XX SY NF-E1c (chick); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0003; CC (g); 2.2.1.1.3. XX SZ 443 AA; 47-49 kDa (SDS), 48 kDa (cDNA) XX SQ MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV SQ PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT SQ SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE SQ KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL SQ GGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPL SQ IKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEG SQ IQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTPT SQ PMHPPSSLSFGPHHPSSMVTAMG XX SC SwissProt #P23771 XX SF 2 zinc finger motifs XX CP T lymphocytes, neuroblastoma cell lines CN B lymphocytes XX MX M00077; V$GATA3_01 MX M00203; V$GATA_C XX BS R02158; GATA3$CONS; Quality: 1 BS R03268; HS$GPB_01; Quality: 1; human, Homo sapiens BS R02795; HS$TCRA_03; Quality: 1; human, Homo sapiens BS R03723; HS$TCRBL_10; Quality: 4; human, Homo sapiens BS R01432; HS$TRDL_04; Quality: 4; human, Homo sapiens BS R00507; MOUSE$AAG_01; Quality: 4; mouse, Mus musculus XX DR EMBL: X55037; HSGATA3(r). DR EMBL: M69106; HSGATA3BP(r). DR EMBL: X55122; HSGATA3M(r). DR EMBL: X58072; HSGATA3R(r). DR SwissProt: P23771; GAT3_HUMAN. DR PIR: A39794; A39794. DR PIR: A41148; A41148. DR PIR: S15027; S15027. DR PIR: S16326; S16326. DR Compel: C00026 DR Compel: C00088 XX RN [1] RA Marine J., Winoto A. RT The human enhancer-binding protein Gata3 binds to RT several T-cell receptor regulatory elemets RL Proc. Natl. Acad. Sci. USA 88:7284-7288 (1991). RN [2] RA Ko L. J., Yamamoto M., Leonard M. W., George K. M., Ting P., Engel J. D. RT Murine and human T-lymphocyte GATA-3 factors mediate RT transcription through a cis-regulatory element within RT the human T-cell receptor Delta gene enhancer RL Mol. Cell. Biol. 11:2778-2784 (1991). RN [3] RA Orkin S. H. RT Globin gene regulation and switching: Circa 1990 RL Cell 63:665-672 (1990). RN [4] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D. RT Activity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). RN [5] RA Ho I.-C., Vorhees P., Marin N., Oakley B. K., Tsai RA S.-F., Orkin S. H., Leiden J. M. RT Human GATA-3: a lineage-restricted transcription factor RT that regulates the expression of the T cell receptor alpha gene RL EMBO J. 10:1187-1192 (1991). RN [6] RA Ko L. J., Yamamoto M., Leonard M. W., George K. M., Ting P., Engel J. D. RT Murine and human T-lymphocyte GATA-3 factors mediate RT transcription through a cis-regulatory element within RT the human T-cell receptor delta gene enhancer RL Mol. Cell. Biol. 11:2778-2784 (1991). RN [7] RA Joulin V., Bouries D., Eleouet J.-F., Labastie M.-C., RA Chretien S., Mattei M.-G., Romeo P.-H. RT A t-cell specific TCR delta DNA binding protein is RT a member of the human GATA family RL EMBO J. 10:1809-1816 (1991). XX // AC T00312 XX ID T00312 XX DT 28.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GATA-3 XX OS clawed frog, Xenopus laevis OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CL C0003; CC (g); 2.2.1.1.3. XX SZ 435 AA XX SQ MEVSAEQPRWVSHPHHPALLNGQHTDSHHQVHNYMDPSQYPPPEDMDVLFNIDAQGNHVP SQ SYYSNSVRTVPRYPPPHHGSLVCHPSILQSWTDGRKSLGGPHAASAWNLPFTKPSIHHNS SQ PGGLSVYPPASSASLATGHSSPHLFTFPPTPPKDVSPDPSISTSGSTSSSRHEEKECVVS SQ KYQVSLGDTGMKLESLHPRNSMSGIGGVSAHHPITTYPDYYGAGLFQPGSILDGSPTHFS SQ SNARPKTRSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRL SQ SAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRK SQ MSSKSKKSKKFHDSLEDYPKSSSFSPAALSRHMSSLSHIPFSHSSHMLTTPTPMHPPSSL SQ SFGPHHPSSMVTAMG XX SC SwissProt #P23773 XX SF 2 zinc finger motifs XX MX M00203; V$GATA_C XX BS R02158; GATA3$CONS; Quality: 6 XX DR EMBL: M76565; XLGATAD(r). DR SwissProt: P23773; GAT3_XENLA. DR PIR: D41602; D41602. XX RN [1] RA Zon L. I., Mather C., Burgess S., Bolce M. E., Harland R. M., Orkin S. H. RT Expression of GATA-binding proteins during embryonic RT development in Xenopus laevis RL Proc. Natl. Acad. Sci. USA 88:10642-10646 (1991). XX // AC T00313 XX ID T00313 XX DT 26.01.93 (created); hse. DT 10.01.96 (updated); hiwi. XX FA GATA-3 XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX CL C0003; CC (g); . XX SF 2 zinc finger motifs XX CP T cells, brain, erythrocytes XX MX M00203; V$GATA_C XX BS R02158; GATA3$CONS; Quality: 6 XX RN [1] RA Orkin S. H. RT Globin gene regulation and switching: Circa 1990 RL Cell 63:665-672 (1990). RN [2] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D. RT Activity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). RN [3] RA Ho I.-C., Vorhees P., Marin N., Oakley B. K., Tsai RA S.-F., Orkin S. H., Leiden J. M. RT Human GATA-3: a lineage-restricted transcription factor RT that regulates the expression of the T cell receptor alpha gene RL EMBO J. 10:1187-1192 (1991). RN [4] RA Ko L. J., Yamamoto M., Leonard M. W., George K. M., Ting P., Engel J. D. RT Murine and human T-lymphocyte GATA-3 factors mediate RT transcription through a cis-regulatory element within RT the human T-cell receptor delta gene enhancer RL Mol. Cell. Biol. 11:2778-2784 (1991). RN [5] RA Joulin V., Bouries D., Eleouet J.-F., Labastie M.-C., RA Chretien S., Mattei M.-G., Romeo P.-H. RT A t-cell specific TCR delta DNA binding protein is RT a member of the human GATA family RL EMBO J. 10:1809-1816 (1991). XX // AC T00314 XX ID T00314 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA GATA-3 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0003; CC (g); 2.2.1.1.3. XX SZ 55 kDa (SDS) XX SQ MEVSTDQPRWVSHHHPAVLNGQHPDSHHPTLGHTYMDPTQYPLAEEVDVLFNIDGQGNPV SQ PPYYGNSVRATVQRYPTAHHGSQVCRPPLLHGSLPWLDGSKALSSHHSASPWNLSPFSKT SQ SIHHSSPGPLSVYPPASSSTLSAGHSSPHLFTFPPTPPKDVSPDPSISTPGSTGSTRQDE SQ KECIKYQVSLADTMKLESSHSRSSMASLGGATSSAHHPITTYPPYVPEYSSGLFPPSSLL SQ GGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRP SQ LIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKE SQ GIQTRNRKMSSKSKKCKKVHDNLEDFPKSSSFNPAALSRHMSSISHISPFSHSSHMLTTP SQ TPMHPPSSLSFGPHHPSSMVTAMG XX SC SwissProt #P23825 XX SF 2 zinc finger motifs XX CP T cells, brain, erythrocytes XX FF may play a regulatory role in developing chicken brain FF and T-cell specific gene expression XX MX M00203; V$GATA_C XX BS R02158; GATA3$CONS; Quality: 2 XX DR EMBL: X56931; GDNFE1C(r). DR SwissProt: P23825; GAT3_CHICK. DR PIR: B36389; B36389. XX RN [1] RA Orkin S. H. RT Globin gene regulation and switching: Circa 1990 RL Cell 63:665-672 (1990). RN [2] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D. RT Activity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). RN [3] RA Ho I.-C., Vorhees P., Marin N., Oakley B. K., Tsai RA S.-F., Orkin S. H., Leiden J. M. RT Human GATA-3: a lineage-restricted transcription factor RT that regulates the expression of the T cell receptor alpha gene RL EMBO J. 10:1187-1192 (1991). RN [4] RA Ko L. J., Yamamoto M., Leonard M. W., George K. M., Ting P., Engel J. D. RT Murine and human T-lymphocyte GATA-3 factors mediate RT transcription through a cis-regulatory element within RT the human T-cell receptor delta gene enhancer RL Mol. Cell. Biol. 11:2778-2784 (1991). RN [5] RA Joulin V., Bouries D., Eleouet J.-F., Labastie M.-C., RA Chretien S., Mattei M.-G., Romeo P.-H. RT A t-cell specific TCR delta DNA binding protein is RT a member of the human GATA family RL EMBO J. 10:1809-1816 (1991). XX // AC T00315 XX ID T00315 XX DT 15.10.92 (created); ewi. DT 05.12.96 (updated); ewi. XX FA GBF XX SY G-box binding factor; XX OS slime mould, Dictyostelium discoideum OC eukaryota; animalia; protozoa; sarcomastigophora; OC sarcodina; rhizopoda; eumycetozoa; dictyostelia; dictyosteliida; OC dictyosteliidae XX CL C0004; CC; . XX SZ 708 AA; 79.3 kDa, 92 kDa (SDS) XX SQ MLSTHHHQGNSSSSSSSSSPSQTIGGSDLSNISALPLPLPSIFTTAQNQMNPPILFPPTS SQ SLLGGSSNTPSFLLPPSSIMSSNVFPSHDGQYPDMPNMVDQYQIHPNQNPHYNYQYQLMF SQ MQQQAQQNQPPQQNQQQQHHQQQQQQPQHHQQMQQQQHHQQMQQQQQHHQQMQQQQHHQQ SQ MQHHQLQQHQHQHQQQQQQQQHQQQHHQQQQQQQQQHHQQQQHHQHSQPQQQHQHNQQQQ SQ HQHNQQQHQQQQNQIQMVPQQPQSLSNSGNNNNNNNNNNNSNNNNNNNNNNNSHQLNNLT SQ LSQNNTSGSNTPSPSTKGKRKHHETSNSEKKDSSGQTIPKCTRCNEAASWKHDKRRWWCK SQ ECKKAFTPGITKMQQVPQQAQLQPLQNHNQIIPQLWDSQQNNSSQNTPPTQPQNNMNQIN SQ HQLLQQQHQQAQLQAHLNLTASNQQVPPQLQQQINGGLPNNNNSLITQNTLNSLSTSVSC SQ PPCPLCRGISSWKHDKKRYFCKECKKPFTPVGAGLSPSSSPSSPKKKSNITPITTSSTSS SQ SSSTPSIINNNNNNNANSSKNNTPKKQLSPPPSVLQSPSSSSISQSPLQLNYQTPTCSPN SQ PSLPSIGGNLNSQANSIKPDGGILISGLSPPKSSSSLNNLNSFSNTGALLSSNGINLANL SQ GNPLSQLNKKQKKRSDKDINDGGVQVLVSCVDTNVNNCSSIIPDGDSW XX SC SwissProt #P36417 XX FT 101 263 glutamine-rich region FT 267 305 asparagine-rich region FT 341 362 1st putative zinc finger (Cys4) FT 374 453 glutamine-rich region FT 483 504 2nd putative zinc finger (Cys4) XX SF pI 9.76 (calc.) XX FF developmentally regulated; FF confers inducibility to late gene promoters in response FF to extracellular cAMP during differentiation XX BS R00236; DIDI$CP1_01; Quality: 6; slime mould, Dictyostelium discoideum BS R01288; DIDI$CP2_01; Quality: 6; slime mould, Dictyostelium discoideum BS R00276; DIDI$DG17_01; Quality: 6; slime mould, Dictyostelium discoideum BS R00277; DIDI$DG17_02; Quality: 6; slime mould, Dictyostelium discoideum BS R01531; DIDI$UDPGPP_01; Quality: 6; slime mould, Dictyostelium discoideum XX DR EMBL: L29075; DDGBF(r). DR SwissProt: P36417; GBF_DICDI. XX RN [1] RA Schnitzler G. R., Fischer W. H., Firtel R. A. RT Cloning and characterization of the G-box binding RT factor, an essential component of the developmental RT switch between early and late development in Dictyostelium RL Genes Dev. 8:502-514 (1994). RN [2] RA Hjorth A. L., Khanna N. C., Firtel R. A. RT A trans-acting factor required for cAMP-induced gene RT expression in Dictyostelium is regulated developmentally and induced by cAMP RL Genes Dev. 3:747-759 (1989). XX // AC T00316 XX ID T00316 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA GBF XX SY G-box binding factor; XX OS tomato, Lycopersicon esculentum OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC asteridae; solanes; solanaceae XX SF isoforms GBF1, GBF2, GBF3 (Arabidopsis) XX BS R01315; AT$RS1A_01; Quality: 6; mouse-ear cress, Arabidopsis thaliana BS R01320; TO$RS3A_05; Quality: 6; tomato, Lycopersicon esculentum XX DR EMBL: X63894; ATGBF1(r). DR EMBL: X63895; ATGBF2(r). DR EMBL: X63896; ATGBF3(r). XX RN [1] RA Giuliano G., Pichersky E., Malik V. S., Timko M. P., RA Scolnik P. A., Cashmore A. R. RT An evolutionarily conserved protein binding sequence RT upstream of a plant light-regulated gene RL Proc. Natl. Acad. Sci. USA 85:7089-7093 (1988). XX // AC T00317 XX ID T00317 XX DT 15.10.92 (created); ewi. XX FA GC1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00623; RAT$GRH_17; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Tripputi P., Guerin S. L., Moore D. D. RT Two mechanism for the extinction of gene expression in hybrid cells RL Science 241:1205-1207 (1988). XX // AC T00318 XX ID T00318 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA GC2 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO GHF-1, Pit-1 XX BS R02850; MOUSE$SPIP12_02; Quality: 5; mouse, Mus musculus XX RN [1] RA Tripputi P., Guerin S. L., Moore D. D. RT Two mechanism for the extinction of gene expression in hybrid cells RL Science 241:1205-1207 (1988). RN [2] RA West B. L., Catanzaro D. F., Mellon S. H., Cattini RA P. A., Baxter J. D., Reudelhuber T. L. RT Interaction of a tissue-specific factor with an essential RT rat growth hormone gene promoter element RL Mol. Cell. Biol. 7:1193-1197 (1987). RN [3] RA Guerin S. L., Pothier F., Robidous S., Gosselin P., Parker M. G. RT Identification of a DNA-binding site for the transcription RT factor GC2 in the promoter region of the p12 gene RT and repression of its positive activity by upstream RT negative regulatory elements RL J. Biol. Chem. 265:22035-22043 (1990). XX // AC T00319 XX ID T00319 XX DT 15.10.92 (created); ewi. XX FA GC3 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00616; RAT$GRH_10; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Tripputi P., Guerin S. L., Moore D. D. RT Two mechanism for the extinction of gene expression in hybrid cells RL Science 241:1205-1207 (1988). XX // AC T00320 XX ID T00320 XX DT 04.12.92 (created); ewi. DT 04.03.97 (updated); ewi. XX FA GCF XX SY TCF-9; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 1.1.6.0.5. XX SZ 784 AA; 91 kDa (cDNA), 100 kDa (SDS) XX SQ MKKRVTNRERHWTHRRRRQRTRKKKKKKKRVLGRRALGPRPWLTGRKGLFGSARLIPATA SQ MAPRSRLLSLGRRGNFRSRVLRRKSRPLEEAARRWRDCPTGFGALVAGAGSGRAPGVPPK SQ RLPARTKAQNPEPLMCPQMKRIKYITPQKVRMIRVCLLTVLALLEKKNFHQQLRSQMQLL SQ FRQPAENVELARAQDDYISLDVQHTSSISVSRNEETSEESQEDEKQDTWEQQQMRKAVKI SQ IEERDIDLSCGSGSSKVKKFDTSISFPPVNLEIIKKQLNTRLTLLQETHRSHLREYEKYV SQ QDVKSSKSTIQNLESSSNQALNCKFYKSMKIYVENLIDCLNEKIINIQEIESSMHALLLK SQ QAMTFMKRRQDELKHESTYLQQLSRKDETSTSGNFSVDEKTQWILEEIESRRTKRRQARV SQ LSGNCNHQEGTSSDDELPSAEMIDFQKSQGDILQKQKKVFEEVQDDFCNIQNILLKFQQW SQ REKFPDSYYEAFISLCIPKLLNPLIRVQLIDWNPLKLESTGLKEMPWFKSVEEFMDSSVE SQ DSKKESSSDKKVLSAIINKTIIPRLTDFVEFLWDPLSTSQTTSLITHCRVILEEHSTCEN SQ EVSKSRQDLLKSIVSRMKKAVEDDVFIPLYPKSAVENKTSPHSKFQERQFWSGLKLFRNI SQ LLWNGLLTDDTLQELGLGKLLNRYLIIALLNATPGPDVVKKCNQVAACLPEKWFENSAMR SQ TSIPQLENFIQFLLQSAHKLSRSEFRDEVEEIILILVKIKALNQAESFIGEHHLDHLKSL SQ IKED XX SC SwissProt #P16383 XX FT 719 740 potential leucine zipper (ML3) FT 1 78 DNA-binding domain? (SwissProt) FT 2 86 basic region FT 23 29 lysine heptamer FT 359 380 potential leucine zipper (LMLL) XX CP widespread XX FF repressor at GC-rich sequences [2]; FF negative regulator of EGF receptor gene [2]; FF rapidly induced by phorbol ester within 1h, declining within 6h [1]; XX BS R02639; CHICK$BAC_06; Quality: 1; chick, Gallus gallus BS R02159; GCF$CONS_01; Quality: 6 BS R02644; GCF$CONS_02; Quality: 6 BS R02643; HS$CANP_01; Quality: 6; human, Homo sapiens BS R02641; HS$EGFR_21; Quality: 6; human, Homo sapiens BS R02642; HS$EGFR_22; Quality: 6; human, Homo sapiens XX DR EMBL: M29204; HSBFDNA(r). DR SwissProt: P16383; GCF_HUMAN. DR PIR: A33633; A33633. XX RN [1] RA Johnson A. C., Kageyama R., Popescu N. C., Pastan I. RT Expression and chromosomal localization of the gene RT for the human transcription repressor GCF RL J. Biol. Chem. 267:1689-1694 (1992). RN [2] RA Kageyama R., Pastan I. RT Molecular Cloning and Characterization of a Human RT DNA Binding Factor That Represses Transcription RL Cell 59:815-825 (1989). XX // AC T00321 XX ID T00321 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GCN4 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0008; bZIP; 1.1.1.5.1. XX SZ 31 kDa XX SQ MSEYQPSLFALNPMGFSPLDGSKSTNENVSASTSTAKPMVGQLIFDKFIKTEEDPIIKQD SQ TPSNLDFDFALPQTATAPDAKTVLPIPELDDAVVESFFSSSTDSTPMFEYENLEDNSKEW SQ TSLFDNDIPVTTDDVSLADKAIESTEEVSLVPSNLEVSTTSFLPTPVLEDAKLTQTRKVK SQ KPNSVVKKSHHVGKDDESRLDHLGVVAYNRKQRSIPLSPIVPESSDPAALKRARNTEAAR SQ RSRARKLQRMKQLEDKVEELLSKNYHLENEVARLKKLVGER XX SC SwissProt #P03069 XX FT 231 249 basic region FT 253 274 leucine zipper (L4) XX SF mutagenesis studies: DNA binding and non-binding mutants SF AA in positions 228, 236 and 239 are involved in the SF discrimination between GCN4- and C/EBP-sites XX FF activator of genes involved in protein and purine biosynthesis; FF significant enhancement of dimerization by Tax XX IN T00321; GCN4; yeast, Saccharomyces cerevisiae. XX MX M00038; F$GCN4 MX M00204; F$GCN4_C XX BS R04113; GCN4$CONS_01; Quality: 2 BS R01383; SV$SV40_15; Quality: 6; SV40, simian virus 40 BS R01394; SV$SV40_26; Quality: 6; SV40, simian virus 40 BS R04022; Y$ADE4_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R04023; Y$ADE4_02; Quality: 1; yeast, Saccharomyces cerevisiae BS R04024; Y$ADE4_03; Quality: 1; yeast, Saccharomyces cerevisiae BS R02919; Y$ARO7_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R00644; Y$HIS3_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R00645; Y$HIS3_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R00646; Y$HIS3_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R00647; Y$HIS3_04; Quality: 2; yeast, Saccharomyces cerevisiae BS R00648; Y$HIS3_05; Quality: 2; yeast, Saccharomyces cerevisiae BS R00649; Y$HIS3_06; Quality: 2; yeast, Saccharomyces cerevisiae BS R00651; Y$HIS4_08; Quality: 2; yeast, Saccharomyces cerevisiae BS R00655; Y$HIS4_12; Quality: 2; yeast, Saccharomyces cerevisiae BS R00656; Y$HIS4_13; Quality: 2; yeast, Saccharomyces cerevisiae BS R00657; Y$HIS4_14; Quality: 2; yeast, Saccharomyces cerevisiae BS R00829; Y$ILV1_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R00830; Y$ILV1_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R00831; Y$ILV1_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R00832; Y$ILV2_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R02022; Y$TRP4_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R02023; Y$TRP4_02; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: K02205; SCGCN4(g). DR SwissProt: P03069; GCN4_YEAST. DR PIR: A03605; RGBYA2. DR PDB: 1zta; LEUCINE ZIPPER MONOMER (NMR, 20 STRUCTURES)OF GCN4. DR PDB: 2dgc; GCN4 BASIC DOMAIN, LEUCINE ZIPPER COMPLEXED WITH ATF/CREB. DR PDB: 2dgc; GCN4 BASIC DOMAIN, LEUCINE ZIPPER COMPLEXED WITH ATF/CREB. DR PDB: 2dgc; GCN4 BASIC DOMAIN, LEUCINE ZIPPER COMPLEXED WITH ATF/CREB. DR PDB: 2zta; LEUCINE ZIPPER MONOMER (NMR, 20 STRUCTURES)OF GCN4. XX RN [1] RA Pu W. T., Struhl K. RT Highly conserved residues in the bZIP domain of yeast RT GCN4 are not essential for DNA binding RL Mol. Cell. Biol. 11:4918-4926 (1991). RN [2] RA van Heeckeren W. J., Sellers J. W., Struhl K. RT Role of the conserved leucines in the leucine zipper RT dimerization motif of yeast GCN4 RL Nucleic Acids Res. 20:3721-3724 (1992). RN [3] RA Suckow M., von Wilcken-Bergmann B., Mueller-Hill B. RT The DNA binding specificity of the basic region of RT the yeast transcriptional activator GCN4 can be changed RT by substitution of a single amino acid RL Nucleic Acids Res. 21:2081-2086 (1993). RN [4] RA Vincent A. C., Struhl K. RT ACR1, a yeast ATF/CREB repressor RL Mol. Cell. Biol. 12:5394-5405 (1992). RN [5] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [6] RA Johnson P. F. RT Identification of C/EBP basic region residues involved RT in DNA sequence recognition and half-site spacing preference RL Mol. Cell. Biol. 13:6919-6930 (1993). RN [7] RA Fodor E. J. B., Yen T. S. B., Rutter W. J. RT A Mammalian Viral Enhancer Confers Transcriptional Regulation in Yeast RL J. Biol. Chem. 263:9569-9572 (1988). RN [8] RA Kouzarides T., Ziff E. RT Leucine zippers of fos, jun and GCN4 dictate dimerization RT specificity and thereby control DNA binding RL Nature 340:568-571 (1989). RN [9] RA Hope I. A., Struhl K. RT Functional dissection of a eukaryotic transcriptional RT activator protein, GCN4 of yeast RL Cell 46:885-894 (1986). RN [10] RA Hill D. E., Hope I. A., Macke J. P., Struhl K. RT Saturation Mutagenesis of the Yeast his3 Regulatory RT Site: Requirements for Transcriptional Induction and RT for Binding by GCN4 Activator Protein RL Science 234:451-457 (1986). RN [11] RA Struhl K. RT The DNA-binding domains of the jun oncoprotein and RT the yeast GCN4 transcriptional activator protein are functionally homologous RL Cell 50:841-846 (1987). RN [12] RA Mueller P. P., Harashima S., Hinnebusch A. G. RT A segment of GCN4 mRNA containing the upstream AUG RT codons confers translational control upon a heterologous yeast transcript RL Proc. Natl. Acad. Sci. USA 84:2863-2867 (1987). RN [13] RA Williams N. P., Mueller P. P., Hinnebusch A. G. RT The positive regulatory function of the 5'-proximal RT open reading frames in GCN4 mRNA can be mimicked by RT jeterologous, short coding sequences RL Mol. Cell. Biol. 8:3827-3836 (1988). RN [14] RA Roussou I., Thireos G., Hauge B. M. RT Transcriptional-translational regulatory circuit in RT Saccharomyces cerevisiae which involves the GCN4 transcriptional RT activator and the GCN2 protein kinase RL Mol. Cell. Biol. 8:2132-2139 (1988). RN [15] RA Tzamarias D., Roussou I., Thireos G. RT Coupling of GCN4 mRNA translational activation with RT decreased rates of polypeptide chain initiation RL Cell 57:947-954 (1989). RN [16] RA Hope I. A., Mahadevan S., Struhl K. RT Structural and functional characterization of the RT short acidic transcriptional activation region of yeast GCN4 protein RL Nature 333:635-640 (1988). RN [17] RA Hope I. A., Struhl K. RT GCN4, a eukaryotic transcriptional activator protein, RT binds as a dimer to target DNA RL EMBO J. 6:2781-2784 (1987). RN [18] RA O'Shea E. K., Rutkowski R., Kim P. S. RT Evidence that the leucine zipper is a coiled coil RL Science 243:538-542 (1989). RN [19] RA Brandl C. J., Struhl K. RT Yeast GCN4 transcriptional activator protein interacts RT with RNA polymerase II in vitro RL Proc. Natl. Acad. Sci. USA 86:2652-2656 (1989). RN [20] RA Agre P., Johnson P. F., McKnight S. L. RT Cognate DNA binding specificity retained after leucine RT zipper exchange between GCN4 and C/EBP RL Science 246:922-926 (1989). RN [21] RA Oliphant A. R., Brandl C. J., Struhl K. RT Defining the sequence specificity of DNA- binding RT proteins by selecting binding sites from random-sequence RT oligonucleotides: analysis of yeast GCN4 protein RL Mol. Cell. Biol. 9:2944-2949 (1989). RN [22] RA Saudek V., Pastore A., Morelli , Castiglione M. A., RA Frank R., Gausepohl H., Gibson T., Weih F., Roesch P. RT Solution structure of the DNA-binding domain of the RT yeast transcriptional activator protein GCN4 RL Protein Engineering 4:3-10 (1990). RN [23] RA Hu J. C., O'Shea E. K., Kim P. S., Sauer R. T. RT Sequence requirements for coiled-coils: Analysis with RT lambda repressor-GCN4 leucine zipper fusions RL Science 250:1400-1403 (1990). RN [24] RA Weiss M. A., Ellenberger T., Wobbe C. R., Lee J. P., RA Harrison S. C., Struhl K. RT Folding transition in the DNA-binding domain of GCN4 RT on specific binding to DNA RL Nature 347:575-578 (1990). RN [25] RA Gartenberg M. R., Ampe C., Steitz T. A., Crothers D. M. RT Molecular characterization of the GCN4-DNA complex RL Proc. Natl. Acad. Sci. USA 87:6034-6038 (1990). RN [26] RA Oliviero S., Struhl K. RT Synergistic transcriptional enhancement does not depend RT on the number of acidic activation domains bound to the promoter RL Proc. Natl. Acad. Sci. USA 88:224-228 (1991). RN [27] RA O'Shea E. K., Klemm J. D., Kim P. S., Alber T. RT X-ray structure of the GCN4 leucine zipper, a two-stranded, RT parallel coiled coil RL Science 254:539-544 (1991). RN [28] RA Tzamarias D., Pu W. T., Struhl K. RT Mutations in the bZIP domain of yeast GCN4 that alter RT DNA-binding specificity RL Proc. Natl. Acad. Sci. USA 89:2007-2011 (1992). RN [29] RA Ellenberger T., Brandl C. J., Struhl K., Harrison S. C. RT The GCN4 basic region leucine zipper binds DNA as RT a dimer of uninterrupted helices: Crystal structure RT of the protein-DNA complex RL Cell 71:1223-1237 (1992). RN [30] RA Suckow M., von Wilcken-Bergmann B., Mueller-Hill B. RT The DNA binding specificity of the basic region of RT the yeast transcriptional activator GCN4 can be changed RT by substitution of a single amino acid RL Nucleic Acids Res. 21:2081-2086 (1993). RN [31] RA O'Donoghue S. I., Junius F. K., King G. F. RT Determination of the structure of symmetric coiled-coil RT proteins from NMR data: application of the leucine RT zipper proteins Jun and GCN4 RL Protein Engineering 6:557-564 (1993). RN [32] RA Suckow M., von Wilcken-Bergmann B., Mueller-Hill B. RT Identification of three residues in the basic region RT of bZIP proteins GCN4, C/EBP and TAF-1 that are involved RT in specific DNA binding RL EMBO J. 12:1193-1200 (1993). RN [33] RA Kim J., Tzamarias D., Ellenberger T., Harrison S. C., Struhl K. RT Adaptability at the protein-DNA interface is an important RT aspect of sequence recognition by bZIP proteins RL Proc. Natl. Acad. Sci. USA 90:4513-4517 (1993). RN [34] RA Kornitzer D., Raboy B., Kulka R. G., Fink G. R. RT Regulated degradation of the transcription factor Gcn4 RL EMBO J. 13:6021-6030 (1994). RN [35] RA Suckow M., Madan A., Kisters-Woike B., von Wilcken-Bergmann RA B., Mueller-Hill B. RT Creating new DNA binding specificities in the yeast RT transcriptional activator GCN4 by combining selected RT amino acid substitutions RL Nucleic Acids Res. 22:2198-2208 (1994). RN [36] RA Rolfes R. J., Hinnebusch A. G. RT Translation of the yeast transcriptional activator RT GCN4 is stimulated by purine limitation: Implications RT for activation of the protein kinase GCN2 RL Mol. Cell. Biol. 13:5099-5111 (1993). RN [37] RA Drysdale C. M., DueZas E., Jackson B. M., Reusser RA U., Braus G. H., Hinnebusch A. G. RT The transcriptional activator GCN4 contains multiple RT activation domains that are critically dependent on hydrophobic amino acids RL Mol. Cell. Biol. 15:1220-1233 (1995). RN [38] RA Kim J., Struhl K. RT Determinants of half-site spacing preferences that RT distinguish AP-1 and ATF/CREB bZIP domains RL Nucleic Acids Res. 23:2531-2537 (1995). RN [39] RA Hinnebusch A. G. RT Mechanisms of gene regulation in the geneal control RT of amino acid biosynthesis in Saccharomyces cerevisiae RL Microbiol. Rev. 52:248-273 (1988). RN [40] RA Arndt K., Fink G. R. RT GCN4 protein, a positive transcription factor in yeast, RT binds general control promoters at all 5' TGACTC 3' sequences RL Proc. Natl. Acad. Sci. USA 83:8516-8520 (1986). RN [41] RA Hope I. A., Struhl K. RT GCN4 protein, synthesized in vitro, binds HIS3 regulatory RT sequences: implications for general control of amino RT acid biosynthetic genes in yeast RL Cell 43:177-188 (1985). RN [42] RA Schmidheini T., Moesch H.-U., Graf R., Braus G. H. RT A GCN4 protein recognition element is not sufficient RT for GCN4-dependent regulation of transcription in RT the ARO7 promoter of Saccharomyces cerevisiae RL Mol. Gen. Genet. 224:57-64 (1990). RN [43] RA Moesch H.-U., Graf R., Schmidheini T., Braus G. RT Three GCN4 responsive elements act synergistically RT as upstream and as TATA-like elements in the yeast TRP4 promoter RL EMBO J. 9:2951-2957 (1990). RN [44] RA Sellers J. W., Vincent A. C., Struhl K. RT Mutations that define the optimal half-site for binding RT yeast GCN4 activator protein and identify an ATF/CREB-like RT repressor that recognizes similar DNA sites RL Mol. Cell. Biol. 10:5077-5086 (1990). XX // AC T00322 XX ID T00322 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GCR1 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 844 AA; 94.3 kDa (gene) XX SQ MNFLTQAMSETFQGTNNRIKRNVRTQSVPSTSYNNGKESYGPNTNQLNALLSQLEQQTSV SQ DSTSTSSNFYSIAQYILQSYFKVNVDSLNSLKLVDLIVDQTYPDSLTLRKLNEGATGQPY SQ DYFNTVSRDADISKCPIFALTIFFVIRWSHPNPPISIENFTTVPLLDSNFISLNSNPLLY SQ IQNQNPNSNSSVKVSRSQTFEPSKELIDLVFPWLSYLKQDMLLIDRTNYKLYSLCELFEF SQ MGRVAIQDLRYLSQHPLLLPNIVTFISKFIPELFQNEEFKGIGSIKNSNNNALNNVTGIE SQ TQFLNPSTEEVSQKVDSYFMELSKKLTTENIRLSQEITQLKADMNSVGNVCNQILLLQRQ SQ LLSGNQAIGSKSENIVSSTGGGILILDKNSINSNVLSNLVQSIDPNHSKPNGQAQTHQRG SQ PKGQSHAQVQSTNSPALAPINMFPSLSNSIQPMLGTLAPQPQDIVQKRKLPLPGSIASAA SQ TGSPFSPSPVGESPYSKRFKLDDKPTPSQTALDSLLTKSISSPRLPLSTLANTAVTESFR SQ SPQQFQHSPDFVVGGSSSSTTENNSKKVNEDSPSSSSKLAERPRLPNNDSTTSMPESPTE SQ VAGDDVDREKPPESSKSEPNDNSPESKDPEKNGKNSNPLGTDADKPVPISNIHNSTEAAN SQ SSGTVTKTAPSFPQSSSKFEIINKKDTKAGPNEAIKYKLSRENKTIWDLYAEWYIGLNGK SQ SSIKKLIENYGWRRWKVSEDSHFFPTRRIIMDYIETECDRGIKLGRFTNPQQPREDIRKI SQ LVGDLEKFRINNGLTLNSLSLYFRNLTKNNKEICIFENFKNWNVRSMTEEEKLKYCKRRH SQ NTPS XX SC SwissProt #P07261 XX FF coactivator of RAP1; FF regulates genes encoding glycolytic enzymes XX MX M00046; F$GCR1_01 XX BS R04140; Y$ADH1_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R04138; Y$ENO1_05; Quality: 2; yeast, Saccharomyces cerevisiae BS R03806; Y$ENO2_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R04137; Y$PGK_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R04139; Y$PYK1_05; Quality: 2; yeast, Saccharomyces cerevisiae BS R04073; Y$TPI_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R04136; Y$TPI_03; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: M15253; SCGCR1(g). DR EMBL: M14145; SCGCR1X(g). DR SwissProt: P07261; GCR1_YEAST. DR PIR: A25079; A25079. XX RN [1] RA Holland M. J., Yokoi T., Holland J. P., Myambo K., Innis M. A. RT The GCR1 Gene Encodes a Positive Transcriptional Regulator RT of the Enolase and Glycerinaldehyde-3-Phosphate Dehydrogenase RT Gene Families in Saccharomyces cerevisiae RL Mol. Cell. Biol. 7:813-820 (1987). XX // AC T00323 XX ID T00323 XX DT 15.10.92 (created); ewi. XX FA G6 factor XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00333; AD$E2L_01; Quality: 6; adenovirus type 2 BS R00334; AD$E2L_02; Quality: 6; adenovirus type 2 XX RN [1] RA Goding C. R., Temperley S. M., Fisher F. RT Multiple transcription factors interact with the adenovirus-2 RT EII-late promoter: evidence for a new CCAAT recognition factor RL Nucleic Acids Res. 15:7761-7780 (1987). XX // AC T00324 XX ID T00324 XX DT 15.10.92 (created); ewi. XX FA GFII XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX BS R03856; GFII$CONS; Quality: 6 BS R00200; Y$CFES_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R00203; Y$CSVIII_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R00202; Y$CSVI_01; Quality: 4; yeast, Saccharomyces cerevisiae XX RN [1] RA Dorsman J. C., van Heeswijk W. C., Grivell L. A. RT Identification of two factors which bind to the upstream RT sequences of a number of nuclear genes coding for RT mitochondrial proteins and to genetic elements important RT for cell division in yeast RL Nucleic Acids Res. 16:7287-7301 (1988). XX // AC T00325 XX ID T00325 XX DT 15.10.92 (created); ewi. DT 13.08.96 (updated); ewi. XX FA Pit-1 XX SY GHF-1; Pit-1b; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; 3.1.2.1.1.2. XX SZ 291 AA; 32.9 kDa (cDNA) XX SQ MSCQAFTSADTFIPLNSDASATLPLIMHHSAAECLPVSNHATNVMSTATGLHYSVPSCHY SQ GNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPIHQPLLAEDPTAADFKQELRRKSKLVEE SQ PIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSF SQ KNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEQNKPS SQ SQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR XX SC SwissProt #P28069 XX FT 2 87 serine-/threonine-rich region (20/86) FT 125 198 POU-specific domain FT 214 273 POU homeo domain XX FF activator, stimulating cells proliferation of somatotrophs, FF lactotrophs, and thyrothrophs [2]; FF naturally occurring A158P mutant within helix 1 of FF POU2 has lost gene activation capability, but still FF stimulates proliferation causing hypopituitarism in FF homozygous individuals [2]; FF R271W mutation (C-terminal border of POUh) leads to FF a DNA-binding dominant inhibitor affecting heterozygous FF individuals causing GH, Prl and TSH deficiency and, FF thus, mental and physical retardation (CPHD, Combined FF Pituitary Hormone Deficiency) [2], [3], [5]; XX BS R02160; GHF1$CONS; Quality: 6 BS R00611; HS$GRH_05; Quality: 6; human, Homo sapiens BS R00612; HS$GRH_06; Quality: 6; human, Homo sapiens XX DR EMBL: X62429; HSPIT1(r). DR EMBL: D10216; HSPIT1GHF(r). DR SwissProt: P28069; HMP1_HUMAN. DR PIR: S18718; S18718. DR Compel: C00038 DR Compel: C00046 XX RN [1] RA Sharp Z. D., Helsel S., Cao Z., Barron E. A., Sanchez Y. RT DNA recognition element required for PUF-I mediated RT cell-type specific transcription of the rat prolactin gene RL Nucleic Acids Res. 17:2705-2722 (1989). RN [2] RA Pfäffle R. W., DiMattia G. E., Parks J. S., Brown RA M. R., Wit J. M., Jansen M., van der Nat H., van den RA Brande J. L., Rosenfeld M. G., Ingraham H. A. RT Mutation of the POU-specific domain of Pit-1 and hypopituitarism RT without pituitary hypoplasia RL Science 257:1118-1121 (1992). RN [3] RA Radovick S., Nations M., Du Y., Berg L. A., Weintraub RA B. D., Wondisford F. E. RT A mutation in the POU-homeodomain of Pit-1 responsible RT for Combined Pituitary Hormone Deficiency RL Science 257:1115-1118 (1992). RN [4] RA Pernasetti F. M., Wera S., Belayew A., Martial J. A. RT Cloning of a human GHF-1/PIT-1 cDNA variant RL Nucleic Acids Res. 21:3584-3584 (1993). RN [5] RA Ohta K., Nobukuni Y., Mitsubuchi H., Fujimoto S., RA Matsuo N., Inagaki H., Endo F., Matsuda I. RT Mutations in the Pit-1 gene in children with combined RT pituitary hormone deficiency RL Biochem. Biophys. Res. Commun. 189:851-855 (1992). RN [6] RA Hyman S. E., Comb M., Lin Y.-S., Pearlberg J., Green M. R., Goodman H. M. RT A Common trans-Acting Factor Is Involved in Transcriptional RT Regulation of Neurotransmitter Genes by Cyclic AMP RL Mol. Cell. Biol. 8:4225-4233 (1988). RN [7] RA Lefevre C., Imagawa M., Dana S., Grindlay J., Bodner M., Karin M. RT Tissue-specific expression of the human growth hormone RT gene is conferred in part by the binding of a specific trans-acting factor RL EMBO J. 6:971-981 (1987). RN [8] RA Bodner M., Karin M. RT A Pituitary-Specific Trans-Acting Factor Can Stimulate RT Transcription from the Growth Hormone Promoter in RT Extracts of Nonexpressing Cells RL Cell 50:267-275 (1987). RN [9] RA Bodner M., Castrillo J.-L., Theill L. E., Deerinck T., Ellisman M., Karin M. RT The Pituitary-Specific Transcription Factor GHF-1 RT Is a Homeobox-Containing Protein RL Cell 55:505-518 (1988). XX // AC T00326 XX ID T00326 XX DT 26.01.93 (created); hse. XX FA GHF-5 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R02161; GHF5$CONS; Quality: 6 XX RN [1] RA Schaufele F., West B. L., Reudelhuber T. RT Somatotroph- and lactotroph-specific interactions RT with the homeobox protein binding sites in the rat RT growth hormone gene promoter RL Nucleic Acids Res. 18:5235-5244 (1990). XX // AC T00327 XX ID T00327 XX DT 26.01.93 (created); hse. XX FA GHF-7 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP adult anterior pituary XX BS R02162; GHF7$CONS; Quality: 6 BS R02052; RAT$GRH_21; Quality: 6; rat, Rattus norvegicus BS R02053; RAT$GRH_22; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Schaufele F., West B. L., Reudelhuber T. RT Somatotroph- and lactotroph-specific interactions RT with the homeobox protein binding sites in the rat RT growth hormone gene promoter RL Nucleic Acids Res. 18:5235-5244 (1990). XX // AC T00328 XX ID T00328 XX DT 30.11.92 (created); ewi. DT 15.05.94 (updated); hwi; ewi. XX FA Gt XX SY Giant; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0008; bZIP; 1.1.0.0.1. XX FF repressor of eve stripe 2 element; FF repressor of hairy in stripe 1; FF activator of hairy in stripe 6 XX BS R02490; DROME$EVE_19; Quality: 6; fruit fly, Drosophila melanogaster BS R02491; DROME$EVE_20; Quality: 6; fruit fly, Drosophila melanogaster BS R02495; DROME$EVE_24; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: X61148; DMGIANT(g). DR Flybase: FBgn0001150; gt. XX RN [1] RA Small S., Kraut R., Hoey T., Warrior R., Levine M. RT Transcriptional regulation of a pair-rule stripe in Drosophila RL Genes Dev. 5:827-839 (1991). RN [2] RA Stanojevic D., Small S., Levine M. RT Regulation of segmentation stripe by overlapping activators RT and repressors in the Drosophila embryo RL Science 254:1385-1387 (1991). RN [3] RA Riddihough G., Ish-Horowicz D. RT Individual stripe regulatory elements in the Drosophila RT hairy promoter respond to maternal, gap, and pair-rule genes RL Genes Dev. 5:840-854 (1991). XX // AC T00329 XX ID T00329 XX DT 07.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Glass XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.2.3. XX SZ 604 AA XX SQ MGLLYKGSKLLNTILDSLEDQEGGAMYISCDVSNGGPVEPETGYVPNNPLFGLALDSPQE SQ ECAASCVGCLSCQGSTALPISSLTSSDFDCGGCFDPTIGVGVGIGGGHIQISTTPPASSG SQ NGSSNNGAGGGSSGNHGYWSTDEMASTFPGLPPLDIDPLPSLFPFSPCGASYNFAAGNPH SQ QAASLSYTVHPHQMLISPNSHNHGQMHSQHQQHQHQQSQVQASHVGNSLLQSSGGNNIGS SQ NGSAGGVANAASCYYETSAGTAAPPPPPAAAMYPSMSVNVSMNMTMHHGYGAGDAGGVPM SQ QCSQMNWTPPSNSTSAAAAAAAVNVLYPPLLSPGHYPASATYSFTADFRAPAPTGLGALP SQ PMTVGEKESPSPPANSSLAGYYPTGVGNQGYTPPHKSPTSYQAAALGLSLSAFEDEEDSN SQ EDLDGDEGSSGGEMKPNLCRLCGKTYARPSTLKTHLRTHSGERPYRCPDCNKSFSQAANL SQ TAHVRTHTGQKPFRCPICDRRFSQSSSVTTHMRTHSGERPYRCSSCKKSFSDSSTLTKHL SQ RIHSGEKPYQCKLCLLRFSQSGNLNRHMRVHGNNNSSNGSNGATGVGGESSTGSGVGGGN SQ SLLT XX SC SwissProt #P13360 XX SF 5 zinc finger motifs XX CP third-instar eye-imaginal disc XX FF activator for Rh1 and glass; FF required for normal photoreceptor cell development XX BS R02291; DROME$GL_01; Quality: 6; fruit fly, Drosophila melanogaster BS R02292; DROME$GL_02; Quality: 6; fruit fly, Drosophila melanogaster BS R02288; DROME$RH1_01; Quality: 6; fruit fly, Drosophila melanogaster BS R02289; DROME$RH1_02; Quality: 6; fruit fly, Drosophila melanogaster BS R02290; DROME$RH1_03; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: X15400; DMGLASS(g). DR SwissProt: P13360; GLAS_DROME. DR PIR: S05447; S05447. DR Flybase: FBgn0004618; gl. XX RN [1] RA Moses K., Rubin G. M. RT glass encodes a site-specific DNA-binding protein RT that is regulated in response to positional signals RT in the developing Drosophila eye RL Genes Dev. 5:583-593 (1991). XX // AC T00330 XX ID T00330 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GLI XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; 2.3.2.3.1. XX SZ 118 kDa XX SQ MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN SQ SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS SQ YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK SQ SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD SQ GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP SQ HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK SQ PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG SQ GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS SQ LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE SQ RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG SQ TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL SQ GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP SQ YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW SQ GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG SQ PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN SQ YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK SQ SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG SQ GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP SQ PNMAVGNMSVLLRSLPGETEFLNSSA XX SC SwissProt #P08151 XX SF 5 zinc finger motifs XX FF gene amplified in glioblastomas XX BS R01930; GLI$CONS; Quality: 6; human, Homo sapiens XX DR EMBL: X07384; HSGLI(r). DR SwissProt: P08151; GLI_HUMAN. DR PIR: S00672; TVHUGL. XX RN [1] RA Kinzler K. W., Vogelstein B. RT The GLI Gene Encodes a Nuclear Protein Which Binds RT Specific Sequences in the Human Genome RL Mol. Cell. Biol. 10:634-642 (1990). RN [2] RA Kinzler K. W., Ruppert J. M., Bigner S. H., Vogelstein B. RT The GLI gene is a member of the Kruppel family of zinc finger proteins RL Nature 332:371-374 (1988). RN [3] RA Ruppert J. M., Kinzler K. W., Wong A. J., Bigner S. RA H., Kao F.-T., Law M. L., Seuanez H. N., O'Brien S. J., Vogelstein B. RT The GLI-Kruppel family of human genes RL Mol. Cell. Biol. 8:3104-3113 (1988). XX // AC T00331 XX ID T00331 XX DT 10.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GLI3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; 2.3.2.3.2. XX SZ 1596 AA; 172 kDa (cDNA); 190 kDa (SDS) XX SQ MEAQSHSSTTTEKKKVENSIVKCSTRTDVSEKAVASSTTSNEDESPGQTYHRERRNAITM SQ QPQNVQGLSKVSEEPSTSSDERASLIKKEIHGSLPHVAEPSVPYRGTVFAMDPRNGYMEP SQ HYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHMTSALSSSPTYPDLPFIRISPHR SQ NPAAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISATRGLSPTDAPHAGVSPAEYYHQ SQ MALLTGQRSPYADIIPSAATAGTGAIHMEYLHAMDSTRFSSPRLSARPSRKRTLSISPLS SQ DHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHMH SQ QQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTSE SQ SAVSSTGDPMHNKRSKIKPDEDLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYET SQ NCHWEGCAREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH SQ TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT SQ HSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSHS SQ QSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPI SQ SNYSNSGLELPLTDGGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKL SQ ERLKQVNGMFPRLNPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTM SQ LNMLNRRDSSASTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPIST SQ DASRRSSEASQSDGLPSLLSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKTRLALL SQ GDALEPGVALPPVHAPRRCSDGGAHGYGRRHLQPHDALGHGVRRASDPVRTGSEGLALPR SQ VPRFSSLSSCNPPAMATSAEKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESLTM SQ DADANLNDEDFLPDDVVQYLNSQNQAGYEQHFPSALPDDSKVPHGPGDFDAPGLPDSHAG SQ QQFHALEQPCPEGSKTDLPIQWNEVSSGSADLSSSKLKCGPRPAVPQTRAFGFCNGMVVH SQ PQNPLRSGPAGGYQTLGENSNPYGGPEHLMLHNSPGSGTSGNAFHEQPCKAPQYGNCLNR SQ QPVAPGALDGACGAGIQASKLKSTPMQGSGGQLNFGLPVAPNESAGSMVNGMQNQDPVGQ SQ GYLAHQLLGDSMQHPGAGRPGQQMLGQISATSHINIYQGPESCLPGAHGMGSQPSSLAVV SQ RGYQPCASFGGSRRQAMPRDSLALQSGQLSDTSQTCRVNGIKMEMKGQPHPLCSNLQNYS SQ GQFYDQTVGFSQQDTKAGSFSISDASCLLQGTSAKNSELLSPGANQVTSTVDSLDSHDLE SQ GVQIDFDAIIDDGDHSSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPVAVHEHHQHGYR SQ GHEFFADLPSGRKQIPCSYAIGFRKKRLQPTEINRS XX SC SwissProt #P10071 XX SF 5 zinc finger motifs XX FF interrupted by translocations causing Greig syndrome XX DR EMBL: M20674; HSGLI3(g). DR EMBL: M57609; HSGLI3A(r). DR SwissProt: P10071; GLI3_HUMAN. DR PIR: A35927; A35927. DR PIR: B31201; B31201. XX RN [1] RA Vortkamp A., Gessler M., Grzeschik K.-H. RT GLI3 zinc finger gene interrupted by translocations RT in Greig syndrome families RL Nature 352:539-540 (1991). XX // AC T00332 XX ID T00332 XX DT 15.10.92 (created); ewi. XX FA GM-PBP-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01733; MOUSE$GMCSF_03; Quality: 6; mouse, Mus musculus XX RN [1] RA James R., Kazenwadel J. RT T-cell nuclei contain a protein that binds upstream RT of the murine granulocyte-macrophage colony-stimulating factor gene RL Proc. Natl. Acad. Sci. USA 86:7392-7396 (1989). XX // AC T00333 XX ID T00333 XX DT 15.10.92 (created); ewi. DT 14.02.97 (updated); ewi. XX FA GR XX SY GCR; GR-DBD (GR DNA-binding domain); glucocorticoid receptor; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.1.1.1. XX SZ 795 AA; 87.5 (cDNA); 89 kDa (SDS) [32], 90 kDa (SDS) SZ [33], 94 kDa (SDS) [32]; XX SQ MDSKESLAPPGRDEVPGSLLGQGRGSVMDFYKSLRGGATVKVSASSPSVAAASQADSKQQ SQ RILLDFSKGSTSNVQQRQQQQQQQQQQQQQQQQQQQPGLSKAVSLSMGLYMGETETKVMG SQ NDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSVPENPKSSTSATGCATPTEKEFPKT SQ HSDASSEQQNRKSQTGTNGGSVKLYPTDQSTFDLLKDLEFSAGSPSKDTNESPWRSDLLI SQ DENLLSPLAGEDDPFLLEGNTNEDCKPLILPDTKPKIKDTGDTILSSPSSVALPQVKTEK SQ DDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTAS SQ LSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDSLTSLGALNFPGRSVFSNGYSSPGMRP SQ DVSSPPSSSSAATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRN SQ DCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENPNKTIVP SQ AALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIL SQ GLRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSGNLLCFAPDLIINEQRMSLPCMYDQ SQ CKHMLFVSSELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIV SQ KREGNSSQNWQRFYQLTKLLDSMHEVVENLLTYCFQTFLDKTMSIEFPEMLAEIITNQIP SQ KYSNGNIKKLLFHQK XX SC SwissProt #P06536 XX FT 1 440 region A/B FT 106 318 trans-activating domain 1 (enh 2) [15]; FT 497 525 nuclear localization signal (NLS 1) FT 526 540 region D FT 540 795 region E, hormone-binding domain (HBD) FT 568 616 hsp90 contact region FT 526 555 trans-activating domain 2 FT 440 525 region C, DNA-binding domain (DBD) FT 568 616 hormone-binding domain (contains FT 2 sites of interaction with hsp90) XX SF data from crystal structure, CD, NMR of the DBD available [4], [37]; SF native folding of the DBD to full alpha-helix content SF requires zinc ions [54]; SF DNA-binding to a GRE half-site is suppressed by the A/B region SF first zinc finger binds specifically to GRE, the second SF enhances affinity [6]; SF free in solution, GR exists predominantly as homodimer [10]; SF AGRND in the second zinc finger mediates homodimerization SF and discrimination against DNA-binding of other nuclear receptors [4]; SF cooperative DNA-binding to repeated GREs requires SF trans-activating domain 1 [45]; XX FF mediates gene induction / repression by glucocorticoids [30], [11]; FF ligand binding leads to dissociation from hsp90 and FF allows nuclear translocation [34]; FF GR can act through composite elements where it cooperates FF with other transcription factors [36]; FF cooperating with AF1, AF2; FF represses Oct-1 DNA binding [42]; XX IN T00029; AP-1; human, Homo sapiens. IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T00333; GR; rat, Rattus norvegicus. IN T00644; Oct-1A; mouse, Mus musculus. IN T00990; FKBP59; human, Homo sapiens. IN T00992; Hsp90; human, Homo sapiens. IN T00993; hsp56; human, Homo sapiens. IN T01466; Oct-1; hamster, Cricetulus griseus. XX MX M00205; V$GRE_C XX BS R03533; AS$AP1_04; Quality: 1 BS R03531; AS$GR_04; Quality: 1 BS R03544; AS$GR_05; Quality: 2 BS R03545; AS$GR_06; Quality: 2 BS R03546; AS$GR_07; Quality: 2 BS R03547; AS$GR_08; Quality: 2 BS R03548; AS$GR_09; Quality: 2 BS R03549; AS$GR_10; Quality: 2 BS R00973; CHICK$LYS_01; Quality: 1; chick, Gallus gallus BS R00974; CHICK$LYS_02; Quality: 1; chick, Gallus gallus BS R00975; CHICK$LYS_03; Quality: 1; chick, Gallus gallus BS R00977; CHICK$LYS_05; Quality: 1; chick, Gallus gallus BS R00979; CHICK$LYS_07; Quality: 1; chick, Gallus gallus BS R00980; CHICK$LYS_08; Quality: 2; chick, Gallus gallus BS R00982; CHICK$LYS_10; Quality: 2; chick, Gallus gallus BS R00984; CHICK$LYS_12; Quality: 2; chick, Gallus gallus BS R00985; CHICK$LYS_13; Quality: 2; chick, Gallus gallus BS R02163; GR$CONS; Quality: 6 BS R03543; HIV1$HIV1_22; Quality: 2; HIV-1, human immunodeficiency virus type 1 BS R00737; HPV$HPV16_05; Quality: 1; HPV-16, human papilloma virus type 16 BS R00591; HS$GHA_03; Quality: 1; human, Homo sapiens BS R00593; HS$GHA_05; Quality: 6; human, Homo sapiens BS R00595; HS$GHA_07; Quality: 6; human, Homo sapiens BS R00613; HS$GRH_07; Quality: 2; human, Homo sapiens BS R01030; HS$MT2A_01; Quality: 2; human, Homo sapiens BS R03558; HS$OC_02; Quality: 2; human, Homo sapiens BS R01099; MMTV$MMTV_01; Quality: 2; MMTV, mouse mammary tumor virus BS R01100; MMTV$MMTV_02; Quality: 2; MMTV, mouse mammary tumor virus BS R01101; MMTV$MMTV_03; Quality: 2; MMTV, mouse mammary tumor virus BS R01102; MMTV$MMTV_04; Quality: 2; MMTV, mouse mammary tumor virus BS R01103; MMTV$MMTV_05; Quality: 2; MMTV, mouse mammary tumor virus BS R01104; MMTV$MMTV_06; Quality: 2; MMTV, mouse mammary tumor virus BS R01106; MMTV$MMTV_08; Quality: 6; MMTV, mouse mammary tumor virus BS R01107; MMTV$MMTV_09; Quality: 6; MMTV, mouse mammary tumor virus BS R01108; MMTV$MMTV_10; Quality: 6; MMTV, mouse mammary tumor virus BS R01109; MMTV$MMTV_11; Quality: 2; MMTV, mouse mammary tumor virus BS R01114; MMTV$MMTV_16; Quality: 2; MMTV, mouse mammary tumor virus BS R01115; MMTV$MMTV_17; Quality: 2; MMTV, mouse mammary tumor virus BS R01117; MMTV$MMTV_19; Quality: 2; MMTV, mouse mammary tumor virus BS R01119; MMTV$MMTV_21; Quality: 2; MMTV, mouse mammary tumor virus BS R01121; MMTV$MMTV_23; Quality: 2; MMTV, mouse mammary tumor virus BS R01130; MMTV$MMTV_32; Quality: 2; MMTV, mouse mammary tumor virus BS R01131; MMTV$MMTV_33; Quality: 2; MMTV, mouse mammary tumor virus BS R01132; MMTV$MMTV_34; Quality: 2; MMTV, mouse mammary tumor virus BS R01133; MMTV$MMTV_35; Quality: 2; MMTV, mouse mammary tumor virus BS R02961; MMTV$MMTV_37; Quality: 2; MMTV, mouse mammary tumor virus BS R01285; MOUSE$PLF_01; Quality: 1; mouse, Mus musculus BS R01547; RABBIT$UG_02; Quality: 2; rabbit, Oryctolagus cuniculus BS R01549; RABBIT$UG_04; Quality: 2; rabbit, Oryctolagus cuniculus BS R01550; RABBIT$UG_05; Quality: 2; rabbit, Oryctolagus cuniculus BS R01554; RABBIT$UG_09; Quality: 2; rabbit, Oryctolagus cuniculus BS R00579; RAT$A2UG_07; Quality: 1; rat, Rattus norvegicus BS R03534; RAT$A2UG_08; Quality: 2; rat, Rattus norvegicus BS R03535; RAT$A2UG_09; Quality: 2; rat, Rattus norvegicus BS R03536; RAT$A2UG_10; Quality: 2; rat, Rattus norvegicus BS R03537; RAT$A2UG_11; Quality: 2; rat, Rattus norvegicus BS R03538; RAT$A2UG_12; Quality: 2; rat, Rattus norvegicus BS R03539; RAT$A2UG_13; Quality: 2; rat, Rattus norvegicus BS R00425; RAT$AFEP_02; Quality: 1; rat, Rattus rattus BS R00426; RAT$AFEP_03; Quality: 1; rat, Rattus rattus BS R00427; RAT$AFEP_04; Quality: 1; rat, Rattus rattus BS R00428; RAT$AFEP_05; Quality: 1; rat, Rattus rattus BS R00429; RAT$AFEP_06; Quality: 1; rat, Rattus rattus BS R00433; RAT$AFEP_10; Quality: 1; rat, Rattus rattus BS R01698; RAT$AFEP_11; Quality: 4; rat, Rattus norvegicus BS R03890; RAT$ANF_02; Quality: 1; rat, Rattus norvegicus BS R03891; RAT$ANF_03; Quality: 1; rat, Rattus norvegicus BS R02021; RAT$CYTOPB_01; Quality: 6; rat, Rattus norvegicus BS R00584; RAT$GLUR_01; Quality: 2; rat, Rattus norvegicus BS R02793; RAT$PEPCK_17; Quality: 1; rat, Rattus norvegicus BS R01811; RAT$POMC_01; Quality: 2; rat, Rattus norvegicus BS R01812; RAT$POMC_02; Quality: 2; rat, Rattus norvegicus BS R01813; RAT$POMC_03; Quality: 2; rat, Rattus norvegicus BS R01814; RAT$POMC_04; Quality: 2; rat, Rattus norvegicus BS R01815; RAT$POMC_05; Quality: 2; rat, Rattus norvegicus BS R01480; RAT$TAT_01; Quality: 2; rat, Rattus norvegicus BS R01481; RAT$TAT_02; Quality: 1; rat, Rattus norvegicus BS R01482; RAT$TAT_03; Quality: 2; rat, Rattus norvegicus BS R01484; RAT$TAT_05; Quality: 2; rat, Rattus norvegicus BS R01473; RAT$TOA_01; Quality: 1; rat, Rattus norvegicus BS R01475; RAT$TOA_03; Quality: 1; rat, Rattus norvegicus XX DR EMBL: M14053; RNGCR(r). DR EMBL: Y00489; RNGRP(r). DR SwissProt: P06536; GCR_RAT. DR PIR: A24194; QRRTG. DR Compel: C00021 DR Compel: C00078 DR Compel: C00128 DR PDB: 1gdc; GLUCOCORTICOID RECEPTOR (DNA BINDING DOMAIN) GR-DBD RATTUS NORVEGICUS. DR PDB: 2gda; GLUCOCORTICOID RECEPTOR (DNA BINDING DOMAIN, GR-DBD) RATTUS NORVEGICUS. XX RN [1] RA Hecht A., Berkenstam A., Stroemstedt P.-E., Gustafsson J.-A., Sippel A. E. RT A progesterone responsive element maps to the far RT upstream steroid DNase hypersensitive site of chicken lysozyme chromatin RL EMBO J. 7:2063-2073 (1988). RN [2] RA von der Ahe D., Renoir J.-M., Buchou T., Baulieu E.-E., Beato M. RT Receptors for glucocorticosteroid and progesterone RT recognize distinct features of a DNA regulatory element RL Proc. Natl. Acad. Sci. USA 83:2817-2821 (1986). RN [3] RA Archer T. K., Hager G. L., Omichinski J. G. RT Sequence-specific DNA binding by glucocorticoid receptor RT zinc finger peptides RL Proc. Natl. Acad. Sci. USA 87:7560-7564 (1990). RN [4] RA Luisi B. F., Xu W. X., Otwinowski Z., Freedman L. RA P., Yamamoto K. R., Sigler P. B. RT Crystallographic analysis of the interaction of the RT glucocorticoid receptor with DNA RL Nature 352:497-505 (1991). RN [5] RA von der Ahe D., Janich S., Scheidereit C., Renkawitz RA R., Schuetz G., Beato M. RT Glucocorticoid and progesterone receptors bind the RT same sites in two hormonally regulated promoters RL Nature 313:706-709 (1985). RN [6] RA Haerd T., Kelenbach E., Boelens R., Maler B. A., Dahlmann RA K., Freedman L. P., Carlstedt-Duke J., Yamamoto K. RA R., Gustafsson J.-A., Kaptein R. RT Solution structure of the glucocorticoid receptor DNA-binding domain RL Science 249:157-160 (1990). RN [7] RA Karin M., Haslinger A., Holtgreve H., Richards R. RA I., Krauter P., Westphal H. M., Beato M. RT Characterization of DNA sequences through which cadmium RT and glucocorticoid hormones induce human metallothionein-IIA gene RL Nature 308:513-519 (1984). RN [8] RA Yang-Yen H.-F., Chambard J.-C., Sun Y.-L., Smeal T., RA Schmidt T. J., Drouin J., Karin M. RT Transcriptional interference between c-Jun and the RT glucocorticoid receptor: mutual inhibition of DNA RT binding due to direct protein-protein interaction RL Cell 62:1205-1215 (1990). RN [9] RA Lucibello F. C., Slater E. P., Jooss K. U., Beato M., Mueller R. RT Mutual transrepression of Fos and the glucocorticoid RT receptor: involvement of a functional domain in Fos which is absent in FosB RL EMBO J. 9:2827-2834 (1990). RN [10] RA Eriksson P., Wrange Oe. RT Protein-protein contacts in the glucocorticoid receptor RT homodimer influence its DNA binding properties RL J. Biol. Chem. 265:3535-3542 (1990). RN [11] RA Stroemstedt P.-E., Poellinger L., Gustafsson J.-A., Carlstedt-Duke J. RT The glucocorticoid receptor binds to a sequence overlapping RT the TATA box of the human osteocalcin promoter: A RT potential mechanism for negative regulation RL Mol. Cell. Biol. 11:3379-3383 (1991). RN [12] RA Haerd T., Kelenbach E., Boelens R., Maler B. A., Dahlmann RA K., Freedman L. P., Carlstedt-Duke J., Yamamoto K. RA R., Gustafsson J.-A., Kaptein R. RT Solution structure of the glucocorticoid receptor DNA-binding domain RL Science 249:157-160 (1990). RN [13] RA Howard K. J., Holley S. J., Yamamoto K. R., Distelhorst C. W. RT Mapping the HSP90 binding region of the glucocorticoid receptor RL J. Biol. Chem. 265:11928-11935 (1990). RN [14] RA Payvar F., DeFranco D., Firestone G. L., Edgar B., RA Wrange Oe., Okret S., Gustafsson J.-A., Yamamoto K. RT Sequence-Specific Binding of Glucocorticoid Receptor RT to MTV DNA at Sites within and Upstream of the Transcribed Region RL Cell 35:381-392 (1983). RN [15] RA Freedman L. P., Yoshinaga S. K., Vanderbilt J. N., Yamamoto K. RT In vitro transcription enhancement by purified derivates RT of the glucocorticoid receptor RL Science 245:298-301 (1989). RN [16] RA Scheidereit C., Beato M. RT Contacts between hormone receptor and DNA double helix RT within a glucocorticoid regulatory element of mouse mammary tumor virus RL Proc. Natl. Acad. Sci. USA 81:3029-3033 (1984). RN [17] RA Chalepakis G., Postma J. P. M., Beato M. RT A model for hormone receptor binding to the mouse RT mammary tumor virus regulatory element based on hydroxyl RT radical footprinting RL Nucleic Acids Res. 16:10237-10248 (1988). RN [18] RA Perlmann T., Wrange Oe. RT Specific glucocorticoid receptor binding to DNA reconstituted RT in a nucleosome RL EMBO J. 7:3073-3079 (1988). RN [19] RA Willmann T., Beato M. RT Steroid-free glucocorticoid receptor binds specifically RT to mouse mammary tumor virus DNA RL Nature 324:688-691 (1986). RN [20] RA Scheidereit C., Geisse S., Westphal H. M., Beato M. RT The glucocorticoid receptor binds to defined nucleotide RT sequences near the promoter of mouse mammary tumor virus RL Nature 304:749-752 (1983). RN [21] RA Wrang Oe., Erikson P., Perlmann T. RT The Purified Activated Glucocorticoid Receptor Is a Homodimer RL J. Biol. Chem. 264:5253-5259 (1989). RN [22] RA Danesch U., Gloss B., Schmid W., Schuetz G., Schuele R., Renkawitz R. RT Glucocorticoid induction of the rat tryptophan oxygenase RT gene is mediated by two widely separated glucocorticoid-responsive elements RL EMBO J. 6:625-630 (1987). RN [23] RA Jantzen H.-M., Straehle U., Gloss B., Stewart F., RA Schmid W., Boshart M., Miksicek R., Schuetz G. RT Cooperativity of Glucocorticoid Response Elements RT Located Far Upstream of the Tyrosine Aminotransferase Gene RL Cell 49:29-38 (1987). RN [24] RA Becker P. B., Gloss B., Schmid W., Straehle W., Schuetz G. RT In vivo protein-DNA interactions in a glucocorticoid RT response element require the presence of the hormone RL Nature 324:686-688 (1986). RN [25] RA Tsai S. Y., Carlstedt-Duke J., Weigel N. L., Dahlmann RA K., Gustafsson J.-A., Tsai M.-J., O'Malley B. W. RT Molecular interactions of steroid hormone receptor RT with its enhancer element: evidence for receptor dimer formation RL Cell 55:361-369 (1988). RN [26] RA Jantzen K., Fritton H. P., Igo-Kemenes T., Espel E., RA Janich S., Cato A. C. B., Mugele K., Beato M. RT Partial overlapping of binding sequences for steroid RT hormone receptors and DNaseI hypersensitive sites RT in the rabbit uteroglobin gene region RL Nucleic Acids Res. 15:4535-4552 (1987). RN [27] RA Bailly A., Le Page C., Rauch M., Milgrom E. RT Sequence-specific DNA binding of the progesterone RT receptor to the uteroglobin gene: effects of hormone, RT antihormone and receptor phosphorylation RL EMBO J. 5:3235-3241 (1986). RN [28] RA Cato A. C. B., Geisse S., Wenz M., Westphal H. M., Beato M. RT The nucleotide sequences recognized by the glucocorticoid RT receptor in the rabbit uteroglobin gene region are RT located far upstream from the initiation of transcription RL EMBO J. 3:2771-2778 (1984). RN [29] RA Kutoh E., Stroemstedt P.-E., Poellinger L. RT Functional interference between the ubiquitous and RT constitutive octamer transcription factor 1 (OTF-1) RT and the glucocorticoid receptor by direct protein-protein RT interaction involving the homeo subdomain of OTF-1 RL Mol. Cell. Biol. 12:4960-4969 (1992). RN [30] RA Dong Y., Cairns W., Okret S., Gustafsson J.-A. RT A glucocorticoid-resistant rat hepatoma cell variant RT contains functional glucocorticoid receptors RL J. Biol. Chem. 265:7526-7531 (1990). RN [31] RA Miesfeld R., Rusconi S., Godowski P. J., Maler B. RA A., Okret S., Wikstr•m A.-C., Gustafsson J.-A., Yamamoto K. R. RT Genetic complementation of a glucocorticoid receptor RT deficiency by expression of cloned receptor cDNA RL Cell 46:389-399 (1986). RN [32] RA Wrange O., Carlstedt-Duke J., Gustafsson J.-A. RT Purification of the glucocorticoid receptor from the rat liver cytosol RL J. Biol. Chem. 254:9284-9289 (1979). RN [33] RA Wetsphal H. M., Moldenhauer G., Beato M. RT Monoclonal antibodies to the rat liver glucocorticoid receptor RL EMBO J. 1:1467-1471 (1982). RN [34] RA Pratt W. B. RT The role of the heat shock proteins in regulating RT the function, folding and trafficking of the glucocorticoid receptor RL J. Biol. Chem. 268:21455-21458 (1993). RN [35] RA Picard D., Yamamoto K. R. RT Two signals mediate hormone-dependent nuclear localization RT of the glucocorticoid receptor RL EMBO J. 6:3333-3340 (1987). RN [36] RA Schuele R., Muller M., Kaltschmidt C., Renkawitz R. RT Many transcription factors interact synergistacally with steroid receptors RL Science 242:1418- (1988). RN [37] RA Eriksson M. A. L., Berglund H., Haerd T., Wilsson L. RT A comparison of 15N NMR relaxion measurement with RT a molecular dynamics simulation: backbone dynamics RT of the glucocorticoid receptor DNA-binding domain RL Protein 17:375-390 (1993). RN [38] RA Miesfeld R., Okret S., Wistroem A.-C., Gustafsson J.-A., Yamamoto K. R. RT Characterization of a steroid hormone receptor gene RT and mRNA in wild-type and mutant cells RL Nature 312:779-781 (1984). RN [39] RA Schulman G., Bodine P. V., Litwack G. RT Modulators of th eglucocorticoid receptor also regulate RT mineralcorticoid receptor function RL Biochemistry 31:1734-1741 (1992). RN [40] RA Chang C., Kokontis J., Chang C.-T., Liao S. RT Cloning and sequence analysis of the rat ventral prostate RT glucocorticoid receptor cDNA RL Nucleic Acids Res. 15:9603 (1987). RN [41] RA Gutman A., Wasylyk B. RT The collagenase gene promoter contains a TPA and oncogene-responsive RT unit encompassing the PEA3 and AP-1 binding sites RL EMBO J. 9:2241-2246 (1990). RN [42] RA Brueggemeier U., Kalff M., Franke S., Scheidereit C., Beato M. RT Ubiquitous transcription factor OTF-1 mediates induction RT of the MMTV promoter through synergistic interaction with hormone receptors RL Cell 64:565-572 (1991). RN [43] RA Nemoto T., Mason G. F., Wilhelmsson A., Cuthill S., RA Hapgood J., Gustafsson J. A., Poellinger L. RT Activation of the Dioxin and Glucocorticoid Receptors RT to a DNA Binding State under Cell-free Conditions RL J. Biol. Chem. 256:2269-2277 (1990). RN [44] RA Drouin J., Trifiro M. A., Plante R. K., Nemer M., Eriksson P., Wrange Oe. RT Glucocorticoid Receptor Binding to a Specific DNA RT Sequence Is Required for Hormone-Dependent Repression RT of Pro-Opiomelanocortin Gene Transcription RL Mol. Cell. Biol. 9:5305-5314 (1989). RN [45] RA Schmid W., Straehle U., Schuetz G., Schmitt J., Stunnenberg H. RT Glucocorticoid receptor binds cooperatively to adjacent recognition sites RL EMBO J. 8:2257-2263 (1989). RN [46] RA Guertin M., LaRue H., Bernier D., Wrange O., Chevrette RA M., Gingras M.-C., Belanger L. RT Enhancer and Promoter Elements Directing Activation RT and Glucocorticoid Repression of the alpha1-Fetoprotein Gene in Hepatocytes RL Mol. Cell. Biol. 8:1398-1407 (1988). RN [47] RA Okret S., Poellinger L., Dong Y., Gustafsson J.-A. RT Down-regulation of glucocorticoid receptor mRNA by RT glucocorticoid hormones and recognition by the receptor RT of a specific binding sequence within a receptor cDNA clone RL Proc. Natl. Acad. Sci. USA 83:5899-5903 (1986). RN [48] RA Akerblom I., Slater E. P., Beato M., Baxter J. D., Mellon P. L. RT Negative regulation by glucocorticoids through interference RT with a cAMP responsive enhancer RL Science 241:350-353 (1988). RN [49] RA Moore D. D., Marks A. R., Buckley D. I., Kapler G., Payvar F., Goodman H. M. RT The first intron of the human growth hormone gene RT contains a binding site for glucocorticoid receptor RL Proc. Natl. Acad. Sci. USA 82:699-702 (1985). RN [50] RA Imai E., Stromstedt P.-E., Quinn P. G., Carlstedt-Duke RA J., Gustafsson J.-A., Granner D. K. RT Characterization of a complex glucocorticoid response RT unit in the phosphoenolpyruvate carboxykinase gene RL Mol. Cell. Biol. 10:4712-4719 (1990). RN [51] RA Gloss B., Bernard H. U., Seedorf K., Klock G. RT The upstream regulatory region of the human papilloma RT virus-16 contains an E2 protein-independent enhancer RT which is specific for cervical carcinoma cells and RT regulated by glucocorticoid hormones RL EMBO J. 6:3735-3743 (1987). RN [52] RA Archer T. K., Cordingley M. G., Wolford R. G., Hager G. L. RT Transcription factor access is mediated by accurately RT positioned nucleosomes on the mouse mammary tumor virus promoter RL Mol. Cell. Biol. 11:688-698 (1991). RN [53] RA Cairns W., Cairns C., Pongratz I., Poellinger L., Okret S. RT Assembly of a glucocorticoid receptor complex prior RT to DNA binding enhances its specific interaction with RT a glucocorticoid response element RL J. Biol. Chem. 266:11221-11226 (1991). RN [54] RA Freedman L. P., Luisi B. F., Korszun Z. R., Basavappa RA R., Sigler P. B., Yamamoto K. R. RT The function and structure of the metal coordination RT sites within the glucocorticoid receptor DNA binding domain RL Nature 334:543-546 (1988). RN [55] RA Jaiswal A. K., Haaparanta T., Luc P.-V., Schembri J., Adesnik M. RT Glucocorticoid regulation of a phenobarbital-inducible RT cytochrome P-450 gene: the presence of a functional RT glucocorticoid response element in the 5'-flanking region of the CYP2B2 gene RL Nucleic Acids Res. 18:4237 (1990). XX // AC T00334 XX ID T00334 XX DT 15.10.92 (created); ewi. XX FA GR XX SY glucocorticoid receptor; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0002; CC (rec); . XX IN T00029; AP-1; human, Homo sapiens. IN T00133; c-Jun; human, Homo sapiens. IN T00990; FKBP59; human, Homo sapiens. IN T00992; Hsp90; human, Homo sapiens. IN T00993; hsp56; human, Homo sapiens. XX MX M00205; V$GRE_C XX BS R01576; CHICK$VIT2_09; Quality: 4; chick, Gallus gallus BS R02163; GR$CONS; Quality: 6 BS R01483; RAT$TAT_04; Quality: 1; rat, Rattus norvegicus XX RN [1] RA Saluz H. P., Jiricny J., Jost J. P. RT Genomic sequencing reveals a positive correlation RT between the kinetics of strand-specific DNA demethylation RT of the overlapping estradiol/glucocorticoid-receptor RT binding sites and the rate of avian vitellogenin mRNA synthesis RL Proc. Natl. Acad. Sci. USA 83:7167-7171 (1986). XX // AC T00335 XX ID T00335 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA GR XX SY glucocorticoid receptor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.1.1.1. XX SZ 783 AA; 86.1 kDa (cDNA), 86 kDa (SDS), 90-94 kDa (SDS) [7]; XX SQ MDSKESLAPPGRDEVPSSLLGRGRGSVMDLYKTLRGGATVKVSASSPSVAAASQADSKQQ SQ RILLDFSKGSASNAQQQQQQQQPQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLG SQ LSSGETDFRLLEESIANLNRSTSRPENPKSSTPAAGCATPTEKEFPQTHSDPSSEQQNRK SQ SQPGTNGGSVKLYTTDQSTFDILQDLEFSAGSPGKETNESPWRSDLLIDENLLSPLAGED SQ DPFLLEGDVNEDCKPLILPDTKPKIQDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVI SQ KQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFN SQ VIPPIPVGSENWNRCQGSGEDNLTSLGAMNFAGRSVFSNGYSSPGMRPDVSSPPSSSSTA SQ TGPPPKLCLVCSDEASVCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNC SQ PACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENANKTIVPAALPQLTPTLVS SQ LLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMT SQ LLQYSWMFLMAFALGWRSYRQASGNLLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQ SQ RLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQR SQ FYQLTKLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNIKKLLF SQ HQK XX SC SwissProt #P06537 XX FT 1 426 region A/B FT 194 293 trans-activating domain FT 426 505 region C, DNA-binding domain FT 485 512 nuclear localization signal 1 (NLS1) FT 535 783 region E, hormone-binding domain XX SF the first zinc finger of the DBD binds specifically SF to the GRE, the second enhances the affinity [3]; SF essential for GRE/ERE discrimination: knuckle of the SF 1st zinc finger (GS vs. EG) XX IN T00029; AP-1; human, Homo sapiens. IN T00133; c-Jun; human, Homo sapiens. IN T00335; GR; mouse, Mus musculus. IN T01454; Hsp90; mouse, Mus musculus. XX MX M00205; V$GRE_C XX BS R02163; GR$CONS; Quality: 6 BS R01104; MMTV$MMTV_06; Quality: 2; MMTV, mouse mammary tumor virus BS R01146; MOMLV$MOMULV_13; Quality: 4; Mo-MuLV, moloney murine leukemia virus BS R01147; MOMLV$MOMULV_14; Quality: 4; Mo-MuLV, moloney murine leukemia virus BS R01312; MOUSE$RAS1_01; Quality: 6; mouse, Mus musculus BS R01313; MOUSE$RAS1_02; Quality: 6; mouse, Mus musculus BS R01645; RADLV$RLV_04; Quality: 6; RadLV (BL/VL3 Kaplan radiation leukemia virus) XX DR EMBL: X04435; MMGCRR(r). DR SwissProt: P06537; GCR_MOUSE. DR PIR: A25691; A25691. DR Compel: C00002 DR Compel: C00043 DR Compel: C00074 DR Compel: C00075 XX RN [1] RA Diamond M. I., Miner J. N., Yoshinaga S. K., Yamamoto K. R. RT Transcription factor interactions: selectors of positive RT or negative regulation from a single DNA element RL Science 249:1266-1267 (1990). RN [2] RA Housley P. R., Sanchez E. R., Danielsen M., Ringold G. M., Pratt W. B. RT Evidence that the conserved region in the steroid RT binding domain of the glucocorticoid receptor is required RT for both optimal binding of hsp90 and protection from RT proteolytic cleavage. A two-site model for hsp90 binding RT to the steroid binding domain RL J. Biol. Chem. 265:12778-12781 (1990). RN [3] RA Danielsen M., Hinck L., Ringold G. M. RT Two amino acids within the knuckle of the first zinc RT finger specificy DNA response element activation by RT the glucocorticoid receptor RL Cell 57:1131-1138 (1989). RN [4] RA Sanchez E. R., Hirst M., Scherrer L. C., Tang H.-Y., RA Welsh M. J., Harmon J. M., Simons jr. S. S., Ringold G. M., Pratt W. B. RT Hormone-free mouse glucocorticoid receptors overexpressed RT in chinese hamster ovary cells are localized to the RT nucleus and are associated with both hsp70 and hsp90 RL J. Biol. Chem. 265:20123-20130 (1990). RN [5] RA Sanchez E. R. RT Hsp56: A novel heat shock protein associated with RT untransformed steroid receptor complexes RL J. Biol. Chem. 265:22067-22070 (1990). RN [6] RA Speck N. A., Baltimore D. RT Six distinct nuclear factors interact with the 75-base-pair RT repeat of the moloney murine leukemia virus enhancer RL Mol. Cell. Biol. 7:1101-1110 (1987). RN [7] RA Hollenberg S. M., Weinberger C., Ong E. S., Cerelli RA G., Oro A., Lebo R., Thompson E. B., Rosenfeld G. M., Evans R. M. RT Primary structure and expression of a functional human RT glucocorticoid receptor cDNA RL Nature 318:635-641 (1985). RN [8] RA Danielsen M., Northrop P., Ringold G. M. RT The mouse glucocorticoid receptor: mapping of functional RT domains by cloning, sequencing and expression of wild-type RT and mutant receptor proteins RL EMBO J. 5:2513-2522 (1986). RN [9] RA Gehring U., Hotz A. RT Photoaffinity labeling and partial proteolysis of RT wild-type and variant glucocorticoid receptors RL Biochemistry 22:4013-4018 (1983). RN [10] RA Rexin M., Busch M., Gehring U. RT Protein components of the nonactivated glucocorticoid receptor RL J. Biol. Chem. 266:24601-24604 (1991). RN [11] RA Sanchez E. R., Toft D. O., Schlesinger M. J., Pratt W. B. RT Evidence that the 90-kDa-phosphoprotein associated RT with the untransformed L-cell glucocorticoid receptor RT is a murine heat shock protein RL J. Biol. Chem. 260:12398-12401 (1985). RN [12] RA Chen D., Stallup M. R. RT The hormone-binding role of the 2 cysteins near the RT C-terminus of the mouse glucocorticoid receptor RL J. Biol. Chem. 269:7914-7918 (1994). RN [13] RA Gorska-Flipot I., Jolicoeur P. RT DNA-Binding Proteins That Interact with the Long Terminal RT Repeat of Radiation Leukemia Virus RL J. Virol. 64:1566-1572 (1990). XX // AC T00336 XX ID T00336 XX DT 15.10.92 (created); ewi. XX FA GR XX SY glucocorticoid receptor; XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX CL C0002; CC (rec); . XX IN T00029; AP-1; human, Homo sapiens. IN T00133; c-Jun; human, Homo sapiens. IN T00990; FKBP59; human, Homo sapiens. IN T00992; Hsp90; human, Homo sapiens. IN T00993; hsp56; human, Homo sapiens. XX MX M00205; V$GRE_C XX BS R01659; FELV$FELV_04; Quality: 6; FeLV, feline leukemia virus BS R02163; GR$CONS; Quality: 6 XX RN [1] RA Fulton R., Plumb M., Shield L., Neil J. C. RT Structural Diversity and Nuclear Protein Binding Sites RT in the Long Terminal Repeats of Feline Leukemia Virus RL J. Virol. 64:1675-1682 (1990). XX // AC T00337 XX ID T00337 XX DT 15.10.92 (created); ewi. DT 14.02.97 (updated); ewi. XX FA GR alpha XX SY GR; glucocorticoid receptor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); 2.1.1.1.1. XX SZ 777 AA; 85.7 kDa (cDNA), 88-94 kDa (SDS) XX SQ MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR SQ LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK SQ LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN SQ VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN SQ SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV SQ YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG SQ SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL SQ CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK SQ CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE SQ PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW SQ MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY SQ EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK SQ LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK XX SC SwissProt #P04150 XX FT 421 486 region C, DNA-binding domain (DBD) [15]; FT 487 555 region D FT 556 777 region E, hormone-binding domain (HBD) FT 532 697 hsp90-contacting region FT 78 262 trans-activating domain (tau1) [16]; FT 526 556 trans-activating domain (tau2) [17]; FT 728 777 replaced by 728-742 in GR beta XX SF 2 splice variants alpha and beta (742 AA), differing SF in their C-termini [12]; SF the first zinc finger binds specifically to the GRE, SF the second enhances the affinity [1]; SF AGRND within the second finger mediates homodimerization SF and contributes to the differential DNA-binding specificity SF against other nuclear receptors [8]; SF G->E-variant (after 3rd Cys of the zinc finger region) SF recognizes GRE as well as ERE SF AGRND -> KYEGK (between 1st Cys doublet of the 2nd SF zinc finger): conversion to a TRE-binding receptor SF cooperative binding to a double GRE through tau1 domain XX FF activator or repressor in response to glucocorticoid hormones [19]; FF cooperating with other transcription factors, it may FF act through composite elements [18], [4]; FF can be inhibited by physical interaction with c-Jun or c-Fos [21], [2]; FF represses Oct-1 DNA binding [10]; FF leukemic cell lethality through DBD (1st zinc finger and 1/2 of second) [7]; XX IN T00029; AP-1; human, Homo sapiens. IN T00123; c-Fos; human, Homo sapiens. IN T00133; c-Jun; human, Homo sapiens. IN T00337; GR alpha; human, Homo sapiens. IN T00644; Oct-1A; mouse, Mus musculus. IN T00990; FKBP59; human, Homo sapiens. IN T00992; Hsp90; human, Homo sapiens. IN T00993; hsp56; human, Homo sapiens. IN T01466; Oct-1; hamster, Cricetulus griseus. IN T01920; GR beta; human, Homo sapiens. XX MX M00205; V$GRE_C XX BS R03199; AS$GR_01; Quality: 2 BS R03526; AS$GR_02; Quality: 6 BS R03530; AS$GR_03; Quality: 6 BS R03531; AS$GR_04; Quality: 1 BS R03561; AS$GR_11; Quality: 1 BS R03562; AS$GR_12; Quality: 1 BS R00973; CHICK$LYS_01; Quality: 1; chick, Gallus gallus BS R00974; CHICK$LYS_02; Quality: 1; chick, Gallus gallus BS R00975; CHICK$LYS_03; Quality: 1; chick, Gallus gallus BS R02163; GR$CONS; Quality: 1 BS R00591; HS$GHA_03; Quality: 6; human, Homo sapiens BS R00593; HS$GHA_05; Quality: 6; human, Homo sapiens BS R00595; HS$GHA_07; Quality: 6; human, Homo sapiens BS R03551; HS$IL6_04; Quality: 1; human, Homo sapiens BS R03552; HS$IL6_05; Quality: 1; human, Homo sapiens BS R03555; HS$IL6_08; Quality: 1; human, Homo sapiens BS R03556; HS$IL6_09; Quality: 1; human, Homo sapiens BS R01480; RAT$TAT_01; Quality: 2; rat, Rattus norvegicus BS R01481; RAT$TAT_02; Quality: 1; rat, Rattus norvegicus XX DR EMBL: M10901; HSGCRA(r). DR EMBL: X03225; HSGCRAR(r). DR EMBL: M73050; HSGRA1(g). DR SwissProt: P04150; GCRA_HUMAN. DR SwissProt: P04150; GCRB_HUMAN. DR PIR: A93370; QRHUGA. DR Compel: C00073 DR Compel: C00130 XX RN [1] RA Haerd T., Kelenbach E., Boelens R., Maler B. A., Dahlmann RA K., Freedman L. P., Carlstedt-Duke J., Yamamoto K. RA R., Gustafsson J.-A., Kaptein R. RT Solution structure of the glucocorticoid receptor DNA-binding domain RL Science 249:157-160 (1990). RN [2] RA Schuele R., Rangarajan P., Kliewer S., Ransone L. RA J., Bolado J., Yang N., Verma I. M., Evans R. M. RT Functional antagonism between oncoprotein c-Jun and RT the glucocorticoid receptor RL Cell 62:1217-1226 (1990). RN [3] RA Wright A. P. H., Gustafsson J.-A. RT Mechanism of synergistic transcriptional transactivation RT by the human glucocorticoid receptor RL Proc. Natl. Acad. Sci. USA 88:8283-8287 (1991). RN [4] RA Chatterjee V. K. K., Madison L. D., Mayo S., Jameson J. L. RT Repression of the human glycoprotein hormone Alpha-subunit RT gene by glucocorticoids: Evidence for receptor interactions RT with limiting transcriptional activators RL Mol. Endocrinol. 5:100-110 (1991). RN [5] RA Ku Tai P.-K., Albers M. W., Chang H., Faber L. E., Schreiber S. L. RT Association of a 59-kilodalton immunophilin with the RT glucocorticoid receptor complex RL Science 256:1315-1318 (1992). RN [6] RA Sanchez E. R. RT Hsp56: A novel heat shock protein associated with RT untransformed steroid receptor complexes RL J. Biol. Chem. 265:22067-22070 (1990). RN [7] RA Nazareth L. V., Harbour D. V., Thompson E. B. RT Mapping the human glucocorticoid receptor for leukemic cell death RL J. Biol. Chem. 266:12976-12980 (1991). RN [8] RA Dahlmann-Wright K., Wright A., Gustafsson J.-A., Carlstedt-Duke J. RT Interaction of the glucocorticoid receptor DNA-binding RT domain with DNA as a dimer is mediated by a short RT segment of five amino acids RL J. Biol. Chem. 266:3107-3112 (1991). RN [9] RA Umesono K., Evans R. M. RT Determinants of target gene specificity for steroid/thyroid RT hormone receptors RL Cell 57:1139-1146 (1989). RN [10] RA Kutoh E., Stroemstedt P.-E., Poellinger L. RT Functional interference between the ubiquitous and RT constitutive octamer transcription factor 1 (OTF-1) RT and the glucocorticoid receptor by direct protein-protein RT interaction involving the homeo subdomain of OTF-1 RL Mol. Cell. Biol. 12:4960-4969 (1992). RN [11] RA Weinberger C., Hollenberg S. M., Rosenfeld G. M., Evans R. M. RT Domain structure of human glucocorticoid receptor RT and its relationship to the v-erb-A oncogene product RL Nature 318:670-672 (1985). RN [12] RA Hollenberg S. M., Weinberger C., Ong E. S., Cerelli RA G., Oro A., Lebo R., Thompson E. B., Rosenfeld G. M., Evans R. M. RT Primary structure and expression of a functional human RT glucocorticoid receptor cDNA RL Nature 318:635-641 (1985). RN [13] RA Peattie D. A., Harding M. W., Fleming M. A., DeCenzo RA M. T., Lippke J. A., Livingston D. J., Benasutti M. RT Expression and characterization of the human FKBP52, RT an immunophilin that associates with the 90-kDa heat RT shock protein and is a component of steroid receptor proteins RL Proc. Natl. Acad. Sci. USA 89:10974-10978 (1992). RN [14] RA Hollenberg S. M., Giguere V., Segul P., Evans R. M. RT Colocalization of DNA-binding and transcriptional RT activation functions in the human glucocorticoid receptor RL Cell 49:39-46 (1987). RN [15] RA Giguere V., Hollenberg S. M., Rosenfeld M. G., Evans R. M. RT Functional domains of the human glucocorticoid receptor RL Cell 46:645-652 (1986). RN [16] RA Oro A. E., Hollenberg S. M., Evans R. M. RT Transcriptional inhibition by a glucocorticoid receptor-beta-galactosidase RT fusion protein RL Cell 55:1109-1114 (1988). RN [17] RA Hollenberg S. M., Evans R. M. RT Multiple and cooperative trans-activation domains RT of the human glucocorticoid receptor RL Cell 55:899-906 (1988). RN [18] RA Straehle U., Schmid W., Schuetz G. RT Synergistic action of the glucocorticoid receptor with transcription factors RL EMBO J. 7:3389-3395 (1988). RN [19] RA Akerblom I., Slater E. P., Beato M., Baxter J. D., Mellon P. L. RT Negative regulation by glucocorticoids through interference RT with a cAMP responsive enhancer RL Science 241:350-353 (1988). RN [20] RA Alksnis M., Barkhem T., Stroemstedt P.-E., Ahola H., RA Kutoh E., Gustafsson J.-A., Poellinger L., Nilsson S. RT High level expression of functional full length and RT truncated glucocorticoid receptor in chinese hamster ovary cells RL J. Biol. Chem. 266:10078-10085 (1991). RN [21] RA Jonat C., Rahmsdorf H. J., Park K.-K., Cato A. C. RA B., Gebel S., Ponta H., Herrlich P. RT Antitumor promotion and antiinflammation: Down-modulation RT of AP-1 (Fos/Jun) activity by glucocorticoid hormone RL Cell 62:1189-1204 (1990). RN [22] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). XX // AC T00339 XX ID T00339 XX DT 15.10.92 (created); ewi. XX FA GT-1 XX OS pea, Pisum sativum OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC rosidae; fabales; fabaceae XX BS R01316; PEA$RS3A_01; Quality: 6; pea, Pisum sativum BS R01317; PEA$RS3A_02; Quality: 6; pea, Pisum sativum BS R01318; PEA$RS3A_03; Quality: 6; pea, Pisum sativum BS R01319; PEA$RS3A_04; Quality: 6; pea, Pisum sativum XX RN [1] RA Green P. J., Kay S. A., Chua N.-H. RT Sequence-specific interaction of a pea nuclear factor RT with light-responsive elements upstream of the rbcS-3A gene RL EMBO J. 6:2543-2549 (1987). XX // AC T00340 XX ID T00340 XX DT 15.10.92 (created); ewi. XX FA GT-IC XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF different from AP-3 XX // AC T00341 XX ID T00341 XX DT 15.10.92 (created); ewi. XX FA GT-IIA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa,BJA-B,MOLT-4) XX BS R01420; SV$SV40_52; Quality: 6; SV40, simian virus 40 XX RN [1] RA Xiao J. H., Davidson I., Ferrandon D., Rosales R., RA Vigneron M., Macchi M., Ruffenach F., Chambon P. RT One cell-specific and three ubiquitous proteins bind RT in vitro to overlapping motifs in the domain B1 of the SV40 enhancer RL EMBO J. 6:3005-3013 (1987). XX // AC T00342 XX ID T00342 XX DT 15.10.92 (created); ewi. XX FA GT-IIBalpha XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa,BJA-B,MOLT-4) XX BS R00853; MOUSE$IGH_19; Quality: 2; mouse, Mus musculus BS R01418; SV$SV40_50; Quality: 6; SV40, simian virus 40 XX RN [1] RA Xiao J. H., Davidson I., Ferrandon D., Rosales R., RA Vigneron M., Macchi M., Ruffenach F., Chambon P. RT One cell-specific and three ubiquitous proteins bind RT in vitro to overlapping motifs in the domain B1 of the SV40 enhancer RL EMBO J. 6:3005-3013 (1987). XX // AC T00343 XX ID T00343 XX DT 15.10.92 (created); ewi. XX FA GT-IIBbeta XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa,BJA-B,MOLT-4) XX BS R01419; SV$SV40_51; Quality: 6; SV40, simian virus 40 XX RN [1] RA Xiao J. H., Davidson I., Ferrandon D., Rosales R., RA Vigneron M., Macchi M., Ruffenach F., Chambon P. RT One cell-specific and three ubiquitous proteins bind RT in vitro to overlapping motifs in the domain B1 of the SV40 enhancer RL EMBO J. 6:3005-3013 (1987). XX // AC T00345 XX ID T00345 XX DT 20.10.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA H XX SY Hairy; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0010; bHLH; 1.2.5.1.1. XX SZ 337 AA; 37.0 kDa (cDNA) XX SQ MVTGVTAANMTNVLGTAVVPAQLKETPLKSDRRSNKPIMEKRRRARINNCLNELKTLILD SQ ATKKDPARHSKLEKADILEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSR SQ FPGIEPAQRRRLLQHLSNCINGVKTELHQQQRQQQQQSIHAQMLPSPPSSPEQDSQQGAA SQ APYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQLLQHQQQQQQLAV SQ AAAAAAAAAAQQQPMLVSMPQRTASTGSASSHSSAGYESAPGSSSSCSYAPSSPANSSYE SQ PMDIKPSVIQRVPMEQQPLSLVIKKQIKEEEQPWRPW XX SC SwissProt #P14003 XX FT 32 44 basic region FT 45 89 helix-loop-helix domain FT 149 162 glutamine-rich region (9/14) FT 218 237 glutamine-rich region (14/20) FT 239 250 alanine-rich region (11/12) FT 263 298 serine-/threonine-rich region (18/36) FT 334 337 WRPW motif XX SF WRPW peptide is essential for Hairy activity [7] in SF being required for for interaction with Groucho protein SF which mediates maternal influences on neurogenesis, SF segmentation and sex determination [3]; SF may also bind specifically to non-canonical sequences [2]; XX FF transcriptional repressor [1]; FF pair-rule gene product, involved in embryonic segmentation FF and adult bristle patterning [8], [7], [1], [2]; FF repression of Ac by H is essential for peripheral FF nervous system development [1]; FF hairy gene is regulated by dorsal and bicoid (maternal effect genes) [5]; FF expressed in 7 regularly spaced stripe along the anterior-posterior FF egg axis plus 12-15 nuclei in region 0 (95-85% egg length) [5]; XX MX M00067; I$HAIRY_01 XX BS R04159; DROME$AC_02; Quality: 1; fruit fly, Drosophila melanogaster XX DR EMBL: X15904; DMHAIRG(g). DR EMBL: X15905; DMHAIRR(r). DR SwissProt: P14003; HAIR_DROME. DR PIR: S06956; S06956. DR Flybase: FBgn0001168; h. XX RN [1] RA Van Doren M., Bailey A. M., Esnayra J., Ede K., Posakony J. W. RT Negative regulation of proneural gene activity: hairy RT is a direct transcriptional repressor of achaete RL Genes Dev. 8:2729-2742 (1994). RN [2] RA Ohsako S., Hyer J., Panganiban G., Oliver I., Caudy M. RT hairy function as a DNA-binding helix--loop--helix RT repressor of Drosophila sensory organ formation RL Genes Dev. 8:2743-2755 (1994). RN [3] RA Paroush Z., Finley Jr. R. L., Kidd T., Wainwright RA S. M., Ingham P. W., Brent R., Ish-Horowicz D. RT Groucho is required for Drosophila neurogenesis, segmentation, RT and sex determination and interacts directly with RT hairy-related bHLH proteins RL Cell 79:805-815 (1994). RN [4] RA Nuesslein-Volhard C., Wieschaus E. RT Mutations affecting segment number and polarity in Drosophila RL Nature 287:795-801 (1980). RN [5] RA Ingham P. W., Howard K. R., Ish-Horowicz D. RT Transcription pattern of the Drosophila segmentation gene hairy RL Nature 318:439-445 (1985). RN [6] RA Ish-Horowicz D., Howard K. R., Pinchin S. M., Ingham P. W. RT Molecular and genetic analysis of the hairy locus in Drosophila RL Cold Spring Harbor Symp. Quant. Biol. 50:135-144 (1985). RN [7] RA Wainwright S. M., Ish-Horowicz D. RT Point mutations in the Drosophila hairy gene demonstrate RT in vivo requirements for basic, helix-loop-helix, and WRPW domains RL Mol. Cell. Biol. 12:2475-2483 (1992). RN [8] RA Rushlow C. A., Hogan A., Pinchin M. A., Howe K. M., RA Lardelli M., Ish-Horowicz D. RT The Drosophila hairy protein acts in both segmentation RT and bristle patterning and shows homology to N-myc RL EMBO J. 8:3095-3103 (1989). XX // AC T00346 XX ID T00346 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA HAP1 XX SY CYP1; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0005; C6; 2.4.1.0.4. XX SZ 1483 AA; 164 kDa (gene) XX SQ MSNTPYNSSVPSIASMTQSSVSRSPNMHTATTPGANTSSNSPPLHMSSDSSKIKRKRNRI SQ PLSCTICRKRKVKCDKLRPHCQQCTKTGVAHLCHYMEQTWAEEAEKELLKDNELKKLRER SQ VKSLEKTLSKVHSSPSSNSLKSYNTPESSNLFMGSDEHTTLVNANTGSASSASHMHQQQQ SQ QQQQQEQQQDFSRSANANANSSSLSISNKYDNDELDLTKDFDLLHIKSNGTIHLGATHWL SQ SIMKGDPYLKLLWGHIFAMREKLNEWYYQKNSYSKLKSSKCPINHAQAPPSAAAAATRKC SQ PVDHSAFSSGMVAPKEETPLPRKCPVDHTMFSSGMIPPREDTSSQKRCPVDHTMYSAGMM SQ PPKDETPSPFSTKAMIDHNKHTMNPPQSKCPVDHRNYMKDYPSDMANSSSNPASRCPIDH SQ SSMKNTAALPASTHNTIPHHQPQSGSHARSHPAQSRKHDSYMTESEVLATLCEMLPPKRV SQ IALFIEKFFKHLYPAIPILDEQNFKNHVNQMLSLSSMNPTVNNFGMSMPSSSTLENQPIT SQ QINLPKLSDSCNLGILIIILRLTWLSIPSNSCEVDLGEESGSFLVPNESSNMSASALTSM SQ AKEESLLLKHETPVEALELCQKYLIKFDELSSISNNNVNLTTVQFAIFYNFYMKSASNDL SQ TTLTNTNNTGMANPGHDSESHQILLSNITQMAFSCGLHRDPDNFPQLNATIPATSQDVSN SQ NGSKKANPSTNPTLNNNMSAATTNSSSRSGSADSRSGSNPVNKKENQVSIERFKHTWRKI SQ WYYIVSMDVNQSLSLGSPRLLRNLRDFSDTKLPSASRIDYVRDIKELIIVKNFTLFFQID SQ LCIIAVLNHILNVSLARSVRKFELDSLINLLKNLTYGTENVNDVVSSLINKGLLPTSEGG SQ SVDSNNDEIYGLPKLPDILNHGQHNQNLYADGRNTSSSDIDKKLDLPHESTTRALFFSKH SQ MTIRMLLYLLNYILFTHYEPMGSEDPGTNILAKEYAQEALNFAMDGYRNCMIFFNNIRNT SQ NSLFDYMNVILSYPCLDIGHRSLQFIVCLILRAKCGPLTGMRESSIITNGTSSGFNSSVE SQ DEDVKVKQESSDELKKDDFMKDVNLDSGDSLAEILMSRMLLFQKLTKQLSKKYNYAIRMN SQ KSTGFFVSLLDTPSKKSDSKSGGSSFMLGNWKHPKVSNMSGFLAGDKDQLQKCPVYQDAL SQ GFVSPTGANEGSAPMQGMSLQGSTARMGGTQLPPIRSYKPITYTSSNLRRMNETGEAEAK SQ RRRFNDGYIDNNSNNDIPRGISPKPSNGLSSVQPLLSSFSMNQLNGGTIPTVPSLTNITS SQ QMGALPSLDRITTNQINLPDPSRDEAFDNSIKQMTPMTSAFMNANTTIPSSTLNGNMNMN SQ GAGTANTDTSANGSALSTLTSPQGSDLASNSATQYKPDLEDFLMQNSNFNGLMINPSSLV SQ EVVGGYNDPNNLGRNDAVDFLPVDNVEIDGLVDFYRADFPIWE XX SC SwissProt #P12351 XX FT 244 444 heme-binding site XX SF acidic region XX FF central regulator for genes involved in oxygen metabolism; FF heme-stimulated DNA-binding; FF heme binding-site masks DNA-binding domain in the absence of inducer XX BS R03327; HAP1$CONS; Quality: 6 BS R00253; Y$CTT1_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R03326; Y$CYB2_02; Quality: 4; yeast, Saccharomyces cerevisiae BS R00257; Y$CYC1_04; Quality: 1; yeast, Saccharomyces cerevisiae BS R00265; Y$CYC7_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R03498; Y$CYT1_01; Quality: 1; yeast, Saccharomyces cerevisiae XX DR EMBL: X13793; SCCYP1(g). DR EMBL: J03152; SCHAP1(g). DR SwissProt: P12351; CYP1_YEAST. DR PIR: S59400; RGBYH1. DR PDB: 1pyc; CYP1 (HAP1) DNA-BINDING DOMAIN (RESIDUES 60-100). XX RN [1] RA Schneider J. C., Guarente L. RT Regulation of the yeast CYT1 gene encoding cytochrome RT c1 by HAP1 and HAP2/3/4 RL Mol. Cell. Biol. 11:4934-4942 (1991). RN [2] RA Winkler H., Adam G., Mattes E., Schanz M., Hartig A., Ruis H. RT Co-ordinate control of synthesis of mitochondrial RT and non-mitochondrial hemoproteins: a binding site RT for the HAP1 (CYP1) protein in the UAS region of the RT yeast catalase T gene (CTT1) RL EMBO J. 7:1799-1804 (1988). RN [3] RA Pfeifer K., Arcangioli B., Guarente L. RT Yeast HAP1 activator competes with the factor RC2 RT for binding to the upstream activation site UAS1 of the CYC1 gene RL Cell 49:9-18 (1987). RN [4] RA Kim K. S., Pfeifer K., Powell L., Guarente L. RT Internal deletions in the yeast transcriptional activator RT HAP1 have opposite effects at two sequence elements RL Proc. Natl. Acad. Sci. USA 87:4524-4528 (1990). RN [5] RA Pfeifer K., Prezant T., Guarente L. RT Yeast HAP1 Activator Binds to Two Upstream Activation RT Sites of Different Sequence RL Cell 49:19-27 (1987). RN [6] RA Prezant T., Pfeifer K., Guarente L. RT Organization of the Regulatory Region of the Yeast RT CYC7 Gene: Multiple Factors Are Involved in Regulation RL Mol. Cell. Biol. 7:3252-3259 (1987). RN [7] RA Lodi T., Guiard B. RT Complex transcriptional regulation of the Saccharomyces RT cerevisiae CYB2 gene encoding cytochrome b2: CYP1(HAP1) RT activator binds to the CYB2 upstream activation site UAS1-B2 RL Mol. Cell. Biol. 11:3762-3772 (1991). XX // AC T00347 XX ID T00347 XX DT 26.01.93 (created); ewi. DT 27.08.96 (updated); ewi. XX FA HAP2 XX SY CBF-B (rat); CP1B (human, rat); NF-YA (mouse); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 1.6.1.0.2. XX SZ 257 AA, 258 AA; 28 kDa (cDNA); 25 kDa (sedim.) XX SQ MEQYTANSNSSTEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPL SQ MVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAV SQ QVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTIL SQ QQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMV SQ PGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLH SQ ESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS XX SC SwissProt #P23511 XX SF glutamine-rich region XX IN T00087; CBF-A; rat, Rattus norvegicus. IN T00350; HAP3; yeast, Saccharomyces cerevisiae. IN T00351; HAP4; yeast, Saccharomyces cerevisiae. IN T00616; NF-YB; mouse, Mus musculus. IN T01263; HAP3; fission yeast, Schizosaccharomyces pombe. XX DR EMBL: M59079; HSHAP2A(r). DR SwissProt: P23511; CBFB_HUMAN. DR PIR: A39123; A39123. DR PIR: S22816; S22816. XX RN [1] RA Chodosh L. A., Baldwin A. S., Carthew R. W., Sharp P. A. RT Human CCAAT-Binding Proteins Have Heterologous Subunits RL Cell 53:11-24 (1988). RN [2] RA Becker D. M., Fikes J. D., Guarente L. RT A cDNA encoding a human CCAAT-binding protein cloned RT by functional complementation in yeast RL Proc. Natl. Acad. Sci. USA 88:1968-1972 (1991). XX // AC T00348 XX ID T00348 XX DT 12.03.93 (created); ewi. DT 22.08.96 (updated); ewi. XX FA HAP2 XX SY CBF-B; CP1B; NF-YA; Php2; XX OS fission yeast, Schizosaccharomyces pombe OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 1.6.1.0.2. XX SZ 334 AA; 34.9 kDa (gene) XX SQ MNPYEPVEGLYVNAKQYHRILKRREARAKLEERLRGVQTTKKPYLHESRHKHAMRRPRGP SQ GGRFLTADKVSKLRAQEAAEAAANGGSTGDDVNATNANDATVPATVSSEVTHTSEGYADS SQ NDSRPSSISNSSESPAPINSATASMSPANNTSGNNITSPNVRGELDMSGNIAMSGGPTNT SQ ASTSGPVPHDMTVLPQTDSNTSNLMSSGSQLGSFATASTNGNNSTTTTTSSAAHPGSFHK SQ GTNDYSSTLAGNEHSAFPGLDVYHDDSVSAGAAFIPHNPMDSIDHLDVNDPTATGLPVLP SQ ASDIDPLNLTGNTQDSMIIGQQTYPSHGSSGTMK XX SC SwissProt #P24488 XX FT 15 74 basic region FT 101 137 serine-/threonine-rich region XX IN T00350; HAP3; yeast, Saccharomyces cerevisiae. IN T00351; HAP4; yeast, Saccharomyces cerevisiae. IN T01263; HAP3; fission yeast, Schizosaccharomyces pombe. XX BS R00262; Y$CYC1_09; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: M63639; SPPHP2(g). DR SwissProt: P24488; PHP2_SCHPO. DR PIR: A39605; A39605. XX RN [1] RA Xing Y., Fikes J. D., Guarente L. RT Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain RL EMBO J. 12:4647-4655 (1993). RN [2] RA Olesen J. T., Fikes J. D., Guarente L. RT The Schizosaccharomyces pombe homolog of Saccharomyces RT cerevisiae HAP2 reveals selective and stringent conservation RT of the small essential core protein domain RL Mol. Cell. Biol. 11:611-619 (1991). XX // AC T00349 XX ID T00349 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA HAP2 XX SY CBF-B (rat); CP1B (human, rat); NF-YA (mouse); XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 1.6.1.0.2. XX SZ 265 AA; 29.8 kDa (gene) XX SQ MSADETDAKFHPLETDLQSDTAAATSTAAASRSPSLQEKPIEMPLDMGKAPSPRGEDQRV SQ TNEEDLFLFNRLRASQNRVMDSLEPQQQSQYTSSSVSTMEPSADFTSFSAVTTLPPPPHQ SQ QQQQQQQQQQQQQLVVQAQYTQNQPNLQSDVLGTAIAEQPFYVNAKQYYRILKRRYARAK SQ LEEKLRISRERKPYLHESRHKHAMRRPRGEGGRFLTAAEIKAMKSKKSGASDDPDDSHED SQ KKITTKIIQEQPHATSTAAAADKKT XX SC SwissProt #P06774 XX FT 1 153 transcription augmenting region FT 126 139 glutamine rich region FT 158 214 homologous to animal CP1B FT 162 178 subunit assembly domain (SAD) FT 194 214 DNA-binding domain FT 170 208 basic region XX SF glutamine-rich region XX FF activator of components of the mitochondrial electron transport chain XX IN T00087; CBF-A; rat, Rattus norvegicus. IN T00154; CP1A; human, Homo sapiens. IN T00350; HAP3; yeast, Saccharomyces cerevisiae. IN T00351; HAP4; yeast, Saccharomyces cerevisiae. IN T00616; NF-YB; mouse, Mus musculus. IN T01263; HAP3; fission yeast, Schizosaccharomyces pombe. XX BS R00989; AD$MLP_04; Quality: 6; adenovirus BS R02869; AS$HAP23_01; Quality: 6 BS R00262; Y$CYC1_09; Quality: 2; yeast, Saccharomyces cerevisiae BS R00263; Y$CYC1_10; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: M15243; SCHAP2(g). DR SwissProt: P06774; HAP2_YEAST. DR PIR: A26771; A26771. XX RN [1] RA Pinkham J. L., Olesen J. T., Guarente L. P. RT Sequence and Nuclear Localization of the Saccharomyces RT cerevisiae HAP2 Protein, a Transcriptional Activator RL Mol. Cell. Biol. 7:578-585 (1987). RN [2] RA Olesen J., Hahn S., Guarente L. RT Yeast HAP2 and HAP3 Activators Both Bind to the CYC1 RT Upstream Activation Site, UAS2, in an Interdependent Manner RL Cell 51:953-961 (1987). RN [3] RA Olesen J. T., Guarente L. RT The HAP2 subunit of yeast CCAAT transcriptional activator RT contains adjacent domains for subunit association RT and DNA recognition: model for the HAP2/3/4 complex RL Genes Dev. 4:1714-1729 (1990). RN [4] RA Hahn S., Guarente L. RT Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex RL Science 240:314-321 (1988). XX // AC T00350 XX ID T00350 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA HAP3 XX SY CBF-A (rat); CP1a (human, rat); NF-YB (mouse); XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 1.6.1.0.1. XX SZ 144 AA; 16 kDa (gene) XX SQ MNTNESEHVSTSPEDTQENGGNASSSGSLQQISTLREQDRWLPINNVARLMKNTLPPSAK SQ VSKDAKECMQECVSELISFVTSEASDRCAADKRKTINGEDILISLHALGFENYAEVLKIY SQ LAKYRQQQALKNQLMYEQDDEEVP XX SC SwissProt #P13434 XX FT 5 18 acidic region FT 36 125 homologous to animal CP1A FT 42 52 DNA-binding domain FT 137 142 acidic region XX SF highly conserved between S.c., S.pombe, rat, mouse, human XX IN T00088; CBF-B; rat, Rattus norvegicus. IN T00157; CP1B; human, Homo sapiens. IN T00347; HAP2; human, Homo sapiens. IN T00348; HAP2; fission yeast, Schizosaccharomyces pombe. IN T00349; HAP2; yeast, Saccharomyces cerevisiae. IN T00351; HAP4; yeast, Saccharomyces cerevisiae. IN T00615; NF-YA; mouse, Mus musculus. XX BS R00990; AD$MLP_05; Quality: 6; adenovirus BS R02869; AS$HAP23_01; Quality: 6 BS R00262; Y$CYC1_09; Quality: 2; yeast, Saccharomyces cerevisiae BS R00264; Y$CYC1_11; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: M20318; SCHAP(g). DR SwissProt: P13434; HAP3_YEAST. DR PIR: A28123; A28123. XX RN [1] RA Olesen J., Hahn S., Guarente L. RT Yeast HAP2 and HAP3 Activators Both Bind to the CYC1 RT Upstream Activation Site, UAS2, in an Interdependent Manner RL Cell 51:953-961 (1987). RN [2] RA Olesen J. T., Guarente L. RT The HAP2 subunit of yeast CCAAT transcriptional activator RT contains adjacent domains for subunit association RT and DNA recognition: model for the HAP2/3/4 complex RL Genes Dev. 4:1714-1729 (1990). RN [3] RA Hahn S., Guarente L. RT Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex RL Science 240:314-321 (1988). RN [4] RA Hahn S., Pinkham J., Wei R., Miller R., Guarente L. RT The HAP3 regulatory locus of Saccharomyces cerevisiae RT encodes divergent overlapping transcripts RL Mol. Cell. Biol. 8:655-663 (1988). XX // AC T00351 XX ID T00351 XX DT 26.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA HAP4 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 554 AA; 62 kDa (gene) XX SQ MTAKTFLLQASASRPRSNHFKNEHNNIPLAPVPIAPNTNHHNNSSLEFENDGSKKKKKSS SQ LVVRTSKHWVLPPRPRPGRRSSSHNTLPANNTNNILNVGPNSRNSSNNNNNNNIISNRKQ SQ ASKEKRKIPRHIQTIDEKLINDSNYLAFLKFDDLENEKFHSSASSISSPSYSSPSFSSYR SQ NRKKSEFMDDESCTDVETIAAHNSLLTKNHHIDSSSNVHAPPTKKSKLNDFDLLSLSSTS SQ SSATPVPQLTKDLNMNLNFHKIPHKASFPDSPADFSPADSVSLIRNHSLPTNLQVKDKIE SQ DLNEIKFFNDFEKLEFFNKYAKVNTNNDVNENNDLWNSYLQSMDDTTGKNSGNYQQVDND SQ DNMSLLNLPILEETVSSGQDDKVEPDEEDIWNYLPSSSSQQEDSSRALKKNTNSEKANIQ SQ AKNDETYLFLQDQDESADSHHHDELGSEITLADNKFSYLPPTLEELMEEQDCNNGRSFKN SQ FMFSNDTGIDGSAGTDDDYTKVLKSKKISTSKSNANLYDLNDNNNDATATNELDQSSFID SQ DLDEDVDFLKVQVF XX SC SwissProt #P14064 XX SF acidic region XX FF contributes transcription activation domain to the HAP2/3/4 complex XX IN T00087; CBF-A; rat, Rattus norvegicus. IN T00088; CBF-B; rat, Rattus norvegicus. IN T00154; CP1A; human, Homo sapiens. IN T00157; CP1B; human, Homo sapiens. IN T00347; HAP2; human, Homo sapiens. IN T00348; HAP2; fission yeast, Schizosaccharomyces pombe. IN T00349; HAP2; yeast, Saccharomyces cerevisiae. IN T00350; HAP3; yeast, Saccharomyces cerevisiae. IN T00615; NF-YA; mouse, Mus musculus. IN T00616; NF-YB; mouse, Mus musculus. IN T01263; HAP3; fission yeast, Schizosaccharomyces pombe. XX BS R02869; AS$HAP23_01; Quality: 6 XX DR EMBL: X16727; SCHAP4(g). DR SwissProt: P14064; HAP4_YEAST. DR PIR: A32984; A32984. XX RN [1] RA Olesen J. T., Guarente L. RT The HAP2 subunit of yeast CCAAT transcriptional activator RT contains adjacent domains for subunit association RT and DNA recognition: model for the HAP2/3/4 complex RL Genes Dev. 4:1714-1729 (1990). RN [2] RA Forsburg S. L., Guarente L. RT Identification and characterization of HAP4: a third RT component of the CCAAT-bound HAP2/HAP3 heteromer RL Genes Dev. 3:1166-1178 (1989). XX // AC T00352 XX ID T00352 XX DT 23.11.92 (created); ewi. XX FA H2B abp 1 XX OS sea urchin, Lytechinus pictus OC eukaryota; animalia; eumetazoa; echinodermata; echinozoa; OC echinoidea; echinacea; temnopleuroida; toxopneustidae XX CP mid-blastula XX FF stage-specific activator XX BS R02455; SP$H2BL1_01; Quality: 6; sea urchin, Strongylocentrotus purpuratus XX RN [1] RA Zhao A. Z., Colin A. M., Bell J., Baker M., Char B. R., Maxson R. RT Activation of a late H2B histone gene in blastula-stage RT sea urchin embryos by an unusual enhancer element located 3' of the gene RL Mol. Cell. Biol. 10:6730-6741 (1990). XX // AC T00353 XX ID T00353 XX DT 12.03.93 (created); ewi. XX FA HBLF XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (liver) XX RN [1] RA Trujillo M. A., Letovsky J., Maguire H. F., Lopez-Cabrera M., Siddiqui A. RT Functional analysis of a liver-specific enhancer of the hepatitis B virus RL Proc. Natl. Acad. Sci. USA 88:3797-3801 (1991). XX // AC T00354 XX ID T00354 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA HBP-1 XX SY HBP-1a; HBP-1b; XX OS wheat, Triticum aestivum OC eukaryota; plantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX CL C0008; bZIP; . XX SF 2 families of isoforms: HBP-1a and HBP-1b XX IN T01394; HBP-1a(1); wheat, Triticum aestivum. IN T01395; HBP-1a(c14); wheat, Triticum aestivum. XX BS R01914; CAMV$35SR_02; Quality: 6; CaMV, cauliflower mosaic virus BS R01915; CAMV$35SR_03; Quality: 6; CaMV, cauliflower mosaic virus BS R01609; TDNA$NOS_02; Quality: 6; Agrobacterium tumefaciens XX DR EMBL: X56781; TA1A17(r). DR EMBL: X56782; TA1B38(r). DR EMBL: M28704; TAHBP1A(r). DR SwissProt: P23922; HBPA_WHEAT. DR SwissProt: P23923; HBPB_WHEAT. DR PIR: A41349; A41349. DR PIR: S15346; S15346. DR PIR: S15347; S15347. XX RN [1] RA Mikami K., Sakamoto A., Iwabuchi M. RT The HBP-1 family of wheat basic/leucine zipper proteins RT interacts with overlapping cis-acting hexamer motifs of plant histone genes RL J. Biol. Chem. 269:9974-9985 (1994). RN [2] RA Mikami K., Sakamoto A., Takase H., Tabata T., Iwabuchi M. RT Wheat nuclear protein HBP-1 binds to the hexameric RT sequence in the promoter of various plant genes RL Nucleic Acids Res. 17:9707- (1989). RN [3] RA Tabata T., Nakayama T., Mikami K., Iwabuchi M. RT HBP-1a and HBP-1b: leucine zipper-type transcription factors of wheat RL EMBO J. 10:1459-1467 (1991). XX // AC T00355 XX ID T00355 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA heat-induced factor XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO HSTF XX RN [1] RA Kingston R. E., Schuetz T. J., Larin Z. RT Heat-Inducible Human Factor That Binds to a Human hsp70 Promoter RL Mol. Cell. Biol. 7:1530-1534 (1987). XX // AC T00356 XX ID T00356 XX DT 14.12.92 (created); ewi. XX FA HEF-1B XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP non-lymphoid cells XX BS R02698; HT1$HTLV1_10; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R02699; HT1$HTLV1_11; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R02701; HT1$HTLV1_13; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I XX RN [1] RA Nyborg J. K., Dynan W. S. RT Interaction of Cellular Proteins with the Human T-cell RT Leukemia Virus Type I Transcriptional Control Region RL J. Biol. Chem. 265:8230-8236 (1990). XX // AC T00357 XX ID T00357 XX DT 14.12.92 (created); ewi. XX FA HEF-4C XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX FF different from NF-1 XX BS R02706; HT1$HTLV1_18; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I XX RN [1] RA Nyborg J. K., Matthews M.-A. H., Yucel J., Walls L., RA Golde W. T., Dynan W. S., Wachsman W. RT Interaction of Host Cell Proteins with the Human T-cell RT Leukemia Virus Type I Transcriptional Control Region RL J. Biol. Chem. 265:8237-8242 (1990). XX // AC T00358 XX ID T00358 XX DT 14.12.92 (created); ewi. XX FA HEF-1T XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 41+59 kDa (SDS) XX CP T-lymphocytes XX BS R02697; HT1$HTLV1_09; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R02700; HT1$HTLV1_12; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R02703; HT1$HTLV1_15; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I XX RN [1] RA Nyborg J. K., Dynan W. S. RT Interaction of Cellular Proteins with the Human T-cell RT Leukemia Virus Type I Transcriptional Control Region RL J. Biol. Chem. 265:8230-8236 (1990). XX // AC T00359 XX ID T00359 XX DT 15.10.92 (created); ewi. XX FA alphaH2-alphaH3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ <64 kDa XX CP (HeLa) XX BS R00812; HSV1$IE2_01; Quality: 6; HSV-1, herpes simplex virus type 1 XX RN [1] RA Kristie T. M., Roizman B. RT Host cell proteins bind to the cis-acting site required RT for virion-mediated induction of herpes simplex virus 1 alpha genes RL Proc. Natl. Acad. Sci. USA 84:71-75 (1987). RN [2] RA McKnight J. L. C., Kristie T. M., Roizman B. RT Binding of the virion protein mediating alpha gene RT induction in herpes simplex virus 1-infected cells RT to its cis site requires cellular proteins RL Proc. Natl. Acad. Sci. USA 84:7061-7065 (1987). XX // AC T00360 XX ID T00360 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA HiNF-A XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO H4TF-1 XX CP (HeLa) XX BS R02171; HINFA$CONS; Quality: 6 BS R00658; HS$HH1_01; Quality: 6; human, Homo sapiens BS R00682; HS$HH4_03; Quality: 6; human, Homo sapiens BS R00683; HS$HH4_04; Quality: 6; human, Homo sapiens BS R00686; HS$HH4_07; Quality: 6; human, Homo sapiens XX RN [1] RA van Wijnen A. J., Wright K. L., Massung R. F., Gerretsen RA M., Stein J. L., Stein G. S. RT Two target sites for protein binding in the promoter RT region of a cell cycle regulated human H1 histone gene RL Nucleic Acids Res. 16:571-592 (1988). RN [2] RA Stein G., Lian J., Stein J., Briggs R., Shalhoub V., RA Wright K., Pauli U., van Wijnen A. RT Altered binding of human histone gene transcription RT factors during the shutdown of proliferation and onset RT of differentiation in HL-60 cells RL Proc. Natl. Acad. Sci. USA 86:1865-1869 (1989). RN [3] RA Pauli U., Chrysogelos S., Stein G., Stein J., Nick H. RT Protein-DNA Interactions in Vivo Upstream of a Cell RT Cycle-Regulated Human H4 Histone Gene RL Science 236:1308-1311 (1987). RN [4] RA van Wijnen A. J., Stein J. L., Stein G. S. RT A nuclear protein with affinity for the 5' flanking RT region of a cell cycle dependent human H4 histone gene in vitro RL Nucleic Acids Res. 15:1679-1698 (1987). XX // AC T00361 XX ID T00361 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA HiNF-B XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO H1TF1 XX BS R00659; HS$HH1_02; Quality: 6; human, Homo sapiens XX RN [1] RA van Wijnen A. J., Wright K. L., Massung R. F., Gerretsen RA M., Stein J. L., Stein G. S. RT Two target sites for protein binding in the promoter RT region of a cell cycle regulated human H1 histone gene RL Nucleic Acids Res. 16:571-592 (1988). RN [2] RA van Wijnen A. J., Massung R. F., Stein J. L., Stein G. S. RT Human H1 Histone Gene Promoter CCAAT Box Binding Protein RT HiNF-B Is a Mosaic Factor RL Biochemistry 27:6534-6541 (1988). XX // AC T00362 XX ID T00362 XX DT 15.10.92 (created); ewi. XX FA HiNF-C XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00683; HS$HH4_04; Quality: 6; human, Homo sapiens BS R00684; HS$HH4_05; Quality: 6; human, Homo sapiens BS R00685; HS$HH4_06; Quality: 6; human, Homo sapiens XX RN [1] RA Stein G., Lian J., Stein J., Briggs R., Shalhoub V., RA Wright K., Pauli U., van Wijnen A. RT Altered binding of human histone gene transcription RT factors during the shutdown of proliferation and onset RT of differentiation in HL-60 cells RL Proc. Natl. Acad. Sci. USA 86:1865-1869 (1989). XX // AC T00363 XX ID T00363 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA HiNF-D XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO HiNF-D3 XX BS R00687; HS$HH4_08; Quality: 2; human, Homo sapiens BS R00688; HS$HH4_09; Quality: 6; human, Homo sapiens XX RN [1] RA Stein G., Lian J., Stein J., Briggs R., Shalhoub V., RA Wright K., Pauli U., van Wijnen A. RT Altered binding of human histone gene transcription RT factors during the shutdown of proliferation and onset RT of differentiation in HL-60 cells RL Proc. Natl. Acad. Sci. USA 86:1865-1869 (1989). RN [2] RA van Wunen A. J., Choi T. K., Owen T. A., Wright K. RA L., Lian J. B., Jaenisch R., Stein J. L., Stein G. S. RT Involvement of the cell cycle-regulated nuclear factor RT HiNF-D in cell growth control of a human H4 histone RT gene during hepatic development in transgenic mice RL Proc. Natl. Acad. Sci. USA 88:2573-2577 (1991). XX // AC T00364 XX ID T00364 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA HiNF-D3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO HiNF-D XX BS R00673; HS$H3_02; Quality: 6; human, Homo sapiens XX RN [1] RA Stein G., Lian J., Stein J., Briggs R., Shalhoub V., RA Wright K., Pauli U., van Wijnen A. RT Altered binding of human histone gene transcription RT factors during the shutdown of proliferation and onset RT of differentiation in HL-60 cells RL Proc. Natl. Acad. Sci. USA 86:1865-1869 (1989). XX // AC T00365 XX ID T00365 XX DT 12.03.93 (created); ewi. XX FA HiNF-M XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP adult liver, spleen, (thymus); fetal liver, brain XX BS R00687; HS$HH4_08; Quality: 2; human, Homo sapiens XX RN [1] RA van Wunen A. J., Choi T. K., Owen T. A., Wright K. RA L., Lian J. B., Jaenisch R., Stein J. L., Stein G. S. RT Involvement of the cell cycle-regulated nuclear factor RT HiNF-D in cell growth control of a human H4 histone RT gene during hepatic development in transgenic mice RL Proc. Natl. Acad. Sci. USA 88:2573-2577 (1991). XX // AC T00366 XX ID T00366 XX DT 15.10.92 (created); ewi. DT 07.06.95 (updated); ewi. XX FA HIP1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 180 kDa (SDS) XX FF binds to an element that is essential for transcriptional FF increase of the DHFR gene at the G1/S phase boundary; FF free and bound protein exchange rapidly XX BS R02172; HIP1$CONS; Quality: 6 BS R00283; MOUSE$DHFR_03; Quality: 6; mouse, Mus musculus BS R01928; MOUSE$DHFR_08; Quality: 2; mouse, Mus musculus BS R01929; SV$SV40_58; Quality: 6; SV40, simian virus 40 XX RN [1] RA Means A. L., Slansky J. E., McMahon S. L., Knuth M. W., Farnham P. J. RT The HIP1 binding site is required for growth regulation RT of the dihydrofolate reductase gene promoter RL Mol. Cell. Biol. 12:1054-1063 (1992). RN [2] RA Means A. L., Farnham P. G. RT Transcription Initiation from the Dihydrofolate Reductase RT Promoter Is Positioned by HIP1 Binding at the Initiation Site RL Mol. Cell. Biol. 10:653-661 (1990). RN [3] RA Blake M. C., Jambou R. C., Swick A. G., Kahn J. W., Azizkhan J. C. RT Transcriptional initiation is controlled by upstream RT GC-box interactions in a TATAA-less promoter RL Mol. Cell. Biol. 10:6632-6641 (1990). XX // AC T00367 XX ID T00367 XX DT 22.10.92 (created); ewi. DT 14.05.96 (updated); ewi. XX FA Id3 XX SY HLH462; inhibitor of DNA-binding 3; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0011; HLH; 1.2.8.0.4. XX SZ 119 AA; 13.1 kDa (cDNA) XX SQ MKALSPVRGCYEAVCCLSERSLAIARGRGKSPSTEEPLSLLDDMNHCYSRLRELVPGVPR SQ GTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISKDKRSFCH XX SC SwissProt #P41133 XX FT 41 81 helix-loop-helix domain XX SF no basic (=DNA-binding) domain XX CP lung, intestine, brain, thymus; less in muscle, spleen, CP liver; very low in heart [3]; ubiquitous [1]; CN testis [3]; XX FF inhibits DNA-binding of MyoD/E12 [3]; FF involved in growth induction by serum growth factors [2]; XX DR EMBL: M60523; MMHLH462(r). DR EMBL: M60524; MMHLH462P(g). DR SwissProt: P41133; ID3_MOUSE. DR PIR: A39114; A39114. XX RN [1] RA Riechmann V., van Cruechten I., Sablitzky F. RT The expression pattern of Id4, a novel dominant negative RT helix-loop-helix protein, is distinct from Id1, Id2 and Id3 RL Nucleic Acids Res. 22:749-755 (1994). RN [2] RA Barone M. V., Pepperkok R., Peverali F. A., Philipson L. RT Id proteins control growth induction in mammalian cells RL Proc. Natl. Acad. Sci. USA 91:4985-4988 (1994). RN [3] RA Christy B. A., Sanders L. K., Lau L. F., Copeland RA N. G., Jenkins N. A., Nathans D. RT An Id-related helix-loop-helix protein encoded by RT a growth factor-inducible gene RL Proc. Natl. Acad. Sci. USA 88:1815-1819 (1991). XX // AC T00368 XX ID T00368 XX DT 15.10.92 (created); ewi. DT 19.11.96 (updated); ewi. XX FA HNF-1A XX SY APF; HNF-1; HNF-1alpha; HNF1; LF-B1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; 3.1.1.12.1.1. XX SZ 631 AA; 67.3 kDa (cDNA), 92 kDa (SDS) XX SQ MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAEL SQ PNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVK SQ SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA SQ GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAE SQ CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALP SQ AHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSH SQ SLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPA SQ SLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPV SQ QSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTK SQ QVFTSDTEASSESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQS SQ SDSSNGQSHLLPSNHSVIETFISTQMASSSQ XX SC SwissProt #P20823, Tyr-322 taken from Ref. [3478] XX FT 1 31 dimerization domain (by similarity) FT 161 186 POUs A subdomain homolog FT 199 279 homeo domain FT 208 219 helix 1 [3]; FT 226 240 helix 2 [3]; FT 261 274 helix 3 [3]; FT 289 314 proline-rich region (10/26) FT 438 631 replaced by 438-494 in HNF-1C [4]; FT 501 631 replaced by 501-542 in HNF-1B [4]; FT 583 627 serine-/threonine-rich region (19/45) XX SF usage of an alternative poly(A) signal leads to HNF-1B, SF whereas an unspliced intron introduces a new stop SF codon giving rise to HNF-1C [4]; XX CP liver, intestine, spleen, stomach, kidney XX FF activator [4]; XX IN T00889; vHNF-1; rat, Rattus norvegicus. IN T00890; vHNF-1; mouse, Mus musculus. IN T01950; HNF-1B; human, Homo sapiens. IN T01951; HNF-1C; human, Homo sapiens. XX MX M00132; V$HNF1_01 MX M00206; V$HNF1_C XX BS R01913; HBV$SA_02; Quality: 3; HBV, human hepatitis B virus BS R01807; HBV$SP_01; Quality: 4; HBV, human hepatitis B virus BS R02174; HNF1$CONS; Quality: 6 BS R00077; HS$ALBU_01; Quality: 1; human, Homo sapiens BS R03260; HS$APOA2_15; Quality: 1; human, Homo sapiens BS R03666; HS$APOB_15; Quality: 1; human, Homo sapiens BS R00237; HS$CRP_01; Quality: 4; human, Homo sapiens BS R00238; HS$CRP_02; Quality: 4; human, Homo sapiens BS R03302; HS$GP2B_09; Quality: 4; human, Homo sapiens BS R03305; HS$GP2B_12; Quality: 4; human, Homo sapiens BS R02910; HS$IGFBP1_01; Quality: 1; human, Homo sapiens BS R02970; MOUSE$ALBU_20; Quality: 2; mouse, Mus musculus BS R01625; RAT$A1I3_03; Quality: 5; rat, Rattus norvegicus BS R00431; RAT$AFEP_08; Quality: 4; rat, Rattus rattus XX DR EMBL: M57732; HSHNF1(r). DR SwissProt: P20823; HNFA_HUMAN. DR PIR: A36749; A36749. DR Compel: C00045 DR Compel: C00048 DR Compel: C00051 DR Compel: C00095 XX RN [1] RA Monaci P., Nicosia A., Cortese R. RT Two different liver-specific factors stimulate in RT vitro transcription from the human alpha1-antitrypsin promoter RL EMBO J. 7:2075-2087 (1988). RN [2] RA Feuerman M. H., Godbout R., Ingram R. S., Tilghman S. M. RT Tissue-Specific Transcription of the Mouse alpha-Fetoprotein RT Gene Promoter Is Dependent of HNF-1 RL Mol. Cell. Biol. 9:4204-4212 (1989). RN [3] RA Leiting B., De Francesco R., Tomei L., Cortese R., Otting G., Whthrich K. RT The three-dimensional NMR-solution structure of the RT polypeptide fragment 195-286 of the LFB1/HNF1 transcription RT factor from rat liver comprises a non-classical homeodomain RL EMBO J. 12:1797-1803 (1993). RN [4] RA Bach I., Yaniv M. RT More potent transcriptional activators or a transdominant RT inhibitor of the HNF1 homeoprotein family are generated RT by alternative RNA processing RL EMBO J. 12:4229-4242 (1993). RN [5] RA Williams T., Admon A., Luescher B., Tjian R. RT Cloning and expression of AP-2, a cell-type-specific RT transcription factor that activates inducible enhancer elements RL Genes Dev. 2:1557-1569 (1988). XX // AC T00369 XX ID T00369 XX DT 15.10.92 (created); ewi. DT 19.11.96 (updated); ewi. XX FA HNF-1 XX SY APF; HNF-1alpha; HNF1; LF-B1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.1.12.1.1. XX SZ 628 AA; 67.2 kDa (cDNA), 88 kDa (SDS) [27], 92-98 SZ kDa (SDS) [3], 90 kDa (GF) [3]; XX SQ MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGDGPLDKGESCGGTRGDLTEL SQ PNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVK SQ SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA SQ GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAE SQ CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALP SQ AHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSS SQ LLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPAS SQ LGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQ SQ SHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQV SQ FTSDTEASSEPGLHEPSSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSD SQ SNGHSHLLPSNHGVIETFISTQMASSSQ XX SC SwissProt #P15257 XX FT 1 31 dimerization domain [7]; FT 161 186 POUs A subdomain homolog FT 199 279 homeo domain FT 208 219 helix 1 [16]; FT 226 240 helix 2 [16]; FT 261 274 helix 3 [16]; FT 281 318 activation domain II (ADII) FT 546 627 activation domain I (ADI) FT 289 314 proline-rich region (10/26) FT 583 627 serine-/threonine-rich region (19/45) XX SF tripartite DNA-binding domain comprising the POUs SF homology region extended towards the N-terminus (pos. SF 113), the homeo domain, and the dimerization domain [7]; SF dimerization domain comprises a kinked alpha helix SF (7-18 and 23-32), both helices in a parallel orientation SF within the dimer [7], [10]; SF dimerization constant > 10E+8/mol [11]; SF instead of the usual 3 AA, there is a long loop of SF 21 residues between helices 2 and 3, which both are SF encoded by different exons [12]; SF of the homeo domain, helix 3 contacts the major groove SF of the DNA, the loop is irregularly folded, and helix SF 2 is extended by one extra helical turn [15], [16]; SF dimer docking to the DNA requires either bending of SF the DNA or rearrangement of the peptide monomers within the dimer [15]; SF the homeo domain is sufficient for monomeric DNA-binding, SF the POUs is auxiliary in mediating full affinity and specificity [14]; SF may be glycosylated SF a similar factor in lung has 110 + 120 kDa (SDS) XX CP liver, intestine, spleen, stomach, kidney [27]; CN brain, heart, lung, skin, thymus [27], spleen [1]; XX FF activator [3], [32]; FF may act synergistically when bound to two distant sites [32]; FF involved in hepatocyte-specific gene expression, although FF not being the sole determinant [27], [1]; FF cooperates with other liver-enriched factors such FF as C/EBP, HNF-3, HNF-4 [1]; FF expressed in hepatocytes only after differentiation, FF its gene being regulated by other liver-enriched factors FF such as HNF-4 [31], [2], [13]; FF down-regulates its own expression by an indirect mechanism, FF but dependent on an intact NF-1 DNA-binding domain FF an a C-terminal region different from ADI [19]; FF dimerization is facilitated by cofactor DCoH, two FF molecules of which interact with an HNF-1 dimer thus FF stabilizing it and augmenting transcription activation [9]; FF HNF-1 activity may be modulated by HNF-1beta (vHNF-1) [17]; XX IN T00889; vHNF-1; rat, Rattus norvegicus. IN T00890; vHNF-1; mouse, Mus musculus. XX MX M00132; V$HNF1_01 MX M00206; V$HNF1_C XX BS R02174; HNF1$CONS; Quality: 6 BS R00118; HS$A1ANTR_05; Quality: 3; human, Homo sapiens BS R00120; HS$A1ANTR_07; Quality: 4; human, Homo sapiens BS R00121; HS$A1ANTR_08; Quality: 4; human, Homo sapiens BS R00123; HS$A1ANTR_10; Quality: 4; human, Homo sapiens BS R00077; HS$ALBU_01; Quality: 1; human, Homo sapiens BS R00081; HS$ALBU_05; Quality: 4; human, Homo sapiens BS R03253; HS$APOA2_08; Quality: 1; human, Homo sapiens BS R03260; HS$APOA2_15; Quality: 1; human, Homo sapiens BS R04122; HS$PTHRO_01; Quality: 5; human, Homo sapiens BS R04123; HS$PTHRO_02; Quality: 5; human, Homo sapiens BS R02045; MOUSE$AFEP_14; Quality: 5; mouse, Mus musculus BS R00091; MOUSE$ALBU_10; Quality: 4; mouse, Mus musculus BS R00432; RAT$AFEP_09; Quality: 4; rat, Rattus rattus BS R00436; RAT$AF_01; Quality: 4; rat, Rattus norvegicus BS R00099; RAT$ALBU_23; Quality: 3; rat, Rattus norvegicus BS R01800; RAT$ALDB_03; Quality: 4; rat, Rattus norvegicus BS R00439; RAT$BF_03; Quality: 2; rat, Rattus norvegicus BS R02780; RAT$CY2E1_01; Quality: 4; rat, Rattus norvegicus BS R02895; XENLA$VITA2_03; Quality: 4; clawed frog, Xenopus laevis XX DR EMBL: X54423; RNHNF1(r). DR EMBL: X53297; RNHNF1POU(r). DR EMBL: J03170; RNLFB1A(r). DR EMBL: X67649; RNLFHNPR(g). DR EMBL: X63959; RRHNF1(g). DR SwissProt: P15257; HNFA_RAT. DR PIR: A33333; A33333. DR PIR: A34590; A34590. DR PIR: A39262; A39262. DR PIR: S11568; S11568. DR PIR: S25485; S25485. DR Compel: C00041 DR PDB: 1lfb; TRANSCRIPTION FACTOR LFB1 (HOMEODOMAIN) RATTUS RATTUS. XX RN [1] RA Xanthopoulos K. G., Prezioso V. R., Chen W. S., Sladek RA F. M., Cortese R., Darnell Jr. J. E. RT The different tissue trancription patterns of genes RT for HNF-1, C/EBP, HNF-3 and HNF-4, protein factors RT that govern liver-specific transcription RL Proc. Natl. Acad. Sci. USA 88:3807-3811 (1991). RN [2] RA Tian J.-M., Schibler U. RT Tissue-specific expression of the gene encoding hepatocyte RT nuclear factor 1 may involve hepatocyte nuclear factor 4 RL Genes Dev. 5:2225-2234 (1991). RN [3] RA Frain M., Swart G., Monaci P., Nicosia A., Staempfli RA S., Frank R., Cortese R. RT The liver-specific transcription factor LF-B1 contains RT a highly diverged homeobox DNA binding domain RL Cell 59:145-157 (1989). RN [4] RA Hardon E. M., Frain M., Paonessa G., Cortese R. RT Two distinct factors interact with the promoter regions RT of several liver-specific genes RL EMBO J. 7:1711-1719 (1988). RN [5] RA Li Y., Shen R.-F., Tsai S. Y., Woo S. L. C. RT Multiple Hepatic trans-Acting Factors Are Required RT for In Vitro Transcription of the Human Alpha-1-Antitrypsin Gene RL Mol. Cell. Biol. 8:4362-4369 (1988). RN [6] RA Abraham L. J., Bradshaw A. D., Shiels B. R., Northemann RA W., Hudson G., Fey G. H. RT Hepatic Transcription of the Acute-Phase alpha1-Inhibitor RT III Gene Is Controlled by a Novel Combination of cis-Acting RT Regulatory Elements RL Mol. Cell. Biol. 10:3483-3491 (1990). RN [7] RA Nicosia A., Monaci P., Tomei L., De Francesco R., RA Nuzzo M., Stunnenberg H., Cortese R. RT A myosin-like dimerization helix and an extra-large RT homeodomain are essential elements of the tripartite RT DNA binding structure of LFB1 RL Cell 61:1225-1236 (1990). RN [8] RA Courtois G., Baumhueter S., Crabtree G. R. RT Purified hepatocyte nuclear factor 1 interacts with RT a family of hepatocyte-specific promoters RL Proc. Natl. Acad. Sci. USA 85:7937-7941 (1988). RN [9] RA Mendel D. B., Khavari P. A., Conley P. B., Graves RA M. K., Hansen L. P., Admon A., Crabtree G. R. RT Characterization of a cofactor that regulates dimerization RT of a mammalian homeodomain protein RL Science 254:1762-1767 (1991). RN [10] RA Pastore A., De Francesco R., Barbato G., Morelli , RA Castiglione M. A., Motta A., Cortese R. RT 1H Resonance assigment and secondary structure determination RT of the dimerization domain of transcription factor LFB1 RL Biochemistry 30:148-153 (1991). RN [11] RA De Francesco R., Pastore A., Vecchio G., Cortese R. RT Circular dichroism study on the conformational stability RT of the dimerization domain of transcription factor LFB1 RL Biochemistry 30:143-147 (1991). RN [12] RA Bach I., Pontoglio M., Yaniv M. RT Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1) RL Nucleic Acids Res. 20:4199-4204 (1992). RN [13] RA Kuo C. J., Conley P. B., Chen L., Sladek F. M., Darnell RA J. E., Crabtree G. R. RT A transcriptional hierarchy involved in mammalian cell-type specification RL Nature 355:457-461 (1992). RN [14] RA Tomei L., Cortese R., De Francesco R. RT A POU-A related region dictates DNA binding specificity RT of LFB1/HNF1 by orienting the two XL-homeodomains in the dimer RL EMBO J. 11:4119-4129 (1992). RN [15] RA Ceska T. A., Lamers M., Monaci P., Nicosia A., Cortese R., Suck D. RT The X-ray structure of an atypical homeodomain present RT in the rat liver transcription factorLFB1/HNF1 and RT implications for DNA binding RL EMBO J. 12:1805-1810 (1993). RN [16] RA Leiting B., De Francesco R., Tomei L., Cortese R., Otting G., Whthrich K. RT The three-dimensional NMR-solution structure of the RT polypeptide fragment 195-286 of the LFB1/HNF1 transcription RT factor from rat liver comprises a non-classical homeodomain RL EMBO J. 12:1797-1803 (1993). RN [17] RA Babajko S., Tronch J. F., Groyer A. RT Liver-specific expression of human insulin-like growth RT factor binding protein 1: Functional role of transcription RT factor HNF1 in vivo RL Proc. Natl. Acad. Sci. USA 90:272-276 (1993). RN [18] RA Citron B. A., Davis M. D., Milstien S., Gutierrez RA J., Mendel D. B., Crabtree G. R., Kaufman S. RT Identity of 4a-carbinolamine dehydratase, a component RT of the phenylalanine hydroxylation system, and DCoH, RT a transregulator of homeodomain proteins RL Proc. Natl. Acad. Sci. USA 89:11891-11894 (1992). RN [19] RA Piaggio G., Tomei L., Toniatti C., De Francesco R., Gerstner J., Cortese R. RT LFB1/HNF1 acts as a repressor of its own transcription RL Nucleic Acids Res. 22:4284-4290 (1994). RN [20] RA Chouard T., Blumenfeld M., Bach I., Vandekerckhove RA J., Cereghini S., Yaniv M. RT A distal dimerization domain is essential for DNA-binding RT by the atypical HNF1 homeodomain RL Nucleic Acids Res. 18:5853-5863 (1990). RN [21] RA Finney M. RT The homeodomain of the transcription factor LF-B1 RT has a 21 amino acid loop between helix 2 and helix 3 RL Cell 60:5-6 (1990). RN [22] RA Tsutsumi K.-I., Ito K., Ishikawa K. RT Developmental Appearance of Transcription Factors RT That Regulate Liver-Specific Expression of the Aldolase B Gene RL Mol. Cell. Biol. 9:4923-4931 (1989). RN [23] RA Chang H.-K., Wang B.-Y., Yuh C.-H., Wei C.-L., Ting L.-P. RT A Liver-Specific Nuclear Factor Interacts with the RT Promoter Region of the Large Surface Protein Gene of Human Hepatitis B Virus RL Mol. Cell. Biol. 9:5189-5197 (1989). RN [24] RA Courtois G., Morgan J. G., Campbell L. A., Fourel G., Crabtree G. R. RT Interaction of a liver-specific nuclear factor with RT the fibrinogen and alpha1-antitrypsin promoters RL Science 238:688-692 (1987). RN [25] RA Jose-Estanyol M., Danan J.-L. RT A Liver-Specific Factor and Nuclear Factor I Bind RT to the Rat alpha-Fetoprotein Promoter RL J. Biol. Chem. 263:10865-10871 (1988). RN [26] RA Baumhueter S., Courtois G., Crabtree G. R. RT A variant nuclear protein in dedifferentiated hepatoma RT cells binds to the same functional sequences in the RT beta fibrinogen gene promoter as HNF-1 RL EMBO J. 7:2485-2493 (1988). RN [27] RA Baumhueter S., Mendel D. B., Conley P. B., Kuo C. RA J., Turk C., Graves M. K., Edwards C. A., Courtois G., Crabtree G. R. RT HNF-1 shares three sequence motifs with the POU domain RT proteins and is identical to LF-B1 and APF RL Genes Dev. 4:372-379 (1990). RN [28] RA Lichtsteiner S., Schibler U. RT A Glycosylated Liver-Specific Transcription Factor RT Stimulates Transcription of the Albumin Gene RL Cell 57:1179-1187 (1989). RN [29] RA Ueno T., Gonzalez F. J. RT Transcriptional control of the rat hepatic CYP2E1 gene RL Mol. Cell. Biol. 10:4495-4505 (1990). RN [30] RA Chambaz J., Cardot P., Pastier D., Zannis V. I., Cladaras C. RT Promoter elements and factors required for hepatic RT transcription of the human apoA-II gene RL J. Biol. Chem. 266:11676-11685 (1991). RN [31] RA Cereghini S., Yaniv M., Cortese R. RT Hepatocyte dedifferentiation and extinction is accompanied RT by a block in the synthesis of mRNA coding for the RT transcription factor HNF1/LFB1 RL EMBO J. 9:2257-2263 (1990). RN [32] RA Toniatti C., Demartis A., Monaci P., Nicosia A., Ciliberto G. RT Synergistic trans-activation of the human C-reactive RT protein promoter by transcription factor HNF-1 binding at two distinct sites RL EMBO J. 9:4467-4475 (1990). RN [33] RA De Simone V., De Magistratis L., Lazzaro D., Gerstner RA J., Monaci P., Nicosia A., Cortese R. RT LFB3, a heterodimer-forming homeoprotein of the LFB1 RT family, is expressed in specialized epithelia RL EMBO J. 10:1435-1443 (1991). XX // AC T00370 XX ID T00370 XX DT 12.03.93 (created); ewi. DT 15.03.94 (updated); hwi. XX FA HNF-3 XX SY HNF3; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0023; fork head; 3.3.2.0.3. XX CP (liver, kidney) XX BS R03666; HS$APOB_15; Quality: 2; human, Homo sapiens BS R02678; MOUSE$A1PI_05; Quality: 6; mouse, Mus musculus BS R02970; MOUSE$ALBU_20; Quality: 6; mouse, Mus musculus BS R01464; MOUSE$TTPA_04; Quality: 6; mouse, Mus musculus BS R03444; MOUSE$TTPA_07; Quality: 6; mouse, Mus musculus XX DR EMBL: X74937; MMHNF3B(r). DR EMBL: X74938; MMHNF3G(r). DR EMBL: X74936; MMMHNF3A(r). DR Compel: C00064 DR Compel: C00065 DR Compel: C00066 DR Compel: C00067 XX RN [1] RA Liu J.-K., DiPersio C. M., Zaret K. S. RT Extracellular signals that regulate liver transcription RT factors during hepatic differentiation in vitro RL Mol. Cell. Biol. 11:773-784 (1991). XX // AC T00371 XX ID T00371 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA HNF-3 XX SY HNF-3A; HNF-3alpha; HNF-5; HNF3; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0023; fork head; 3.3.2.0.1. XX SZ 466 AA; 48.8 kDa (cDNA), 50 kDa (SDS) XX SQ MLGTVKMEGHESNDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMT SQ PASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGAALSPGGMGSMGAQP SQ AASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLIT SQ MAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNACFVKVARSPDKPGK SQ GSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGSGGGGSKGVPENRKDPSGPVNPS SQ AESPIHRGVHGKASQLEGAPAPGPAASPQTLDHSGATATGGGSELKSPASSSAPPISSGP SQ GGWICTPLSPTWLAPHESQLHLKGAPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQY SQ SPYGATLPASLPLGGASVATRSPIEPSALEPAYYQGVYSRPVLNTS XX SC SwissProt #P23512 XX FT 91 152 fork head homology region A FT 124 288 DNA-binding domain FT 161 270 fork head domain, homology region B FT 392 397 hexapeptide HPFSIN, region C XX CP liver (intestine, lung) XX FF involved in liver-specific gene expression XX BS R02176; HNF3A$CONS; Quality: 6 BS R02180; HNF5$CONS; Quality: 6 BS R00086; MOUSE$ALBU_05; Quality: 6; mouse, Mus musculus BS R04324; MOUSE$HNF3B_02; Quality: 4; mouse, Mus musculus BS R01464; MOUSE$TTPA_04; Quality: 6; mouse, Mus musculus BS R03140; RAT$TAT_15; Quality: 4; rat, Rattus norvegicus BS R03142; RAT$TAT_17; Quality: 4; rat, Rattus norvegicus BS R03143; RAT$TAT_18; Quality: 4; rat, Rattus norvegicus BS R03144; RAT$TAT_19; Quality: 4; rat, Rattus norvegicus BS R03148; RAT$TAT_23; Quality: 4; rat, Rattus norvegicus BS R03150; RAT$TAT_25; Quality: 4; rat, Rattus norvegicus BS R02895; XENLA$VITA2_03; Quality: 6; clawed frog, Xenopus laevis XX DR EMBL: X55955; RNHNF3A(r). DR SwissProt: P23512; HN3A_RAT. DR PIR: A36674; A36674. XX RN [1] RA Weigel D., Jaeckle H. RT The fork head domain: a novel DNA binding motif of RT eukaryotic transcription factors? RL Cell 63:455-456 (1990). RN [2] RA Sladek F. M., Darnell J. E. RT Mechanisms of liver-specific gene expression RL Curr. Opin. Gen. Dev. 2:256-259 (1992). RN [3] RA Li C., Lai C., Sigman D. S., Gaynor R. B. RT Cloning of a cellular factor, interleukin binding RT factor, that binds to NFAT-like motifs in the human RT immunodeficiency virus long terminal repeat RL Proc. Natl. Acad. Sci. USA 88:7739-7743 (1991). RN [4] RA Herbst R. S., Friedman N., Darnell J. E., Babiss L. E. RT Positive and negative regulatory elements in the mouse albumin enhancer RL Proc. Natl. Acad. Sci. USA 86:1553-1557 (1989). RN [5] RA Lai E., Prezioso V. R., Smith E., Litvin O., Costa R. H., Darnell J. E. RT HNF-3A, a hepatocyte-enriched transcription factor RT of novel structure is regulated transcriptionally RL Genes Dev. 4:1427-1436 (1990). RN [6] RA Lai E., Prezioso V. R., Tao W., Chen W. S., Darnell J. E. RT Hepatocyte nuclear factor 3alpha belongs to a gene RT family in mammals that is homologous to the Drosophila RT homeotic gene fork head RL Genes Dev. 5:416-427 (1991). RN [7] RA Grange T., Roux J., Rigaud G., Pictet R. RT Cell-type specific activity of two glucocorticoid RT responsive units of rat tyrosine aminotransferase RT gene is associated with multiple binding sites for RT C/EBP and a novel liver-specific nuclear factor RL Nucleic Acids Res. 19:131-139 (1991). XX // AC T00372 XX ID T00372 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA HNF-4 XX SY HNF4; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.2.11.1. XX SZ 455 AA; 50.6 kDa (cDNA), 54 kDa (SDS) XX SQ MDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLGVSALCAICGDRATG SQ KHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEA SQ VQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKRIASITDVCE SQ SMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDY SQ IVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIK SQ RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL SQ LQEMLLGGSASDAPHAHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMSTPETPQPSPPS SQ GSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI XX SC SwissProt #P22449 XX CP liver, kidney, intestine XX FF transcriptional activator; FF may be identical to LF-A1; FF member of the steroid hormone receptor superfamily; FF may be antagonized by ARP-1 and/or COUP-TF [2]; XX MX M00134; V$HNF4_01 MX M00158; V$COUP_01 XX BS R02179; HNF4$CONS; Quality: 1 BS R00114; HS$A1ANTR_01; Quality: 1; human, Homo sapiens BS R02657; HS$APOC3_01; Quality: 1; human, Homo sapiens BS R03034; MOUSE$TTPA_05; Quality: 6; mouse, Mus musculus BS R03035; MOUSE$TTPA_06; Quality: 1; mouse, Mus musculus BS R03881; RAT$HNF1_02; Quality: 3; rat, Rattus norvegicus XX DR EMBL: X57133; RNHNF4(r). DR SwissProt: P22449; HNF4_RAT. DR PIR: A36471; A36471. DR Compel: C00041 DR Compel: C00122 DR Compel: C00129 XX RN [1] RA Tian J.-M., Schibler U. RT Tissue-specific expression of the gene encoding hepatocyte RT nuclear factor 1 may involve hepatocyte nuclear factor 4 RL Genes Dev. 5:2225-2234 (1991). RN [2] RA Mietus-Snyder M., Sladek F. M., Ginsburg G. S., Kuo RA C. F., Ladias J. A. A., Darnell Jr. J. E., Karathanasis S. K. RT Antagonism between apolipoprotein AI regulatory protein RT 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates RT apolipoprotein CIII gene expression in liver and intestinal cells RL Mol. Cell. Biol. 12:1708-1718 (1992). RN [3] RA Sladek F. M., Zhong W., Lai E., Darnell J. E., jr. - RT Liver-enriched transcription factor HNF-4 is a novel RT member of the steroid hormone receptor superfamily RL Genes Dev. 4:2353-2365 (1990). RN [4] RA Costa R. H., Grayson D. R., Darnell J. E. RT Multiple hepatocyte-enriched nuclear factors function RT in the regulation of transthyretin and alpha1-antitrypsin genes RL Mol. Cell. Biol. 9:1415-1425 (1989). RN [5] RA Paulson K. E., Darnell J. E., Rushmore T., Pickett C. B. RT Analysis of the upstream elements of the xenobiotic RT compound-inducible and positionally regulated glutathione RT S-transferase Ya gene RL Mol. Cell. Biol. 10:1841-1852 (1990). XX // AC T00373 XX ID T00373 XX DT 26.01.93 (created); hse. XX FA HNF-4 XX SY HNF4; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); 2.1.2.11.1. XX SZ 54 kDa (SDS) XX CP liver, kidney, intestine XX FF may be identical to LF-A1; FF member of the steroid hormone receptor superfamily XX MX M00134; V$HNF4_01 MX M00158; V$COUP_01 XX BS R02179; HNF4$CONS; Quality: 4 XX DR Compel: C00018 DR Compel: C00123 DR Compel: C00124 DR Compel: C00125 XX RN [1] RA Sladek F. M., Zhong W., Lai E., Darnell J. E., jr. - RT Liver-enriched transcription factor HNF-4 is a novel RT member of the steroid hormone receptor superfamily RL Genes Dev. 4:2353-2365 (1990). RN [2] RA Costa R. H., Grayson D. R., Darnell J. E. RT Multiple hepatocyte-enriched nuclear factors function RT in the regulation of transthyretin and alpha1-antitrypsin genes RL Mol. Cell. Biol. 9:1415-1425 (1989). RN [3] RA Paulson K. E., Darnell J. E., Rushmore T., Pickett C. B. RT Analysis of the upstream elements of the xenobiotic RT compound-inducible and positionally regulated glutathione RT S-transferase Ya gene RL Mol. Cell. Biol. 10:1841-1852 (1990). XX // AC T00375 XX ID T00375 XX DT 15.10.92 (created); ewi. XX FA HNF3(-like) XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01629; RAT$PEPCK_07; Quality: 6; rat, Rattus norvegicus BS R02895; XENLA$VITA2_03; Quality: 6; clawed frog, Xenopus laevis XX RN [1] RA Ip Y. T., Poon D., Stone D., Granner D. K., Chalkley R. RT Interaction of a Liver-Specific Factor with an Enhancer RT 4.8 Kilobases Upstream of the Phospholenolpyruvate Carboxykinase Gene RL Mol. Cell. Biol. 10:3770-3781 (1990). XX // AC T00376 XX ID T00376 XX DT 14.05.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA HOXD4 XX SY HHO.C13; HOX-5.1; HOX4B; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO Dfd (Drosophila) XX CL C0006; homeo; 3.1.1.2.15. XX SZ 255 AA; 27.9 kDa (cDNA) XX SQ MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGGGAQGADFQPPGLYPRPDFGEQ SQ PFGGSGPGPGSALPARGHGQEPGGPGGHYAAPGEPCPAPPAPPPAPLPGARAYSQSDPKQ SQ PPPGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLT SQ RRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSSSSCSSSVAPSQH SQ LQPMAKDHHTDLTTL XX SC SwissProt #P09016 XX FT 133 138 Antp-type hexapeptide FT 154 213 homeo domain FT 222 238 serine-rich region (13/17) XX SF low affinity to homeo domain binding sites in upstream SF homeobox genes (KD = 14.3-30.0 nM), high affinity SF binding to an element in the own promoter [2]; SF same DNA-binding specificity as insect Dfd and the paralogous HOXA4 [5]; XX CP embryonic brain, spinal chord, backbone, heart, limb buds [6]; XX FF inducible by retinoic acid [6]; FF two alternative promoters give rise to mRNAs of different FF expression patterns and different mRNA-stabilities [6]; FF positive autoregulation, but no activation of upstream genes [3], [1]; XX DR EMBL: X04706; HSHOM4(r). DR EMBL: X67079; HSHOX4B(g). DR EMBL: X17360; HSHOX51(g). DR SwissProt: P09016; HXD4_HUMAN. DR PIR: S10985; WJHU4B. XX RN [1] RA Arcioni L., Simeone A., Guazzi S., Zappavigna V., Boncinelli E., Mavilio F. RT The upstream region of the human homeobox gene HOX3D RT is a target for regulation by retinoic acid and HOX homeoproteins RL EMBO J. 11:265-277 (1992). RN [2] RA Corsetti M. T., Briata P., Sanseverino L., Daga A., RA Airoldi I., Simeone A., Palmisano G., Angelini C., Boncinelli E., Corte G. RT Differential DNA binding properties of three human homeodomain proteins RL Nucleic Acids Res. 20:4465-4472 (1992). RN [3] RA Malicki J., Cianetti L. C., Peschle C., McGinnis W. RT A human HOX4B regulatory element provides head specific RT expression in Drosophila embryos RL Nature 358:345-347 (1992). RN [4] RA Acampora D., Poiana G., Russo G., Peschle C., Boncinelli E. RT Differential and stage related expression in embryonic RT tissues of a new human homeobox gene RL Nature 324:664-668 (1986). RN [5] RA Dessain S., Gross C. T., Kuziora M. A., McGinnis W. RT Antp-type homeodomains have distinct DNA binding specificities RT that correlate with their different regulatory functions in embryos RL EMBO J. 11:991-1002 (1992). RN [6] RA Cianetti L., Di Cristofaro A., Zappavigna V., Bottero RA L., Boccoli G., Testa U., Russo G., Boncinelli E., Peschle C. RT Molecular mechanisms underlying the expression of the human HOX-5.1 gene RL Nucleic Acids Res. 18:4361-4368 (1990). XX // AC T00377 XX ID T00377 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA HOXA5 XX SY Chox-1.3 (chick); Hox-1.3; Hoxa-5; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO Scr (Drosophila) XX CL C0006; homeo; 3.1.1.2.16. XX SZ 270 AA; 29.2 kDa (cDNA) XX SQ MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSG SQ SGHFGSGERARSYAAGASAAPAEPRYSQPATSTHSPPPDPLPCSAVAPSPGSDSHHGGKN SQ SLGNSSGASANAGSTHISSREGVGTASAAEEDAPASSEQAGAQSEPSPAPPAQPQIYPWM SQ RKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIK SQ IWFQNRRMKWKKDNKLKSMSMAAAGGAFRP XX SC SwissProt #P09021 XX FT 176 181 Antp-type hexapeptide FT 195 254 homeo domain XX SF phosphorylation [6]; SF moderate affinity to homeo domain consensus sequence (KD = 5 nM) [5]; XX FF mutation causes homeotic transformations in cervical FF abnd thoracic regions [4]; FF the 7th cervical vertebra adopts thoracic-like features FF including the presence of a pair of ribs [4]; XX MX M00023; V$HOX13_01 XX BS R02638; HOX13$CONS; Quality: 6 BS R02635; MOUSE$HOX13_01; Quality: 6; mouse, Mus musculus BS R02636; MOUSE$HOX13_02; Quality: 6; mouse, Mus musculus BS R02637; MOUSE$HOX13_03; Quality: 6; mouse, Mus musculus BS R01678; MOUSE$NCAM_05; Quality: 6; mouse, Mus musculus XX DR EMBL: Y00208; MMHOX13(g). DR EMBL: M28021; MMHOX13A(r). DR EMBL: X16840; MMHX13(r). DR SwissProt: P09021; HXA5_MOUSE. DR PIR: S07812; WJMS13. XX RN [1] RA Hirsch M.-R., Gaugler L., Deagostini-Bazin H., Bally-Cuif L., Goridis C. RT Identification of Positive and Negative Regulatory RT Elements Governing Cell-Type-Specific Expression of RT the Neural Cell Adhesion Molecule Gene RL Mol. Cell. Biol. 10:1959-1968 (1990). RN [2] RA Odenwald W. F., Taylor C. F., Palmer-Hill F. J., Friedrich RA V. Jr., Tani M., Lazzarini R. A. RT Expression of a homeo domain protein in noncontact-inhibited RT cultured cells and postmitotic neurons RL Genes Dev. 1:482-496 (1987). RN [3] RA Fibi M., Zink B., Kessel M., Colbherg-Poley A. M., RA Labeit S., Lehrach H., Gruss P. RT Coding sequence and expression of the homeobox gene hox 1.3 RL Development 102:349-359 (1988). RN [4] RA Jeanotte L., Lemieux M., Charron J., Poirier F., Robertson E. J. RT Specification of axial identity in the mouse: role RT of the Hoxa-5 (Hox1.3) gene RL Genes Dev. 7:2085-2096 (1993). RN [5] RA Pellerin I., Schnabel C., Catron K. M., Abate C. RT Hox proteins have different affinities for a consensus RT DNA site that correlate with the positions of their genes on the hox cluster RL Mol. Cell. Biol. 14:4532-4545 (1994). RN [6] RA Odenwald W. F., Garbern J., Arnheiter H., Tournier-Lasserve RA E., Lazzarini R. A. RT The HOX-1.3 homeo box protein is a sequence-specific RT DNA-binding phosphoprotein RL Genes Dev. 3:158-172 (1989). XX // AC T00378 XX ID T00378 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA HOXA3 XX SY HOX1E (human); Hox-1.5; Hoxa-3; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO Pb (Drosophila) XX CL C0006; homeo; 3.1.1.2.9. XX SQ GPPGQASSKRGRTAYTRPQLVELEKEFHFNRYLMRPRRVEMANLLNLTERQIKIWFQNRR SQ MKYKKDQKGKGMLT XX SC SwissProt #P02831 XX SF differential binding specificity in comparison with SF Msx-1 or En-1 is defined by nucleotides 3'-flanking SF to the TAAT core of the recognition sequence due to kinetic reasons [1]; XX CP aortic trunk, kidney, lung, pharynx, spinal cord, CP spinal ganglia, spleen, stomach, thyroid [3]; XX FF equired for development of thymus and parathyroid FF and for full development of thyroid and submaxillary tissue [3]; FF mutants have defects in heart and arteries and reveal FF cranofacial abnormalities, similar to human DiGeorge's syndrome [3]; FF subject to autoregulation [4]; XX BS R00723; MOUSE$HOX15_01; Quality: 6; mouse, Mus musculus XX DR EMBL: K02591; MMHOM(g). DR SwissProt: P02831; HXA3_MOUSE. DR PIR: A03315; A03315. XX RN [1] RA Catron K. M., Iller N., Abate C. RT Nucleotides flanking a conserved TAAT core dictate RT the DNA binding specifity of three murine homeodomain proteins RL Mol. Cell. Biol. 13:2354-2365 (1993). RN [2] RA McGinnis W., Hart C. P., Gehring W. J., Ruddle F. H. RT Molecular cloning and chromosome mapping of a mouse RT DNA sequence homologous to homeotic genes of Drosophila RL Cell 38:675-680 (1984). RN [3] RA Chisaka O., Capecchi M. R. RT Regionally restricted developmental defects resulting RT from targeted disruption of the mouse homeobox gene hox-1.5 RL Nature 350:473-479 (1991). RN [4] RA Fainsod A., Bogarad L. D., Ruusala T., Lubin M., Crothers RA D. M., Ruddle F. H. RT The homeo domain of a murine protein binds 5' to its own homeo box RL Proc. Natl. Acad. Sci. USA 83:9532-9536 (1986). XX // AC T00379 XX ID T00379 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA HP1 site factor XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO HNF-1, LF-B1, APF XX BS R00123; HS$A1ANTR_10; Quality: 6; human, Homo sapiens BS R00434; MOUSE$AFEP_01; Quality: 6; mouse, Mus musculus BS R00091; MOUSE$ALBU_10; Quality: 6; mouse, Mus musculus BS R01625; RAT$A1I3_03; Quality: 6; rat, Rattus norvegicus BS R00440; RAT$BF_04; Quality: 6; rat, Rattus norvegicus BS R00100; XEN$ALBU_24; Quality: 6; clawed frog, Xenopus XX RN [1] RA Kugler W., Wagner U., Ryffel G. U. RT Tissue-specificity of liver gene expression: a common RT liver-specific promoter element RL Nucleic Acids Res. 16:3165-3174 (1988). XX // AC T00380 XX ID T00380 XX DT 26.01.93 (created); hse. DT 15.03.94 (updated); hwi. XX FA H2RIIBP XX SY RXR-beta; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); . XX SZ 50 kDa (SDS, cDNA) XX FF member of the steroid hormone receptor superfamily, FF binds to the cAMP response element and to the ER site XX BS R02166; H2RIIBP$CONS; Quality: 2 XX DR EMBL: X65463; HSPBP3(g). XX RN [1] RA Hamada K., Gleason S., Levi B.-Z., Hirschfeld S., Apella E., Ozato K. RT H-2RIIBP, a member of the nuclear hormone receptor RT superfamily that binds to both the regulatory element RT of major histocompatibility class I genes and the estrogen response element RL Proc. Natl. Acad. Sci. USA 86:8289-8293 (1989). XX // AC T00381 XX ID T00381 XX DT 17.11.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA HrpF XX SY XrpFI (X. laevis); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO alpha factor (mouse) XX FF regulator of ribosomal protein synthesis XX BS R01326; MOUSE$RPL32_01; Quality: 6; mouse, Mus musculus BS R02383; XENLA$RPL14_01; Quality: 6; clawed frog, Xenopus laevis XX RN [1] RA Lagna G., Loreni F., Beccari E., Carnevali F. RT HrpF, a human sequence-specific DNA-binding protein RT homologous to XrpFI, a Xenopus laevis oocyte transcription factor RL Nucleic Acids Res. 18:5811 (1990). XX // AC T00382 XX ID T00382 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA HSE-binding protein XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX HO HSTF XX SZ 150 kDa XX RN [1] RA Sorger P. K., Pelham H. R. B. RT Purification and characterization of a heat-shock RT element binding protein from yeast RL EMBO J. 6:3035-3041 (1987). XX // AC T00383 XX ID T00383 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA HSF XX SY HSTF; HTF; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO heat-induced factor XX CL ; ; 3.4.1.0.1.1. XX SZ 83 kDa (SDS), 4-5S (inactive), 8S (active) XX SF phosphorylation XX CP (HeLa) XX FF binds to DNA, not to nucleosome-assembled DNA unless FF TBP was present during assembly XX IN T01264; HST; yeast, Kluyveromyces lactis. XX BS R01925; AS$HSF_02; Quality: 4 BS R03331; AS$HSF_03; Quality: 6 BS R03624; AS$HSF_05; Quality: 6 BS R00756; DROME$HSP70_06; Quality: 2; fruit fly, Drosophila melanogaster BS R00773; DROME$HSP83_01; Quality: 6; fruit fly, Drosophila melanogaster BS R00762; HS$HSP70_03; Quality: 6; human, Homo sapiens BS R00763; HS$HSP70_04; Quality: 6; human, Homo sapiens BS R00764; HS$HSP70_05; Quality: 6; human, Homo sapiens BS R02181; HSF$CONS; Quality: 6 XX DR EMBL: M64673; HSHSF1(r). DR EMBL: M65217; HSHSF2(r). XX RN [1] RA Kimura Y., Taniguchi T., Yahara I. RT An alteration in molecular form associated with activation RT of human heat shock factor RL Cell Struct. & Func. 16:263-271 (1991). RN [2] RA Goldenberg C. J., Luo Y., Fenna M., Baler R., Weinmann R., Voellmy R. RT Purified Human Factor Activates Heat Shock Promoter RT in a HeLa Cell-free Transcription System RL J. Biol. Chem. 263:19734-19739 (1988). RN [3] RA Morgan W. D., Williams G. T., Morimoto R. I., Greene RA J., Kingston R. E., Tjian R. RT Two transcriptional activators, CCAAT-box-binding RT transcription factor and heat shock transcription RT factor, interact with a human hsp70 gene promoter RL Mol. Cell. Biol. 7:1129-1138 (1987). RN [4] RA Mosser D. D., Theodorakis N. G., Morimoto R. I. RT Coordinate Changes in Heat Shock Element-Binding Acitvity RT and HSP70 Gene Transcription Rates in Human Cells RL Mol. Cell. Biol. 8:4736-4744 (1988). RN [5] RA Larson J. S., Schuetz T. J., Kingston R. E. RT Activation in vitro of sequence-specific DNA binding RT by a human regulatory factor RL Nature 335:372-375 (1988). RN [6] RA Cunniff N. F. A., Wagner J., Morgan W. D. RT Modular recognition of 5-base-pair DNA sequence motifs RT by human heat shock transcription factor RL Mol. Cell. Biol. 11:3504-3514 (1991). RN [7] RA Taylor I. C. A., Workman J. L., Schuetz T. J., Kingston R. E. RT Facilitated binding of GAL4 and heat shock factor RT to nucleosomal templates: differential function of DNA-binding domains RL Genes Dev. 5:1285-1298 (1991). RN [8] RA Abravaya K., Phillips B., Morimoto R. I. RT Heat shock-induced interactions of heat shock-transcription RT factor and the human hsp70 promoter examined by in vivo footprinting RL Mol. Cell. Biol. 11:586-592 (1991). RN [9] RA Sorger P. K. RT Heat shock factor and the heat shock response RL Cell 65:363-366 (1991). RN [10] RA Cunnif N. F. A., Wagner J., Morgan W. D. RT Modular recognition of 5-base-pair DNA sequence motifs RT by human heat shock transcription factor RL Mol. Cell. Biol. 11:3504-3514 (1991). XX // AC T00384 XX ID T00384 XX DT 26.01.93 (created); hse. DT 20.02.97 (updated); ewi. XX FA HSF XX SY HSF1; HTF; heat shock transcription factor 1; mHSF1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 3.4.1.0.1.2. XX SZ 503 AA; 54.9 kDa (cDNA) XX SQ MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY SQ FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT SQ SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA SQ QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY SQ SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE SQ PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL SQ PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDIQELLSPQ SQ EPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDY SQ TDDPTISLLTGTEPHKAKDPTVS XX SC SwissProt #P38532 XX FT 16 120 DNA-binding domain XX SF 4 potential leucine zippers XX CP (C2C12) XX FF does not bind prior to or after recovery from heat shock; FF induced to DNA-binding by heat (within minutes [4]) FF or other stress factors [4] such as hypoxia [3], FF [13], metabolic inhibition by rotenone or ATP depletion FF (K+/nigericin) [3], or prostaglandins [5], [6]; FF activation depends on Ca2+ ions and on a phosphorylation step [2], [4]; XX IN T01264; HST; yeast, Kluyveromyces lactis. XX BS R01773; AS$HSF_01; Quality: 4 BS R01925; AS$HSF_02; Quality: 4 BS R03465; AS$HSF_04; Quality: 2 BS R00762; HS$HSP70_03; Quality: 6; human, Homo sapiens BS R00764; HS$HSP70_05; Quality: 6; human, Homo sapiens BS R02181; HSF$CONS; Quality: 6 BS R03464; MOUSE$HSP70_01; Quality: 6; mouse, Mus musculus XX DR EMBL: X61753; MMHSF1(r). DR SwissProt: P38532; HSF1_MOUSE. DR PIR: A40583; A40583. XX RN [1] RA Sarge K. D., Zimarino V., Holm K., Wu C., Morimoto R. I. RT Cloning and characterization of two mouse heat shock RT factors with distinct inducible and constitutive DNA-binding ability RL Genes Dev. 5:1902-1911 (1991). RN [2] RA Price B. D., Calderwood S. K. RT Ca2+ is essential for multistep activation of the RT heat shock factor in permeabilized RL Mol. Cell. Biol. 11:3365-3368 (1991). RN [3] RA Benjamin I. J., Horie S., Greenberg M. L., Alpern R. J., Williams R. S. RT Induction of stress proteins in cultured myogenic cells RL J. Clin. Invest. 89:1585-1589 (1992). RN [4] RA Sarge K. D., Murphy S. P., Morimoto R. I. RT Activation of heat shock gene transcription by heat RT shockfactor 1 involves oligomerization, acquisition RT of DNA-binding activity, and nuclear localization RT and can occur in the absence of stress RL Mol. Cell. Biol. 13:1392-1407 (1993). RN [5] RA Amici C., Sistonen L., Santoro M. G., Morimoto R. I. RT Antiproliferative prostaglandins activate heat shock transcription factor RL Proc. Natl. Acad. Sci. USA 89:6227-6231 (1992). RN [6] RA Koizumi T., Negishi M., Ichikawa A. RT Activation of heat shock transcription factors by RT delta12-prostaglandin J2 and its inhibition by intracellular glutathione RL Biochem. Pharmacol. 45:2457-2464 (1993). RN [7] RA Abravaya K., Phillips B., Morimoto R. I. RT Heat shock-induced interactions of heat shock transcription RT factor and the human hsp70 promoter examined by in vivo footprinting RL Mol. Cell. Biol. 11:586-592 (1991). RN [8] RA Goldenberg C. J., Luo Y., Fenna M., Baler R., Weinmann R., Voellmy R. RT Purified Human Factor Activates Heat Shock Promoter RT in a HeLa Cell-free Transcription System RL J. Biol. Chem. 263:19734-19739 (1988). RN [9] RA Cunniff N. F. A., Wagner J., Morgan W. D. RT Modular recognition of 5-base-pair DNA sequence motifs RT by human heat shock transcription factor RL Mol. Cell. Biol. 11:3504-3514 (1991). RN [10] RA Abravaya K., Phillips B., Morimoto R. I. RT Heat shock-induced interactions of heat shock-transcription RT factor and the human hsp70 promoter examined by in vivo footprinting RL Mol. Cell. Biol. 11:586-592 (1991). RN [11] RA Sorger P. K. RT Heat shock factor and the heat shock response RL Cell 65:363-366 (1991). RN [12] RA Cunnif N. F. A., Wagner J., Morgan W. D. RT Modular recognition of 5-base-pair DNA sequence motifs RT by human heat shock transcription factor RL Mol. Cell. Biol. 11:3504-3514 (1991). RN [13] RA Benjamin I. J., Kroeger B., Williams R. S. RT Activation of the heat shock transcription factor RT by hypoxia in mammalian cells RL Proc. Natl. Acad. Sci. USA 87:6263-6267 (1990). XX // AC T00385 XX ID T00385 XX DT 15.10.92 (created); ewi. DT 20.02.97 (updated); ewi. XX FA HSTF XX SY HSF; heat shock transcription factor; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 3.4.1.0.8. XX SZ 833 AA; 93.3 kDa (cDNA), 130-150 kDa (SDS) XX SQ MNNAANTGTTNESNVSDAPRIEPLPSLNDDDIEKILQPNDIFTTDRTDASTTSSTAIEDI SQ INPSLDPQSAASPVPSSSFFHDSRKPSTSTHLVRRGTPLGIYQTNLYGHNSRENTNPNST SQ LLSSKLLAHPPVPYGQNPDLLQHAVYRAQPSSGTTNAQPRQTTRRYQSHKSRPAFVNKLW SQ SMLNDDSNTKLIQWAEDGKSFIVTNREEFVHQILPKYFKHSNFASFVRQLNMYGWHKVQD SQ VKSGSIQSSSDDKWQFENENFIRGREDLLEKIIRQKGSSNNHNSPSGNGNPANGSNIPLD SQ NAAGSNNSNNNISSSNSFFNNGHLLQGKTLRLMNEANLGDKNDVTAILGELEQIKYNQIA SQ ISKDLLRINKDNELLWQENMMARERHRTQQQALEKMFRFLTSIVPHLDPKMIMDGLGDPK SQ VNNEKLNSANNIGLNRDNTGTIDELKSNDSFINDDRNSFTNATTNARNNMSPNNDDNSID SQ TASTNTTNRKKNIDENIKNNNDIINDIIFNTNLANNLSNYNSNNNAGSPIRPYKQRYLLK SQ NRANSSTSSENPSLTPFDIESNNDRKISEIPFDDEEEEETDFRPFTSRDPNNQTSENTFD SQ PNRFTMLSDDDLKKDSHTNDNKHNESDLFWDNVHRNIDEQDARLQNLENMVHILSPGYPN SQ KSFNNKTSSTNTNSNMESAVNVNSPGFNLQDYLTGESNSPNSVHSVPSNGSGSTPLPMPN SQ DNDTEHASTSVNQGENGSGLTPFLTVDDHTLNDNNTSEGSTRVSPDIKFSATENTKVSDN SQ LPSFNDHSYSTQADTAPENAKKRFVEEIPEPAIVEIQDPTEYNDHRLPKRAKK XX SC SwissProt #P10961 XX FT 43 90 serine-/threonine-rich region (20/48) FT 167 284 DNA-binding domain [9]; FT 569 581 acidic region (9/13) FT 327 424 trimerization through 2 alpha-helices FT forming a putative 3-stranded parallel coiled coil XX SF phosphorylation [4], [12]; SF 2 activation domains within the N-terminus (for transient SF activity) and within the C-terminus (for sustained activity) [2]; SF at least one of them is masked under non-induced conditions [3]; SF trimerization through the hydrophobic heptad repeats SF of 2 alpha-helices that may form a 3-stranded parallel coiled-coil [1]; SF DNA-binding and oligomerization domain determine temperature-dependent SF regulation [5]; XX FF activator, essential for growth, mediating expression FF of heat-shock genes in response to elevated temperatures [12], [9]; FF transient induction by heat) [7]; FF binds simultaneously with URSF to SSA1 promoter, but FF displaces URSF upon heat shock; FF activation domain is repressed under non-shock conditions; FF N-terminal sequences lead to the transient increase FF in HSF activation, C-terminal sequences to sustained FF increase concomitant with phosphorylation [5], presumably FF by SNF1 protein kinase [7]; XX IN T00385; HSTF; yeast, Saccharomyces cerevisiae. IN T01264; HST; yeast, Kluyveromyces lactis. XX MX M00029; F$HSF_01 MX M00167; F$HSF_02 MX M00168; F$HSF_03 MX M00169; F$HSF_04 MX M00170; F$HSF_05 XX BS R03823; AS$HSE_06; Quality: 1 BS R03824; AS$HSE_07; Quality: 1 BS R01773; AS$HSF_01; Quality: 4 BS R03465; AS$HSF_04; Quality: 6 BS R00751; DROME$HSP70_01; Quality: 6; fruit fly, Drosophila melanogaster BS R00754; DROME$HSP70_04; Quality: 6; fruit fly, Drosophila melanogaster BS R00756; DROME$HSP70_06; Quality: 2; fruit fly, Drosophila melanogaster BS R01043; Y$CUP1_04; Quality: 2; yeast, Saccharomyces cerevisiae BS R03320; Y$CUP1_08; Quality: 2; yeast, Saccharomyces cerevisiae BS R00771; Y$HSP70_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R00775; Y$HSP83_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R00776; Y$HSP83_04; Quality: 2; yeast, Saccharomyces cerevisiae BS R03007; Y$SSA3_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R03862; Y$SSA4_01; Quality: 5; yeast, Saccharomyces cerevisiae XX DR EMBL: J03139; SCHSF(g). DR EMBL: M22040; SCHSF1A(g). DR SwissProt: P10961; HSF_YEAST. DR PIR: A31592; A31592. DR PIR: A31593; A31593. XX RN [1] RA Sorger P. K., Nelson H. C. M. RT Trimerization of a yeast transcriptional activator via a coiled-coil motif RL Cell 59:807-813 (1989). RN [2] RA Sorger P. K. RT Yeast heat shock factor contains separable transient RT and sustained response transcriptional activators RL Cell 62:793-805 (1990). RN [3] RA Nieto-Sotelo J., Wiederrecht G., Okuda A., Parker C. S. RT The yeast heat shock transcription factor contains RT a transcription activation domain whose activity is RT repressed under nonshock conditions RL Cell 62:807-817 (1990). RN [4] RA Sorger P. K., Pelham H. R. B. RT Purification and characterization of a heat-shock RT element binding protein from yeast RL EMBO J. 6:3035-3041 (1987). RN [5] RA Bonner J. J., Heyward S., Fackenthal D. L. RT Temperature-dependent regulation of a heterologous RT transcriptional activation domain fused to yeast heat RT shock transcription factor RL Mol. Cell. Biol. 12:1021-1030 (1992). RN [6] RA Harrison C. J., Bohm A. A., Nelson H. C. M. RT Crystal structure of the DNA binding domain of the RT heat shock transcription factor RL Science 263:224-227 (1994). RN [7] RA Tamai K. T., Liu X., Silar P., Sosinowski T., Thiele D. J. RT Heat shock transcription factor activates yeast metallothionein RT gene expression in response to heat and glucose starvation RT via distinct signalling pathways RL Mol. Cell. Biol. 14:8155-8165 (1994). RN [8] RA Wiederrecht G., Shuey D. J., Kibbe W. A., Parker C. S. RT The Saccharomyces and Drosophila heat shock transcription RT factors are identical in size and DNA binding properties RL Cell 48:507-515 (1987). RN [9] RA Wiederrecht G., Seto D., Parker C. RT Isolation of the Gene Encoding the S. cerevisiae Heat RT Shock Transcription Factor RL Cell 54:841-853 (1988). RN [10] RA Park H.-O., Craig E. A. RT Positive and Negative Regulation of Basal Expression of a Yeast HSP70 Gene RL Mol. Cell. Biol. 9:2025-2033 (1989). RN [11] RA Park H.-O., Craig E. A. RT Transcriptional regulation of a yeast HSP70 gene by RT heat shock factor and an upstream repression site-binding factor RL Genes Dev. 5:1299-1308 (1991). RN [12] RA Sorger P. K., Pelham H. R. B. RT Yeast Heat Shock Protein Is an Essential DNA-Binding RT Protein That Exhibits Temperature-Dependent Phosphorylation RL Cell 54:855-864 (1988). XX // AC T00386 XX ID T00386 XX DT 15.10.92 (created); ewi. DT 20.02.97 (updated); ewi. XX FA HSTF XX SY HAP; HSF; heat shock transcription factor; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL ; ; 3.4.1.0.4. XX SZ 691 AA; 76.9 kDa (cDNA) XX SQ MSRSRSSAKAVQFKHESEEEEEDEEEQLPSRRMHSYGDAAAIGSGVPAFLAKLWRLVDDA SQ DTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYGFHKITSIDNGGL SQ RFDRDEIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTDVKVMRGRQ SQ DNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKRHVQ SQ LMINNTPEIDRARTTSETESESGGGPVIHELREELLDEVMNPSPAGYTAASHYDQESVSP SQ PAVERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQSVSQSPAQHD SQ VYTVTEAPDSHVQEVPNSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVILD SQ AGDILVDSSSPKAQRTSIQHSTQPDVMVQPMIIKSEPENSSGLMDLMTPANDLYSVNFIS SQ EDMPTDIFEDALLPDGVEEAAKLDQQQKFGQSTVSSGKFASNFDVPTNSTLLDANQASTS SQ KAAAKAQASEEEGMAVAKYSGAENGNNRDTNNSQLLRMASVDELHGHLESMQDELETLKD SQ LLRGDGVAIDQNMLMGLFNDSDLMDNYGLSFPNDSISSEKKAPSGSELISYQPMYDLSDI SQ LDTDDGNNDQEASRRQMQTQSSVLNTPRHEL XX SC SwissProt #P22813 XX FT 579 610 hydrophobic repeat XX SF asymmetric molecular shape of the monomer, even higher SF asymmetry found for the trimer [3]; XX FF cooperative DNA-binding to multiple elements (HSE) FF after trimerization [9], [3], [2]; FF inducing signals cause a transition from the inactive FF monomeric to the active trimeric state [3]; XX IN T01264; HST; yeast, Kluyveromyces lactis. XX MX M00028; I$HSF_01 MX M00163; I$HSF_02 MX M00164; I$HSF_03 MX M00165; I$HSF_04 MX M00166; I$HSF_05 XX BS R00751; DROME$HSP70_01; Quality: 6; fruit fly, Drosophila melanogaster BS R00752; DROME$HSP70_02; Quality: 6; fruit fly, Drosophila melanogaster BS R00753; DROME$HSP70_03; Quality: 6; fruit fly, Drosophila melanogaster BS R00754; DROME$HSP70_04; Quality: 6; fruit fly, Drosophila melanogaster BS R00755; DROME$HSP70_05; Quality: 6; fruit fly, Drosophila melanogaster BS R00756; DROME$HSP70_06; Quality: 4; fruit fly, Drosophila melanogaster BS R00773; DROME$HSP83_01; Quality: 6; fruit fly, Drosophila melanogaster BS R00762; HS$HSP70_03; Quality: 6; human, Homo sapiens BS R00775; Y$HSP83_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R00776; Y$HSP83_04; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: M60070; DMHSPHEX(r). DR SwissProt: P22813; HSF_DROME. DR PIR: A36295; A36295. DR Flybase: FBgn0001222; Hsf. DR PDB: 1hks; HEAT SHOCK TRANSCRIPTION FACTOR (NMR, RESTRAINED MINIMIZED AVERAGE STRUCTURE) D. MELANOGASTER. DR PDB: 1hkt; HEAT SHOCK TRANSCRIPTION FACTOR (NMR, 28 STRUCTURES) DROSOPHILA MELANOGASTER. XX RN [1] RA Gallo G. J., Prentice H., Kingston R. E. RT Heat shock factor is required for growth at normal RT temperatures in the fission yeast Schizosaccharomyces pombe RL Mol. Cell. Biol. 13:749-761 (1993). RN [2] RA Rabindran S. K., Haroun R. I., Clos J., Wisniewski J., Wu C. RT Regulation of heat shock factor trimer formation: RT role of a conserved leucine zipper RL Science 259:230-234 (1993). RN [3] RA Westwood J. T., Wu C. RT Activation of Drosophila heat shock factor: conformational RT change associated with a monomer-to-trimer transition RL Mol. Cell. Biol. 13:3481-3486 (1993). RN [4] RA Perisic O., Xiao H., Lis J. T. RT Stable Binding of Drosophila Heat Shock Factor to RT Head-to-Head and Tail-to-Tail Repeats of a Conserved 5 bp Recognition Unit RL Cell 59:797-806 (1989). RN [5] RA Topol J., Ruden D. M., Parker C. S. RT Sequences required for in vitro transcriptional activation RT of a Drosophila hsp 70 gene RL Cell 42:527-537 (1985). RN [6] RA Wiederrecht G., Shuey D. J., Kibbe W. A., Parker C. S. RT The Saccharomyces and Drosophila heat shock transcription RT factors are identical in size and DNA binding properties RL Cell 48:507-515 (1987). RN [7] RA Wu C. RT Two protein-binding sites in chromatin implicated RT in the activation of heat-shock genes RL Nature 309:229-234 (1984). RN [8] RA Xiao H., Perisic O., Lis J. T. RT Cooperative binding of Drosophila heat shock factor RT to arrays of a conserved 5 bp unit RL Cell 64:585-593 (1991). RN [9] RA Shuey D. J., Parker C. S. RT Binding of Drosophila Heat-Shock Gene Transcription RT Factor to the hsp 70 Promoter RL J. Biol. Chem. 261:7934-7940 (1986). XX // AC T00387 XX ID T00387 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); hse; ewi. XX FA H1TF1 XX SY H1TF-1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO HiNF-B XX SZ 90 kDa? (SDS) XX CP (HeLa) XX BS R02164; H1TF1$CONS; Quality: 6 BS R00659; HS$HH1_02; Quality: 6; human, Homo sapiens XX RN [1] RA La Bella F., Gallinari P., McKinney J., Heintz N. RT Histone H1 subtype-specific consensus element mediate RT cell cycle-regulated transcription in vitro RL Genes Dev. 3:1982-1990 (1990). RN [2] RA Gallinari P., La Bella F., Heintz N. RT Characterization and Purification of H1TF2, a Novel RT CCAAT-Binding Protein That Interacts with a Histone RT H1 Subtype-Specific Consensus Element RL Mol. Cell. Biol. 9:1566-1575 (1989). XX // AC T00388 XX ID T00388 XX DT 15.10.92 (created); ewi. XX FA H1TF2 XX SY H1TF-2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 47 kDa XX CP (HeLa) XX FF upregulated during S phase; FF different from CTF/NF-1; FF C/EBP; FF alpha-CP1, alpha-CP2; FF HiNF-A & -B XX BS R02165; H1TF2$CONS; Quality: 6 BS R00660; HS$HH1_03; Quality: 6; human, Homo sapiens XX RN [1] RA La Bella F., Gallinari P., McKinney J., Heintz N. RT Histone H1 subtype-specific consensus element mediate RT cell cycle-regulated transcription in vitro RL Genes Dev. 3:1982-1990 (1990). RN [2] RA Gallinari P., La Bella F., Heintz N. RT Characterization and Purification of H1TF2, a Novel RT CCAAT-Binding Protein That Interacts with a Histone RT H1 Subtype-Specific Consensus Element RL Mol. Cell. Biol. 9:1566-1575 (1989). XX // AC T00389 XX ID T00389 XX DT 26.01.93 (created); hse. DT 10.01.96 (updated); hiwi. XX FA H2TF1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; . XX SZ 48, 58 kDa (SDS) XX SF 2 zinc finger motifs XX FF Exists in two forms, constitutively expressed. Binds FF to the kappaB motif. Implicated in MHC class II expression XX BS R02167; H2TF1$CONS; Quality: 6 BS R01057; MOUSE$M1H2KB_05; Quality: 6; mouse, Mus musculus XX RN [1] RA Lenardo M., Rustgi A. K., Schievella A. R., Bernards R. RT Suppression of MHC class I gene expression by N-myc RT through enhancer inactivation RL EMBO J. 8:3351-3355 (1989). RN [2] RA Gilmore T. D. RT NF-kappaB, KBF1, dorsal, and related matters RL Cell 62:841-843 (1990). RN [3] RA Henseling U., Schmidt W., Schoeler H. R., Gruss P., Hatzopoulos A. K. RT A transcription factor interacting with the class RT I gene enhancer is inactive in tumorigenic cell lines RT which suppress major histocompatibility complex class I genes RL Mol. Cell. Biol. 10:4100-4109 (1990). RN [4] RA Rustgi A. K., Van'T Veer L. J., Bernards R. RT Two genes encode factors with NF-kappaB- and H2TF1-like RT DNA-binding properties RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990). XX // AC T00390 XX ID T00390 XX DT 15.10.92 (created); ewi. DT 15.03.94 (updated); hwi. XX FA H2TF1 XX SY HeLa B factor; KBF1; TC-IIC; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R02167; H2TF1$CONS; Quality: 6 BS R02189; KBF1$CONS; Quality: 6 BS R01057; MOUSE$M1H2KB_05; Quality: 6; mouse, Mus musculus BS R01059; MOUSE$M1H2KB_07; Quality: 6; mouse, Mus musculus BS R01065; MOUSE$M1H2LD_03; Quality: 6; mouse, Mus musculus XX RN [1] RA Baldwin A. S., Sharp P. A. RT Binding of a Nuclear Factor to a Regulatory Sequence RT in the Promoter of the Mouse H-2Kb Class I Major Histocompatibility Gene RL Mol. Cell. Biol. 7:305-313 (1987). RN [2] RA Baldwin Jr. A. S., Sharp P. A. RT Two transcription factors, NF-kB and H2TF1, interact RT with a single regulatory sequence in the class I major RT histocompatibility complex promoter RL Proc. Natl. Acad. Sci. USA 85:723-727 (1988). RN [3] RA Mauxion F., Sen R. RT Alteration of a Single Nucleotide Allows Efficient RT Binding of H2TF1/KBF1 to the Immunoglobulin k Enhancer B Motif RL Mol. Cell. Biol. 9:3548-3552 (1989). XX // AC T00391 XX ID T00391 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA H4TF-1 XX SY H4TF1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO HiNF-A XX SZ 105+110 kDa (SDS-UV) XX SF zinc-dependent XX CP (HeLa) XX FF factor level is constant during cell cycle XX BS R02168; H4TF1$CONS; Quality: 6 BS R00680; HS$HH4_01; Quality: 6; human, Homo sapiens XX RN [1] RA La Bella F., Heintz N. RT Histone gene transcription factor binding in extracts of normal human cells RL Mol. Cell. Biol. 11:5825-5831 (1991). RN [2] RA Dailey L., Boseman Roberts S., Heintz N. RT RNA polymerase II transcription factors H4TF-1 and RT H4TF-2 require metal to bind specific DNA sequences RL Mol. Cell. Biol. 7:4582-4584 (1987). RN [3] RA Dailey L., Boseman Roberts S., Heintz N. RT Purification of the human histone H4 gene-specific RT transcription factors H4TF-1 and H4TF-2 RL Genes Dev. 2:1700-1712 (1988). RN [4] RA Dailey L., Hanly S. M., Roeder R. G., Heintz N. RT Distinct transcription factors bind specifically to RT two regions of the human histone H4 promoter RL Proc. Natl. Acad. Sci. USA 83:7241-7245 (1986). XX // AC T00392 XX ID T00392 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA H4TF-2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO HiNF-P XX SZ 65 kDa (SDS) XX SF zinc finger ? (zinc-dependent) XX CP (HeLa) XX FF factor level is constant during cell cycle XX BS R02169; H4TF2$CONS; Quality: 6 BS R00681; HS$HH4_02; Quality: 6; human, Homo sapiens XX RN [1] RA La Bella F., Heintz N. RT Histone gene transcription factor binding in extracts of normal human cells RL Mol. Cell. Biol. 11:5825-5831 (1991). RN [2] RA Dailey L., Boseman Roberts S., Heintz N. RT RNA polymerase II transcription factors H4TF-1 and RT H4TF-2 require metal to bind specific DNA sequences RL Mol. Cell. Biol. 7:4582-4584 (1987). RN [3] RA Dailey L., Boseman Roberts S., Heintz N. RT Purification of the human histone H4 gene-specific RT transcription factors H4TF-1 and H4TF-2 RL Genes Dev. 2:1700-1712 (1988). RN [4] RA Dailey L., Hanly S. M., Roeder R. G., Heintz N. RT Distinct transcription factors bind specifically to RT two regions of the human histone H4 promoter RL Proc. Natl. Acad. Sci. USA 83:7241-7245 (1986). XX // AC T00394 XX ID T00394 XX DT 15.10.92 (created); ewi. DT 04.11.96 (updated); ewi. XX FA NF-kappaB2 XX SY Lyt-10; NF-kappaB2 (p52); p52; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0020; Rel; 4.1.1.0.2.2. XX SZ 52 kDa (SDS) XX FT 38 241 Rel homology region FT 351 404 glycine-rich region (24/54), glycine hinge XX SF N-terminal half of a 100-kDa precursor (T01927) from SF which it is released by proteolytic clipping [10]; XX CP ubiquitous XX FF constitutive activator when heterodimerized with RelB [8]; FF transcriptionally inert DNA-binding homodimer forms FF trans-activating ternary complexes with Bcl-3 [5], [3]; FF the NFKB2 gene contains two promoters [7]; FF at least four kappaB sites mediate positive autoregulation FF in response to phorbol esters or TNF-alpha [7]; XX IN T00168; c-Rel; human, Homo sapiens. IN T00593; NF-kappaB1; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T01928; Bcl-3; human, Homo sapiens. IN T01931; RelB; human, Homo sapiens. IN T01932; RelB; mouse, Mus musculus. XX MX M00208; V$NFKB_C XX BS R00922; HS$IFNB_07; Quality: 6; human, Homo sapiens BS R01059; MOUSE$M1H2KB_07; Quality: 6; mouse, Mus musculus XX RN [1] RA Fujita T., Miyamoto M., Kimura Y., Hammer J., Taniguchi T. RT Involvement of a cis-element that binds an H2TF-1/NFkappaB RT like factor(s) in the virus-induced interferon-beta gene expression RL Nucleic Acids Res. 17:3335-3346 (1989). RN [2] RA Schmid R. M., Perkins N. D., Duckett C. S., Andrews P. C., Nabel G. J. RT Cloning of an NF-kappaB subunit which stimulates HIV RT transcription in synergy with p65 RL Nature 352:733-736 (1991). RN [3] RA Pan J., McEver R. P. RT Regulation of the human P-selection promoter by Bcl-3 RT and specific homodimeric members of the NF-kappaB/Rel family RL J. Biol. Chem. 270:23077-23083 (1995). RN [4] RA Naumann M., Scheidereit C. RT Activation of NF-6B in vivo is regulated by multiple phosphorylations RL EMBO J. 13:4597-4607 (1994). RN [5] RA Bours V., Franzoso G., Azarenko V., Park S., Kanno RA T., Brown K., Siebenlist U. RT The oncoprotein Bcl-3 directly transactivates through RT kappaB motifs via association with DNA-binding p50B homodimers RL Cell 72:729-739 (1993). RN [6] RA Potter D. A., Larson C. J., Eckes P., Schmid R. M., RA Nabel G. J., Verdine G. L., Sharp P. A. RT Purification of the major histocompatibility complex RT class I transcription factor H2TF1. The full-length RT product of the nfkb2 gene RL J. Biol. Chem. 268:18882-18890 (1993). RN [7] RA Liptay S., Schmid R. M., Nabel E. G., Nabel G. J. RT Transcriptional regulation of NF-kappaB2: evidence RT for kappaB-mediated positive and negative autoregulation RL Mol. Cell. Biol. 14:7695-7703 (1994). RN [8] RA Dobrzanski P., Ryseck R.-P., Bravo R. RT Differential interactions of RelB-NF-kappaB complexes RT with IkappaBalpha determine pools of constitutive RT and inducible NF-kappaB activity RL EMBO J. 13:4608-4616 (1994). RN [9] RA Bours V., Burd P. R., Brown K., Villalobos J., Park RA S., Ryseck R. P., Bravo R., Kelly K., Siebenlist U. RT A novel mitogen-inducible gene product related to RT p50/p105-NF-kappa B participates in transactivation through a kappa B site RL Mol. Cell. Biol. 12:685-695 (1992). RN [10] RA Mercurio F., Didonato J. A., Rosette C., Karin M. RT p105 and p98 precursor proteins play an active role RT in NF-kappaB-mediated signal transduction RL Genes Dev. 7:705-718 (1993). RN [11] RA Scheinman R. I., Beg A. A., A. S. Baldwin jr. RT NF-kappaB p100 (Lyt-10) is a component of H2TF1 and RT can function as an IkappaB-like molecule RL Mol. Cell. Biol. 13:6089-6101 (1993). RN [12] RA Neri A., Chang C.-C., Lombardi L., Salina M., Corradini RA P., Maiolo A. T., Chaganti R. S. K., Dalla-Favera R. RT B cell lymphoma-associated chromosomal translocation RT involves candidate oncogene lyt-10, homologous to NF-kappaB p50 RL Cell 67:1075-1087 (1991). RN [13] RA Mauxion F., Sen R. RT Alteration of a Single Nucleotide Allows Efficient RT Binding of H2TF1/KBF1 to the Immunoglobulin k Enhancer B Motif RL Mol. Cell. Biol. 9:3548-3552 (1989). RN [14] RA Zhang W. W., Zhang L.-X., Busch R. K., Farres J., Busch H. RT Purification and characterization of a DNA-binding RT heterodimer of 52 and 100 kDa from HeLa cells RL J. Biochem. 290:267-272 (1993). XX // AC T00395 XX ID T00395 XX DT 02.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Hb XX SY Hunchback; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.2.2. XX SZ 758 AA XX SQ MQNWETTATTNYEQHNAWYNSMFAANIKQEPGHHLDGNSVASSPRQSPIPSTNHLEQFLK SQ QQQQQLQQQPMDTLCAMTPSPSQNDQNSLQHYDANLQQQLLQQQQYQQHFQAAQQQHHHH SQ HHLMGGFNPLTPPGLPNPMQHFYGGNLRPSPQPTPTSASTIAPVAVATGSSEKLQALTPP SQ MDVTPPKSPAKSSQSNIEPEKEHDQMSNSSEDMKYMAESEDDDTNIRMPIYNSHGKMKNY SQ KCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCD SQ KCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPGMVLDEDGT SQ PNPSLVIDVYGTRRGPKSKNGGPIASGGSGSGSRKSNVAAVAPQQQQSQPAQPVATSQLS SQ AALQGFPLVQGNSAPPAASPVLPLPASPAKSVASVEQTPSLPSPANLLPPLASLLQQNRN SQ MAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQNQQQSDNQEEEQDDEYERKSVDS SQ AMDLSQGTPVKEDEQQQQPQQPLAMNLKVEEEATPLMSSSNASRRKGRVLKLDTLLQLRS SQ EAMTSPEQLKVPSTPMPTASSPIAGRKPMPEEHCSGTSSADESMETAHVPQANTSASSTA SQ SSSGNSSNASSNSNGNSSSNSSSNGTTSAVAAPPSGTPAAAGAIYECKYCDIFFKDAVLY SQ TIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAHS XX SC SwissProt #P05084 XX SF 4+2 zinc finger motifs XX FF gap gene; FF regulates Krueppel; FF activates eve stripe 2 element; FF anterior suppression of Ubx through bx region enhancer (BRE); FF activator of engrailed XX MX M00022; I$HB_01 XX BS R03022; DROME$EN_11; Quality: 6; fruit fly, Drosophila melanogaster BS R03023; DROME$EN_12; Quality: 6; fruit fly, Drosophila melanogaster BS R02496; DROME$EVE_25; Quality: 6; fruit fly, Drosophila melanogaster BS R02500; DROME$EVE_29; Quality: 6; fruit fly, Drosophila melanogaster BS R02502; DROME$EVE_31; Quality: 6; fruit fly, Drosophila melanogaster BS R02611; DROME$HB_04; Quality: 6; fruit fly, Drosophila melanogaster BS R02612; DROME$HB_05; Quality: 6; fruit fly, Drosophila melanogaster BS R02613; DROME$HB_06; Quality: 6; fruit fly, Drosophila melanogaster BS R02614; DROME$HB_07; Quality: 6; fruit fly, Drosophila melanogaster BS R02615; DROME$HB_08; Quality: 6; fruit fly, Drosophila melanogaster BS R02616; DROME$HB_09; Quality: 6; fruit fly, Drosophila melanogaster BS R02617; DROME$HB_10; Quality: 6; fruit fly, Drosophila melanogaster BS R02618; DROME$HB_11; Quality: 6; fruit fly, Drosophila melanogaster BS R03262; DROME$KR_19; Quality: 6; fruit fly, Drosophila melanogaster BS R03263; DROME$KR_20; Quality: 6; fruit fly, Drosophila melanogaster BS R03264; DROME$KR_21; Quality: 6; fruit fly, Drosophila melanogaster BS R03265; DROME$KR_22; Quality: 6; fruit fly, Drosophila melanogaster BS R03266; DROME$KR_23; Quality: 6; fruit fly, Drosophila melanogaster BS R03267; DROME$KR_24; Quality: 6; fruit fly, Drosophila melanogaster BS R02554; DROME$UBX_17; Quality: 6; fruit fly, Drosophila melanogaster BS R02555; DROME$UBX_18; Quality: 6; fruit fly, Drosophila melanogaster BS R02556; DROME$UBX_19; Quality: 6; fruit fly, Drosophila melanogaster BS R02606; HB$CONS_01; Quality: 6 BS R02607; HB$CONS_02; Quality: 6 XX DR EMBL: Y00274; DMHBG(g). DR SwissProt: P05084; HUNB_DROME. DR PIR: A29253; A29253. DR Flybase: FBgn0001180; hb. XX RN [1] RA Tautz D., Lehmann R., Schnuerch H., Schuh R., Seifert RA E., Kienlin A., Jones K., Jaeckle H. RT Finger protein of novel structure encoded by hunchback, RT a second member of the gap class of Drosophila segmentation genes RL Nature 327:383-389 (1987). RN [2] RA Stanojevic D., Hoey T., Levine M. RT Sequence-specific DNA-binding activities of the gap RT proteins encoded by hunchback and Krueppel in Drosophila RL Nature 341:331-335 (1989). RN [3] RA Treisman J., Desplan C. RT The products of the Drosophila gap genes hunchback RT and Krueppel bind to the hunchback promoters RL Nature 341:335-337 (1989). RN [4] RA Zuo P., Stanojevic D., Colgan J., Han K., Levine M., Manley J. L. RT Activation and repression of transcription by the RT gap proteins hunchback and Krueppel in cultured Drosophila cells RL Genes Dev. 5:254-264 (1991). RN [5] RA Hoch M., Seifert E., Jaeckle H. RT Gene expression mediated by cis-acting sequences of RT the Krueppel gene in response to the Drosophila morphogens RT bicoid and hunchback RL EMBO J. 10:2267-2278 (1991). RN [6] RA Struhl G., Johnson P., Lawrence P. A. RT Control of Drosophila body pattern by the hunchback morphogen gradient RL Cell 69:237-249 (1992). RN [7] RA Zhang C.-C., Bienz M. RT Segmental determination in Drosophila conferred by RT hunchback (hb), a repressor of the homeotic gene Ultrabithorax (Ubx) RL Proc. Natl. Acad. Sci. USA 89:7511-7515 (1992). RN [8] RA Small S., Kraut R., Hoey T., Warrior R., Levine M. RT Transcriptional regulation of a pair-rule stripe in Drosophila RL Genes Dev. 5:827-839 (1991). RN [9] RA Stanojevic D., Small S., Levine M. RT Regulation of segmentation stripe by overlapping activators RT and repressors in the Drosophila embryo RL Science 254:1385-1387 (1991). XX // AC T00396 XX ID T00396 XX DT 16.12.92 (created); ewi. DT 14.02.97 (updated); ewi. XX FA Pax-7 XX SY HuP1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0018; paired-homeo; 3.2.1.0.4. XX SZ 467 AA; 51.0 kDa (cDNA) XX SQ MAALPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIV SQ EMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPRQVATPDVEKKIEE SQ YKRENPGMFSWEIRDRLLKDGHCDRSTVPSGLVSSISRVLRIKFGKKEEEDEADKKEDDG SQ EKKAKHSIDGILGDKGNRLDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFERTH SQ YPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLAAFNHLLPGGFPPTGMPTL SQ PPYQLPDSTYPTTTISQDGGSTVHRPQPLPPSTMHQGGLAAAAAAADTSSAYGARHSFSS SQ YSDSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSAVPPQPQADFSISPLHGGLDSATSIS SQ ASCSQRADSIKPGDSLPTSQAYCPPTYSTTGYSVDPVAGYQYGQYGQ XX SC translated from EMBL/GenBank/DDBJ #Z35141 XX FT 34 164 paired domain FT 215 276 homeo domain FT 293 456 proline-/serine-/threonine-rich region (67/164) FT 340 354 alanine-rich region (9/15) FT 342 467 trans-activation domain [1]; XX SF cooperative binding to palindromic TAAT-sites as homodimer SF or as heterodimer with Pax-3 [1]; XX CP high levels in rhabdomyosarcomas, very low in primary myoblasts [1]; XX FF moderate activator [1]; XX IN T00396; Pax-7; human, Homo sapiens. IN T00679; Pax-3; human, Homo sapiens. XX DR EMBL: X15042; HSHUP1A(g). DR EMBL: X15250; HSHUP1B(g). DR EMBL: X15251; HSHUP1C(g). DR EMBL: Z35141; HSPAX7GE(r). DR SwissProt: P23759; PAX7_HUMAN. DR PIR: S06959; S06959. XX RN [1] RA Schaefer B. W., Czerny T., Bernasconi M., Genni M., Busslinger M. RT Molecular cloning and characterization of a human RT PAX-7 cDNA expressed in normal and neoplastic myocytes RL Nucleic Acids Res. 22:4574-4582 (1994). RN [2] RA Burri M., Tromvoukis Y., Bopp D., Frigerio G., Noll M. RT Conservation of the paired domain in metazoans and RT its structure in three isolated human genes RL EMBO J. 8:1183-1190 (1989). XX // AC T00398 XX ID T00398 XX DT 16.12.92 (created); ewi. DT 17.05.96 (updated); ewi. XX FA Pax-1 XX SY HuP48; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO Pox meso, P29 (Drosophila) XX CL C0017; paired; 3.2.2.0.1. XX SZ >212 AA XX SQ MRRAPLRGSSAPLPTPSQTQAVCPWTPSCLGTHRSPLEVRLGAVPRSAWGPLANPPGVFS SQ PSGSLLSGASAEQTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSH SQ GCVSKILARYNETGSILPGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADG SQ VCDKYNVPSVSSISRILRNKIGSLAQPGPYEA XX SC partial sequence from SwissProt #P15863 XX SF predicted helix-turn-helix motif within the paired domain [1]; XX DR EMBL: X15044; HSHUP48(g). DR SwissProt: P15863; PAX1_HUMAN. DR PIR: S06961; S06961. XX RN [1] RA Burri M., Tromvoukis Y., Bopp D., Frigerio G., Noll M. RT Conservation of the paired domain in metazoans and RT its structure in three isolated human genes RL EMBO J. 8:1183-1190 (1989). XX // AC T00399 XX ID T00399 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA IBF XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX HO EFII, C/EBP XX SZ 40 kDa XX BS R01347; RSV$RSV_07; Quality: 6; RSV, rous sarcoma virus XX RN [1] RA Karnitz L., Poon D., Weil P. A., Chalkley R. RT Purification and Properties of the Rous Sarcoma Virus RT Internal Enhancer Binding Factor RL Mol. Cell. Biol. 9:1929-1939 (1989). XX // AC T00400 XX ID T00400 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA IBP-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SQ MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCC SQ PMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGS SQ PESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIEL SQ YRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIP SQ GSPEIRGDPNCQIYFNVQN XX SC SwissProt #P08833 XX CP (HeLa) XX BS R00919; HS$IFNB_04; Quality: 6; human, Homo sapiens BS R01061; MOUSE$M1H2KB_09; Quality: 6; mouse, Mus musculus XX DR EMBL: Y00856; HSIBP1R(r). DR EMBL: M59316; HSIGFBP1(g). DR SwissProt: P08833; IBP1_HUMAN. DR PIR: A27694; A27694. DR PIR: IOHU1; IOHU1. DR PIR: S01159; S01159. XX RN [1] RA Blanar M. A., Baldwin Jr. A. S., Flavell R. A., Sharp P. A. RT A gamma-interferon-induced factor that binds the interferon RT response sequence of the MHC class I gene, H-2Kb RL EMBO J. 8:1139-1144 (1989). XX // AC T00401 XX ID T00401 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA ICP4 XX SY I10X protein; Vmw175; alpha4 protein; XX OS HSV-1, herpes simplex virus type 1 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX SZ 2 x 170 kDa XX SQ MASQRSDFAPDLYDFIESNDFGEDPLIRAASAAEEGFTQPAAPDLLYGSQNMFGVDDAPL SQ STPAVVIPPPSPTPEPRGGKAKRSPSAAGSGGPPTPAAAAQPASPAPSPAPGLAAMLKMV SQ HSSVAPGNGRRATGSSSPGGGDAADPVALDSDTETCPGSPQPEFPSSASPGGGSPAPRVR SQ SISISSSSSSSSSMDEDDQADGAGASSSSSSSSDDSDSDEGGEEETPRPRHSQNAAKTPS SQ AAGSPGPSSGGDRPAAGAATPKSCRSGAASPGAPAPAPASAPAPSRPGGGLLPPGARILE SQ YLEGVREANLAKTLERPEPPAGMASPPGRSPHRLPKDQRPKSALAGASKRKRANPRPIPQ SQ TQTQAPAEEAPQTAVWDLLDMNSSQATGAAAAAASAPAAASCAPGVYQREPLLTPSGDPW SQ PGSDPPPMGRVRYGGTGDSRDGLWDDPEIVLAASRYAEAQAPVPVFVPEMGDSTKQYNAL SQ VRMVFESREAMSWLQNSKLSGQDQNLAQFCQKFIHAPRGHGSFITGSVANPLPHIGDAMA SQ AGNALWALPHAAASVAMSRRYDRTQKSFILQSLRRAYADMAYPRDEAGRPDSLAAVAGYP SQ AQAAAAAASQQQPEAPAPSVRVREAYTRVCAALGPRRKAAAAAAAPGTRAPRPSAFRLRE SQ LGDACVLACQAVFEALLRLRGGASAVPGLDPSEIPSPACPPEALCSNPAGLETAALSLYE SQ LRDLVERARLLGDSDPTHRLGSDELRLAVRAVLVVARTVAPLVRYNAEGARARASAWTVT SQ QAVFSIPSLVGGMLGEAVSLLAPPTRSQQPSSSSPGGEPFSGSAAAEGSLQTLPPLWPTV SQ PGKQSATVPSSHSQSPQHSQSGGGAGATTATCCRATQTNARSRGQQHQPQKARSPQAAAS SQ PAHLSQEAMPGSSSDDRAIHGRPRGKSGKRRSEPLEPAAQAGASASFSSSARGYDPSGPV SQ DSPPAPKRRVATPGHQAPRALGPMPAEGPDRRGGFRRVPRGDCHTPRPSDAACAAYCPPE SQ LVAELIDNQLFPEAWRPALTFDPQALATIAARCSGPPARDGARFGELAASGPLRRRAAWM SQ HQIPDPEDVKVVVLYSPLQDEDLLGGLPASRPGGSRREPLWSDLKGGLSALLAALGNRIL SQ TKRSHAWAGNWTGAPDVSALNAQGVLLLSTGDLAFTGCVEYLCLRLGSARRKLLVLDAVS SQ TEDWPQDGPAISQYHIYMRAALTPRVACAVRWPRERHLSRAVLTSSTLFGPGLFARAEAA SQ FARLYPDSAPLRLCRSSNVAYTVDTRAGERTRVPLAPREYRQRVLPDYDGCKDMRAQAEG SQ LGFHDPDFEEGAAQSHRAANRWGLGAWLRPVYLACGRRGAGAVEPSELLIPELLSEFCRV SQ ALLEPDAEAEPLVLPITEAPRRRAPRVDWEPGFGSRSTSVLHMGATELCLPEPDDELEID SQ GAGDVELVVEHPGPSPGVAQALRRAPIKIEVVSDDEDGGDWCNPYLS XX SC SwissProt #P28925 XX FT 276 523 protein-protein interactions (dimers) XX SF phosphorylation XX IN T00401; ICP4; HSV-1, herpes simplex virus type 1. XX BS R02851; HSV$G38_01; Quality: 6; HSV-1, herpes simplex virus type 1 BS R02930; HSV$GD_01; Quality: 6; HSV-1, herpes simplex virus type 1 BS R02931; HSV$GD_02; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00783; HSV1$ICP_01; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00784; HSV1$ICP_02; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00785; HSV1$ICP_03; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00786; HSV1$ICP_04; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00811; HSV1$IE1_02; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00813; HSV1$IE3_01; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00822; HSV1$IE3_10; Quality: 6; HSV-1, herpes simplex virus type 1 BS R02017; HSV1$IE3_12; Quality: 6; HSV-1, herpes simplex virus type 1 BS R01695; HSV1$TK_06; Quality: 6; HSV-1, herpes simplex virus type 1 BS R02722; HSV1$TK_10; Quality: 6; HSV-1, herpes simplex virus type 1 BS R02723; HSV1$TK_11; Quality: 6; HSV-1, herpes simplex virus type 1 BS R03705; ICP4$CONS_01; Quality: 6 XX DR EMBL: M86664; HEHSECOMG(g). DR SwissProt: P28925; ICP4_HSVEB. DR PIR: EDBEF6; EDBEF6. XX RN [1] RA Everett R. D., Elliott M., Hope G., Orr A. RT Purification of the DNA binding domain of herpes simplex RT virus type 1 immediate-early protein Vmw175 as a homodimer RT and extensive mutagenesis of its DNA recognition site RL Nucleic Acids Res. 19:4901-4908 (1991). RN [2] RA Morse L. S., Pereira L., Roizman B., Schaffer P. A. RT Anatomy of Herpes Simplex Virus (HSV) DNA RL J. Virol. 26:389-410 (1978). RN [3] RA Papavassilious A. G., Silverstein S. J. RT Characterization of DNA-Protein Complex Formation RT in Nuclear Extracts with a Sequence from the Herpes RT Simplex Virus Thymidine Kinase Gene RL J. Biol. Chem. 265:1648-1657 (1990). RN [4] RA Papavassiliou A. G., Wilcox K. W., Silverstein S. J. RT The interaction of ICP4 with cell/infected-cell factors RT and its state of phosphorylation modulate differential RT recognition of leader sequences in herpes simplex virus DNA RL EMBO J. 10:397-406 (1991). RN [5] RA Michael N., Spector D., Mavromara-Nazos P., Kristie T. M., Roizman B. RT The DNA-binding properties of the major regulatory RT protein alpha4 of herpes simplex viruses RL Science 239:1531 (1988). RN [6] RA Kristie T. M., Roizman B. RT DNA-binding site of major regulatory protein alpha4 RT specifically associated with promoter-regulatory domains RT of alpha genes of herpes simplex virus type 1 RL Proc. Natl. Acad. Sci. USA 83:4700-4704 (1986). RN [7] RA Faber S. W., Wilcox K. W. RT Association of herpes simplex virus regulatory protein RT ICP4 with sequences spanning the ICP4 gene transcription initiation site RL Nucleic Acids Res. 16:555-570 (1988). RN [8] RA Everett R. D., Paterson T., Elliott M. RT The major transcriptional regulatory protein of herpes RT simplex virus type 1 includes a protease resistant DNA binding domain RL Nucleic Acids Res. 18:4579-4585 (1990). XX // AC T00402 XX ID T00402 XX DT 15.10.92 (created); ewi. DT 21.05.97 (updated); ewi. XX FA ICSBP XX SY IFN consensus sequence binding protein; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0022; trp; 3.5.3.0.5. XX SZ 424 AA; 48.2 kDa (cDNA) XX SQ MCDRNGGRRLRQWLIEQIDSSMYPGLIWENDEKTMFRIPWKHAGKQDYNQEVDASIFKAW SQ AVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKC SQ KLGVAPAGCMSEVPEMECGRSEIEELIKEPSVDEYMGMTKRSPSPPEACRSQILPDWWVQ SQ QPSAGLPLVTGYAAYDTHHSAFSQMVISFYYGGKLVGQATTTCLEGCRLSLSQPGLPKLY SQ GPDGLEPVCFPTADTIPSERQRQVTRKLFGHLERGVLLHSNRKGVFVKRLCQGRVFCSGN SQ AVVCKGRPNKLERDEVVQVFDTNQFIRELQQFYATQSRLPDSRVVLCFGEEFPDTVPLRS SQ KLILVQVEQLYARQLVEEAGKSCGAGSLMPALEEPQPDQAFRMFPDICTSHQRPFFRENQ SQ QITV XX SC SwissProt #P23611 XX FT 33 424 repressing fragment [4]; FT 1 121 DNA-binding domain [5], [4]; FT 13 78 tryptophan cluster (W-X14-W-X11-W-X19-W-X17-W) XX SF N-terminal 115 AA have 45% identity with IRF-1, 47% identity with IRF-2 [5]; SF no similarity with IRFs for the C-terminal 309 AA SF direct interaction with either IRF-1 or IRF-2 enhances SF DNA-binding capability [1]; XX CP spleen, thymus [5]; CN brain, liver [5]; XX FF transcriptional repressor, acting through ISREs thus FF being an IRF-1 antagonist [2]; FF also inhibiting binding of ISGF3 to ISREs [1]; FF mRNA induced by IFN-gamma, not by IFN-alpha/beta [5]; FF transcription is activated through a STAT-like element [3]; XX IN T00422; IRF-1; mouse, Mus musculus. IN T00425; IRF-2; mouse, Mus musculus. XX BS R00002; HS$6-16_02; Quality: 6; human, Homo sapiens BS R00423; HS$CBF_01; Quality: 6; human, Homo sapiens BS R00919; HS$IFNB_04; Quality: 6; human, Homo sapiens BS R00927; HS$IFNB_12; Quality: 6; human, Homo sapiens BS R00950; HS$ISG54_01; Quality: 6; human, Homo sapiens BS R00163; HS$OAS_04; Quality: 6; human, Homo sapiens BS R01094; MOUSE$B2MG_01; Quality: 6; mouse, Mus musculus BS R01051; MOUSE$M1H2DD_02; Quality: 6; mouse, Mus musculus BS R01061; MOUSE$M1H2KB_09; Quality: 6; mouse, Mus musculus BS R01066; MOUSE$M1H2LD_04; Quality: 6; mouse, Mus musculus XX DR EMBL: M32489; MMICSBP(r). DR SwissProt: P23611; ICSB_MOUSE. DR PIR: A35861; A35861. XX RN [1] RA Bovolenta C., Driggers P. H., Marks M. S., Medin J. RA A., Politis A. D., Vogel S. N., Levy D. E., Sakaguchi RA K., Appella E., Coligan J. E., Ozato K. RT Molecular interactions between interferon consensus RT sequence binding protein and members of the interferon RT regulatory factor family RL Proc. Natl. Acad. Sci. USA 91:5046-5050 (1994). RN [2] RA Nelson N., Marks M. S., Driggers P. H., Ozato K. RT Interferon consensus sequence-binding protein, a member RT of the interferon regulatory factor family, suppresses RT interferon-induced gene transcription RL Mol. Cell. Biol. 13:588-599 (1993). RN [3] RA Kanno Y., Kozak C. A., Schindler C., Driggers P. H., RA Ennist D. L., Gleason S. L., Darnell J. E., Ozato K. RT The genomic structure of the murine ICSBP gene reveals RT the presence of the gamma-interferon-responsive element, RT to which an ISGF3alpha subunit (or similar) molecule binds RL Mol. Cell. Biol. 13:3951-3963 (1993). RN [4] RA Sharf R., Azriel A., Lejbkowicz F., Winograd S. S., Ehrlich R., Levi B.-Z. RT Functional domain analysis of interferon consensus RT sequence binding protein (ICSBP) and its association RT with interferon regulatory factors RL J. Biol. Chem. 270:13063-13069 (1995). RN [5] RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., RA Marks M. S., Levi B.-Z., Flanagan J. R., Appella E., Ozato K. RT An interferon gamma-regulated protein that binds the RT interferon-inducible enhancer element of major histocompatibility RT complex class I genes RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990). XX // AC T00403 XX ID T00403 XX DT 22.10.92 (created); ewi. DT 06.05.97 (updated); ewi. XX FA Id1 XX SY Id; inhibitor of DNA-binding 1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0011; HLH; 1.2.8.0.2. XX SZ 148 AA; 15.6 kDa (cDNA), 14 kDa, 18 kDa (SDS) XX SQ MKVASGSAAAAAGPSCSLKAGRTAGEVVLGLSEQSVAISRCAGTRLPALLDEQQVNVLLY SQ DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVGTTGGRGLPVRA SQ PLSTLNGEISALAAEAACVPADDRILCR XX SC SwissProt #P20067 XX FT 59 99 helix-loop-helix domain XX SF no basic (=DNA-binding) domain SF homodimerization (KD = 5.3 uM) and homotetramerization (KD = 0.36 uM) [3]; SF avidly binding to MyoD (KD = 0.7 uM, KD = 0.01 uM) [3]; SF the loop region is mainly responsible for dimerization specificity [6]; XX CP undifferentiated cells XX FF inhibitor of bHLH proteins (e. g. E47, MyoD, not: FF TFE3), inhibits myeloid [2] and erythroid differentiation [11]; FF down-regulated at confluence or differentiation [4], [1], [2]; FF 10-fold lower levels in myotubes than in myoblasts [2]; FF inhibits B cell development [10]; FF but also enhanced transiently upon osteogenic differentiation FF induced by BMP-2 [7]; FF enhanced by glucocorticoids in MC3T3E1 [14]; FF antagonizes growth suppression by E12/E47, involved FF in growth induction by serum growth factors [8]; FF involved in muscle atrophy upon disuse [9]; XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00404; Id2; mouse, Mus musculus. IN T00405; IEBP1; rat, Rattus norvegicus. IN T00432; ITF-1; human, Homo sapiens. IN T00433; ITF-2; human, Homo sapiens. IN T00506; MEF1; mouse, Mus musculus. IN T00521; Myf-5; human, Homo sapiens. IN T00524; MyoD; clawed frog, Xenopus laevis. IN T00525; MyoD; human, Homo sapiens. IN T00526; MyoD; mouse, Mus musculus. IN T00527; MyoD; monkey, Cercopithecus aethiops. IN T00528; myogenin; mouse, Mus musculus. IN T00674; E47; rat, Rattus norvegicus. IN T00675; E12; rat, Rattus norvegicus. IN T01128; MyoD; chick, Gallus gallus. IN T01212; Id2; human, Homo sapiens. IN T01659; m3; mouse, Mus musculus. IN T01787; E12; clawed frog, Xenopus laevis. IN T01788; E47; mouse, Mus musculus. XX DR EMBL: M31885; MMID(r). DR SwissProt: P20067; ID1_MOUSE. DR PIR: A34690; A34690. XX RN [1] RA Wilson R. B., Kiledjian M., Shen C.-P., Benezra R., RA Zwollo P., Dymecki S. M., Desiderio S. V., Kadesch T. RT Repression of immunoglobulin enhancers by the helix-loop-helix RT protein Id: implications for B-lymphoid-cell development RL Mol. Cell. Biol. 11:6185-6191 (1991). RN [2] RA Jen Y., Weintraub H., Benezra R. RT Overexpression of Id protein inhibits the muscle differentiation RT program: in vivo association of Id with E2A proteins RL Genes Dev. 6:1466-1479 (1992). RN [3] RA Fairman R., Beran-Steed R. K., Anthony-Cahill S. J., RA Lear J. D., Stafford III W. F., DeGrado W. F., Benfield P. A., Brenner S. L. RT Multiple oligomeric states regulate the DNA binding RT of helix-loop-helix proteins RL Proc. Natl. Acad. Sci. USA 90:10429-10433 (1993). RN [4] RA Benezra R., Davis R. L., Lockshon D., Turner D. L., Weintraub H. RT The protein Id: a negative regulator of helix-loop-helix RT DNA binding proteins RL Cell 61:49-59 (1990). RN [5] RA Murray S. S., Glackin C. A., Winters K. A., Gazit RA D., Kahn A. J., Murray E. J. RT Expression of helix-loop-helix regulatory genes during RT differentiation of mouse osteoblastic cells RL J. Bone Mineral Res. 7:1131-1138 (1992). RN [6] RA Pesce S., Benezra R. RT The loop region of the helix-loop-helix protein Id1 RT is critical for its dominant negative activity RL Mol. Cell. Biol. 13:7874-7880 (1993). RN [7] RA Ogata T., Wozney J. M., Benezra R., Noda M. RT Bone morphogenetic protein 2 transiently enhances RT expression of a gene, Id (inhibitor of differentiation), RT encoding a helix-loop-helix molecule in osteoblast-like cells RL Proc. Natl. Acad. Sci. USA 90:9219-9222 (1993). RN [8] RA Barone M. V., Pepperkok R., Peverali F. A., Philipson L. RT Id proteins control growth induction in mammalian cells RL Proc. Natl. Acad. Sci. USA 91:4985-4988 (1994). RN [9] RA Gundersen K., Merlie J. P. RT Id-1 as a possible transcriptional mediator of muscle disuse atrophy RL Proc. Natl. Acad. Sci. USA 91:3647-3651 (1994). RN [10] RA Sun X.-H. RT Constitutive expression of the Id1 gene impairs mouse B cell development RL Cell 79:893-900 (1994). RN [11] RA Lister J., Forrester W. C., Baron M. H. RT Inhibition of an erythroid differentiation switch RT by the helix-loop-helix protein Id1 RL J. Biol. Chem. 270:17939-17946 (1995). RN [12] RA Pongubala J. M. R., Atchison M. L. RT Functional characterization of the developmentally RT controlled immunoglobulin kappa 3' enhancer: regulation RT by Id, a repressor of helix-loop-helix transcription factors RL Mol. Cell. Biol. 11:1040-1047 (1991). RN [13] RA Sun X.-H., Copeland N. G., Jenkins N. A., Baltimore D. RT Id proteins Id1 and Id2 selectively inhibit DNA binding RT by one class of helix-loop-helix proteins RL Mol. Cell. Biol. 11:5603-5611 (1991). RN [14] RA Ogata T., Noda M. RT Expression of Id, a negative regulator of helix-loop-helix RT DNA binding proteins, is down-regulated at confluence RT and enhanced by dexamethasone in a mouse osteoblastic cell line, MC3T3E1 RL Biochem. Biophys. Res. Commun. 180:1194-1199 (1991). XX // AC T00404 XX ID T00404 XX DT 22.10.92 (created); ewi. DT 14.05.96 (updated); ewi. XX FA Id2 XX SY Id-2; inhibitor of DNA-binding 2; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0011; HLH; 1.2.8.0.3. XX SZ 134 AA; 15.0 kDa (cDNA) XX SQ MKAFSPVXSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVT SQ KMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTRLTTLNTDISILSLQASEF SQ PSELMSNDSKVLCG XX SC SwissProt #P41136 XX FT 36 76 helix-loop-helix domain XX SF no basic (=DNA-binding) domain SF heterodimerizes with several bHLH factors, but not SF with USF, TFE-3, AP-4, or Id1 [4]; XX CP undifferentiated cells XX FF inhibits bHLH proteins and myeloid differentiation; FF promotes cell proliferation [2]; FF in different neuronal cell lines, Id2 may increase, FF decrease, or remain constant during differentiation [3]; XX IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00405; IEBP1; rat, Rattus norvegicus. IN T00524; MyoD; clawed frog, Xenopus laevis. IN T00525; MyoD; human, Homo sapiens. IN T00526; MyoD; mouse, Mus musculus. IN T00527; MyoD; monkey, Cercopithecus aethiops. IN T00674; E47; rat, Rattus norvegicus. IN T01128; MyoD; chick, Gallus gallus. IN T01659; m3; mouse, Mus musculus. IN T01788; E47; mouse, Mus musculus. XX DR EMBL: U10994; MM10994(g). DR EMBL: M69293; MMID2A(r). DR SwissProt: P41136; ID2_MOUSE. XX RN [1] RA Staudinger J., Perry M., Elledge S. J., Olson E. N. RT Interactions among vertebrate helix-loop-helix proteins RT in yeast using the two-hybrid system RL J. Biol. Chem. 268:4608-4611 (1993). RN [2] RA Barone M. V., Pepperkok R., Peverali F. A., Philipson L. RT Id proteins control growth induction in mammalian cells RL Proc. Natl. Acad. Sci. USA 91:4985-4988 (1994). RN [3] RA Neuman T., Keen A., Zuber M. X., Kristjansson G. I., Gruss P., Nornes H. O. RT Neuronal expression of regulatory helix-loop-helix factor Id2 gene in mouse RL Develop. Biol. 160:186-195 (1993). RN [4] RA Sun X.-H., Copeland N. G., Jenkins N. A., Baltimore D. RT Id proteins Id1 and Id2 selectively inhibit DNA binding RT by one class of helix-loop-helix proteins RL Mol. Cell. Biol. 11:5603-5611 (1991). XX // AC T00405 XX ID T00405 XX DT 22.10.92 (created); ewi. DT 30.05.95 (updated); ewi. XX FA IEBP1 XX SY E47 (human); IEBP-1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; 1.2.1.0.1.2. XX IN T00003; AS-C T3; fruit fly, Drosophila melanogaster. IN T00204; E12; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00404; Id2; mouse, Mus musculus. IN T00506; MEF1; mouse, Mus musculus. IN T00526; MyoD; mouse, Mus musculus. IN T00790; Tal-1; human, Homo sapiens. IN T01212; Id2; human, Homo sapiens. IN T01606; Id1.25; rat, Rattus norvegicus. IN T01807; Id1; rat, Rattus norvegicus. XX RN [1] RA Shibasaki Y., Sakura H., Takaku F., Kasuga M. RT Insulin enhancer binding protein has helix-loop-helix structure RL Biochem. Biophys. Res. Commun. 170:314-321 (1990). XX // AC T00406 XX ID T00406 XX DT 15.10.92 (created); ewi. DT 06.05.96 (updated); ewi. XX FA INSAF XX SY IEF-1; IEF1; insulin activator factor; XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX CL C0010; bHLH; 1.2.4.5.1. XX SF reactive with anti-HLH antibodies XX CP pancreatic beta cells XX BS R02182; IAF$CONS; Quality: 6 BS R00850; MOUSE$IGH_16; Quality: 6; mouse, Mus musculus BS R00909; RAT$INS1_05; Quality: 6; rat, Rattus norvegicus BS R00900; RAT$INS_03; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Leshkovitz D., Walker M. D. RT Extinction of insulin gene expression in hybrids between RT beta cells and fibroblasts is accompanied by loss RT of the putative beta-cell-specific transcription factor IEF1 RL Mol. Cell. Biol. 11:1547-1552 (1991). RN [2] RA Aronheim A., Ohlsson H., Park C. W., Edlund T., Walker M. D. RT Distribution and characterization of helix-loop-helix RT enhancer-binding proteins from pancreatic beta cells and lymphocytes RL Nucleic Acids Res. 19:3893-3899 (1991). XX // AC T00407 XX ID T00407 XX DT 15.10.92 (created); ewi. XX FA IEFga XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 43-68 kDa (SDS-cl) XX BS R01837; HSV1$IE3_11; Quality: 6; HSV-1, herpes simplex virus type 1 XX RN [1] RA LaMarco K. L., McKnight S. L. RT Purification of a set of cellular polypeptides that RT bind to the purine-rich cis-regulatory element of RT herpes simplex virus immediate early genes RL Genes Dev. 3:1372-1383 (1989). XX // AC T00408 XX ID T00408 XX DT 26.01.93 (created); ewi. XX FA IF1 XX SY IF-1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX FF transcriptional inhibitor XX BS R02871; MOUSE$A11COL_02; Quality: 6; mouse, Mus musculus BS R02872; MOUSE$A11COL_03; Quality: 6; mouse, Mus musculus XX RN [1] RA Karsenty G., de Crombrugghe B. RT Two different negative and one positive regulatory RT factors interact with a short promoter segment of RT the alpha1(I) collagen gene RL J. Biol. Chem. 265:9934-9942 (1990). XX // AC T00409 XX ID T00409 XX DT 26.01.93 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA IF2 XX SY IF-2; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SF zinc-dependent XX FF transcriptional inhibitor XX BS R00228; MOUSE$A11COL_01; Quality: 6; mouse, Mus musculus BS R02873; MOUSE$A11COL_04; Quality: 6; mouse, Mus musculus XX RN [1] RA Karsenty G., de Crombrugghe B. RT Two different negative and one positive regulatory RT factors interact with a short promoter segment of RT the alpha1(I) collagen gene RL J. Biol. Chem. 265:9934-9942 (1990). XX // AC T00410 XX ID T00410 XX DT 15.10.92 (created); ewi. XX FA IgPE-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00849; MOUSE$IGH_15; Quality: 6; mouse, Mus musculus BS R01153; MSV$MSV_01; Quality: 6; MSV, murine sarcoma virus XX RN [1] RA Schlokat U., Bohmann D., Schoeler H., Gruss P. RT Nuclear factors binding specific sequences within RT the immunoglobulin enhancer interact differentially RT with other enhancer elements RL EMBO J. 5:3251-3258 (1986). XX // AC T00411 XX ID T00411 XX DT 15.10.92 (created); ewi. XX FA IgPE-2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00858; MOUSE$IGH_24; Quality: 6; mouse, Mus musculus XX RN [1] RA Schlokat U., Bohmann D., Schoeler H., Gruss P. RT Nuclear factors binding specific sequences within RT the immunoglobulin enhancer interact differentially RT with other enhancer elements RL EMBO J. 5:3251-3258 (1986). XX // AC T00412 XX ID T00412 XX DT 15.10.92 (created); ewi. XX FA IgPE-3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00868; MOUSE$IGH_34; Quality: 6; mouse, Mus musculus XX RN [1] RA Schlokat U., Bohmann D., Schoeler H., Gruss P. RT Nuclear factors binding specific sequences within RT the immunoglobulin enhancer interact differentially RT with other enhancer elements RL EMBO J. 5:3251-3258 (1986). XX // AC T00413 XX ID T00413 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA IkappaB XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 4.1.2.0.1. XX SZ 60-70 kDa (GF); 35 kDa (SDS) XX SF phosphorylation XX IN T00595; RelA; mouse, Mus musculus. XX RN [1] RA Ghosh S., Baltimore D. RT Activation in vitro of NF-kappaB by phosphorylation of its inhibitor IkappaB RL Nature 344:678-682 (1990). RN [2] RA Baeuerle P., Baltimore D. RT A 65-kD subunit of active NF-kappaB is required for RT inhibition of NF-kappaB by IkappaB RL Genes Dev. 3:1689-1698 (1989). XX // AC T00414 XX ID T00414 XX DT 15.10.92 (created); ewi. DT 05.11.96 (updated); ewi. XX FA IkappaB-beta XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 4.1.2.0.2. XX SZ 43 kDa (SDS) [2]; XX FF inhibitor of NF-kappaB, c-Rel and v-Rel [2]; FF dissociates NF-kappaB/DNA complexes [2]; FF XX IN T00587; NF-kappaB; rat, Rattus norvegicus. IN T00588; NF-kappaB; mouse, Mus musculus. IN T00590; NF-kappaB; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T00595; RelA; mouse, Mus musculus. IN T01924; NF-kappaB1 precursor; mouse, Mus musculus. IN T01925; NF-kappaB1 precursor; human, Homo sapiens. XX RN [1] RA Ghosh S., Baltimore D. RT Activation in vitro of NF-kappaB by phosphorylation of its inhibitor IkappaB RL Nature 344:678-682 (1990). RN [2] RA Zabel U., Bauerle P. A. RT Purified human IkappaB can rapidly dissociate the RT complex of the NF-kappaB transcription factor with its cognate DNA RL Cell 61:255-265 (1990). XX // AC T00415 XX ID T00415 XX DT 15.10.92 (created); ewi. DT 01.11.94 (updated); ewi. XX FA IkappaB-alpha XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 4.1.2.0.1. XX SZ 35-37 kDa XX FF inhibitor of NF-kappaB, not of c-Rel or v-Rel XX // AC T00416 XX ID T00416 XX DT 15.10.92 (created); ewi. DT 01.11.94 (updated); ewi. XX FA IkappaB-beta XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL ; ; 4.1.2.0.2. XX SZ 40 kDa (SDS) XX FF inhibitor of NF-kappaB, c-Rel and v-Rel XX IN T00168; c-Rel; human, Homo sapiens. IN T00169; c-Rel; mouse, Mus musculus. IN T00587; NF-kappaB; rat, Rattus norvegicus. IN T00588; NF-kappaB; mouse, Mus musculus. IN T00590; NF-kappaB; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T00595; RelA; mouse, Mus musculus. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T01154; c-Rel; chick, Gallus gallus. IN T01924; NF-kappaB1 precursor; mouse, Mus musculus. IN T01925; NF-kappaB1 precursor; human, Homo sapiens. XX RN [1] RA Kerr L. D., Inoue J.-I., Davis N., Link E., Baeuerle RA P. A., Bose H. R., jr. -, Verma I. M. RT The Rel-associated pp40 protein prevents DNA binding RT of Rel and NF-kappaB: relationship with IkappaBbeta RT and regulation by phosphorylation RL Genes Dev. 5:1464-1476 (1991). RN [2] RA Davis N., Ghosh S., Simmons D. L., Tempst P., Liou RA H.-C., Baltimore D., Bose H. R., jr. - RT Rel-associated pp40: An inhibitor of the Rel family of transcription factors RL Science 253:1268-1271 (1991). XX // AC T00417 XX ID T00417 XX DT 23.11.92 (created); ewi. XX FA Il-1 RF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF interleukin-1 induced; FF related to, but distinct from C/EBP XX BS R02468; HS$CC3_01; Quality: 6; human, Homo sapiens XX RN [1] RA Wilson D. R., Juan T. S.-C., Wilde M. D., Fey G. H., Darlington G. J. RT A 58-base-pair region of the human C3 gene confers RT synergistic inducibility by interleukin-1 and interleukin-6 RL Mol. Cell. Biol. 10:6181-6191 (1990). XX // AC T00418 XX ID T00418 XX DT 23.11.92 (created); ewi. XX FA Il-6 RF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF interleukin-6 induced XX BS R02468; HS$CC3_01; Quality: 6; human, Homo sapiens XX RN [1] RA Wilson D. R., Juan T. S.-C., Wilde M. D., Fey G. H., Darlington G. J. RT A 58-base-pair region of the human C3 gene confers RT synergistic inducibility by interleukin-1 and interleukin-6 RL Mol. Cell. Biol. 10:6181-6191 (1990). XX // AC T00419 XX ID T00419 XX DT 15.10.92 (created); ewi. XX FA ILRF-A XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX RN [1] RA Shimizu H., Mitomo K., Watanabe T., Okamoto S., Yamamoto K.-I. RT Involvment of a NK-kB-Like Transcription Factor in RT the Activation of the Interleukin-6 Gene by Inflammatory Lymphokines RL Mol. Cell. Biol. 10:561-568 (1990). XX // AC T00420 XX ID T00420 XX DT 26.01.93 (created); hse. DT 16.03.94 (updated); hwi. XX FA IRBP XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 110 kDa (SDS) XX FF acts on Jun family gene promoters XX BS R02185; IRBP$CONS; Quality: 6 XX RN [1] RA de Groot R. P., Auwerx J., Karperien M., Staels B., Kruijer W. RT Activation of junB by PKC and PKA signal transduction RT through a novel cis-acting element RL Nucleic Acids Res. 19:775-781 (1991). XX // AC T00421 XX ID T00421 XX DT 15.10.92 (created); ewi. DT 04.03.97 (updated); ewi. XX FA IREBF-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0009; ZIP; 1.1.6.0.4. XX SZ 311 AA; 35.5 kDa (cDNA) XX SQ MMERISKKQIDTSERFYMIPKALFENNVYATMMLEAKVAYSILKDRFKLSLKNNWVDAEG SQ NVFLIYKNKDLQKILGVGEKKVISIKKELTKFDLLEEERQGLNRPNKLYIGNLDTDKTTI SQ GDAKPLGDKDHINRQVQNCQNDRSGTGKMTGQELSNRQSSDTEYSDTELSNTETNNHFDD SQ EIIDVNSKSISNRTIEEDVIKCGELIGSNTQIRGLVQKHFGDMLVEDPKMMVEIIETLIK SQ TFNSLETKIDQGNQSLVILANKLGRDEAVLFILNKVVANQLEYMRDNLVDYAHFAAYFAK SQ GLSNRVNLIIY XX SC SwissProt #P22560 XX FT 46 83 region of similarity with GAL4 DNA-binding domain [1]; FT 161 184 acidic region (9/24) FT 256 284 potential leucine ziper (L3VM) FT 281 309 potential leucine zipper (L2ALI) XX SF the whole C-terminal part (233-311) may constitute SF an amphiphilic alpha-helix [1]; XX BS R02184; IREBF1$CONS; Quality: 6 BS R00164; MOUSE$OAS_05; Quality: 6; mouse, Mus musculus XX DR EMBL: M55290; MMIFN1AA(r). DR SwissProt: P22560; RBF1_MOUSE. DR PIR: A38558; A38558. XX RN [1] RA Yan C., Tamm I. RT Molecular cloning and characterization of interferon RT alpha/beta response element binding factors of the RT murine (2'-5')oligoadenylate synthetase ME-12 gene RL Proc. Natl. Acad. Sci. USA 88:144-148 (1991). XX // AC T00422 XX ID T00422 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA IRF-1 XX SY ISGF2; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0022; trp; 3.5.3.0.1. XX SZ 329 AA; 37.3 kDa (cDNA) XX SQ MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAI SQ HTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTRNQR SQ KERKSKSSRDTKSKTKRKLCGDVSPDTFSDGLSSSTLPDDHSSYTTQGYLGQDLDMERDI SQ TPALSPCVVSSSLSEWHMQMDIIPDSTTDLYNLQVSPMPSTSEAATDEDEEGKIAEDLMK SQ LFEQSEWQPTHIDGKGYLLNEPGTQLSSVYGDFSCKEEPEIDSPRGDIGIGIQHVFTEMK SQ NMDSIMWMDSLLGNSVRLPPSIQAIPCAP XX SC SwissProt #P15314 XX FT 11 77 tryptophan cluster (W-X14-W-X11-W-X19-W-X18-W) FT 125 166 serine-/threonine-rich region (17/42) FT 223 246 acidic region (10/24) XX FF positive regulator of interferon-beta expression; FF binds with the N-terminal part to interferon- and FF to virus-inducible enhancer elements [2]; FF same DNA binding specificity as IRF-2; FF the C-terminal part comprises a trans-activating domain [7]; FF inducible by IL-6 [4]; FF immediate-early gene product [3] of differentiated cells [11], [8]; FF required for normal thymocyte development [6]; FF required for NO synthase induction in macrophages [9]; XX IN T00402; ICSBP; mouse, Mus musculus. XX MX M00062; V$IRF1_01 XX BS R04222; AS$IRF_01; Quality: 3 BS R00915; HS$IFNA1_01; Quality: 1; human, Homo sapiens BS R00917; HS$IFNB_02; Quality: 1; human, Homo sapiens BS R00919; HS$IFNB_04; Quality: 1; human, Homo sapiens BS R00950; HS$ISG54_01; Quality: 2; human, Homo sapiens BS R02187; ISGF2$CONS; Quality: 6 BS R03126; MOUSE$IL7R_01; Quality: 1; mouse, Mus musculus BS R01051; MOUSE$M1H2DD_02; Quality: 1; mouse, Mus musculus BS R01061; MOUSE$M1H2KB_09; Quality: 4; mouse, Mus musculus XX DR EMBL: M21065; MMIRF1B(r). DR SwissProt: P15314; IRF1_MOUSE. DR PIR: A31595; A31595. XX RN [1] RA Watanabe N., Sakakibara J., Hovanessian A. G., Taniguchi T., Fujita T. RT Activation of IFN-beta element by IRF-1 requires a RT post-translational event in addition to IRF-1 synthesis RL Nucleic Acids Res. 19:4421-4428 (1991). RN [2] RA Fujita T., Sakakibara J., Sudo Y., Miyamoto M., Kimura Y., Taniguchi T. RT Evidence for a nuclear factor(s), IRF-1, mediating RT induction and silencing properties to human IFN-beta RT gene regulatory elements RL EMBO J. 11:3397-3405 (1988). RN [3] RA Miyamoto M., Fujita T., Kimura Y., Maruyama M., Harada RA H., Sudo Y., Miyata T., Taniguchi T. RT Regulated Expression of a Gene Encoding a Nuclear RT Factor, IRF-1, That Specifically Binds to IFN-beta Gene Regulatory Elements RL Cell 54:903-913 (1988). RN [4] RA Harroch S., Revel M., Chebath J. RT Induction by interleukin-6 of interferon regulatory RT factor 1 (IRF-1) gene expression through the palindromic RT interferon response element pIRE and cell type-dependent RT control of IRF-1 binding to DNA RL EMBO J. 13:1942-1949 (1994). RN [5] RA Tanaka N., Kawakami T., Taniguchi T. RT Recognition DNA sequences of interferon regulatory RT factor 1 (IRF-1) and IRF-2, regulators of cell growth RT and the interferon system RL Mol. Cell. Biol. 13:4531-4538 (1993). RN [6] RA Matsuyama T., Kimura T., Kitagawa M., Pfeffer K., RA Kawakami T., Watanabe N., Kuendig T. M., Amakawa R., RA Kishihara K., Wakeham A., Potter J., Furlonger C. RA L., Narendran A., Suzuki H., Ohashi P. S., Paige C. RA J., Taniguchi T., Mak T. W. RT Targeted disruption of IRF-1 or IRF-2 results in abnormal RT type I IFN gene induction and aberrant lymphocyte developement RL Cell 75:83-97 (1993). RN [7] RA Fujita T., Kimura Y., Miyamoto M., Barsoumian E. L., Taniguchi T. RT Induction of endogenous IFN-alpha and IFN-beta genes RT by a regulatory transcription factor, IRF-1 RL Nature 337:270-272 (1989). RN [8] RA Ruffner H., Reis L. F. L., Naef D., Weissmann C. RT Induction of type I interferon genes and interferon-inducible RT genes in embryonal stem cells devoid of interferon regulatory factor 1 RL Proc. Natl. Acad. Sci. USA 90:11503-11507 (1993). RN [9] RA Kamijo R., Harada H., Matsuyama T., Bosland M., Gerecitano RA J., Shapiro D., Le J., Koh S. I., Kimura T., Green RA S. J., Mak T. W., Vilcek T. Taniguchi. J. RT Requirement for transcription factor IRF-1 in NO synthase RT induction in macrophages RL Science 263:1612-1615 (1994). RN [10] RA Pleimann C. M., Gimpel S. D., Park L. S., Harada H., RA Taniguchi T., Ziegler S. F. RT Organization of the murine and human interleukin-7 RT receptor genes: two mRNAs generated by differential RT splicing and presence of a type I-interferon-inducible promoter RL Mol. Cell. Biol. 11:3052-3059 (1991). RN [11] RA Harada H., Willison K., Sakakibara J., Miyamoto M., Fujita T., Taniguchi T. RT Absence of the type I IFN system in EC cells: transcriptional RT activator (ITF-1) and repressor (IRF-2) genes are developmentally regulated RL Cell 63:303-312 (1990). XX // AC T00423 XX ID T00423 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA IRF-1 XX SY ISGF2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0022; trp; 3.5.3.0.1. XX SZ 325 AA; 36.5 kDa (cDNA), 37 kDa (SDS) XX SQ MPITWMRMRPWLEMQINSNQIPGLIWINKEEMILEIPWKHAAKHGWDINKDACLFRSWAI SQ HTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKNQR SQ KERKSKSSRDAKSKAKRKSCGDSSPDTFSDGLSSSTLPDDHSSYTVPGYMQDLEVEQALT SQ PALSPCAVSSTLPDWHIPVEVVPDSTSDLYNFQVSPMPSISEATTDEDEEGKLPEDIMKL SQ LEQSEWQPTNVDGKGYLLNEPGVQPTSVYGDFSCKEEPEIDSPGGDIGLSLQRVFTDLKN SQ MDATWLDSLLTPVRLPSIQAIPCAP XX SC SwissProt #P10914 XX FT 11 77 tryptophan cluster (W-X14-W-X11-W-X19-W-X18-W) FT 125 165 serine-/threonine-rich region (16/41) FT 222 245 acidic region (10/24) XX SF M-form appears as 56-kDa protein XX FF positive regulator of interferon-beta and IFN-induced genes [5]; FF tumor suppressor antagonizing IRF-2 transforming potential [9]; FF deleted in some leukemias and myelodysplasias showing FF cytogenetic abnormalities of chromosome 5 [10]; FF M- and G-forms of ISGF2 are generated by posttranscriptional modifications; FF same DNA binding specificity as IRF-2; FF inducible by IL-6 [3], IFN-gamma [6], weakly by IFN-alpha, FF through an inverted GAAANN repeat, no autoregulation observed [6]; FF activated by ISGF3 and thus being a target gene of STAT1 [7], [11]; FF induction requires de novo protein synthesis XX MX M00062; V$IRF1_01 XX BS R04222; AS$IRF_01; Quality: 3 BS R03274; AS$ISRE_02; Quality: 6 BS R02897; HS$GBP_01; Quality: 5; human, Homo sapiens BS R00919; HS$IFNB_04; Quality: 1; human, Homo sapiens BS R00927; HS$IFNB_12; Quality: 2; human, Homo sapiens BS R00946; HS$ISG15_02; Quality: 4; human, Homo sapiens BS R00949; HS$ISG15_05; Quality: 2; human, Homo sapiens BS R00950; HS$ISG54_01; Quality: 2; human, Homo sapiens BS R02187; ISGF2$CONS; Quality: 6 BS R01061; MOUSE$M1H2KB_09; Quality: 4; mouse, Mus musculus XX DR EMBL: L05072; HSIFNRF1A(g). DR EMBL: X14454; HSIRF1(r). DR SwissProt: P10914; IRF1_HUMAN. DR PIR: B31595; B31595. DR PIR: S04075; S04075. DR Compel: C00060 DR Compel: C00061 XX RN [1] RA Kessler D. S., Levy D. E., Darnell Jr. J. E. RT Two interferon-induced nuclear factors bind a single RT promoter element in interferon-stimulated genes RL Proc. Natl. Acad. Sci. USA 85:8521-8525 (1988). RN [2] RA Reich N. C., Darnell Jr. J. E. RT Differential binding of interferon-induced factors RT to an oligonucleotide that mediates transcriptional activation RL Nucleic Acids Res. 17:3415-3424 (1989). RN [3] RA Harroch S., Revel M., Chebath J. RT Induction by interleukin-6 of interferon regulatory RT factor 1 (IRF-1) gene expression through the palindromic RT interferon response element pIRE and cell type-dependent RT control of IRF-1 binding to DNA RL EMBO J. 13:1942-1949 (1994). RN [4] RA Tanaka N., Kawakami T., Taniguchi T. RT Recognition DNA sequences of interferon regulatory RT factor 1 (IRF-1) and IRF-2, regulators of cell growth RT and the interferon system RL Mol. Cell. Biol. 13:4531-4538 (1993). RN [5] RA Reis L. F. L., Harada H., Wolchok J. D., Taniguchi T., Vilcek J. RT Critical role of a common transcription factor, IRF-1, RT in the regulation of IFN-beta and IFN-inducible genes RL EMBO J. 11:185-193 (1992). RN [6] RA Sims S. H., Cha Y., Romine M. F., Gao P., Gottlieb K., Deisseroth A. B. RT A novel interferon-inducible domain: structural and RT functional analysis of the human interferon regulatory RT factor 1 gene promoter RL Mol. Cell. Biol. 13:690-702 (1993). RN [7] RA Pine R., Canova A., Schindler C. RT Tyrosine phosphorylated p91 binds to a single element RT in the ISGF2/IRF-1 promoter to mediate induction by RT IFNalpha and IFNgamma, and is likely to autoregulate the p91 gene RL EMBO J. 13:158-167 (1994). RN [8] RA Bovolenta C., Driggers P. H., Marks M. S., Medin J. RA A., Politis A. D., Vogel S. N., Levy D. E., Sakaguchi RA K., Appella E., Coligan J. E., Ozato K. RT Molecular interactions between interferon consensus RT sequence binding protein and members of the interferon RT regulatory factor family RL Proc. Natl. Acad. Sci. USA 91:5046-5050 (1994). RN [9] RA Harada H., Kitagawa M., Tanaka N., Yamamoto H., Harada RA K., Ishihara M., Taniguchi T. RT Anti-oncogenic and oncogenic potentials of interferon RT regulatory factors-1 and -2 RL Science 259:971-974 (1993). RN [10] RA Willman C. L., Sever C., Pallavicini M. G., Harada RA H., Tanaka N., Slovak M. L., Yamamoto H., Harada K., RA Meeker T. C., List A. F., Taniguchi T. RT Deletion of IRF-1, mapping to chromosome 5q31.1, in RT human leukemia and preleukemic myelodysplasia RL Science 259:968-971 (1993). RN [11] RA Harada H., Takahashi E.-I., Itoh S., Harada K., Hori T.-A., Taniguchi T. RT Structure and regulation of the human interferon regulatory RT factor 1 (IRF-1) and IRF-2 genes: implications for RT a gene network in the interferon system RL Mol. Cell. Biol. 14:1500-1509 (1994). RN [12] RA Pine R., Darnell J. E. RT In Vivo Evidence of Interaction between Interferon-Stimulated RT Gene Factors and the Interferon-Stimulated Response Element RL Mol. Cell. Biol. 9:3533-3537 (1989). RN [13] RA Pine R., Decker T., Kessler D. S., Levy D. E., Darnell J. E. RT Purification and Cloning of Interferon-Stimulated RT Gene Factor 2 (ISGF2): ISGF2 (IRF-1) Can Bind to the RT Promoters of Both Beta Interferon- and Interferon-Stimulated RT Genes but Is Not a Primary Transcriptional Activator of Either RL Mol. Cell. Biol. 10:2448-2457 (1990). RN [14] RA Imam A. M. A., Ackrill A. M., C Dale T., Kerr I. M., Stark G. R. RT Transcription factors induced by interferons alpha and gamma RL Nucleic Acids Res. 18:6573-6580 (1990). RN [15] RA Keller A. D., Maniatis T. RT Identification and characterization of a novel repressor RT of beta-interferon gene expression RL Genes Dev. 5:868-879 (1991). XX // AC T00424 XX ID T00424 XX DT 14.12.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA IRF-1 XX SY ISGF2; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0022; trp; 3.5.3.0.1. XX SZ 328 AA; 37.1 kDa (cDNA), 37 kDa (SDS) XX SQ MPITRMRMRPWLEMQINSNQIPGLSWINKEEMIFQIPWKHAALHGWDINKDACLFRSWAI SQ HTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKNQR SQ KERKSKSSRDTKSKTKRKLCGDSSPDTLSDGLSSSTLPDDHSSYTAQGYLGQDLDMDRDI SQ TPALSPCVVSSSLSEWHMQMDIMPDSTTDLYNLQVSPMPSTSEAATDEDEEGKLPEDIMK SQ LFEQSEWQPTHVDGKGYLLNEPGAQLSTVYGDFSCKEEPEIDSPGGDIEIGIQRVFTEMK SQ NMDPVMWMDTLLGNSTRPPSIQAIPCAP XX SC SwissProt #P23570 XX FT 11 77 tryptophan cluster (W-X14-W-X11-W-X19-W-X18-W) FT 125 165 serine-/threonine-rich region (17/41) FT 223 246 acidic region (10/24) XX SF M-form appears as 56-kDa protein XX FF immediate-early gene, induced by prolactin in lymphoma cells [5]; FF here, two induction peaks have been found at early FF G1 and during G1/S transition [2]; FF same DNA binding specificity as IRF-2 XX MX M00062; V$IRF1_01 XX BS R02187; ISGF2$CONS; Quality: 6 XX DR EMBL: M34253; RRIRF1A(r). DR SwissProt: P23570; IRF1_RAT. DR PIR: A36330; A36330. XX RN [1] RA Tanaka N., Kawakami T., Taniguchi T. RT Recognition DNA sequences of interferon regulatory RT factor 1 (IRF-1) and IRF-2, regulators of cell growth RT and the interferon system RL Mol. Cell. Biol. 13:4531-4538 (1993). RN [2] RA Stevens A. M., Yu-Lee L.-Y. RT The transcription factor interferon regulatory factor-1 RT is expressed during both early G1 and G1/S transition RT in the prolactin-induced lymphocyte cell cycle RL Mol. Endocrinol. 6:2236-2243 (1992). RN [3] RA Nielsch U., Zimmer S. G., Babiss L. E. RT Changes in NF-kappaB and ISGF3 binding activities RT are responsible for differences in MHC and beta-IFN RT gene expression in Ad5- versus Ad12-transformed cells RL EMBO J. 10:4169-4175 (1991). RN [4] RA Pine R., Decker T., Kessler D. S., Levy D. E., Darnell J. E. RT Purification and Cloning of Interferon-Stimulated RT Gene Factor 2 (ISGF2): ISGF2 (IRF-1) Can Bind to the RT Promoters of Both Beta Interferon- and Interferon-Stimulated RT Genes but Is Not a Primary Transcriptional Activator of Either RL Mol. Cell. Biol. 10:2448-2457 (1990). RN [5] RA Yu-Lee L.-Y., Hrachovy J. A., Stevens A. M., Schwarz L. A. RT Interferon-Regulatory Factor 1 Is an Immediate-Early RT Gene under Transcriptional Regulation by Prolactin in Nb2 T Cells RL Mol. Cell. Biol. 10:3087-3094 (1990). RN [6] RA Imam A. M. A., Ackrill A. M., C Dale T., Kerr I. M., Stark G. R. RT Transcription factors induced by interferons alpha and gamma RL Nucleic Acids Res. 18:6573-6580 (1990). XX // AC T00425 XX ID T00425 XX DT 15.03.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA IRF-2 XX SY PRDI-BFc; PRDI-BFi; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0022; trp; 3.5.3.0.2. XX SZ 349 AA; 39.5 kDa (cDNA) XX SQ MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAI SQ HTGKHQPGIDKPDPKTWKANFRCAMNSLPDIEEVKDRSIKKGNNAFRVYRMLPLSERPSK SQ KGKKPKTEKEERVKHIKQEPVESSLGLSNGVSGFSPEYAVLTSAIKNEVDSTVNIIVVGQ SQ SHLDSNIEDQEIVTNPPDICQVVEVTTESDDQPVSMSELYPLQISPVSSYAESETTDSVA SQ SDEENAEGRPHWRKRSIEGKQYLSNMGTRNTYLLPSMATFVTSNKPDLQVTIKEDSCPMP SQ YNSSWPPFTDLPLPAPVTPTPSSSRPDRETRASVIKKTSDITQARVKSC XX SC SwissProt #P23906 XX FT 11 77 tryptophan cluster (W-X14-W-X11-W-X19-W-X18-W) XX SF highly similar to IRF-2 (62% identity within the N-terminal SF part, 25% between the C-terminal sequences), but lacking SF the acidic region of IRF-1 [1]; XX FF constitutive transcriptional repressor, thus negative FF regulator of interferon-beta expression; FF same DNA binding specificity as IRF-1; FF transforming potential, antagonizing IRF-1 [6]; FF required for normal hematopoiesis and B lymphopoieses [4]; FF enhanced levels after viral infection, peak after 4h [1]; FF functional in differentiated cells only [8]; XX IN T00402; ICSBP; mouse, Mus musculus. XX MX M00063; V$IRF2_01 XX BS R04222; AS$IRF_01; Quality: 3 BS R00915; HS$IFNA1_01; Quality: 6; human, Homo sapiens BS R00917; HS$IFNB_02; Quality: 6; human, Homo sapiens BS R00919; HS$IFNB_04; Quality: 6; human, Homo sapiens BS R03126; MOUSE$IL7R_01; Quality: 6; mouse, Mus musculus BS R01051; MOUSE$M1H2DD_02; Quality: 6; mouse, Mus musculus XX DR EMBL: J03168; MMIRF12(r). DR SwissProt: P23906; IRF2_MOUSE. DR PIR: A32828; A32828. XX RN [1] RA Harada H., Fujita T., Miyamoto M., Kimura Y., Maruyama RA M., Furia A., Miyata T., Taniguchi T. RT Structurally similar but functionally distinct factors, RT IRF-1 and IRF-2, bind to the same regulatory elements RT of IFN and IFN-inducible genes RL Cell 58:729-739 (1989). RN [2] RA Watanabe N., Sakakibara J., Hovanessian A. G., Taniguchi T., Fujita T. RT Activation of IFN-beta element by IRF-1 requires a RT post-translational event in addition to IRF-1 synthesis RL Nucleic Acids Res. 19:4421-4428 (1991). RN [3] RA Tanaka N., Kawakami T., Taniguchi T. RT Recognition DNA sequences of interferon regulatory RT factor 1 (IRF-1) and IRF-2, regulators of cell growth RT and the interferon system RL Mol. Cell. Biol. 13:4531-4538 (1993). RN [4] RA Matsuyama T., Kimura T., Kitagawa M., Pfeffer K., RA Kawakami T., Watanabe N., Kuendig T. M., Amakawa R., RA Kishihara K., Wakeham A., Potter J., Furlonger C. RA L., Narendran A., Suzuki H., Ohashi P. S., Paige C. RA J., Taniguchi T., Mak T. W. RT Targeted disruption of IRF-1 or IRF-2 results in abnormal RT type I IFN gene induction and aberrant lymphocyte developement RL Cell 75:83-97 (1993). RN [5] RA Bovolenta C., Driggers P. H., Marks M. S., Medin J. RA A., Politis A. D., Vogel S. N., Levy D. E., Sakaguchi RA K., Appella E., Coligan J. E., Ozato K. RT Molecular interactions between interferon consensus RT sequence binding protein and members of the interferon RT regulatory factor family RL Proc. Natl. Acad. Sci. USA 91:5046-5050 (1994). RN [6] RA Harada H., Kitagawa M., Tanaka N., Yamamoto H., Harada RA K., Ishihara M., Taniguchi T. RT Anti-oncogenic and oncogenic potentials of interferon RT regulatory factors-1 and -2 RL Science 259:971-974 (1993). RN [7] RA Pleimann C. M., Gimpel S. D., Park L. S., Harada H., RA Taniguchi T., Ziegler S. F. RT Organization of the murine and human interleukin-7 RT receptor genes: two mRNAs generated by differential RT splicing and presence of a type I-interferon-inducible promoter RL Mol. Cell. Biol. 11:3052-3059 (1991). RN [8] RA Harada H., Willison K., Sakakibara J., Miyamoto M., Fujita T., Taniguchi T. RT Absence of the type I IFN system in EC cells: transcriptional RT activator (ITF-1) and repressor (IRF-2) genes are developmentally regulated RL Cell 63:303-312 (1990). XX // AC T00426 XX ID T00426 XX DT 15.10.92 (created); ewi. XX FA alpha-IRP XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 85 kDa XX FF Sp1-related XX BS R00510; MOUSE$AAG_04; Quality: 6; mouse, Mus musculus XX RN [1] RA Kim C. G., Barnhart K. M., Sheffery M. RT Purification of Multiple Erythroid Cell Proteins That RT Bind the Promoter of the alpha-Globin Gene RL Mol. Cell. Biol. 8:4270-4281 (1988). RN [2] RA Barnhart K. M., Kim C. G., Banerji S. S., Sheffery M. RT Identification and Characterization of Multiple Erythroid RT Cell Proteins That Interact with the Promoter of the RT Murine alpha-Globin Gene RL Mol. Cell. Biol. 8:3215-3226 (1988). XX // AC T00427 XX ID T00427 XX DT 15.10.92 (created); ewi. DT 26.01.93 (updated); hse. XX FA ISGF-1 XX SY ISGF1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R02897; HS$GBP_01; Quality: 6; human, Homo sapiens BS R00945; HS$ISG15_01; Quality: 6; human, Homo sapiens BS R00948; HS$ISG15_04; Quality: 6; human, Homo sapiens BS R02186; ISGF1$CONS; Quality: 6 XX RN [1] RA Reich N. C., Darnell Jr. J. E. RT Differential binding of interferon-induced factors RT to an oligonucleotide that mediates transcriptional activation RL Nucleic Acids Res. 17:3415-3424 (1989). RN [2] RA Nielsch U., Zimmer S. G., Babiss L. E. RT Changes in NF-kappaB and ISGF3 binding activities RT are responsible for differences in MHC and beta-IFN RT gene expression in Ad5- versus Ad12-transformed cells RL EMBO J. 10:4169-4175 (1991). RN [3] RA Pine R., Darnell J. E. RT In Vivo Evidence of Interaction between Interferon-Stimulated RT Gene Factors and the Interferon-Stimulated Response Element RL Mol. Cell. Biol. 9:3533-3537 (1989). RN [4] RA Imam A. M. A., Ackrill A. M., C Dale T., Kerr I. M., Stark G. R. RT Transcription factors induced by interferons alpha and gamma RL Nucleic Acids Res. 18:6573-6580 (1990). RN [5] RA Harada H., Willison K., Sakakibara J., Miyamoto M., Fujita T., Taniguchi T. RT Absence of the type I IFN system in EC cells: transcriptional RT activator (ITF-1) and repressor (IRF-2) genes are developmentally regulated RL Cell 63:303-312 (1990). XX // AC T00428 XX ID T00428 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA ISGF-3 XX SY E factor; factor E; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 48+84+91+113 kDa (SDS) XX SF two main constituents (alpha and gamma) [9]; SF ISGF3alpha has three subunits (84 kDa, 91 kDa, 113 kDa) [15]; SF ISGF3gamma is a single 48 kDa protein belonging to the IRF family [7]; SF the gamma subunit has DNA-binding potential by its SF own, but with 25-fold decreased affinity and slightly SF different sequence specificity due to the DNA-contacting SF properties of ISGF3alpha [15], [8]; SF tyrosine-phosphorylation of all three subunits of SF ISGF-3alpha which all contain SH2 and SH3 domains [10]; XX FF multimeric complex, rapid interferon response factor; FF induced from cytoplasmic precursors (alpha and gamma) [9], [15]; FF ISGF-3alpha is induced by IFN-alpha/beta (by tyrosine phosphorylation) [10]; FF association of subunits and nuclear translocation FF after phosphorylation of ISGF-3alpha [4], [5]; FF inhibited by E1A [11]; XX MX M00258; V$ISRE_01 XX BS R00001; HS$6-16_01; Quality: 6; human, Homo sapiens BS R00003; HS$9-27_01; Quality: 6; human, Homo sapiens BS R02402; HS$IFI_03; Quality: 6; human, Homo sapiens BS R00947; HS$ISG15_03; Quality: 6; human, Homo sapiens BS R00949; HS$ISG15_05; Quality: 6; human, Homo sapiens BS R00950; HS$ISG54_01; Quality: 6; human, Homo sapiens BS R02188; ISGF3$CONS; Quality: 6 XX RN [1] RA Ackrill A. M., Foster G. R., Laxton C. D., Flavell RA D. M., Stark G. R., Kerr I. M. RT Inhibition of the cellular response to interferons RT by products of the adenovirus type 5 E1A oncogene RL Nucleic Acids Res. 19:4387-4393 (1991). RN [2] RA Kessler D. S., Levy D. E., Darnell Jr. J. E. RT Two interferon-induced nuclear factors bind a single RT promoter element in interferon-stimulated genes RL Proc. Natl. Acad. Sci. USA 85:8521-8525 (1988). RN [3] RA Reich N. C., Darnell Jr. J. E. RT Differential binding of interferon-induced factors RT to an oligonucleotide that mediates transcriptional activation RL Nucleic Acids Res. 17:3415-3424 (1989). RN [4] RA Levy D. E., Kessler D. S., Pine R., Darnell Jr. J. E. RT Cytoplasmic activation of ISGF3, the positive regulator RT of interferon-alpha-stimulated transcription, reconstituted in vitro RL Genes Dev. 3:1362-1371 (1989). RN [5] RA Kessler D. S., Levy D. E. RT Protein kinase activity required for an early step RT in interferon-alpha signaling RL J. Biol. Chem. 266:23471-23476 (1991). RN [6] RA Gutch M. J., Daly C., Reich N. C. RT Tyrosine phosphorylation is required for activation RT of an alpha interferon-stimulated transcription factor RL Proc. Natl. Acad. Sci. USA 89:11411-11415 (1992). RN [7] RA Veals S. A., Schindler C., Leonhard D., Fu X.-Y., RA Aebersold R., Darnell Jr. J. E., Levy D. E. RT Subunit of an alpha-interferon-responsive transcription RT factor is related to interferon regulatory factor RT and Myb families of DNA-binding proteins RL Mol. Cell. Biol. 12:3315-3324 (1992). RN [8] RA Veals S. A., Santa Maria T., Levy D. E. RT Two domains of ISGF3gamma that mediate protein-DNA RT and protein-protein interactions during transcription RT factor assembly contribute to DNA-binding specificity RL Mol. Cell. Biol. 13:196-206 (1993). RN [9] RA Levy D. E., Kessler D. S., Pine R., Reich N., Darnell Jr. J. E. RT Interferon-induced nuclear factors that bind a shared RT promoter element correlate with positive and negative control RL Genes Dev. 2:383-393 (1988). RN [10] RA Fu X.-Y. RT A transcription factor with SH2 and SH3 domains is RT directly activated by an interferon alpha-induced RT cytoplasmic protein tyrosine kinase(s) RL Cell 70:323-335 (1992). RN [11] RA Nielsch U., Zimmer S. G., Babiss L. E. RT Changes in NF-kappaB and ISGF3 binding activities RT are responsible for differences in MHC and beta-IFN RT gene expression in Ad5- versus Ad12-transformed cells RL EMBO J. 10:4169-4175 (1991). RN [12] RA Pine R., Darnell J. E. RT In Vivo Evidence of Interaction between Interferon-Stimulated RT Gene Factors and the Interferon-Stimulated Response Element RL Mol. Cell. Biol. 9:3533-3537 (1989). RN [13] RA Foster G. R., Ackrill A. M., Goldin R. D., Kerr I. RA M., Thomas H. C., Stark G. R. RT Expression of the terminal protein region of hepatitis RT B virus inhibits cellular responses to interferons RT alpha and gamma and double-stranded RNA RL Proc. Natl. Acad. Sci. USA 88:2888-2892 (1991). RN [14] RA Dale T. C., Ali Imam A. M., Kerr I. M., Stark G. R. RT Rapid activation by interferon alpha of a latent DNA-binding RT protein present in the cytoplasm of untreated cells RL Proc. Natl. Acad. Sci. USA 86:1203-1207 (1989). RN [15] RA Kessler D. S., Veals S. A., Fu X.-X., Levy D. E. RT Interferon-alpha regulates nuclear translocation and RT DNA-binding affinity of ISGF3, a multimeric transcriptional activator RL Genes Dev. 4:1753-1765 (1990). XX // AC T00429 XX ID T00429 XX DT 25.01.93 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA ISRF XX SY interferon-alpha/beta-stimulated response factor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SF phosphorylation XX FF activator; FF cytoplasmic complex with inhibitor ISRFI; FF dissociation and nuclear translocation upon IFN-alpha/beta stimulation; FF phosphorylation essential for DNA binding XX BS R00165; MOUSE$OAS_06; Quality: 6; mouse, Mus musculus XX RN [1] RA Yan C., Tamm I. RT Protein factors that bind to the murine 2',5'-oligoadenylate RT synthetase ME-12 gene 5' upstream regulatory region RL J. Biol. Chem. 265:20188-20194 (1990). XX // AC T00430 XX ID T00430 XX DT 25.01.93 (created); ewi. XX FA ISRFI XX SY ISRF inhibitor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX FF cytoplasmic inhibitor of ISRF; FF dissociates upon stimulation with IFN-alpha/beta XX RN [1] RA Yan C., Tamm I. RT Protein factors that bind to the murine 2',5'-oligoadenylate RT synthetase ME-12 gene 5' upstream regulatory region RL J. Biol. Chem. 265:20188-20194 (1990). XX // AC T00431 XX ID T00431 XX DT 15.10.92 (created); ewi. DT 16.03.94 (updated); hwi. XX FA ITF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00925; HS$IFNB_10; Quality: 6; human, Homo sapiens XX RN [1] RA Zinn K., Maniatis T. RT Detection of factors that interact with the human RT beta-interferon regulatory region in vivo by DNAase I footprinting RL Cell 45:611-618 (1986). XX // AC T00432 XX ID T00432 XX DT 20.10.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA ITF-1 XX SY E2-5; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0010; bHLH; 1.2.1.0.1.3. XX SZ >582 AA XX SQ GGGECLAWCGPSAVHRCADVGLGMVSARTAPGKSGERGAYASFGRDAGVGGLTQAGFLSG SQ ELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPS SQ SGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLP SQ LPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHT SQ PPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQ SQ WPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASG SQ FTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRA SQ GATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSTDEVLSLEEKDLRDRERRM SQ ANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLN SQ PKAACLKRREEEKVSGVVGDPQMVLSAPHPGLSEAHNPAGHM XX SC SwissProt #P15883 (partial sequence) XX FT 1 427 transcription activation region FT 329 357 potential leucine zipper (L2TL2) FT 478 489 basic region FT 490 531 helix-loop-helix domain FT 390 404 potential leucine zipper (L3) XX SF splice variant of E12, identical to E47 except its first exon [5]; XX FF activator; FF cooperating with TFE3, it can mediate lymphoid-specific FF activation through IgH enhancer elements muE5 and muE3; FF in this context, ITF-1 displaces a repressor (ZEB) FF thus giving way for activation by TFE3 [3]; XX IN T00403; Id1; mouse, Mus musculus. IN T00433; ITF-2; human, Homo sapiens. IN T00520; Myf-4; human, Homo sapiens. IN T00521; Myf-5; human, Homo sapiens. IN T00522; Myf-6; human, Homo sapiens. IN T00524; MyoD; clawed frog, Xenopus laevis. IN T00525; MyoD; human, Homo sapiens. IN T00526; MyoD; mouse, Mus musculus. IN T00527; MyoD; monkey, Cercopithecus aethiops. IN T00949; Myf-5; clawed frog, Xenopus laevis. IN T01128; MyoD; chick, Gallus gallus. XX BS R00913; RAT$INS2_01; Quality: 1; rat, Rattus norvegicus XX DR EMBL: X52078; HSITF1(r). DR SwissProt: P15883; ITF1_HUMAN. DR PIR: S10099; S10099. XX RN [1] RA Wilson R. B., Kiledjian M., Shen C.-P., Benezra R., RA Zwollo P., Dymecki S. M., Desiderio S. V., Kadesch T. RT Repression of immunoglobulin enhancers by the helix-loop-helix RT protein Id: implications for B-lymphoid-cell development RL Mol. Cell. Biol. 11:6185-6191 (1991). RN [2] RA Genetta T., Ruezinsky D., Kadesch T. RT Displacement of an E-box-binding repressor by basic RT helix-loop-helix proteins: implications for B-cell RT specificity of the immunoglobulin heavy-chain enhancer RL Mol. Cell. Biol. 14:6153-6163 (1994). RN [3] RA Ruezinsky D., Beckmann H., Kadesh T. RT Modulation of the Igh enhancer's cell type through a genetic switch RL Genes Dev. 5:29-37 (1991). RN [4] RA Henthorn P., Kiledjian M., Kadesch T. RT Two distinct transcription factors that bind the immunoglobulin RT enhancer muE5/kappaE2 motif RL Science 247:467-470 (1990). RN [5] RA Henthorn P., McCarrick-Walmsley R., Kadesch T. RT Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor RL Nucleic Acids Res. 18:677-677 (1990). XX // AC T00433 XX ID T00433 XX DT 20.10.92 (created); ewi. DT 20.05.97 (updated); ewi. XX FA ITF-2 XX SY E2-2; E32; SEF2-1B; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0010; bHLH; 1.2.1.0.2.1. XX SZ 667 AA; 71.2 kDa (cDNA) XX SQ MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWG SQ NGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQG SQ CHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGL SQ PSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAG SQ MLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPA SQ NGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTA SQ VWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHG SQ IIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQ SQ SATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKD SQ IKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKP SQ QTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDA SQ SNHMGQM XX SC conceptually translated from EMBL/GenBank/DDBJ #M74719 XX FT 46 497 transcription activation region FT 379 400 potential leucine repeat (LILL) FT 565 576 basic region FT 577 618 helix-loop-helix domain XX SF positions refer to the presumably complete sequence SF of SEF2-1B in [6], which appears to occur in several splice variants [6]; SF a novel loop-helix motif has been proposed in the SF trans-activation domain which is also found in E2A SF proteins, HEB, and Daughterless [5]; XX FF activator [8], [5]; FF in pre-B cells expressed together with E2A proteins, FF but switched off in mature B cells [4]; XX IN T00403; Id1; mouse, Mus musculus. IN T00432; ITF-1; human, Homo sapiens. IN T00506; MEF1; mouse, Mus musculus. IN T00520; Myf-4; human, Homo sapiens. IN T00521; Myf-5; human, Homo sapiens. IN T00522; Myf-6; human, Homo sapiens. IN T00524; MyoD; clawed frog, Xenopus laevis. IN T00525; MyoD; human, Homo sapiens. IN T00526; MyoD; mouse, Mus musculus. IN T00527; MyoD; monkey, Cercopithecus aethiops. IN T00790; Tal-1; human, Homo sapiens. IN T00949; Myf-5; clawed frog, Xenopus laevis. IN T01128; MyoD; chick, Gallus gallus. IN T01448; Tal-1beta; human, Homo sapiens. IN T01503; HEB; human, Homo sapiens. IN T01606; Id1.25; rat, Rattus norvegicus. IN T01807; Id1; rat, Rattus norvegicus. XX MX M00070; V$TAL1BETAITF2_01 XX BS R04157; AS$TAL1_01; Quality: 2 BS R04158; MOUSE$IGH_59; Quality: 2; mouse, Mus musculus BS R00242; MOUSE$MCK_03; Quality: 2; mouse, Mus musculus BS R03074; RAT$MLC_01; Quality: 2; rat, Rattus norvegicus XX DR EMBL: X52079; HSITF2(r). DR EMBL: M74719; HSSEF21B(r). DR SwissProt: P15884; ITF2_HUMAN. DR PIR: S08461; S08461. XX RN [1] RA Hsu H.-L., Huang L., Tsan J. T., Funk W., Wright W. RA E., Hu J.-S., Kingston R. E., Baer R. RT Preferred sequences for DNA recognition by the TAL1 RT helix-loop-helix proteins RL Mol. Cell. Biol. 14:1256-1265 (1994). RN [2] RA Hu J.-S., Olson E. N., Kingston R. E. RT HEB, a helix-loop-helix protein related to E2A and RT ITF2 that can modulate the DNA-binding ability of RT myogenic regulatory factors RL Mol. Cell. Biol. 12:1031-1042 (1992). RN [3] RA Einarson M. B., Chao M. V. RT Regulation of Id1 and its association with basic helix-loop-helix RT proteins during nerve growth factor-induced differentiation of PC12 cells RL Mol. Cell. Biol. 15:4175-4183 (1995). RN [4] RA Bain G., Gruenwald S., Murre C. RT E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins RL Mol. Cell. Biol. 13:3522-3529 (1993). RN [5] RA Quong M. W., Massari M. E., Zwart R., Murre C. RT A new transcriptional-activation motif restricted RT to a class of helix-loop-helix proteins is functionally RT conserved in both yeast and mammalian cells RL Mol. Cell. Biol. 13:792-800 (1993). RN [6] RA Corneliussen B., Thornell A., Hallberg B., Grundstroem T. RT Helix-loop-helix transcriptional activators bind to RT a sequence in glucocorticoid response elements of retrovirus enhancers RL J. Virol. 65:6084-6093 (1991). RN [7] RA Lassar A. B., Davis R. L., Wright W. E., Kadesch T., RA Murre C., Voronova A., Baltimore D., Weintraub H. RT Functional activity of myogenic HLH proteins requires RT hetero-oligomerization with E12/E47-like proteins in vivo RL Cell 66:305-315 (1991). RN [8] RA Henthorn P., Kiledjian M., Kadesch T. RT Two distinct transcription factors that bind the immunoglobulin RT enhancer muE5/kappaE2 motif RL Science 247:467-470 (1990). XX // AC T00434 XX ID T00434 XX DT 14.12.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA IUF-1 XX SY insulin upstream factor 1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 50 kDa (SDS) XX SF may be composed of 2 components (46 kDa and 115 kDa), SF a 65 kDa peptide has also been observed SF 50 kDa protein identified by UV laser cross-linking XX BS R02709; HS$INS_03; Quality: 6; human, Homo sapiens BS R04228; IUF1$CONS_01; Quality: 6 BS R04225; RAT$GK_01; Quality: 4; rat, Rattus norvegicus BS R04226; RAT$GK_02; Quality: 4; rat, Rattus norvegicus BS R04227; RAT$GK_03; Quality: 4; rat, Rattus norvegicus XX RN [1] RA Scott V., Clark A. R., Hutton J. C., Docherty K. RT Two proteins act as the IUF1 insulin gene enhancer binding factor RL FEBS Lett. 290:27-30 (1991). RN [2] RA Shelton K. D., Franklin A. J., Khoor A., Beechem J., Magnuson M. A. RT Multiple elements in the upstream glucokinase promoter RT contrbute to transcription in insulinoma cells RL Mol. Cell. Biol. 12:4578-4589 (1992). RN [3] RA Boam D. S. W., Clark A. R., Docherty K. RT Positive and Negative Regulation of the Human Insulin RT Gene by Multiple Trans-acting Factors RL J. Biol. Chem. 265:8285-8296 (1990). XX // AC T00435 XX ID T00435 XX DT 25.01.93 (created); ewi. XX FA JRF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 50 kDa XX BS R02847; HS$GHA_09; Quality: 6; human, Homo sapiens XX RN [1] RA Andersen B., Kennedy G. C., Nilson J. H. RT A cis-acting element located between the cAMP response RT elements and CCAAT box augments cell-specific expression RT of the glycoprotein hormone alpha-subunit gene RL J. Biol. Chem. 265:21874-21880 (1990). XX // AC T00436 XX ID T00436 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA JunB XX SY Jun-B; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.1.1.4. XX SZ 344 AA; 35.8 kDa (cDNA) XX SQ MCTKMEQPFYHDDSYAAAGYGRSPGSLSLHDYKLLKPTLALNLADPYRGLKGPGARGPGP SQ EGSGAGSYFSGQGSDTGASLKLASTELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGG SQ TGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGASGGPQAGPGGVYAGPEPPPVYT SQ NLSSYSPASAPSGGSGTAVGTGSSYPTATISYLPHAPPFAGGHPAQLGLSRGASAFKEEP SQ QTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTL SQ KAENAGLSSAAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF XX SC SwissProt #P09450 XX IN T00122; c-Fos; mouse, Mus musculus. IN T00123; c-Fos; human, Homo sapiens. IN T00124; c-Fos; rat, Rattus norvegicus. IN T00125; c-Fos; chick, Gallus gallus. IN T00292; FraI; mouse, Mus musculus. IN T00437; Jun-D; mouse, Mus musculus. IN T01095; LRF-1; rat, Rattus norvegicus. IN T01208; FraI; rat, Rattus norvegicus. XX BS R00592; HS$GHA_02; Quality: 6; human, Homo sapiens XX DR EMBL: J03236; MMJUNBA(r). DR SwissProt: P09450; JUNB_MOUSE. DR PIR: A28963; TVMSJB. DR Compel: C00081 DR Compel: C00105 DR Compel: C00133 XX RN [1] RA Turner R., Tjian R. RT Leucine repeats and an adjacent DNA binding domain RT mediate the formation of functional cFos-cJun heterodimers RL Science 243:1689-1694 (1989). RN [2] RA Hsu J. C., Laz T., Mohn K. L., Taub R. RT Identification of LRF-1, a leucine-zipper protein RT that is rapidly and highly induced in regenerating liver RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991). RN [3] RA Binetruy B., Smeal T., Karin M. RT Ha-Ras augments c-Jun activity and stimulates phosphorylation RT of its activation domain RL Nature 351:122-127 (1991). RN [4] RA Nakabeppu Y., Nathans D. RT A naturally occurring truncated form of FosB that RT inhibits Fos/Jun transcriptional activity RL Cell 64:751-759 (1991). RN [5] RA Bossy-Wetzel E., Bravo R., Hanahan D. RT Transcription factors JunB and c-Jun are selectively RT up-regulated and functionally implicated in fibrosarcoma development RL Genes Dev. 6:2340-2351 (1992). RN [6] RA Chiu R., Angel P., Karin M. RT Jun-B differs in its biological properties from, and RT is a negative regulator of, c-Jun RL Cell 59:979-986 (1989). RN [7] RA Suzuki T., Okuno H., Yoshida T., Endo T., Nishina H., Iba H. RT Difference in transcriptional regulatory function between c-Fos and Fra-2 RL Nucleic Acids Res. 19:5537-5542 (1991). RN [8] RA Deng T., Karin M. RT JunB differs from c-Jun in its DNA-binding and dimerization RT domains, and represses c-Jun by formation of inactive heterodimers RL Genes Dev. 7:479-490 (1993). RN [9] RA Lord et al RT - RL Mol. Cell. Biol. 13:841-851 (1993). RN [10] RA Kobierski L. A., Chu H. M., Tan Y., Comb M. J. RT cAMP-dependent regulation of proenkephalin by JunD RT and JunB: positive and negative effects of AP-1 proteins RL Proc. Natl. Acad. Sci. USA 88:10222-10226 (1991). RN [11] RA Castellazzi M., Spyrou G., La Vista N., Dangy J.-P., RA Piu F., Yaniv M., Brun G. RT Overexpression of c-jun, junB, or junD affects cell growth differently RL Proc. Natl. Acad. Sci. USA 88:8890-8894 (1991). RN [12] RA Apel et al RT Regulation of the junB gene by v-src RL Mol. Cell. Biol. 12:3356-3364 (1992). RN [13] RA Kornhauser J. M., Nelson D. E., May K. E., Takahashi J. S. RT Regulation of jun-B mesenger RNA and AP-1 activity RT by light and a circadian clock RL Science 255:1581-1585 (1992). RN [14] RA Li L., Chambard J.-C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by RT myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [15] RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., RA Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B. RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB RL Mol. Cell. Biol. 13:1911-1919 (1993). RN [16] RA Ryder K., Lau L. F., Nathans D. RT A gene activated by growth factor is related to the oncogene v-jun RL Proc. Natl. Acad. Sci. USA 85:1487-1491 (1988). RN [17] RA Zerial M., Toschi L., Ryseck R.-P., Schuermann M., Mueller R., Bravo R. RT The product of a novel growth factor activated gene, RT fos B, interacts with JUN proteins enhancing their DNA binding activity RL EMBO J. 8:805-813 (1989). RN [18] RA Nakabeppu Y., Ryder K., Nathans D. RT DNA Binding Activities of Three Murine Jun Proteins: Stimulation by Fos RL Cell 55:907-915 (1988). RN [19] RA de Groot R. P., Auwerx J., Karperien M., Staels B., Kruijer W. RT Activation of junB by PKC and PKA signal transduction RT through a novel cis-acting element RL Nucleic Acids Res. 19:775-781 (1991). XX // AC T00437 XX ID T00437 XX DT 15.10.92 (created); ewi. DT 22.08.96 (updated); ewi. XX FA Jun-D XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.1.1.5. XX SZ 341 AA; 34.9 kDa (cDNA) XX SQ METPFYGEEALSGLAAGASSVAGATGAPGGGGFAPPGRAFPGAPPTSSMLKKDALTLSLA SQ EQGAAGLKPGSATAPSALRPDGAPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTS SQ TQFLYPKVAASEEQEFAEGFVKALEDLHKQSQLGAATAATSGAPAPPAPADLAATPGATE SQ TPVYANLSSFAGGAGPPGGAATVAFAAEPVPFPPPPGALGPPPPPHPPRLAALKDEPQTV SQ PDVPSFGDSPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQ SQ NTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY XX SC SwissProt #P15066 XX SF proline-rich region XX IN T00122; c-Fos; mouse, Mus musculus. IN T00123; c-Fos; human, Homo sapiens. IN T00124; c-Fos; rat, Rattus norvegicus. IN T00125; c-Fos; chick, Gallus gallus. IN T00292; FraI; mouse, Mus musculus. IN T00436; JunB; mouse, Mus musculus. IN T00437; Jun-D; mouse, Mus musculus. IN T01208; FraI; rat, Rattus norvegicus. XX BS R02666; AS$AP1_01; Quality: 6 BS R02667; AS$CRE_01; Quality: 6 BS R01225; PA$PY_07; Quality: 6; Py, polyoma virus XX DR EMBL: J04509; MMJUND(g). DR EMBL: X15358; MMJUNDA(r). DR EMBL: J05205; MMJUNDR(r). DR SwissProt: P15066; JUND_MOUSE. DR PIR: A35013; A35013. DR PIR: A32158; TVMSJD. DR Compel: C00105 XX RN [1] RA Hirai S.-I., Ryseck R.-P., Mechta F., Bravo R., Yaniv M. RT Characterization of junD: a new member of the jun proto-oncogene family RL EMBO J. 8:1433-1439 (1989). RN [2] RA Ryder K., Lanahan A., Perez-Albuerne E., Nathans D. RT Jun-D: A third member of the Jun gene family RL Proc. Natl. Acad. Sci. USA 86:1500-1503 (1989). RN [3] RA Suzuki T., Okuno H., Yoshida T., Endo T., Nishina H., Iba H. RT Difference in transcriptional regulatory function between c-Fos and Fra-2 RL Nucleic Acids Res. 19:5537-5542 (1991). RN [4] RA Kobierski L. A., Chu H.-M., Tan Y., Comb M. J. RT cAMP-dependent regulation of proenkephalin by JunD RT and JunB: positive and negative effects of AP-1 proteins RL Proc. Natl. Acad. Sci. USA 88:10222-10226 (1991). RN [5] RA Castellazzi M., Spyrou G., La Vista N., Dangy J.-P., RA Piu F., Yaniv M., Brun G. RT Overexpression of c-jun, junB, or junD affects cell growth differently RL Proc. Natl. Acad. Sci. USA 88:8890-8894 (1991). RN [6] RA Nakabeppu Y., Nathans D. RT A naturally occurring truncated form of FosB that RT inhibits Fos/Jun transcriptional activity RL Cell 64:751-759 (1991). RN [7] RA Pfarr C. M., Mechta F., Spyrou G., Lallemand D., Carillo S., Yaniv M. RT Mouse JunD negatively regulates fibroblast growth RT and antagonizes transformation by ras RL Cell 76:747-760 (1994). RN [8] RA de Groot R. P., Karperien M., Pals C., Kruijer W. RT Characterization of the mouse junD promoter-high basal RT level activity due to an octamer motif RL EMBO J. 10:2523-2532 (1991). RN [9] RA Li L., Chambard J.-C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by RT myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [10] RA Nakabeppu Y., Nathans D. RT The basic region of Fos mediates specific DNA binding RL EMBO J. 8:3833-3841 (1989). RN [11] RA Ryder K., Lau L. F., Nathans D. RT A gene activated by growth factor is related to the oncogene v-jun RL Proc. Natl. Acad. Sci. USA 85:1487-1491 (1988). RN [12] RA Nakabeppu Y., Ryder K., Nathans D. RT DNA Binding Activities of Three Murine Jun Proteins: Stimulation by Fos RL Cell 55:907-915 (1988). XX // AC T00438 XX ID T00438 XX DT 15.12.92 (created); ewi. XX FA kappaY factor XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP lymphoid cells XX FF activator, augments octamer element XX BS R02751; HS$IGKL_07; Quality: 6; human, Homo sapiens XX RN [1] RA Atchison M. L., Delmas V., Perry R. P. RT A novel upstream element compensates for an ineffectual RT octamer motif in an immunoglobulin Vkappa promoter RL EMBO J. 9:3109-3117 (1990). XX // AC T00439 XX ID T00439 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA KBF1 XX SY H2TF1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; . XX SZ 48 kDa; 50 kDa XX SQ MADDDPYGTGQMFHLNTALTHSIFNAELYSPEIPLSTDGPYLQILEQPKQRGFRFRYVCE SQ GPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGV SQ CTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLAYLQAEG SQ GGDRQLTDREKEIIRQAAVQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDS SQ KAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSP SQ TDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRK SQ RQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPG SQ VTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALA SQ STMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGD SQ SVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRV SQ GADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSL SQ PCLLLLVAAGAEVNAQEQKSGRTPLHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLH SQ IAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQV SQ FDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGIL SQ NNAFRLSPAPSKTLMDNYEVSGGTIKELMEALQQMGYTEAIEVIQAAFRTPATTASSPVT SQ TAQVHCLPLSSSSTRQHIDELRDSDSVCDSGVETSFRKLSFTESLTGDSPLLSLNKMPHG SQ YGQEGPIEGKI XX SC SwissProt #P25799 XX SF 2 zinc finger motifs XX CP differentiated cells XX FF exists in two forms, constitutively expressed. Binds FF to the kappaB motif. Implicated in MHC class II expression; FF different from AP-2 XX BS R01766; AS$KBF_01; Quality: 2 BS R02591; AS$KBF_02; Quality: 6 BS R02167; H2TF1$CONS; Quality: 6 BS R02189; KBF1$CONS; Quality: 6 BS R01095; MOUSE$B2MG_02; Quality: 6; mouse, Mus musculus BS R01057; MOUSE$M1H2KB_05; Quality: 6; mouse, Mus musculus BS R02336; MOUSE$M1H2KK_01; Quality: 6; mouse, Mus musculus XX DR EMBL: M57999; MMTFDBS(r). DR SwissProt: P25799; KBF1_MOUSE. DR PIR: A35696; A35696. DR PIR: A35697; A35697. XX RN [1] RA Yano O., Kanellopoulos J., Kieran M., Le Bail O., Israel A., Kourilsky P. RT Purification of KBF1, a common factor binding to both RT H-2 and beta2-microglobulin enhancers RL EMBO J. 6:3317-3324 (1987). RN [2] RA Israel A., Yano O., Logeat F., Kieran M., Kourilsky P. RT Two purified factors bind to the same sequence in RT the enhancer of mouse MHC class I genes: one of them RT is a positive regulator induced upon differentiation RT of teratocarcinoma cells RL Nucleic Acids Res. 17:5245 (1989). RN [3] RA Lenardo M., Rustgi A. K., Schievella A. R., Bernards R. RT Suppression of MHC class I gene expression by N-myc RT through enhancer inactivation RL EMBO J. 8:3351-3355 (1989). RN [4] RA Gilmore T. D. RT NF-kappaB, KBF1, dorsal, and related matters RL Cell 62:841-843 (1990). RN [5] RA Henseling U., Schmidt W., Schoeler H. R., Gruss P., Hatzopoulos A. K. RT A transcription factor interacting with the class RT I gene enhancer is inactive in tumorigenic cell lines RT which suppress major histocompatibility complex class I genes RL Mol. Cell. Biol. 10:4100-4109 (1990). RN [6] RA Rustgi A. K., Van'T Veer L. J., Bernards R. RT Two genes encode factors with NF-kappaB- and H2TF1-like RT DNA-binding properties RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990). RN [7] RA Henseling U., Schmidt W., Schoeler H. R., Gruss P., Hatzopoulos A. K. RT A transcription factor interacting with the class RT I gene enhancer is inactive in tumorigenic cell lines RT which suppress major histocompatibility complex class I genes RL Mol. Cell. Biol. 10:4100-4109 (1990). XX // AC T00440 XX ID T00440 XX DT 02.12.92 (created); ewi. XX FA KBF2 XX SY KBF-2; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 58 kDa (SDS) XX BS R02591; AS$KBF_02; Quality: 6 BS R02592; AS$KBF_03; Quality: 6 XX RN [1] RA Israel A., Yano O., Logeat F., Kieran M., Kourilsky P. RT Two purified factors bind to the same sequence in RT the enhancer of mouse MHC class I genes: one of them RT is a positive regulator induced upon differentiation RT of teratocarcinoma cells RL Nucleic Acids Res. 17:5245 (1989). XX // AC T00441 XX ID T00441 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA KBP-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; 2.3.4.0.4. XX SF at least 2 zinc finger motifs SF acidic region XX CP (retinal cells) XX BS R01095; MOUSE$B2MG_02; Quality: 6; mouse, Mus musculus BS R00879; MOUSE$IGKL_03; Quality: 6; mouse, Mus musculus XX DR EMBL: M61743; HSKBP1(r). XX RN [1] RA Rustgi A. K., Van't Veer L., Bernards R. RT Two genes encode factors with NF-kappaB- and H2TF1-like RT DNA-binding properties RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990). XX // AC T00442 XX ID T00442 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA 47-kDa CRE bind. prot. XX SY ATF; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO CREB, EPF, EIIA-EF, EIIaE-B XX SZ 37 + 47 kDa XX CP ovary XX BS R00322; AD$E2AE1_07; Quality: 6; adenovirus type 2 BS R02126; ATF$CONS; Quality: 6 BS R00471; HS$CFOS_14; Quality: 6; human, Homo sapiens BS R00963; MOUSE$LDHA_01; Quality: 6; mouse, Mus musculus BS R01217; RAT$PEPCK_06; Quality: 6; rat, Rattus norvegicus BS R01358; RAT$SSTA_01; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Kwast-Welfeld J., Soong C.-J., Short M. L., Jungmann R. A. RT Identification of Rat Ovarian Nuclear Factors That RT Interact with the cAMP-inducible Lactate Dehydrogenase A Subunit Promoter RL J. Biol. Chem. 264:6941-6947 (1989). XX // AC T00443 XX ID T00443 XX DT 15.10.92 (created); ewi. XX FA 75 kDa protein XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; OC lepidoptera; bombycoidea; bombycidae XX SZ 75 kDa XX BS R00448; BOMMO$F_01; Quality: 6; silk moth, Bombyx mori XX RN [1] RA Matsuno K., Suzuki T., Takiya S., Suzuki Y. RT Complex Formation with the Fibroin Gene Enhancer through RT a Protein-Protein Interaction Analyzed by a Modified DNA-binding Assay RL J. Biol. Chem. 264:4599-4604 (1989). XX // AC T00444 XX ID T00444 XX DT 26.01.93 (created); hse. XX FA Ker1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP keratinocytes XX FF controls keratinocyte-specific gene expression XX BS R03674; HS$EK14_01; Quality: 6; human, Homo sapiens BS R02190; KER1$CONS; Quality: 6 XX RN [1] RA Leask A., Rosenberg M., Vassar R., Fuchs E. RT Regulation of a human epidermal keratin gene: sequences RT and nuclear factors involved in keratinocyte-specific transcription RL Genes Dev. 4:1985-1998 (1990). XX // AC T00445 XX ID T00445 XX DT 03.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Kni XX SY Knirps; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0002; CC (rec); 2.1.2.13.1. XX SZ 429 AA; 45.6 kDa (cDNA) XX SQ MNQTCKVCGEPAAGFHFGAFTCEGCKSFFGRSYNNISTISECKNEGKCIIDKKNRTTCKA SQ CRLRKCYNVGMSKGGSRYGRRSNWFKIHCLLQEHEQAAAAAGKAPPLAGGVSVGGAPSAS SQ SPVGSPHTPGFGDMAAHLHHHHQQQQQQQVPRHPHMPLLGYPSYLSDPSAALPFFSMMGG SQ VPHQSPFQLPPHLLFPGYHASAAAAAASAADAAYRQEMYKHRQSVDSVESQNRFSPASQP SQ PVVQPTSSARQSPIDVCLEEDVHSVHSHQSSASLLHPIAIRATPTTPTSSSPLSFAAKMQ SQ SLSPVSVCSIGGETTSVVPVHPPTVSAQEGPMDLSMKTSRSSVHSFNDSGSEDQEVEVAP SQ RRKFYQLEAECLTTSSSSSSHSAAHSPNTTTAHAEVKRQKLGGAEATHFGGFAVAHNAAS SQ AMRGIFVCV XX SC SwissProt #P10734 XX CP abdominal segments 1-7 XX FF repressor of Krueppel expression; FF repressor of hairy in stripe 3 to 4 and 7; FF activator of hairy in stripes 5 and 6 XX BS R02283; DROME$KR_16; Quality: 1; fruit fly, Drosophila melanogaster XX DR EMBL: X13331; DMKNIRPS(empty). DR SwissProt: P10734; KNIR_DROME. DR PIR: S01919; S01919. DR Flybase: FBgn0001320; kni. XX RN [1] RA Hoch M., Gerwin N., Taubert H., Jaeckle H. RT Competition for overlapping sites in the regulatory RT region of the Drosophila gene Krueppel RL Science 256:94-97 (1992). RN [2] RA Riddihough G., Ish-Horowicz D. RT Individual stripe regulatory elements in the Drosophila RT hairy promoter respond to maternal, gap, and pair-rule genes RL Genes Dev. 5:840-854 (1991). XX // AC T00446 XX ID T00446 XX DT 15.10.92 (created); ewi. XX FA 43K protein XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 43 kDa XX CP brain XX FF rel. to CREB; FF ATF ? XX BS R00288; HS$DPOLB_02; Quality: 6; human, Homo sapiens XX RN [1] RA Zhu Z., Andrisani O. M., Pot D. A., Dixon J. E. RT Purification and Characterization of a 43-kDa Transcription RT Factor Required for Rat Somatostatin Gene Expression RL J. Biol. Chem. 264:6550-6556 (1989). XX // AC T00447 XX ID T00447 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA 50-55K protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO NF-kappaB XX SZ 50-55 kDa XX CP induced T-cells XX BS R00944; HS$IL2RA_05; Quality: 6; human, Homo sapiens XX RN [1] RA Lowenthal J. W., Ballard D. W., Boehnlein E., Greene W. C. RT Tumor necrosis factor alpha induces proteins that RT bind specifically to kB-like enhancer elements and RT regulate interleukin 2 receptor alpha-chain gene expression RT in primary human T lymphocytes RL Proc. Natl. Acad. Sci. USA 86:2331-2335 (1989). XX // AC T00448 XX ID T00448 XX DT 15.10.92 (created); ewi. XX FA 60K protein XX OS soybean, Glycine max OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC rosidae; fabales; fabaceae XX SZ 60 kDa XX BS R00964; SOYBN$LEC_01; Quality: 6; soybean, Glycine max BS R00965; SOYBN$LEC_02; Quality: 6; soybean, Glycine max XX RN [1] RA Jofuku K. D., Okamuro J. K., Goldberg R. B. RT Interaction of an embryo DNA binding protein with RT a soybean lectin gene upstream region RL Nature 328:734-737 (1987). XX // AC T00449 XX ID T00449 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA 62K protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO f-EBP, TCF, MAPF1 XX SZ 62 kDa XX BS R00472; MOUSE$CFOS_01; Quality: 4; mouse, Mus musculus XX RN [1] RA Ryan jr. W. A., Franza Jr. B. R., Gilman M. Z. RT Two distinct cellular phospholipoproteins bind to RT the c-fos serum response element RL EMBO J. 8:1785-1792 (1989). XX // AC T00450 XX ID T00450 XX DT 15.10.92 (created); ewi. XX FA 70-75K protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 70-75 kDa XX CP induced T-cells XX BS R00944; HS$IL2RA_05; Quality: 6; human, Homo sapiens XX RN [1] RA Lowenthal J. W., Ballard D. W., Boehnlein E., Greene W. C. RT Tumor necrosis factor alpha induces proteins that RT bind specifically to kB-like enhancer elements and RT regulate interleukin 2 receptor alpha-chain gene expression RT in primary human T lymphocytes RL Proc. Natl. Acad. Sci. USA 86:2331-2335 (1989). XX // AC T00451 XX ID T00451 XX DT 15.10.92 (created); ewi. XX FA 77+82K protein XX OS vaccinia virus OC viridae; ds-DNA enveloped viruses; poxviridae; chordopoxvirinae; OC orthopoxvirus XX SZ 77; 82 kDa XX BS R01558; VAV$VGF_01; Quality: 6; vaccinia virus XX RN [1] RA Broyles S. S., Yuen L., Shuman S., Moss B. RT Purification of a Factor Required for Transcription RT of Vaccinia Virus Early Genes RL J. Biol. Chem. 263:10754-10760 (1988). XX // AC T00452 XX ID T00452 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA 80-90K protein XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO HIVEN86A XX SZ 80-90 kDa XX CP induced T-cells XX BS R00944; HS$IL2RA_05; Quality: 6; human, Homo sapiens XX RN [1] RA Lowenthal J. W., Ballard D. W., Boehnlein E., Greene W. C. RT Tumor necrosis factor alpha induces proteins that RT bind specifically to kB-like enhancer elements and RT regulate interleukin 2 receptor alpha-chain gene expression RT in primary human T lymphocytes RL Proc. Natl. Acad. Sci. USA 86:2331-2335 (1989). XX // AC T00453 XX ID T00453 XX DT 15.10.92 (created); ewi. XX FA 96K-protein XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 96 kDa XX BS R03176; AAV$P5_03; Quality: 5; AAV, adeno-associated virus BS R00874; HS$IGH_03; Quality: 6; human, Homo sapiens XX RN [1] RA Araki K., Maeda H., Wang J., Kitamura D., Watanabe T. RT Purification of a Nuclear Trans-Acting Factor Involved RT in the Regulation of a Human Immunoglobulin Heavy Chain Gene RL Cell 53:723-730 (1988). XX // AC T00454 XX ID T00454 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Krox-20 XX SY EGR2 (human); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; 2.3.2.1.3. XX SZ 420 AA XX SQ MNGVAGDGMINIDMTGEKRPLDLPYPSSFAPISAPRNQTFTYMGKFSIDPQYPGASCYPE SQ GIINIVSAGILQGVTPPASTTASSSVTSASPNPLATGPLGVCTMSQTQPELDHLYSPPPP SQ PPPYSGCTGDLYQDPSAFLSPPSTTSTSSLAYQPPPSYPSPKPAMDPGLIPMIPDYPGFF SQ PSPCQRDPHGAAGPDRKPFPCPLDSLRVPPPLTPLSTIRNFTLGGPGAGVTGPGASGGGE SQ GPRLPGSGSAAVTATPYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSR SQ SDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDER SQ KRHTKIHLRQKERKSSAPSAPPSAQSSASGPGGSQAGGSLCGNSAIGGPLASCTSRTRTP XX SC SwissProt #P08152 XX SF 3 zinc finger motifs SF phosphorylation SF glycosylation SF each finger spans 3 nucleotides SF discrimination between Krox-20 and Sp1 binding sites by 2 side chains XX CP hindbrain (rhombomeres 3 and 5), neural crest, neural CP crest-derived boundary caps, glial components of cranial and spinal ganglia XX MX M00246; V$EGR2_01 XX BS R02147; EGR1$CONS; Quality: 1 BS R00721; MOUSE$HOX14_01; Quality: 6; mouse, Mus musculus BS R02085; MOUSE$HOX23_03; Quality: 6; mouse, Mus musculus XX DR EMBL: M24376; MMKROX1(g). DR EMBL: M24377; MMKROX2(g). DR EMBL: M20759; MMKROX20(g). DR EMBL: X06746; MMKROX2R(r). DR SwissProt: P08152; EGR2_MOUSE. DR PIR: A30136; A30136. DR PIR: B30136; B30136. DR PIR: S00256; S00256. XX RN [1] RA Lemaire P., Vesque C., Schmitt J., Stunnenberg H., Frank R., Charnay P. RT The serum-inducible mouse gene Krox-24 encodes a sequence-specific RT transcriptional activator RL Mol. Cell. Biol. 10:3456-3467 (1990). RN [2] RA Gilardi P., Schneider-Maunoury S., Charnay P. RT Krox-20: a candidate gene for the regulation of pattern RT formation in the hindbrain RL Biochimie 73:85-91 (1991). RN [3] RA Wilkinson D. G., Bhatt S., Chavrier P., Bravo R., Charnay P. RT Segment-specific expression of a zinc-finger gene RT in the developing nervous system of the mouse RL Nature 337:461-464 (1989). RN [4] RA Nardelli J., Gibson T. J., Vesque C., Charnay P. RT Base sequence discrimination by zinc-finger DNA-binding domains RL Nature 349:175-178 (1991). XX // AC T00455 XX ID T00455 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Krox-24 XX SY EGR1; EGR1 (human); ETR103 (human); NGFI-A; TIS-8; zif268; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; 2.3.2.1.2. XX SZ 533 AA; 82, 88 kDa (SDS) XX SQ MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGTPEGSGG SQ NSSSSTSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKAMVETSYPS SQ QTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSS SQ SASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPA SQ TKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQ SQ DLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIH SQ TGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQK SQ DKKADKSVVASPAASSLSSYPSPVATSYPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGF SQ PSPSVATTFASVPPAFPTQVSSFPSAGVSSSFSTSTGLSDMTATFSPRTIEIC XX SC SwissProt #P08046 XX SF 3 zinc finger motifs SF phosphorylation, glycosylation SF crystal structure (co-crystals with 11-bp DNA) XX CP predom. in bone and cartilage (embryogenesis) XX FF early growth response gene; FF increased by retinoic acid in preosteoblastic cells; FF alternative translation initiation XX MX M00243; V$EGR1_01 XX BS R00721; MOUSE$HOX14_01; Quality: 6; mouse, Mus musculus XX DR EMBL: M20157; MMEGR101(r). DR EMBL: M28844; MMKROX2S1(g). DR EMBL: M28845; MMKROX2S2(g). DR EMBL: M22326; MMTFEZIF(r). DR SwissProt: P08046; EGR1_MOUSE. DR PIR: A29883; A29883. DR PIR: A32065; A32065. DR PIR: JS0304; JS0304. XX RN [1] RA Lemaire P., Vesque C., Schmitt J., Stunnenberg H., Frank R., Charnay P. RT The serum-inducible mouse gene Krox-24 encodes a sequence-specific RT transcriptional activator RL Mol. Cell. Biol. 10:3456-3467 (1990). RN [2] RA Lemaire P., Revelant O., Bravo R., Charnay P. RT Two mouse genes encoding potential transcription factors RT with identical DNA-binding domains are activated by RT growth factors in cultured cells RL Proc. Natl. Acad. Sci. USA 85:4691-4695 (1988). RN [3] RA Gupta M. P., Gupta M., Zak R., Sukhatme V. P. RT Egr-1, a serum-inducible zinc finger protein, regulates RT transcription of the rat cardiac alpha-myosin heavy chain gene RL J. Biol. Chem. 266:12813-12816 (1991). RN [4] RA Sukhatme V. P., Cao X., Chang L. C., Tsai-Morris C.-H., RA Stamenkovich D., Ferreira P. C. P., Cohen D. R., Edwards RA S. A., Shows T. B., Curran T., Le Beau M. M., Adamson E. D. RT A zinc finger-encoding gene coregulated with c-fos RT during growth and differentiation, and after cellular depolarization RL Cell 53:37-43 (1988). RN [5] RA Suva L. J., Ernst M., Rodan G. A. RT Retinoic acid increases zif268 early gene expression RT in rat preosteoblastic cells RL Mol. Cell. Biol. 11:2503-2510 (1991). RN [6] RA Pavletich N. P., Pablo C. O. RT Zinc finger-DNA recognition: Crystal structure of RT a Zif268-DNA complex at 2.1 A RL Science 252:809-816 (1991). XX // AC T00456 XX ID T00456 XX DT 02.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Kr XX SY Krueppel; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.2.1. XX SZ 466 AA XX SQ MSISMLQDAQTRTLAAALAGIKQEDVHLDRSMSLSPPMSANTSATSAAAIYPAMGLQQAA SQ AASAFGMLSPTQLLAANRQAAAFMAQLPMSTLANTLFPHNPAALFGAWAAQQSLPPQGTH SQ LHSPPASPHSPLSTPLGSGKHPLNSPNSTPQHHEPAKKARKLSVKKEFQTEISMSVNDMY SQ LSSGGPISPPSSGSSPNSTHDGAGGNAGCVGVSKDPSRDKSFTCKICSRSFGYKHVLQNH SQ ERTHTGEKPFECPECDKRFTRDHHLKTHMRLHTGEKPYHCSHCDRQFVQVANLRRHLRVH SQ TGERPYTCEICDGKFSDSNQLKSHMLVHTGEKPFECERCHMKFRRRHHLMNHKCGIQSPP SQ TPALSPAMSGDYPVAISAIAIEASTNRFAAMCATYGSSNESVDMEKATPETMVHWICLKM SQ EPALWMAITATSHGARHRTFVGFSGCLHRKSLTYPVICLSKPSQRI XX SC SwissProt #P07247 XX SF 5 zinc finger motifs SF alanine-rich region XX FF transcriptional activator/repressor; FF negatively regulated by Hunchback and Bicoid; FF repressor of eve stripe 2 element; FF repressor of hairy in stripe 6; FF activator of hairy in stripes 3 to 5; FF repressor of engrailed XX MX M00021; I$KR_01 XX BS R00412; DROME$EN_02; Quality: 6; fruit fly, Drosophila melanogaster BS R02486; DROME$EVE_15; Quality: 6; fruit fly, Drosophila melanogaster BS R02488; DROME$EVE_17; Quality: 6; fruit fly, Drosophila melanogaster BS R02493; DROME$EVE_22; Quality: 6; fruit fly, Drosophila melanogaster BS R02497; DROME$EVE_26; Quality: 6; fruit fly, Drosophila melanogaster BS R02499; DROME$EVE_28; Quality: 6; fruit fly, Drosophila melanogaster BS R02501; DROME$EVE_30; Quality: 6; fruit fly, Drosophila melanogaster BS R02609; DROME$HB_02; Quality: 6; fruit fly, Drosophila melanogaster BS R02610; DROME$HB_03; Quality: 6; fruit fly, Drosophila melanogaster BS R02619; DROME$KNI_01; Quality: 6; fruit fly, Drosophila melanogaster BS R02620; DROME$KNI_02; Quality: 6; fruit fly, Drosophila melanogaster BS R02605; KR$CONS_01; Quality: 6 BS R02608; KR$CONS_02; Quality: 6 XX DR EMBL: X03414; DMKR(g). DR SwissProt: P07247; KRUP_DROME. DR PIR: A24566; TWFF. DR Flybase: FBgn0001325; Kr. XX RN [1] RA Rosenberg U. B., Schroeder C., Preiss A., Kienlin RA A., Cote S., Riede I., Jaeckle H. RT Structural homology of the product of the Drosophila RT Krueppel gene with Xenopus transcription factor IIIA RL Nature 319:336-339 (1986). RN [2] RA Schuh R., Aicher W., Gaul U., Cote S., Preiss A., RA Maier D., Seifert E., Nauber U., Schroeder C., Kemler R., Jaeckle H. RT A conserved family of nuclear proteins containing RT structural elements of the finger protein encoded RT by Krueppel, a Drosophila segmentation gene RL Cell 47:1025-1032 (1986). RN [3] RA Stanojevic D., Hoey T., Levine M. RT Sequence-specific DNA-binding activities of the gap RT proteins encoded by hunchback and Krueppel in Drosophila RL Nature 341:331-335 (1989). RN [4] RA Treisman J., Desplan C. RT The products of the Drosophila gap genes hunchback RT and Krueppel bind to the hunchback promoters RL Nature 341:335-337 (1989). RN [5] RA Pankratz M. J., Hoch M., Seifert E., Jaeckle H. RT Krueppel requirement for knirps enhancement reflects RT overlapping gap gene activities in the Drosophila embryo RL Nature 341:337-340 (1989). RN [6] RA Gaul U., Redemann N., Jaeckle H. RT Single amino acid exchanges in the finger domain impair RT the function of the Drosophila gene Krueppel (Kr) RL Proc. Natl. Acad. Sci. USA 86:4599-4603 (1989). RN [7] RA Zuo P., Stanojevic D., Colgan J., Han K., Levine M., Manley J. L. RT Activation and repression of transcription by the RT gap proteins hunchback and Krueppel in cultured Drosophila cells RL Genes Dev. 5:254-264 (1991). RN [8] RA Hoch M., Seifert E., Jaeckle H. RT Gene expression mediated by cis-acting sequences of RT the Krueppel gene in response to the Drosophila morphogens RT bicoid and hunchback RL EMBO J. 10:2267-2278 (1991). RN [9] RA Licht J. D., Grossel M. J., Figge J., Hansen U. M. RT Drosophila Krueppel protein is a transcriptional repressor RL Nature 346:76-79 (1990). RN [10] RA Huelskamp M., Pfeifle C., Tautz D. RT A morphogenetic gradient of hunchback protein organizes RT the expression of the gap genes Krueppel and knirps RT in the early Drosophila embryo RL Nature 346:577-580 (1990). RN [11] RA Jacob Y., Sather S., Martin J. R., Ollo R. RT Analysis of Krueppel control elements reveals that RT localized expression results from the interaction of multiple subelements RL Proc. Natl. Acad. Sci. USA 88:5912-5916 (1991). RN [12] RA Sauer F., Jaeckle H. RT Concentration-dependent transcriptional activation RT or repression by Krueppel from a single binding site RL Nature 353:563-566 (1991). RN [13] RA Small S., Kraut R., Hoey T., Warrior R., Levine M. RT Transcriptional regulation of a pair-rule stripe in Drosophila RL Genes Dev. 5:827-839 (1991). RN [14] RA Stanojevic D., Small S., Levine M. RT Regulation of segmentation stripe by overlapping activators RT and repressors in the Drosophila embryo RL Science 254:1385-1387 (1991). RN [15] RA Riddihough G., Ish-Horowicz D. RT Individual stripe regulatory elements in the Drosophila RT hairy promoter respond to maternal, gap, and pair-rule genes RL Genes Dev. 5:840-854 (1991). XX // AC T00457 XX ID T00457 XX DT 10.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA KUP XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; . XX SZ 433 AA XX SQ MDTASHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQTSEC SQ IKIQPTDIQPDIFSYLLHIMYTGKGPKQIVDHSRLEEGIRFLHADYLSHIATEMNQVFSP SQ ETVQSSNLYGIQISTTQKTVVKQGLEVKEAPSSNSGNRAAVQGDLPQLSLAIGLDDGTAD SQ QQRACPATQALEEHQKPPVSIKQERCDPESVISQSHPSPSSEVTGPTFTENSVKIHLCHY SQ CGERFDSRSNLRQHLHTHVSGSLPFGVPASILESNDLGEVHPLNENSEALECRRLSSFIV SQ KENEQQPDHTNRGTTEPLQISQVSLISKDTEPVELNCNFSFSRKRKMSCTICGHKFPRKS SQ QLLEHMYTHKGKSYRYNRCQRFGNALAQRFQPYCDSWSDVSLKSSRLSQEHLDLPCALES SQ ELTQENVDTILVE XX SC SwissProt #P24278 XX SF 1+1 zinc finger motifs XX CP hematopoietic cells, testis XX DR EMBL: X16576; HSKUPMR(r). DR SwissProt: P24278; ZN46_HUMAN. DR PIR: S15647; S15647. XX RN [1] RA Chardin P., Courtois G., Mattei M.-G., Gisselbrecht S. RT The KUP gene, located on human chromosome 14, encodes RT a protein with two distant zinc fingers RL Nucleic Acids Res. 19:1431-1436 (1991). XX // AC T00458 XX ID T00458 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA LAC9 XX SY K1GAL4; LA1C9; XX OS yeast, Kluyveromyces lactis OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0005; C6; . XX SZ 97 kDa XX SQ MGSRASNSPSFSSKAETLLPSEYKKNAVKKETIRNGKKRKLPDTESSDPEFASRRLIANE SQ TGTDAVSNGNKNDSNANNNNNNNNKKSSEVMHQACDACRKKKWKCSKTVPTCTNCLKYNL SQ DCVYSPQVVRTPLTRAHLTEMENRVAELEQFLKELFPVWDIDRLLQQKDTYRIRELLTMG SQ STNTVPGLASNNIDSSLEQPVAFGTAQPAQSLSTDPAVQSQAYPMQPVPMTELQSITNLR SQ HTPSLLDEQQMNTISTATLRNMYSSGNNNNNLGNISGLSPVTEAFFRWQEGETSIDNSYF SQ GKGSILFWLNQLLSSEKIAGVTSKVGNDINTNNNNINHQKLPLILNNNITHNVSDITTTS SQ TSSNKRAMSPLSANDSVYLAKRETISAYIDAYFKHYHALYPLVSKEMFFAQYNDQIKPEN SQ VEIWHILLNAVLALGSWCSNSCSSHHTLYYQNALSYLSTAVLETGSTDLTIALILLTHYV SQ QKMHKPNTAWSLIGLCSHMATSLGLHRDLPNSTIHDQQLRRVLWWTIYCTGCDLSLETGR SQ PSLLPNLQAIDIPLPASSATIKEPSIYSSIIQESQWSQILQQKLSNNSYQQSAGECLSWF SQ DSVQAFLDHWPTPSTEAELKALNETQLDWLPLVKFRPYWMFHCSLISLFSVFFEEDAPTD SQ NNVIRCKELCLQLSSRNIFSVATFVRSYAFNSLSCWYATHYLVRSALVPLHFASRISPQH SQ ALWETVKAQLLSAHEAMGILSQESSLAAKFDGILTKNYSEILQREGINKSQLMPPPTPLL SQ QSTSFSDLLSLWSANAEDAPRVSNSQMPQSITITDSLLQSSTTQMRPPTTSGWPDTNNFL SQ NPSTQQLFNTTTMDDVYNYIFDNDE XX SC SwissProt #P08657 XX FF activator of genes required for lactose and galactose utilization XX IN T00303; GAL80; yeast, Saccharomyces cerevisiae. IN T01267; GAL80; yeast, Kluyveromyces lactis. XX MX M00207; F$LAC9_C XX BS R03056; AS$LAC09; Quality: 6 BS R04130; KLULA$LAC12_01; Quality: 1; yeast, Kluyveromyces lactis BS R04131; KLULA$LAC12_02; Quality: 1; yeast, Kluyveromyces lactis BS R00962; KLULA$LAC4_01; Quality: 1; yeast, Kluyveromyces lactis BS R04129; KLULA$LAC4_02; Quality: 1; yeast, Kluyveromyces lactis BS R00489; Y$GAL1_04; Quality: 1; yeast, Saccharomyces cerevisiae XX DR EMBL: M15210; KLLAC9(g). DR EMBL: X06215; KLLAC9A(g). DR EMBL: X17249; KLLAC9ZF(g). DR SwissProt: P08657; LAC9_KLULA. DR PIR: A25762; A25762. DR PIR: S08482; S08482. XX RN [1] RA Breunig K. D., Kuger P. RT Functional Homology between the Yeast Regulatory Proteins RT GAL4 and LAC9: LAC9-Mediated Transcriptional Activation RT in Kluyveromyces lactis Involves Protein Binding to RT a Regulatory Sequence Homologous to the GAL4 Protein-Binding Site RL Mol. Cell. Biol. 7:4400-4406 (1987). RN [2] RA Zachariae W., Kuger P., Breunig K. D. RT Glucose repression of lactose/galactose metabolism RT in Kluyveromyces lactis is determined by the concentration RT of the transcriptional activator LA1C9 (K1GAL4) RL Nucleic Acids Res. 21:69-77 (1993). RN [3] RA Wray jr. L. V., Witte M., Dickson R. C., Riley M. I. RT Characterization of a positive regulatory gene, LAC9, RT that controls induction of the lactose-galactose regulon RT of Kluyveromyces lactis: structural and functional RT relationships to GAL4 of Saccharomyces cerevisiae RL Mol. Cell. Biol. 7:1111-1121 (1987). RN [4] RA Salmeron jr. J. M., Johnston S. A. RT Analysis of the Kluyveromyces lactis positive regulatory RT gene LAC9 reveals functional homology to, but sequence RT divergence from, the Saccharomyces cerevisiae GAL4 gene RL Nucleic Acids Res. 14:7767-7781 (1986). RN [5] RA Salmeron J. M., Langdon S. D., Johnston S. A. RT Interaction between Transcriptional Activator Protein RT LAC9 and Negative Regulatory Protein GAL80 RL Mol. Cell. Biol. 9:2950-2956 (1989). RN [6] RA Halvorsen Y.-D. C., Nandabalan K., Dickson R. C. RT Identification of base and backbone contacts used RT for DNA sequence recognition and high-affinity binding RT by LAC9, a transcription activator containing C6 zinc finger RL Mol. Cell. Biol. 11:1777-1784 (1991). XX // AC T00459 XX ID T00459 XX DT 23.03.93 (created); ewi. DT 03.03.97 (updated); ewi. XX FA C/EBPbeta XX SY AGP/EBP (mouse); ANF-2; CRP2; H-APF-2; IL-6DBP; LAP; LAP1; NF-IL6; NF-M; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0008; bZIP; 1.1.3.0.2.1. XX SZ 297 AA; 31.5 kDa (cDNA), 38 kDa (SDS) XX SQ MHRLLAWDAACLPPPPAAFRPMEVANFYYEPDCLAYGAKAARAAPRAPAAEPAIGEHERA SQ IDFSPYLEPLAPAAADFAAPAPAHHDFLSDLFADDYGAKPSKKPSDYGYVSLGRAGAKAA SQ PPACFPPPPPAALKAEPGFEPADCKRADDAPAMAAGFPFALRAYLGYQATPSGSSGSLST SQ SSSSSPPGTPSPADAKAAPAACFAGPPAAPAKAKAKKAVDKLSDEYKMRRERNNIAVRKS SQ RDKAKMRNLETQHKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASAGHC XX SC SwissProt #P21272 XX FT 251 286 leucine zipper (TL5) FT 153 297 alternative translation product (LIP) [6]; FT 13 21 proline-rich region (5/9) FT 22 297 alternative translation product (p34) [6]; FT 22 93 trans-activation domain [10]; FT 22 31 activation module 1 (ADM1) [10]; FT 54 72 activation module 2 (ADM2) [10]; FT 84 93 activation module 3 (ADM3) [10]; FT 99 105 potential cAMP-dependent phosphorylation site (KPSKKPS) FT 121 130 proline-rich region (7/10) FT 137 212 regulatory domain [10]; FT 137 170 regulatory domain 1 (RD1) [10]; FT 184 212 regulatory domain 2 (RD2) [10]; FT 172 191 serine-rich region (11/20) FT 214 247 basic region XX SF alternative translation initiation at Met-153 gives SF rise to LIP (T01429) [6], [12], and initiation at Met-22 to p34 [6]; SF half-saturation DNA-binding at 0.71 nM [6]; SF C/EBPbeta may adopt a tightly folded conformation SF masking its trans-activating and the DNA-binding domain [10]; XX CP liver (high); muscle, heart, thyroid, lung; less in CP spleen, gut, kidney, stomach [14], [15]; CN thymus, brain, testis [14], [15]; XX FF activator [14], [15]; FF involved in acute phase reactions, inflammation and FF haematopoiesis, may be a master gene of these responses [14], [7]; FF increases the transcriptional stimulation by glucocorticoids [8]; FF ectopic expression is sufficient for IL-6 expression FF after induction by LPS [9]; FF transcripts accumulate in lung, liver, spleen, kidney, brain, testis; FF Ser-105 phosphorylation may be by PKC [5]; FF can be induced in PC12 cells by forskolin, leading FF to association with a pp43 and a p64; FF also induced by IL-1, IL-6, LPS [14]; FF XX IN T00051; ATF; human, Homo sapiens. IN T00104; C/EBPalpha; mouse, Mus musculus. IN T00105; C/EBPalpha; human, Homo sapiens. IN T00106; C/EBP; fruit fly, Drosophila melanogaster. IN T00107; C/EBPalpha; chick, Gallus gallus. IN T00108; C/EBPalpha; rat, Rattus norvegicus. IN T00109; C/EBPdelta; rat, Rattus norvegicus. IN T00127; CHOP-10; mouse, Mus musculus. IN T00171; C/EBPepsilon; rat, Rattus norvegicus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. IN T00583; C/EBPdelta; human, Homo sapiens. IN T01114; C/EBPdelta; mouse, Mus musculus. IN T01303; CREB-2; human, Homo sapiens. IN T01386; C/EBP; Aplysia, Aplysia californica. IN T01388; C/EBP; clawed frog, Xenopus laevis. IN T01420; LIP; rat, Rattus norvegicus. XX MX M00109; V$CEBPB_01 MX M00117; V$CEBPB_02 XX BS R00207; AS$CEBP_01; Quality: 6 BS R03251; HS$ADH1_07; Quality: 1; human, Homo sapiens BS R03128; HS$ADH2_03; Quality: 2; human, Homo sapiens BS R03243; HS$ADH3_09; Quality: 2; human, Homo sapiens BS R00464; HS$CFOS_07; Quality: 6; human, Homo sapiens BS R04047; HS$CFOS_19; Quality: 2; human, Homo sapiens BS R03152; HS$HPX_01; Quality: 2; human, Homo sapiens BS R00089; MOUSE$ALBU_08; Quality: 2; mouse, Mus musculus BS R02216; NFIL6$CONS; Quality: 6 BS R00097; RAT$ALBU_21; Quality: 6; rat, Rattus norvegicus BS R01358; RAT$SSTA_01; Quality: 6; rat, Rattus norvegicus BS R01344; RSV$RSV_04; Quality: 6; RSV, rous sarcoma virus XX DR EMBL: M84011; RNCRP2A(g). DR EMBL: M57235; RNIL6DPB(r). DR EMBL: X54626; RNLAPG(g). DR EMBL: S77528; S77528(g). DR SwissProt: P21272; CEBB_RAT. DR PIR: A35914; A35914. DR PIR: A36197; A36197. DR Compel: C00070 DR Compel: C00078 XX RN [1] RA Metz R., Ziff E. RT cAMP stimulates the C/EBP-related transcription factor RT rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription RL Genes Dev. 5:1754-1766 (1991). RN [2] RA Lichtsteiner S., Wuarin J., Schibler U. RT The Interplay of DNA-Binding Proteins on the Promoter RT of the Mouse Albumin Gene RL Cell 51:963-973 (1987). RN [3] RA Vinson C. R., Hai T., Boyd S. M. RT Dimerization specificity of the leucine zipper-containing RT bZIP motif on DNA binding: prediction and rational design RL Genes Dev. 7:1047-1058 (1993). RN [4] RA Metz R., Ziff E. RT The helix-loop-helix protein rE12 and the C/EBP-related RT factor rNFIL-6 bind to neighboring sites within the RT c-fos serum response element RL Oncogene 6:2165-2178 (1991). RN [5] RA Trautwein C., Caelles C., van der Geer P., Hunter T., Karin M., Chojkier M. RT Transactivation by NF-IL6/LAP is enhanced by phosphorylation RT of its activation domain RL Nature 364:544-547 (1993). RN [6] RA Descombes P., Schibler U. RT A liver-enriched transcriptional activator protein, RT LAP, and a transcriptional inhibitory protein, LIP, RT are translated from the same mRNA RL Cell 67:569-579 (1991). RN [7] RA Poli V., Cortese R. RT Interleukin 6 induces a liver-specific nuclear protein RT that binds to the promoter of acute-phase genes RL Proc. Natl. Acad. Sci. USA 86:8202-8206 (1989). RN [8] RA Baumann H., Morella K. K., Campos S. P., Cao Z., Jahreis G. P. RT Role of CAAT-enhancer binding protein isoforms in RT the cytokine regulation of acute-phase plasma protein genes RL J. Biol. Chem. 267:19744-19751 (1992). RN [9] RA Bretz J. D., Williams S. C., Baer M., Johnson P. F., Schwartz R. C. RT C/EBP-related protein 2 confers lipopolysaccharide-inducible RT expression of interleukin 6 and monocyte chemoattractant RT protein 1 to a lymphoblastic cell line RL Proc. Natl. Acad. Sci. USA 91:7306-7310 (1994). RN [10] RA Williams S. C., Baer M., Dillner A. J., Johnson P. F. RT CRP2 (C/EBPbeta) contains a bipartite regulatory domain RT that controls transcriptional activation, DNA bindģng and cell specificity RL EMBO J. 14:3170-3183 (1995). RN [11] RA Maire P., Wuarin J., Schibler U. RT The Role of Cis-Acting Promoter Elements in Tissue-Specific RT Albumin Gene Expression RL Science 244:343-346 (1989). RN [12] RA Ossipow V., Descombes P., Schibler U. RT CCAAT/enhancer-binding protein mRNA is translated RT into multiple proteins with different transcription activation potentials RL Proc. Natl. Acad. Sci. USA 90:8219-8223 (1993). RN [13] RA Williams S. C., Cantwell C. A., Johnson P. F. RT A family of C/EBP-related proteins capable of forming RT covalently linked leucine zipper dimers in vitro RL Genes Dev. 5:1553-1567 (1991). RN [14] RA Poli V., Mancini F. P., Cortese R. RT IL-6DBP, a nuclear protein involved in interleukin-6 RT signal transduction, defines a new family of leucine RT zipper proteins related to C/EBP RL Cell 63:643-653 (1990). RN [15] RA Descombes P., Chojkier M., Lichtsteiner S., Falvey E., Schibler U. RT LAP, a novel member of the C/EBP gene family, encodes RT a liver-enriched transcriptional activator protein RL Genes Dev. 4:1541-1551 (1990). RN [16] RA Williams P., Ratajczak T., Lee S. C., Ringold G. M. RT AGP/EBP(LAP) expressed in rat hepatoma cells interacts RT with multiple promoter sites and is necessary for RT maximal glucocorticoid induction of the rat alpha-1 acid glycoprotein gene RL Mol. Cell. Biol. 11:4959-4965 (1991). XX // AC T00460 XX ID T00460 XX DT 15.10.92 (created); ewi. XX FA LBP XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R02191; LBP$CONS; Quality: 6 BS R01789; MOMLV$MOMULV_16; Quality: 6; Mo-MuLV, moloney murine leukemia virus XX RN [1] RA Tsukiyama T., Niwa O., Yokoro K. RT Mechanism of Suppression of the Long Terminal Repeat RT of Moloney Leukemia Virus in Mouse Embryonal Carcinoma Cells RL Mol. Cell. Biol. 9:4670-4676 (1989). XX // AC T00461 XX ID T00461 XX DT 03.12.92 (created); ewi. XX FA LBP-1 XX SY UBP-1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF repressor; FF binds to two sites around the HIV transcription initiation site; FF site II overlaps with TATA box, LBP-1 binding precludes FF TFIID from binding to the TATA box XX BS R03168; HIV1$HIV1_18; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R03169; HIV1$HIV1_19; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R02632; HIV2$HIV2_02; Quality: 6; HIV-2, human immunodeficiency virus type 2 BS R02633; HIV2$HIV2_03; Quality: 6; HIV-2, human immunodeficiency virus type 2 XX RN [1] RA Toohey M. G., Jones K. A. RT In vitro formation of short RNA polymerase II transcripts RT that terminate within the HIV-1 and HIV-2 promoter-proximal RT downstream regions RL Genes Dev. 3:265-282 (1989). RN [2] RA Kato H., Horikoshi M., Roeder R. G. RT Repression of HIV-1 transcription by a cellular protein RL Science 251:1476-1479 (1991). XX // AC T00462 XX ID T00462 XX DT 15.10.92 (created); ewi. XX FA LBP-1 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX BS R01620; CHICK$STN1_01; Quality: 6; chick, Gallus gallus BS R01621; CHICK$STN1_02; Quality: 6; chick, Gallus gallus BS R01622; CHICK$STN1_03; Quality: 6; chick, Gallus gallus XX RN [1] RA Nikovits jr. W., Mar J. H., Ordahl C. P. RT Muscle-Specific Activity of the Skeletal Troponin RT I Promoter Requires Interaction between Upstream Regulatory RT Sequences and Elements Contained within the First Transcribed Exon RL Mol. Cell. Biol. 10:3468-3482 (1990). XX // AC T00463 XX ID T00463 XX DT 22.10.92 (created); ewi. DT 14.02.97 (updated); ewi. XX FA Lc XX OS maize, Zea mays OC eukaryota; plantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX CL C0011; HLH; 1.2.0.0.2. XX SZ 610 AA; 66.3 kDa (cDNA) XX SQ MALSASRVQQAEELLQRPAERQLMRSQLAAAARSINWSYALFWSISDTQPGVLTWTDGFY SQ NGEVKTRKISNSVELTSDQLVMQRSDQLRELYEALLSGEGDRRAAPARPAGSLSPEDLGD SQ TEWYYVVSMTYAFRPGQGLPGRSFASDEHVWLCNAHLAGSKAFPRALLAKSASIQSILCI SQ PVMGGVLELGTTDTVPEAPDLVSRATAAFWEPQCPSSSPSGRANETGEAAADDGTFAFEE SQ LDHNNGMDDIEAMTAAGGHGQEEELRLREAEALSDDASLEHITKEIEEFYSLCDEMDLQA SQ LPLPLEDGWTVDASNFEVPCSSPQPAPPPVDRATANVAADASRAPVYGSRATSFMAWTRS SQ SQQSSCSDDAAPAAVVPAIEEPQRLLKKVVAGGGAWESCGGATGAAQEMSGTGTKNHVMS SQ ERKRREKLNEMFLVLKSLLPSIHRVNKASILAETIAYLKELQRRVQELESSREPASRPSE SQ TTTRLITRPSRGNNESVRKEVCAGSKRKSPELGRDDVERPPVLTMDAGTSNVTVTVSDKD SQ VLLEVQCRWEELLMTRVFDAIKSLHLDVLSVQASAPDGFMGLKIRAQFAGSGAVVPWMIS SQ EALRKAIGKR XX SC SwissProt #P13526 XX FT 425 462 helix-loop-helix domain FT 188 318 acidic region (33/131) FT 415 424 basic region XX CP midrip, ligule, auricle, glume, lemma, palea, pericarp [1]; XX FF regulates genes of the anthocyanin biosynthesis [3]; FF Lc expression is under translational control: repression FF is achieved by a short upstream ORF of 38 codons [2]; XX DR EMBL: M26227; ZMREGG(r). DR SwissProt: P13526; ARLC_MAIZE. DR PIR: A41388; A41388. XX RN [1] RA Ludwig S. R., Wessler S. R. RT Maize R gene family: tissue-specific helix-loop-helix proteins RL Cell 62:849-851 (1990). RN [2] RA R. D. Damiani jr., Wessler S. R. RT An upstream open reading frame represses expression RT of Lc, a member of the R/B family of maize transcriptional activators RL Proc. Natl. Acad. Sci. USA 90:8244-8248 (1993). RN [3] RA Ludwig S. R., Habera L. F., Dellaporta S. L., Wessler S. R. RT Lc, a member of the maize R gene family responsible RT for tissue-specific anthocyanin production, encodes RT a protein similar to transcriptional activators and RT contains the myc-homology region RL Proc. Natl. Acad. Sci. USA 86:7092-7096 (1989). XX // AC T00465 XX ID T00465 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA LEU3 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0005; C6; 2.4.1.0.6. XX SZ 886 AA XX SQ MEGRSDFVATSQSGSEMSHSETRNRTGMNARKRKFACVECRQQKSKCDAHERAPEPCTKC SQ AKKNVPCILKRDFRRTYKRARNEAIEKRFKELTRTLTNLTSDEILKKIEEEQEIVLDNSN SQ FTKEKVKQLRKSAFETTEIEPRSYKTLRGEPISYSTNRRHTDSSPLTLLSSSTNFDPVHS SQ TNVMTDDQLKCLPKSLGDVYLSSSDIAELFQEFATKYHQFLPVVDLSKGAERIYHLSPCL SQ FWVILLIGLRRKFGATDLMTRLSVLVKSVLSEITISPIIRYTPSDKDEPVLNVASVYSVQ SQ AFLLYTFWPPLTSSLSADTSWNTIGTAMFQALRVGLNCAGFSKEYASANSELVNEQIRTW SQ ICCNVVSQTVASSFGFPAYVSFDYLVISSIRVPNSKSQVDIPNELRQMAQIARFENQIVN SQ TMNSTPASVTGMVSQEEKQPLLHVLNQQLSQLEISLEENNLDDIRKFLLLVAKVHLLTYY SQ FTDVTSQSAGKSNGNIYEGSYSIMELDTSFETKRGLVKVYNAAVNFLIHANSMWEHDPTI SQ IKYFPGLFVLNIWQSACIISKLIHSSLHSMLDVNSGKKAYNNAISLTFNASVLKYDMAYR SQ SSGIMRSIWSLFANMYDAWKNDQKEGGGRLNNDFNLGITIKSRMSVNVFFDCLYILKEKC SQ GMAKLERETKVSTAYNVDEEEEEDEDEEGEEEEEEEELSSKVPENMDSQQLRTRKFTNVR SQ HPEKKARKIIETIPLDPNPINAGSTSSGSSLTTPNSQVANTISYRGILNKMSPREQLNHA SQ NLDSSVSTDIKDTEAVNEPLPIGRNAEHPANQPPLSITQMQENTLPATQANSSLLETYPI SQ VQSNPVTTTIKESPNSIMAGWDNWESDMVWRDVDILMNEFAFNPKV XX SC SwissProt #P08638 XX FT 23 34 basic region FT 37 67 zinc-cystein cluster FT 70 81 basic region FT 85 99 heptad repeats FT 109 117 acidic region XX FF activator or repressor, depending on the presence / absence of alpha-IPM; FF regulates biosynthesis of branched amino acids XX BS R00969; Y$LEU2_01; Quality: 1; yeast, Saccharomyces cerevisiae XX DR EMBL: M17222; SCLEU(g). DR EMBL: Y00360; SCLEU3(g). DR SwissProt: P08638; LEUR_YEAST. DR PIR: S00638; RGBYL3. XX RN [1] RA Sze J.-Y., Remboutsika E., Kohlhaw G. B. RT Transcriptional regulator Leu3 of Saccharomyces cerevisiae: RT separation of activator and repressor functions RL Mol. Cell. Biol. 13:5702-5709 (1993). RN [2] RA Friden P., Reynolds C., Schimmel P. RT A Large Internal Deletion Converts Yeast LEU3 to a RT Constitutive Transcriptional Activator RL Mol. Cell. Biol. 9:4056-4060 (1989). XX // AC T00466 XX ID T00466 XX DT 26.01.93 (created); hse. DT 14.05.94 (updated); ewi. XX FA LF-A1 XX SY AID1; HNF-2; LFA1; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX HO NF-BA1 XX SZ 40 kDa (SDS, GF) XX CP liver XX BS R00155; CHICK$APOVLDL_03; Quality: 4; chick, Gallus gallus BS R00157; CHICK$APOVLDL_05; Quality: 4; chick, Gallus gallus BS R02192; LFA1$CONS; Quality: 6 XX RN [1] RA Ramji D. P., Tadros M. H., Hardon E. M., Cortese R. RT The transcription factor LF-A1 interacts with a bipartite RT recognition sequence in the promoter regions of several liver-specific genes RL Nucleic Acids Res. 19:1139-1146 (1991). XX // AC T00467 XX ID T00467 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); hwi; hse; ewi. XX FA LF-A1 XX SY AID1; HNF-2; LFA1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO NF-BA1 XX CP liver XX FF different from Tf-LF1/2 XX BS R00135; HS$APOA1_01; Quality: 6; human, Homo sapiens BS R03662; HS$APOB_11; Quality: 6; human, Homo sapiens BS R02192; LFA1$CONS; Quality: 6 BS R01171; RAT$NF1_01; Quality: 6; rat, Rattus norvegicus XX DR EMBL: Z22804; HSLFA1A(g). XX RN [1] RA Ochoa A., Brunel F., Mendelzon D., Cohen G. N., Zakin M. M. RT Different liver nuclear proteins bind to similar sequences RT in the 5' flanking regions of three hepatic genes RL Nucleic Acids Res. 17:119-133 (1989). RN [2] RA Ramji D. P., Tadros M. H., Hardon E. M., Cortese R. RT The transcription factor LF-A1 interacts with a bipartite RT recognition sequence in the promoter regions of several liver-specific genes RL Nucleic Acids Res. 19:1139-1146 (1991). XX // AC T00468 XX ID T00468 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); hse; ewi. XX FA LF-A1 XX SY AID1; HNF-2; LFA1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO NF-BA1 XX CP (liver) XX BS R00114; HS$A1ANTR_01; Quality: 2; human, Homo sapiens BS R00115; HS$A1ANTR_02; Quality: 6; human, Homo sapiens BS R00116; HS$A1ANTR_03; Quality: 6; human, Homo sapiens BS R02192; LFA1$CONS; Quality: 6 XX RN [1] RA Hardon E. M., Frain M., Paonessa G., Cortese R. RT Two distinct factors interact with the promoter regions RT of several liver-specific genes RL EMBO J. 7:1711-1719 (1988). RN [2] RA Li Y., Shen R.-F., Tsai S. Y., Woo S. L. C. RT Multiple Hepatic trans-Acting Factors Are Required RT for In Vitro Transcription of the Human Alpha-1-Antitrypsin Gene RL Mol. Cell. Biol. 8:4362-4369 (1988). RN [3] RA Monaci P., Nicosia A., Cortese R. RT Two different liver-specific factors stimulate in RT vitro transcription from the human alpha1-antitrypsin promoter RL EMBO J. 7:2075-2087 (1988). RN [4] RA Lucero M. A., Sanchez D., Ochoa A. R., Brunel F., RA Cohen G. N., Baralle F. E., Zakin M. M. RT Interaction of DNA-binding proteins with the tissue-specific RT human apolipoprotein-AII enhancer RL Nucleic Acids Res. 17:2283-2300 (1989). RN [5] RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., RA Monaci P., Cladaras C., Zannis V. I. RT Promoter elements and factors involved in hepatic RT transcription of the human ApoA-I gene positive and RT negative regulators bind to overlapping sites RL J. Biol. Chem. 266:5790-5797 (1991). RN [6] RA Ramji D. P., Tadros M. H., Hardon E. M., Cortese R. RT The transcription factor LF-A1 interacts with a bipartite RT recognition sequence in the promoter regions of several liver-specific genes RL Nucleic Acids Res. 19:1139-1146 (1991). RN [7] RA Rangan V. S., Das G. C. RT Purification and Biochemical Characterization of Hepatocyte RT Nuclear Factor 2 Involved in Liver-specific Transcription RT of the Human alpha1-Antitrypsin Gene RL J. Biol. Chem. 265:8874-8879 (1990). XX // AC T00469 XX ID T00469 XX DT 15.10.92 (created); ewi. XX FA LF-A2 XX SY LFA2; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00117; HS$A1ANTR_04; Quality: 6; human, Homo sapiens XX RN [1] RA Monaci P., Nicosia A., Cortese R. RT Two different liver-specific factors stimulate in RT vitro transcription from the human alpha1-antitrypsin promoter RL EMBO J. 7:2075-2087 (1988). XX // AC T00470 XX ID T00470 XX DT 15.10.92 (created); ewi. XX FA LF-B2 XX SY LFB2; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00119; HS$A1ANTR_06; Quality: 6; human, Homo sapiens XX RN [1] RA Monaci P., Nicosia A., Cortese R. RT Two different liver-specific factors stimulate in RT vitro transcription from the human alpha1-antitrypsin promoter RL EMBO J. 7:2075-2087 (1988). XX // AC T00472 XX ID T00472 XX DT 15.10.92 (created); ewi. XX FA LF-C XX SY LFC; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00124; HS$A1ANTR_11; Quality: 6; human, Homo sapiens XX RN [1] RA Monaci P., Nicosia A., Cortese R. RT Two different liver-specific factors stimulate in RT vitro transcription from the human alpha1-antitrypsin promoter RL EMBO J. 7:2075-2087 (1988). XX // AC T00473 XX ID T00473 XX DT 26.01.93 (created); hse. XX FA LIT-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 200 kDa (GF) XX FF acts on apolipoprotein B gene promoter XX BS R02194; LIT1$CONS; Quality: 6 XX RN [1] RA Carlsson P., Erikson P., Bjursell G. RT Two nuclear proteins bind to the major positive element RT of the apolipoprotein B gene promoter RL Gene 94:295-301 (1990). XX // AC T00474 XX ID T00474 XX DT 15.10.92 (created); ewi. DT 16.03.94 (updated); hwi; hse. XX FA LSF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 63 kDa (SDS) XX CP (HeLa) XX FF similar to, but different from Sp1 XX BS R02195; LSF$CONS; Quality: 6 BS R01373; SV$SV40_05; Quality: 6; SV40, simian virus 40 BS R01374; SV$SV40_06; Quality: 6; SV40, simian virus 40 BS R01421; SV$SV40_53; Quality: 6; SV40, simian virus 40 XX RN [1] RA Kim C. H., Heath C., Bertuch A., Hansen U. RT Specific stimulation of simian virus 40 late transcription RT in vitro by a cellular factor binding the simian virus RT 40 21-base-pair repeat promoter element RL Proc. Natl. Acad. Sci. USA 84:6025-6029 (1987). RN [2] RA Huang H.-C., Sundseth R., Hansen U. RT Transcription factor LSF binds two variant bipartite RT sites within the SV40 late promoter RL Genes Dev. 4:287-298 (1990). XX // AC T00475 XX ID T00475 XX DT 15.10.92 (created); ewi. XX FA LVa XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01134; MOMLV$MOMULV_01; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R01135; MOMLV$MOMULV_02; Quality: 6; Mo-MuLV, moloney murine leukemia virus XX RN [1] RA Speck N. A., Baltimore D. RT Six distinct nuclear factors interact with the 75-base-pair RT repeat of the moloney murine leukemia virus enhancer RL Mol. Cell. Biol. 7:1101-1110 (1987). XX // AC T00476 XX ID T00476 XX DT 15.10.92 (created); ewi. XX FA LVb-binding factor XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX BS R01656; FELV$FELV_01; Quality: 6; FeLV, feline leukemia virus XX RN [1] RA Fulton R., Plumb M., Shield L., Neil J. C. RT Structural Diversity and Nuclear Protein Binding Sites RT in the Long Terminal Repeats of Feline Leukemia Virus RL J. Virol. 64:1675-1682 (1990). XX // AC T00477 XX ID T00477 XX DT 15.10.92 (created); ewi. XX FA LVb-binding factor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01656; FELV$FELV_01; Quality: 6; FeLV, feline leukemia virus BS R01138; MOMLV$MOMULV_05; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R01139; MOMLV$MOMULV_06; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R01642; RADLV$RLV_01; Quality: 6; RadLV (BL/VL3 Kaplan radiation leukemia virus) BS R01646; RADLV$RLV_05; Quality: 6; RadLV (BL/VL3 Kaplan radiation leukemia virus) XX RN [1] RA Speck N. A., Baltimore D. RT Six distinct nuclear factors interact with the 75-base-pair RT repeat of the moloney murine leukemia virus enhancer RL Mol. Cell. Biol. 7:1101-1110 (1987). RN [2] RA Gorska-Flipot I., Jolicoeur P. RT DNA-Binding Proteins That Interact with the Long Terminal RT Repeat of Radiation Leukemia Virus RL J. Virol. 64:1566-1572 (1990). XX // AC T00478 XX ID T00478 XX DT 15.10.92 (created); ewi. XX FA LVc XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01142; MOMLV$MOMULV_09; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R01143; MOMLV$MOMULV_10; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R01644; RADLV$RLV_03; Quality: 6; RadLV (BL/VL3 Kaplan radiation leukemia virus) XX RN [1] RA Speck N. A., Baltimore D. RT Six distinct nuclear factors interact with the 75-base-pair RT repeat of the moloney murine leukemia virus enhancer RL Mol. Cell. Biol. 7:1101-1110 (1987). RN [2] RA Gorska-Flipot I., Jolicoeur P. RT DNA-Binding Proteins That Interact with the Long Terminal RT Repeat of Radiation Leukemia Virus RL J. Virol. 64:1566-1572 (1990). XX // AC T00479 XX ID T00479 XX DT 26.01.93 (created); hse. DT 27.10.93 (updated); ewi. XX FA LyF-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 2.3.2.2.9. XX SZ 50 kDa (SDS) XX CP B, T cells XX FF may be a member of the Ets family XX MX M00141; V$LYF1_01 XX BS R00874; HS$IGH_03; Quality: 1; human, Homo sapiens BS R03518; HS$LCK_01; Quality: 1; human, Homo sapiens BS R03519; HS$LCK_02; Quality: 1; human, Homo sapiens BS R02196; LYF1$CONS; Quality: 6 BS R02685; MOUSE$IGH_47; Quality: 1; mouse, Mus musculus BS R02982; MOUSE$IGKL_24; Quality: 5; mouse, Mus musculus BS R03509; MOUSE$IGLL_02; Quality: 1; mouse, Mus musculus BS R03510; MOUSE$IGLL_03; Quality: 1; mouse, Mus musculus BS R03512; MOUSE$IGLL_05; Quality: 1; mouse, Mus musculus BS R03513; MOUSE$IGLL_06; Quality: 1; mouse, Mus musculus BS R03503; MOUSE$TDT_02; Quality: 1; mouse, Mus musculus BS R03504; MOUSE$TDT_03; Quality: 1; mouse, Mus musculus XX RN [1] RA Lo K., Landau N. R., Smale S. T. RT LyF-1, a transcriptional regulator that interacts RT with a novel class of promoters for lymphocytes-specific genes RL Mol. Cell. Biol. 11:5229-5243 (1991). XX // AC T00480 XX ID T00480 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA MAL63 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0005; C6; 2.4.1.0.5. XX SQ MGIAKQSCDCCRVRRVKCDRNKPCNRCIQRNLNCTYLQPLKKRGPKSIRAGSLKKIAEVQ SQ MVSMNNNIMAAPVVCKKVPKNLIDQCLRLRLYHDNLYVIWPMLSYDDLHKLLEEKYDDRC SQ AYWFLVSLSAATLSDLQIEIEYEEGVTFTGEQLCTLCMLSRQFFDDLSNSDIFRIMTYYC SQ LHRCYAQFADTRTSYRLSCEAVGLIIKIAGFHREETYEFLPFGEQQLRRKVYYLLLMTER SQ FYAVYIKCVTSLDATIAPPLPEVVTDPRLSLESFLEVIRVFTIPGKCFYDALATNCVDDS SQ CTEDSLKRIRNELHTTSLDIEPWSYGYIDFLFSRHWVRTLAWKLVLHMKGMRMNFLSNTN SQ NTHIPVEIARDMLGDTFLTPKNLYDVHGPGIPMKALEIANALVDVVNKYDHNMKLEAWNV SQ LYDVSKFVFSLKHCNNKMFDRFSTKCQGALITLPISKPLQLNDNSKDEDDIIP XX SC SwissProt #P10508 XX FF activator of maltose fermentation genes XX BS R01632; Y$MAL61_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R01633; Y$MAL61_02; Quality: 4; yeast, Saccharomyces cerevisiae XX DR EMBL: M36537; SCMAL63(g). DR EMBL: M55335; SCMALQ(g). DR SwissProt: P10508; MA6R_YEAST. DR PIR: S03814; RGBYM3. XX RN [1] RA Ni B., Needleman R. B. RT Identification of the Upstream Activating Sequence RT of MAL and the Binding Sites for the MAL63 Activator RT of Saccharomyces cerevisiae RL Mol. Cell. Biol. 10:3797-3800 (1990). XX // AC T00481 XX ID T00481 XX DT 12.03.93 (created); ewi. XX FA MAPF1 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CP muscle XX RN [1] RA Santoro I. M., Yi T.-M., Walsh K. RT Identification of single-stranded-DNA-binding proteins RT that interact with muscle gene elements RL Mol. Cell. Biol. 11:1944-1953 (1991). XX // AC T00482 XX ID T00482 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA MAPF1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO 62K protein XX FF binds to the same sites as the myocyte-specific MAPF2 XX BS R00029; CHICK$AAC_01; Quality: 1; chick, Gallus gallus BS R00031; CHICK$AAC_03; Quality: 1; chick, Gallus gallus BS R00035; CHICK$AAC_07; Quality: 2; chick, Gallus gallus BS R03321; RAT$MLC_04; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Walsh K., Schimmel P. RT DNA-binding site for two skeletal actin promoter factors RT is important for expression in muscle cells RL Mol. Cell. Biol. 8:1800-1802 (1988). RN [2] RA Walsh K. RT Cross-Binding of Factors to Functionally Different RT Promoter Elements in c-fos and Skeletal Actin Genes RL Mol. Cell. Biol. 9:2191-2201 (1989). XX // AC T00483 XX ID T00483 XX DT 15.10.92 (created); ewi. XX FA MAPF2 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (L6 myoblasts) XX BS R00030; CHICK$AAC_02; Quality: 1; chick, Gallus gallus BS R00034; CHICK$AAC_06; Quality: 2; chick, Gallus gallus XX RN [1] RA Walsh K., Schimmel P. RT DNA-binding site for two skeletal actin promoter factors RT is important for expression in muscle cells RL Mol. Cell. Biol. 8:1800-1802 (1988). XX // AC T00484 XX ID T00484 XX DT 20.10.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA MASH-1 XX SY ASH-1; mammalian achaete-scute homolog 1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; 1.2.3.0.6. XX SZ 233 AA; 25.0 kDa (cDNA) XX SQ MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQAPQQQA SQ PQLSPVADGQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARR SQ NERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAA SQ FQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF XX SC SwissProt #P19359 XX FT 30 44 alanine-rich region (14/15) FT 45 62 glutamine-rich region (12/18) FT 119 127 basic region FT 128 168 helix-loop-helix domain XX CP nervous system: neuroepithelial and neural crest cells XX IN T00204; E12; human, Homo sapiens. IN T00675; E12; rat, Rattus norvegicus. IN T01652; HES-5; rat, Rattus norvegicus. IN T01787; E12; clawed frog, Xenopus laevis. IN T01789; SCBPgamma; rat, Rattus norvegicus. IN T01790; SCBPalpha; rat, Rattus norvegicus. IN T01791; SCBPbeta; rat, Rattus norvegicus. XX BS R00242; MOUSE$MCK_03; Quality: 6; mouse, Mus musculus XX DR EMBL: X53725; RNMASH1(r). DR SwissProt: P19359; ASH1_RAT. DR PIR: S11563; S11563. XX RN [1] RA Klein E. S., Simmons D. M., Swanson L. W., Rosenfeld M. G. RT Tissue-specific RNA splicing generates an ankyrin-like RT domain that affects the dimerization and DNA-binding RT properties of a bHLH protein RL Genes Dev. 7:55-71 (1993). RN [2] RA Johnson J. E., Birren S. J., Saito T., Anderson D. J. RT DNA binding and transcriptional regulatory activity RT of mammalian achaete-scute homologous (MASH) proteins RT revealed by interaction with a muscle-specific enhancer RL Proc. Natl. Acad. Sci. USA 89:3596-3600 (1992). RN [3] RA Lo L.-C., Johnson J. E., Wuenschell C. W., Saito T., Anderson D. J. RT Mammalian achaete-scute homolog 1 is transiently expressed RT by spatially restricted subsets of early neuroepithelial RT and neural crest cells RL Genes Dev. 5:1524-1537 (1991). XX // AC T00485 XX ID T00485 XX DT 20.10.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA MASH-2 XX SY ASH-2; mammalian achaete-scute homolog 2; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; 1.2.3.0.7. XX SZ 260 AA; 27.7 kDa XX SQ MESHFNWYGVPRLQKASDACPRESCSSALPEAREGANVHFPPHPVPREHFSCGAPKPVAG SQ APALNASLMDGGALPRLVPTSSGVAGACTARRRPPSPELLRCSRRRRSGATEASSSSAAV SQ ARRNERERNRVKLVNLGFQALRQHVPHGGANKKLSKVETLRSAVEYIRALQRLLAEHDAV SQ RAALSGGLLTPATRPSDVCTQPSASPASASLSCTSTSPDRLGCSEPASPRSAYSSEDSSC SQ EGETYPMGQMFDFSNWLGGY XX SC SwissProt #P19360 XX FT 122 130 basic region FT 131 171 helix-loop-helix domain XX IN T00204; E12; human, Homo sapiens. IN T00675; E12; rat, Rattus norvegicus. IN T01503; HEB; human, Homo sapiens. IN T01787; E12; clawed frog, Xenopus laevis. IN T01789; SCBPgamma; rat, Rattus norvegicus. IN T01790; SCBPalpha; rat, Rattus norvegicus. IN T01791; SCBPbeta; rat, Rattus norvegicus. XX BS R00242; MOUSE$MCK_03; Quality: 6; mouse, Mus musculus XX DR EMBL: X53724; RNMASH2(r). DR SwissProt: P19360; ASH2_RAT. DR PIR: S11562; S11562. XX RN [1] RA Klein E. S., Simmons D. M., Swanson L. W., Rosenfeld M. G. RT Tissue-specific RNA splicing generates an ankyrin-like RT domain that affects the dimerization and DNA-binding RT properties of a bHLH protein RL Genes Dev. 7:55-71 (1993). RN [2] RA Johnson J. E., Birren S. J., Saito T., Anderson D. J. RT DNA binding and transcriptional regulatory activity RT of mammalian achaete-scute homologous (MASH) proteins RT revealed by interaction with a muscle-specific enhancer RL Proc. Natl. Acad. Sci. USA 89:3596-3600 (1992). XX // AC T00486 XX ID T00486 XX DT 15.10.92 (created); ewi. DT 28.01.97 (updated); ewi. XX FA MATalpha1 XX SY alpha1; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0006; homeo; 3.1.1.0.4. XX SZ 175 AA; 20.4 kDa (gene) XX SQ MFTSKPAFKIKNKASKSYRNTAVSKKLKEKRLAEHVRPSCFNIIRPLKKDIQIPVPSSRF SQ LNKIQIHRIASGSQNTQFRQFNKTSIKSSKKYLNSFMAFRAYYSQFGSGVKQNVLSSLLA SQ EEWHADKMQHGIWDYFAQQYNFINPGFGFVEWLTNNYAEVRGDGYWEDVFVHLAL XX SC SwissProt #P01365 XX FT 129 191 homeo domain XX SF binds cooperatively with MCM1 to PQ elements of alpha-specific genes [10]; XX FF activator [10]; FF alpha1+MCM1 activate alpha-specific genes; FF responds to a-mating pheromone [10]; FF STE12 interaction is species-specific (no interaction with K. lactis STE12); FF transcription of the alpha 1 gene requires STE5 which FF itself is under a1/alpha2 repression [6]; XX IN T00500; MCM1; yeast, Saccharomyces cerevisiae. IN T00772; STE12; yeast, Saccharomyces cerevisiae. XX BS R01046; Y$MFAL1_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R01047; Y$MFAL1_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R01048; Y$MFAL2_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01364; Y$STE3_01; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: X59720; SCCHRIII(g). DR EMBL: V01313; SCMAT1A(g). DR EMBL: V01315; SCMAT2A(g). DR EMBL: L00060; SCMATAL(g). DR SwissProt: P01365; MAT1_YEAST. DR PIR: S19397; JFBYA1. XX RN [1] RA Bender A., Sprague Jr. G. F. RT MATalpha1 protein, a yeast transcription activator, RT binds synergistically with a second protein to a set RT of cell-type-specific genes RL Cell 50:681-691 (1987). RN [2] RA Yuan Y.-l., Stroke H. L., Fields S. RT Coupling of cell identity to signal response in yeast: RT interaction between the alpha1 and STE12 proteins RL Genes Dev. 7:1584-1597 (1993). RN [3] RA Primig M., Winkler H., Ammerer G. RT The DNA binding and oligomerization domain of MCM1 RT is sufficient for its interaction with other regulatory proteins RL EMBO J. 10:4209-4218 (1991). RN [4] RA Astell C. R., Ahlstrom-Jonasson L., Smith M. RT The sequence of the DNAs coding for the mating-type RT loci of saccharomyces cerevisiae RL Cell 27:15-23 (1981). RN [5] RA Nasmyth K. A., Tatchell K., Hall B. D., Astell C., Smith M. RT A position effect in the control of transcription at yeast mating type loci RL Nature 289:244-250 (1981). RN [6] RA Mukai Y., Harashima S., Oshima Y. RT Function of the Ste signal transduction pathway for RT mating pheromones sustains MATalpha1 transcription RT in Saccharomyces cerevisiae RL Mol. Cell. Biol. 13:2050-2060 (1993). RN [7] RA Jacquet M., Buhler J.-M., Iborra F., Francingues-Gaillard RA M.-C., Soustelle C. RT The MAT locus revisited within a 9.8 kb fragment of RT chromosome III containing BUD5 and two new open reading frames RL Yeast 7:881-888 (1991). RN [8] RA Tatchell K., Nasmyth K. A., Hall B. D., Astell C. R., Smith M. RT The sequence of the DNAs coding for the mating-type RT loci of Saccharomyces cerevisiae. RL Cell 27:25-35 (1981). RN [9] RA Passmore S., Elble R., Tye B.-K. RT A protein involved in minichromosome maintenance in RT yeast binds a transcriptional enhancer conserved in eukaryotes RL Genes Dev. 3:921-935 (1989). RN [10] RA Sengupta P., Cochran B. H. RT MATalpha1 can mediate gene activation by a-mating factor RL Genes Dev. 5:1924-1934 (1991). XX // AC T00487 XX ID T00487 XX DT 15.10.92 (created); ewi. DT 28.01.97 (updated); ewi. XX FA MATalpha2 XX SY YCL67C; YCR39C; YCR96C; alpha2; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0006; homeo; 3.1.1.0.5. XX SZ 210 AA; 24.3 kDa (gene), 24 kDa (SDS) XX SQ MNKIPIKDLLNPQITDEFKSSILDINKKLFSICCNLPKLPESVTTEEEVELRDILGFLSR SQ ANKNRKISDEEKKLLQTTSQLTTTITVLLKEMRSIENDRSNYQLTQKNKSADGLVFNVVT SQ QDMINKSTKPYRGHRFTKENVRILESWFAKNIENPYLDTKGLENLMKNTSLSRIQIKNWV SQ SNRRRKEKTITIAPELADLLSGEPLAKKKE XX SC SwissProt #P01367 XX FT 18 43 alpha2A dimerization motif for a1 FT 67 95 alpha2B dimerization motif for a1 through a coiled coil FT 92 128 interaction with MCM1 FT 129 191 homeo domain FT 138 150 alpha-helix 1 [22], [23]; FT 159 169 alpha-helix 2 [22], [23]; FT 173 189 alpha-helix 3 [22]; FT 1 10 essential for TUP1 interaction [14]; XX SF crystal structure (co-crystals with operator-DNA) SF [22], NMR [23]: despite only 27% sequence identity, SF the DNA-binding domain is similarly folded as that SF of Engrailed (T00253) [22], [23]; SF most conserved residues are important for repressor SF function in general, N182, K186, and K188 for haploid function only [16]; SF helix 3 forms base-specific and backbone contacts SF within the major groove [22]; SF nearly antiparallel orientation of helices 1 and 2, SF both perpendicularly packed across the hydrophobic surface of helix 3 [22]; SF extended conformation N-terminally adjacent to helix SF 1, fitting into minor groove [22]; SF different DNA-binding specificity of alpha2 homodimers SF and alpha2/a1 heterodimers [1], [19]; SF probably in a tandem arrangement with a1, alpha2 contacts SF a definite half-site of the dyad-symmetric site [3]; SF binds together with MCM1 to a-specific operators, SF contacting the flanking bases of the binding site SF [5], [17], [8], its exact spacing and orientation SF being governed by MCM1 [18]; SF some residues (132, 135, 173-188) involved in DNA-binding SF of homodimers or alpha2/MCM1 heterodimers are dispensable SF for DNA-binding of alpha2/a1 dimers [15]; SF in contrast, L196 is essential for repression with SF CM1, but not with a1 [15]; XX FF repressor of a-specific genes in alpha cells [4]; FF with a1: repressor of haploid-specific genes in diploid FF cells [9], [10], [1], [19]; FF alpha2 causes stable nucleosome binding adjacent to the operator [21], [24]; FF together with MCM1: specific recognition of STE6 promoter; FF cooperation with Ssn6-Tup1 required for alpha2/MCM1 FF action and, probably, also for that of alpha2/a1 [20]; XX IN T00487; MATalpha2; yeast, Saccharomyces cerevisiae. IN T00488; MATa1; yeast, Saccharomyces cerevisiae. IN T00500; MCM1; yeast, Saccharomyces cerevisiae. XX MX M00031; F$MATALPHA2_01 XX BS R03799; AS$HSO_01; Quality: 2 BS R00718; Y$HO_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R01019; Y$MATAL_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02482; Y$MATAL_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R01361; Y$STE2_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R01363; Y$STE2_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R01364; Y$STE3_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01365; Y$STE6_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01366; Y$STE6_02; Quality: 1; yeast, Saccharomyces cerevisiae XX DR EMBL: X59720; SCCHRIII(g). DR EMBL: V01313; SCMAT1A(g). DR EMBL: V01315; SCMAT2A(g). DR EMBL: L00060; SCMATAL(g). DR SwissProt: P01367; MAT2_YEAST. DR PIR: A01639; JEBY2. DR PIR: S19398; JFBYA2. DR PIR: S19512; S19512. DR PDB: 1apl; MAT ALPHA2 HOMEODOMAIN COMPLEXED WITH OPERATOR DNA YEAST. XX RN [1] RA Goutte C., Johnson A. D. RT a1 Protein Alters the DNA Binding Specificity of alpha2 Repressor RL Cell 52:875-882 (1988). RN [2] RA Ho C.-Y., Adamson J. G., Hodges R. S., Smith M. RT Heterodimerization of the yeast MATa1 and MATalpha2 RT proteins is mediated by two leucine zipper-like coiled-coil motifs RL EMBO J. 13:1403-1413 (1994). RN [3] RA Goutte C., Johnson A. D. RT Recognition of a DNA operator by a dimer composed RT of two different homeodomain proteins RL EMBO J. 13:1434-1442 (1994). RN [4] RA Johnson A. D., Herskowitz I. RT A repressor (MATalpha2 product) and its operator control RT expression of a set of cell type specific genes in yeast RL Cell 42:237-247 (1985). RN [5] RA Keleher C. A., Goutte C., Johnson A. D. RT The Yeast Cell-Type-Specific Repressor alpha2 Acts RT Cooperatively with a Non-Cell-Type-Specific Protein RL Cell 53:927-936 (1988). RN [6] RA Hall M. N., Johnson A. D. RT Homeo domain of the yeast repressor alpha2 is a sequence-specific RT DNA-binding domain but is not sufficient for repression RL Science 237:1007-1012 (1987). RN [7] RA Primig M., Winkler H., Ammerer G. RT The DNA binding and oligomerization domain of MCM1 RT is sufficient for its interaction with other regulatory proteins RL EMBO J. 10:4209-4218 (1991). RN [8] RA Keleher C. A., Passmore S., Johnson A. D. RT Yeast Repressor alpha2 Binds to Its Operator Cooperatively RT with Yeast Protein Mcm1 RL Mol. Cell. Biol. 9:5228-5230 (1989). RN [9] RA Strathern J., Hicks J., Herskowitz I. RT Control of cell type in yeast by the mating type locus RL J. Mol. Biol. 147:357-372 (1981). RN [10] RA Miller A. M., Mackay V. L., Nasmyth K. A. RT Identification and comparison of two sequence elements RT that confer cell-type specific transcription in yeast RL Nature 314:598-603 (1984). RN [11] RA Hochstrasser M., Ellison M. J., Chau V., Varshavsky A. RT The short-lived MATalpha2 transcriptional regulator is ubiquitinated in vivo RL Proc. Natl. Acad. Sci. USA 88:4606-4610 (1991). RN [12] RA Vershon A. K., Johnson A. D. RT A short, disordered protein region mediates interactions RT between the homeodomain of the yeast alpha2 protein and the MCM1 protein RL Cell 72:105-112 (1993). RN [13] RA Herschbach B. M., Johnson A. D. RT The yeast alpha2 protein can repress transcription RT by RNA polymerases I and II but not III RL Mol. Cell. Biol. 13:4029-4038 (1993). RN [14] RA Komachi K., Redd M. J., Johnson A. D. RT The WD repeats of Tup1 interact with the homeo domain protein alpha2 RL Genes Dev. 8:2857-2867 (1994). RN [15] RA Vershon A. K., Jin Y., Johnson A. D. RT A homeo domain protein lacking specific side chains RT of helix 3 can still bind DNA and direct transcriptional repression RL Genes Dev. 9:182-192 (1995). RN [16] RA Porter S. D., Smith A. RT Homeo-domain homology in yeast MATalpha2 is essential for repressor activity RL Nature 320:766-768 (1986). RN [17] RA Passmore S., Elble R., Tye B.-K. RT A protein involved in minichromosome maintenance in RT yeast binds a transcriptional enhancer conserved in eukaryotes RL Genes Dev. 3:921-935 (1989). RN [18] RA Smith D. L., Johnson A. D. RT A molecular mechanism for combinatorial control in RT yeast: MCM1 protein sets the spacing and orientation RT of the homeodomains of an alpha2 dimer RL Cell 68:133-142 (1992). RN [19] RA Dranginis A. M. RT Binding of yeast a1 and alpha2 as a heterodimer to RT the operator DNA of a haploid-specific gene RL Nature 347:682-685 (1990). RN [20] RA Keleher C. A., Redd M. J., Schultz J., Carlson M., Johnson A. D. RT Ssn6-Tup1 is a general repressor of transcription in yeast RL Cell 68:709-719 (1992). RN [21] RA Roth S. Y., Shimizu M., Johnson L., Grunstein M., Simpson R. T. RT Stable nucleosome positioning and complete repression RT by the yeast alpha2 repressor are disrupted by amino-terminal RT mutations in histone H4 RL Genes Dev. 6:411-425 (1992). RN [22] RA Wolberger C., Vershon A. K., Liu B., Johnson A. D., Pabo C. O. RT Crystal structure of a MATalpha2 homeodomain-operator RT complex suggests a general model for homeodomain-DNA interactions RL Cell 67:517-528 (1991). RN [23] RA Phillips C. L., Vershon A. K., Johnson A. D., Dahlquist F. W. RT Secondary structure of the homeo domain of yeast alpha2 RT repressor determined by NMR spectroscopy RL Genes Dev. 5:764-772 (1991). RN [24] RA Shimizu M., Roth S. Y., Szent-Gyorgyi C., Simpson R. T. RT Nucleosomes are positioned with base pair precision RT to the alpha2 operator in Saccharomyces cerevisiae RL EMBO J. 10:3033-3041 (1991). XX // AC T00488 XX ID T00488 XX DT 15.10.92 (created); ewi. DT 28.01.97 (updated); ewi. XX FA MATa1 XX SY YCR97W; a1; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0006; homeo; 3.1.1.18.3. XX SZ 126 AA; 14.8 kDa (gene), 16 kDa (SDS) XX FT 1 40 heterodimerization with alpha2 through a coiled coil FT 70 126 homeo domain FT 118 126 replaced by 118-130 in splice variant XX SF incomplete splice variant (130 AA, 15.3 kDa) [5], [8], [4]; SF requires heterodimerization with alpha2 for DNA-binding [6], [11]; SF no homodimerization [2]; XX FF a1/alpha2 heterodimer represses haploid-specific genes [1], [11]; XX IN T00487; MATalpha2; yeast, Saccharomyces cerevisiae. XX MX M00030; F$MATA1_01 XX BS R03799; AS$HSO_01; Quality: 2 BS R00718; Y$HO_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R01019; Y$MATAL_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02482; Y$MATAL_02; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: X59720; SCCHRIII(g). DR EMBL: V01312; SCMAT1(g). DR SwissProt: P09091; MTA0_YEAST. DR SwissProt: P01366; MTA1_YEAST. DR PIR: A01637; JEBY1. DR PIR: S19513; S19513. DR PIR: S22270; S22270. XX RN [1] RA Goutte C., Johnson A. D. RT a1 Protein Alters the DNA Binding Specificity of alpha2 Repressor RL Cell 52:875-882 (1988). RN [2] RA Ho C.-Y., Adamson J. G., Hodges R. S., Smith M. RT Heterodimerization of the yeast MATa1 and MATalpha2 RT proteins is mediated by two leucine zipper-like coiled-coil motifs RL EMBO J. 13:1403-1413 (1994). RN [3] RA Goutte C., Johnson A. D. RT Recognition of a DNA operator by a dimer composed RT of two different homeodomain proteins RL EMBO J. 13:1434-1442 (1994). RN [4] RA Astell C. R., Ahlstrom-Jonasson L., Smith M. RT The sequence of the DNAs coding for the mating-type RT loci of saccharomyces cerevisiae RL Cell 27:15-23 (1981). RN [5] RA Nasmyth K. A., Tatchell K., Hall B. D., Astell C., Smith M. RT A position effect in the control of transcription at yeast mating type loci RL Nature 289:244-250 (1981). RN [6] RA Miller A. M., Mackay V. L., Nasmyth K. A. RT Identification and comparison of two sequence elements RT that confer cell-type specific transcription in yeast RL Nature 314:598-603 (1984). RN [7] RA Sor F., Cheret G., Fabre F., Faye G., Fukuhara H. RT Yeast sequencing reports: Sequence of the HMR Region RT on Chromosome III of Saccharomyces cerevisiae RL Yeast 8:215-222 (1992). RN [8] RA Miller A. M. RT The yeast MATa1 gene contains two introns RL EMBO J. 3:1061-1065 (1984). RN [9] RA Shepherd J. C. W., McGinnis W., Carrasco A. E., Robertis RA E. M., Gehring W. J. RT Fly and frog homeo domains show homologies with yeast RT mating typre regulatory proteins RL Nature 310:70-71 (1984). RN [10] RA Ko H.-S., Fast P., McBride W., Staudt L. M. RT A Human Protein Specific for the Immunoglobulin Octamer RT DNA Motif Contains a Functional Homeobox Domain RL Cell 55:135-144 (1988). RN [11] RA Dranginis A. M. RT Binding of yeast a1 and alpha2 as a heterodimer to RT the operator DNA of a haploid-specific gene RL Nature 347:682-685 (1990). XX // AC T00489 XX ID T00489 XX DT 21.10.92 (created); ewi. DT 20.05.97 (updated); ewi. XX FA Max1 XX SY Max; Myn (mouse); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0012; bHLH-ZIP; 1.3.2.2.1.2. XX SZ 151 AA; 17.2 kDa (cDNA), 20 kDa, 22 kDa (SDS) XX SQ MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATE SQ YIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGS SQ TISAFDGGSDSSSESEPEEPQSRKKLRMEAS XX SC edited SwissProt #P25912 XX FT 2 2 Ser-phosphorylation by CKII [11]; FT 3 14 acidic region FT 11 11 Ser-phosphorylation by CKII [11]; FT 15 26 basic region FT 27 66 helix-loop-helix domain FT 65 93 leucine zipper (MHL3) FT 90 151 replaced in delta Max by GESES [3]; FT 140 147 nuclear localization signal (NLS) [19]; XX SF Max homodimers and Myc/Max heterodimers exhibit different SF preferences for the trinucleotides flanking the core sequence (CACGTG) [1]; SF Max1 and Max2 also differ slightly in their DNA-binding SF specificity [1], [15]; SF heterodimers with either c-Myc or Mad exert higher SF DNA-binding affinity than Max homodimers unless the SF inhibiting CKII phosphorylation site is replaced by SF alanine [12], [20], [16]; SF heterodimerization requires the leucine zipper, but SF not homodimerization [19], [8]; SF DNA-binding by Max or Myc/Max induces bending towards SF the minor groove by 74-82 deg, but possibly in opposite SF orientiations [2], [7]; XX FF enhances c-Myc DNA-binding; FF in high concentrations: homodimers suppress c-Myc FF activities by competition [19], [3], [5]; FF after CKII phosphorylation, increases in on- and off-rates FF of DNA-binding of homo- and heterodimers have been found [11]; FF preferentially complexed with Mad instead of c-Myc FF upon myeloid differentiation [14]; XX IN T00140; c-Myc; human, Homo sapiens. IN T00141; c-Myc; chick, Gallus gallus. IN T00142; c-Myc; rat, Rattus norvegicus. IN T00143; c-Myc; mouse, Mus musculus. IN T00489; Max1; human, Homo sapiens. IN T01445; N-Myc; mouse, Mus musculus. IN T01564; Mxi1; human, Homo sapiens. IN T01565; Mad; human, Homo sapiens. IN T01566; deltaMax; human, Homo sapiens. XX MX M00118; V$MYCMAX_01 MX M00119; V$MAX_01 MX M00123; V$MYCMAX_02 XX BS R02092; AS$MYC_01; Quality: 2 BS R02094; AS$MYC_02; Quality: 1 BS R04415; HS$ODC_01; Quality: 4; human, Homo sapiens BS R04414; RAT$PTHYA_01; Quality: 1; rat, Rattus norvegicus XX DR EMBL: M64240; HSMAX(r). DR SwissProt: P25912; MAX_HUMAN. XX RN [1] RA Solomon D. L. C., Amati B., Land H. RT Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers RL Nucleic Acids Res. 21:5372-5376 (1993). RN [2] RA Fisher D. E., Parent L. A., Sharp P. A. RT Myc/Max and other helix-loop-helix/leucine zipper RT proteins bend DNA toward the minor groove RL Proc. Natl. Acad. Sci. USA 89:11779-11783 (1992). RN [3] RA Maekelae T. P., Koskinen P. J., Vaestrik I., Alitalo K. RT Alternative forms of Max as enhancers or suppressors RT of Myc-Ras cotransformation RL Science 256:373-377 (1992). RN [4] RA Blackwood E. M., Luescher B., Eisenman R. N. RT Myc and Max associate in vivo RL Genes Dev. 6:71-80 (1992). RN [5] RA Amati B., Brooks M. W., Levy N., Littlewood T. D., Evan G. I., Land H. RT Oncogenic activity of the c-Myc protein requires dimerization with Max RL Cell 72:233-245 (1993). RN [6] RA Min S., Taparowsky E. J. RT v-Myc, but not Max, possesses domains that function RT in both transcription activation and cellular transformation RL Oncogene 7:1531-1540 (1992). RN [7] RA Wechsler D. S., Dang C. V. RT Opposite directions of DNA bending by c-Myc and Max RL Proc. Natl. Acad. Sci. USA 89:7635-7639 (1992). RN [8] RA Reddy C. D., Dasgupta P., Saikumar P., Dudek H., Rauscher RA III F. J., Reddy E. P. RT Mutational analysis of Max: role of basic, helix-loop-helix/leucine RT zipper domains in DNA binding, dimerization and regulation RT of Myc-mediated transcriptional activation RL Oncogene 7:2085-2092 (1992). RN [9] RA Wagner A. J., Le Beau M. M., Diaz M. O., Hay N. RT Expression, regulation, and chromosomal localization of the Max gene RL Proc. Natl. Acad. Sci. USA 89:3111-3115 (1992). RN [10] RA Fisher F., Crouch D. H., Jayaraman P. S., Clark W., RA Gillespie D. A. F., Goding C. R. RT Transcription activation by Myc and Max: flanking RT sequences target activation to a subset of CACGTG motifs in vivo RL EMBO J. 12:5075-5082 (1993). RN [11] RA Bousset K., Henriksson M., Luescher-Firzlaff J. M., RA Litchfield D. W., Luescher B. RT Identification of casein kinase II phosphorylation RT sites in Max: effects on DNA-binding kinetics of Max RT homo- and Myc/Max heterodimers RL Oncogene 8:3211-3220 (1993). RN [12] RA Ayer D. E., Kretzner L., Eisenman R. N. RT Mad: a heterodimeric partner for Max that antagonizes RT Myc transcriptional activity RL Cell 72:211-222 (1993). RN [13] RA Zervos A. S., Gyuris J., Brent R. RT Mxi1, a protein that specifically interacts with Max RT to bind Myc-Max recognition sites RL Cell 72:223-232 (1993). RN [14] RA Ayer D. E., Eisenman R. N. RT A switch from Myc:Max to Mad:Max heterocomplexes accompanies RT monocyte/macrophage differentiation RL Genes Dev. 7:2110-2119 (1993). RN [15] RA Prochownik E. V., Antwerp M. E. RT Differential patterns of DNA binding by myc and max proteins RL Proc. Natl. Acad. Sci. USA 90:960-964 (1993). RN [16] RA Kohlhuber F., Hermeking H., Graessmann A., Eick D. RT Induction of apoptosis by the c-Myc helix-loop-helix/leucine RT zipper domain in mouse 3T3-L1 fibroblasts RL J. Biol. Chem. 270:28797-28805 (1995). RN [17] RA Blackwood E. M., Eisenman R. N. RT Max: a helix-loop-helix zipper protein that forms RT a sequence-specific DNA-binding complex with Myc RL Science 251:1211-1217 (1991). RN [18] RA Wenzel A., Cziepluch C., Hamann U., Schuermann J., Schwab M. RT The N-Myc oncoprotein is associated in vivo with the RT phosphoprotein Max(p20/22) in human neuroblastoma cells RL EMBO J. 10:3703-3712 (1991). RN [19] RA Kato G. J., Lee W. M. F., Chen L., Dang C. V. RT Max: functional domains and interaction with c-Myc RL Genes Dev. 6:81-92 (1992). RN [20] RA Berberich S. J., Cole M. D. RT Casein kinase II inhibits the DNA-binding activity RT of Max homodimers but not Myc/Max heterodimers RL Genes Dev. 6:166-176 (1992). XX // AC T00490 XX ID T00490 XX DT 10.11.92 (created); ewi. DT 02.09.96 (updated); ewi. XX FA MAZ XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; . XX SZ 477 AA; 48.6 kDa (cDNA) XX SQ MFPVFPCTLLAPPFPVLGLDSRGVGGLMNSFPPPQGHAQNPLQVGAELQSRFFASQGCAQ SQ SPFQAAPAPPPTPQAPAAEPLQVDLLPVLAAAQESAAAAAAAAAAAAAVAAAPPAPAAAS SQ TVDTAALKQPPAPPPPPPPVSAPAAEAAPPASAATIAAAAATAVVAPTSTVAVAPVASAL SQ EKKTKSKGPYICALCAKEFKNGYNLRRHEAIHTGAKAGRVPSGAMKMPTMVPLSLLSVPQ SQ LSGAGGGGGEAGAGGGAAAVAAGGVVTTTASGKRIRKNHACEMCGKAFRDVYHLNRHKLS SQ HSDEKPYQCPVCQQRFKRKDRMSYHVRSHDGAVHKPYNCSHCGKSFSRPDHLNSHVRQVH SQ STERPFKCEKCEAAFATKDRLRAHTVRHEEKVPCHVCGKMLSSAYISDHMKVHSQGPHHV SQ CELCNKGTGEVCPMAAAAAAAAAAAAAAVAAPPTAVGSLSGAEGVPVSSQPLPSQPW XX SC translated from EMBL #M94046 XX FT 65 179 proline-/alanine-rich region (76/115) XX SF 6 zinc finger motifs SF proline-/alanine-rich region XX CP ubiquitous XX FF may be involved in transcriptional initiation and FF termination at the c-myc P2 promoter XX BS R02306; MOUSE$CMYC_04; Quality: 6; mouse, Mus musculus XX DR EMBL: M94046; HSMAZ(r). XX RN [1] RA Bossone St. A., Asselin C., Patel A. J., Marcu K. B. RT MAZ, a zinc finger protein, binds to c-MYC and C2 RT gene sequences regulating transcriptional initiation and termination RL Proc. Natl. Acad. Sci. USA 89:7452-7456 (1992). XX // AC T00491 XX ID T00491 XX DT 26.01.93 (created); hse. DT 25.03.94 (updated); hwi. XX FA MBF-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP myocytes XX FF regulated in a reciprocal manner to MEF-2 XX BS R02197; MBF1$CONS; Quality: 6 BS R00243; MOUSE$MCK_04; Quality: 6; mouse, Mus musculus XX RN [1] RA Gossett L. A., Kelvin D. J., Sternberg E. A., Olson E. N. RT A new myocyte-specific enhancer-binding factor that RT recognizes a conserved element associated with multiple RT muscle-specific genes RL Mol. Cell. Biol. 9:5022-5033 (1989). XX // AC T00492 XX ID T00492 XX DT 15.10.92 (created); ewi. XX FA MBF1 XX SY MBF-1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00194; EBV$BRLF1_01; Quality: 6; EBV, Epstein-Barr virus BS R00197; EBV$BZLF1_01; Quality: 6; EBV, Epstein-Barr virus BS R00198; EBV$BZLF1_02; Quality: 6; EBV, Epstein-Barr virus BS R00199; EBV$BZLF1_03; Quality: 6; EBV, Epstein-Barr virus BS R01911; HCMV$IEMP_02; Quality: 6; hCMV, human cytomegalovirus XX RN [1] RA Shelbourn S. L., Kothari S. K., Sissons J. G. P., Sinclair J. H. RT Repression of human cytomegalovirus gene expression RT associated with a novel immediate early regulatory region binding factor RL Nucleic Acids Res. 17:9165ff (1989). XX // AC T00493 XX ID T00493 XX DT 15.10.92 (created); ewi. XX FA MBF2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01912; HCMV$IEMP_03; Quality: 6; hCMV, human cytomegalovirus XX RN [1] RA Shelbourn S. L., Kothari S. K., Sissons J. G. P., Sinclair J. H. RT Repression of human cytomegalovirus gene expression RT associated with a novel immediate early regulatory region binding factor RL Nucleic Acids Res. 17:9165ff (1989). XX // AC T00494 XX ID T00494 XX DT 15.10.92 (created); ewi. XX FA MBF3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01912; HCMV$IEMP_03; Quality: 6; hCMV, human cytomegalovirus XX RN [1] RA Shelbourn S. L., Kothari S. K., Sissons J. G. P., Sinclair J. H. RT Repression of human cytomegalovirus gene expression RT associated with a novel immediate early regulatory region binding factor RL Nucleic Acids Res. 17:9165ff (1989). XX // AC T00495 XX ID T00495 XX DT 15.10.92 (created); ewi. DT 16.03.94 (updated); hwi; ewi. XX FA MBF-I XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 74 kDa (SDS) XX FF involved in metallothionein regulation XX BS R02198; MBFI$CONS; Quality: 6 BS R01816; TROUT$MT1_01; Quality: 6; rainbow trout, Salmo gairdneri XX DR EMBL: M30830; MMMBFI(g). XX RN [1] RA Imbert J., Zafarullah M., Culotta V. C., Gedamu L., Hamer D. RT Transcription Factor MBF-I Interacts with Metal Regulatory RT Elements of Higher Eukaryotic Metallothionein Genes RL Mol. Cell. Biol. 9:5315-5323 (1989). XX // AC T00496 XX ID T00496 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA MBP-2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; 2.3.4.0.3. XX SF at least 2 zinc finger motifs SF acidic region XX CP B cells XX BS R01057; MOUSE$M1H2KB_05; Quality: 6; mouse, Mus musculus XX DR EMBL: M61744; HSMBP2(r). XX RN [1] RA Rustgi A. K., Van't Veer L., Bernards R. RT Two genes encode factors with NF-kappaB- and H2TF1-like RT DNA-binding properties RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990). XX // AC T00497 XX ID T00497 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA MBP-1 (1) XX SY HIV-EP1; MHC-binding protein 1; PRDII-BF1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; 2.3.4.0.1. XX SZ 2717 AA; 297 kDa (cDNA) XX SQ MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKEILQAGVKGTSESLKGVKRKKIVAENHLK SQ KIPKSPLRNPLQAKHKQNTEESSFAVLHSASESHKKQNYIPVKNGKQFTKQNGETPGIIA SQ EASKSEESVSPKKPLFLQQPSELRRWRSEGADPAKFSDLDEQCDSSSLSSKTRTDNSECI SQ SSHCGTTSPSYTNTAFDVLLKAMEPELSTLSQKGSPCAIKTEKLRPNKTARSPPKLKNSS SQ MDAPNQTSQELVAESQSSCTSYTVHMSAAQKNEQGAMQSASHLYHQHEHFVPKSNQHNQQ SQ LPGCSGFTGSLTNLQNQENAKLEQVYNIAVTSSVGLTSPSSRSQVTPQNQQMDSASPLSI SQ SPANSTQSPPMPIYNSTHVASVVNQSVEQMCNLLLKDQKPKKQGKYICEYCNRACAKPSV SQ LLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKLGLVLQPDAGGLFLSHESP SQ KALSIHSDVEDSGESEEEGATDERQHDLGAMELQNVHIIKRMSNAETLLKSSFTPSSPEN SQ VIGDFLLQDRSAESQAVTELPKVVVHHVTVSPLRTDSPKAMDPKPELSSAQKQKDLQVTN SQ VQPLSANMSQGGVSRLETNENSHQKGDMNPLEGKQDSHVGTVHAQLQRQQATDYSQEQQG SQ KLLSPRSLGSTDSGYFSRSESADQTVSPPTPFARRFPAQNKTLEGVTDPLQLLSPRQHPL SQ LCHREKALLLPGQMRPPLATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSID SQ SPKSYIFKDSFQFDLKPVGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNS SQ MPTTGYSAVPANIIPPPHPLRGSQSFDDKIGAFYDDVFVSGPNAPVPQSGHPRTLVRQAA SQ IEDSSANESHVLGTGQSLDESHQGCHAAGEAMSVRSKALAQGPHIEKKKSHQGRGTMFEC SQ ETCRNRYRKLENFENHKKFYCSELHGPKTKVAMREPEHSPVPGGLQPQILHYRVAGSSGI SQ WEQTPQIRKRRKMKSVGDDEELQQNESGTSPKSSEGLQFQNALGCNPSLPKHSVTIRSDQ SQ QHKNIQLQNSHIHLVARGPEQTMDPKLSTIMEQQISSAAQDKIELQRHGTGISVIQHTNS SQ LSRPNSFDKPEPFERASPVSFQELNRTGNSGSLKVIGISQEESHPSRDGSHPHQLALSDA SQ LRGELQESSRKSPSERHVLGQPSRLIRQHNIQVPEILVTEEPDRDLEAQCHDQEKSEKFS SQ WPQRSETLSKLPTEKLPPKKKRLRLAEIEHSSTESSFDSTLSRSLSRESSLSHTSSFSAS SQ LDIEDVSKTEASPKIDFLNKAEFLMIPAGLNTLNVPGCHREMRRTASEQINCTQTSMEVS SQ DLRSKSFDCGSITPPQTTPLTELQPPSSPSRVGVTGHVPLLERRRGPLVRQISLGIAPDS SQ HLSPVHPTSFQNTALPSVNAVPYQGPQLTSTSLAEFSANTLHSQTQVKDLQAETSNSSST SQ NVFPVQQLCDINLLNQIHAPPSHQSTQLSLQVSTQGSKPDKNSVLSGSSKSEDCFAPKYQ SQ LHCQVFTSGPSCSSNPVHSLPNQVISDPVGTDHCVTSATLPTKLIDSMSNSHPLLPPELR SQ PLGSQVQKVPSSFMLPIRLQSSVPAYCFATLTSLPQILVTQDLPNQPICQTNHSVVPISE SQ EQNSVPTLQKGHQNALPNPEKEFLCENVFSEMSQNSSLSESLPITQKISVGRLSPQQESS SQ ASSKRMLSPANSLDIAMEKHQKRAKDENGAVCATDVRPLEALSSRVNEASKQKKPILVRQ SQ VCTTEPLDGVMLEKDVFSQPEISNEAVNLTNVLPADNSSTGCSKFVVIEPISELQEFENI SQ KSSTSLTLTVRSSPAPSENTHLSPLKCTDNNQERKSPGVKNQGDKVNIQEQSQRPVTSLS SQ LFNIKDTQQLAFPSLKTTTNFTWCYLLRQKSLHLPQKDQKTSAYTDWTVSASNPNPLGLP SQ TKVALALLNSKQNTGKSLYCQAITTHSKSDLLVYSSKWKSSLSKRALGNQKSTVVEFSNK SQ DASEINSEQDKENSLIKSEPRRIKIFDGGYKSNEEYVYIRGRGRGKYICEECGIRCKKPS SQ MLKKHIRTHTDVRPYHCTYCNFSFKTKGNLTKHMKSKAHSKKCVDLGISVGLIDEQDTEE SQ SDEKQRFSYERSGYDLEESDGPDEDDNENEDDDEDSQAESVLSATPSVTASPQHLPSRSS SQ LQDPVSTDEDVRITDCFSGVHTDPMDVLPRALLTRMTVLSTAQSDYNRKTLSPGKARQRA SQ ARDENDTIPSVDTSRSPCHQMSVDYPESEEILRSSMAGKAVAITQSPSSVRLPPAAAEHS SQ PQTAAGMPSVASPHPDPQEQKQQITLQPTPGLPSPHTHLFSHLPLHSQQQSRTPYNMVPV SQ GGIHVVPAGLTYSTFVPLQAGPVQLTIPAVSVVHRTLGTHRNTVTEVSGTTNPAGVAELS SQ SVVPCIPIGQIRVPGLQNLSTPGLQSLPSLSMETVNIVGLANTNMAPQVHPPGLALNAVG SQ LQVLTANPSSQSSPAPQAHIPGLQILNIALPTLIPSVSQVAVDAQGAPEMPASQSKACET SQ QPKQTSVASANQVSRTESPQGLPTVQRENAKKVLNPPAPAGDHARLDGLSKMDTEKAASA SQ NHVKPKPELTSIQGQPASTSQPLLKAHSEVFTKPSGQQTLSPDRQVPRPTGLPRRQPTVH SQ FSDVSSDDDEDRLVIAT XX SC SwissProt #P15822 XX SF 2+1+2 zinc finger motifs SF acidic region SF NMR of the second zinc finger XX CP B cells XX BS R00699; HIV1$HIV1_06; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R01745; HIV1$HIV1_15; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R01746; HIV1$HIV1_16; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R00928; HS$IFNB_13; Quality: 6; human, Homo sapiens BS R02199; MBP1$CONS; Quality: 6 BS R01059; MOUSE$M1H2KB_07; Quality: 6; mouse, Mus musculus BS R01060; MOUSE$M1H2KB_08; Quality: 6; mouse, Mus musculus XX DR EMBL: X51435; HSZFPBF1(r). DR SwissProt: P15822; ZEP1_HUMAN. DR PIR: A34203; A34203. XX RN [1] RA Fan C.-M., Maniatis T. RT A DNA-binding protein containing two widely separated RT zinc finger motifs that recognize the same DNA sequence RL Genes Dev. 4:29-42 (1990). RN [2] RA Maekawa T., Sakura H., Sudo T., Ishii S. RT Putative metal finger structure of the human immunodeficiency RT virus type 1 enhancer binding protein HIV-EP1 RL J. Biol. Chem. 264:14591-14593 (1989). RN [3] RA Rustgi A. K., Van't Veer L., Bernards R. RT Two genes encode factors with NF-kappaB- and H2TF1-like RT DNA-binding properties RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990). RN [4] RA Baldwin Jr. A. S., LeClair K. P., Singh H., Sharp P. A. RT A large protein containing zinc finger domains binds RT to related sequence elements in the enhancers of the RT class I major histocompatibility complex and kappa immunoglobulin genes RL Mol. Cell. Biol. 10:1406-1414 (1990). RN [5] RA Maekawa T., Sakura H., Sudo T., Ishii S. RT Putative metal finger structure of the human immunodeficiency RT virus type 1 enhancer binding protein HIV-EP1 RL J. Biol. Chem. 264:14591-14593 (1989). RN [6] RA Omichinski J. G., Clore G. M., Appella E., Sakaguchi K., Gronenborn A. M. RT High-resolution three-dimensional structure of a single RT zinc finger from a human enhancer binding protein in solution RL Biochemistry 29:9324-9334 (1990). XX // AC T00498 XX ID T00498 XX DT 12.03.93 (created); ewi. DT 22.08.96 (updated); ewi. XX FA MBP-1 (2) XX SY myc-promoter binding protein; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 335 AA; 37.1 kDa (cDNA), 37 kDa (SDS) XX SQ MEQKINLSLVRTPFWGCPLPSAKLVPLRRGSPVPPHRVLGWQLRSHPASPGVQVSSSMAV SQ LMLATSWPCRVCPPSRCSKLREAMPHWSRGLPQPEECHQGEIWERCHQCGDLRGFAPNIL SQ ENKEGLELLKTAIGKPGLHCKGGHGMDVAASEFFRSGNYDLDFKSPDDPSRYISPDQLAD SQ LYKSFIKDYPVVSIEDPFDQDDWGASEVHSQCRNPGSGGMTHSDQPKEDRQGVNEKSCNC SQ LLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGADQDWCPL SQ PITRLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK XX SC SwissProt #P22712 XX SF proline-rich region XX FF repressor (c-myc) XX BS R03048; HS$CMYC_11; Quality: 6; human, Homo sapiens XX DR EMBL: M55914; HSCMYCQ(r). DR SwissProt: P22712; MBP1_HUMAN. DR PIR: A39579; A39579. XX RN [1] RA Ray R., Miller D. M. RT Cloning and characterization of a human c-myc promoter-binding protein RL Mol. Cell. Biol. 11:2154-2161 (1991). XX // AC T00499 XX ID T00499 XX DT 26.01.93 (created); hse. XX FA MCBF XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CP embryonic muscle tissue XX FF regulates expression of the cTNT and alpha-actin gene promoters XX BS R02075; CHICK$AAC_08; Quality: 1; chick, Gallus gallus BS R02073; CHICK$CTNT_02; Quality: 1; chick, Gallus gallus BS R02074; CHICK$CTNT_03; Quality: 1; chick, Gallus gallus BS R02200; MCBF$CONS; Quality: 6 XX RN [1] RA Mar J. H., Ordahl Ch. P. RT M-CAT Binding Factor, a Novel trans-Acting Factor RT Governing Muscle-Specific Transcription RL Mol. Cell. Biol. 10:4271-4283 (1990). XX // AC T00500 XX ID T00500 XX DT 15.10.92 (created); ewi. DT 09.05.96 (updated); ewi. XX FA MCM1 XX SY GRM; PRTF; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0014; MADS; 4.3.1.3.1. XX SZ 286 AA; 32.8 kDa (gene) XX SQ MSDIEEGTPTNNGQQKERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLL SQ LVVSETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDEEEDEEEDGDDDDDDDDDGND SQ MQRQQPQQQQPQQQQQVLNAHANSLGHLNQDQVPAGALKQEVKSQLLGGANPNQNSMIQQ SQ QQHHTQNSQPQQQQQQQPQQQMSQQQMSQHPRPQQGIPHPQQSQPQQQQQQQQQLQQQQQ SQ QQQQQPLTGIHQPHQQAFANAASPYLNAEQNAAYQQYFQEPQQGQY XX SC SwissProt #P11746 XX FT 18 72 MADS box FT 98 120 acidic region (21/23), required for FT alpha-specific gene activation [11]; FT 121 285 glutamine-rich region (71/165), trans-activation FT domain [11]; FT 1 98 sufficient for interaction with alpha1, alpha2 FT 71 98 STE12-binding XX SF dimeric binding to sequence elements with dyad symmetry [19]; SF DNA-binding modulated by MATalpha1 and MATalpha2 [6], [19], [11]; SF MCM1 sets spacing and orientation of the homeo domains SF of two alpha2 molecules on the DNA such that MCM1 SF contacts the central 11bp, alpha2 the 10 flanking SF base pairs at both sides [6], [19], [4]; SF the DNA-binding MADS box is sufficient for repressing SF a-specific genes and for replication initiation [8], [11]; SF by direct interaction through AA 73, 75, 77 abd 78, SF MCM1 forms a ternary complex with STE12 that represses SF the a-specific STE2 gene [3]; SF Glu-17 is important to define DNA sequence specificity SF compared with vertebrate MEF-2 and SRF [15]; XX FF activator by its own or, for alpha-specific genes, FF in cooperation with MATalpha1 [1], [16], [19], [11]; FF repressor of a-specific genes in cooperation with FF MATalpha2 [5], [16], [19], [11]; FF activator of replication of DNA [11]; FF presumably regulates genes involved in cell cycle FF control, in synthesis of cell wall/ membrane structures, FF cell metabolism, and an heat-shocl-inducible secreted glycoprotein [14]; XX IN T00486; MATalpha1; yeast, Saccharomyces cerevisiae. IN T00487; MATalpha2; yeast, Saccharomyces cerevisiae. IN T00500; MCM1; yeast, Saccharomyces cerevisiae. IN T00772; STE12; yeast, Saccharomyces cerevisiae. IN T00801; TCF; human, Homo sapiens. IN T01099; alpha-1; maize, Zea mays. IN T01289; STE12; yeast, Kluyveromyces lactis. IN T01399; TCF; mouse, Mus musculus. XX MX M00125; F$MCM1_01 XX BS R03821; AS$MCM1_01; Quality: 2 BS R03822; AS$MCM1_02; Quality: 2 BS R03608; AS$SRF_02; Quality: 6 BS R00466; HS$CFOS_09; Quality: 2; human, Homo sapiens BS R01889; HS$CFOS_16; Quality: 1; human, Homo sapiens BS R00474; MOUSE$CFOS_03; Quality: 6; mouse, Mus musculus BS R03057; Y$ARG56_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01902; Y$CDC28_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R01045; Y$MFAL1_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R01046; Y$MFAL1_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R01047; Y$MFAL1_03; Quality: 1; yeast, Saccharomyces cerevisiae BS R01901; Y$MFAL1_04; Quality: 1; yeast, Saccharomyces cerevisiae BS R01048; Y$MFAL2_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R01363; Y$STE2_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R01364; Y$STE3_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01891; Y$STE3_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R01900; Y$STE3_04; Quality: 3; yeast, Saccharomyces cerevisiae BS R01365; Y$STE6_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01366; Y$STE6_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R01892; Y$STE6_03; Quality: 1; yeast, Saccharomyces cerevisiae BS R01476; Y$TY1_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01477; Y$TY1_02; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: M17511; SCFUN80(g). DR EMBL: X14187; SCMCM1(g). DR SwissProt: P11746; MCM1_YEAST. DR PIR: A34599; A34599. XX RN [1] RA Bender A., Sprague Jr. G. F. RT MATalpha1 protein, a yeast transcription activator, RT binds synergistically with a second protein to a set RT of cell-type-specific genes RL Cell 50:681-691 (1987). RN [2] RA Ammerer G. RT Identification, purification and cloning of a polypeptide RT (PRTF/GRM) that binds to mating-specific promoter elements in yeast RL Genes Dev. 4:299-312 (1990). RN [3] RA Mueller C. G. F., Nordheim A. RT A protein domain conserved between yeast MCM1 and RT human SRF directs ternary complex formation RL EMBO J. 10:4219-4229 (1991). RN [4] RA Smith D. L., Johnson A. D. RT Operator-constitutive mutations in a DNA sequence RT recognized by a yeast homeodomain RL EMBO J. 13:2378-2387 (1994). RN [5] RA Johnson A. D., Herskowitz I. RT A repressor (MATalpha2 product) and its operator control RT expression of a set of cell type specific genes in yeast RL Cell 42:237-247 (1985). RN [6] RA Keleher C. A., Goutte C., Johnson A. D. RT The Yeast Cell-Type-Specific Repressor alpha2 Acts RT Cooperatively with a Non-Cell-Type-Specific Protein RL Cell 53:927-936 (1988). RN [7] RA Company M., Errede B. RT A Ty1 Cell-Type-Specific Regulatory Sequence Is a RT Recognition Element for a Constitutive Binding Factor RL Mol. Cell. Biol. 8:5299-5309 (1988). RN [8] RA Primig M., Winkler H., Ammerer G. RT The DNA binding and oligomerization domain of MCM1 RT is sufficient for its interaction with other regulatory proteins RL EMBO J. 10:4209-4218 (1991). RN [9] RA Dubois E., Bercy J., Descamps F., Messenguy F. RT Characterization of two new genes essential for vegetative RT growth in Saccharomyces cerevisiae: Nucleotide sequence RT determination and chromosome mapping RL Gene 55:265-275 (1987). RN [10] RA Passmore S., Maine G. T., Elble R., Christ C., Tye B. K. RT Saccharomyces cerevisiae Protein Involved in Plasmid RT Maintenance in Necessary for Mating of MAT-alpha Cells RL J. Mol. Biol. 204:593-606 (1988). RN [11] RA Christ C., Tye B.-K. RT Functional domains of the yeast transcription/replication factor MCM1 RL Genes Dev. 5:751-763 (1991). RN [12] RA Passmore S., Maine G. T., Elble R., Christ C., Tye B. K. RT Saccharomyces cerevisiae protein involved in plasmid RT maintenance is necessary for mating of MAT alpha cells RL J. Mol. Biol. 204:593-606 (1988). RN [13] RA Dubois E., Bercy J., Descamps F., Messenguy F. RT a RL Gene 55:265-275 (1987). RN [14] RA Kuo M.-H., Grayhack E. RT A library of yeast genomic MCM1 binding sites contains RT gene involved in cell cycle control, cell wall and RT membrane structure, and metabolism RL Mol. Cell. Biol. 14:348-359 (1994). RN [15] RA Nurrish S. J., Treisman R. RT DNA binding specificity determinants in MADS-box transcription factors RL Mol. Cell. Biol. 15:4076-4085 (1995). RN [16] RA Keleher C. A., Passmore S., Johnson A. D. RT Yeast Repressor alpha2 Binds to Its Operator Cooperatively RT with Yeast Protein Mcm1 RL Mol. Cell. Biol. 9:5228-5230 (1989). RN [17] RA Hayes T. E., Sengupta P., Cochran B. H. RT The human c-fos serum response factor and the yeast RT factors GRM/PRTF have related DNA-binding specificities RL Genes Dev. 2:1713-1722 (1988). RN [18] RA Jarvis E. E., Clarc K. L., Sprague G. F., jr. - RT The yeast transcription activator PRTF, a homolog RT of the mammalian serum response factor, is encoded by the MCM1 gene RL Genes Dev. 3:936-945 (1989). RN [19] RA Passmore S., Elble R., Tye B.-K. RT A protein involved in minichromosome maintenance in RT yeast binds a transcriptional enhancer conserved in eukaryotes RL Genes Dev. 3:921-935 (1989). RN [20] RA Dubois E., Messenguy F. RT In vitro studies of the binding of the ARGR proteins to the ARG5,6 promoter RL Mol. Cell. Biol. 11:2162-2168 (1991). RN [21] RA Hipskind R. A., Rao V. N., Mueller C. G. F., Reddy E. S. P., Nordheim A. RT Ets-related protein Elk-1 is homologous to the c-fos RT regulatory factor p62TCF RL Nature 354:531-534 (1991). RN [22] RA Smith D. L., Johnson A. D. RT A molecular mechanism for combinatorial control in RT yeast: MCM1 protein sets the spacing and orientation RT of the homeodomains of an alpha2 dimer RL Cell 68:133-142 (1992). XX // AC T00501 XX ID T00501 XX DT 15.10.92 (created); ewi. DT 08.04.94 (updated); hwi. XX FA MCM1+MATalpha1 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX BS R03822; AS$MCM1_02; Quality: 2 BS R01364; Y$STE3_01; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: M17511; SCFUN80(g). DR EMBL: V01315; SCMAT2A(g). DR EMBL: X14187; SCMCM1(g). DR SwissProt: P01365; MAT1_YEAST. DR SwissProt: P11746; MCM1_YEAST. DR PIR: A34599; A34599. DR PIR: S19397; JFBYA1. XX RN [1] RA Passmore S., Elble R., Tye B.-K. RT A protein involved in minichromosome maintenance in RT yeast binds a transcriptional enhancer conserved in eukaryotes RL Genes Dev. 3:921-935 (1989). XX // AC T00502 XX ID T00502 XX DT 26.01.93 (created); hse. XX FA MEB-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 115 kDa (SDS) XX FF binds to metal response elements XX RN [1] RA Labbe S., Prevost J., Remondelli P., Leone A., Seguin C. RT A nuclear factor binds to the metal regulatory elements RT of the mouse gene encoding metallothionein-I RL Nucleic Acids Res. 19:4225-4231 (1991). XX // AC T00503 XX ID T00503 XX DT 26.01.93 (created); hse. XX FA MEB-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 115 kDa (SDS) XX FF binds to metal response elements XX RN [1] RA Labbe S., Prevost J., Remondelli P., Leone A., Seguin C. RT A nuclear factor binds to the metal regulatory elements RT of the mouse gene encoding metallothionein-I RL Nucleic Acids Res. 19:4225-4231 (1991). XX // AC T00504 XX ID T00504 XX DT 15.10.92 (created); ewi. XX FA mediating factor XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; OC lepidoptera; bombycoidea; bombycidae XX RN [1] RA Matsuno K., Suzuki T., Takiya S., Suzuki Y. RT Complex Formation with the Fibroin Gene Enhancer through RT a Protein-Protein Interaction Analyzed by a Modified DNA-binding Assay RL J. Biol. Chem. 264:4599-4604 (1989). XX // AC T00505 XX ID T00505 XX DT 21.10.92 (created); ewi. DT 14.02.97 (updated); ewi. XX FA MEF-2 XX SY MEF-2A; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO D-MEF2 (Drosophila) XX CL C0014; MADS; 4.3.1.1.1.1. XX SZ 498 AA; 53.7 kDa (cDNA) XX SQ MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST SQ DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCENPDADDYFEHSPLSEDRFIKLNE SQ DSDFIFKRGPPGFPPQNFSMSVTVPVTSPNPLSDTNPGSSLVSPSLAASSTLAETSMLSP SQ PPATLHRNVSPGAPQRPPSTGSASGMLSTTDLTVPNGAGNSPVGNGFVNSRASPNLIGNT SQ GANSLGKVMPTKSPPPPGGGSLGMNSRKPDLRVAIPPSSKGMMPPLSEEEELELNAQRIS SQ SSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFTSPGMLSLG SQ QASAWQEHHLGQTTLSSLVAGGQLSQGSNLSINTNQNINIKSEPISPPRDRMTPSGFQHH SQ HHHPQQQPPPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPANT SQ EDRESPSVKRMRMDTWVT XX SC conceptually translated from EMBL/GenBank/DDBJ #U30823 XX FT 3 57 MADS box FT 58 86 MEF2 domain FT 139 179 serine-/threonine-rich region (17/41) FT 424 439 glutamine-/proline-rich region (15/16) XX SF in skeletal and heart muscle cells, MEF-2 recognizes SF the same sequence motif [3]; SF MEF-2 in brain binds to an extended sequence, possible SF due to interaction with additional factors [3]; XX CP myogenic cells, brain [1]; XX FF involved in myogenesis [5]; FF cooperates with myogenic bHLH factors [5]; FF induces MyoD [5]; FF induced by myogenin [7]; XX IN T00526; MyoD; mouse, Mus musculus. IN T00528; myogenin; mouse, Mus musculus. IN T01537; MRF4; mouse, Mus musculus. XX MX M00006; V$MEF2_01 MX M00231; V$MEF2_02 MX M00232; V$MEF2_03 MX M00233; V$MEF2_04 XX BS R03583; AS$MEF2_01; Quality: 6 BS R03586; CHICK$CTNT_05; Quality: 6; chick, Gallus gallus BS R04212; HS$PGAMM_01; Quality: 4; human, Homo sapiens BS R02201; MEF2$CONS; Quality: 6 BS R00244; MOUSE$MCK_05; Quality: 1; mouse, Mus musculus BS R03585; MOUSE$MCK_07; Quality: 6; mouse, Mus musculus BS R03587; RAT$AMHC_03; Quality: 6; rat, Rattus norvegicus BS R03588; RAT$AMHC_04; Quality: 6; rat, Rattus norvegicus BS R03589; RAT$MHC_02; Quality: 6; rat, Rattus norvegicus BS R03584; RAT$MLCC_01; Quality: 6; rat, Rattus norvegicus XX DR EMBL: U30823; MM30823(r). XX RN [1] RA Yu Y.-T., Breitbart R. E., Smoot L. B., Lee Y., Mahdavi V., Nadal-Ginard B. RT Human myocyte-specific enhancer factor 2 comprises RT a group of tissue-restricted MADS box transcription factors RL Genes Dev. 6:1783-1798 (1992). RN [2] RA Gossett L. A., Kelvin D. J., Sternberg E. A., Olson E. N. RT A new myocyte-specific enhancer-binding factor that RT recognizes a conserved element associated with multiple RT muscle-specific genes RL Mol. Cell. Biol. 9:5022-5033 (1989). RN [3] RA Andres V., Cervera M., Mahdavi V. RT Determination of the consensus binding site for MEF2 RT expressed in muscle and brain reveals tissue-specific sequence constraints RL J. Biol. Chem. 270:23246-23249 (1995). RN [4] RA Molkentin J. D., Black B. L., Martin J. F., Olson E. N. RT Cooperative activation of muscle gene expression by RT MEF2 and myogenic bHLH proteins RL Cell 83:1125-1136 (1995). RN [5] RA Kaushal S., Schneider J. W., Nadal-Ginard B., Mahdavi V. RT Activation of the myogenic lineage by MEF2A, a factor RT that induces and cooperates with MyoD RL Science 266:1236-1240 (1994). RN [6] RA Fickett J. W. RT Quantitative discrimination of MEF2 sites RL Mol. Cell. Biol. 16:437-441 (1996). RN [7] RA Cserjesi P., Olson E. N. RT Myogenin induces the myocyte-specific enhancer binding RT factor MEF-2 independently of other muscle-specific gene products RL Mol. Cell. Biol. 11:4854-4862 (1991). XX // AC T00506 XX ID T00506 XX DT 15.10.92 (created); ewi. XX FA MEF1 XX SY MyoD1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; . XX CP myocytes XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00405; IEBP1; rat, Rattus norvegicus. IN T00433; ITF-2; human, Homo sapiens. IN T00524; MyoD; clawed frog, Xenopus laevis. IN T00525; MyoD; human, Homo sapiens. IN T00527; MyoD; monkey, Cercopithecus aethiops. IN T00674; E47; rat, Rattus norvegicus. IN T00675; E12; rat, Rattus norvegicus. IN T01128; MyoD; chick, Gallus gallus. IN T01787; E12; clawed frog, Xenopus laevis. IN T01788; E47; mouse, Mus musculus. XX BS R00240; MOUSE$MCK_01; Quality: 6; mouse, Mus musculus BS R00242; MOUSE$MCK_03; Quality: 6; mouse, Mus musculus BS R00245; MOUSE$MCK_06; Quality: 6; mouse, Mus musculus BS R02208; MYOD$CONS; Quality: 6 XX RN [1] RA Buskin J. N., Hauschka S. D. RT Identification of a Myocyte Nuclear Factor That Binds RT to the Muscle-Specific Enhancer of the Mouse Muscle Creatine Kinase Gene RL Mol. Cell. Biol. 9:2627-2640 (1989). RN [2] RA Nikovits jr. W., Mar J. H., Ordahl C. P. RT Muscle-Specific Activity of the Skeletal Troponin RT I Promoter Requires Interaction between Upstream Regulatory RT Sequences and Elements Contained within the First Transcribed Exon RL Mol. Cell. Biol. 10:3468-3482 (1990). XX // AC T00507 XX ID T00507 XX DT 12.03.93 (created); ewi. XX FA MF3 XX SY muscle factor 3; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CP muscle XX FF single-stranded DNA-binding protein XX BS R00031; CHICK$AAC_03; Quality: 1; chick, Gallus gallus BS R02075; CHICK$AAC_08; Quality: 4; chick, Gallus gallus BS R00241; MOUSE$MCK_02; Quality: 6; mouse, Mus musculus XX RN [1] RA Santoro I. M., Yi T.-M., Walsh K. RT Identification of single-stranded-DNA-binding proteins RT that interact with muscle gene elements RL Mol. Cell. Biol. 11:1944-1953 (1991). XX // AC T00508 XX ID T00508 XX DT 15.10.92 (created); ewi. XX FA alphaMHCBF1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01168; RAT$AMHC_01; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Markham B. E., Bahl J. J., Gustafson T. A., Morkin E. RT Interaction of a Protein Factor within a Thyroid Hormone-sensitive RT Region of Rat alpha-Myosin Heavy Chain Gene RL J. Biol. Chem. 262:12856-12862 (1987). XX // AC T00509 XX ID T00509 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA MIG1 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0001; CH; 2.3.3.0.3. XX SZ 504 AA; 56 kDa (gene) XX SQ MQSPYPMTQVSNVDDGSLLKESKSKSKVAAKSEAPRPHACPICHRAFHRLEHQTRHMRIH SQ TGEKPHACDFPGCVKRFSRSDELTRHRRIHTNSHPRGKRGRKKKVVGSPINSASSSATSI SQ PDLNTANFSPPLPQQHLSPLIPIAIAPKENSSRSSTRKGRKTKFEIGESGGNDPYMVSSP SQ KTMAKIPVSVKPPPSLALNNMNYQTSSASTALSSLSNSHSGSRLKLNALSSLQMMTPIAS SQ SAPRTVFIDGPEQKQLQQQQNSLSPRYSNTVILPRPRSLTDFQGLNNANPNNNGSLRAQT SQ QSSVQLKRPSSVLSLNDLLVGQRNTNESDSDFTTGGEDEEDGLKDPSNSSIDNLEQDYLQ SQ EQSRKKSKTSTPTTMLSRSTSGTNLHTLGYVMNQNHLHFSSSSPDFQKELNNRLLNVQQQ SQ QQEQHTLLQSQNTSNQSQNQNQNQMMASSSSLSTTPLLLSPRVNMINTAISTQQTPISQS SQ DSQVQELETLPPIRSLPLPFPHMD XX SC SwissProt #P27705 XX SF 2 zinc finger motifs SF glutamine-rich region XX FF involved in glucose repression; FF recognizes GC boxes, high affinity binding is mediated FF by adjacent AT boxes by allowing appropriate bending of the DNA XX MX M00061; F$MIG1_01 XX BS R04153; Y$FBP1_02; Quality: 6; yeast, Saccharomyces cerevisiae BS R04156; Y$FPS1_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R04145; Y$GAL1_15; Quality: 2; yeast, Saccharomyces cerevisiae BS R04146; Y$GAL3_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R04147; Y$GAL4_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R04155; Y$HAP4_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R04149; Y$MAL2R_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R04150; Y$MAL61_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R04151; Y$MAL61_04; Quality: 2; yeast, Saccharomyces cerevisiae BS R04152; Y$MAL63_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R04148; Y$MEL1_02; Quality: 6; yeast, Saccharomyces cerevisiae BS R04154; Y$PDC1_02; Quality: 6; yeast, Saccharomyces cerevisiae BS R02024; Y$SUC2_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R02025; Y$SUC2_02; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: X55734; SCMIG1(g). DR SwissProt: P27705; MIG1_YEAST. DR PIR: S17248; S17248. XX RN [1] RA Lundin M., Nehlin J. O., Ronne H. RT Importance of a flanking AT-rich region in target RT site recognition by the GC box-binding zinc finger protein MIG1 RL Mol. Cell. Biol. 14:1979-1985 (1994). RN [2] RA Nehlin J. O., Ronne H. RT Yeast MIG1 repressor is related to the mammalian early RT growth response and Wilms' tumor finger proteins RL EMBO J. 9:2891-2898 (1990). XX // AC T00510 XX ID T00510 XX DT 09.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA MOK-2 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; . XX SZ 201 AA XX SQ MAEKPYKCDKCGKGFTRSSSLLVHHSLHTGEKPFKCDRCGKGFSQSSKLHIHKRVHTGEK SQ PYACEECGMSFSQRSNLHIHQRVHTGERPYKCGECGKGFSQSSNLHIHRCTHTGEKPYQC SQ YECGKGFSQSSDLRIHLRVHTGEKPYHCGKCGQGFSQSSKLLIHQRVHTGEKPYECSKCG SQ KGFSQSSNLHIHQRVHRKELH XX SC SwissProt #P24399 XX SF 7 zinc finger motifs XX CP brain (high level), testis (moderate) XX DR EMBL: M32057; MMMOK2(r). DR SwissProt: P24399; MOK2_MOUSE. XX RN [1] RA Ernoult-Lange M., Kress M., Hamer D. RT A gene that encodes a protein consisting solely of RT zinc finger domains is preferentially expressed in transformed mouse cells RL Mol. Cell. Biol. 10:418-421 (1990). XX // AC T00511 XX ID T00511 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA MR XX SY mineralocorticoid receptor; mineralocorticosteroid receptor; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.1.1.2. XX SZ 981 AA; 106.6 kDa (cDNA) XX SQ METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNST SQ QGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYD SQ QQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAI SQ VKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPS SQ VENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSP SQ ANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVV SQ PSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISP SQ SSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPG SQ FDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSP SQ RDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRP SQ SKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACR SQ LQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSAL SQ VPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKW SQ AKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQS SQ AMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKEL SQ RKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEI SQ ITDQLPKVESGNAKPLYFHRK XX SC SwissProt #P22199 XX FT 1 602 region A/B FT 603 670 regions C, DNA-binding domain (DBD) FT 671 730 region D FT 731 981 region E, hormone-binding domain (HBD) XX SF the DBD exhibits 94% homology with that of GR [1]; SF binds glucocorticoids and mineralcorticoids with equal affinity [1]; XX FF activator, may mediate mineralocorticoid as well as FF glucocorticoid-induced transcription [1]; FF mineralocorticoids (aldosterone) are the physiological FF ligand in tissues where glucocorticoids are modified FF to non-binding analogs by 11beta-hydroxysteroid dehydrogenase [3]; FF ether aminophosphoglycerides have been suggested to FF stabilize ligand binding, but to inhibit receptor activation [2]; XX IN T00511; MR; rat, Rattus norvegicus. IN T00992; Hsp90; human, Homo sapiens. XX BS R02203; MR$CONS; Quality: 6 XX DR EMBL: M36074; RNMCR(r). DR SwissProt: P22199; MCR_RAT. DR PIR: A41401; A41401. XX RN [1] RA Arriza J. L., Weinberger C., Cerelli G., Glaser T. RA M., Handelin B. L., Housman D. E., Evans R. M. RT Cloning of human mineralocorticoid receptor complementary RT DNA: structural and functional kinship with the glucocorticoid receptor RL Science 237:268-275 (1987). RN [2] RA Schulman G., Bodine P. V., Litwack G. RT Modulators of th eglucocorticoid receptor also regulate RT mineralcorticoid receptor function RL Biochemistry 31:1734-1741 (1992). RN [3] RA Funder J. W., Pearce P. T., Smith R., Smith A.I. RT Mineralocorticoid action: target tissue specificity RT is enzyme, not receptor, mediated RL Science 242:583-585 (1988). RN [4] RA Ikeda U., Hyman R., Smith T. W., Medford R. M. RT Aldosterone-mediated regulation of Na+,K+-ATPase gene RT expression in adult and neonatal rat cardiocytes RL J. Biol. Chem. 266:12058-12066 (1991). RN [5] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). XX // AC T00512 XX ID T00512 XX DT 21.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA MRF4 XX SY Myf-6 (human); herculin (mouse); XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; 1.2.2.0.4. XX SZ 242 AA; 27.0 kDa (cDNA) XX SQ MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPQEAGSDSSGEE SQ HVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRT SQ VANPNQRLPKVEILRSAINYIERLQDLLHRLDQQEKMQELGVDPYSYKPKQEILEGADFL SQ RTCSPQWPSVSDHSRGLVITAKEGGASVDASASSSLQRLSSIVDSISSEERKLPSVEEVV SQ EK XX SC SwissProt #P19335 XX FT 4 60 acidic region FT 10 30 major transcription activation domain FT 94 105 basic region FT 106 145 helix-loop-helix domain FT 208 235 serine-rich region FT 99 99 threonine-phosphorylation by PKC inhibits DNA-binding [5]; XX SF efficient DNA-binding only after heterodimerization with (e.g.) E12 [4]; SF strong cooperation between N- and C-terminal domains SF for MRF4-specific transcriptional activation [7]; SF phosphorylation at several Ser and Thr by PKA and PKC in vitro and in vivo XX CP myogenic cells XX FF myogenic factor, transcriptional activator [9]; FF activates MyoD and myogenin genes; FF expression repressed by MyoD or myogenin [9]; FF it is transiently expressed after myogenin, before FF MyoD, and reappears during late stage of skeletal muscle development [2]; FF during limb bud development, it is expressed just at these late stages; FF it is suggested to play a role in maintaining the differentiated stage [2]; FF down-regulated by bFGF [5]; XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00512; MRF4; rat, Rattus norvegicus. IN T00675; E12; rat, Rattus norvegicus. IN T01787; E12; clawed frog, Xenopus laevis. IN T01789; SCBPgamma; rat, Rattus norvegicus. IN T01790; SCBPalpha; rat, Rattus norvegicus. IN T01791; SCBPbeta; rat, Rattus norvegicus. XX BS R00242; MOUSE$MCK_03; Quality: 2; mouse, Mus musculus BS R02898; QUAIL$STN1_01; Quality: 2; quail, Coturnix coturnix XX DR EMBL: M84685; RNMRF4A(g). DR EMBL: M27151; RNMRF4AA(r). DR SwissProt: P19335; MYF6_RAT. DR PIR: A34221; A34221. DR PIR: JC1233; JC1233. XX RN [1] RA Mak K.-L., To R. Q., Kong Y., Konieczny S. F. RT The MRF4 activation domain is required to induce muscle-specific RT gene expression RL Mol. Cell. Biol. 12:4334-4346 (1992). RN [2] RA Hinterberger T. J., Sassoon D. A., Rhodes S. J., Konieczny S. F. RT Expression of the muscle regulatory factor MRF4 during RT somite and skeletal myofiber development RL Develop. Biol. 147:144-156 (1991). RN [3] RA Hinterberger T. J., Mays J. L., Konieczny S. F. RT Structure and myofiber-specific expression of the RT rat muscle regulatory gene MRF4 RL Gene 117:201-207 (1992). RN [4] RA Lin H., Konieczny S. F. RT Identification of MRF4, myogenin, and E12 oligomer RT complexes by cheical cross-linking and two-dimensional gel electrophoresis RL J. Biol. Chem. 267:4773-4780 (1992). RN [5] RA Hardy S., Kong Y., Konieczny S. F. RT Fibroblast growth factor inhibits MRF4 activity independently RT of the phosporylation status of a conserved threonine RT residue within the DNA-binding domain RL Mol. Cell. Biol. 13:5943-5956 (1993). RN [6] RA Chakraborty T., Brennan T., Olson E. RT Differential trans-activation of a muscle-specific RT enhancer by myogenic helix-loop-helix proteins is separable from DNA binding RL J. Biol. Chem. 266:2878-2882 (1991). RN [7] RA Chakraborty T., Olson E. N. RT Domains outside of the DNA-binding domain impart target RT gene specificity to myogenin and MRF4 RL Mol. Cell. Biol. 11:6103-6108 (1991). RN [8] RA Yutzey K. E., Rhodes S. J., Konieczny S. F. RT Differential trans activation associated with the RT muscle regulatory factors MyoD1, myogenin, and MRF4 RL Mol. Cell. Biol. 10:3934-3944 (1990). RN [9] RA Rhodes S. J., Konieczny S. F. RT Identification of MRF4: a new member of the muscle RT regulatory factor gene family RL Genes Dev. 3:2050-2061 (1989). XX // AC T00513 XX ID T00513 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA MR XX SY mineralocorticoid receptor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); 2.1.1.1.2. XX SZ 984 AA; 106.9 kDa (cDNA), 115, 119, 125 kDa (SDS) [2]; XX SQ METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST SQ QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE SQ QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAI SQ VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN SQ AENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP SQ ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP SQ SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD SQ SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF SQ DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR SQ DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS SQ KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL SQ QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN SQ TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV SQ VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM SQ HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI SQ KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML SQ VEIISDQLPKVESGNAKPLYFHRK XX SC SwissProt #P08235 XX FT 1 601 region A/B FT 602 669 region C, DNA-binding domain (DBD) FT 670 733 region D FT 734 984 hormone-binding domain (HBD) XX SF the DBD exhibits 94% homology with that of GR [1]; SF binds glucocorticoids and mineralcorticoids with equal affinity [1]; XX FF activator, may mediate mineralocorticoid as well as FF glucocorticoid-induced transcription [1]; XX BS R02203; MR$CONS; Quality: 1 XX DR EMBL: M16801; HSMCR(r). DR SwissProt: P08235; MCR_HUMAN. DR PIR: A29513; A29513. XX RN [1] RA Arriza J. L., Weinberger C., Cerelli G., Glaser T. RA M., Handelin B. L., Housman D. E., Evans R. M. RT Cloning of human mineralocorticoid receptor complementary RT DNA: structural and functional kinship with the glucocorticoid receptor RL Science 237:268-275 (1987). RN [2] RA Alnemri E. S., Maksymowych A. B., Robertson N.M., Litwack G. RT Overexpression and characterization of the human mineralocorticoid receptor RL J. Biol. Chem. 266:18072-18081 (1991). RN [3] RA Binart N., Lombes M., Rafestin-Oblin M.-E., Baulieu E.-E. RT Characterization of human mineralocoticosteroid receptor RT expressed in the baculovirus system RL Proc. Natl. Acad. Sci. USA 88:10681-10685 (1991). RN [4] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). XX // AC T00515 XX ID T00515 XX DT 26.01.93 (created); hse. DT 08.04.94 (updated); hwi. XX FA MTF-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX FF binds to metal response elements (MRE), related to Sp1 XX BS R01022; MOUSE$MT1_02; Quality: 6; mouse, Mus musculus BS R02204; MTF1$CONS; Quality: 6 XX DR EMBL: X71327; MMMTF1(r). XX RN [1] RA Culotta V. C., Hamer D. H. RT Fine mapping of a mouse metallothionein gene metal response element RL Mol. Cell. Biol. 9:1376-1380 (1989). RN [2] RA Mueller P. R., Salser S. J., Wold B. RT Constitutive and metal-inducible protein: DNA interactions RT at the mouse metallothionein I promoter examined by RT in in vivo and in vitro footprinting RL Genes Dev. 2:412-427 (1988). XX // AC T00516 XX ID T00516 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA mtTF1 XX SY mitochondrial transcription factor 1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 24.4 kDa (cDNA) XX SQ MAFLRSMWGVLSALGRSGAELCTGCGSRLRSPFSFVYLPRWFSSVLASCPKKPVSSYLRF SQ SKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKEEISRFKEQ SQ LTPSQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQE SQ KLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIKKQRK SQ YGAEEC XX SC SwissProt #Q00059 XX SF HMG XX CP mitochondria XX FF mitochondrial transcription factor XX BS R02205; MTTF1$CONS; Quality: 6 XX DR EMBL: X64269; HSMTFDNA(g). DR SwissProt: Q00059; MTF1_HUMAN. XX RN [1] RA Parisi M. A., Clayton D. A. RT Similarity of human mitochondrial transcription factor RT 1 to high mobility group proteins RL Science 252:965-969 (1991). XX // AC T00517 XX ID T00517 XX DT 15.10.92 (created); ewi. DT 25.01.93 (updated); hse. XX FA myc-CF1 XX SY CF1; common factor 1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP ubiquitous XX BS R02133; CF1$CONS; Quality: 1 BS R01161; MOUSE$CMYC_02; Quality: 6; mouse, Mus musculus BS R02999; MOUSE$CMYC_05; Quality: 6; mouse, Mus musculus BS R00848; MOUSE$IGH_14; Quality: 6; mouse, Mus musculus BS R03000; MOUSE$SAACT_01; Quality: 6; mouse, Mus musculus XX RN [1] RA Kakkis E., Riggs K. J., Gillespie W., Calame K. RT A transcriptional repressor of c-myc RL Nature 339:718-721 (1989). RN [2] RA Riggs K. J., Merrell K. T., Wilson G., Calame K. RT Common factor 1 is a transcriptional activator which RT binds in the c.myc promoter, the skeletal alpha-actin RT promoter, and the immunoglobulin heavy-chain enhancer RL Mol. Cell. Biol. 11:1765-1769 (1991). RN [3] RA Riggs K. J., Merrell K. T., Wilson G., Calame L. RT Common factor 1 is a transcriptional activator which RT binds in the c-myc promoter, the skeletal alpha-actin RT promoter, and the immunoglobulin heavy-chain enhancer RL Mol. Cell. Biol. 11:1765-1769 (1991). XX // AC T00518 XX ID T00518 XX DT 15.10.92 (created); ewi. XX FA myc-PRF XX SY myc-PCF; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX FF repressor XX BS R01160; MOUSE$CMYC_01; Quality: 6; mouse, Mus musculus BS R02231; PCF$CONS; Quality: 6 XX RN [1] RA Kakkis E., Riggs K. J., Gillespie W., Calame K. RT A transcriptional repressor of c-myc RL Nature 339:718-721 (1989). XX // AC T00519 XX ID T00519 XX DT 20.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Myf-3 XX SY MEF-1 (mouse); MyoD1 (mouse); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0010; bHLH; 1.2.2.0.1. XX SZ 319 AA; 34.5 kDa (cDNA) XX SQ MELLSPPLRDVDLTAPDGSLCSFATTDDFYDDPCFDSPDLRFFEDLDPRLMHVGALLKPE SQ EHSHFPAAVHPAPGAREDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERR SQ RLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQDAAPPGAAAFYAP SQ GPLPPGRGGEHYSGDSDASSPRSNCSDGMMDYSGPPSGARRRNCYEGAYYNEAPSEPRPG SQ KSAAVSSLDYLSSIVERISTESPAAPALLLADVPSESPPRRQEAAAPSEGESSGDPTQSP SQ DAAPQCPAGANPNPIYQVL XX SC SwissProt #P15172 XX CP myogenic cells XX BS R02418; HS$MLC_01; Quality: 6; human, Homo sapiens BS R02419; HS$MLC_02; Quality: 6; human, Homo sapiens BS R02208; MYOD$CONS; Quality: 6 XX DR EMBL: X17650; HSMYF3(r). DR EMBL: X56677; HSMYOD(r). DR SwissProt: P15172; MYF3_HUMAN. DR PIR: S06947; S06947. XX RN [1] RA Rosenthal N., Berglund E. B., Wentworth B. M., Donoghue RA M., Winter B., Bober E., Braun T., Arnold H.-H. RT A highly conserved enhancer downstream of the human RT MLC1/3 locus is a target for multiple myogenic determination factors RL Nucleic Acids Res. 18:6239 (1990). XX // AC T00520 XX ID T00520 XX DT 20.11.92 (created); ewi. DT 14.02.97 (updated); ewi. XX FA Myf-4 XX SY MyoG; myogenin; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0010; bHLH; 1.2.2.0.2. XX SZ 224 AA; 25.0 kDa (cDNA) XX SQ MELYETSPYFYQEPRFYDGENYLPVHLQGFEPPGYERTELTLSPEAPGPLEDKGLGTPEH SQ CPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVE SQ ILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPGVPSECSSHSASCSPEWGSALEFS SQ ANPGDHLLTADPTDAHNLHSLTSIVDSITVEDVSVAFPDETMPN XX SC SwissProt #P15173 XX FT 82 93 basic region FT 94 133 helix-loop-helix domain FT 132 146 putative leucine repeat (L3) XX SF Myf-4 does not heterodimerize with any of the other myogenic factors [5]; XX CP myogenic cells; skeletal muscle cells XX FF myogenic transcription factor; FF coexpressed with MyoD in the developing limb bud [3]; FF pre-existing MEF-2 activates Myf-4 expression [1]; XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00432; ITF-1; human, Homo sapiens. IN T00433; ITF-2; human, Homo sapiens. IN T01503; HEB; human, Homo sapiens. XX BS R02418; HS$MLC_01; Quality: 6; human, Homo sapiens BS R02419; HS$MLC_02; Quality: 6; human, Homo sapiens XX DR EMBL: X17651; HSMYF4(r). DR EMBL: X62155; HSMYF4G(g). DR SwissProt: P15173; MYF4_HUMAN. DR PIR: A41128; A41128. DR PIR: S06948; S06948. DR PIR: S27295; S27295. XX RN [1] RA Buchberger A., Ragge K., Arnold H.-H. RT The myogenin gene is activated during myocyte differentiation RT by pre-existing, not newly synthesized transcription factor MEF-2 RL J. Biol. Chem. 269:17289-17296 (1994). RN [2] RA Salminen A., Braun T., Buchberger A., Juers S., Winter B., Arnold H. H. RT Transcription of the muscle regulatory gene Myf4 is RT regulated by serum components, peptide growth factors RT and signalling pathways involving G proteins RL J. Cell Biol. 115:905-917 (1991). RN [3] RA Ott M.-O., Bober E., Lyons G., Arnold H.-H., Buckingham M. RT Early expression of the myogenic regulatory gene, RT myf-5, in precursor cells of skeletal muscle in the mouse embryo RL Development 111:1097-1107 (1991). RN [4] RA Rosenthal N., Berglund E. B., Wentworth B. M., Donoghue RA M., Winter B., Bober E., Braun T., Arnold H.-H. RT A highly conserved enhancer downstream of the human RT MLC1/3 locus is a target for multiple myogenic determination factors RL Nucleic Acids Res. 18:6239 (1990). RN [5] RA Braun T., Arnold H. H. RT The four helix-loop-helix proteins Myf3-Myf6 exhibit RT similar hetero-dimerization and DNA binding properties RL Nucleic Acids Res. 19:5645-5651 (1991). RN [6] RA Braun T., Bober E., Buschhausen-Denker G., Kotz S., RA Grzeschik K., Arnold H. H. RT Differential expression of myogenic determination RT genes in muscle cells: possible autoactivation by the Myf gene products RL EMBO J. 8:3617-3625 (1989). XX // AC T00521 XX ID T00521 XX DT 21.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Myf-5 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0010; bHLH; 1.2.2.0.3. XX SZ 255 AA; 28.4 kDa (cDNA) XX SQ MDVMDGCQFSPSEYFYDGSCIPSPEGEFGDEFVPRVAAFGAHKAELQGSDEDEHVRAPTG SQ HHQAGHCLMWACKACKRKSTTMDRRKAATMRERRRLKKVNQAFETLKRCTTTNPNQRLPK SQ VEILRNAIRYIESLQELLREQVENYYSLPGQSCSEPTSPTSNCSDGMPECNSPVWSRKSS SQ TFDSIYCPDVSNVYATDKNSLSSLDCLSNIVDRITSSEQPGLPLQDLASLSPVASTDSQP SQ RTPGASSSRLIYHVL XX SC SwissProt #P13349 XX FT 2 53 acidic region, weak transcription activating region FT 84 95 basic region FT 96 135 helix-loop-helix domain FT 135 255 strong transcription activating region FT 156 167 conserved serine-/threonine-rich region FT 202 216 conserved serine-/threonine-rich region XX SF heterodimerization with E12 enhances DNA-binding and SF transcription activation [3]; SF no heterodimerization with other myogenic factors [5]; SF N- and C-terminal regions have to cooperate for full trans-activation [3]; XX CP myogenic cells XX FF muscle-specific transcription activator [7]; FF induces myogenic differentiation in vitro and in vivo [7]; FF different expression pattern than MyoD [6]; FF down-regulated by PKA [1] or E1A [2]; XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00432; ITF-1; human, Homo sapiens. IN T00433; ITF-2; human, Homo sapiens. IN T00521; Myf-5; human, Homo sapiens. IN T00675; E12; rat, Rattus norvegicus. IN T01787; E12; clawed frog, Xenopus laevis. XX BS R02418; HS$MLC_01; Quality: 6; human, Homo sapiens BS R02419; HS$MLC_02; Quality: 6; human, Homo sapiens BS R02898; QUAIL$STN1_01; Quality: 6; quail, Coturnix coturnix XX DR EMBL: X14894; HSMYF5(r). DR SwissProt: P13349; MYF5_HUMAN. DR PIR: S04105; S04105. XX RN [1] RA Winter B., Braun T., Arnold H. H. RT cAMP-dependent protein kinase represses myogenic differentiation RT and the activity of the muscle-specific helix-loop-helix RT transcription factors Myf-5 and MyoD RL J. Biol. Chem. 13:9869-9878 (1993). RN [2] RA Braun T., Bober E., Arnold H. H. RT Inhibition of muscle differentiation by the adenovirus RT E1a protein: Repression of the transcriptional activating RT function of the HLH protein Myf-5 RL Genes Dev. 6:888-902 (1992). RN [3] RA Winter B., Braun T., Arnold H.-H. RT Co-operativity of functional domains in the muscle-specific RT transcription factor Myf-5 RL EMBO J. 11:1843-1855 (1992). RN [4] RA Braun T., Winter B., Bober E., Arnold H. H. RT Transcriptional activation domain of the muscle-specific RT gene-regulatory protein myf5 RL Nature 346:663-665 (1990). RN [5] RA Braun T., Arnold H. H. RT The four helix-loop-helix proteins Myf3-Myf6 exhibit RT similar hetero-dimerization and DNA binding properties RL Nucleic Acids Res. 19:5645-5651 (1991). RN [6] RA Braun T., Bober E., Buschhausen-Denker G., Kotz S., RA Grzeschik K., Arnold H. H. RT Differential expression of myogenic determination RT genes in muscle cells: possible autoactivation by the Myf gene products RL EMBO J. 8:3617-3625 (1989). RN [7] RA Braun T., Buschhausen-Denker G., Bober E., Tannich E., Arnold H. H. RT A novel human muscle factor related to but distinct RT from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts RL EMBO J. 8:701-709 (1989). XX // AC T00522 XX ID T00522 XX DT 20.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Myf-6 XX SY MRF-4 (rat); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0010; bHLH; 1.2.2.0.4. XX SZ 242 AA; 27.0 kDa (cDNA) XX SQ MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPPEAGSDSSGEE SQ HVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRT SQ VANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPFSYRPKQENLEGADFL SQ RTCSSQWPSVSDHSRGLVITAKEGGASIDSSASSSLRCLSSIVDSISSEERKLPCVEEVV SQ EK XX SC SwissProt #P23409 XX FT 4 60 acidic region FT 10 30 major transcription activation domain [3]; FT 94 105 basic region FT 106 145 helix-loop-helix domain FT 208 235 serine-rich region XX SF for efficient DNA-binding, Myf-6 has to heterodimerize with (e. g.) E12 [2]; SF it does not heterodimerize with any of the other myogenic factors [2]; XX CP myogenic cells XX FF myogenic factor, transcriptional activator XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00432; ITF-1; human, Homo sapiens. IN T00433; ITF-2; human, Homo sapiens. XX BS R02418; HS$MLC_01; Quality: 6; human, Homo sapiens XX DR EMBL: X52011; HSMYF6A(r). DR SwissProt: P23409; MYF6_HUMAN. DR PIR: S12385; S12385. XX RN [1] RA Rosenthal N., Berglund E. B., Wentworth B. M., Donoghue RA M., Winter B., Bober E., Braun T., Arnold H.-H. RT A highly conserved enhancer downstream of the human RT MLC1/3 locus is a target for multiple myogenic determination factors RL Nucleic Acids Res. 18:6239 (1990). RN [2] RA Braun T., Arnold H. H. RT The four helix-loop-helix proteins Myf3-Myf6 exhibit RT similar hetero-dimerization and DNA binding properties RL Nucleic Acids Res. 19:5645-5651 (1991). RN [3] RA Braun T., Bober E., Winter B., Rosenthal N., Arnold H. H. RT Myf-6, a new member of the human gene family of myogenic RT determination factors: evidence for a gene cluster on chromosome 12 RL EMBO J. 9:821-831 (1990). XX // AC T00523 XX ID T00523 XX DT 21.10.92 (created); ewi. DT 14.02.97 (updated); ewi. XX FA Myn XX SY Max (human); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0012; bHLH-ZIP; 1.3.2.2.1. XX SZ 160 AA; 18.3 kDa (cDNA), 20 kDa, 22 kDa (SDS) XX SQ MSDNDDIEVESDEEQARFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASR SQ AQILDKATEYIQYMRRKNDTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDN SQ SLYTNAKGGTISAFDGGSDSSSESEPEEPQSRKKLRMEAS XX SC SwissProt #P28574 XX FT 2 2 Ser-phosphorylation by CKII [6]; FT 3 14 acidic region FT 11 11 Ser-phosphorylation by CKII [6]; FT 13 21 missing in Max1 FT 24 35 basic region FT 36 75 helix-loop-helix domain FT 74 102 leucine zipper (MHL3) XX SF solution of the crystal structure revealed that the SF HLH motifs form a four-helix-bundle with all helices SF in parallel orientation [3]; SF helix 2 is prolonged by the alpha-helically folded leucine zipper SF heterodimers with c-Myc or Mad have higher DNA-binding affinity [5]; SF the leucine zipper is specifically required for heterodimerization [5]; XX FF enhances c-Myc DNA-binding, perturbation of homodimer-binding FF after CKII phosphorylation, but not of Myc/Max-heterodimer [6]; FF in complexes with either Mxi1 or Mad, it represses FF c-Myc or N-Myc effects [2]; XX IN T00140; c-Myc; human, Homo sapiens. IN T00141; c-Myc; chick, Gallus gallus. IN T00142; c-Myc; rat, Rattus norvegicus. IN T00143; c-Myc; mouse, Mus musculus. IN T00523; Myn; mouse, Mus musculus. IN T01445; N-Myc; mouse, Mus musculus. XX BS R02094; AS$MYC_02; Quality: 1 XX DR EMBL: M63903; MMMYN(r). DR SwissProt: P28574; MYN_MOUSE. DR PIR: A38488; A38488. XX RN [1] RA Mukherjee B., Morgenbesser S. D., DePinho R. A. RT Myc family oncoproteins function through a common RT pathway to transform normal cells in culture: cross-interference RT by Max and trans-acting dominant mutants RL Genes Dev. 6:1480-1492 (1992). RN [2] RA Gomez Lahoz E., Xu L., Schreiber-Agus N., DePinho R. A. RT Suppression of Myc, but not E1a, transformation activity RT by Max-associated proteins, Mad and Mxi1 RL Proc. Natl. Acad. Sci. USA 91:5503-5507 (1994). RN [3] RA Ferre-D'Amare A. E., Prendergast G. C., Ziff E. B., Burley S. K. RT Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain RL Nature 363:38-45 (1993). RN [4] RA Prendergast G. C., Hopewell R., Gorham B. J., Ziff E. B. RT Biphasic effect of Max and Myc cotransformation activity RT and dependence on amino- and carboxy-terminal Max functions RL Genes Dev. 6:2429-2439 (1992). RN [5] RA Prendergast G. C., Lawe D., Ziff E. B. RT Association of Myn, the murine homolog of Max, with RT c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation RL Cell 65:395-407 (1991). RN [6] RA Berberich S. J., Cole M. D. RT Casein kinase II inhibits the DNA-binding activity RT of Max homodimers but not Myc/Max heterodimers RL Genes Dev. 6:166-176 (1992). XX // AC T00524 XX ID T00524 XX DT 21.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA MyoD XX SY XMyoD; XX OS clawed frog, Xenopus laevis OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CL C0010; bHLH; 1.2.2.0.1. XX SZ 289 AA; 32.3 kDa (cDNA) XX SQ MELLPPPLRDMEVTEGSLCAFPTPDDFYDDPCFNTSDMSFFEDLDPRLVHVTLLKPEEPH SQ HNEDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERRRLSKVNEAFETLKR SQ YTSTNPNQRLPKVEILRNAIRYIESLQALLHDQDEAFYPVLEHYSGDSDASSPRSNCSDG SQ MMDYNSPPCGSRRRNSYDSSFYSDSPNDSRLGKSSVISSLDCLSSIVERISTQSPSCPVP SQ TAVDSGSEGSPCSPLQGETLSERVITIPSPSNTCTQLSQDPSSTIYHVL XX SC SwissProt #P13904 XX FT 10 45 acidic region (11/36) FT 101 112 basic region FT 113 152 helix-loop-helix domain FT 165 236 serine-/threonine-rich region (24/72) XX SF the heterodimer with E12/E47 is identical with the SF DNA-binding activity EMF1 [6], [4]; XX CP precursors of skeletal muscle cells XX FF myogenic factor, expressed in early response to mesoderm induction [7], [2]; FF in midblastula transition stage: ubiquitous low-level expression [3]; FF for induction of full myogenic differentiation, additional FF factors are required [1]; FF regulated nuclear localization in myogenic cells [4]; XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00404; Id2; mouse, Mus musculus. IN T00432; ITF-1; human, Homo sapiens. IN T00433; ITF-2; human, Homo sapiens. IN T00506; MEF1; mouse, Mus musculus. IN T01212; Id2; human, Homo sapiens. XX BS R02208; MYOD$CONS; Quality: 6 BS R03329; XENLA$AC_04; Quality: 6; clawed frog, Xenopus laevis BS R03330; XENLA$AC_05; Quality: 6; clawed frog, Xenopus laevis XX DR EMBL: M31116; XLMF1(r). DR EMBL: X16106; XLMYODMR(r). DR SwissProt: P13904; MYOD_XENLA. DR PIR: A34783; A34783. DR PIR: S06952; S06952. XX RN [1] RA Hopwood N. D., Gurdon J. B. RT Activation of muscle genes without myogenesis by ectopic RT expression of MyoD in frog embryo RL Nature 347:197-200 (1990). RN [2] RA Harvey R. P. RT Widespread expression of MyoD genes in Xenopus embryos RT is amplified in presumptive muscle as a delayed response RT to mesoderm induction RL Proc. Natl. Acad. Sci. USA 88:9198-9202 (1991). RN [3] RA Rupp R. A. W., Weintraub H. RT Ubiquitous MyoD transcription at the midblastula transition RT precedes induction-independent MyoD expression in RT presumptive mesoderm of Xenopus laevis RL Cell 65:927-937 (1991). RN [4] RA Rashbass J., Taylor M. V., Gurdon J. B. RT The DNA-binding protein E12 co-operates with XMyoD RT in the activation of muscle-specific gene expression in Xenopus embryos RL EMBO J. 11:2981-2990 (1992). RN [5] RA Rupp R. A. W., Snider L., Weintraub H. RT Xenopus embryos regulate the nuclear localization of XMyoD RL Genes Dev. 8:1311-1323 (1994). RN [6] RA Taylor M. V., Gurdon J. B., Hopwood N. D., Towers N., Mohun T. J. RT Xenopus embryos contain a somite-specific, MyoD-like RT protein that binds to a promoter site required for muscle actin expression RL Genes Dev. 5:1149-1160 (1991). RN [7] RA Hopwood N. D., Pluck A., Gurdon J. B. RT MyoD expression in the forming somites is an early RT response to mesoderm induction in Xenopus embryos RL EMBO J. 8:3409-3417 (1989). XX // AC T00525 XX ID T00525 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA MyoD XX SY MEF1; Myf-3; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0010; bHLH; . XX SZ 319 AA; 34,5 kDa (cDNA);45 kDa (SDS) XX SQ MELLSPPLRDVDLTAPDGSLCSFATTDDFYDDPCFDSPDLRFFEDLDPRLMHVGALLKPE SQ EHSHFPAAVHPAPGAREDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERR SQ RLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQDAAPPGAAAFYAP SQ GPLPPGRGGEHYSGDSDASSPRSNCSDGMMDYSGPPSGARRRNCYEGAYYNEAPSEPRPG SQ KSAAVSSLDYLSSIVERISTESPAAPALLLADVPSESPPRRQEAAAPSEGESSGDPTQSP SQ DAAPQCPAGANPNPIYQVL XX SC SwissProt #P15172 XX FT 10 47 acidic region (12/38) FT 102 121 basic region FT 122 162 helix-loop-helix domain FT 189 262 serine-/threonine-rich region (17/74) XX SF MyoD does not heterodimerize with other myogenic factors [7]; XX CP myogenic cells XX FF myogenic transcription factor XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00404; Id2; mouse, Mus musculus. IN T00432; ITF-1; human, Homo sapiens. IN T00433; ITF-2; human, Homo sapiens. IN T00506; MEF1; mouse, Mus musculus. IN T01005; MEF-2; human, Homo sapiens. IN T01212; Id2; human, Homo sapiens. IN T01770; MEF-2D; human, Homo sapiens. IN T01771; MEF-2D; clawed frog, Xenopus laevis. XX BS R02418; HS$MLC_01; Quality: 6; human, Homo sapiens BS R02419; HS$MLC_02; Quality: 6; human, Homo sapiens BS R02208; MYOD$CONS; Quality: 6 XX DR EMBL: X17650; HSMYF3(r). DR EMBL: X56677; HSMYOD(r). DR SwissProt: P15172; MYF3_HUMAN. DR PIR: S06947; S06947. DR Compel: C00028 XX RN [1] RA Weintraub H., Tapscott S. J., Davis R. L., Thayer RA M. J., Adam M. A., Lassar A. B., Miller A. D. RT Activation of muscle-specific genes in pigment, nerve, RT fat, liver, and fibroblast cell lines by forced expression of MyoD RL Proc. Natl. Acad. Sci. USA 86:5434-5438 (1989). RN [2] RA Thayer M. J., Weintraub H. RT Activation and repression of myogenesis in somatic RT cell hybrids: evidence for trans-negative regulation RT of MyoD in primary fibroblasts RL Cell 63:23-32 (1990). RN [3] RA Davis R. L., Cheng P.-F., Lassar A. B., Weintraub H. RT The MyoD DNA binding domain contains a recognition RT code for muscle-specific gene activation RL Cell 60:733-746 (1990). RN [4] RA Murre C., McCaw P. S., Baltimore D. RT A new DNA binding and dimerization motif in immunoglobulin RT enhancer binding, daughterless, MyoD, and myc proteins RL Cell 56:777-783 (1989). RN [5] RA Vaidya T. B., Rhodes S. J., Taparowsky E. J., Konieczny S. F. RT Fibroblast growth factor and transforming growth factor RT beta repress transcription of the myogenic regulatory gene MyoD1 RL Mol. Cell. Biol. 9:3576-3579 (1989). RN [6] RA Tapscott S. J., Davis R. L., Thayer M. J., Cheng P., RA Weintraub H., Lassar A. B. RT MyoD1: a nuclear phosphoprotein requiring a Myc homology RT region to convert fibroblasts to myoblasts RL Science 242:405-411 (1988). RN [7] RA Braun T., Arnold H. H. RT The four helix-loop-helix proteins Myf3-Myf6 exhibit RT similar hetero-dimerization and DNA binding properties RL Nucleic Acids Res. 19:5645-5651 (1991). XX // AC T00526 XX ID T00526 XX DT 15.10.92 (created); ewi. DT 14.05.97 (updated); ewi. XX FA MyoD XX SY MEF1; Myf-3 (human); MyoD1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; 1.2.2.0.1. XX SZ 318 AA; 34.2 kDa (cDNA), 45 kDa (SDS) XX SQ MELLSPPLRDIDLTGPDGSLCSFETADDFYDDPCFDSPDLRFFEDLDPRLVHVGALLKPE SQ EHAHFSTAVHPGPGAREDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERR SQ RLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQDAAPPGAAAFYAP SQ GPLPPGRGSEHYSGDSDASSPRSNCSDGMMDYSGPPSGPRRQNGYDTAYYSEAVRESRPG SQ KSAAVSSLDCLSSIVERISTDSPAAPALLLADAPPESPPGPPEGASLSDTEQGTQTPSPD SQ AAPQCPAGSNPNAIYQVL XX SC SwissProt #P10085 XX FT 1 53 transcription activation domain FT 10 47 acidic region (13/38) FT 57 167 contains recognition site for Hsp90 FT 102 121 basic region FT 122 162 helix-loop-helix domain FT 122 136 helix 1 FT 137 145 loop FT 146 162 helix 2 FT 189 262 serine-/threonine-rich region (20/74) FT 263 311 proline-rich region (12/49) FT 100 112 nuclear localization signal (NLS234) [36]; FT 130 135 nuclear localization signal (NLS6) [36]; XX SF spectroscopic data: CD [46], [29], EPR [46]; SF crystal structure [25]; SF heterodimers with E12/E47 bind more avidly to DNA SF than homodimers [34], [40], [41]; SF the heterodimer is identical to the DNA-binding activity MEF-1 [41]; SF A114 is essential for DNA-binding, T115 for muscle-specific SF transcriptional activation [28]; SF both residues are buried at the protein-DNA interface SF and may determine the conformation at R111 which makes SF a base-specific contact in the major groove [25], [26], [27]; SF L122 discirminates agianst c-Myc binding sites [14]; SF the DNA-binding specificity differs slightly between SF MyoD homodimers and MyoD/E12 or MyoD/E47 heterodimers [45]; SF the HLH dimerization domain forms a parallel four-helix-bundle [46]; SF DNA-binding induces the basic region to adopt alpha-helical SF conformation [46]; SF correct folding may be augmented by hsp90 which, however, SF is not part of the DNA-bound complex [16], [1], [30]; SF KD (homodimer) = 31.2 uM, KD (MyoD/E47) = 0.72 uM, SF KD (MyoD/Id) = 0.7 uM [29]; SF MyoD/Id complexes form heterotetramers with KD (tetramer/dimer) SF = 0.01 uM [29]; SF the trans-activating domain is masked [28]; SF both nuclear localization signal function independently of each other [36]; XX CP proliferating myoblasts and differentiated myotubes XX FF transcriptional activator [33] of muscle-specific genes [7]; FF myogenic master gene product causing myogenic differentiation [3], [4], [5]; FF inhibitor of cell proliferation depending on the HLH domain [9], [31]; FF can partly substitute for Myf-5 and vice versa [24]; FF induced immediately after mesoderm induction between FF the first and second phase of MRF4 expression [5], [20]; FF in regenerating skeletal muscle for at least 2 weeks [10]; FF positive autoregulation [8]; FF positively regulated by thyroid hormone, antagonized FF by an overlapping AP-1 element [13], [21]; FF for onset of MyoD expression, a dephosphorylation step is required [15]; FF negative regulation of MyoD by ras, c-fos, c-jun, FF junB, c-myc [2], [6], [11], [12]; FF the N-terminal part of c-Jun directly interacts with FF the HLH domain of MyoD [12], [32]; FF direct interaction with the pocket domain of Rb protein FF is required for myogenesis, maintenance of the differentiated FF state, and repression of cell proliferation [18]; FF hyperphosphorylation upon association with E47 [41]; XX IN T00131; c-Jun; mouse, Mus musculus. IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00404; Id2; mouse, Mus musculus. IN T00405; IEBP1; rat, Rattus norvegicus. IN T00432; ITF-1; human, Homo sapiens. IN T00433; ITF-2; human, Homo sapiens. IN T00505; MEF-2; mouse, Mus musculus. IN T00526; MyoD; mouse, Mus musculus. IN T00674; E47; rat, Rattus norvegicus. IN T00675; E12; rat, Rattus norvegicus. IN T01005; MEF-2; human, Homo sapiens. IN T01212; Id2; human, Homo sapiens. IN T01423; Rb; mouse, Mus musculus. IN T01454; Hsp90; mouse, Mus musculus. IN T01606; Id1.25; rat, Rattus norvegicus. IN T01769; MEF-2C; mouse, Mus musculus. IN T01770; MEF-2D; human, Homo sapiens. IN T01771; MEF-2D; clawed frog, Xenopus laevis. IN T01784; MEF-2; clawed frog, Xenopus laevis. IN T01787; E12; clawed frog, Xenopus laevis. IN T01788; E47; mouse, Mus musculus. IN T01789; SCBPgamma; rat, Rattus norvegicus. IN T01790; SCBPalpha; rat, Rattus norvegicus. IN T01791; SCBPbeta; rat, Rattus norvegicus. IN T01807; Id1; rat, Rattus norvegicus. XX MX M00001; V$MYOD_01 XX BS R03109; CHICK$ACC_03; Quality: 1; chick, Gallus gallus BS R00012; CHICK$ACRA_02; Quality: 6; chick, Gallus gallus BS R00014; CHICK$ACRA_04; Quality: 6; chick, Gallus gallus BS R02452; HS$AAC_20; Quality: 6; human, Homo sapiens BS R02418; HS$MLC_01; Quality: 6; human, Homo sapiens BS R02419; HS$MLC_02; Quality: 6; human, Homo sapiens BS R00019; MOUSE$ACRD_02; Quality: 6; mouse, Mus musculus BS R04020; MOUSE$ACRG_01; Quality: 1; mouse, Mus musculus BS R04021; MOUSE$ACRG_02; Quality: 1; mouse, Mus musculus BS R04418; MOUSE$HBEGF_01; Quality: 2; mouse, Mus musculus BS R00850; MOUSE$IGH_16; Quality: 6; mouse, Mus musculus BS R00881; MOUSE$IGKL_05; Quality: 6; mouse, Mus musculus BS R00882; MOUSE$IGKL_06; Quality: 6; mouse, Mus musculus BS R00240; MOUSE$MCK_01; Quality: 6; mouse, Mus musculus BS R00241; MOUSE$MCK_02; Quality: 6; mouse, Mus musculus BS R00242; MOUSE$MCK_03; Quality: 2; mouse, Mus musculus BS R02208; MYOD$CONS; Quality: 6 BS R02898; QUAIL$STN1_01; Quality: 2; quail, Coturnix coturnix BS R03074; RAT$MLC_01; Quality: 6; rat, Rattus norvegicus BS R03075; RAT$MLC_02; Quality: 6; rat, Rattus norvegicus BS R03076; RAT$MLC_03; Quality: 6; rat, Rattus norvegicus XX DR EMBL: X61655; MMMYOD1(g). DR EMBL: M18779; MMMYOD1A(r). DR SwissProt: P10085; MYOD_MOUSE. DR PIR: A29636; A29636. DR PIR: S22587; S22587. DR Compel: C00029 DR Compel: C00034 DR Compel: C00090 DR Compel: C00091 DR PDB: 1mdy; MYOD BASIC-HELIX-LOOP-HELIX (BHLH) DOMAIN (RESIDUES 102 - 166) MUTANT (C135S) COMPLEXED WITH DNA MOUSE. XX RN [1] RA Shaknovich R., Shue G., Kohtz D. S. RT Conformational activation of a basic helix-loop-helix RT protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84) RL Mol. Cell. Biol. 12:5059-5068 (1992). RN [2] RA Olson E.N., Spizz G., Tainsky M.A. RT The Oncogenic Forms of N-ras or H-ras Prevent Skeletal RT Myoblast Differentiation RL Mol. Cell. Biol. 7:2104-2111 (1987). RN [3] RA Lassar A. B., Paterson B. M., Weintraub H. RT Transfection of a DNA locus that mediates the conversion RT of 10T1/2 fibroblasts into myoblasts RL Cell 47:649-656 (1986). RN [4] RA Davis R. L., Weintraub H., Lassar A. B. RT Expression of a single transfected cDNA converts fibroblasts into myoblasts RL Cell 51:987-1000 (1987). RN [5] RA Sassoon D., Lyons G., Wright W. E., Lin V., Lassar RA A. B., Weintraub H., Buckingham M. RT Expression of two myogenic regulatory factors myogenin RT and MyoD1 during mouse embryogenesis RL Nature 341:303-307 (1989). RN [6] RA Lassar A. B., Thayer M. J., Overell R. W., Weintraub H. RT Transformation by activated ras or fos prevents myogenesis RT by inhibiting expression of MyoD1 RL Cell 58:659-667 (1989). RN [7] RA Weintraub H., Tapscott S. J., Davis R. L., Thayer RA M. J., Adam M. A., Lassar A. B., Miller A. D. RT Activation of muscle-specific genes in pigment, nerve, RT fat, liver, and fibroblast cell lines by forced expression of MyoD RL Proc. Natl. Acad. Sci. USA 86:5434-5438 (1989). RN [8] RA Thayer M. J., Tapscott S. J., Davis R. L., Wright RA W. E., Lassar A. B., Weintraub H. RT Positive autoregulation of the myogenic determination gene MyoD1 RL Cell 58:241-248 (1989). RN [9] RA Sorrentino V., Pepperkok R., Davis R. L., Ansorge W., Philipson L. RT Cell proliferation inhibited by MyoD1 independently RT of myogenic differentiation RL Nature 345:813-815 (1990). RN [10] RA Fuechtbauer E. M., Westphal H. RT MyoD and myogenin are coexpressed in regulating skeletal muscle of the mouse RL Devel. Dynamics 193:34-39 (1992). RN [11] RA Miner J. H., Wold B. J. RT c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation RL Mol. Cell. Biol. 11:2842-2851 (1992). RN [12] RA Li L., Chambard J. C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by RT myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [13] RA Carnac G., Albagli-Curiel O., Vandromme M., Pinset RA C., Montarras D., Laudet V., Bonnieu A. RT 3, 5, 3 - triiodothyronine positively regulates both RT MyoD1 gene transcription and terminal differentiation in C2 myoblasts RL Mol. Endocrinol. 6:1185-1194 (1992). RN [14] RA van Antwerp M. E., Chen D. G., Chang C., Prochownik E. V. RT A point mutation in MyoD basic domain imparts c-Myc-like properties RL Proc. Natl. Acad. Sci. USA 89:9010-9014 (1992). RN [15] RA Kim S. J., Kim K. Y., Tapscott S. J., Winokur T. S., RA Park K., Fujiki H., Weintraub H., Roberts A. B. RT Inhibition of protein phosphatases blocks myogenesis RT by first altering MyoD binding activity RL J. Biol. Chem. 267:15140-15145 (1992). RN [16] RA Thayer M. J., Weintraub H. RT A cellular factor stimulates the DNA-binding activity of MyoD and E47 RL Proc. Natl. Acad. Sci. USA 90:6483-6487 (1993). RN [17] RA Winter B., Braun T., Arnold H. H. RT cAMP-dependent protein kinase represses myogenic differentiation RT and the activity of the muscle-specific helix-loop-helix RT transcription factors Myf-5 and MyoD RL J. Biol. Chem. 13:9869-9878 (1993). RN [18] RA Gu W., Schneider J. W., Condorelli G., Kaushal S., RA Mahdavi V., Nadal-Ginard B. RT Interaction of myogenic factors and the retinoblastoma RT protein mediates muscle cell commitment and differentiation RL Cell 72:309-324 (1993). RN [19] RA Hollenberg S. M., Cheng P. F., Weintraub H. RT Use of a conditional MyoD transcription factor in RT studies of MyoD trans-activation and muscle determination RL Proc. Natl. Acad. Sci. USA 90:8028-8032 (1993). RN [20] RA Rudnicki M. A., Schnegelsberg P. N. J., Stead R. H., RA Braun T., Arnold H. H., Jaenisch R. RT MyoD or Myf-5 is required for the formation of skeletal muscle RL Cell 75:1351-1359 (1993). RN [21] RA Muscat G. E. O., Mynett-Johnson L., Dowhan D., Downes M., Griggs R. RT Activation of MyoD gene transcription by 3, 4, 3'-triiodo-L-thyronine: RT a direct role for the thyroid hormone and retinoid X receptors RL Nucleic Acids Res. 22:583-591 (1994). RN [22] RA Alva-Pedraza G., Zingg J. M., Jost J. P. RT AP-1 binds to a putative cAMP response element of RT the MyoD1 promoter and negatively modulates MyoD1 RT expression in dividing myoblasts RL J. Biol. Chem. 269:6978-6985 (1994). RN [23] RA Weintraub H., Genetta T., Kadesch T. RT Tissue-specific gene activation by MyoD: determination RT of specificity by cis-acting repression elements RL Genes Dev. 8:2203-2211 (1994). RN [24] RA Rudnicki M. A., Braun T., Hinuma S., Jaenisch R. RT Inactivation of MyoD in mice leads to up-regulation RT of the myogenic HLH gene Myf-5 and results in apparently RT normal muscle development RL Cell 71:383-390 (1992). RN [25] RA Ma P. C. M., Rould M. A., Weintraub H., Pabo C. O. RT Crystal structure of MyoD bHLH domain-DNA complex: RT perspectives on DNA recognition and implications for RT transcriptional activation RL Cell 77:451-459 (1994). RN [26] RA Ferre-D'Amare A. E., Prendergast G. C., Ziff E. B., Burley S. K. RT Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain RL Nature 363:38-45 (1993). RN [27] RA Ferrė-DžAmarė A. R., Pognonec P., Roeder R. G., Burley S. K. RT Structure and function of the b/HLH/Z domain of USF RL EMBO J. 13:180-189 (1993). RN [28] RA Weintraub H., Dwarki V. J., Verma I., Davis R. L., RA Hollenberg S., Snider L., Lassar A. B., Tapscott S. J. RT Muscle-specific transcriptional activation by MyoD RL Genes Dev. 5:1377-1386 (1991). RN [29] RA Fairman R., Beran-Steed R. K., Anthony-Cahill S. J., RA Lear J. D., Stafford III W. F., DeGrado W. F., Benfield P. A., Brenner S. L. RT Multiple oligomeric states regulate the DNA binding RT of helix-loop-helix proteins RL Proc. Natl. Acad. Sci. USA 90:10429-10433 (1993). RN [30] RA Shue G., Kohtz D. RT Structural and functional aspects of basic helix-loop-helix RT protein folding by heat-shock protein RL J. Biol. Chem. 269:2707-2711 (1994). RN [31] RA Crescenzi M., Fleming T. P., Lassar A. B., Weintraub H., Aaronson S. A. RT MyoD induces growth arrest independent of differentiation RT in normal and transformed cells RL Proc. Natl. Acad. Sci. USA 87:8442-8446 (1990). RN [32] RA Bengal E., Ransone L., Scharfmann R., Dwarki V. J., RA Tapscott S. J., Weintraub H., Verma I. M. RT Functional antagonism between c-Jun and MyoD proteins: RT a direct physical association RL Cell 68:507-519 (1992). RN [33] RA Lassar A. B., Buskin J. B., Lockshon D., Davis R. RA L., Apone S., Hauschka S. D., Weintraub H. RT MyoD is a sequence-specific DNA-binding protein requiring RT a region of myc homology to bind to the muscle creatine kinase enhancer RL Cell 58:823-831 (1989). RN [34] RA Murre C., McCaw P. S., Vaessin H., Caudy M., Jan L. RA Y., Jan Y. N., Cabrera C. V., Buskin J. N., Hauschka RA S. D., Lassar A. B., Weintraub H., Baltimore D. RT Interactions between heterologous helix-loop-helix RT proteins generate complexes that bind specifically to a common DNA sequence RL Cell 58:537-544 (1989). RN [35] RA Davis R. L., Cheng P.-F., Lassar A. B., Weintraub H. RT The MyoD DNA binding domain contains a recognition RT code for muscle-specific gene activation RL Cell 60:733-746 (1990). RN [36] RA Vandromme M., Cavadore J.-C., Bonnieu A., Froeschle RA A., Lamb N., Fernandez A. RT Two nuclear localization signals present in the basic-helix RT 1 domains of MyoD promote its active nuclear translocation RT and can function independly RL Proc. Natl. Acad. Sci. USA 92:4646-4650 (1995). RN [37] RA Weintraub H., Davis R., Lockshon D., Lassar A. RT MyoD binds cooperatively to two sites in a target RT enhancer sequence: Occupancy of two sites is required for activation RL Proc. Natl. Acad. Sci. USA 87:5623-5627 (1990). RN [38] RA Chakraborty T., Brennan T., Olson E. RT Differential trans-activation of a muscle-specific RT enhancer by myogenic helix-loop-helix proteins is separable from DNA binding RL J. Biol. Chem. 266:2878-2882 (1991). RN [39] RA French B. A., Chow K.-L., Olson E. N., Schwartz R. J. RT Heterodimers of myogenic helix-loop-helix regulatory RT factors and E12 bind a complex element governing myogenic RT induction of the avian cardiac alpha-actin promoter RL Mol. Cell. Biol. 11:2439-2450 (1991). RN [40] RA Sun X.-H., Baltimore D. RT An inhibitory domain of E12 transcription factor prevents RT DNA binding in E12 homodimers but not in E12 heterodimers RL Cell 64:459-470 (1991). RN [41] RA Lassar A. B., Davis R. L., Wright W. E., Kadesch T., RA Murre C., Voronova A., Baltimore D., Weintraub H. RT Functional activity of myogenic HLH proteins requires RT hetero-oligomerization with E12/E47-like proteins in vivo RL Cell 66:305-315 (1991). RN [42] RA Murre C., McCaw P. S., Baltimore D. RT A new DNA binding and dimerization motif in immunoglobulin RT enhancer binding, daughterless, MyoD, and myc proteins RL Cell 56:777-783 (1989). RN [43] RA Vaidya T. B., Rhodes S. J., Taparowsky E. J., Konieczny S. F. RT Fibroblast growth factor and transforming growth factor RT beta repress transcription of the myogenic regulatory gene MyoD1 RL Mol. Cell. Biol. 9:3576-3579 (1989). RN [44] RA Tapscott S. J., Davis R. L., Thayer M. J., Cheng P., RA Weintraub H., Lassar A. B. RT MyoD1: a nuclear phosphoprotein requiring a Myc homology RT region to convert fibroblasts to myoblasts RL Science 242:405-411 (1988). RN [45] RA Blackwell T. K., Weintraub H. RT Differences and similarities in DNA-binding preferences RT of MyoD and E2A protein complexes revealed by binding site selection RL Science 250:1104-1110 (1990). RN [46] RA Anthony-Cahill S. J., Benfield P. A., Fairman R., RA Wasserman Z. R., Brenner S. L., Stafford III W. F., RA Altenbach C., Hubbell W. L., DeGrado W. F. RT Molecular characterization of helix-loop-helix peptides RL Science 255:979-983 (1992). RN [47] RA Yutzey K. E., Rhodes S. J., Konieczny S. F. RT Differential trans activation associated with the RT muscle regulatory factors MyoD1, myogenin, and MRF4 RL Mol. Cell. Biol. 10:3934-3944 (1990). RN [48] RA Rhodes S. J., Konieczny S. F. RT Identification of MRF4: a new member of the muscle RT regulatory factor gene family RL Genes Dev. 3:2050-2061 (1989). XX // AC T00527 XX ID T00527 XX DT 26.01.93 (created); hse. DT 10.01.96 (updated); hiwi. XX FA MyoD XX SY MEF1; XX OS monkey, Cercopithecus aethiops OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; primates; haplorhini; OC catarrhini; cercopithecidae; cercopithecinae XX SZ 45 kDa (SDS) XX SF phosphorylation XX CP proliferating myoblasts and differentiated myotubes XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00404; Id2; mouse, Mus musculus. IN T00432; ITF-1; human, Homo sapiens. IN T00433; ITF-2; human, Homo sapiens. IN T00506; MEF1; mouse, Mus musculus. IN T01212; Id2; human, Homo sapiens. XX BS R02208; MYOD$CONS; Quality: 6 XX RN [1] RA Lin Z. Y., Dechesne C. A., Eldridge J., Paterson B. M. RT An avian muscle factor related to MyoD1 activates RT muscle-specific promoters in nonmuscle cells of different RT germ-layer origin and in BrdU-treated myoblasts RL Genes Dev. 3:986-996 (1989). RN [2] RA Davis R. L., Cheng P.-F., Lassar A. B., Weintraub H. RT The MyoD DNA binding domain contains a recognition RT code for muscle-specific gene activation RL Cell 60:733-746 (1990). RN [3] RA Murre C., McCaw P. S., Baltimore D. RT A new DNA binding and dimerization motif in immunoglobulin RT enhancer binding, daughterless, MyoD, and myc proteins RL Cell 56:777-783 (1989). RN [4] RA Vaidya T. B., Rhodes S. J., Taparowsky E. J., Konieczny S. F. RT Fibroblast growth factor and transforming growth factor RT beta repress transcription of the myogenic regulatory gene MyoD1 RL Mol. Cell. Biol. 9:3576-3579 (1989). RN [5] RA Tapscott S. J., Davis R. L., Thayer M. J., Cheng P., RA Weintraub H., Lassar A. B. RT MyoD1: a nuclear phosphoprotein requiring a Myc homology RT region to convert fibroblasts to myoblasts RL Science 242:405-411 (1988). XX // AC T00528 XX ID T00528 XX DT 21.10.92 (created); ewi. DT 14.02.97 (updated); ewi. XX FA myogenin XX SY Myf-4 (human); MyoG; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; 1.2.2.0.2. XX SZ 224 AA; 25.2 kDa (cDNA) XX SQ MELYETSPYFYQEPHFYDGENYLPVHLQGFEPPGYERTELSLSPEARGPLEEKGLGTPEH SQ CPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVE SQ ILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPMVPSECNSHSASCSPEWGNALEFG SQ PNPGDHLLAADPTDAHNLHSLTSIVDSITVEDMSVAFPDETMPN XX SC SwissProt #P12979 XX FT 1 81 N-terminal transcription activating domain (N-TAD) FT 82 93 basic region FT 94 133 helix-loop-helix domain FT 132 146 putative leucine repeat (L3) FT 156 224 C-terminal transcription activating domain (C-TAD) FT 156 198 C-TAD subdomain 1 FT 203 224 C-TAD subdomain 2 XX SF at high concentrations: homodimeric DNA-binding SF at low concentrations, myogenin has to heterodimerize for DNA-binding [22]; SF important for muscle-specific trans-activation and SF differentiation: A86, T87 [31]; SF N- and C-terminal regions have to cooperate for full SF transcriptioal activation [24]; XX CP myogenic cells; skeletal muscle cells XX FF muscle-specific transcription activator; FF may have to cooperate with other transcription factors FF (NF-1, MEF-2, COMP1) [1]; FF may have specific function for muscle formation in FF some regions of the embryo, particularly in the latero-ventral body wall ; FF disruption of its gene cannot be compensated by other myogenic factors [17]; FF myogenin is expressed after Myf-5, before MRF4 [4], [11]; FF expressed in regenerating skeletal muscle for at least 2 weeks [7]; FF developing limb bud: coexpression with MyoD [4]; FF myogenin constitutes a positive autoregulatory loop with MEF-2 [28], [14]; FF innervation of muscle tissue causes down-regulation, FF denervation leads to reactivation of myogenin expression [18]; FF for onset of myogenin, an ill-defined dephosphorylation FF step is required [10]; FF PKC-phosphorylation (S77), e. g. as triggered by FGF, FF inhibits DNA-binding [23]; FF in heterodimers, myogenin can be phosphorylated at S43, S170, S199, S224; FF modification of S43/S170 reduced the trans-activation potential [21]; FF cyclin D1 inhibits Myf-4 activity through its C-terminal region [19]; XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00505; MEF-2; mouse, Mus musculus. IN T00528; myogenin; mouse, Mus musculus. IN T00675; E12; rat, Rattus norvegicus. IN T01005; MEF-2; human, Homo sapiens. IN T01503; HEB; human, Homo sapiens. IN T01784; MEF-2; clawed frog, Xenopus laevis. IN T01787; E12; clawed frog, Xenopus laevis. XX BS R03109; CHICK$ACC_03; Quality: 1; chick, Gallus gallus BS R04409; CHICK$MYOGN_01; Quality: 5; chick, Gallus gallus BS R00018; MOUSE$ACRD_01; Quality: 6; mouse, Mus musculus BS R00850; MOUSE$IGH_16; Quality: 2; mouse, Mus musculus BS R04158; MOUSE$IGH_59; Quality: 2; mouse, Mus musculus BS R00242; MOUSE$MCK_03; Quality: 2; mouse, Mus musculus BS R02898; QUAIL$STN1_01; Quality: 6; quail, Coturnix coturnix BS R03074; RAT$MLC_01; Quality: 2; rat, Rattus norvegicus BS R03075; RAT$MLC_02; Quality: 2; rat, Rattus norvegicus XX DR EMBL: X71910; MMMYGNPRO(g). DR EMBL: D90156; MMMYO(r). DR EMBL: X15784; MMMYOG(r). DR EMBL: M95800; MMMYOGEN(g). DR SwissProt: P12979; MYOG_MOUSE. DR PIR: A36675; A36675. DR PIR: A45008; A45008. XX RN [1] RA Funk W. D., Wright W. E. RT Cyclic amplification and selection of targets for RT multicomponent complexes: Myogenin interacts with RT factors recognizing binding sites for basic helix--loop--helix, RT nuclear factor 1, myocyte-specific enhancer-binding RT factor 2 , and COMP1 factor RL Proc. Natl. Acad. Sci. USA 89:9484-9488 (1992). RN [2] RA Hu J.-S., Olson E. N., Kingston R. E. RT HEB, a helix-loop-helix protein related to E2A and RT ITF2 that can modulate the DNA-binding ability of RT myogenic regulatory factors RL Mol. Cell. Biol. 12:1031-1042 (1992). RN [3] RA Fujisawa-Sehara A., Nabeshima Y., Hosoda Y., Obinata T., Nabeshima Y.-I. RT Myogenic Contains Two Domains Conserved among Myogenic Factors RL J. Biol. Chem. 265:15219-15223 (1990). RN [4] RA Sassoon D., Lyons G., Wright W. E., Lin V., Lassar RA A. B., Weintraub H., Buckingham M. RT Expression of two myogenic regulatory factors myogenin RT and MyoD1 during mouse embryogenesis RL Nature 341:303-307 (1989). RN [5] RA Lassar A. B., Thayer M. J., Overell R. W., Weintraub H. RT Transformation by activated ras or fos prevents myogenesis RT by inhibiting expression of MyoD1 RL Cell 58:659-667 (1989). RN [6] RA Thayer M. J., Tapscott S. J., Davis R. L., Wright RA W. E., Lassar A. B., Weintraub H. RT Positive autoregulation of the myogenic determination gene MyoD1 RL Cell 58:241-248 (1989). RN [7] RA Fuechtbauer E. M., Westphal H. RT MyoD and myogenin are coexpressed in regulating skeletal muscle of the mouse RL Devel. Dynamics 193:34-39 (1992). RN [8] RA Miner J. H., Wold B. J. RT c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation RL Mol. Cell. Biol. 11:2842-2851 (1992). RN [9] RA Li L., Chambard J. C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by RT myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [10] RA Kim S. J., Kim K. Y., Tapscott S. J., Winokur T. S., RA Park K., Fujiki H., Weintraub H., Roberts A. B. RT Inhibition of protein phosphatases blocks myogenesis RT by first altering MyoD binding activity RL J. Biol. Chem. 267:15140-15145 (1992). RN [11] RA Rudnicki M. A., Braun T., Hinuma S., Jaenisch R. RT Inactivation of MyoD in mice leads to up-regulation RT of the myogenic HLH gene Myf-5 and results in apparently RT normal muscle development RL Cell 71:383-390 (1992). RN [12] RA Li L., Heller-Harrison R., Czech M., Olson E. N. RT Cyclic AMP-dependent protein kinase inhibits the activity RT of myogenic helix-loop-helix proteins RL Mol. Cell. Biol. 12:4478-4485 (1992). RN [13] RA Brunetti A., Goldfine I. D. RT Role of myogenin in myoblast differentiation and its RT regulation by fibroblast growth factor RL J. Biol. Chem. 265:5960-5963 (1990). RN [14] RA Edmondson D. G., Cheng T. C., Cserjesi P., Chakraborty T., Olson E. N. RT Analysis of the myogenin promoter eveals an indirect RT pathway for positive autoregulation mediated by the RT muscle-specific enhancer factor MEF-2 RL Mol. Cell. Biol. 12:3665-3677 (1992). RN [15] RA Yee S.-P., Rigby P. W. J. RT The regulation of myogenin gene expression during RT the embryonic development of the mouse RL Genes Dev. 7:1277-1289 (1993). RN [16] RA Cheng T. C., Wallace M. C., Merlie J. P., Olson E. N. RT Separable regulatory elements governing myogenin transcription RT in mouse embryogenesis RL Science 261:215-218 (1993). RN [17] RA Nabeshima Y., Hanaoka K., Hayasaka M., Esumi E., Li RA S., Nonaka I., Nabeshima Y. I. RT Myogenin gene disruption results in perinatal lethality RT because of severe muscle defect RL Nature 364:532- (1993). RN [18] RA Buonanno A., Edmondson D. G., Hayes W. P. RT Upstream sequences of the myogenin gene convey responsiveness RT to skeletal muscle denervation on transgenic mice RL Nucleic Acids Res. 21:5684-5693 (1993). RN [19] RA Rao S. S., Chu C., Kohtz D. S. RT Ectopic expression of cyclin D1 prevents activation RT of gene transcription by myogenic basic helix-loop-helix regulators RL Mol. Cell. Biol. 14:5259-5267 (1994). RN [20] RA Sanchez A., Robbins J. RT Unprocessed myogenin transcripts accumulate during mouse embryogenesis RL J. Biol. Chem. 269:1587-1590 (1994). RN [21] RA Zhou J., Olson E. N. RT Dimerization through the helix-loop-helix motif enhances RT phosphorylation of the transcription activation domain RL Mol. Cell. Biol. 14:6232-6243 (1994). RN [22] RA Chakraborty T., Martin J. F., Olson E. N. RT Analysis of the oligomerization of myogenin and E2A RT products in vivo using a two-hybrid assay system RL J. Biol. Chem. 267:17498-17501 (1992). RN [23] RA Li L., Zhou J., James G., Heller-Harrison R., Czech M. P., Olson E. N. RT FGF inactivates myogenic helix-loop-helix proteins RT through phosphorylation of a conserved protein kinase RT C site in their DNA-binding domains RL Cell 71:1181-1194 (1992). RN [24] RA Schwarz J. J., Chakraborty T., Martin J., Zhou J., Olson E. N. RT The basic region of myogenin cooperates with two transcription RT activation domains to induce muscle-specific transcription RL Mol. Cell. Biol. 12:266-275 (1992). RN [25] RA Toledano M. B., Leonard W. J. RT Modulation of transcription factor NF-kappaB binding RT activity by oxidation-reduction in vitro RL Proc. Natl. Acad. Sci. USA 88:4328-4332 (1991). RN [26] RA Chakraborty T., Brennan T. J., Li L., Edmondson D., Olson E. N. RT Inefficient homooligomerization contributes to the RT dependence of myogenin on E2A products for efficient DNA binding RL Mol. Cell. Biol. 11:3633-3641 (1991). RN [27] RA Edmondson D. G., Olson E. N. RT A gene with homology to the myc similarity region RT of MyoD1 is expressed during myogenesis and is sufficient RT to activate the muscle differentiation program RL Genes Dev. 3:628-640 (1989). RN [28] RA Cserjesi P., Olson E. N. RT Myogenin induces the myocyte-specific enhancer binding RT factor MEF-2 independently of other muscle-specific gene products RL Mol. Cell. Biol. 11:4854-4862 (1991). RN [29] RA Chakraborty T., Olson E. N. RT Domains outside of the DNA-binding domain impart target RT gene specificity to myogenin and MRF4 RL Mol. Cell. Biol. 11:6103-6108 (1991). RN [30] RA Yutzey K. E., Rhodes S. J., Konieczny S. F. RT Differential trans activation associated with the RT muscle regulatory factors MyoD1, myogenin, and MRF4 RL Mol. Cell. Biol. 10:3934-3944 (1990). RN [31] RA Brennan T. J., Chakraborty T., Olson E. N. RT Mutagenesis of the myogenin basic region identifies RT an ancient protein motif critical for activation of myogenesis RL Proc. Natl. Acad. Sci. USA 88:5675-5679 (1991). RN [32] RA Brennan T. J., Edmondson D. G., Li L., Olson E. N. RT Transforming growth factor beta represses the actions RT of myogenin through a mechanism independent of DNA binding RL Proc. Natl. Acad. Sci. USA 88:3822-3826 (1991). RN [33] RA Rhodes S. J., Konieczny S. F. RT Identification of MRF4: a new member of the muscle RT regulatory factor gene family RL Genes Dev. 3:2050-2061 (1989). XX // AC T00529 XX ID T00529 XX DT 10.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA MZF-1 XX SY MZF1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; 2.3.2.2.10. XX SZ 485 AA XX SQ MNGPLVYAGFALQLGSISAGPGSVSPHLHVPWDLGMAGLSGQIQSPSREGGFAHRVLLPS SQ DLRSEQDPTDEDPCRGVGPALITTRWRSPRGRSRGRPSTGGGVVRGGRCDVCGKVFSQRS SQ NLLRHQKIHTGERPFVCSECGRSFSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEE SQ HRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGDPPGPGAKPPAPPGAPEPPGPFPCSE SQ CRESFARRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSGERPFACAECGQS SQ FRQRSNLTQHRRIHTGERPFACAECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRFSQR SQ LKLTRHQRTHTGEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLT SQ QHRRIHTGERPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQSTKLIQHQR SQ VHSAE XX SC SwissProt #P28698 XX SF 4+9 zinc finger motifs SF glycine-rich region, phosphorylation XX CP myeloid cells XX FF responsive to retinoic acid; FF possibly involved in hemopoietic development; FF both zinc finger domains bind to similar DNA motifs, FF the full-length protein to either of these sequences [1]; XX MX M00083; V$MZF1_01 XX DR EMBL: M58297; HSMZF1(r). DR SwissProt: P28698; ZN42_HUMAN. DR PIR: A40751; A40751. XX RN [1] RA Morris J. F., Hromas R., Rauscher III F. J. RT Characterization of the DNA-binding properties of RT the myeloid zinc finger protein MZF1: two independent RT DNA-binding domains recognize two DNA consensus sequences RT with a common G-rich core RL Mol. Cell. Biol. 14:1786-1795 (1994). RN [2] RA Hromas R., Collins S. J., Hickstein D., Raskind W., RA Deaven L. L., O'Hara P., Hagen F. S., Kaushansky K. RT A retinoic acid-responsive human zinc finger gene, RT MZF-1, preferentially expressed in myeloid cells RL J. Biol. Chem. 266:14183-14187 (1991). XX // AC T00530 XX ID T00530 XX DT 16.04.93 (created); ewi. DT 23.05.97 (updated); hiwi. XX FA NC1 XX SY DBF1; negative cofactor 1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF TBP cofactor XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX BS R00705; HIV1$HIV1_12; Quality: 6; HIV-1, human immunodeficiency virus type 1 XX RN [1] RA Meisterernst M., Roy A. L., Lieu H. M., Roeder R. G. RT Activation of class II gene transcription by regulatory RT factors is potentiated by a novel activity RL Cell 66:981-993 (1991). RN [2] RA Meisterernst M., Roeder R. G. RT Family of proteins that interact with TFIID and regulate promoter activity RL Cell 67:557-567 (1991). XX // AC T00531 XX ID T00531 XX DT 16.04.93 (created); ewi. DT 23.05.97 (updated); hiwi. XX FA NC2 XX SY DBF2; Dr1; negative cofactor 2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 176 AA; 19.3 kDa (cDNA), 19 kDa (SDS) XX SQ MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNK SQ SEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLR SQ QQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI XX SC SwissProt #Q01658 XX FT 130 150 glutamine-/alanine-rich region (14/21) XX FF TBP cofactor, competes with TFIIA for binding to TBP FF and supresses core promoter activity (e.g., HIV-1 promoter) XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX BS R00705; HIV1$HIV1_12; Quality: 6; HIV-1, human immunodeficiency virus type 1 XX DR EMBL: M97388; HSDR1TATA(empty). DR SwissProt: Q01658; TBAP_HUMAN. DR PIR: A43320; A43320. XX RN [1] RA Kim T. K., Zhao Y., Ge H., Bernstein R., Roeder R. G. RT TATA-binding protein residues implicated in a functional RT interplay between negative cofactor NC2(Dr1) and general RT factors TFIIA and TFIIB RL J. Biol. Chem. 270:10976-10981 (1995). RN [2] RA White R. J., Khop B. C.-E., Inostroza J. A., Reinberg D., Jackson S. P. RT Differential regulation of RNA Polymerase I, II and RT III by the TBP-binding repressor Dr1 RL Science 266:448-450 (1994). RN [3] RA Kraus V. B., Inostroza J. A., Yeung K., Reinberg D., Nevins J. R. RT Interaction of the Dr1 inhibitory factor with the RT TATA binding protein is disrupted by adenovirus E1A RL Proc. Natl. Acad. Sci. USA 91:6279-6282 (1994). RN [4] RA Inostroza J. A., Mermelstein F. H., Ha I., Lane W. S., Reinberg D. RT Dr1, a TATA-binding protein-associated phosphoprotein RT and inhibitor of class II gene transcription RL Cell 70:477-489 (1992). RN [5] RA Meisterernst M., Roeder R. G. RT Family of proteins that interact with TFIID and regulate promoter activity RL Cell 67:557-567 (1991). XX // AC T00532 XX ID T00532 XX DT 15.10.92 (created); ewi. XX FA NeP1 XX SY negative protein 1; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX SZ 75-93 kDa (SDS) XX BS R01672; CHICK$LYS_14; Quality: 1; chick, Gallus gallus XX RN [1] RA Baniahmad A., Steiner C., Koehne A. C., Renkawitz R. RT Modular structure of a chicken lysozyme silencer: RT involvement of an unusual thyroid hormone receptor binding site RL Cell 61:505-514 (1990). XX // AC T00533 XX ID T00533 XX DT 15.10.92 (created); ewi. XX FA NF-1 XX SY NF-I; XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX MX M00056; V$MYOGNF1_01 XX BS R01658; FELV$FELV_03; Quality: 6; FeLV, feline leukemia virus BS R02209; NF1$CONS; Quality: 6 XX RN [1] RA Fulton R., Plumb M., Shield L., Neil J. C. RT Structural Diversity and Nuclear Protein Binding Sites RT in the Long Terminal Repeats of Feline Leukemia Virus RL J. Virol. 64:1675-1682 (1990). XX // AC T00534 XX ID T00534 XX DT 15.10.92 (created); ewi. XX FA NF-1 XX SY CTF; NF-I; XX OS monkey, Cercopithecus aethiops OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; primates; haplorhini; OC catarrhini; cercopithecidae; cercopithecinae XX MX M00056; V$MYOGNF1_01 XX BS R00167; BKV$BKV_01; Quality: 6; BKV, human polyomavirus BK BS R00169; BKV$BKV_03; Quality: 6; BKV, human polyomavirus BK BS R00594; HS$GHA_06; Quality: 6; human, Homo sapiens BS R02209; NF1$CONS; Quality: 6 BS R01212; RAT$PEPCK_01; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Quinn P. G., Wong T. W., Magnuson M. A., Shabb J. B., Granner D. K. RT Identification of Basal and Cyclic AMP Regulatory RT Elements in the Promoter of the Phosphoenolpyruvate Carboxykinase Gene RL Mol. Cell. Biol. 8:3467-3475 (1988). RN [2] RA Grinnell B. W., Berg D. T., Walls J. D. RT Negative Regulation of the Human Polyomavirus BK Enhancer RT Involves Cell-Specific Interaction with a Nuclear Repressor RL Mol. Cell. Biol. 8:3448-3457 (1988). XX // AC T00535 XX ID T00535 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA NF-1 XX SY CTF; NF-I; TGGCA-binding protein (chick); XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 52-66 kDa (SDS) XX SQ LCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEK SQ PEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQAD SQ KVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVH SQ AADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNF SQ SLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSG SQ SQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHAT SQ PSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQ SQ GKVHNPFLPTPMLPPPPPPPMARPVPLPMPDTKPPTTSTEGGAASPTSPTYSTPSTSPAN SQ RFVSVGPRDPSFVNIPQQTQSWYLG XX SC SwissProt #P09414 XX SF O-glycosylation XX IN T00535; NF-1; rat, Rattus norvegicus. XX MX M00056; V$MYOGNF1_01 XX BS R00313; AD$E1A_07; Quality: 6; adenovirus type 12 BS R01175; AD$ORI_01; Quality: 6; adenovirus type 2 BS R03066; AS$NF1_01; Quality: 6 BS R00633; HBV$HBVE_04; Quality: 6; HBV, human hepatitis B virus BS R00607; HS$GRH_01; Quality: 6; human, Homo sapiens BS R01455; HS$TF_06; Quality: 6; human, Homo sapiens BS R00229; MOUSE$A21COL_01; Quality: 6; mouse, Mus musculus BS R00085; MOUSE$ALBU_04; Quality: 6; mouse, Mus musculus BS R00088; MOUSE$ALBU_07; Quality: 6; mouse, Mus musculus BS R01162; MOUSE$MBP_01; Quality: 6; mouse, Mus musculus BS R02209; NF1$CONS; Quality: 6 BS R01624; RAT$A1I3_02; Quality: 6; rat, Rattus norvegicus BS R00431; RAT$AFEP_08; Quality: 6; rat, Rattus rattus BS R01698; RAT$AFEP_11; Quality: 6; rat, Rattus norvegicus BS R00095; RAT$ALBU_19; Quality: 6; rat, Rattus norvegicus BS R03309; RAT$ARGL_03; Quality: 6; rat, Rattus norvegicus BS R01213; RAT$PEPCK_02; Quality: 6; rat, Rattus norvegicus BS R02990; RAT$PFK_06; Quality: 6; rat, Rattus norvegicus XX DR EMBL: X13167; RNNF1L(r). DR SwissProt: P09414; NFIL_RAT. DR PIR: S01300; S01300. XX RN [1] RA Mermod N., Williams T. J., Tjian R. RT Enhancer binding factors AP-4 and AP-1 act in concert RT to activate SV40 late transcription in vitro RL Nature 332:557-561 (1988). RN [2] RA Cato A. C. B., Skroch P., Weinmann J., Butkeraitis P., Ponta H. RT DNA sequences outside the receptor-binding sites differentially RT modulate the responsiveness of the mouse mammary tumor RT virus to various steroid hormones RL EMBO J. 7:1403-1410 (1988). RN [3] RA Lichtsteiner S., Wuarin J., Schibler U. RT The Interplay of DNA-Binding Proteins on the Promoter RT of the Mouse Albumin Gene RL Cell 51:963-973 (1987). RN [4] RA Paonessa G., Gounari F., Frank R., Cortese R. RT Purification of a NF1-like DNA-binding protein from RT rat liver and cloning of the corresponding cDNA RL EMBO J. 7:3115-3123 (1988). RN [5] RA Herbst R. S., Friedman N., Darnell J. E., Babiss L. E. RT Positive and negative regulatory elements in the mouse albumin enhancer RL Proc. Natl. Acad. Sci. USA 86:1553-1557 (1989). RN [6] RA Cereghini S., Raymondjean M., Garcia Carranca A., Herbomel P., Yaniv M. RT Factors Involved in Control of Tissue-Specific Expression of Albumin Gene RL Cell 50:627-638 (1987). RN [7] RA Rossi P., Karsenty G., Roberts A. B., Roche N. S., RA Sporn M. B., de Crombrugghe B. RT A Nuclear Factor I Binding Site Mediates the Transcriptional RT Activation of a Type I Collagen Promoter by Transforming Growth Factor-beta RL Cell 52:405-414 (1988). RN [8] RA Abraham L. J., Bradshaw A. D., Shiels B. R., Northemann RA W., Hudson G., Fey G. H. RT Hepatic Transcription of the Acute-Phase alpha1-Inhibitor RT III Gene Is Controlled by a Novel Combination of cis-Acting RT Regulatory Elements RL Mol. Cell. Biol. 10:3483-3491 (1990). RN [9] RA Dikstein R., Faktor O., Ben-Levy R., Shaul Y. RT Functional Organization of the Hepatitis B Virus Enhancer RL Mol. Cell. Biol. 10:3683-3689 (1990). RN [10] RA Jose-Estanyol M., Danan J.-L. RT A Liver-Specific Factor and Nuclear Factor I Bind RT to the Rat alpha-Fetoprotein Promoter RL J. Biol. Chem. 263:10865-10871 (1988). RN [11] RA Bokar J. A., Roesler W. J., Vandenbark G. R., Kaetzel RA D. M., Hanson R. W., Nilson J. H. RT Characterization of the cAMP Responsive Elements from RT the Genes for the alpha-Subunit of Glycoprotein Hormones RT and Phosphoenolpyruvate Carboxykinase (GTP) RL J. Biol. Chem. 263:19740-19747 (1988). RN [12] RA Courtois S. J., Lafontaine D. A., Lemaigre F. P., RA Durviaux S. M., Rousseau G. G. RT Nuclear factor-I and activator protein-2 bind in a RT mutually exclusive way to overlapping promoter sequences RT and trans-activate the human growth hormone gene RL Nucleic Acids Res. 18:57-64 (1990). RN [13] RA Trujillo M. A., Letovsky J., Maguire H. F., Lopez-Cabrera M., Siddiqui A. RT Functional analysis of a liver-specific enhancer of the hepatitis B virus RL Proc. Natl. Acad. Sci. USA 88:3797-3801 (1991). RN [14] RA Takiguchi M., Mori M. RT In vitro analysis of the rat liver-type arginase promoter RL J. Biol. Chem. 266:9186-9193 (1991). RN [15] RA Mul Y. M., Verrijzer C. P., van der Vliet P. C. RT Transcription factors NFI and NFIII/oct-1 function RT independently, employing different mechanisms to enhance RT adenovirus DNA replication RL J. Virol. 64:5510-5518 (1990). RN [16] RA Goyal N., Knox J., Gronostajski R. M. RT Analysis of multiple forms of nuclear factor I in RT human and murine cell lines RL Mol. Cell. Biol. 10:1041-1048 (1990). RN [17] RA Gounari F., De Francesco R., Schmitt J., van der Vliet RA P., Cortese R., Stunnenberg H. RT Amino-terminal domain of NF1 binds to DNA as a dimer RT and activates adenovirus DNA replication RL EMBO J. 9:559-566 (1990). XX // AC T00536 XX ID T00536 XX DT 15.10.92 (created); ewi. XX FA NF-1 XX SY CTF; NF-I; XX OS clawed frog, Xenopus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CP (oocytes) XX MX M00056; V$MYOGNF1_01 XX BS R00340; AD$E3_02; Quality: 6; adenovirus type 2 BS R01443; HSV1$TK_02; Quality: 6; HSV-1, herpes simplex virus type 1 BS R02209; NF1$CONS; Quality: 6 BS R01588; XENLA$VITB1_02; Quality: 6; clawed frog, Xenopus laevis BS R01589; XENLA$VITB1_03; Quality: 6; clawed frog, Xenopus laevis XX RN [1] RA Richter J. D. RT In vivo photocrosslinking reveals that transcription RT factor binding to the mammalian ATF recognition sequence RT is required for E1A-induced transactivation in injected RT Xenopus laevis oocytes RL Nucleic Acids Res. 17:4503-4516 (1989). XX // AC T00537 XX ID T00537 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA NF-1 XX SY CTF; NF-I; TGGCA-binding protein; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 52-66 kDa (SDS) XX SF O-glycosylation XX IN T00537; NF-1; mouse, Mus musculus. XX MX M00056; V$MYOGNF1_01 XX BS R01752; HS$AAC_09; Quality: 6; human, Homo sapiens BS R01125; MMTV$MMTV_27; Quality: 6; MMTV, mouse mammary tumor virus BS R01126; MMTV$MMTV_28; Quality: 6; MMTV, mouse mammary tumor virus BS R01127; MMTV$MMTV_29; Quality: 6; MMTV, mouse mammary tumor virus BS R03111; MMTV$MMTV_39; Quality: 6; MMTV, mouse mammary tumor virus BS R04187; MMTV$MMTV_43; Quality: 4; MMTV, mouse mammary tumor virus BS R01136; MOMLV$MOMULV_03; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R01137; MOMLV$MOMULV_04; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R01144; MOMLV$MOMULV_11; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R01145; MOMLV$MOMULV_12; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R02873; MOUSE$A11COL_04; Quality: 6; mouse, Mus musculus BS R03336; MOUSE$A11COL_07; Quality: 6; mouse, Mus musculus BS R00229; MOUSE$A21COL_01; Quality: 6; mouse, Mus musculus BS R02045; MOUSE$AFEP_14; Quality: 6; mouse, Mus musculus BS R03106; MOUSE$AP2_07; Quality: 6; mouse, Mus musculus BS R03434; MOUSE$BMG_08; Quality: 6; mouse, Mus musculus BS R02864; MOUSE$GFAP_02; Quality: 6; mouse, Mus musculus BS R01162; MOUSE$MBP_01; Quality: 6; mouse, Mus musculus BS R01681; MOUSE$NCAM_08; Quality: 6; mouse, Mus musculus BS R04395; MOUSE$P53_04; Quality: 6; mouse, Mus musculus BS R03127; MOUSE$TPA_02; Quality: 6; mouse, Mus musculus BS R02209; NF1$CONS; Quality: 6 BS R01245; PA$PYNB11_01; Quality: 6; Py, polyoma virus BS R01246; PA$PYNB11_02; Quality: 6; Py, polyoma virus BS R01357; SL3$SL3_01; Quality: 6; SL3-3 virus XX DR Compel: C00002 DR Compel: C00064 XX RN [1] RA Mermod N., Williams T. J., Tjian R. RT Enhancer binding factors AP-4 and AP-1 act in concert RT to activate SV40 late transcription in vitro RL Nature 332:557-561 (1988). RN [2] RA Nowock J., Borgmeyer U., Pueschel A. W., Rupp R. A. W., Sippel A. E. RT The TGGCA protein binds to the MMTV-LTR, the adenovirus RT origin of replication, and the BK virus enhancer RL Nucleic Acids Res. 13:2045-2061 (1985). RN [3] RA Buetti E., Kuehnel B., Diggelmann H. RT Dual function of a nuclear factor I binding site in RT MMTV transcription regulation RL Nucleic Acids Res. 17:3065-3078 (1989). RN [4] RA Speck N. A., Baltimore D. RT Six distinct nuclear factors interact with the 75-base-pair RT repeat of the moloney murine leukemia virus enhancer RL Mol. Cell. Biol. 7:1101-1110 (1987). RN [5] RA Kryszke M.-H., Piette J., Yaniv M. RT Induction of a factor that binds to the polyoma virus RT A enhancer on differentiation of embryonal carcinoma cells RL Nature 328:254-256 (1987). RN [6] RA Hatamochi A., Paterson B., de Crombrugghe B. RT Differential binding of a CCAAT DNA binding factor RT to the promoters of the mouse alpha2(I) and alpha1(III) collagen genes RL J. Biol. Chem. 261:11310-11314 (1986). RN [7] RA Oikarinen J., Hatamochi A., de Crombrugghe B. RT Separate Binding Sites for Nuclear Factor 1 and a RT CCAAT DNA Binding Factor in the Mouse alpha2(I) Collagen Promoter RL J. Biol. Chem. 262:11064-11070 (1987). RN [8] RA Rossi P., Karsenty G., Roberts A. B., Roche N. S., RA Sporn M. B., de Crombrugghe B. RT A Nuclear Factor I Binding Site Mediates the Transcriptional RT Activation of a Type I Collagen Promoter by Transforming Growth Factor-beta RL Cell 52:405-414 (1988). RN [9] RA Hirsch M.-R., Gaugler L., Deagostini-Bazin H., Bally-Cuif L., Goridis C. RT Identification of Positive and Negative Regulatory RT Elements Governing Cell-Type-Specific Expression of RT the Neural Cell Adhesion Molecule Gene RL Mol. Cell. Biol. 10:1959-1968 (1990). RN [10] RA Courtois S. J., Lafontaine D. A., Lemaigre F. P., RA Durviaux S. M., Rousseau G. G. RT Nuclear factor-I and activator protein-2 bind in a RT mutually exclusive way to overlapping promoter sequences RT and trans-activate the human growth hormone gene RL Nucleic Acids Res. 18:57-64 (1990). RN [11] RA Graves R. A., Tontonoz P., Ross S. R., Spiegelman B. M. RT Identification of a potent adipocyte-specific enhancer: RT involvement of an NF-1-like factor RL Genes Dev. 5:428-437 (1991). RN [12] RA Mul Y. M., Verrijzer C. P., van der Vliet P. C. RT Transcription factors NFI and NFIII/oct-1 function RT independently, employing different mechanisms to enhance RT adenovirus DNA replication RL J. Virol. 64:5510-5518 (1990). RN [13] RA Goyal N., Knox J., Gronostajski R. M. RT Analysis of multiple forms of nuclear factor I in RT human and murine cell lines RL Mol. Cell. Biol. 10:1041-1048 (1990). RN [14] RA Gounari F., De Francesco R., Schmitt J., van der Vliet RA P., Cortese R., Stunnenberg H. RT Amino-terminal domain of NF1 binds to DNA as a dimer RT and activates adenovirus DNA replication RL EMBO J. 9:559-566 (1990). XX // AC T00538 XX ID T00538 XX DT 15.10.92 (created); ewi. DT 14.03.95 (updated); hiwi. XX FA NF-1 XX SY CTF; NF-I; TGGCA-binding protein; XX OS domestic pig, Sus scrofa OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; artiodactyla; suiformes; suidae XX SZ 36 kDa (SDS) XX MX M00056; V$MYOGNF1_01 XX BS R01175; AD$ORI_01; Quality: 6; adenovirus type 2 BS R01126; MMTV$MMTV_28; Quality: 6; MMTV, mouse mammary tumor virus BS R02209; NF1$CONS; Quality: 6 BS R01543; PIG$UPA_12; Quality: 6; domestic pig, Sus scrofa XX DR EMBL: X12764; SSNF1A(g). DR SwissProt: P14057; NFIL_PIG. DR SwissProt: P21999; NFIM_PIG. DR PIR: A33416; A33416. DR PIR: JT0463; JT0463. XX RN [1] RA Brueggemeier U., Rogge L., Winnacker E.-L., Beato M. RT Nuclear factor I acts as a transcription factor on RT the MMTV promoter but competes with steroid hormone RT receptors for DNA binding RL EMBO J. 9:2233-2239 (1990). RN [2] RA Gloss B., Yeo-Gloss M., Meisterernst M., Rogge L., RA Winnacker E. L., Bernard H.-U. RT Clusters of nuclear factor I binding sites identify RT enhancers of several papillomaviruses but lone are RT not sufficient for enhancer function RL Nucleic Acids Res. 17:3519-3533 (1989). RN [3] RA Meisterernst M., Gander I., Rogge L., Winnacker E.-L. RT A quantitative analysis of a nuclear factor 1/DNA interaction RL Nucleic Acids Res. 16:4419-4435 (1988). XX // AC T00539 XX ID T00539 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA NF-1 XX SY CTF; NF-I; TGGCA-binding protein; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 55, 160, 47 kDa XX SQ MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVK SQ QKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWR SQ LDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA SQ EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSL SQ GELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSS SQ SRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHP SQ SSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQ SQ LKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFV SQ GLGPRDPAGIYQAQSWYLG XX SC SwissProt #P08651 XX SF O-glycosylation XX MX M00056; V$MYOGNF1_01 XX BS R00312; AD$E1A_06; Quality: 6; adenovirus type 12 BS R01988; AD$E1A_12; Quality: 6; adenovirus type 5 BS R00347; AD$E4_01; Quality: 6; adenovirus BS R01175; AD$ORI_01; Quality: 6; adenovirus type 2 BS R00167; BKV$BKV_01; Quality: 6; BKV, human polyomavirus BK BS R00169; BKV$BKV_03; Quality: 6; BKV, human polyomavirus BK BS R01774; BKV$BKV_08; Quality: 6; BKV, human polyomavirus BK BS R00633; HBV$HBVE_04; Quality: 6; HBV, human hepatitis B virus BS R00636; HBV$HBVE_07; Quality: 6; HBV, human hepatitis B virus BS R00640; HBV$HBVE_11; Quality: 6; HBV, human hepatitis B virus BS R01367; HBV$SA_01; Quality: 6; HBV, human hepatitis B virus BS R00802; HCMC$IE1_16; Quality: 6; hCMV, human cytomegalovirus BS R00789; HCMV$IE1_03; Quality: 6; hCMV, human cytomegalovirus BS R00790; HCMV$IE1_04; Quality: 6; hCMV, human cytomegalovirus BS R00791; HCMV$IE1_05; Quality: 6; hCMV, human cytomegalovirus BS R00792; HCMV$IE1_06; Quality: 6; hCMV, human cytomegalovirus BS R00799; HCMV$IE1_13; Quality: 6; hCMV, human cytomegalovirus BS R00803; HCMV$IE1_17; Quality: 6; hCMV, human cytomegalovirus BS R00809; HCMV$IE1_23; Quality: 6; hCMV, human cytomegalovirus BS R00729; HPV$HPV11_01; Quality: 6; HPV-11, human papilloma virus type 11 BS R00730; HPV$HPV11_02; Quality: 6; HPV-11, human papilloma virus type 11 BS R00731; HPV$HPV11_03; Quality: 6; HPV-11, human papilloma virus type 11 BS R00732; HPV$HPV11_04; Quality: 6; HPV-11, human papilloma virus type 11 BS R00733; HPV$HPV16_01; Quality: 6; HPV-16, human papilloma virus type 16 BS R00734; HPV$HPV16_02; Quality: 6; HPV-16, human papilloma virus type 16 BS R00735; HPV$HPV16_03; Quality: 6; HPV-16, human papilloma virus type 16 BS R00738; HPV$HPV16_06; Quality: 6; HPV-16, human papilloma virus type 16 BS R00739; HPV$HPV16_07; Quality: 6; HPV-16, human papilloma virus type 16 BS R00740; HPV$HPV16_08; Quality: 6; HPV-16, human papilloma virus type 16 BS R00741; HPV$HPV16_09; Quality: 6; HPV-16, human papilloma virus type 16 BS R00744; HPV$HPV18_01; Quality: 6; HPV-18, human papilloma virus type 18 BS R00745; HPV$HPV18_02; Quality: 6; HPV-18, human papilloma virus type 18 BS R00746; HPV$HPV18_03; Quality: 6; HPV-18, human papilloma virus type 18 BS R00724; HPV$HPV8_01; Quality: 6; HPV-8, human papilloma virus type 8 BS R00725; HPV$HPV8_02; Quality: 6; HPV-8, human papilloma virus type 8 BS R00726; HPV$HPV8_03; Quality: 6; HPV-8, human papilloma virus type 8 BS R00727; HPV$HPV8_04; Quality: 6; HPV-8, human papilloma virus type 8 BS R00728; HPV$HPV8_05; Quality: 6; HPV-8, human papilloma virus type 8 BS R03664; HS$APOB_13; Quality: 6; human, Homo sapiens BS R00435; HS$FIB2_01; Quality: 6; human, Homo sapiens BS R00457; HS$FN_04; Quality: 6; human, Homo sapiens BS R04124; HS$GFAP_03; Quality: 5; human, Homo sapiens BS R04125; HS$GFAP_04; Quality: 5; human, Homo sapiens BS R04126; HS$GFAP_05; Quality: 5; human, Homo sapiens BS R00594; HS$GHA_06; Quality: 5; human, Homo sapiens BS R00607; HS$GRH_01; Quality: 6; human, Homo sapiens BS R02705; HT1$HTLV1_17; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R00951; JCV$JCV_01; Quality: 6; JCV, JC polyoma virus BS R00952; JCV$JCV_02; Quality: 6; JCV, JC polyoma virus BS R00953; JCV$JCV_03; Quality: 6; JCV, JC polyoma virus BS R01126; MMTV$MMTV_28; Quality: 6; MMTV, mouse mammary tumor virus BS R00088; MOUSE$ALBU_07; Quality: 6; mouse, Mus musculus BS R03106; MOUSE$AP2_07; Quality: 6; mouse, Mus musculus BS R02209; NF1$CONS; Quality: 6 BS R03993; RAT$A11COL_01; Quality: 4; rat, Rattus norvegicus BS R03994; RAT$A11COL_02; Quality: 4; rat, Rattus norvegicus BS R03995; RAT$A11COL_03; Quality: 4; rat, Rattus norvegicus BS R01624; RAT$A1I3_02; Quality: 6; rat, Rattus norvegicus BS R01357; SL3$SL3_01; Quality: 6; SL3-3 virus BS R01588; XENLA$VITB1_02; Quality: 6; clawed frog, Xenopus laevis XX DR EMBL: X12492; HSCTF1(r). DR SwissProt: P08651; NFI1_HUMAN. DR PIR: S01038; S01038. XX RN [1] RA Mermod N., Williams T. J., Tjian R. RT Enhancer binding factors AP-4 and AP-1 act in concert RT to activate SV40 late transcription in vitro RL Nature 332:557-561 (1988). RN [2] RA Shaul Y., Ben-Levy R., De-Medina T. RT High affinity binding site for nuclear factor I next RT to the hepatitis B virus S gene promotor RL EMBO J. 5:1967-1971 (1986). RN [3] RA Rosenfeld P. J., Kelly T. J. RT Purification of Nuclear Factor I by DNA Recognition RT Site Affinity Chromatography RL J. Biol. Chem. 261:1398-1408 (1986). RN [4] RA Rossi P., Karsenty G., Roberts A. B., Roche N. S., RA Sporn M. B., de Crombrugghe B. RT A Nuclear Factor I Binding Site Mediates the Transcriptional RT Activation of a Type I Collagen Promoter by Transforming Growth Factor-beta RL Cell 52:405-414 (1988). RN [5] RA Gustafson T. A., Kedes L. RT Identification of Multiple Proteins That Interact RT with Functional Regions of the Human Cardiac alpha-Actin Promoter RL Mol. Cell. Biol. 9:3269-3283 (1989). RN [6] RA Chakraborty T., Das G. C. RT Identification of HeLa Cell Nuclear Factors That Bind RT to and Activate the Early Promoter of Human Polyomavirus BK In Vitro RL Mol. Cell. Biol. 9:3821-3828 (1989). RN [7] RA Garcia J., Wu F., Gaynor R. RT Upstream regulatory regions required to stabilize RT binding to the TATA sequence in an adenovirus early promoter RL Nucleic Acids Res. 15:8367-8385 (1987). RN [8] RA Adhya S., Shneidman P. S., Hurwitz J. RT Reconstruction of adenovirus replication origins with RT a human nuclear factor I binding site RL J. Biol. Chem. 261:3339-3346 (1986). RN [9] RA Gronostajski R. M., Nagata K., Hurwitz J. RT Isolation of human DNA sequences that bind to nuclear RT factor I, a host protein involved in adenovirus DNA replication RL Proc. Natl. Acad. Sci. USA 81:4013-4017 (1984). RN [10] RA Dean D. C., Blakeley M. S., Newby R. F., Ghazal P., RA Hennighausen L., Bourgeois S. RT Forskolin Inducibility and Tissue-Specific Expression RT of the Fibronectin Promoter RL Mol. Cell. Biol. 9:1498-1506 (1989). RN [11] RA Shelbourn S. L., Kothari S. K., Sissons J. G. P., Sinclair J. H. RT Repression of human cytomegalovirus gene expression RT associated with a novel immediate early regulatory region binding factor RL Nucleic Acids Res. 17:9165ff (1989). RN [12] RA Toohey M. G., Jones K. A. RT In vitro formation of short RNA polymerase II transcripts RT that terminate within the HIV-1 and HIV-2 promoter-proximal RT downstream regions RL Genes Dev. 3:265-282 (1989). RN [13] RA Catala F., deBoer E., Habets G., Grosveld F. RT Nuclear protein factors and erythroid transcription RT of the human Agamma-globin gene RL Nucleic Acids Res. 17:3811-3827 (1989). RN [14] RA Courtois S. J., Lafontaine D. A., Lemaigre F. P., RA Durviaux S. M., Rousseau G. G. RT Nuclear factor-I and activator protein-2 bind in a RT mutually exclusive way to overlapping promoter sequences RT and trans-activate the human growth hormone gene RL Nucleic Acids Res. 18:57-64 (1990). RN [15] RA Ben-Levy R., Faktor O., Berger I., Shaul Y. RT Cellular Factors That Interact with the Hepatitis B Virus Enhancer RL Mol. Cell. Biol. 9:1804-1809 (1989). RN [16] RA Gloss B., Yeo-Gloss M., Meisterernst M., Rogge L., RA Winnacker E. L., Bernard H.-U. RT Clusters of nuclear factor I binding sites identify RT enhancers of several papillomaviruses but lone are RT not sufficient for enhancer function RL Nucleic Acids Res. 17:3519-3533 (1989). RN [17] RA Trujillo M. A., Letovsky J., Maguire H. F., Lopez-Cabrera M., Siddiqui A. RT Functional analysis of a liver-specific enhancer of the hepatitis B virus RL Proc. Natl. Acad. Sci. USA 88:3797-3801 (1991). RN [18] RA Hennighausen L., Fleckenstein B. RT Nuclear factor 1 interacts with five DNA elements RT in the promoter region of the human cytomegalovirus RT major immediate early gene RL EMBO J. 5:1367-1371 (1986). RN [19] RA Pecorino L. T., Darrow A. L., Strickland S. RT In vitro analysis of the tissue plasminogen activator RT promoter reveals a GC box-binding activity present RT in murine brain but undetectable in kidney and liver RL Mol. Cell. Biol. 11:3139-3147 (1991). RN [20] RA Ghazal P., Lubon H., Fleckenstein B., Hennighausen L. RT Binding of transcription factors and creation of a RT large nucleoprotein complex on the human cytomegalovirus enhancer RL Proc. Natl. Acad. Sci. USA 84:3658-3662 (1987). RN [21] RA Diffley J. F. X., Stillman B. RT Purification of a cellular, double-stranded DNA-binding RT protein required for initiation of adenovirus DNA RT replication by using a rapid filter-binding assay RL Mol. Cell. Biol. 6:1363-1373 (1986). RN [22] RA Cleat P. H., Hay R. T. RT Co-operative interactions between NFI and the adenovirus RT DNA binding protein at the adenovirus origin of replication RL EMBO J. 8:1841-1848 (1989). RN [23] RA Amemiya K., Traub R., Durham L., Major E. O. RT Interaction of a Nuclear Factor-1-like Protein with RT the Regulatory Region of Human Polyomavirus JC Virus RL J. Biol. Chem. 264:7025-7032 (1989). RN [24] RA Janson L., Weller P., Pettersson U. RT Nuclear Factor I can Functionally Replace Transcription RT Factor Sp1 in a U2 Small Nuclear RNA Gene Enhancer RL J. Mol. Biol. 205:387-396 (1989). RN [25] RA Mul Y. M., Verrijzer C. P., van der Vliet P. C. RT Transcription factors NFI and NFIII/oct-1 function RT independently, employing different mechanisms to enhance RT adenovirus DNA replication RL J. Virol. 64:5510-5518 (1990). RN [26] RA Goyal N., Knox J., Gronostajski R. M. RT Analysis of multiple forms of nuclear factor I in RT human and murine cell lines RL Mol. Cell. Biol. 10:1041-1048 (1990). RN [27] RA Gounari F., De Francesco R., Schmitt J., van der Vliet RA P., Cortese R., Stunnenberg H. RT Amino-terminal domain of NF1 binds to DNA as a dimer RT and activates adenovirus DNA replication RL EMBO J. 9:559-566 (1990). XX // AC T00540 XX ID T00540 XX DT 15.10.92 (created); ewi. XX FA NFalpha1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01422; MOUSE$TRAL_01; Quality: 6; mouse, Mus musculus XX RN [1] RA Winoto A., Baltimore D. RT A novel, inducible and T cell-specific enhancer located RT at the 3' end of the T cell receptor alpha locus RL EMBO J. 8:729-733 (1989). XX // AC T00541 XX ID T00541 XX DT 15.10.92 (created); ewi. XX FA NFalpha2 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01423; MOUSE$TRAL_02; Quality: 6; mouse, Mus musculus XX RN [1] RA Winoto A., Baltimore D. RT A novel, inducible and T cell-specific enhancer located RT at the 3' end of the T cell receptor alpha locus RL EMBO J. 8:729-733 (1989). XX // AC T00542 XX ID T00542 XX DT 15.10.92 (created); ewi. XX FA NFalpha3 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01424; MOUSE$TRAL_03; Quality: 6; mouse, Mus musculus XX RN [1] RA Winoto A., Baltimore D. RT A novel, inducible and T cell-specific enhancer located RT at the 3' end of the T cell receptor alpha locus RL EMBO J. 8:729-733 (1989). XX // AC T00543 XX ID T00543 XX DT 15.10.92 (created); ewi. XX FA NFalpha4 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01425; MOUSE$TRAL_04; Quality: 6; mouse, Mus musculus XX RN [1] RA Winoto A., Baltimore D. RT A novel, inducible and T cell-specific enhancer located RT at the 3' end of the T cell receptor alpha locus RL EMBO J. 8:729-733 (1989). XX // AC T00544 XX ID T00544 XX DT 25.01.93 (created); ewi. DT 14.08.96 (updated); ewi. XX FA NF-1A1 XX SY NFI-A1; RPF-A (hamster); XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL ; ; 1.4.1.0.1.1. XX SZ 522 AA; 57.5 kDa (cDNA) XX SQ MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDEL SQ LSEKPEVKQKWASRLLAKLRKDIRPEFREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCL SQ RQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLA SQ YFVHAADSSQSESPSQPSEADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGT SQ GPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRIKSVEDEMDSPGEEPFYTSQGRS SQ PGSGSQSSGWHEVEPGYLRNPEHRGALHGMPSPTALKKSEKSGFSSPSPSQTSSLGTAFT SQ QHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDA SQ GQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGA SQ TSPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG XX SC SwissProt #P17923 XX FT 482 490 polII CTD-homologous SPTSPTYST peptide FT 316 328 missing in NF-1A1.1, -A4 FT 487 522 replaced by 474-498 in NF-1A4 FT 316 371 missing in NF-1A5 FT 427 431 missing in NF-1A5 XX SF six splice variants encoded by the NF-1A gene are SF known: A1, A1.1, A3, A4, A5, A6 [1]; XX IN T00544; NF-1A1; chick, Gallus gallus. IN T00552; NF-1B2; chick, Gallus gallus. IN T00554; NF-1C2; chick, Gallus gallus. IN T01903; NF-1X; chick, Gallus gallus. IN T01904; NF-1A1.1; chick, Gallus gallus. IN T01905; NF-1A4; chick, Gallus gallus. IN T01906; NF-1A5; chick, Gallus gallus. IN T01907; NF-1C1; chick, Gallus gallus. IN T01908; NF-1C4; chick, Gallus gallus. XX MX M00056; V$MYOGNF1_01 XX BS R02209; NF1$CONS; Quality: 6 XX DR EMBL: X51486; GGNFIA1(r). DR SwissProt: P17923; NFIA_CHICK. DR PIR: S09996; S09996. XX RN [1] RA Kruse U., Sippel A. E. RT The genes for transcription factor nuclear factor RT I give rise to corresponding splice variants between vertebrate species RL J. Mol. Biol. 238:860-865 (1994). RN [2] RA Kruse U., Sippel A. E. RT Transcription factor nuclear factor I proteins form RT stable homo- and heterodimers RL FEBS Lett. 348:46-50 (1994). RN [3] RA Rupp R. A. W., Kruse U., Multhaup G., Goebel U., Beyreuther K., Sippel A. E. RT Chicken NFI/TGGCA proteins are encoded by at least RT three independent genes: NFI-A, NFI-B and NFI-C with RT homologues in mammalian genomes RL Nucleic Acids Res. 18:2607-2616 (1990). XX // AC T00545 XX ID T00545 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NF-A XX SY IgNF-A; NF-A1; NF-A2; oct-B1A; oct-B1B; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; . XX MX M00210; V$OCT_C XX BS R00834; HS$IGH_02; Quality: 6; human, Homo sapiens BS R01508; HS$U4CSN_01; Quality: 6; human, Homo sapiens BS R00835; MOUSE$IGH_01; Quality: 6; mouse, Mus musculus BS R00855; MOUSE$IGH_21; Quality: 6; mouse, Mus musculus BS R00872; MOUSE$IGH_38; Quality: 6; mouse, Mus musculus XX RN [1] RA Weller P., Bark C., Janson L., Pettersson U. RT Transcription analysis of a human U4C gene: involvement RT of transcription factors novel to snRNA gene expression RL Genes Dev. 2:1389-1399 (1988). RN [2] RA Singh H., Sen R., Baltimore D., Sharp P. A. RT A nuclear factor that binds to a conserved sequence RT motif in transcriptional control elements of immunoglobulin genes RL Nature 319:154-158 (1986). RN [3] RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). XX // AC T00546 XX ID T00546 XX DT 15.10.92 (created); ewi. XX FA NF-A3 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00889; MOUSE$IGKL_13; Quality: 6; mouse, Mus musculus XX RN [1] RA Lenardo M.-J., Staudt L., Robbins P., Kuang A., Mulligan R. C., Baltimore D. RT Repression of the IgH enhancer in teratocarcinoma RT cells associated with a novel octamer factor RL Science 243:544-546 (1989). XX // AC T00547 XX ID T00547 XX DT 15.03.93 (created); ewi. XX FA NF-AB XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 37 kDa (SDS) XX CP (liver) XX FF heat-labile; FF involved in regulation by IL-1 XX RN [1] RA Won K.-A., Baumann H. RT NF-AB, a liver-specific and cytokine-inducible nuclear RT factor that interacts with the interleukin-1 response RT element of the rat alpha1-acid glycoprotein gene RL Mol. Cell. Biol. 11:3001-3008 (1991). XX // AC T00548 XX ID T00548 XX DT 15.03.93 (created); ewi. XX FA NF-AB XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 34.5 kDa (SDS) XX CP (liver) XX FF heat-labile; FF induced wihtin 13 h after IL-1 treatment XX RN [1] RA Won K.-A., Baumann H. RT NF-AB, a liver-specific and cytokine-inducible nuclear RT factor that interacts with the interleukin-1 response RT element of the rat alpha1-acid glycoprotein gene RL Mol. Cell. Biol. 11:3001-3008 (1991). XX // AC T00549 XX ID T00549 XX DT 26.01.93 (created); hse. DT 15.11.96 (updated); ewi. XX FA NF-AT XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SF composed of an AP-1 [10], [3], [1], [5] and a Rel-like SF component [10], [2], [5], [4]; XX CP activated T cells XX BS R02210; NFAT$CONS; Quality: 6 XX DR Compel: C00108 XX RN [1] RA Northrop J. P., Ullman K. S., Crabtree G. R. RT Characterization of the nuclear and cytoplasmic components RT of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex RL J. Biol. Chem. 268:2917-2923 (1993). RN [2] RA McCaffrey P. G., Perrino B. A., Soderling T. R., Rao A. RT NF-ATp, a T lymphocyte DNA-binding protein that is RT a target for calcineurin and immunosuppressive drugs RL J. Biol. Chem. 268:3747-3752 (1993). RN [3] RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., RA Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B. RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB RL Mol. Cell. Biol. 13:1911-1919 (1993). RN [4] RA McCaffrey P. G., Luo C., Kerpolla T. K., Jain J., RA Badalian T. M., Ho A. M., Burgeon E., Lane W. S., RA Lambert J. N., Curran T., Verdine G. L., Rao A., Hogan P. G. RT Isolation of the cyclosporin-sensitive T cell transcription factor NFATp RL Science 262:750-754 (1993). RN [5] RA Jain J., McCaffrey P. G., Miner Z., Kerpolla T. K., RA Lambert J. N., Verdine G. L., Curran T., Rao A. RT The T-cell transcription factor NFATp is a substrate RT for calcineurin and interacts with Fos and Jun RL Nature 365:352-355 (1993). RN [6] RA Randak C., Brabletz T., Hergenroether M., Sobotta I., Serfling E. RT Cyclosporin A suppresses the expression of the interleukin RT 2 gene by inhibiting the binding of lymphocyte-specific RT factors to the IL-2 enhancer RL EMBO J. 9:2529-2536 (1990). RN [7] RA Fiering S., Northrop J. P., Nolan G. P., Mattila P. RA S., Crabtree G. R., Herzenberg L. A. RT Single cell assay of a transcription factor reveals RT a threshold in transcription activated by signals RT emanating from the T-cell antigen receptor RL Genes Dev. 4:1823-1834 (1990). RN [8] RA Flanagan W. M., Corthesy B., Bram R. J., Crabtree G. R. RT Nuclear association of a T-cell transcription factor RT blocked by FK-506 and cyclosporin A RL Nature 352:803-807 (1991). RN [9] RA Emmel E. A., Verweij C. L., Durand D. B., Higgins RA K. M., Lacy E., Crabtree G. R. RT Cyclosporin A specifically inhibits function of nuclear RT proteins involved in T cell activation RL Science 246:1617-1620 (1989). RN [10] RA Jain J., McCaffrey P. G., Valge-Archer V. E., Rao A. RT Nuclear factor of activated T cells contain Fos and Jun RL Nature 356:801-804 (1992). XX // AC T00550 XX ID T00550 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA NFAT-1 XX SY NF-AT1; NF-IL-2E; NFII-a; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SF associates with Fos/Jun upon activation XX CP T-cells XX FF induced in T-cells through T-cell receptor/CD3; FF activity, but not DNA-binding inhibited by CsA or FK-506 XX BS R00697; HIV1$HIV1_04; Quality: 4; HIV-1, human immunodeficiency virus type 1 BS R00930; HS$IL2_01; Quality: 2; human, Homo sapiens BS R00931; HS$IL2_02; Quality: 5; human, Homo sapiens BS R02348; MOUSE$IL2_01; Quality: 1; mouse, Mus musculus BS R02210; NFAT$CONS; Quality: 6 XX RN [1] RA Durand D. B., Shaw J.-P., Bush M. R., Replogle R. RA E., Belagaje R., Crabtree G. R. RT Characterization of Antigen Receptor Response Elements RT within the Interleukin-2 Enhancer RL Mol. Cell. Biol. 8:1715-1724 (1988). RN [2] RA Shaw J.-P., Utz P. J., Durand D. B., Toole J. J., RA Emmel E. A., Crabtree G. R. RT Identification of a Putative Regulator of Early T Cell Activation Genes RL Science 241:202-205 (1988). RN [3] RA Brunvand M. W., Schmidt A., Siebenlist U. RT Nuclear Factors Interacting with the Mitogen-responsive RT Regulatory Region of the Interleukin-2 Gene RL J. Biol. Chem. 263:18904-18910 (1988). RN [4] RA Banerji S. S., Parsons J. N., Tocci M. J. RT The immunosuppressant FK-506 specifically inhibits RT mitogen-induced activation of the interleukin-2 promoter RT and the isolated enhancer elements NFIL-2A and NF-AT1 RL Mol. Cell. Biol. 11:4074-4087 (1991). RN [5] RA Randak C., Brabletz T., Hergenroether M., Sobotta I., Serfling E. RT Cyclosporin A suppresses the expression of the interleukin RT 2 gene by inhibiting the binding of lymphocyte-specific RT factors to the IL-2 enhancer RL EMBO J. 9:2529-2536 (1990). RN [6] RA Fiering S., Northrop J. P., Nolan G. P., Mattila P. RA S., Crabtree G. R., Herzenberg L. A. RT Single cell assay of a transcription factor reveals RT a threshold in transcription activated by signals RT emanating from the T-cell antigen receptor RL Genes Dev. 4:1823-1834 (1990). RN [7] RA Flanagan W. M., Corthesy B., Bram R. J., Crabtree G. R. RT Nuclear association of a T-cell transcription factor RT blocked by FK-506 and cyclosporin A RL Nature 352:803-807 (1991). RN [8] RA Emmel E. A., Verweij C. L., Durand D. B., Higgins RA K. M., Lacy E., Crabtree G. R. RT Cyclosporin A specifically inhibits function of nuclear RT proteins involved in T cell activation RL Science 246:1617-1620 (1989). RN [9] RA Jain J., McCaffrey P. G., Valge-Archer V. E., Rao A. RT Nuclear factor of activated T cells contain Fos and Jun RL Nature 356:801-804 (1992). XX // AC T00551 XX ID T00551 XX DT 25.01.93 (created); ewi. DT 15.08.96 (updated); ewi. XX FA NF-1B1 XX SY NF-1/Red1 (hamster); NFI-B1; RPF-B; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL ; ; 1.4.1.0.2.1. XX SZ 560 AA; 62.6 kDa (cDNA) XX SQ MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDE SQ LLSEKPEIKQKWASRLLAKLRKDIRQEFREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDC SQ LRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFL SQ AYYVQEQDSGQPGSPSHNDPAKNPPVYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFP SQ IGELPSQPYYHDMNSGINLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPNSPAAGS SQ RTWHERDQDMSSPTMKKPEKPLFSPTSPQDSSPRLSTFPQHHHPGIPGVAQSVISTRTPP SQ SPSPLPFPAQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNSSGQ SQ VVGKVPGHFTPVLAPSPHHSAVRPVTLTMTDTKPITTSTEAYTASGTSQANRYVGLSPRD SQ PSFLHQQQLRICDWTMNQNGRHLYPSASEDTLGITWQSPGTWASLVPFQVSNRTPILPTN SQ VPNYGLNIIGEPFLQAESSN XX SC SwissProt #P17924 XX FT 415 560 replaced by 415-419 in NF-1B2 XX SF splice variant: NF-1B2 XX MX M00056; V$MYOGNF1_01 XX BS R01162; MOUSE$MBP_01; Quality: 6; mouse, Mus musculus BS R02209; NF1$CONS; Quality: 6 XX DR EMBL: X51485; GGNFIB1(r). DR SwissProt: P17924; NFI1_CHICK. DR PIR: S09995; S09995. XX RN [1] RA Kruse U., Sippel A. E. RT The genes for transcription factor nuclear factor RT I give rise to corresponding splice variants between vertebrate species RL J. Mol. Biol. 238:860-865 (1994). RN [2] RA Rupp R. A. W., Kruse U., Multhaup G., Goebel U., Beyreuther K., Sippel A. E. RT Chicken NFI/TGGCA proteins are encoded by at least RT three independent genes: NFI-A, NFI-B and NFI-C with RT homologues in mammalian genomes RL Nucleic Acids Res. 18:2607-2616 (1990). XX // AC T00552 XX ID T00552 XX DT 25.01.93 (created); ewi. DT 15.08.96 (updated); ewi. XX FA NF-1B2 XX SY NFI-B2; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL ; ; 1.4.1.0.2.2. XX SZ 419 AA; 47.4 kDa (cDNA) XX SQ MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDE SQ LLSEKPEIKQKWASRLLAKLRKDIRQEFREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDC SQ LRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFL SQ AYYVQEQDSGQPGSPSHNDPAKNPPVYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFP SQ IGELPSQPYYHDMNSGINLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPNSPAAGS SQ RTWHERDQDMSSPTMKKPEKPLFSPTSPQDSSPRLSTFPQHHHPGIPGVAQSVISTRTPP SQ SPSPLPFPAQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQSWYLG XX SC SwissProt #P17925 XX FT 415 419 replaced by 415-560 in NF-1B1 XX SF splice variant: NF-1B1 XX IN T00544; NF-1A1; chick, Gallus gallus. IN T00552; NF-1B2; chick, Gallus gallus. IN T00554; NF-1C2; chick, Gallus gallus. IN T01903; NF-1X; chick, Gallus gallus. IN T01904; NF-1A1.1; chick, Gallus gallus. IN T01905; NF-1A4; chick, Gallus gallus. IN T01906; NF-1A5; chick, Gallus gallus. IN T01907; NF-1C1; chick, Gallus gallus. IN T01908; NF-1C4; chick, Gallus gallus. XX MX M00056; V$MYOGNF1_01 XX BS R02209; NF1$CONS; Quality: 6 XX DR EMBL: X51485; GGNFIB1(r). DR SwissProt: P17925; NFI2_CHICK. DR PIR: S09997; S09997. XX RN [1] RA Kruse U., Sippel A. E. RT The genes for transcription factor nuclear factor RT I give rise to corresponding splice variants between vertebrate species RL J. Mol. Biol. 238:860-865 (1994). RN [2] RA Kruse U., Sippel A. E. RT Transcription factor nuclear factor I proteins form RT stable homo- and heterodimers RL FEBS Lett. 348:46-50 (1994). RN [3] RA Rupp R. A. W., Kruse U., Multhaup G., Goebel U., Beyreuther K., Sippel A. E. RT Chicken NFI/TGGCA proteins are encoded by at least RT three independent genes: NFI-A, NFI-B and NFI-C with RT homologues in mammalian genomes RL Nucleic Acids Res. 18:2607-2616 (1990). XX // AC T00553 XX ID T00553 XX DT 25.01.93 (created); ewi. DT 14.05.94 (updated); ewi. XX FA NF-BA1 XX SY CIIIB2; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO AF-1, LF-A1, Tf-LF1 XX SZ 60 kDa (SDS) XX FF activator XX BS R00135; HS$APOA1_01; Quality: 6; human, Homo sapiens BS R00140; HS$APOA2_05; Quality: 6; human, Homo sapiens BS R01612; HS$APOB_01; Quality: 6; human, Homo sapiens BS R02657; HS$APOC3_01; Quality: 2; human, Homo sapiens XX RN [1] RA Kardassis D., Zannis V. I., Claradas C. RT Purification and characterization of the nuclear factor BA1 RL J. Biol. Chem. 265:31733-21740 (1990). XX // AC T00554 XX ID T00554 XX DT 25.01.93 (created); ewi. DT 15.08.96 (updated); ewi. XX FA NF-1C2 XX SY CTF-2 (human); NFI-C2; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL ; ; 1.4.1.0.3.2. XX SZ 439 AA; 49.2 kDa (cDNA) XX SQ MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMTKDEERAVKDE SQ LLSEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKPSCCVLSNPDQKGKMRRIDC SQ LRQADKVWRLDLVMVILFKGIPLESTDGERLVKAGQCTNPILCIQPHHISVSVKELDLYL SQ AYFVRERDSEQSSSPRTGIASDQEDTKPNTLDSTDFQESFVTSGVFSVTELIQVSRTPVV SQ TGTGPNFSLGELQGHLAYDLNPSSTGMRRTLPSTSSSGSKRHKSGSMEDDIDTSPGGEYY SQ TSSNSPTSSSRNWTEDMEGGISPNVKTEMDKSPFNSPSPQDSSPRLSSFTQHHRPVIAVH SQ SGIARSPHPSSTLHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPSNQQ SQ PGPPTLHQARPLRTVPSWD XX SC SwissProt #P17926 XX FT 1 220 DNA-binding and dimerization domain FT 179 202 encoded by alternative exon 3, absent in CTF-3 FT 388 427 proline-rich region FT 424 510 replaced by 424-439 in NF-1C1 FT 424 439 replaced by 413-417 in NF-1C4 XX SF 3-4 splice variants encoded by the NF-1C gene: NF-1C1/CTF-1, SF NF-1C2/CTF-2, NF-1C4 and (from human sources) CTF-3 [1]; XX IN T00544; NF-1A1; chick, Gallus gallus. IN T00552; NF-1B2; chick, Gallus gallus. IN T00554; NF-1C2; chick, Gallus gallus. IN T01903; NF-1X; chick, Gallus gallus. IN T01904; NF-1A1.1; chick, Gallus gallus. IN T01905; NF-1A4; chick, Gallus gallus. IN T01906; NF-1A5; chick, Gallus gallus. IN T01907; NF-1C1; chick, Gallus gallus. IN T01908; NF-1C4; chick, Gallus gallus. XX MX M00056; V$MYOGNF1_01 XX BS R02209; NF1$CONS; Quality: 6 XX DR EMBL: X51483; GGNFIC2(r). DR SwissProt: P17926; NFIC_CHICK. DR PIR: S09998; S09998. XX RN [1] RA Kruse U., Sippel A. E. RT The genes for transcription factor nuclear factor RT I give rise to corresponding splice variants between vertebrate species RL J. Mol. Biol. 238:860-865 (1994). RN [2] RA Kruse U., Sippel A. E. RT Transcription factor nuclear factor I proteins form RT stable homo- and heterodimers RL FEBS Lett. 348:46-50 (1994). RN [3] RA Rupp R. A. W., Kruse U., Multhaup G., Goebel U., Beyreuther K., Sippel A. E. RT Chicken NFI/TGGCA proteins are encoded by at least RT three independent genes: NFI-A, NFI-B and NFI-C with RT homologues in mammalian genomes RL Nucleic Acids Res. 18:2607-2616 (1990). XX // AC T00555 XX ID T00555 XX DT 26.01.93 (created); hse. XX FA NF-D XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX FF acts on Py enhancer domain D XX BS R02212; NFD$CONS; Quality: 6 BS R01219; PA$PY_01; Quality: 6; Py, polyoma virus XX RN [1] RA Caruso M., Iacobini C., Passanati C., Felsani A., Amati P. RT Protein recognition sites in polyomavirus enhancer: RT formation of a novel site for NF-1 factor in an enhancer RT mutant and characterization of a site in the enhancer D domain RL EMBO J. 9:947-955 (1990). XX // AC T00556 XX ID T00556 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); hwi; ewi. XX FA NF-E XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00561; HS$GG_15; Quality: 6; human, Homo sapiens XX RN [1] RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M. RT The -117 mutation in Greek HPFH affects the binding RT of three nuclear factors to the CCAAT region of the gamma-globin gene RL EMBO J. 7:3099-3107 (1988). RN [2] RA Mantovani R., Malgarettie N., Nicolis S., Ronchi A., RA Giglioni B., Ottolenghi S. RT The effects of HPFH mutations in the human gamma-globin RT promoter on binding of ubiquitous and erythroid specific nuclear factors RL Nucleic Acids Res. 16:7783-7797 (1988). XX // AC T00557 XX ID T00557 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA NF-E2 XX SY NFE2; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SF AP-1-like SF two subunits: a ubiquitous small Maf component (NF-E2 SF p18) and a erythroid-specific larger polypeptide (NF-E2 p45) XX CP fetal liver, myeloid cells XX FF governs erythroid-specific transcriptional activation XX MX M00037; V$NFE2_01 XX BS R02887; HS$AG_07; Quality: 6; human, Homo sapiens BS R03439; HS$AG_10; Quality: 6; human, Homo sapiens BS R03440; HS$AG_11; Quality: 6; human, Homo sapiens BS R02453; HS$BG_11; Quality: 6; human, Homo sapiens BS R04288; HS$BG_15; Quality: 5; human, Homo sapiens BS R04293; HS$BG_20; Quality: 5; human, Homo sapiens BS R01249; HS$PBGD_03; Quality: 2; human, Homo sapiens BS R01250; HS$PBGD_04; Quality: 6; human, Homo sapiens BS R01251; HS$PBGD_05; Quality: 6; human, Homo sapiens BS R02211; NFE2$CONS_01; Quality: 6 BS R04115; NFE2$CONS_02; Quality: 6 XX DR EMBL: L09600; MMTFNFE2X(r). XX RN [1] RA Mignotte V., Wall L., deBoer E., Grosveld F., Romeo P.-H. RT Two tissue-specific factors bind to the erythroid RT promoter of the human porphobilinogen deaminase gene RL Nucleic Acids Res. 17:37-54 (1989). RN [2] RA Andrews N. C., Erdjument-Bromage H., Davidson M. B., Tempst P., Orkin S. H. RT Erythroid transcription factor NF-E2 is a haematopoietic-specific RT basic-leucine zipper protein RL Nature 362:722-728 (1993). RN [3] RA Andrews N. C., Kotkow K. J., Ney P. A., Erdjument-Bromage RA H., Tempst P., Orkin S. H. RT The ubiquitous subunit of erythroid transcription RT factor NF-E2 is a small basic-leucine zipper protein RT related to the v-Maf oncogene RL Proc. Natl. Acad. Sci. USA 90:11488-11492 (1993). RN [4] RA Andrews N. C., Erdjument-Bromage H., Davidson M. B., Tempst P., Orkin S. H. RT Erythroid transcription factor NF-E2 is a haematopoietic-specific RT basic-leucine zipper protein RL Nature 362:722-728 (1993). RN [5] RA Talbot D., Grosveld F. RT The 5'HS2 of the globin locus control region enhances RT transcription through the interaction of a multimeric RT complex binding at two functionally distinct NF-E2 binding sites RL EMBO J. 10:1391-1398 (1991). XX // AC T00558 XX ID T00558 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA NF-E2 XX SY NFE2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SF AP-1-like SF two subunits: a ubiquitous small Maf component (NF-E2 SF p18) and a erythroid-specific larger polypeptide (NF-E2 p45) XX FF down-regulated by TPA [8]; FF governs erythroid-specific transcriptional activation XX MX M00037; V$NFE2_01 XX BS R02887; HS$AG_07; Quality: 6; human, Homo sapiens BS R03439; HS$AG_10; Quality: 2; human, Homo sapiens BS R03440; HS$AG_11; Quality: 2; human, Homo sapiens BS R02420; HS$BG_10; Quality: 6; human, Homo sapiens BS R02453; HS$BG_11; Quality: 6; human, Homo sapiens BS R01248; HS$PBGD_02; Quality: 6; human, Homo sapiens BS R01249; HS$PBGD_03; Quality: 6; human, Homo sapiens BS R01250; HS$PBGD_04; Quality: 6; human, Homo sapiens BS R01251; HS$PBGD_05; Quality: 6; human, Homo sapiens BS R02211; NFE2$CONS_01; Quality: 6 XX DR EMBL: L24122; HSNFE2A(r). XX RN [1] RA Mignotte V., Wall L., deBoer E., Grosveld F., Romeo P.-H. RT Two tissue-specific factors bind to the erythroid RT promoter of the human porphobilinogen deaminase gene RL Nucleic Acids Res. 17:37-54 (1989). RN [2] RA Mignotte V., Eleouet J. F., Raich N., Romeo P.-H. RT Cis- and trans-acting elements involved in the regulation RT of the erythroid promoter of the human porphobilinogen deaminase gene RL Proc. Natl. Acad. Sci. USA 86:6548-6552 (1989). RN [3] RA Igarashi K., Kataoka K., Itoh K., Hayashi N., Nishizawa M., Yamamoto M. RT Regulation of transcription by dimerization of erythroid RT factor NF-E2 p45 with small Maf proteins RL Nature 367:568-572 (1994). RN [4] RA Chan J. Y., Han X.-L., Kan Y. W. RT Isolation of cDNA encoding the human NF-E2 protein RL Proc. Natl. Acad. Sci. USA 90:11366-11370 (1993). RN [5] RA Ney P. A., Andrews N. C., Jane S. M., Safer B., Purucker RA M. E., Weremowicz S., Morton C. C., Goff S. C., Orkin S. H., Nienhuis A. W. RT Purification of the human NF-E2 complex: cDNA cloning RT of the hematopoietic cell-specific subunit and evidence RT for an associated partner RL Mol. Cell. Biol. 13:5604-5612 (1993). RN [6] RA Dillon N., Grosveld F. RT Transcriptional regulation of multigene loci: multilevel control RL Trends Genet. 9:134-137 (1993). RN [7] RA Pischedda C., Cocco S., Melis A., Marini M. G., Kan Y. W., Cao A., Moi P. RT Isolation of a differentially regulated splicing isoform of human NF-E2 RL Proc. Natl. Acad. Sci. USA 92:3511-3515 (1995). RN [8] RA Mignotte V., Navarro S., Eleouet F.-F., Zon L. I., Romeo P.-H. RT The extinction of erythroid genes after tetradecanoylphorbol RT acetate treatment of erythroleukemic cells correlates RT with down-regulation of the tissue-specific factors NF-E1 and NF-E2 RL J. Biol. Chem. 265:22090-22092 (1990). RN [9] RA Ney P. A., Sorrentino B. P., Lowrey Ch. H., Nienhuis A. W. RT Inducibility of the HS II enhancer depends on binding RT of an erythroid specific nuclear protein RL Nucleic Acids Res. 18:6011-6017 (1990). XX // AC T00559 XX ID T00559 XX DT 15.10.92 (created); ewi. XX FA NF-E3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01859; HS$GG_20; Quality: 6; human, Homo sapiens XX RN [1] RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S. RT The deletion of the distal CCAAT box region of the RT Agamma-globin gene in black HPFH abolishes the binding RT of the erythroid specific protein NFE3 and of the CCAAT displacement protein RL Nucleic Acids Res. 17:6681-6691 (1989). XX // AC T00560 XX ID T00560 XX DT 15.10.92 (created); ewi. XX FA NF-E4 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX SZ 65 kDa (SDS) XX CP mature definitive adult erythroid cells XX BS R01950; CHICK$BG_08; Quality: 2; chick, Gallus gallus XX RN [1] RA Gallarda J. L., Foley K. P., Yang Z., Engel J. D. RT The beta-globin stage selector element factor is erythroid-specific RT promoter/enhancer binding protein NF-E4 RL Genes Dev. 3:1845-1859 (1989). XX // AC T00561 XX ID T00561 XX DT 15.10.92 (created); ewi. XX FA NF-muE1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00848; MOUSE$IGH_14; Quality: 6; mouse, Mus musculus BS R03416; PRV$IE_01; Quality: 6; pseudorabies virus BS R03418; PRV$IE_03; Quality: 6; pseudorabies virus BS R03419; PRV$IE_04; Quality: 6; pseudorabies virus BS R03420; PRV$IE_05; Quality: 6; pseudorabies virus BS R03421; PRV$IE_06; Quality: 6; pseudorabies virus BS R03422; PRV$IE_07; Quality: 6; pseudorabies virus XX RN [1] RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). XX // AC T00562 XX ID T00562 XX DT 15.10.92 (created); ewi. XX FA NF-muE2 XX SY muEBP-B; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX RN [1] RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). XX // AC T00563 XX ID T00563 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); hse; ewi. XX FA NF-muE3 XX SY muEBP-C2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 42.5 + 44 + 45 kDa (SDS) XX BS R00853; MOUSE$IGH_19; Quality: 6; mouse, Mus musculus BS R00887; MOUSE$IGKL_11; Quality: 6; mouse, Mus musculus BS R02218; NFME3$CONS; Quality: 6 XX RN [1] RA Beckmann H., Kadesch T. RT Identification of a Yeast Protein with Properties RT Similar to Those of the Immunoglobulin Heavy-Chain RT Enhancer-Binding Protein NF-muE3 RL Mol. Cell. Biol. 9:4535-4540 (1989). RN [2] RA Peterson C. L., Eaton S., Calame K. RT Purified muEBP-E Binds to Immunoglobulin Enhancers and Promoters RL Mol. Cell. Biol. 8:4972-4980 (1988). RN [3] RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). RN [4] RA Beckmann H., Su L.-K., Kadesch T. RT TFE3: a helix-loop-helix protein that activates transcription RT through the immunoglobulin enhancer E3 motif RL Genes Dev. 4:167-179 (1990). RN [5] RA Atchison M. L., Perry R. P. RT The Role of the kappa Enhancer and Its Binding Factor RT NF-kB in the Developmental Regulation of kappa Gene Transcription RL Cell 48:121-128 (1987). RN [6] RA Baeuerle P. A., Baltimore D. RT Activation of DNA-Binding Activity in an Apparently RT Cytoplasmic Precursor of the NF-kB Transcription Factor RL Cell 53:211-217 (1988). XX // AC T00564 XX ID T00564 XX DT 23.11.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NFE-6 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP erythroid cells/megakaryocytes XX FF tissue-, but not stage-specific XX BS R02441; HS$GPC_01; Quality: 6; human, Homo sapiens XX RN [1] RA Rosenthal N., Berglund E. B., Wentworth B. M., Donoghue RA M., Winter B., Bober E., Braun T., Arnold H.-H. RT A highly conserved enhancer downstream of the human RT MLC1/3 locus is a target for multiple myogenic determination factors RL Nucleic Acids Res. 18:6239 (1990). XX // AC T00565 XX ID T00565 XX DT 15.10.92 (created); ewi. XX FA NFe XX SY NF-E; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R02213; NFE$CONS; Quality: 6 BS R03902; RAT$BMHC_04; Quality: 5; rat, Rattus norvegicus BS R01170; RAT$MHC_01; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Yu Y.-T., Nadal-Ginard B. RT Interaction of Nuclear Proteins with a Positive cis-Acting RT Element of Rat Myosin Heavy-Chain Promoter: Identification RT of a New Transcriptional Factor RL Mol. Cell. Biol. 9:1839-1849 (1989). XX // AC T00566 XX ID T00566 XX DT 26.01.93 (created); hse. XX FA NFe XX SY NF-E; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R02213; NFE$CONS; Quality: 6 BS R03902; RAT$BMHC_04; Quality: 5; rat, Rattus norvegicus XX RN [1] RA Yu Y.-T., Nadal-Ginard B. RT Interaction of Nuclear Proteins with a Positive cis-Acting RT Element of Rat Myosin Heavy-Chain Promoter: Identification RT of a New Transcriptional Factor RL Mol. Cell. Biol. 9:1839-1849 (1989). XX // AC T00567 XX ID T00567 XX DT 28.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA NF-E1b XX SY GATA-2 (human); GF-1; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0003; CC (g); 2.2.1.1.2. XX SZ 466 AA; 50 kDa (cDNA) XX SQ MEVATDQPRWMTHHAVLNGQHPESHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYY SQ ANSAHARARVSYSQAHARLTGSQMCRPHLIHSPGIPWLDSSKAALSAHHHNPWTVNPFTK SQ TPLHPSAAGAPGAISVYPGSSTSSTASVSSLTPASHSGSHLFGFPPTPPKEVSPDPNSTS SQ AASPSSSAGARQEDKDSIKYQVSLSEGMKMESASPLRSSLTSMGAQPSTHHPIPTYPSYV SQ PAAHDYSSSLFHPGSFLGGPASSFTPKPRSKARSCSEGRECVNCGATATPLWRRDGTGHY SQ LCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACG SQ LYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGSECFEELSKCMQEKSSPFSAAALA SQ SHMAPMGHLPPFSHSGHILPTPTPIHPSSSISFGHPHPSSMVTAMG XX SC SwissProt #P23824 XX SF 2 zinc finger motifs SF pI 9.9 XX CP erythroid cells; embryonic brain, liver, cardiac muscle, CP fibroblasts; adult kidney XX MX M00203; V$GATA_C XX BS R00534; CHICK$BAG_08; Quality: 1; chick, Gallus gallus BS R02157; GATA2$CONS; Quality: 2 BS R00507; MOUSE$AAG_01; Quality: 2; mouse, Mus musculus XX DR EMBL: X56930; GDNFE1B(r). DR SwissProt: P23824; GAT2_CHICK. DR PIR: A36389; A36389. XX RN [1] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S., Engel J. D. RT Acitivity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). XX // AC T00568 XX ID T00568 XX DT 28.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA NF-E1c XX SY GATA-3; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0003; CC (g); 2.2.1.1.3. XX SZ 444 AA; 48 kDa (cDNA) XX SQ MEVSTDQPRWVSHHHPAVLNGQHPDSHHPTLGHTYMDPTQYPLAEEVDVLFNIDGQGNPV SQ PPYYGNSVRATVQRYPTAHHGSQVCRPPLLHGSLPWLDGSKALSSHHSASPWNLSPFSKT SQ SIHHSSPGPLSVYPPASSSTLSAGHSSPHLFTFPPTPPKDVSPDPSISTPGSTGSTRQDE SQ KECIKYQVSLADTMKLESSHSRSSMASLGGATSSAHHPITTYPPYVPEYSSGLFPPSSLL SQ GGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRP SQ LIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKE SQ GIQTRNRKMSSKSKKCKKVHDNLEDFPKSSSFNPAALSRHMSSISHISPFSHSSHMLTTP SQ TPMHPPSSLSFGPHHPSSMVTAMG XX SC SwissProt #P23825 XX SF 2 zinc finger motifs SF pI 9.9 XX CP definitive adult erythrocytes; T lymphocytes; brain XX MX M00203; V$GATA_C XX BS R00534; CHICK$BAG_08; Quality: 1; chick, Gallus gallus BS R02158; GATA3$CONS; Quality: 2 BS R00507; MOUSE$AAG_01; Quality: 4; mouse, Mus musculus XX DR EMBL: X56931; GDNFE1C(r). DR SwissProt: P23825; GAT3_CHICK. DR PIR: B36389; B36389. XX RN [1] RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S., Engel J. D. RT Acitivity and tissue-specific expression of the transcription RT factor NF-E1 multigene family RL Genes Dev. 4:1650-1662 (1990). XX // AC T00569 XX ID T00569 XX DT 15.10.92 (created); ewi. XX FA NF-4FA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00005; HS$4F2H_01; Quality: 6; human, Homo sapiens XX RN [1] RA Karpinski B. A., Yang L.-H., Cacheris P., Morle G. D., Leiden J. M. RT The First Intron of the 4F2 Heavy-Chain Gene Contains RT a Transcriptional Enhancer Element That Binds Multiple Nuclear Proteins RL Mol. Cell. Biol. 9:2588-2597 (1989). XX // AC T00570 XX ID T00570 XX DT 15.10.92 (created); ewi. XX FA NF-4FB XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00008; HS$4F2H_04; Quality: 6; human, Homo sapiens XX RN [1] RA Karpinski B. A., Yang L.-H., Cacheris P., Morle G. D., Leiden J. M. RT The First Intron of the 4F2 Heavy-Chain Gene Contains RT a Transcriptional Enhancer Element That Binds Multiple Nuclear Proteins RL Mol. Cell. Biol. 9:2588-2597 (1989). XX // AC T00571 XX ID T00571 XX DT 15.10.92 (created); ewi. XX FA NF-4FC XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00006; HS$4F2H_02; Quality: 6; human, Homo sapiens XX RN [1] RA Karpinski B. A., Yang L.-H., Cacheris P., Morle G. D., Leiden J. M. RT The First Intron of the 4F2 Heavy-Chain Gene Contains RT a Transcriptional Enhancer Element That Binds Multiple Nuclear Proteins RL Mol. Cell. Biol. 9:2588-2597 (1989). XX // AC T00572 XX ID T00572 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NF-GMa XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 43 kda (SDS) XX FF TNF-alpha responsive; FF different from NF-kappaB XX BS R02683; HS$GCSF_01; Quality: 6; human, Homo sapiens BS R00601; HS$GMCSF_01; Quality: 6; human, Homo sapiens BS R00602; HS$GMCSF_02; Quality: 6; human, Homo sapiens BS R02682; HS$IL3_01; Quality: 6; human, Homo sapiens BS R02684; HS$IL5_01; Quality: 6; human, Homo sapiens BS R02214; NFGMA$CONS; Quality: 6 XX RN [1] RA Shannon M. F., Gamble J. R., Vadas M. A. RT Nuclear proteins interacting with the promoter region RT of the human granulocyte/macrophage colony-stimulating factor gene RL Proc. Natl. Acad. Sci. USA 85:674-678 (1988). XX // AC T00573 XX ID T00573 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NF-GMb XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00601; HS$GMCSF_01; Quality: 6; human, Homo sapiens BS R02215; NFGMB$CONS; Quality: 6 XX RN [1] RA Shannon M. F., Gamble J. R., Vadas M. A. RT Nuclear proteins interacting with the promoter region RT of the human granulocyte/macrophage colony-stimulating factor gene RL Proc. Natl. Acad. Sci. USA 85:674-678 (1988). XX // AC T00574 XX ID T00574 XX DT 15.10.92 (created); ewi. XX FA NFH3-1 XX OS sea urchin, Strongylocentrotus purpuratus OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida; strongylocentrotidae XX BS R01898; SP$H3_04; Quality: 6; sea urchin, Strongylocentrotus purpuratus XX RN [1] RA DiLiberto M., Lai Z.-C., Fei H., Childs G. RT Developmental control of the promoter-specific factors RT responsible for the embryonic activation and inactivation RT of the sea urchin early histone H3 gene RL Genes Dev. 3:973-985 (1989). XX // AC T00575 XX ID T00575 XX DT 15.10.92 (created); ewi. XX FA NFH3-2 XX OS sea urchin, Strongylocentrotus purpuratus OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida; strongylocentrotidae XX BS R01897; SP$H3_03; Quality: 6; sea urchin, Strongylocentrotus purpuratus XX RN [1] RA DiLiberto M., Lai Z.-C., Fei H., Childs G. RT Developmental control of the promoter-specific factors RT responsible for the embryonic activation and inactivation RT of the sea urchin early histone H3 gene RL Genes Dev. 3:973-985 (1989). XX // AC T00576 XX ID T00576 XX DT 15.10.92 (created); ewi. XX FA NFH3-3 XX OS sea urchin, Strongylocentrotus purpuratus OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida; strongylocentrotidae XX BS R01896; SP$H3_02; Quality: 6; sea urchin, Strongylocentrotus purpuratus XX RN [1] RA DiLiberto M., Lai Z.-C., Fei H., Childs G. RT Developmental control of the promoter-specific factors RT responsible for the embryonic activation and inactivation RT of the sea urchin early histone H3 gene RL Genes Dev. 3:973-985 (1989). XX // AC T00577 XX ID T00577 XX DT 15.10.92 (created); ewi. XX FA NFH3-4 XX OS sea urchin, Strongylocentrotus purpuratus OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida; strongylocentrotidae XX BS R01895; SP$H3_01; Quality: 6; sea urchin, Strongylocentrotus purpuratus XX RN [1] RA DiLiberto M., Lai Z.-C., Fei H., Childs G. RT Developmental control of the promoter-specific factors RT responsible for the embryonic activation and inactivation RT of the sea urchin early histone H3 gene RL Genes Dev. 3:973-985 (1989). XX // AC T00578 XX ID T00578 XX DT 15.10.92 (created); ewi. XX FA NF III-a XX SY NFIII-a; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (Jurkat) XX BS R00933; HS$IL2_04; Quality: 6; human, Homo sapiens XX RN [1] RA Brunvand M. W., Schmidt A., Siebenlist U. RT Nuclear Factors Interacting with the Mitogen-responsive RT Regulatory Region of the Interleukin-2 Gene RL J. Biol. Chem. 263:18904-18910 (1988). XX // AC T00579 XX ID T00579 XX DT 15.10.92 (created); ewi. XX FA NF III-c XX SY NFIII-c; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (Jurkat) XX BS R00935; HS$IL2_06; Quality: 6; human, Homo sapiens XX RN [1] RA Brunvand M. W., Schmidt A., Siebenlist U. RT Nuclear Factors Interacting with the Mitogen-responsive RT Regulatory Region of the Interleukin-2 Gene RL J. Biol. Chem. 263:18904-18910 (1988). XX // AC T00580 XX ID T00580 XX DT 15.10.92 (created); ewi. XX FA NF III-e XX SY NFIII-e; NFIL-2A; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (Jurkat) XX BS R00937; HS$IL2_08; Quality: 6; human, Homo sapiens XX RN [1] RA Brunvand M. W., Schmidt A., Siebenlist U. RT Nuclear Factors Interacting with the Mitogen-responsive RT Regulatory Region of the Interleukin-2 Gene RL J. Biol. Chem. 263:18904-18910 (1988). XX // AC T00581 XX ID T00581 XX DT 26.01.93 (created); hse. DT 23.06.97 (updated); ewi. XX FA C/EBPbeta XX SY AGP/EBP; ANF-2; CRP2; H-APF-2; IL-6DBP; LAP; LAP1; NF-IL6; NF-M; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0008; bZIP; 1.1.3.0.2.1. XX SZ 345 AA; 36.1 kDa (cDNA) XX SQ MQRLVAWDPACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGPRPPA SQ GELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAPPAPAPAPASSGQHHDFLSD SQ LFSDDYGGKNCKKPAEYGYVSLGRLGAAKGALHPGCFAPLHPPPPPPPPPAELKAEPGFE SQ PADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPSPAD SQ AKAPPTACYAGAGPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQ SQ HKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASSGHC XX SC SwissProt #P17676 XX FT 9 19 proline-rich region (7/11) FT 46 59 proline-rich region (7/14) FT 81 108 proline-rich region (9/28) FT 154 181 proline-rich region (13/28) FT 218 237 serine-rich region (10/14) FT 235 235 Thr-phosphorylation by MAP kinases [3]; FT 260 295 basic region FT 266 272 complex stabilizing subdomain [1]; FT 266 345 tryptic core domain within DNA complex [1]; FT 299 334 leucine zipper (TL5) FT 303 345 tryptic core domain XX SF very relaxed DNA-binding specificity, may even bind SF to AP-1 sites and may heterodimerize with either c-Fos or c-Jun [6]; SF the leucine zipper motif may also interact with the SF Rel-domain of NF-kappaB1 (p50) thus causing synergistic SF effects of both factors [5]; XX CP widespread; most abundant in spleen; liver, kidney after stimulation [8]; XX FF transcriptional activator in vitro and in vivo [8]; FF involved in acute phase reactions, inflammation and haematopoiesis; FF induced by IL-1, IL-6, LPS [8]; FF master regulator of the acute-phase response [8]; FF regulates constitutive as well as IL-1-induced transcription of IL-6 [8]; FF at the IL-6 promoter, it acts antagonistically to FF the p53 tumor suppressor [2]; FF protein is abundant in liver due to posttranscriptional regulation [8]; FF phosphorylation by p21(ras)-dependent MAP kinases FF enhances transcriptional activation [3]; FF trans-activation is repressed by association with c-Fos or c-Jun [6]; XX IN T00105; C/EBPalpha; human, Homo sapiens. IN T00108; C/EBPalpha; rat, Rattus norvegicus. IN T00109; C/EBPdelta; rat, Rattus norvegicus. IN T00123; c-Fos; human, Homo sapiens. IN T00127; CHOP-10; mouse, Mus musculus. IN T00133; c-Jun; human, Homo sapiens. IN T00583; C/EBPdelta; human, Homo sapiens. IN T00593; NF-kappaB1; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T01114; C/EBPdelta; mouse, Mus musculus. IN T01303; CREB-2; human, Homo sapiens. XX MX M00109; V$CEBPB_01 MX M00117; V$CEBPB_02 XX BS R00239; HS$CRP_03; Quality: 1; human, Homo sapiens BS R03136; HS$IL6_03; Quality: 1; human, Homo sapiens BS R02216; NFIL6$CONS; Quality: 6 BS R00111; RAT$ANTEN_01; Quality: 2; rat, Rattus norvegicus BS R03730; RAT$SAA1_02; Quality: 4; rat, Rattus norvegicus BS R03732; RAT$SAA1_04; Quality: 4; rat, Rattus norvegicus BS R03733; RAT$SAA1_05; Quality: 4; rat, Rattus norvegicus XX DR EMBL: X52560; HSNFIL6(g). DR SwissProt: P17676; CEBB_HUMAN. DR PIR: S12788; S12788. DR Compel: C00095 DR Compel: C00098 DR Compel: C00100 DR Compel: C00110 DR Compel: C00115 XX RN [1] RA Brasier A. R., Kumar A. RT Identification of a novel determinant for basic domain-leucine RT zipper DNA binding activity in the acute-phase inducible RT nuclear factor-interleukin-6 transcription factor RL J. Biol. Chem. 269:10341-10351 (1994). RN [2] RA Margulies L., Sehgal P. B. RT Modulation of the human interleukin-6 promoter (IL-6) RT and transcription factor C/EBPbeta (NF-IL-6) activity by p53 species RL J. Biol. Chem. 268:15096-15100 (1993). RN [3] RA Nakajima T., Kinoshita S., Sasagawa T., Sasaki K., RA Naruto M., Kishimoto T., Akira S. RT Phosphorylation at threonine-235 by ras-dependent RT mitogen-activated protein kinase cascade is essential RT for transcription factor NF-IL6 RL Proc. Natl. Acad. Sci. USA 90:2207-2211 (1993). RN [4] RA Isshiki H., Akira S., Tanabe O., Nakajima T., Shimamoto RA T., Hirano T., Kishimoto T. RT Constitutive and Interleukin-1 (IL-1)-Inducible Factors RT Interact with the IL-1-Responsive Element in the IL-6 Gene RL Mol. Cell. Biol. 10:2757-2764 (1990). RN [5] RA LeClair K. P., Blanar M. A., Sharp P. A. RT The p50 subunit of NF-kappaB associates with the NF-IL6 transcription factor RL Proc. Natl. Acad. Sci. USA 89:8145-8149 (1992). RN [6] RA Hsu W., Kerppola T. K., Chen P. L., Curran T., Chen-Kiang S. RT Fos and Jun repress transcription activation by NF-IL6 RT through association at the basic zipper region RL Mol. Cell. Biol. 14:268-276 (1994). RN [7] RA Isshiki H., Akira S., Sugita T., Nishio Y., Hashimoto RA S., Pawlowski T., Suematsu S., Kishimoto T. RT Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: RT possible involvement of NF-IL6 in acute phase protein gene expression RL New Biologist 3:63-70 (1991). RN [8] RA Akira S., Isshiki H., Sugita T., Tanabe O., Kinoshita RA S., Nishio Y., Nakajima T., Hirano T., Kishimoto T. RT A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family RL EMBO J. 9:1897-1906 (1990). XX // AC T00582 XX ID T00582 XX DT 15.10.92 (created); ewi. DT 23.06.93 (updated); ewi. XX FA NF-IL-2A XX SY NF IIE-e; NFIL-2A; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF activity, but not DNA-binding inhibited by CsA or FK-506 XX BS R00932; HS$IL2_03; Quality: 6; human, Homo sapiens BS R00936; HS$IL2_07; Quality: 6; human, Homo sapiens XX RN [1] RA Durand D. B., Shaw J.-P., Bush M. R., Replogle R. RA E., Belagaje R., Crabtree G. R. RT Characterization of Antigen Receptor Response Elements RT within the Interleukin-2 Enhancer RL Mol. Cell. Biol. 8:1715-1724 (1988). RN [2] RA Banerji S. S., Parsons J. N., Tocci M. J. RT The immunosuppressant FK-506 specifically inhibits RT mitogen-induced activation of the interleukin-2 promoter RT and the isolated enhancer elements NFIL-2A and NF-AT1 RL Mol. Cell. Biol. 11:4074-4087 (1991). XX // AC T00583 XX ID T00583 XX DT 23.03.93 (created); ewi. DT 23.06.97 (updated); ewi. XX FA C/EBPdelta XX SY CRP3; NF-IL6beta; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0008; bZIP; 1.1.3.0.4. XX SZ 269 AA; 28.4 kDa (cDNA) XX SQ MTAALFSLDGPAGGAPWPAEPAPFYEPGRAGKPGRGAEPGALGEPGAAAPAMYDDESAID SQ FSAYIDSMAAVPTLELCHDELFADLFNSNHKAGGAGPLELLPGGPARPLGPGPAAPRLLK SQ REPDWGDGDAPGSLLPAQVGPCAQTVVSLAAAGQPTPPTSPEPPRSSPRQTPAPGPAREK SQ SAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQL SQ TRDLAGLRQFFKQLPSPPFLPAAGTADCR XX SC translated from EMBL #M83667 XX FT 184 215 basic region FT 219 254 leucine zipper (ML5) XX SF same DNA-binding specificity as C/EBPbeta / NF-IL6 XX CP ubiquitous [3]; XX FF stronger transcriptional activator than C/BEPbeta; FF both can act synergistically [3]; FF undetectable levels in normal cells, but induced by FF LPS or inflammatory cytokines [3]; FF induction of C/EBPdelta (in contrast to C/EBPbeta) FF by IL-6 is at the transcriptional level [1]; XX IN T00017; C/EBPbeta; mouse, Mus musculus. IN T00105; C/EBPalpha; human, Homo sapiens. IN T00216; C/EBPgamma; mouse, Mus musculus. IN T00459; C/EBPbeta; rat, Rattus norvegicus. IN T00581; C/EBPbeta; human, Homo sapiens. IN T00583; C/EBPdelta; human, Homo sapiens. XX BS R03136; HS$IL6_03; Quality: 6; human, Homo sapiens BS R02216; NFIL6$CONS; Quality: 6 XX DR EMBL: M83667; HSNFIL6BA(g). DR EMBL: S63168; S63168(g). DR SwissProt: P49716; CEBD_HUMAN. XX RN [1] RA Ramji D. P., Vitelli A., Tronche F., Cortese R., Ciliberto G. RT The two C/EBP isoforms IL-6DBP/NF-IL6 and C/EBPgamma/NF-IL6beta RT are induced by IL-6 to promote acute phase gene transcription RT via different mechanisms RL Nucleic Acids Res. 21:289- 294 (1993). RN [2] RA Cleutjens C. B., van Eekelen C. C., van Dekken H., RA Smit E. M., Hagemeijer A., Wagner M. J., Wells D. E., Trapman J. RT The human C/EBP delta ( CRP3/CELF ) gene: structure RT and chromosomal localization RL Genomics 16:520-523 (1993). RN [3] RA Kinoshita S., Akira S., Kishimoto T. RT A member of the C/EBP family, NF-IL6beta, forms a RT heterodimer and transcriptionally synergizes with NF-IL6 RL Proc. Natl. Acad. Sci. USA 89:1473-1476 (1992). XX // AC T00584 XX ID T00584 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA NF-InsE1 XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX HO NF-muE1 XX BS R00910; RAT$INS1_06; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Moss L. G., Moss J. B., Rutter W. J. RT Systematic Binding Analysis of the Insulin Gene Transcription RT Control Region: Insulin and Immunoglobulin Enhancers RT Utilize Similar Transactivators RL Mol. Cell. Biol. 8:2620-2627 (1988). XX // AC T00585 XX ID T00585 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA NF-InsE2 XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX HO NF-muE2 XX BS R00991; AD$MLP_06; Quality: 6; adenovirus BS R00910; RAT$INS1_06; Quality: 6; rat, Rattus norvegicus BS R00902; RAT$INS_05; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Moss L. G., Moss J. B., Rutter W. J. RT Systematic Binding Analysis of the Insulin Gene Transcription RT Control Region: Insulin and Immunoglobulin Enhancers RT Utilize Similar Transactivators RL Mol. Cell. Biol. 8:2620-2627 (1988). XX // AC T00586 XX ID T00586 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA NF-InsE3 XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX HO NF-muE3 XX BS R00991; AD$MLP_06; Quality: 6; adenovirus BS R00910; RAT$INS1_06; Quality: 6; rat, Rattus norvegicus BS R00902; RAT$INS_05; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Moss L. G., Moss J. B., Rutter W. J. RT Systematic Binding Analysis of the Insulin Gene Transcription RT Control Region: Insulin and Immunoglobulin Enhancers RT Utilize Similar Transactivators RL Mol. Cell. Biol. 8:2620-2627 (1988). XX // AC T00587 XX ID T00587 XX DT 26.01.93 (created); hse. DT 01.11.94 (updated); hwi; ewi. XX FA NF-kappaB XX SY NF-kappaB complex; p50/p65; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0020; Rel; 4.1.1.0.3.1. XX SZ 50+65 kDa (SDS) XX IN T00168; c-Rel; human, Homo sapiens. IN T00414; IkappaB-beta; human, Homo sapiens. IN T00416; IkappaB-beta; chick, Gallus gallus. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00950; IkappaB-alpha; human, Homo sapiens. IN T00971; IkappaB-beta; mouse, Mus musculus. XX MX M00054; V$NFKAPPAB_01 MX M00208; V$NFKB_C XX BS R02217; NFKB$CONS; Quality: 6 BS R00112; RAT$ANTEN_02; Quality: 5; rat, Rattus norvegicus XX DR EMBL: L26267; RNNFKB(r). DR Compel: C00054 XX RN [1] RA Shirakawa F., Chedid M., Suttles J., Pollok B. A., Mizel S. B. RT Interleukin 1 and Cyclic AMP Induce k Immunoglobulin RT Light-Chain Expression vis Activation of an NF-kB-Like DNA-Binding Protein RL Mol. Cell. Biol. 9:959-964 (1989). RN [2] RA Gilmore T. D. RT NF-kappaB, KBF1, dorsal, and related matters RL Cell 62:841-843 (1990). RN [3] RA Lewin B. RT Oncogenic conversion by regulatory changes in transcription factors RL Cell 64:303-312 (1991). RN [4] RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially RT expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [5] RA Ballard D. W., Walker W. H., Doerre S., Sista P., RA Molitor J. A., Dixon E. P., Peffer N. J., Hannik M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding RT protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). RN [6] RA Nolan G. P., Gosh S., Liou H.-C., Tempst P., Baltimore D. RT DNA binding and IkappaB inhibition of the cloned p65 RT subunit of NF-kappaB, a rel-related polypeptide RL Cell 64:961-969 (1991). RN [7] RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [8] RA Baldwin A. S., Azizkhan J. C., Jensen D. E., Beg A. A., Coodly L. R. RT Induction of NF-kappaB DNA-binding activity during RT G0-to-G1 transition in mouse fibroblasts RL Mol. Cell. Biol. 11:4943-4951 (1991). XX // AC T00588 XX ID T00588 XX DT 15.10.92 (created); ewi. DT 04.11.96 (updated); ewi. XX FA NF-kappaB XX SY NF-kappaB complex; p50/p65; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0020; Rel; . XX SZ 50+65 kDa XX SF constituent complexes may be p50 homodimers or heterodimers SF of p50/p65, p50/RelB, or p50/c-Rel [8], [9], [11]; XX FF inducible activator, induced by many agents: e. g., FF TNF [14], PKA- or PKC-mediated signals, dsRNA [7], FF [2], [20], [15], [4], [6]; XX IN T00168; c-Rel; human, Homo sapiens. IN T00414; IkappaB-beta; human, Homo sapiens. IN T00416; IkappaB-beta; chick, Gallus gallus. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00950; IkappaB-alpha; human, Homo sapiens. IN T00971; IkappaB-beta; mouse, Mus musculus. XX MX M00054; V$NFKAPPAB_01 MX M00208; V$NFKB_C XX BS R02668; AS$NFKB_02; Quality: 6 BS R00699; HIV1$HIV1_06; Quality: 3; HIV-1, human immunodeficiency virus type 1 BS R00877; MOUSE$IGKL_01; Quality: 4; mouse, Mus musculus BS R01058; MOUSE$M1H2KB_06; Quality: 2; mouse, Mus musculus BS R01060; MOUSE$M1H2KB_08; Quality: 4; mouse, Mus musculus BS R01071; MOUSE$M2EAD_01; Quality: 4; mouse, Mus musculus BS R01448; MOUSE$TNFA_02; Quality: 4; mouse, Mus musculus BS R02217; NFKB$CONS; Quality: 6 BS R01887; RABBIT$IGKL_01; Quality: 4; rabbit, Oryctolagus cuniculus XX RN [1] RA Blanar M. A., Burkly L. C., Flavell R. A. RT NF-kB Binds within a Region Required for B-Cell-Specific RT Expression of the Major Histocompatibility Complex Class II Gene E RL Mol. Cell. Biol. 9:844-846 (1989). RN [2] RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB RT transcription factor involves dissociation of an apparently RT cytoplasmic NF-kappaB/inhibitor complex RL Cold Spring Harbor Symp. Quant. Biol. 53:789-798 (1989). RN [3] RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB RT catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 9:2424-2430 (1989). RN [4] RA Grilli M., Chiu J. J.-S., Lenardo M. J. RT NF-kappaB and Rel: Participants in a multiform transcriptional RT regulatory system RL Int. Rev. Cytol. 143:1-62 (1993). RN [5] RA Zhang Q., Didonato J. A., Karin M., McKeithan T. W. RT BCL3 encodes a nuclear protein which can alter the RT subcellular location of NF-kappaB proteins RL Mol. Cell. Biol. 14:3915-3926 (1994). RN [6] RA Diaz-Meco M. T., Berra E., Municio M. M., Sanz L., RA Lozano J., Dominguez I., Diaz-Golpe V., Lain De Lera RA M. T., Alcami J., Paya C. V., Arenzana-Seisdedos F., RA Virelizier J.-L., Moscat J. RT A dominant negative protein kinase C zeta subspecies RT blocks NF- kappaB activation RL Mol. Cell. Biol. 13:4770-4775 (1993). RN [7] RA Sen R., Baltimore D. RT Inducibility of kappa immunoglobulin enhancer-binding RT protein NF-kappaB by a posttranslational mechanism RL Cell 47:921-928 (1986). RN [8] RA Fujita T., Nolan G. P., Ghosh S., Baltimore D. RT Independent modes of transcriptional activation by RT the p50 and p65 subunits of NF-kappaB RL Genes Dev. 6:775-787 (1992). RN [9] RA Lernbecher T., Mueller U., Wirth T. RT Distinct NF-kappaB/Rel transcription factors are responsible RT for tissue-specific and inducible gene activation RL Nature 365:767-770 (1993). RN [10] RA Klug C. A., Gerety S. J., Shah P. C., Chen Y.-Y., RA Rice N. R., Rosenberg N., Singh H. RT The v-abl tyrosine kinase negatively regulates NF-kappaB/Rel RT factors and blocks kappa gene transcription in pre-B lymphocytes RL Genes Dev. 8:678-687 (1994). RN [11] RA Miyamoto S., Schmitt M. J., Verma I. M. RT Qualitative changes in the subunit composition of RT kappa-binding complexes during murine B-cell differentiation RL Proc. Natl. Acad. Sci. USA 91:5056-5060 (1994). RN [12] RA Shimizu H., Mitomo K., Watanabe T., Okamoto S., Yamamoto K.-I. RT Involvment of a NK-kB-Like Transcription Factor in RT the Activation of the Interleukin-6 Gene by Inflammatory Lymphokines RL Mol. Cell. Biol. 10:561-568 (1990). RN [13] RA Hagman J., Rudin Ch. M., Haasch D., Chaplin D., Storb U. RT A novel enhancer in the immunoglobulin lambda locus RT is duplicated and functionally independent of NFkB RL Genes Dev. 4:987-992 (1990). RN [14] RA Hohmann H.-P., Brockhaus M., Baeuerle P. A., Remy RA R., Kolbeck R., van Loon A. P. G. M. RT Expression of the types A and B tumor necrosis factor RT (TNF) receptors is independently regulated, and both RT receptors mediate activation of the transcription factor NF-kappaB RL J. Biol. Chem. 265:22409-22417 (1990). RN [15] RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB RT catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 11:2424-2430 (1991). RN [16] RA Logeat F., Israel N., Ten R., Blank V., Le Bail O., Kourilsky P., Israel A. RT Inhibition of transcription factors belonging to the RT rel/NF-kappaB family by a transdominant negative mutant RL EMBO J. 10:1827-1832 (1991). RN [17] RA Hromas R., Pauli U., Marcuzzi A., Lafrenz D., Nick RA H., Stein J., Stein G., Van Ness B. RT Inducible DNA-protein interactions of the murine kappa RT immunoglobulin enhancer in intact cells: comparison RT with in vitro interactions RL Nucleic Acids Res. 16:953-967 (1988). RN [18] RA Atchison M. L., Perry R. P. RT The Role of the kappa Enhancer and Its Binding Factor RT NF-kB in the Developmental Regulation of kappa Gene Transcription RL Cell 48:121-128 (1987). RN [19] RA Ghosh S., Baltimore D. RT Activation in vitro of NF-kappaB by phosphorylation of its inhibitor IkappaB RL Nature 344:678-682 (1990). RN [20] RA Shirakawa F., Chedid M., Suttles J., Pollok B. A., Mizel S. B. RT Interleukin 1 and Cyclic AMP Induce k Immunoglobulin RT Light-Chain Expression vis Activation of an NF-kB-Like DNA-Binding Protein RL Mol. Cell. Biol. 9:959-964 (1989). RN [21] RA Wirth T., Baltimore D. RT Nuclear factor NF-kB can interact functionally with RT its cognate binding site to provide lymphoid-specific promoter function RL EMBO J. 7:3109-3113 (1988). RN [22] RA Lenardo M. J., Fan C.-M., Maniatis T., Baltimore D. RT The Involvement of NF-kB in beta-Interferon Gene Regulation RT Reveals Its Role as Widely Inducible Mediator of Signal Transduction RL Cell 57:287-294 (1989). RN [23] RA Briskin M., Kuwabara M. D., Sigman D. S., Wall R. RT Induction of kappa transcription by interferon-gamma RT without activation of NF-kappaB RL Science 242:1036-1037 (1988). RN [24] RA Baeuerle P. A., Baltimore D. RT Activation of DNA-Binding Activity in an Apparently RT Cytoplasmic Precursor of the NF-kB Transcription Factor RL Cell 53:211-217 (1988). RN [25] RA Gilmore T. D. RT NF-kappaB, KBF1, dorsal, and related matters RL Cell 62:841-843 (1990). RN [26] RA Lewin B. RT Oncogenic conversion by regulatory changes in transcription factors RL Cell 64:303-312 (1991). RN [27] RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially RT expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [28] RA Ballard D. W., Walker W. H., Doerre S., Sista P., RA Molitor J. A., Dixon E. P., Peffer N. J., Hannik M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding RT protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). RN [29] RA Nolan G. P., Gosh S., Liou H.-C., Tempst P., Baltimore D. RT DNA binding and IkappaB inhibition of the cloned p65 RT subunit of NF-kappaB, a rel-related polypeptide RL Cell 64:961-969 (1991). RN [30] RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [31] RA Baldwin A. S., Azizkhan J. C., Jensen D. E., Beg A. A., Coodly L. R. RT Induction of NF-kappaB DNA-binding activity during RT G0-to-G1 transition in mouse fibroblasts RL Mol. Cell. Biol. 11:4943-4951 (1991). XX // AC T00590 XX ID T00590 XX DT 15.10.92 (created); ewi. DT 04.11.96 (updated); ewi. XX FA NF-kappaB XX SY NF-kappaB complex; p50/p65; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO TC-IIA XX CL C0020; Rel; . XX SZ 50 + 65 kDa (SDS) XX SQ MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRY SQ VCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCE SQ DGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQ SQ AEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAI SQ YDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGD SQ FSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEV SQ QRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITF SQ HPGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNG SQ EVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQ SQ DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE SQ DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAM SQ MSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDG SQ TTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMA SQ TSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKL SQ GLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTS SQ QAHSLPLSPASTRQQIDELRDSDSVCDTGVETSFRKLSFTESLTSGASLLTLNKMPHDYG SQ QEGPLEGKI XX SC SwissProt #P19838 XX SF Zn2+-dependent DNA-binding [16]; SF described as DNA-binding activity, constituted either SF by a p50 homodimer, a p50/p65 heterodimer (or related SF components), or a heterotetramer XX CP ubiquitous XX FF inducible activator, induced by many agents: e. g., FF TNF [32], PKA- or PKC-mediated signals, dsRNA [26], FF [15], [14], [40], [31], [21]; FF key regulator of genes involved in responses to infection, FF inflammation, stress [28]; FF reduced activity under oxidizing conditions by reactive FF oxygen intermediates (ROI) [20]; FF a CD28 receptor - tyrosine kinase - PLA2 - 5-lipoxygenase FF - ROI pathway activates NF-kappaB activity in certain T cells [29]; FF TNF-signalling may involve a phosphatidylcholine-specific FF PLC and subsequent sphingomyelin breakdown [24]; XX IN T00168; c-Rel; human, Homo sapiens. IN T00414; IkappaB-beta; human, Homo sapiens. IN T00416; IkappaB-beta; chick, Gallus gallus. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00950; IkappaB-alpha; human, Homo sapiens. IN T00971; IkappaB-beta; mouse, Mus musculus. XX MX M00054; V$NFKAPPAB_01 MX M00208; V$NFKB_C XX BS R02915; AS$NFKB_03; Quality: 6 BS R02916; AS$NFKB_04; Quality: 6 BS R00806; HCMV$IE1_20; Quality: 4; hCMV, human cytomegalovirus BS R00808; HCMV$IE1_22; Quality: 4; hCMV, human cytomegalovirus BS R00700; HIV1$HIV1_07; Quality: 4; HIV-1, human immunodeficiency virus type 1 BS R00701; HIV1$HIV1_08; Quality: 2; HIV-1, human immunodeficiency virus type 1 BS R00703; HIV1$HIV1_10; Quality: 2; HIV-1, human immunodeficiency virus type 1 BS R00704; HIV1$HIV1_11; Quality: 4; HIV-1, human immunodeficiency virus type 1 BS R03275; HS$ELAM1_01; Quality: 3; human, Homo sapiens BS R03340; HS$GROA_01; Quality: 5; human, Homo sapiens BS R03341; HS$GROB_01; Quality: 5; human, Homo sapiens BS R03342; HS$GROG_01; Quality: 5; human, Homo sapiens BS R00923; HS$IFNB_08; Quality: 2; human, Homo sapiens BS R00940; HS$IL2RA_01; Quality: 5; human, Homo sapiens BS R00942; HS$IL2RA_03; Quality: 5; human, Homo sapiens BS R00943; HS$IL2RA_04; Quality: 1; human, Homo sapiens BS R00933; HS$IL2_04; Quality: 4; human, Homo sapiens BS R00935; HS$IL2_06; Quality: 5; human, Homo sapiens BS R01634; HS$IL6_01; Quality: 1; human, Homo sapiens BS R02923; HS$TNFB_01; Quality: 4; human, Homo sapiens BS R00605; MOUSE$GMCSF_01; Quality: 2; mouse, Mus musculus BS R00606; MOUSE$GMCSF_02; Quality: 2; mouse, Mus musculus BS R00877; MOUSE$IGKL_01; Quality: 4; mouse, Mus musculus BS R02951; MOUSE$IL2_03; Quality: 1; mouse, Mus musculus BS R01056; MOUSE$M1H2KB_04; Quality: 2; mouse, Mus musculus BS R01058; MOUSE$M1H2KB_06; Quality: 2; mouse, Mus musculus BS R01060; MOUSE$M1H2KB_08; Quality: 4; mouse, Mus musculus BS R04397; MOUSE$P53_06; Quality: 6; mouse, Mus musculus BS R02217; NFKB$CONS; Quality: 6 BS R03733; RAT$SAA1_05; Quality: 4; rat, Rattus norvegicus BS R01406; SV$SV40_38; Quality: 4; SV40, simian virus 40 XX DR EMBL: M58603; HSNFKB(r). DR EMBL: M55643; HSNFKB34(r). DR EMBL: L01459; HSNFKBX(g). DR SwissProt: P19838; KBF1_HUMAN. DR PIR: A35696; A35696. DR Compel: C00055 DR Compel: C00056 DR Compel: C00057 DR Compel: C00058 DR Compel: C00059 DR Compel: C00060 DR Compel: C00061 DR Compel: C00062 DR Compel: C00097 DR Compel: C00098 DR Compel: C00099 DR Compel: C00100 DR Compel: C00101 DR Compel: C00102 DR Compel: C00103 DR Compel: C00140 XX RN [1] RA Visvanathan K. V., Goodbourn S. RT Double-stranded RNA activates binding of NF-kB to RT an inducible element in the human beta-interferon promoter RL EMBO J. 8:1129-1138 (1989). RN [2] RA Ballard D. W., Boehnlein E., Lowenthal J. W., Wano RA Y., Franza B. R., Greene W. C. RT HTLV-I Tax Induces Cellular Proteins That Activate RT the kB Element in the IL-2 Receptor alpha Gene RL Science 241:1652-1655 (1988). RN [3] RA Ruben S., Poteat H., Tan T.-H., Kawakami K., Roeder RA R., Haseltine W., Rosen C. A. RT Cellular Transcription Factors and Regulation of IL-2 RT Receptor Gene Expression by HTLV-I tax Gene Product RL Science 241:89-92 (1988). RN [4] RA Lowenthal J. W., Boehnlein E., Ballard D. W., Greene W. C. RT Regulation of interleukin 2 receptor alpha subunit RT (Tac of CD25 antigen) gene expression: Binding of RT inducible nuclear proteins to discrete promoter sequences RT correlates with transcriptional activation RL Proc. Natl. Acad. Sci. USA 85:4468-4472 (1988). RN [5] RA Leung K., Nabel G. J. RT HTLV-1 transactivator induces interleukin-2 receptor RT expression through an NF-kB-like factor RL Nature 333:776-778 (1988). RN [6] RA Cross S. L., Halden N. F., Lenardo M. J., Leonard W. J. RT Functionally Distinct NF-kB Binding Sites in the Immunoglobulin RT k and IL-2 Receptor alpha Chain Genes RL Science 244:466-469 (1989). RN [7] RA Edbrooke M. R., Burt D. W., Cheshire J. K., Woo P. RT Identification of cis-Acting Sequences Responsible RT for Phorbol Ester Induction of Human Serum A Gene RT Expression via a Nuclear Factor kB-Like Transcription Factor RL Mol. Cell. Biol. 9:1908-1916 (1989). RN [8] RA Kunsch C., Ruben S. M., Rosen C. A. RT Selection of optimal kappaB/Rel DNA-binding motifs: RT interaction of both subunits of NF-kappaB with DNA RT is required for transcriptional activation RL Mol. Cell. Biol. 12:4412-4421 (1992). RN [9] RA Zhang Y., Lin J.-X., Vilcek J. RT Interleukin-6 induction by tumor necrosis factor and RT interleukin-1 in human fibroblasts involves activation RT of a nuclear factor binding to a kappaB-like sequence RL Mol. Cell. Biol. 10:3818-3823 (1990). RN [10] RA Libermann T. A., Baltimore D. RT Activation of interleukin-6 gene expression through RT the NF-kappaB transcription factor RL Mol. Cell. Biol. 10:2327-2334 (1990). RN [11] RA Urban M. B., Baeuerle P. A. RT The 65-kD subunit of NF-kappaB is a receptor for IkappaB RT and a modulator of DNA-binding specificity RL Genes Dev. 4:1975-1984 (1990). RN [12] RA Schmitz M. L., Baeuerle P. A. RT The p65 subunit is responsible for the strong transcription RT activating potential of NF-kappaB RL EMBO J. 10:3805-3817 (1991). RN [13] RA Lenardo M. J., Fan C.-M., Maniatis T., Baltimore D. RT The involvement of NF-kappaB in beta-interferon gene RT regulation reveals its role as a widely inducible RT mediator of signal transduction RL Cell 57:287-294 (1989). RN [14] RA Visvanathan K. V., Goodbourn S. RT Double-stranded RNA activates binding of NF-kappaB RT to an inducible element in the human beta-interferon promoter RL EMBO J. 8:1129-1138 (1989). RN [15] RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB RT transcription factor involves dissociation of an apparently RT cytoplasmic NF-kappaB/inhibitor complex RL Cold Spring Harbor Symp. Quant. Biol. 53:789-798 (1989). RN [16] RA Zabel U., Schreck R., Baeuerle P. A. RT DNA binding of purified transcription factor NF-kappaB RL J. Biol. Chem. 266:252-260 (1991). RN [17] RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially RT expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [18] RA Bachelerie F., Alcami J., Arenzana-Seisdedos F., Virelizier J.-L. RT HIV enhancer activity perpetuated by NF-kappaB induction RT on infection of monocytes RL Nature 350:709-712 (1991). RN [19] RA Riviere Y., Blank V., Kourilsky P., Israel A. RT Processing of the precursor of NF-kappaB by the HIV-1 RT protease during acute infection RL Nature 350:625-626 (1991). RN [20] RA Schreck R., Rieber P., Baeuerle P. A. RT Reactive oxygen intermediates as apparently widely RT used messengers in the activation of the NF-kappaB RT transcription factor and HIV-1 RL EMBO J. 10:2247-2258 (1991). RN [21] RA Grilli M., Chiu J. J.-S., Lenardo M. J. RT NF-kappaB and Rel: Participants in a multiform transcriptional RT regulatory system RL Int. Rev. Cytol. 143:1-62 (1993). RN [22] RA Pan J., McEver R. P. RT Regulation of the human P-selection promoter by Bcl-3 RT and specific homodimeric members of the NF-kappaB/Rel family RL J. Biol. Chem. 270:23077-23083 (1995). RN [23] RA Rothe M., Sarma V., Dixit V. M., Goeddel D. V. RT TRAF2-mediated activation of NF-kappaB by TNF receptor 2 and CD40 RL Science 269:1424-1427 (1995). RN [24] RA Schuetze S., Potthoff K., Machleidt T., Berkovic D., Wiegmann K., Kroenke M. RT TNF activates NF-kappaB by phosphatidylcholine-specific RT phospholipase C-induced 'acidic' sphingomyelin breakdown RL Cell 71:765-776 (1992). RN [25] RA Naumann M., Scheidereit C. RT Activation of NF-6B in vivo is regulated by multiple phosphorylations RL EMBO J. 13:4597-4607 (1994). RN [26] RA Sen R., Baltimore D. RT Inducibility of kappa immunoglobulin enhancer-binding RT protein NF-kappaB by a posttranslational mechanism RL Cell 47:921-928 (1986). RN [27] RA Schenk H., Klein M., Erdbruegger W., Droege W., Schulze-Osthoff K. RT Distinct effects of thioredoxin and antioxidants on RT the activation of transcription factors NF-kappaB and AP-1 RL Proc. Natl. Acad. Sci. USA 91:1672-1676 (1994). RN [28] RA Baeuerle P. A., Henkel T. A. RT Function and activation of NF-kappa B in the immune system RL Rev. Immun. 12:141-179 (1994). RN [29] RA Los M., Schenk H., Hexel K., Baeuerle P. A., Droege W., Schulz-Osthoff K. RT IL-2 gene expression and NF-kappaB activation through RT CD28 requires reactive oxygen production by 5-lipoxygenase RL EMBO J. 14:3731-3740 (1995). RN [30] RA Stein B., Rahmsdorf H. J., Steffen A., Litfin M., Herrlich P. RT UV-Induced DNA Damage Is an Intermediate Step in UV-Induced RT Expression of Human Immunodeficiency Virus Type 1 RT Collagenase, c-fos and Metallothionein RL Mol. Cell. Biol. 9:5169-5181 (1989). RN [31] RA Duh E. J., Maury W. J., Folks T. M., Fauci A. S., Rabson A. B. RT Tumor necrosis factor alpha activates human immunodeficiency RT virus type 1 through induction of nuclear factor binding RT to the NF-kB sites in the long terminal repeat RL Proc. Natl. Acad. Sci. USA 86:5974-5978 (1989). RN [32] RA Hohmann H.-P., Brockhaus M., Baeuerle P. A., Remy RA R., Kolbeck R., van Loon A. P. G. M. RT Expression of the types A and B tumor necrosis factor RT (TNF) receptors is independently regulated, and both RT receptors mediate activation of the transcription factor NF-kappaB RL J. Biol. Chem. 265:22409-22417 (1990). RN [33] RA Franza Jr. B. R., Josephs S. F., Gilman M. Z., Ryan W., Clarkson B. RT Characterization of cellular proteins recognizing RT the HIV enhancer using a microscale DNA-affinity precipitation assay RL Nature 330:391-395 (1987). RN [34] RA Dinter H., Chiu R., Imagawa M., Karin M., Jones K. A. RT in vitro activation of the HIV-1 enhancer in extracts RT from cells treated with a phorbol ester tumor promoter RL EMBO J. 6:4067-4071 (1987). RN [35] RA Kawakami K., Scheidereit C., Roeder R. G. RT Identification and purification of a human immunoglobulin-enhancer-binding RT protein (NF-kappaB) that activates transcription from RT a human immunodeficiency virus type 1 promoter in vitro RL Proc. Natl. Acad. Sci. USA 85:4700-4704 (1988). RN [36] RA Gaynor R. B., Kuwabara M. D., Wu F. K., Garcia J. RA A., Harrich D., Briskin M., Wall R., Sigman D. S. RT Repeated B motifs in the human immunodeficiency virus RT type I long terminal repeat enhancer region do not RT exhibit cooperative factor binding RL Proc. Natl. Acad. Sci. USA 85:9406-9410 (1988). RN [37] RA Osborn L., Kunkel S., Nabel G. J. RT Tumor necrosis factor alpha and interleukin 1 stimulate RT the human immunodeficiency virus enhancer by activation RT of the nuclear factor kB RL Proc. Natl. Acad. Sci. USA 86:2336-2340 (1989). RN [38] RA Hoyos B., Ballard D. W., Boehnlein E., Siekevitz M., Greene W. C. RT Kappa B-Specific DNA Binding Proteins: Role in the RT Regulation of Human Interleukin-2 Gene Expression RL Science 244:457-460 (1989). RN [39] RA Toledano M. B., Leonard W. J. RT Modulation of transcription factor NF-kappaB binding RT activity by oxidation-reduction in vitro RL Proc. Natl. Acad. Sci. USA 88:4328-4332 (1991). RN [40] RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB RT catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 11:2424-2430 (1991). RN [41] RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). RN [42] RA Lenardo M. J., Fan C.-M., Maniatis T., Baltimore D. RT The Involvement of NF-kB in beta-Interferon Gene Regulation RT Reveals Its Role as Widely Inducible Mediator of Signal Transduction RL Cell 57:287-294 (1989). RN [43] RA Baeuerle P. A., Baltimore D. RT Activation of DNA-Binding Activity in an Apparently RT Cytoplasmic Precursor of the NF-kB Transcription Factor RL Cell 53:211-217 (1988). RN [44] RA Baeuerle P., Baltimore D. RT A 65-kD subunit of active NF-kappaB is required for RT inhibition of NF-kappaB by IkappaB RL Genes Dev. 3:1689-1698 (1989). RN [45] RA Gilmore T. D. RT NF-kappaB, KBF1, dorsal, and related matters RL Cell 62:841-843 (1990). RN [46] RA Lewin B. RT Oncogenic conversion by regulatory changes in transcription factors RL Cell 64:303-312 (1991). RN [47] RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially RT expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [48] RA Ballard D. W., Walker W. H., Doerre S., Sista P., RA Molitor J. A., Dixon E. P., Peffer N. J., Hannik M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding RT protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). RN [49] RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [50] RA Clark L., Pollock R. M., Hay R. T. RT Identification and purification of EBP1: a HeLa cell RT protein that binds to a region overlapping the core of the SV40 enhancer RL Genes Dev. 2:991-1002 (1988). XX // AC T00591 XX ID T00591 XX DT 15.10.92 (created); ewi. DT 30.03.94 (updated); hwi. XX FA NF-kappaB(-like) XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 36-42 kDa (4 peptides) XX BS R02913; AD$E3_09; Quality: 5; adenovirus BS R02914; AD$E3_10; Quality: 5; adenovirus BS R02909; HS$IL8_02; Quality: 5; human, Homo sapiens BS R01349; HS$SAA_01; Quality: 5; human, Homo sapiens BS R02463; MOUSE$CBF_01; Quality: 5; mouse, Mus musculus BS R02464; MOUSE$CC4_01; Quality: 5; mouse, Mus musculus BS R04128; MOUSE$PRP_01; Quality: 5; mouse, Mus musculus BS R02217; NFKB$CONS; Quality: 6 BS R02980; RAT$PK_01; Quality: 5; rat, Rattus norvegicus BS R01408; SV$SV40_40; Quality: 5; SV40, simian virus 40 XX RN [1] RA Nakamura M., Niki M., Nagata K., Ohtani K., Saito S., Hinuma Y., Sugamura K. RT Cell Line-dependent Response of the Enhancer Element RT of Simian Virus 40 to Transactivator p40tax Encoded RT by Human T-cell Leukemia Virus Type I RL J. Biol. Chem. 264:20189-20192 (1989). RN [2] RA Maekawa T., Itoh F., Okamoto T., Kurimoto M., Imamoto F., Ishii S. RT Identification and Purification of the Enhancer-binding RT Factor of Human Immunodeficiency Virus-1 RL J. Biol. Chem. 264:2826-2831 (1989). XX // AC T00592 XX ID T00592 XX DT 15.10.92 (created); ewi. XX FA NF-kappaB(-like) XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01936; HS$IL6_02; Quality: 5; human, Homo sapiens BS R01607; MOUSE$CMYC_03; Quality: 5; mouse, Mus musculus BS R01058; MOUSE$M1H2KB_06; Quality: 6; mouse, Mus musculus BS R01065; MOUSE$M1H2LD_03; Quality: 5; mouse, Mus musculus BS R02338; MOUSE$MHC2IN_01; Quality: 5; mouse, Mus musculus BS R04128; MOUSE$PRP_01; Quality: 5; mouse, Mus musculus BS R02217; NFKB$CONS; Quality: 6 XX RN [1] RA Duyao M. P., Buckler A. J., Sonenshein G. E. RT Interaction of an NF-kappaB-like factor with a site RT upstream of the c-myc promoter RL Proc. Natl. Acad. Sci. USA 87:4727-4731 (1990). XX // AC T00593 XX ID T00593 XX DT 15.10.92 (created); ewi. DT 04.11.96 (updated); ewi. XX FA NF-kappaB1 XX SY 243/NFA-kappaB; EBP-1; KBF1; NF-kappaB (p50); p110; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0020; Rel; 4.1.1.0.3.1. XX SZ 51 kDa, 57-63 kDa (SDS) XX FT 19 399 DNA-binding domain [35]; FT 62 62 cysteine important for DNA-binding [14]; FT 43 366 Rel homology region FT 362 366 RKRQK: nuclear localization signal FT 719 751 essential for cytoplasmic retention XX SF N-terminal half of a 105 kDa precursor (T01925) [3]; SF binding to DNA either as homodimer or as heteromer with RelA/p65 [31]; SF Cys-62 is part of a R(F/G)(R/K)YXCE motif found in SF also other Rel proteins as well as in zinc finger SF proteins that bind to kappaB sites SF it has to be reduced to enable DNA-binding [17], presumably SF by a nuclear thioredoxin system [14], [15], [16]; SF DNA-binding domain is largely non-helical [27], [19]; SF rather, the Rel domain comprises two beta-barrel domains SF the loops of which constitute an extensive DNA contacting surface [19]; SF there is a major groove-binding recognition loop within SF the N-terminal subdomain which resembles the p53 DNA-binding domain [19]; SF the C-terminal subdomain exhibits a beta-sandwich SF structure resembling immunoglobulins and is contacted by IkappaB [19]; SF though not being a primary target for IkappaB, the SF NLS of p50 is masked by the inhibitor in holo-NF-kappaB/IkappaB SF complexes [12]; SF the homodimer reveals a 10-fold higher affinity to SF symmetric sites than the p50/p65 heterodimer [31]; SF the heterodimer binds more avidly to asymmetric sites: KD = 0.4 pM [31]; SF binding to some kappaB sites (e. g., IFN-beta promoter) SF is significantly augmented by HMG I(Y) [8]; SF DNA-binding is sensitive towards CpG methylation [20]; SF reported zinc-dependence of DNA-binding is not yet SF explained by structural features [7]; SF the Rel domain interacts with the leucine zipper of SF C/EBPbeta [21], [24], and probably also of C/EBP alpha, SF -gamma-, and delta which also synergize with NF-kappaB [24]; SF Rel-ZIP interactions have also been suggested for SF p50 and ATF-a, CRE-BP1, ATF-3 [22]; SF the interaction of the Rel domain with the DNA-binding SF domain of ER inibits DNA-binding by p50 [18]; XX CP ubiquitous XX FF primary DNA-binding subunit of NF-kappaB; FF homodimers may repress transcription [2], [10], [25]; FF hyperposphorylation in the cytosol of T cells by a FF 43 kDa protein kinase which is associated with the FF NF-kappaB/IkappaB complex [26], [13]; FF phosphorylation of p50 may contribute to NF-kappaB FF activation by enhancing the DNA-binding capability [26]; FF upstream signal transducers may be Raf, Src, H-Ras, Mos [23]; XX IN T00052; ATF-a; human, Homo sapiens. IN T00167; CRE-BP1; human, Homo sapiens. IN T00168; c-Rel; human, Homo sapiens. IN T00169; c-Rel; mouse, Mus musculus. IN T00261; ER; human, Homo sapiens. IN T00394; NF-kappaB2; human, Homo sapiens. IN T00581; C/EBPbeta; human, Homo sapiens. IN T00593; NF-kappaB1; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T01154; c-Rel; chick, Gallus gallus. IN T01313; ATF-3; human, Homo sapiens. IN T01925; NF-kappaB1 precursor; human, Homo sapiens. IN T01927; NF-kappaB2 precursor; human, Homo sapiens. IN T01928; Bcl-3; human, Homo sapiens. IN T01943; IkappaBR; human, Homo sapiens. XX MX M00051; V$NFKAPPAB50_01 MX M00208; V$NFKB_C XX BS R01748; AS$NFKB_01; Quality: 2 BS R02921; AS$NFKB_05; Quality: 6 BS R00700; HIV1$HIV1_07; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R00923; HS$IFNB_08; Quality: 6; human, Homo sapiens BS R00943; HS$IL2RA_04; Quality: 6; human, Homo sapiens BS R00933; HS$IL2_04; Quality: 6; human, Homo sapiens BS R02189; KBF1$CONS; Quality: 6 BS R00879; MOUSE$IGKL_03; Quality: 6; mouse, Mus musculus BS R01744; MOUSE$IRF1_01; Quality: 6; mouse, Mus musculus BS R01058; MOUSE$M1H2KB_06; Quality: 6; mouse, Mus musculus BS R02217; NFKB$CONS; Quality: 6 XX DR EMBL: M55643; HSNFKB34(r). DR SwissProt: P19838; KBF1_HUMAN. DR PIR: A35696; A35696. XX RN [1] RA Blank V., Kourilsky P., Israel A. RT Cytoplasmic retention, DNA binding and processing RT of the NF--kappaB p50 precursor are controlled by RT a small region in its C-terminus RL EMBO J. 10:4159-4167 (1991). RN [2] RA Schmitz M. L., Baeuerle P. A. RT The p65 subunit is responsible for the strong transcription RT activating potential of NF-kappaB RL EMBO J. 10:3805-3817 (1991). RN [3] RA Bours V., Villalobos J., Burd P. R., Kelly K., Siebenlist U. RT Cloning of a mitogen-inducible gene encoding a kappaB RT DNA-binding protein with homology to the rel oncogene RT and to cell-cycle motifs RL Nature 348:76-80 (1990). RN [4] RA Kieran M., Blank V., Logeat F., Vendekerckhove J., RA Lottspeich F., Bail Le O., Urban M. B., Kourilsky P., Baeuerle P., Israel A. RT The DNA binding subunit of NF-kappaB is identical RT to factor KBF1 and homologous to the rel oncogene product RL Cell 62:1007-1018 (1990). RN [5] RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB RT transcription factor involves dissociation of an apparently RT cytoplasmic NF-kappaB/inhibitor complex RL Cold Spring Harbor Symp. Quant. Biol. 53:789-798 (1989). RN [6] RA Meyer R., Hatada E. N., Hohmann H.-P., Haiker M., RA Bartsch C., Roethlisberger U., Lahm H.-W., Schlaeger RA E. J., van Loon A. P. G. M., Scheidereit C. RT Cloning of the DNA-binding subunit of human nuclear RT factor kappaB: the level of its mRNA is strongly regulated RT by phorbol ester or tumor necrosis factor alpha RL Proc. Natl. Acad. Sci. USA 88:966-970 (1991). RN [7] RA Zabel U., Schreck R., Baeuerle P. A. RT DNA binding of purified transcription factor NF-kappaB RL J. Biol. Chem. 266:252-260 (1991). RN [8] RA Thanos D., Maniatis T. RT The high mobility group protein HMG I(Y) is required RT for NF-kappaB-dependent virus induction of the human IFN-beta gene RL Cell 71:777-789 (1992). RN [9] RA Riviere Y., Blank V., Kourilsky P., Israel A. RT Processing of the precursor of NF-kappaB by the HIV-1 RT protease during acute infection RL Nature 350:625-626 (1991). RN [10] RA Schmid R. M., Perkins N. D., Duckett C. S., Andrews P. C., Nabel G. J. RT Cloning of an NF-kappaB subunit which stimulates HIV RT transcription in synergy with p65 RL Nature 352:733-736 (1991). RN [11] RA Fan C.-M., Maniatis T. RT Generation of p50 subunit of NF-kappaB by processing RT of p105 through an ATP-dependent pathway RL Nature 354:395-398 (1991). RN [12] RA Zabel U., Henkel T., dos Santos Silva M., Baeuerle P. A. RT Nuclear uptake control of NF-kappaB by MAD-3, an IkappB RT protein present in the nucleus RL EMBO J. 12:201-211 (1993). RN [13] RA Hayashi T., Sekine T., Okamoto T. RT Identification of a new serine kinase that activates RT NFkappaB by direct phosphorylation RL J. Biol. Chem. 268:26790-26795 (1993). RN [14] RA Matthews J. R., Wakasugi N., Virelizier J. L., Yodoi J., Hay R. T. RT Thioredoxin regulates the DNA binding activity of RT NF-kappaB by reduction of a disulphide bond involving cysteine 62 RL Nucleic Acids Res. 20:3821-3830 (1992). RN [15] RA Matthews J. R., Kaszubska W., Turcatti G., Wells T. N. C., Hay R. T. RT Role of cysteine62 in DNA recognition by the P50 subunit of NF-kappaB RL Nucleic Acids Res. 21:1727-1734 (1993). RN [16] RA Hayashi T., Ueno Y., Okamoto T. RT Oxidoreductive regulation of Nuclear Factor kappa RT B (Involvement of a cellular reducing catalyst thioredoxin) RL J. Biol. Chem. 268:11380-11388 (1993). RN [17] RA Toledano M. B., Ghosh D., Trinh F., Leonard W. J. RT N-terminal DNA-Binding contribute to differential RT DNA-binding specifities of NF-kappaB p50 and p65 RL Mol. Cell. Biol. 13:852-860 (1993). RN [18] RA Stein B., Yang M. X. RT Repression of the interleukin-6 promoter by estrogen RT rceptor is mediated by NF-kappaB and C/EBPbeta RL Mol. Cell. Biol. 15:4971-4979 (1995). RN [19] RA Mueller C. W., Rey F. A., Sodeoka M., Verdine G. L., Harrison S. C. RT Structure of the NF-kappaB p50 homodimer bound to DNA RL Nature 373:311-317 (1995). RN [20] RA Bednarik D. P., Duckett C., Kim S. U., Perez V. L., RA Griffis K., Guenther P. C., Folks T. M. RT DNA CpG methylation inhibits binding of NF-kappaB RT proteins to the HIV-1 long terminal repeat cognate DNA motifs RL New Biologist 3:969-976 (1991). RN [21] RA LeClair K. P., Blanar M. A., Sharp P. A. RT The p50 subunit of NF-kappaB associates with the NF-IL6 transcription factor RL Proc. Natl. Acad. Sci. USA 89:8145-8149 (1992). RN [22] RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., RA DeRaemy-Schenk A.-M., Chen B. P. C., Hai T., DeLamarter J. F., Whelan J. RT Cyclic AMP-independent ATF family members interact RT with NF-kappaB and function in the activation of the RT E-selectin promoter in response to cytokines RL Mol. Cell. Biol. 13:7180-7190 (1993). RN [23] RA Devary Y., Rosette C., Didonato J. A., Karin M. RT NF-kappaB activation by ultraviolet light not dependent on a nuclear signal RL Science 261:1442-1445 (1993). RN [24] RA Stein B., Cogswell P. C., Baldwin A. S. RT Functional and physical associations between NF-kappaB RT and C/EBP family members: a Rel domain-bZIP interaction RL Mol. Cell. Biol. 13:3964-3974 (1993). RN [25] RA Plaksin D., Baeuerle P. A., Eisenbach L. RT KBF1 (p50 NF-kappaB homodimer) acts as a repressor RT of H-2Kb gene expression in metastatic tumor cells RL J. Exp. Med. 177:1651-1662 (1993). RN [26] RA Li C.-C., Dai R.-M., Chen E., Longo D. L. RT Phosphorylation of NF-KB1-p50 is involved in NF-kappaB RT activation and stable DNA binding RL J. Biol. Chem. 269:30089-30092 (1994). RN [27] RA Liu J., Sodeoka M., Lane W. S., Verdine G. L. RT Evidence for a non-alpha-helical DNA-binding motif RT in the Rel homology region RL Proc. Natl. Acad. Sci. USA 91:908-912 (1994). RN [28] RA Clark L., Matthews J. R., Hay R. T. RT Interaction of enhancer-binding protein EBP1 (NF-kappaB) RT with the human immunodeficiency virus type 1 enhancer RL J. Virol. 64:1335-1344 (1990). RN [29] RA Wu F. K., Garcia J. A., Harrich D., Gaynor R. B. RT Purification of the human immunodeficiency virus type RT 1 enhancer and TAR binding proteins EBP-1 and UBP-1 RL EMBO J. 7:2117-2129 (1988). RN [30] RA Clark L., Hay R. T. RT Sequence requirements for specific interaction of RT an enhancer binding protein (EBP1) with DNA RL Nucleic Acids Res. 17:499-516 (1989). RN [31] RA Urban M. B., Baeuerle P. A. RT The 65-kD subunit of NF-kappaB is a receptor for IkappaB RT and a modulator of DNA-binding specificity RL Genes Dev. 4:1975-1984 (1990). RN [32] RA Toledano M. B., Leonard W. J. RT Modulation of transcription factor NF-kappaB binding RT activity by oxidation-reduction in vitro RL Proc. Natl. Acad. Sci. USA 88:4328-4332 (1991). RN [33] RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB RT catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 11:2424-2430 (1991). RN [34] RA Gilmore T. D. RT NF-kappaB, KBF1, dorsal, and related matters RL Cell 62:841-843 (1990). RN [35] RA Kieran M., Blank V., Logeat F., Vandekerckhove J., RA Lottspeich F., Le Bail O., Urban M. B., Kourilsky RA P., Baeuerle B. A., Israel A. RT The DNA binding subunit of NF-kappaB is identical RT to factor KBF1 and homologous to the rel oncogene product RL Cell 62:1007-1018 (1990). RN [36] RA Lewin B. RT Oncogenic conversion by regulatory changes in transcription factors RL Cell 64:303-312 (1991). RN [37] RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially RT expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [38] RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [39] RA Clark L., Pollock R. M., Hay R. T. RT Identification and purification of EBP1: a HeLa cell RT protein that binds to a region overlapping the core of the SV40 enhancer RL Genes Dev. 2:991-1002 (1988). XX // AC T00594 XX ID T00594 XX DT 15.10.92 (created); ewi. DT 05.11.96 (updated); ewi. XX FA RelA XX SY NF-kappaB (p65); Rel-A; p65; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0020; Rel; . XX SZ 551 AA; 60.2 kDa (cDNA), 65 kDa (SDS) XX SQ MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT SQ IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC SQ VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLP SQ HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS SQ QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE SQ KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY SQ DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA SQ VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ SQ GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM SQ DFSALLSQISS XX SC SwissProt #Q04206 XX FT 19 304 Rel homology region FT 216 216 cysteine important for homodimerization [14]; FT 273 276 potential PKA site important for homodimerization [14]; FT 301 304 nuclear localization signal [19]; FT 521 551 trans-activation domain 1 (TA1) [3]; FT 428 521 trans-activation domain 2 (TA2) [3]; FT 458 483 trans-activation domain 1' (TA1') [3]; FT 168 189 proline-rich region (7/22) FT 317 350 proline-rich region (12/34) FT 381 428 proline-rich region (18/48) FT 222 231 important for multimerization and FT for DNA-binding, missing in p65delta FT 415 550 transcription activation domain [2]; XX SF four AA residues in the DNA-binding Rel domain mediate SF a distinct DNA-binding specificity of the RelA (p65) SF homodimer compared to heterodimers [15]; SF cytoplasmic inhibitors (IkappaB-alpha and -beta) bind SF to the Rel domain of RelA [30], [28] thus masking SF the nuclear localization signal [19], [7]; SF the splice variant p65delta cannot dimerize with itself SF or with p50, but with intact RelA [2], and interacts SF only weakly with IkappaB-alpha since dimerization SF is important for inhibitor binding [19]; SF the Rel domain of RelA interacts with leucine zipper SF structures of c-Fos, c-Jun [22], C/EBP-beta [12], SF and probably also ATF-a and CRE-BP1 [11]; SF it may also interact with the zinc finger domain of SF Sp1 [24] and the DNA-binding domain of the estrogen SF receptor (ER), independent of its ligand-bound status [9]; SF the potent trans-activating domain comprises several SF subdomains, of which TA2 contains another TA1-homologous SF region, both revealing a highly amphiphilic character SF when alpha-helically folded, with one side exclusively SF comprising serine residues [3]; SF moreover, the trans-activating domain contains several SF acidic modules with a critical core phenylalanine SF and flanking bulky hydrophobic residues [3]; XX CP ubiquitous XX FF contributes the major transcription activation domain FF to the NF-kappaB complex [4]; FF at some sequences, its homodimers may act as transcriptional FF activators [32], [5]; FF synergistic effects with AP-1 through AP-1 sites as FF wellas through kappaB sites (c-Fos and c-Jun, not JunB or JunD; FF also not found for NF-kappaB1) [22]; FF similar synergism with C/EBP family members [12] and FF with Sp1, e. g. at the HIV-1 LTR [16]; FF in T cells, RelA is phosphorylated by a 43 kDa protein FF kinase associated with the NF-kappaB/IkappaB complex [8]; FF subsequent release of RelA permits nuclear translocation [10]; FF PKC-mediated phosphorylation and trans-activation through TA2 [3]; FF constitutive phosphorylation of TA1 [3]; FF PKA-mediated phosphorylation decreases nuclear translocation FF of RelA, presumably by decreasing the rate of IkappaB degradation [18]; FF the splice variant p65delta suppresses NF-kappaB activity FF and exhibits transforming properties [21]; XX IN T00052; ATF-a; human, Homo sapiens. IN T00123; c-Fos; human, Homo sapiens. IN T00133; c-Jun; human, Homo sapiens. IN T00167; CRE-BP1; human, Homo sapiens. IN T00168; c-Rel; human, Homo sapiens. IN T00261; ER; human, Homo sapiens. IN T00394; NF-kappaB2; human, Homo sapiens. IN T00414; IkappaB-beta; human, Homo sapiens. IN T00416; IkappaB-beta; chick, Gallus gallus. IN T00581; C/EBPbeta; human, Homo sapiens. IN T00593; NF-kappaB1; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00950; IkappaB-alpha; human, Homo sapiens. IN T00971; IkappaB-beta; mouse, Mus musculus. IN T01523; p65delta; human, Homo sapiens. IN T01927; NF-kappaB2 precursor; human, Homo sapiens. IN T01929; NF-kappaB2 precursor; chick, Gallus gallus. IN T01930; NF-kappaB2 (p49); human, Homo sapiens. XX MX M00052; V$NFKAPPAB65_01 XX BS R02921; AS$NFKB_05; Quality: 6 BS R00923; HS$IFNB_08; Quality: 6; human, Homo sapiens BS R00943; HS$IL2RA_04; Quality: 6; human, Homo sapiens BS R00879; MOUSE$IGKL_03; Quality: 6; mouse, Mus musculus BS R01744; MOUSE$IRF1_01; Quality: 6; mouse, Mus musculus BS R01058; MOUSE$M1H2KB_06; Quality: 6; mouse, Mus musculus XX DR EMBL: L19067; HSNFKB65A(r). DR EMBL: L01459; HSNFKBX(g). DR EMBL: M62399; HSP50NFK(r). DR EMBL: Z22948; HSP65A(g). DR EMBL: Z22949; HSP65B(g). DR EMBL: Z22950; HSP65C(g). DR EMBL: Z22951; HSP65D(g). DR EMBL: Z22952; HSP65E(g). DR EMBL: Z22953; HSP65F(g). DR EMBL: Z22954; HSP65G(g). DR SwissProt: Q04206; TF65_HUMAN. DR PIR: A40851; A40851. XX RN [1] RA Kunsch C., Ruben S. M., Rosen C. A. RT Selection of optimal kappaB/Rel DNA-binding motifs: RT interaction of both subunits of NF-kappaB with DNA RT is required for transcriptional activation RL Mol. Cell. Biol. 12:4412-4421 (1992). RN [2] RA Ruben S. M., Narayanan R., Klement J. F., Chen C.-H., Rosen C. A. RT Functional characterization of the NF-kappaB p65 transcriptional RT activator and an alternatively spliced derivate RL Mol. Cell. Biol. 12:444-454 (1992). RN [3] RA Schmitz M. L., dos Santos Silva M. A., Baeuerle P. A. RT Transactivation domain 2 (TA2) of p65 NF-kappaB RL J. Biol. Chem. 270:15576-15584 (1995). RN [4] RA Schmitz M. L., Baeuerle P. A. RT The p65 subunit is responsible for the strong transcription RT activating potential of NF-kappaB RL EMBO J. 10:3805-3817 (1991). RN [5] RA Ruben S. M., Dillon P. J., Schreck R., Henkel T., RA Chen C.-H., Maher M., Baeuerle P. A., Rosen C. A. RT Isolation of a rel-related human cDNA that potentially RT encodes the p65-kD subunit of NF-kappaB RL Science 251:1490-1493 (1991). RN [6] RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB RT transcription factor involves dissociation of an apparently RT cytoplasmic NF-kappaB/inhibitor complex RL Cold Spring Harbor Symp. Quant. Biol. 53:789-798 (1989). RN [7] RA Zabel U., Henkel T., dos Santos Silva M., Baeuerle P. A. RT Nuclear uptake control of NF-kappaB by MAD-3, an IkappB RT protein present in the nucleus RL EMBO J. 12:201-211 (1993). RN [8] RA Hayashi T., Sekine T., Okamoto T. RT Identification of a new serine kinase that activates RT NFkappaB by direct phosphorylation RL J. Biol. Chem. 268:26790-26795 (1993). RN [9] RA Stein B., Yang M. X. RT Repression of the interleukin-6 promoter by estrogen RT rceptor is mediated by NF-kappaB and C/EBPbeta RL Mol. Cell. Biol. 15:4971-4979 (1995). RN [10] RA Naumann M., Scheidereit C. RT Activation of NF-6B in vivo is regulated by multiple phosphorylations RL EMBO J. 13:4597-4607 (1994). RN [11] RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., RA DeRaemy-Schenk A.-M., Chen B. P. C., Hai T., DeLamarter J. F., Whelan J. RT Cyclic AMP-independent ATF family members interact RT with NF-kappaB and function in the activation of the RT E-selectin promoter in response to cytokines RL Mol. Cell. Biol. 13:7180-7190 (1993). RN [12] RA Stein B., Cogswell P. C., Baldwin A. S. RT Functional and physical associations between NF-kappaB RT and C/EBP family members: a Rel domain-bZIP interaction RL Mol. Cell. Biol. 13:3964-3974 (1993). RN [13] RA Duckett C. S., Perkins N. D., Kowalik T. F., Schmid RA R. M., Huang E.-S., A. S. Baldwin jr., Nabel G. J. RT Dimerization of NF-KB2 with RelA(p65) regulates DNA RT binding, transcriptional activation, and inhibition RT by an IkappaB-alpha (MAD-3) RL Mol. Cell. Biol. 13:1315-1322 (1993). RN [14] RA Ganchi P. A., Sun S. C., Greene W. C., Ballard D. W. RT A novel NF-kappaB complex containing p65 homodimers: RT implications for transcriptional control at the level RT of subunit dimerization RL Mol. Cell. Biol. 13:7826-7835 (1993). RN [15] RA Coleman T. A., Kunsch C., Maher M., Ruben S. M., Rosen C. A. RT Acquisition of NFKB1-selective DNA binding by substitution RT of four amino acid residues from NFKB1 into RelA RL Mol. Cell. Biol. 13:3850-3859 (1993). RN [16] RA Perkins N. D., Edwards N. L., Duckett C. S., Agranoff RA A. B., Schmid R. M., Nabel G. J. RT A cooperative interaction between NF-kappaB and Sp1 RT is required for HIV-1 enhancer activation RL EMBO J. 12:3551-3558 (1993). RN [17] RA Blair W. S., Bogerd H. P., Madore S. J., Cullen B. R. RT Mutational analysis of the transcription activation RT domain of RelA: identification of a highly synergistic RT minimal acidic activation module RL Mol. Cell. Biol. 14:7226-7234 (1994). RN [18] RA Neumann M., Grieshammer T., Chuvpilo S., Kneitz B., RA Lohoff M., Schimpl A., Franza Jr. B. R., Serfling E. RT ReIA/p65 is a molecular target for the immunosuppressive RT action of protein kinase A RL EMBO J. 14:1991-2004 (1995). RN [19] RA Beg A. A., Ruben S. M., Scheinman R. I., Rosen C. A., A. S. Baldwin jr. RT IkappaB interacts with the nuclear localization sequences RT of the subunits of the NF-kappaB: a mechanism for cytoplasmic retention RL Genes Dev. 6:1899-1913 (1992). RN [20] RA Duyao M. P., Kessler D. J., Spicer D. B., Bartholomew RA C., Cleveland J. L., Siekevitz M., Sonenshein G. E. RT Transactivation of the c-myc promoter by human T cell RT leukemia virus type I tax is mediated by NFkappaB RL J. Biol. Chem. 267:16288-16291 (1992). RN [21] RA Narayanan R., Klement J. F., Ruben S. M., Higgins K. A., Rosen C. A. RT Identification of a naturally occurring transforming RT variant of the p65 subunit of NF-kappaB RL Science 256:367-370 (1992). RN [22] RA Stein B., A. S. Baldwin jr., Ballard D. W., Greene RA W. C., Angel P., Herrlich P. RT Cross-coupling of the NF-kappaB p65 and Fos/Jun transcription RT factors produces potentiated biological function RL EMBO J. 12:3879-3891 (1993). RN [23] RA Higgins K. A., Perez J. R., Coleman T. A., Dorshkind RA K., McComas W. A., Sarmiento U. M., Rosen C. A., Narayanan R. RT Antisense inhibition of the p65 subunit of NF-kappaB RT blocks tumorigenicity and causes tumor regression RL Proc. Natl. Acad. Sci. USA 90:9901-9905 (1993). RN [24] RA Perkins N. D., Agranoff A. B., Pascal E., Nabel G. J. RT An interaction the DNA-binding domains of RelA(p65) RT and Sp1 mediates human immunodeficiency virus gene activation RL Mol. Cell. Biol. 14:6570-6583 (1994). RN [25] RA Ballard D. W., Dixon E. P., Peffer N. J., Bogerd H., RA Doerre S., Stein B., Greene W. C. RT The 65-kDa subunit of human NF-kappaB functions as RT a potent transcriptional activator and a target for RT v-Rel-mediated repression RL Proc. Natl. Acad. Sci. USA 89:1875-1879 (1992). RN [26] RA Hansen S. K., Nerlov C., Zabel U., Verde P., Johnsen RA M., Baeuerle P., Blasi F. RT A novel complex between the p65 subunit of NF-kappaB RT and c-Rel binds to a DNA element involved in the phorbol RT ester induction of the human urokinase gene RL EMBO J. 11:205-213 (1992). RN [27] RA Errede B., Ammerer G. RT STE12, a protein involved in cell-type-specific transcription RT and signal transduction in yeast, is part of protein-DNA complexes RL Genes Dev. 3:1349-1361 (1989). RN [28] RA Urban M. B., Baeuerle P. A. RT The 65-kD subunit of NF-kappaB is a receptor for IkappaB RT and a modulator of DNA-binding specificity RL Genes Dev. 4:1975-1984 (1990). RN [29] RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB RT catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 11:2424-2430 (1991). RN [30] RA Baeuerle P., Baltimore D. RT A 65-kD subunit of active NF-kappaB is required for RT inhibition of NF-kappaB by IkappaB RL Genes Dev. 3:1689-1698 (1989). RN [31] RA Zabel U., Bauerle P. A. RT Purified human IkappaB can rapidly dissociate the RT complex of the NF-kappaB transcription factor with its cognate DNA RL Cell 61:255-265 (1990). RN [32] RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). XX // AC T00595 XX ID T00595 XX DT 03.06.93 (created); ewi. DT 07.01.97 (updated); hiwi. XX FA RelA XX SY NF-kappaB (p65); Rel-A; p65; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0020; Rel; 4.1.1.0.3.1. XX SZ 549 AA; 60.2 kDa (cDNA), 65 kDa (SDS) XX SQ MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT SQ IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQC SQ VKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLS SQ HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS SQ QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE SQ KRKRTYETFKSIMKKSPFNGPTEPRPPTRRIAVPTRNSTSVPKPAPQPYTFPASLSTINF SQ DEFSPMLLPSGQISNQALALAPSSAPVLAQTMVPSSAMVPLAQPPAPAPVLTPGPPQSLS SQ APVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNSTDPGVFTDLASVDNSEFQQLLNQG SQ VSMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNGLSGDEDFSSIADMDF SQ SALLSQISS XX SC SwissProt #Q04207 XX FT 19 304 Rel homology region FT 524 549 trans-activation domain 1 (TA1, by homology) [1]; FT 457 482 trans-activation domain 1' (TA1', by homology) [1]; XX SF the Rel domain constitutes the DNA-contacting domain SF either in homo- or in heterodimers [2]; SF the affinity of the homodimer to kappaB sites is 4-fold SF to 13-fold lower than that of p50/p65 heterodimers [4]; SF cytoplasmic inhibitors (IkappaB-alpha and -beta) bind SF to the Rel domain of RelA [2], [7]; SF dimerization is important for inhibitor binding [5]; XX CP ubiquitous XX FF the heterodimer with p50 avidly binds to asymmetric DNA-sequences; FF at some sequences, its homodimers may act as transcriptional activators [2]; FF target for the cytoplasmic inhibitor IkappaB [3], [9]; FF RelA establishes an autoreguatory loop by activating FF the IkappaB-alpha gene [5]; FF disruption of the RelA gene causes massive liver degeneration FF and embryonic lethality [6]; XX IN T00168; c-Rel; human, Homo sapiens. IN T00413; IkappaB; human, Homo sapiens. IN T00414; IkappaB-beta; human, Homo sapiens. IN T00416; IkappaB-beta; chick, Gallus gallus. IN T00595; RelA; mouse, Mus musculus. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00950; IkappaB-alpha; human, Homo sapiens. IN T00971; IkappaB-beta; mouse, Mus musculus. IN T01923; NF-kappaB1; mouse, Mus musculus. IN T01936; IkappaB; mouse, Mus musculus. XX MX M00052; V$NFKAPPAB65_01 XX BS R00879; MOUSE$IGKL_03; Quality: 6; mouse, Mus musculus BS R01058; MOUSE$M1H2KB_06; Quality: 6; mouse, Mus musculus XX DR EMBL: M61909; MMNFKP65(r). DR SwissProt: Q04207; TF65_MOUSE. DR PIR: A37932; A37932. XX RN [1] RA Schmitz M. L., dos Santos Silva M. A., Baeuerle P. A. RT Transactivation domain 2 (TA2) of p65 NF-kappaB RL J. Biol. Chem. 270:15576-15584 (1995). RN [2] RA Nolan G. P., Ghosh S., Liou H.-C., Tempst P., Baltimore D. RT DNA binding and IkappaB inhibition of the cloned p65 RT subunit of NF-kappaB, a rel-related polypeptide RL Cell 64:961-969 (1991). RN [3] RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB RT transcription factor involves dissociation of an apparently RT cytoplasmic NF-kappaB/inhibitor complex RL Cold Spring Harbor Symp. Quant. Biol. 53:789-798 (1989). RN [4] RA Fujita T., Nolan G. P., Ghosh S., Baltimore D. RT Independent modes of transcriptional activation by RT the p50 and p65 subunits of NF-kappaB RL Genes Dev. 6:775-787 (1992). RN [5] RA Gustafson T. A., Kedes L. RT Identification of Multiple Proteins That Interact RT with Functional Regions of the Human Cardiac alpha-Actin Promoter RL Mol. Cell. Biol. 9:3269-3283 (1989). RN [6] RA Beg A. A., Sha W. C., Bronson R. T., Ghosh S., Baltimore D. RT Embryonic lethality and liver degeneration in mice RT lacking the ReIA component of NF-kappaB RL Nature 376:167-170 (1995). RN [7] RA Thompson J. E., Phillips R. J., Erdjument-Bromage H., Tempst P., Ghosh S. RT IkappaB-beta regulates the persistent response in RT a biphasic activation of NF-kappaB RL Cell 80:573-582 (1995). RN [8] RA Kitajima I., Shinohara T., Bilakovics J., Brown D. A., Xu X., Nerenberg M. RT Ablation of transplanted HTLV-I Tax-transformed tumors RT in mice by antisense inhibition of NF-kappaB RL Science 258:1792-1795 (1992). RN [9] RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB RT catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 11:2424-2430 (1991). XX // AC T00596 XX ID T00596 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NF-kappaE1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R00897; HS$IGKL_02; Quality: 6; human, Homo sapiens XX RN [1] RA Gimble J. M., Flanagan J. R., Recker D., Max E. E. RT Identification and partial purification of a protein RT binding to the human immunoglobulin kappa enhancer kE2 site RL Nucleic Acids Res. 16:4967-4988 (1988). XX // AC T00597 XX ID T00597 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NF-kappaE2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO NF-muE2 XX SZ 30 kDa XX BS R00897; HS$IGKL_02; Quality: 6; human, Homo sapiens BS R02795; HS$TCRA_03; Quality: 6; human, Homo sapiens XX RN [1] RA Gimble J. M., Flanagan J. R., Recker D., Max E. E. RT Identification and partial purification of a protein RT binding to the human immunoglobulin kappa enhancer kE2 site RL Nucleic Acids Res. 16:4967-4988 (1988). XX // AC T00598 XX ID T00598 XX DT 15.10.92 (created); ewi. DT 20.04.95 (updated); ewi. XX FA NF-kappaE3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO NF-muE3 XX RN [1] RA Gimble J. M., Flanagan J. R., Recker D., Max E. E. RT Identification and partial purification of a protein RT binding to the human immunoglobulin kappa enhancer kE2 site RL Nucleic Acids Res. 16:4967-4988 (1988). XX // AC T00599 XX ID T00599 XX DT 25.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA NF-1/L XX SY NF-1A1.1 (chick); NF1/L; RPF-A (hamster); XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 1.4.1.0.1.2. XX SZ >505 AA; 54.4 kDa (cDNA); 250 kDa (GF) XX SQ LCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEK SQ PEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQAD SQ KVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVH SQ AADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNF SQ SLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSG SQ SQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHAT SQ PSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQ SQ GKVHNPFLPTPMLPPPPPPPMARPVPLPMPDTKPPTTSTEGGAASPTSPTYSTPSTSPAN SQ RFVSVGPRDPSFVNIPQQTQSWYLG XX SC SwissProt #P09414 XX FT 1 240 induction of adenoviral replication FT 11 240 DNA-binding and dimerization FT 24 33 essential for DNA-binding FT 24 33 dispensable for dimerization XX CP (liver) XX MX M00056; V$MYOGNF1_01 XX BS R00078; HS$ALBU_02; Quality: 6; human, Homo sapiens BS R00079; HS$ALBU_03; Quality: 6; human, Homo sapiens BS R00421; HS$FIX_01; Quality: 6; human, Homo sapiens BS R01322; HS$RBP_01; Quality: 6; human, Homo sapiens BS R02209; NF1$CONS; Quality: 6 BS R02991; RAT$PFK_07; Quality: 6; rat, Rattus norvegicus XX DR EMBL: X13167; RNNF1L(r). DR SwissProt: P09414; NFIL_RAT. DR PIR: S01300; S01300. XX RN [1] RA Paonessa G., Gounari F., Frank R., Cortese R. RT Purification of a NF1-like DNA-binding protein from RT rat liver and cloning of the corresponding cDNA RL EMBO J. 7:3115-3123 (1988). RN [2] RA Gounari F., De Francesco R., Schmitt J., van der Vliet RA P., Cortese R., Stunnenberg H. RT Amino-terminal domain of NF1 binds to DNA as a dimer RT and activates adenovirus DNA replication RL EMBO J. 9:559-566 (1990). XX // AC T00600 XX ID T00600 XX DT 17.11.92 (created); ewi. XX FA NF-lambda2 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX FF activator of Ig-lambda XX BS R02380; MOUSE$IGLL_01; Quality: 6; mouse, Mus musculus XX RN [1] RA Chang L. A., Murialdo H. RT Interaction of a nuclear protein with a palindromic RT sequence of the mouse immunoglobulin lambda2-chain RT gene promoter is important for its transcription RL Mol. Cell. Biol. 10:5894-5902 (1990). XX // AC T00601 XX ID T00601 XX DT 15.10.92 (created); ewi. XX FA NF-1 (-like proteins) XX SY NF-1; NF-I; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX BS R00015; CHICK$ACRA_05; Quality: 5; chick, Gallus gallus BS R01192; CHICK$OA_01; Quality: 1; chick, Gallus gallus BS R01621; CHICK$STN1_02; Quality: 6; chick, Gallus gallus BS R01622; CHICK$STN1_03; Quality: 6; chick, Gallus gallus BS R01568; CHICK$VIT2_01; Quality: 4; chick, Gallus gallus BS R01569; CHICK$VIT2_02; Quality: 4; chick, Gallus gallus BS R02209; NF1$CONS; Quality: 6 XX DR Compel: C00001 DR Compel: C00006 XX RN [1] RA Bradshaw M. S., Tsai M.-J., O'Malley B. W. RT A Far Upstream Ovalbumin Enhancer Binds Nuclear Factor-1-like Factor RL J. Biol. Chem. 263:8485-8490 (1988). RN [2] RA Kryszke M.-H., Piette J., Yaniv M. RT Induction of a factor that binds to the polyoma virus RT A enhancer on differentiation of embryonal carcinoma cells RL Nature 328:254-256 (1987). RN [3] RA Philipsen J. N. J., Hennis B. C., Ab G. RT In vivo footprinting of the estrogen-inducible vitellogenin RT II gene from chicken RL Nucleic Acids Res. 16:9663-9676 (1988). RN [4] RA Nikovits jr. W., Mar J. H., Ordahl C. P. RT Muscle-Specific Activity of the Skeletal Troponin RT I Promoter Requires Interaction between Upstream Regulatory RT Sequences and Elements Contained within the First Transcribed Exon RL Mol. Cell. Biol. 10:3468-3482 (1990). RN [5] RA Perkins N. D., Nicolas R. H., Plumb M. A., Goodwin G. H. RT The purification of an erythroid protein which binds RT to enhancer and promoter elements of haemoglobin genes RL Nucleic Acids Res. 17:1299-1314 (1989). RN [6] RA Piette J., Klarsfeld A., Changeux J.-P. RT Interaction of nuclear factors with the upstream region RT of the alpha-subunit gene of chicken muscle acetylcholine RT receptor: variations with muscle differentiation and denervation RL EMBO J. 8:687-694 (1989). XX // AC T00602 XX ID T00602 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NF-MHCIIA XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01069; RABBIT$M2DB_01; Quality: 6; rabbit, Oryctolagus cuniculus XX RN [1] RA Sittisombut N. RT Two Distinct Nuclear Factors Bind the Conserved Regulatory RT Sequence of a Rabbit Major Histocompatibility Complex Class II Gene RL Mol. Cell. Biol. 8:2034-2041 (1988). XX // AC T00603 XX ID T00603 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NF-MHCIIB XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01070; RABBIT$M2DB_02; Quality: 6; rabbit, Oryctolagus cuniculus XX RN [1] RA Sittisombut N. RT Two Distinct Nuclear Factors Bind the Conserved Regulatory RT Sequence of a Rabbit Major Histocompatibility Complex Class II Gene RL Mol. Cell. Biol. 8:2034-2041 (1988). XX // AC T00604 XX ID T00604 XX DT 25.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA NF-1/Red1 XX SY NF-1B1 (chick); NFI-B1; RPF-B; XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX CL ; ; 1.4.1.0.2.1. XX SZ 561 AA; 62 kDa (cDNA) XX SQ MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDE SQ LLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDC SQ LRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFL SQ AYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFP SQ IGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPNSPAAGS SQ RTWHERDQDMSSPTTMKKPEKPLFSSTSPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTP SQ PPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNSSG SQ QVVGKVPGHFTPVLAPSPHPSAVRPVTLTMTDTKPITTSTEAYTASGTSQASRYVGLNPR SQ DPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPA SQ NVQNYGLNIIGEPFLQAETSN XX SC SwissProt #P13622 XX FF may act as a repressor (e.g. on the proenkephalin upon cotransfection) XX MX M00056; V$MYOGNF1_01 XX BS R02209; NF1$CONS; Quality: 6 XX DR EMBL: J04122; MANF1A(r). DR SwissProt: P13622; NFIR_MESAU. DR PIR: A31256; A31256. XX RN [1] RA Gil G., Smith J. R., Goldstein J. L., Slaughter C. RA A., Orth K., Brown M. S., Osborne T. F. RT Multiple genes encode nuclear factor 1-like proteins RT that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme RT A reductase RL Proc. Natl. Acad. Sci. USA 85:8963-8967 (1988). RN [2] RA Chu H.-M., Fischer W. H., Osborne T. F., Comb M. J. RT NF-I proteins from brain interact with the proenkephalin RT cAMP inducible enhancer RL Nucleic Acids Res. 19:2721 (1991). XX // AC T00605 XX ID T00605 XX DT 26.01.93 (created); hse. XX FA NF-S XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF binds to MHC class II alpha-chain gene promoters XX BS R02219; NFS$CONS; Quality: 6 XX RN [1] RA Kobr M., Reith W., Herrero-Sanchez C., Mach B. RT Two DNA-binding proteins discriminate between the RT promoters of different members of the major histocompatibility RT complex class II multigene family RL Mol. Cell. Biol. 10:965-971 (1990). XX // AC T00606 XX ID T00606 XX DT 13.11.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NF-TNF XX SY NF-kappaB-like factor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX FF induced by tumor necrosis factor alpha (TNF-alpha) XX BS R01095; MOUSE$B2MG_02; Quality: 6; mouse, Mus musculus BS R00879; MOUSE$IGKL_03; Quality: 6; mouse, Mus musculus BS R01057; MOUSE$M1H2KB_05; Quality: 6; mouse, Mus musculus BS R02338; MOUSE$MHC2IN_01; Quality: 6; mouse, Mus musculus XX RN [1] RA Pessara U., Koch N. RT Tumor necrosis factor alpha regulates expression of RT the major histocompatibility complex class II-associated RT invariant chain by binding of an NF-kappaB-like factor to a promoter element RL Mol. Cell. Biol. 10:4146-4154 (1990). XX // AC T00607 XX ID T00607 XX DT 15.10.92 (created); ewi. XX FA NF-U1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01250; HS$PBGD_04; Quality: 6; human, Homo sapiens XX RN [1] RA Mignotte V., Wall L., deBoer E., Grosveld F., Romeo P.-H. RT Two tissue-specific factors bind to the erythroid RT promoter of the human porphobilinogen deaminase gene RL Nucleic Acids Res. 17:37-54 (1989). XX // AC T00608 XX ID T00608 XX DT 15.10.92 (created); ewi. DT 26.01.93 (updated); hse. XX FA NF-W1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 60 kDa (sedim.); 64 kDa (SDS) XX CP B cells XX BS R01072; MOUSE$M2EAD_02; Quality: 6; mouse, Mus musculus BS R02220; NFW1$CONS; Quality: 6 XX RN [1] RA Dorn A., Benoist C., Mathis D. RT New B-Lymphocyte-Specific Enhancer-Binding Protein RL Mol. Cell. Biol. 9:312-320 (1989). XX // AC T00609 XX ID T00609 XX DT 15.10.92 (created); ewi. DT 26.01.93 (updated); hse. XX FA NF-W2 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 50-75 kDa (GF); 64+20 kDa (SDS) XX CP ubiquitous XX BS R01073; MOUSE$M2EAD_03; Quality: 6; mouse, Mus musculus BS R02221; NFW2$CONS; Quality: 6 XX RN [1] RA Dorn A., Benoist C., Mathis D. RT New B-Lymphocyte-Specific Enhancer-Binding Protein RL Mol. Cell. Biol. 9:312-320 (1989). XX // AC T00610 XX ID T00610 XX DT 25.01.93 (created); ewi. DT 15.08.96 (updated); ewi. XX FA NF-1X XX SY NF-1/X; NFI-X; XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX HO NF-1X2 (X. laevis) XX SZ 441 AA; 48.8 kDa (cDNA) XX SQ MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDEL SQ LGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCL SQ RQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLA SQ YFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASG SQ PNFSLADLESPSYYNINQVTLGRRSITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGR SQ SPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPG SQ SPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQHS SQ QRQAPPLPAGLSASDPGTATF XX SC SwissProt #P13623 XX MX M00056; V$MYOGNF1_01 XX BS R02209; NF1$CONS; Quality: 6 XX DR EMBL: J04123; MANF1B(r). DR SwissProt: P13623; NFIX_MESAU. DR PIR: B31256; B31256. XX RN [1] RA Gil G., Smith J. R., Goldstein J. L., Slaughter C. RA A., Orth K., Brown M. S., Osborne T. F. RT Multiple genes encode nuclear factor 1-like proteins RT that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme RT A reductase RL Proc. Natl. Acad. Sci. USA 85:8963-8967 (1988). XX // AC T00611 XX ID T00611 XX DT 15.10.92 (created); ewi. XX FA NF-X2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01087; HS$M2DRA_02; Quality: 6; human, Homo sapiens XX RN [1] RA Tsang S. Y., Nakanishi M., Peterlin B. M. RT Mutational Analysis of the DRA Promoter: cis-Acting RT Sequences and trans-Acting Factors RL Mol. Cell. Biol. 10:711-719 (1990). XX // AC T00612 XX ID T00612 XX DT 15.10.92 (created); ewi. XX FA NF-Xc XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01087; HS$M2DRA_02; Quality: 6; human, Homo sapiens XX RN [1] RA Tsang S. Y., Nakanishi M., Peterlin B. M. RT Mutational Analysis of the DRA Promoter: cis-Acting RT Sequences and trans-Acting Factors RL Mol. Cell. Biol. 10:711-719 (1990). XX // AC T00613 XX ID T00613 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA NF-Y XX SY NF-YA + NF-YB; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO AIC1 XX SZ >200 kDa XX SF 2 subunits: A and B XX FF activator; FF required for reinitiation XX MX M00209; V$NFY_C XX BS R00090; MOUSE$ALBU_09; Quality: 2; mouse, Mus musculus BS R01076; MOUSE$M2EAK_03; Quality: 6; mouse, Mus musculus BS R01080; MOUSE$M2EAK_07; Quality: 6; mouse, Mus musculus BS R01081; MOUSE$M2EAK_08; Quality: 6; mouse, Mus musculus BS R01942; MOUSE$M2IAA_08; Quality: 6; mouse, Mus musculus XX DR EMBL: X55315; MMNFYA(r). DR EMBL: M86214; MMNFYA1(r). DR EMBL: M86215; MMNFYAB(r). DR EMBL: X55316; MMNFYB(r). DR SwissProt: P22569; CBFA_MOUSE. DR SwissProt: P23708; CBFB_MOUSE. DR PIR: A23692; A23692. DR PIR: A38245; A38245. DR PIR: F38245; F38245. DR PIR: S12044; S12044. DR PIR: S12045; S12045. XX RN [1] RA Dorn A., Fehling H. J., Koch W., Le Meur M., Gerlinger RA P., Benoist C., Mathis D. RT B-Cell Control Region at the 5' End of a Major Histocompatibility RT Complex Class II Gene: Sequences and Factors RL Mol. Cell. Biol. 8:3975-3987 (1988). RN [2] RA Dorn A., Durand B., Marfing C., Le Meur M., Benoist C., Mathis D. RT Conserved major histocompatibility complex class II RT boxes-X and Y-are transcriptional control elements RT and specifically bind nuclear proteins RL Proc. Natl. Acad. Sci. USA 84:6249-6253 (1987). RN [3] RA Dorn A., Bollekens J., Staub A., Benoist C., Mathis D. RT A Multiplicity of CCAAT Box-Binding Proteins RL Cell 50:863-872 (1987). RN [4] RA Mantovani R., Pessara U., Tronche F., Li X.-Y., Knapp RA A.-M., Pasquali J.-L., Benoist C., Mathis D. RT Monoclonal antibodies to NF-Y define its function RT in MHC class II and albumin gene transcription RL EMBO J. 11:3315-3322 (1992). RN [5] RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., RA Monaci P., Cladaras C., Zannis V. I. RT Promoter elements and factors involved in hepatic RT transcription of the human ApoA-I gene positive and RT negative regulators bind to overlapping sites RL J. Biol. Chem. 266:5790-5797 (1991). RN [6] RA Mantovani R., Pessara U., Tronche F., Li X.-Y., Knapp RA A.-M., Pasquali J.-L., Benoist C., Mathis D. RT Monoclonal antibodies to NF-Y define its function RT in MHC class II and albumin gene transcription RL EMBO J. 11:3315-3322 (1992). XX // AC T00614 XX ID T00614 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); hwi; ewi. XX FA NF-Y' XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO AIC1 XX BS R01446; HSV1$TK_05; Quality: 6; HSV-1, herpes simplex virus type 1 XX DR Compel: C00069 XX RN [1] RA Dorn A., Bollekens J., Staub A., Benoist C., Mathis D. RT A Multiplicity of CCAAT Box-Binding Proteins RL Cell 50:863-872 (1987). RN [2] RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., RA Monaci P., Cladaras C., Zannis V. I. RT Promoter elements and factors involved in hepatic RT transcription of the human ApoA-I gene positive and RT negative regulators bind to overlapping sites RL J. Biol. Chem. 266:5790-5797 (1991). XX // AC T00615 XX ID T00615 XX DT 26.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA NF-YA XX SY CBF-B (rat); CP1B (human, rat); HAP2 (yeast); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 1.6.1.0.2. XX SZ 312 AA; 318 AA; 340 AA; 346 AA; 34 kDa (cDNA, 318 AA form); 40 kDa (SDS) XX SQ MEQYTTNSNSSTEQIVVQAGQIQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPLM SQ VQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAVQ SQ VQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTILQ SQ QVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMVP SQ GAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHE SQ SRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS XX SC SwissProt #P23708 XX FT 5 12 serine-/threonine-rich region FT 18 57 glutamine-rich region FT 26 53 encoded by exon B, deleted in the short form FT 91 160 glutamine-rich region FT 182 187 encoded by the first part of exon F, may be deleted FT 205 222 serine-/threonine-rich region FT 262 317 HAP2 homologous region FT 272 311 basic region XX SF (all features for 346 AA form) SF glutamine-rich region XX FF binds to Y-box elements of MHC class II genes XX IN T00087; CBF-A; rat, Rattus norvegicus. IN T00154; CP1A; human, Homo sapiens. IN T00350; HAP3; yeast, Saccharomyces cerevisiae. IN T00351; HAP4; yeast, Saccharomyces cerevisiae. IN T00616; NF-YB; mouse, Mus musculus. IN T01263; HAP3; fission yeast, Schizosaccharomyces pombe. XX MX M00209; V$NFY_C XX DR EMBL: X55315; MMNFYA(r). DR EMBL: M86214; MMNFYA1(r). DR EMBL: M86215; MMNFYAB(empty). DR SwissProt: P23708; CBFB_MOUSE. DR PIR: A38245; A38245. DR PIR: S12044; S12044. XX RN [1] RA Li X. Y., Hooft van Huijsduijnen R., Mantovani R., Benoist C., Mathis D. RT Intro-exon organization of the NF-Y genes. Tissue-specific RT splicing modifies an activation domain RL J. Biol. Chem. 267:8984-8990 (1992). RN [2] RA Hooft van Huijsduijnen R., Li X. Y., Black D., Matthes RA H., Benoist C., Mathis D. RT Co-evolution from yeast to mouse: cDNA cloning of RT the two NF-Y (CP-1/CBF) subunits RL EMBO J. 9:3119-3127 (1990). XX // AC T00616 XX ID T00616 XX DT 26.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA NF-YB XX SY CBF-A (rat); CP1a (human, rat); HAP3 (yeast); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 1.6.1.0.1. XX SZ 207 AA; 22.8 kDa (cDNA); 32 kDa (SDS) XX SQ MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLP SQ IANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILF SQ AMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVSATDGLSEELTEEAFTNQLPAGLIT SQ ADGQQQNVMVYTTSYQQISGVQQIQFS XX SC SwissProt #P22569 XX FT 1 26 domain A1 FT 26 50 domain A2 FT 33 44 acidic region FT 51 140 domain B, nearly identical in all animal species FT 53 142 HAP3 homologous region FT 141 180 domain C1 FT 159 168 acidic region FT 180 205 domain C2 FT 184 205 glutamine-rich region XX SF glutamine-rich region, acidic region, zinc finger ? XX FF binds to Y-box elements of MHC class II genes XX IN T00088; CBF-B; rat, Rattus norvegicus. IN T00157; CP1B; human, Homo sapiens. IN T00347; HAP2; human, Homo sapiens. IN T00349; HAP2; yeast, Saccharomyces cerevisiae. IN T00351; HAP4; yeast, Saccharomyces cerevisiae. IN T00615; NF-YA; mouse, Mus musculus. XX MX M00209; V$NFY_C XX DR EMBL: X55316; MMNFYB(r). DR SwissProt: P22569; CBFA_MOUSE. DR PIR: A23692; A23692. DR PIR: F38245; F38245. DR PIR: S12045; S12045. XX RN [1] RA Maity S. N., Sinha S., Ruteshouser E. C., de Crombrugghe B. RT Three different polypeptides are necessary for DNA RT binding of the mammalian heteromeric CCAAT binding factor RL J. Biol. Chem. 267:16574-16580 (1992). RN [2] RA Li X. Y., Hooft van Huijsduijnen R., Mantovani R., Benoist C., Mathis D. RT Intro-exon organization of the NF-Y genes. Tissue-specific RT splicing modifies an activation domain RL J. Biol. Chem. 267:8984-8990 (1992). RN [3] RA Hooft van Huijsduijnen R., Li X. Y., Black D., Matthes RA H., Benoist C., Mathis D. RT Co-evolution from yeast to mouse: cDNA cloning of RT the two NF-Y (CP-1/CBF) subunits RL EMBO J. 9:3119-3127 (1990). XX // AC T00617 XX ID T00617 XX DT 15.10.92 (created); ewi. XX FA NF-Zz XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01926; HS$M2DRA_07; Quality: 6; human, Homo sapiens XX RN [1] RA Tsang S. Y., Nakanishi M., Peterlin B. M. RT Mutational Analysis of the DRA Promoter: cis-Acting RT Sequences and trans-Acting Factors RL Mol. Cell. Biol. 10:711-719 (1990). XX // AC T00618 XX ID T00618 XX DT 15.10.92 (created); ewi. XX FA NF-Zc XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01926; HS$M2DRA_07; Quality: 6; human, Homo sapiens XX RN [1] RA Tsang S. Y., Nakanishi M., Peterlin B. M. RT Mutational Analysis of the DRA Promoter: cis-Acting RT Sequences and trans-Acting Factors RL Mol. Cell. Biol. 10:711-719 (1990). XX // AC T00619 XX ID T00619 XX DT 26.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA NGFI-B XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.2.5.1. XX SZ 563 AA; 63-88 kDa (SDS); 61 kDa (cDNA) XX SQ MDLASPETAPTAPATLPSFSTFMDGGYTGEFDTFLYQLPGTAQPCSSASSTSSSSSSATS SQ PASASFKFEDFQVYGCYPGTLSGPLDETLSSSGSDYYGSPCSAPSPPTPNFQPSQLSPWD SQ GSFGHFSPSQTYEGLRVWTEQLPKASGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPAPAT SQ HQLGEGESYSVPAAFPGLAPTSPNCDTSGILDAPVTSTKARSGSSGGSEGRCAVCGDNAS SQ CQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKE SQ VVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPNTAKLDYSKFQELVLPRF SQ GKEDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELSPGDQDLLLESAFLELFILRLAYRS SQ KPGEGKLIFCSGLVLHRLQCARGFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDR SQ HGLQDPRRVEELQNRIASCLKEHMAAVAGDPQPASCLSRLLGKLPELRTLCTQGLQRIFC SQ LKLEDLVPPPPIVDKIFMDTLSF XX SC SwissProt #P22829 XX SF phosphorylation XX FF member of the steroid hormone receptor superfamily XX BS R03961; AS$NGFIB_01; Quality: 2 BS R02222; NGFIB$CONS; Quality: 6 XX DR SwissProt: P22829; NGFI_RAT. DR PIR: JQ0623; JQ0623. XX RN [1] RA Watson M. A., Milbrandt J. RT The NGFI-B gene, a transcriptionally inducible member RT of the steroid receptor gene superfamily: genomic RT structure and expression in rat brain after seizure induction RL Mol. Cell. Biol. 9:4213-4219 (1989). RN [2] RA Fahrner T. J., Carroll S. L., Milbrandt J. RT The NGFI-B protein, an inducible member of the thyroid/steroid RT receptor family, is rapidly modified posttranslationally RL Mol. Cell. Biol. 10:6454-6459 (1990). XX // AC T00620 XX ID T00620 XX DT 09.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA NGFI-C XX SY pAT 133 (hu); XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; . XX SZ >= 478 AA XX SQ MLHLSDFSGPDALLSKPTEGCAHTSPELPRLPARDAPSAAAYPGGDFLSWALSTCGAGGD SQ LTDSCFLEGPAPTPPSGLSYSGSFFIQAVPEHPHDPEALFNLMSGILGLAPFPSPEAAAS SQ RSPLDVPFPAGPDALLPDLYSPDLSSAAFPEAFWEAAPSAGAPSQCLFEPQLSPPDVKPG SQ LRAPPASPALDAAASAFKGPYAPWELLSAGAPGNCGSQGSFQTTPEARFSAVGTKVEDLL SQ SISCPAELPGPASRLYPPGAYDAFSLAPGDLGEGTEGLPALLTPPGGEGGSGGEGGEFLA SQ VPQAQLSPLGLRGAATADFSKALVADLPGGSGVAAPSSPATSFPAAKARRKGRRGGKCSA SQ RCFCPRPHVKAFACPVESCVRTFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTH SQ VRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKGLGFYSLGLSFAAL XX SC SwissProt #Q00911 XX SF 3 zinc finger motifs SF proline-rich region XX FF same binding site as Krox-20 and Krox-24 XX MX M00244; V$NGFIC_01 XX BS R03332; AS$NGFIC_01; Quality: 6 XX DR EMBL: M65008; RRNGFIC(r). DR SwissProt: Q00911; NGFC_RAT. DR PIR: A41246; A41246. XX RN [1] RA Siderovski D. P., Blum S., Forsdyke R. E., Forsdyke D. R. RT A set of human putative lymphocyte Go/G1 switch genes RT includes genes homologous to rodent cytokine and zinc RT finger protein-encoding genes RL DNA Cell Biol. 9:579-587 (1990). RN [2] RA Crosby S. D., Puetz J. J., Simburger K. S., Fahrner T. J., Milbrandt J. RT The early response gene NGFI-C encodes a zinc finger RT transcriptional activator and is a member of the GCGGGGGCG RT (GSG) element-binding protein family RL Mol. Cell. Biol. 11:3835-3841 (1991). RN [3] RA Mueller H.-J., Skerka C., Bialonski A., Zipfel P. F. RT Clone pAT 133 identifies a gene that encodes another RT human member of a class of growth factor-induced genes RT with almost identical zinc-finger domains RL Proc. Natl. Acad. Sci. USA 88:10079-10083 (1991). XX // AC T00621 XX ID T00621 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NHP-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 70 kDa XX BS R01572; CHICK$VIT2_05; Quality: 2; chick, Gallus gallus BS R01905; CHICK$VIT2_19; Quality: 2; chick, Gallus gallus BS R01906; XENLA$VITA2_02; Quality: 6; clawed frog, Xenopus laevis XX RN [1] RA Feavers I. M., Jiricny J., Moncharmont B., Saluz H. P., Jost J. P. RT Interaction of two nonhistone proteins with the estradiol RT response element of the avian vitellogenin gene modulates RT the binding of estradiol-receptor complex RL Proc. Natl. Acad. Sci. USA 84:7453-7457 (1987). RN [2] RA Hughes M. J., Jost J.-P. RT The ubiquitous nuclear protein, NHP1, binds with high RT affinity to different sequences of the chicken vitellogenin II gene RL Nucleic Acids Res. 17:8511ff (1989). XX // AC T00622 XX ID T00622 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA NHP-2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 60 kDa XX BS R01574; CHICK$VIT2_07; Quality: 2; chick, Gallus gallus XX RN [1] RA Feavers I. M., Jiricny J., Moncharmont B., Saluz H. P., Jost J. P. RT Interaction of two nonhistone proteins with the estradiol RT response element of the avian vitellogenin gene modulates RT the binding of estradiol-receptor complex RL Proc. Natl. Acad. Sci. USA 84:7453-7457 (1987). RN [2] RA Hughes M. J., Jost J.-P. RT The ubiquitous nuclear protein, NHP1, binds with high RT affinity to different sequences of the chicken vitellogenin II gene RL Nucleic Acids Res. 17:8511ff (1989). XX // AC T00623 XX ID T00623 XX DT 15.10.92 (created); ewi. XX FA NHP3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX RN [1] RA Hughes M. J., Jost J.-P. RT The ubiquitous nuclear protein, NHP1, binds with high RT affinity to different sequences of the chicken vitellogenin II gene RL Nucleic Acids Res. 17:8511ff (1989). XX // AC T00624 XX ID T00624 XX DT 15.10.92 (created); ewi. XX FA NHP4 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01585; CHICK$VIT2_18; Quality: 4; chick, Gallus gallus XX RN [1] RA Hughes M. J., Jost J.-P. RT The ubiquitous nuclear protein, NHP1, binds with high RT affinity to different sequences of the chicken vitellogenin II gene RL Nucleic Acids Res. 17:8511ff (1989). XX // AC T00625 XX ID T00625 XX DT 09.11.92 (created); ewi. DT 27.08.96 (updated); ewi. XX FA Nil-2-a XX SY TCF8 (gene name); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; . XX SZ 735 AA; 80.5 kDa (cDNA) XX SQ MVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPI SQ QQGGHSVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLP SQ EDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINALPELKHYDLKQPTQPPPLPAAEAEKP SQ ESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAQELSKIADSVNLPLDVVKKWF SQ EKMQAGQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQHSTVNLQSPSKMTNSPVL SQ PVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAEGAQEEPQVEPLDLSLPKQQGELLER SQ STITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTA SQ QLPTIVAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDE SQ RQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGK SQ RPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRE SQ AEERDSTEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEE SQ LQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASSLGQKV SQ GESSEQVSEEKTNEA XX SC translated from EMBL #M81699 XX SF 3 zinc finger motifs XX CP T cells XX FF repressor of interleukin-2 expression XX BS R02304; HS$IL2_11; Quality: 6; human, Homo sapiens XX DR EMBL: M81699; HSNIL2A(r). XX RN [1] RA Williams T. M., Moolten D., Burlein J., Romano J., RA Bhaerman R., Godillot A., Mellon M., Rauscher III F. J., Kant J. A. RT Identification of a zinc finger protein that inhibits IL-2 gene expression RL Science 254:1791-1794 (1991). RN [2] RA Williams T. M., Montoya G., Wu Y., Eddy R. L., Byers M. G., Shows T. B. RT The TCF8 gene encoding a zinc finger protein (Nil-2-a) RT resides on human chromosome 10p11.2 RL Genomics 14:194-196 (1992). XX // AC T00626 XX ID T00626 XX DT 14.12.92 (created); ewi. DT 27.04.94 (updated); ewi. XX FA NIP XX OS gibbon ape, Hylobates lar OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; primates; haplorhini; catarrhini; hylobatidae XX BS R02735; HS$IL3_03; Quality: 6; human, Homo sapiens BS R03058; HS$STROM_01; Quality: 6; human, Homo sapiens XX RN [1] RA Mathey-Prevot B., Andrews N. C., Murphy H. S., Kreissman S. G., Nathan D. G. RT Positive and negative elements regulate human interleukin 3 expression RL Proc. Natl. Acad. Sci. USA 87:5046-5050 (1990). XX // AC T00627 XX ID T00627 XX DT 14.12.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA NIT2 XX OS Neurospora crassa OC eukaryota; plantae; thallobionta; eumycota; ascomycotina; OC pyrenomycetes; sordariales; sordariaceae XX CL C0004; CC; 2.2.1.2.1. XX SZ 1036 AA XX SQ MAASTTTPTATTRPFFTMNPTTTEHDFRFPRRPGDSMAGTGLGGAAMSSSSANNNHNQHH SQ PMSAFNHHHHHNAAGSARGRDSEGRPSSSNNNTSNGFVANINHQSSSNNNISKNIPPPTS SQ DYHTQSASNGAAAYDLLRSSAFPPFQDGLAGMTQSPDEMQKQDPLATQVWKYFAKTKLAL SQ PNQERMENLTWRMMAKPLQTYRRQMETDRTHRFSESAPQKSTSGIARLRKSSEQTQSQGS SQ DLMNLDDFINGENISTPAGLSLAPSPETSSKMADDRTAHHSTASAIPIKARKDQQSQHMI SQ PQSVPAALHHPRMQTEFGYLPRHLRKTSIDETSKRNPNRKRPADFSPHVSAVTPSYVTNG SQ LDADTDLHDYSLDHTSHDGLPPQTAPSSVPYALDTVGLDADTFITSAGPFQQNFSFSPST SQ SPMVSHDPFTAMFGPNNSSMHSGPINGNNFYSPPASAFQSTASTPHPMNEGGDNFYFGVD SQ MRRARQQPYQPGNHGMGNAMAHQFPYAGNGNMMFPASSAGQDPTPSFAAPNSFSGHIDPT SQ QVFHNEQAVRSPGMSVLQDSLFTFGAESDGDEEDGGAFADRNLSISHDFSSQGMEEPAFD SQ SPSMGWDPSLPGNFSTQAARYPGGPPRKQVTIGATTTDYVDNTGEWDGSGLPRSQSQSFR SQ QSDLRKGKMSRTASTPGLSARMNPFERLAQSASHSPPADVGRSSGLSSVPASRPSSPPPG SQ AKQGSTTNLQGAAGNSTDTPTTCTNCFTQTTPLWRRNPDGQPLCNACGLFLKLHGVVRPL SQ SLKTDVIKKRNRGSGASLPVGGTSTRSKKNASMSAAARKNSTLSITSNANNQPPAQVATP SQ PAQQQVRASSVNESESPASGPASGGNTAGSTPTSYHGSTGSTSGAVGGKSVIPIASAPPK SQ SAPGPGAGSMSRRDTISSKRQRRHSKSAGSDQPVSAGAVSSSGMDVDSPANSTGSNETMP SQ TFNPGGAFSGLPPTTQSSLGFGNGYINTPRPMVGPGGMMGMPNGQAGQMMGASSSSGPGS SQ GPSRTGAEWEWLTMSL XX SC SwissProt #P19212 XX SF 1 zinc finger motif XX FF activator of nitrogen-regulated genes XX MX M00142; F$NIT2_01 XX BS R02728; ASPN$NIAD_01; Quality: 2; Aspergillus nidulans (Emericella nidulans) BS R02729; ASPN$NIAD_02; Quality: 2; Aspergillus nidulans (Emericella nidulans) BS R02730; ASPN$NIAD_03; Quality: 2; Aspergillus nidulans (Emericella nidulans) BS R02731; ASPN$NIAD_04; Quality: 2; Aspergillus nidulans (Emericella nidulans) BS R02725; NEUCR$NIT3_01; Quality: 2; Neurospora crassa BS R02726; NEUCR$NIT3_02; Quality: 2; Neurospora crassa BS R02727; NEUCR$NIT3_03; Quality: 2; Neurospora crassa XX DR EMBL: M33956; NCNIT2(g). DR SwissProt: P19212; NIT2_NEUCR. DR PIR: A34755; A34755. XX RN [1] RA Fu Y.-H., Marzluf G. A. RT nit-2, the major positive-acting nitrogen regulatory RT gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein RL Proc. Natl. Acad. Sci. USA 87:5331-5335 (1990). XX // AC T00628 XX ID T00628 XX DT 15.10.92 (created); ewi. XX FA NLS1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R00084; MOUSE$ALBU_03; Quality: 6; mouse, Mus musculus XX RN [1] RA Herbst R. S., Friedman N., Darnell J. E., Babiss L. E. RT Positive and negative regulatory elements in the mouse albumin enhancer RL Proc. Natl. Acad. Sci. USA 86:1553-1557 (1989). XX // AC T00629 XX ID T00629 XX DT 20.11.92 (created); ewi. XX FA N-Oct-2alpha XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP nervous system XX RN [1] RA Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W., Fontana A. RT Astrocytes and glioblastoma cells express novel octamer-DNA RT binding proteins distinct from the ubiquitous Oct-1 RT and B cell type Oct-2 proteins RL Nucleic Acids Res. 18:5495-5503 (1990). XX // AC T00630 XX ID T00630 XX DT 20.11.92 (created); ewi. DT 08.08.96 (updated); ewi. XX FA N-Oct-3 XX SY Brain-2; Brn-2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; 3.1.2.3.2.1. XX SZ 443 AA; 46.9 kDa (cDNA) XX SQ MATAASNHYSLLTSSASIVHAEPPGAMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQ SQ WITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHG SQ PGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRTAAAAAHLPPS SQ MGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPP SQ PPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYG SQ NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTS SQ IEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLP SQ GAEDVYGGSRDTPPHHGVQTPVQ XX SC SwissProt #P20265 XX FT 68 90 glycine-rich region (22/23) FT 125 149 glutamine-rich region (24/25) FT 261 336 POU-specific domain FT 354 413 POU homeo domain FT 1 180 missing in Oct-5a [2]; FT 1 199 missing in Oct-5b [2]; XX SF usage of downstream translation initiation codons SF gives rise to N-Oct-5a and -b [2]; XX CP nervous system [2], small cell lung cancer (SCLC) cells [3]; XX MX M00145; V$BRN2_01 XX BS R04327; BRN2$CONS_01; Quality: 6 XX DR EMBL: Z11933; HSNOCTPOU(r). DR SwissProt: P20265; OC3N_HUMAN. DR PIR: S05043; S05043. DR PIR: S29334; S29334. XX RN [1] RA He X., Treacy M. N., Simmons D. M., Ingraham H. A., RA Swanson L. W., Rosenfeld M. G. RT Expression of a large family of POU-domain regulatory RT genes in mammalian brain development RL Nature 340:35-42 (1989). RN [2] RA Schreiber E., Tobler A., Malipiero U., Schaffner W., Fontana A. RT cDNA cloning of human N-Oct 3, a nervous-system specific RT POU domain transcripton factor binding to the octamer DNA motif RL Nucleic Acids Res. 21:253-258 (1993). RN [3] RA Schreiber E., Himmelmann A., Malipiero U., Tobler A., Stahel R., Fontana A. RT Human small cell lung cancer expresses the octamer RT DNA-binding and nervous system-specific transcription RT factor N-Oct 3 (Brain-2) RL Cancer Res. 52:6121-6124 (1992). RN [4] RA Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W., Fontana A. RT Astrocytes and glioblastoma cells express novel octamer-DNA RT binding proteins distinct from the ubiquitous Oct-1 RT and B cell type Oct-2 proteins RL Nucleic Acids Res. 18:5495-5503 (1990). XX // AC T00631 XX ID T00631 XX DT 20.11.92 (created); ewi. XX FA N-Oct-4 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP nervous system XX RN [1] RA Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W., Fontana A. RT Astrocytes and glioblastoma cells express novel octamer-DNA RT binding proteins distinct from the ubiquitous Oct-1 RT and B cell type Oct-2 proteins RL Nucleic Acids Res. 18:5495-5503 (1990). XX // AC T00632 XX ID T00632 XX DT 20.11.92 (created); ewi. DT 08.08.96 (updated); ewi. XX FA N-Oct-5a XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 3.1.2.3.2.2. XX SZ 263 AA; 28.7 kDa (cDNA) XX SQ MGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPP SQ PPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYG SQ NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTS SQ IEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLP SQ GAEDVYGGSRDTPPHHGVQTPVQ XX SC edited from SwissProt #P20265 XX FT 81 156 POU-specific domain FT 174 233 POU homeo domain XX SF variant of N-Oct-3, translated from a downstream translation SF initiation codon (Met-181 of N-Oct-3) [1]; XX CP nervous system XX RN [1] RA Schreiber E., Tobler A., Malipiero U., Schaffner W., Fontana A. RT cDNA cloning of human N-Oct 3, a nervous-system specific RT POU domain transcripton factor binding to the octamer DNA motif RL Nucleic Acids Res. 21:253-258 (1993). RN [2] RA Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W., Fontana A. RT Astrocytes and glioblastoma cells express novel octamer-DNA RT binding proteins distinct from the ubiquitous Oct-1 RT and B cell type Oct-2 proteins RL Nucleic Acids Res. 18:5495-5503 (1990). XX // AC T00633 XX ID T00633 XX DT 20.11.92 (created); ewi. DT 08.08.96 (updated); ewi. XX FA N-Oct-5b XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 3.1.2.3.2.3. XX SZ 244 AA; 26.8 kDa (cDNA) XX SQ MLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPH SQ SDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFK SQ NMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKP SQ SAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQ SQ TPVQ XX SC edited from SwissProt #P20265 XX FT 62 137 POU-specific domain FT 155 214 POU homeo domain XX SF generated by usage of a downstream translation initiation SF codon of the N-Oct-3 gene (Met-200) [1]; XX CP nervous system XX RN [1] RA Schreiber E., Tobler A., Malipiero U., Schaffner W., Fontana A. RT cDNA cloning of human N-Oct 3, a nervous-system specific RT POU domain transcripton factor binding to the octamer DNA motif RL Nucleic Acids Res. 21:253-258 (1993). RN [2] RA Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W., Fontana A. RT Astrocytes and glioblastoma cells express novel octamer-DNA RT binding proteins distinct from the ubiquitous Oct-1 RT and B cell type Oct-2 proteins RL Nucleic Acids Res. 18:5495-5503 (1990). XX // AC T00634 XX ID T00634 XX DT 20.11.92 (created); ewi. XX FA N-Oct-2beta XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP nervous system XX RN [1] RA Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W., Fontana A. RT Astrocytes and glioblastoma cells express novel octamer-DNA RT binding proteins distinct from the ubiquitous Oct-1 RT and B cell type Oct-2 proteins RL Nucleic Acids Res. 18:5495-5503 (1990). XX // AC T00635 XX ID T00635 XX DT 15.10.92 (created); ewi. DT 18.11.94 (updated); ewi. XX FA NP-III XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX FF repressor XX BS R02044; MOUSE$AFEP_13; Quality: 6; mouse, Mus musculus XX RN [1] RA Zhang D.-E., Ge X., Rabek J. P., Papaconstantinou J. RT Functional analysis of the trans-acting factor binding RT sites of the mouse alpha-fetoprotein proximal promoter RT by site-directed mutagenesis RL J. Biol. Chem. 266:21179-21185 (1991). RN [2] RA Zhang D.-E., Hoyt P. R., Papaconstantinou J. RT Localization of DNA Protein-binding Sites in the Proximal RT and Distal Promoter Regions of the Mouse alpha-Fetoprotein Gene RL J. Biol. Chem. 265:3382-3391 (1990). XX // AC T00636 XX ID T00636 XX DT 15.10.92 (created); ewi. DT 18.11.94 (updated); ewi. XX FA NP-IV XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R02043; MOUSE$AFEP_12; Quality: 6; mouse, Mus musculus XX RN [1] RA Zhang D.-E., Ge X., Rabek J. P., Papaconstantinou J. RT Functional analysis of the trans-acting factor binding RT sites of the mouse alpha-fetoprotein proximal promoter RT by site-directed mutagenesis RL J. Biol. Chem. 266:21179-21185 (1991). RN [2] RA Zhang D.-E., Hoyt P. R., Papaconstantinou J. RT Localization of DNA Protein-binding Sites in the Proximal RT and Distal Promoter Regions of the Mouse alpha-Fetoprotein Gene RL J. Biol. Chem. 265:3382-3391 (1990). XX // AC T00637 XX ID T00637 XX DT 09.12.92 (created); ewi. DT 12.07.94 (updated); hwi; ewi. XX FA NRF-1 XX SY nuclear respiratory factor 1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF activator, regulator of nuclear-encoded respiratory genes XX BS R02670; HS$QP_01; Quality: 6; human, Homo sapiens BS R02671; MOUSE$MRP_01; Quality: 6; mouse, Mus musculus BS R02223; NRF1$CONS; Quality: 6 BS R02669; RAT$COX6C2_01; Quality: 6; rat, Rattus norvegicus BS R02659; RAT$CYCS_02; Quality: 6; rat, Rattus norvegicus XX DR EMBL: L22454; HSNRF1(r). XX RN [1] RA Evans M. J., Scarpulla R. C. RT Interaction of Nuclear Factors with Multiple Sites RT in the Somatic Cytochrome c Promoter RL J. Biol. Chem. 264:14361-14368 (1989). RN [2] RA Evans M. J., Scarpulla R. C. RT NRF-1: a trans-activator of nuclear-encoded respiratory RT genes in animal cells RL Genes Dev. 4:1023-1034 (1990). XX // AC T00638 XX ID T00638 XX DT 15.10.92 (created); ewi. XX FA NTF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ approx. 90 kDa XX FF different from H2TF1, NF-kappaB or OTF XX BS R01683; MOUSE$IGH_41; Quality: 6; mouse, Mus musculus BS R02224; NTF$CONS; Quality: 6 XX RN [1] RA Yoza B. K., Roeder R. G. RT Identification of a novel factor that interacts with RT an immunoglobulin heavy-chain promoter and stimulates RT transcription in conjunction with the lymphoid cell-specific factor OTF2 RL Mol. Cell. Biol. 10:2145-2153 (1990). XX // AC T00639 XX ID T00639 XX DT 15.10.92 (created); ewi. XX FA OBF XX OS sea urchin OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida XX BS R00667; SP$H2B1_01; Quality: 6; sea urchin, Strongylocentrotus purpuratus BS R00670; SP$H2B1_04; Quality: 6; sea urchin, Strongylocentrotus purpuratus XX RN [1] RA Barberis A., Superti-Furga G., Busslinger M. RT Mutually Exclusive Interaction of the CCAAT-Binding RT Factor and of a Displacement Protein with Overlapping RT Sequences of a Histone Gene Promoter RL Cell 50:347-359 (1987). XX // AC T00640 XX ID T00640 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA (gamma)OBP XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO NF-A1, OTF-1 XX SQ MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS SQ LQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQ SQ LLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQ SQ QLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLQTQLPQQSQANLLQSQ SQ PSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRI SQ KLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDS SQ SLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK SQ EVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP SQ VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA SQ SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP SQ SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV SQ FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ SQ NSLFTVASASGAASTTTTASKAQ XX SC SwissProt #P14859 XX CP erythroid cells XX BS R00556; HS$GG_10; Quality: 6; human, Homo sapiens BS R01089; HS$M2DRA_04; Quality: 6; human, Homo sapiens XX DR EMBL: X13403; HSOCT1(r). DR SwissProt: P14859; OCT1_HUMAN. DR PIR: A31754; A31754. XX RN [1] RA Gumucio D. L., Rood K. L., Gray T. A., Riordan M. RA F., Sartor C. I., Collins F. S. RT Nuclear Proteins That Bind the Human gamma-Globin RT Gene Promoter: Alterations in Binding Produced by RT Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin RL Mol. Cell. Biol. 8:5310-5322 (1988). XX // AC T00641 XX ID T00641 XX DT 15.10.92 (created); ewi. DT 18.02.97 (updated); ewi. XX FA Oct-1 XX SY (Ig)NF-A; NF-A1; NF-III; OBP100; OTF-1; Oct-1B; TRF; alpha-H1; SY oct-B1A; oct-B1B; octamer-binding factor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; 3.1.2.2.1. XX SZ 743 AA; 76.5 kDa (cDNA), 90, 92, 95 kDa (SDS) XX SQ MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS SQ LQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQ SQ LLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQ SQ QLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLQTQLPQQSQANLLQSQ SQ PSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRI SQ KLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDS SQ SLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK SQ EVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP SQ VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA SQ SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP SQ SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV SQ FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ SQ NSLFTVASASGAASTTTTASKAQ XX SC SwissProt #P14859 XX FT 22 145 glutamine-rich region (31/124) FT 163 268 glutamine-rich region (32/106) FT 441 560 serine-/threonine-rich region (60/120) FT 275 289 acidic region (7/15) FT 287 312 POU-specific subdomain A FT 321 354 POU-specific subdomain B FT 281 354 POU-specific domain FT 379 438 POU homeo domain XX SF alternative splice variants [14]; SF the bipartite DNA-binding (POU) domain comprises a SF POU-specific (POUs) and a POU homeo (POUh) domain [64]; SF the homeo domain contains a recognizable helix-turn-helix SF motif [65], [64], [43]; SF the POU-specific domain comprises 4 alpha-helices SF connected by short loops, forming an internal hydrophobic SF core and representing an extended helix-turn-helix motif SF helix 1 and 4 form a parallel coiled coil, helix 3 SF acts as recognition helix and is part fo a structure SF that resembles that of bacteriophage repressors [40], [41], [43]; SF POUs contacts the 5'-half of the canonical ATGCAAAT, SF POUh the 3'-half [23], [43]; SF although not directly interacting within the molecule, SF POUs, POUh and the linker region in between together SF define the DNA-binding specificity of the whole POU domain [43], [33]; SF POUs induces DNA-bending [3]; SF KD for the canonical octamer element is 0.1 nM, whereas SF binding to the unrelated heptamer element (CTCATGA) has a KD of 20 nM [34]; SF interaction of two POU domains causes cooperative SF binding to adjacent octamer and heptamer elements [34]; SF another pattern recognized by Oct-1 is TAATGARAT, SF e. g. in the IE genes of HSV-1, frequently overlapping SF an octamer element [73], [60]; SF at this sequence, the complex depends on an intact SF POUh domain and also involves a viral activator (VP16) SF and one or two cellular components (C1 / HCF, C2) [23], [24]; SF in TAATGARAT, POUh contacts the 5'-half, the viral SF and/or C1 the 3'-half and 3' adjacent sequences [46], [51], [9], [24]; SF other reports describe the 3'-half to be contacted SF by the POUs domain with both POUs and POUh binding SF to DNA in the reverse order than on the normal octamer element [16]; SF this emphasizes the importance of the linker flexibility SF between POUs and POUh [43], [17]; SF only at the TAATGARAT elmeent, Oct-1 adopts the conformation SF that is suitable for VP16 interaction [44] through SF POUh helix 1 and 2 with Glu-400 discriminating against SF Oct-2 [36], [37], [39]; SF glutamine-rich N-terminal trans-activation domain [22]; SF transcriptionally inert C-terminus (contrasting to Oct-2) [22]; SF the second Glu-rich region activates only from binding SF sites that are proximal to te TATA box / initiation site [35]; SF direct interaction of POU with the C-terminal core domain of TBP [45]; XX CP ubiquitous [65]; XX FF transcriptional activator in the pol II [70] and in the pol III system [20]; FF also part of the replication machinery of adenovirus [7]; FF for stimulation of replication, the DNA-binding domain FF (whole POU domain) is required (POUs is inert, POUh FF inhibitory) and sufficient [8]; FF cooperative effects with Sp1 [28], PR and/or GR [29], OAP40 [31]; FF differentially phosphorylated during cell cycle [22], FF [84], [26], possibly by a p34cdc2-related protein FF kinase during mitosis with concomitant activation of histone H2B gene [84]; FF mitosis-specific phosphorylation within the POUh domain FF at Ser-385 is achieved in vitro by PKA and inhibits DNA-binding [26]; FF down-regulated by IFN-alpha or by TPA [27]; XX IN T00118; CFF; human, Homo sapiens. IN T00649; Oct-2; cat, Felis catus. IN T00650; Oct-2; rat, Rattus rattus. IN T00794; TBP; human, Homo sapiens. IN T00894; Vmw65; HSV-1, herpes simplex virus type 1. IN T01030; CCF; human, Homo sapiens. XX MX M00135; V$OCT1_01 MX M00136; V$OCT1_02 MX M00137; V$OCT1_03 MX M00138; V$OCT1_04 MX M00161; V$OCT1_05 MX M00162; V$OCT1_06 MX M00210; V$OCT_C MX M00248; V$OCT1_07 XX BS R01989; AD$E1A_13; Quality: 4; adenovirus type 5 BS R02001; AD$E1A_25; Quality: 4; adenovirus type 5 BS R01176; AD$ORI_02; Quality: 4; adenovirus type 4 BS R01177; AD$ORI_03; Quality: 2; adenovirus type 2 BS R03333; AS$OCT_01; Quality: 6 BS R03334; AS$OCT_02; Quality: 6 BS R03335; AS$OCT_03; Quality: 6 BS R00664; CHICK$H2B_01; Quality: 2; chick, Gallus gallus BS R03010; HBV$SA_03; Quality: 3; HBV, human hepatitis B virus BS R02571; HS$CMYC_10; Quality: 4; human, Homo sapiens BS R00549; HS$GG_03; Quality: 4; human, Homo sapiens BS R00551; HS$GG_05; Quality: 4; human, Homo sapiens BS R00557; HS$GG_11; Quality: 5; human, Homo sapiens BS R04196; HS$GG_37; Quality: 5; human, Homo sapiens BS R04197; HS$GG_38; Quality: 5; human, Homo sapiens BS R04200; HS$GG_41; Quality: 5; human, Homo sapiens BS R04201; HS$GG_42; Quality: 4; human, Homo sapiens BS R00662; HS$H2B_01; Quality: 2; human, Homo sapiens BS R00833; HS$IGH_01; Quality: 2; human, Homo sapiens BS R01635; HS$IGKL_03; Quality: 4; human, Homo sapiens BS R01638; HS$IGKL_06; Quality: 4; human, Homo sapiens BS R00932; HS$IL2_03; Quality: 5; human, Homo sapiens BS R00936; HS$IL2_07; Quality: 5; human, Homo sapiens BS R04234; HS$LYN_01; Quality: 4; human, Homo sapiens BS R01500; HS$U2SN_06; Quality: 2; human, Homo sapiens BS R00810; HSV1$IE1_01; Quality: 4; HSV-1, herpes simplex virus type 1 BS R01917; HSV1$IE1_03; Quality: 4; HSV-1, herpes simplex virus type 1 BS R00812; HSV1$IE2_01; Quality: 4; HSV-1, herpes simplex virus type 1 BS R02732; HSV1$IE2_02; Quality: 5; HSV-1, herpes simplex virus type 1 BS R02733; HSV1$IE2_03; Quality: 5; HSV-1, herpes simplex virus type 1 BS R00814; HSV1$IE3_02; Quality: 4; HSV-1, herpes simplex virus type 1 BS R00815; HSV1$IE3_03; Quality: 4; HSV-1, herpes simplex virus type 1 BS R00820; HSV1$IE3_08; Quality: 4; HSV-1, herpes simplex virus type 1 BS R00824; HSV1$IE4_02; Quality: 4; HSV-1, herpes simplex virus type 1 BS R01734; MOUSE$B29_01; Quality: 4; mouse, Mus musculus BS R00838; MOUSE$IGH_04; Quality: 4; mouse, Mus musculus BS R00842; MOUSE$IGH_08; Quality: 2; mouse, Mus musculus BS R00843; MOUSE$IGH_09; Quality: 2; mouse, Mus musculus BS R00869; MOUSE$IGH_35; Quality: 4; mouse, Mus musculus BS R00872; MOUSE$IGH_38; Quality: 3; mouse, Mus musculus BS R01682; MOUSE$IGH_40; Quality: 2; mouse, Mus musculus BS R00888; MOUSE$IGKL_12; Quality: 2; mouse, Mus musculus BS R00890; MOUSE$IGKL_14; Quality: 4; mouse, Mus musculus BS R00891; MOUSE$IGKL_15; Quality: 4; mouse, Mus musculus BS R00892; MOUSE$IGKL_16; Quality: 4; mouse, Mus musculus BS R00893; MOUSE$IGKL_17; Quality: 4; mouse, Mus musculus BS R01778; MOUSE$IGKL_20; Quality: 4; mouse, Mus musculus BS R01779; MOUSE$IGKL_21; Quality: 4; mouse, Mus musculus BS R01780; MOUSE$IGKL_22; Quality: 4; mouse, Mus musculus BS R03426; MOUSE$IGKL_25; Quality: 4; mouse, Mus musculus BS R03427; MOUSE$IGKL_26; Quality: 4; mouse, Mus musculus BS R02953; MOUSE$IL2_05; Quality: 1; mouse, Mus musculus BS R03383; MOUSE$JUND_03; Quality: 4; mouse, Mus musculus BS R02225; OCT1$CONS; Quality: 6 BS R00666; PM$H2BA_02; Quality: 2; sea urchin, Pseudocentrotus miliaris BS R03417; PRV$IE_02; Quality: 5; pseudorabies virus BS R03418; PRV$IE_03; Quality: 5; pseudorabies virus BS R03419; PRV$IE_04; Quality: 5; pseudorabies virus BS R03420; PRV$IE_05; Quality: 5; pseudorabies virus BS R01388; SV$SV40_20; Quality: 2; SV40, simian virus 40 BS R01389; SV$SV40_21; Quality: 3; SV40, simian virus 40 BS R01396; SV$SV40_28; Quality: 2; SV40, simian virus 40 BS R01399; SV$SV40_31; Quality: 4; SV40, simian virus 40 BS R01400; SV$SV40_32; Quality: 4; SV40, simian virus 40 BS R01401; SV$SV40_33; Quality: 4; SV40, simian virus 40 BS R01504; XENLA$U2SN_10; Quality: 2; clawed frog, Xenopus laevis XX DR EMBL: X13403; HSOCT1(r). DR EMBL: S75007; S75007(g). DR SwissProt: P14859; OCT1_HUMAN. DR PIR: A31754; A31754. DR Compel: C00039 DR Compel: C00048 DR PDB: 1pog; OCT-1 POU HOMEODOMAIN DNA-BINDING PROTEIN MUTANT (INS(RGSHM-R6),INS(I66-DI) HOMO SAPIENS. XX RN [1] RA Spector D., Purves F., Roizman B. RT Role of alpha-transducing factor (VP16) in the induction RT of alpha genes within the context of viral genomes RL J. Virol. 65:3504-3513 (1991). RN [2] RA Hoegbom E., Magnusson A.-C., Leanderson T. RT Functional modularity in the SP6 kappa promoter RL Nucleic Acids Res. 19:4347-4354 (1991). RN [3] RA Verrijzer C. P., van Oosterhout J. A. W. M., van Weperen RA W. W., van der Vliet P. C. RT POU proteins bend DNA via the POU-specific domain RL EMBO J. 10:3007-3014 (1991). RN [4] RA Pruijn G. J. M., van der Vliet P. C., Dathan N. A., Mattaj I. W. RT Anti-OTF-1 antibodies inhibit NFIII stimulation of RT in vitro adenovirus DNA replication RL Nucleic Acids Res. 17:1845-1863 (1989). RN [5] RA O'Neill E. A., Kelly T. J. RT Purification and Characterization of Nuclear Factor RT III (Origin Recognition Protein C), a Sequence-specific RT DNA Binding Protein Required for Efficient Initiation RT of Adenovirus DNA Replication RL J. Biol. Chem. 263:931-937 (1988). RN [6] RA Stimac E., Lyons S., Pious D. RT Transcription of HLA Class II Genes in the Absence RT of B-Cell-Specific Octamer-Binding Factor RL Mol. Cell. Biol. 8:3734-3739 (1988). RN [7] RA O'Neill E. A., Fletcher C., Burrow C. R., Heintz N., RA Roeder R. G., Kelly T. J. RT Transcription factor OTF-1 is functionally identical RT to the DNA replication factor NF-III RL Science 241:1210-1213 (1988). RN [8] RA Verrijzer C. P., Kal A. J., van der Vliet P. C. RT The DNA binding domain (POU domain) of transcription RT factor oct-1 suffices for stimulation of DNA replication RL EMBO J. 9:1883-1888 (1990). RN [9] RA Greaves R. F., O'Hare P. RT Sequence, function, and regulation of the Vmw65 gene RT of herpes simplex virus type 2 RL J. Virol. 65:6705-6713 (1991). RN [10] RA Rosales R., Vigneron M., Macchi M., Davidson I., Xiao J. H., Chambon P. RT In vitro binding of cell-specific and ubiquitous nuclear RT proteins to the octamer motif of the SV40 enhancer RT and related motifs present in other promoters and enhancers RL EMBO J. 6:3015-3025 (1987). RN [11] RA Nelms K., Van Ness B. RT Identification of an Octamer-Binding Site in the Human RT Kappa Light-Chain Enhancer RL Mol. Cell. Biol. 10:3843-3846 (1990). RN [12] RA Martin D. J., van Ness B. G. RT Initiation and Processing of Two Kappa Immunoglobulin RT Germ Line Transcripts in Mouse B Cells RL Mol. Cell. Biol. 10:1950-1958 (1990). RN [13] RA Yoza B. K., Roeder R. G. RT Identification of a novel factor that interacts with RT an immunoglobulin heavy-chain promoter and stimulates RT transcription in conjunction with the lymphoid cell-specific factor OTF2 RL Mol. Cell. Biol. 10:2145-2153 (1990). RN [14] RA Das G., Herr W. RT Enhanced activation of the human histone H2B promoter RT by an Oct-1 variant generated by alternative splicing RL J. Biol. Chem. 268:25026-25032 (1993). RN [15] RA Kristie T. M., Sharp P. A. RT Purification of the cellular C1 factor required for RT the stable recognition of the Oct-1 homeodomain by RT the herpes simplex virus alpha-trans-induction factor (VP16) RL J. Biol. Chem. 268:6525-6534 (1993). RN [16] RA Cleary M. A., Herr W. RT Mechanisms for flexibility in DNA sequence recognition RT and VP16-induced complex formation by the Oct-1 POU domain RL Mol. Cell. Biol. 15:2090-2100 (1995). RN [17] RA Herr W., Cleary M. A. RT The POU domain: versatility in tanscriptional regulation RT by a flexible two-in-one DNA-binding domain RL Genes Dev. 9:1679-1693 (1995). RN [18] RA Goldsborough A., Ashworth A., Willison K. R. RT Cloning and sequencing of POU-boxes expressed in mouse testis RL Nucleic Acids Res. 18:1634-1634 (1990). RN [19] RA Sturm R. A. RT An STS in the human oct-1 gene located on chromosome 1 RL Nucleic Acids Res. 19:6963-6963 (1991). RN [20] RA Murphy S., Pierani A., Scheidereit C., Melli L., Roeder R. G. RT Purified octamer binding transcription factors stimulate RT RNA polymerase III-mediated transcription of the 7SK RNA gene RL Cell 59:1071-1080 (1989). RN [21] RA Xiao P., Capone J. P. RT A cellular factor binds to the herpes simplex virus RT type 1 transactivator Vmw65 and is required for Vmw65-dependent RT protein-DNA complex assembly with Oct-1 RL Mol. Cell. Biol. 10:4974-4977 (1990). RN [22] RA Tanaka M., Herr W. RT Differential transcriptional activation by Oct-1 and RT Oct-2: interdependent activation domains induce Oct-2 phosphorylation RL Cell 60:375-386 (1990). RN [23] RA Verrijzer C. P., Kal A. J., van der Vliet P. C. RT The oct-1 homeo domain contacts only part of the octamer RT sequence and full oct-1 DNA-binding activity requires RT the POU-specific domain RL Genes Dev. 4:1964-1974 (1990). RN [24] RA Kristie T. M., Sharp P. A. RT Interactions of the Oct-1 POU subdomains with specific RT DNA sequences and with the HSV a-trans-activator protein RL Genes Dev. 4:2382-2396 (1990). RN [25] RA Dent C. L., Latchman D. S. RT The overlapping octamer/TAATGARAT motif is a high-affinity RT binding site for the cellular transcription factors Oct-1 and Oct-2 RL Biochem. J. 277:541-545 (1991). RN [26] RA Segil N., Roberts S. B., Heintz N. RT Mitotic phosphorylation of the Oct-1 homeodomain and RT regulation of Oct-1 DNA binding activity RL Science 254:1814-1816 (1991). RN [27] RA Dent C. L., Lillycrop K. A., Bybee A., Latchman D. S., Thomas N. S. B. RT Interferon-a treatment of Daudi cells down-regulates RT the octamer binding transcription/DNA replication factors Oct-1 and Oct-2 RL J. Biol. Chem. 266:20888-20892 (1991). RN [28] RA Janson L., Petersson U. RT Cooperative interactions between transcription factors Sp1 and OTF-1 RL Proc. Natl. Acad. Sci. USA 87:4732-4736 (1990). RN [29] RA BrĘggemeier U., Kalff M., Franke S., Scheidereit C., Beato M. RT Ubiquitous transcription factor OTF-1 mediates induction RT of the MMTV promoter through synergistic interaction with hormone receptors RL Cell 64:565-572 (1991). RN [30] RA Stern S., Herr W. RT The herpes simplex virus trans-activator VP16 recognizes RT the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain RL Genes Dev. 5:2555-2566 (1991). RN [31] RA Ullmann K. S., Flanagan W. M., Edwards C. A., Crabtree G. R. RT Activation of early gene expression in T lymphocytes RT by Oct-1 and an inducible protein, OAP40 RL Science 254:558-562 (1991). RN [32] RA Tanaka M., Lai J.-S., Herr W. RT Promoter-selective activation domains in Oct-1 and RT Oct-2 direct differential activation of an snRNA and mRNA promoter RL Cell 68:755-767 (1992). RN [33] RA Aurora R., Herr W. RT Segments of the POU domain influence one another's DNA-binding specificity RL Mol. Cell. Biol. 12:455-467 (1992). RN [34] RA Verrijzer C. P., van Oosterhout J. A. W. M., van der Vliet P. C. RT The Oct-1 POU domain mediates interactions between RT Oct-1 and other POU proteins RL Mol. Cell. Biol. 12:542-551 (1992). RN [35] RA Seipel K., Georgiev O., Schaffner W. RT Different activation domains stimulte transcription RT from remote ('enhancer') and proximal ('promoter') positions RL EMBO J. 11:4961-4968 (1992). RN [36] RA Lai J.-S., Cleary M. A., Herr W. RT A single amino acid exchange transfers VP16-induced RT positive control from the Oct-1 to the Oct-2 homeo domain RL Genes Dev. 6:2058-2065 (1992). RN [37] RA Pomerantz T. M., L Kristie J., Sharp P. A. RT Recognition of the surface of a homeo domain protein RL Genes Dev. 6:2047-2057 (1990). RN [38] RA Wilson A. C., LaMarco K., Peterson M. G., Herr W. RT The VP16 accessory protein HCF is a family of polypeptides RT processed from a large precursor protein RL Cell 74:115-125 (1993). RN [39] RA Cleary M. A., Stern S., Tanaka M., Herr W. RT Differential positive control by Oct-1 and Oct-2: RT activation of a transcriptionally silent motif through RT Oct-1 and VP16 corecruitment RL Genes Dev. 7:72-83 (1993). RN [40] RA Assa-Munt N., Mostishire-Smith R. J., Aurora R., Herr W., Wright P. E. RT The solution structure of the Oct-1 POU-specific domain RT reveals a striking similarity to the bacteriophage RT l repressor DNA-binding domain RL Cell 73:193-205 (1993). RN [41] RA Dekker N., Cox M., Boelens R., Verrijzer C. P., van der Vliet P. C. RT Solution structure of the POU-specific domain of Oct-1 RL Nature 362:852-855 (1993). RN [42] RA Coenjaerts F. E. J., van Oosterhout J. A. W. M., van der Vliet P. C. RT The Oct-1 POU domain stimulates adenovirus DNA replication RT by a direct interaction between the viral precursor RT terminal protein-DNA polymerase complex and the POU homeodomain RL EMBO J. 13:5401-5409 (1994). RN [43] RA Klemm J. D., Rould M. A., Aurora R., Herr W., Pabo C. O. RT Crytsal structure of the Oct-1 POU domain bound to RT an octamer site: DNA recognition with tethered DNA-binding modules RL Cell 77:21-32 (1994). RN [44] RA Walker S., Hayes S., O'Hare P. RT Site-specific conformational alteration of the Oct-1 RT POU-domain-DNA complex as the basis for differential RT recognition by Vmw65 (VP16) RL Cell 79:841-852 (1994). RN [45] RA Zwilling S., Annweiler A., Wirth T. RT The POU domains of the Oct1 and Oct2 transcription RT factors mediate specific interaction with TBP RL Nucleic Acids Res. 22:1655-1662 (1994). RN [46] RA Goding C. R., O'Hare P. RT Herpes simplex virus Vmw65-octamer binding protein RT interaction: a paradigm for combinatorial control of transcription RL Virology 173:363-367 (1989). RN [47] RA Currie R. A., Roeder R. G. RT Identification of an Octamer-Binding Site in the Mouse RT Kappa Light-Chain Immunoglobulin Enhancer RL Mol. Cell. Biol. 9:4239-4247 (1989). RN [48] RA Lloyd J. A., Lee R. F., Lingrel L. B. RT Mutations in two regions upstream of the Agamma globin RT gene canonical promoter affect gene expression RL Nucleic Acids Res. 17:4339-4352 (1989). RN [49] RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P. RT Octamer binding proteins confer transcriptional activity RT in early mouse embryogenesis RL EMBO J. 8:2551-2557 (1989). RN [50] RA Shibuya H., Taniguchi T. RT Identification of multiple cis-elements and trans-acting RT factors involved in the induced expression of human IL-2 gene RL Nucleic Acids Res. 17:9173-9184 (1989). RN [51] RA Kristie T. M., LeBovitz J. H., Sharp P. A. RT The octamer-binding proteins form multi-protein-DNA RT complexes with the HSV alphaTIF regulatory protein RL EMBO J. 8:4229-4238 (1989). RN [52] RA Mantovani R., Malgarettie N., Nicolis S., Ronchi A., RA Giglioni B., Ottolenghi S. RT The effects of HPFH mutations in the human gamma-globin RT promoter on binding of ubiquitous and erythroid specific nuclear factors RL Nucleic Acids Res. 16:7783-7797 (1988). RN [53] RA Catala F., deBoer E., Habets G., Grosveld F. RT Nuclear protein factors and erythroid transcription RT of the human Agamma-globin gene RL Nucleic Acids Res. 17:3811-3827 (1989). RN [54] RA Broggini M., Ponti M., Ottolenghi S., D'Incalci M., RA Mongelli N., Mantovani R. RT Distamycins inhibit the binding of OTF-1 and NFE-1 RT transfactors to their conserved DNA elements RL Nucleic Acids Res. 17:1051-1059 (1989). RN [55] RA Katan M., Haigh A., Verrijzer C. P., van der Vliet P. C., O'Hare P. RT Characterization of a cellular factor which interacts RT functionally with Oct-1 in the assembly of a multicomponent RT transcription complex RL Nucleic Acids Res. 18:6871- (1990). RN [56] RA Sive H. L., Roeder R. G. RT Interaction of a common factor with conserved promoter RT and enhancer sequences in histone H2B, immunoglobulin, RT and U2 small nuclear RNA (snRNA) genes RL Proc. Natl. Acad. Sci. USA 83:6382-6386 (1986). RN [57] RA Fletcher C., Heintz N., Roeder R. G. RT Purification and Characterization of OTF-1, a Transcription RT Factor Regulating Cell Cycle Expression of a Human Histone H2b Gene RL Cell 51:773-781 (1987). RN [58] RA Kemler I., Schreiber E., Mueller M. M., Matthias P., Schaffner W. RT Octamer transcription factors bind to two different RT sequence motifs of the heavy chain promoter RL EMBO J. 8:2001-2008 (1989). RN [59] RA Zhou D.-X., Yen T. S. B. RT The ubiquitous transcription factor Oct-1 and the RT liver-specific factor HNF-1 are both required to activate RT transcription of a hepatitis B virus promoter RL Mol. Cell. Biol. 11:1353-1359 (1991). RN [60] RA Gerster T., Roeder R. G. RT A herpesvirus trans-activating protein interacts with RT transcription factor OTF-1 and other cellular proteins RL Proc. Natl. Acad. Sci. USA 85:6347-6351 (1988). RN [61] RA O'Hare P., Goding C. R. RT Herpes Simplex Virus Regulatory Elements and the Immunoglobulin RT Octamer Domain Bind a Common Factor and Are Both Targets RT for Virion Transactivation RL Cell 52:435-445 (1988). RN [62] RA Kristie T. M., Roizman B. RT Host cell proteins bind to the cis-acting site required RT for virion-mediated induction of herpes simplex virus 1 alpha genes RL Proc. Natl. Acad. Sci. USA 84:71-75 (1987). RN [63] RA McKnight J. L. C., Kristie T. M., Roizman B. RT Binding of the virion protein mediating alpha gene RT induction in herpes simplex virus 1-infected cells RT to its cis site requires cellular proteins RL Proc. Natl. Acad. Sci. USA 84:7061-7065 (1987). RN [64] RA Sturm R. A., Herr W. RT The POU domain is a bipartite DNA-binding structure RL Nature 336:601-604 (1988). RN [65] RA Sturm R. A., Das G., Herr W. RT The ubiquitous octamer-binding protein Oct-1 contains RT a POU domain with a homeo box subdomain RL Genes Dev. 2:1582-1599 (1988). RN [66] RA Stern S., Tanaka M., Herr W. RT The Oct-1 homoeodomain directs formation of a multiprotein-DNA RT complex with the HSV transactivator VP16 RL Nature 341:624-630 (1989). RN [67] RA Wang J., Nishiyama K., Araki K., Kitamura D., Watanabe T. RT Purification of an octamer sequence (ATGCAAAT)-binding RT protein from human B cells RL Nucleic Acids Res. 15:10105-10116 (1987). RN [68] RA Preston C. M., Frame M. C., Campbell M. E. M. RT A Complex formed between Cell Components and an HSV RT Structural Polypeptide Binds to a Viral Immediate RT Early Gene Regulatory DNA Sequence RL Cell 52:425-434 (1988). RN [69] RA Staudt L. M., Singh H., Sen R., Wirth T., Sharp P. A., Baltimore D. RT A lymphoid-specific protein binding to the octamer RT motif of immunoglobulin genes RL Nature 323:640-643 (1986). RN [70] RA LeBowitz J. H., Kobayashi T., Staudt L., Baltimore D., Sharp P. A. RT Octamer-binding proteins from B or HeLa cells stimulate RT transcription of the immunoglobulin heavy-chain promoter in vitro RL Genes Dev. 2:1227-1237 (1988). RN [71] RA Poellinger L., Roeder R. G. RT Octamer transcription factors 1 and 2 each bind to RT two different functional elements in the immunoglobulin heavy-chain promoter RL Mol. Cell. Biol. 9:747-756 (1989). RN [72] RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). RN [73] RA Xiao J. H., Davidson I., Ferrandon D., Rosales R., RA Vigneron M., Macchi M., Ruffenach F., Chambon P. RT One cell-specific and three ubiquitous proteins bind RT in vitro to overlapping motifs in the domain B1 of the SV40 enhancer RL EMBO J. 6:3005-3013 (1987). RN [74] RA Bohmann D., Keller W., Dale T., Schoeler H. R., Tebb G., Mattaj I. W. RT A transcription factor which binds to the enhancers RT of SV40, immunoglobulin heavy chain and U2 snRNA genes RL Nature 325:268-272 (1987). RN [75] RA Schreiber E., Matthias P., Mueller M. M., Schaffner W. RT Identification of a novel lymphoid specific octamer RT binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA) RL EMBO J. 7:4221-4229 (1988). RN [76] RA Sturm R., Baumruker T., Franza Jr. B. R., Herr W. RT A 100-kD HeLa cell octamer binding protein (OBP100) RT interacts differently with two separate octamer-related RT sequences within the SV40 enhancer RL Genes Dev. 1:1147-1160 (1987). RN [77] RA Scheidereit C., Heguy A., Roeder R. G. RT Identification and Purification of a Human Lymphoid-Specific RT Octamer-Binding Protein (OTF-2) That Activates Transcription RT of an Immunoglobulin Promoter In Vitro RL Cell 51:783-793 (1987). RN [78] RA Staudt L. M., Clerc R. G., Singh H., LeBowitz J. H., RA Sharp P. A., Baltimore D. RT Cloning of a lymphoid-specific cDNA encoding a protein RT binding the regulatory octamer DNA motif RL Science 241:577-580 (1988). RN [79] RA Pruijn G. J. M., van Driel W., van Miltenburg R. T., van der Vliet P. C. RT Promoter and enhancer elements containing a conserved RT sequence motif are recognized by nuclear factor III, RT a protein stimulating adenovirus DNA replication RL EMBO J. 6:3771-3778 (1987). RN [80] RA Baumruker T., Sturm R., Herr W. RT OBP100 binds remarkably degenerate octamer motifs RT through specific interactions with flanking sequences RL Genes Dev. 2:1400-1413 (1988). RN [81] RA Ho I.-C., Bhat N. K., Gottschalk L. R., Lindsten R., RA Thompson C. B., Papas T. S., Leiden J. M. RT Sequence-specific binding of human Ets-1 to the T RT cell receptor alpha gene enhancer RL Science 250:814-818 (1990). RN [82] RA Kamps M. P., Corcoran L., LeBowitz J. H., Baltimore D. RT The promoter of the human interleukin-2 gene contains RT two octamer-binding sites and is partially activated RT by the expression of Oct-2 RL Mol. Cell. Biol. 10:5464-5472 (1990). RN [83] RA Mul Y. M., Verrijzer C. P., van der Vliet P. C. RT Transcription factors NFI and NFIII/oct-1 function RT independently, employing different mechanisms to enhance RT adenovirus DNA replication RL J. Virol. 64:5510-5518 (1990). RN [84] RA Roberts S. B., Segil N., Heintz N. RT Differential phosphorylation of the transcription RT factor Oct1 during cell cycle RL Science 253:1022-1026 (1991). XX // AC T00642 XX ID T00642 XX DT 15.10.92 (created); ewi. DT 01.08.96 (updated); ewi. XX FA Oct-1 XX SY (Ig)NF-A; NF-A1; NF-III; OBP100; OTF-1; TRF; alpha-H1; oct-B1A; SY oct-B1B; octamer-binding factor; XX OS clawed frog, Xenopus laevis OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CL C0007; POU; 3.1.2.2.1. XX SZ 100 kDa (SDS) XX SQ MKLHSSSKIQNHAWLSDARMNNPSETSKSPESGDGNTGTQTNGLDFQKQAVPIGAITSAQ SQ AQALLGHLHQVQLAGTSLQAAAHSLNVQTKFKEEPGEPMQVVQPSQQPSLQAAIPQTQLM SQ VAGGQIAGLTLTPAQQQMLLQQAQAQLLAAAVQHSANQQHNAAGATISASAATPMTQIPL SQ SQPIQIAQDLQQLQQLQQQNLNLQQYVLVHPTTNLQSAQFIISQTPQGQQGLLQAQNLLT SQ QLPQQSQANLLQSQPSITLTSQPATPTRTIAATPVQQLPQSQTTPKRIDTPSLEEPSDLE SQ ELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLL SQ EKWLNDAVLENITSDSTLTNQSVLNSPGHGMEGLNRRRKKRTSIETNIRVALEKSFLENQ SQ KPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGSSSSPIKSLFSSPNPLVA SQ STPSLVTSSPATTLTVNPVLPLTSAAAITSFHIPGTTGTSSANTATVISTAPPVSSVLTS SQ PSLSSSPSATAASSEASTAGETSTTQTTSTPMTSSLNTGQVMVTASGIHTAAATALQGAA SQ QLPTNASLAAMAAAAGLNPGLMAPSQFAAGGALFSLNPGALGSALSPALMSNSTLATIQA SQ LASSGSLPITSLDAAGNLVFANAGGTPNIVTAPLFLNPQNLSLFTSNPVSLISAASAGAT SQ GPITSLHATTSSIDSIQNALFTMASASGAASTTTSASKAQ XX SC SwissProt #P16143 XX FT 295 368 POU-specific domain FT 301 326 POU-specific subdomain A FT 335 368 POU-specific subdomain B FT 397 456 POU homeo domain FT 40 159 glutamine-rich region (27/120) FT 177 282 glutamine-rich region (32/106) FT 289 303 acidic region (7/15) FT 459 590 serine-/threonine-rich region (60/132) XX CP (kidney) XX IN T00649; Oct-2; cat, Felis catus. IN T00650; Oct-2; rat, Rattus rattus. IN T00894; Vmw65; HSV-1, herpes simplex virus type 1. IN T01030; CCF; human, Homo sapiens. XX MX M00135; V$OCT1_01 MX M00136; V$OCT1_02 MX M00137; V$OCT1_03 MX M00138; V$OCT1_04 MX M00161; V$OCT1_05 MX M00162; V$OCT1_06 MX M00210; V$OCT_C MX M00248; V$OCT1_07 XX BS R04221; XENLA$H2B_03; Quality: 4; clawed frog, Xenopus laevis BS R02382; XENLA$OCR_01; Quality: 4; clawed frog, Xenopus laevis XX DR EMBL: X17190; XLOCT1(r). DR EMBL: X51819; XLXOCT(g). DR SwissProt: P16143; OCT1_XENLA. DR PIR: S07896; S07896. XX RN [1] RA Baltzinger M., Stiegler P., Remy P. RT Cloning and sequencing of POU-boxes expressed in Xenopus RT laevis neurula embryos RL Nucleic Acids Res. 18:6131-6131 (1990). RN [2] RA Smith D. P., Old R. W. RT Nucleotide sequence of Xenopus laevis Oct-1 cDNA RL Nucleic Acids Res. 18:369 (1990). XX // AC T00643 XX ID T00643 XX DT 27.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA Oct-1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 3.1.2.2.1. XX SZ 90-100 kDa (SDS) XX SQ GDVGLAMGKLYGNDFSQTTISRFESLNLSFKNMCKLKPLLESWLNDAENLSSDSTASLPS SQ ALNSPGLGAEGLNRRSKKRTSIETNIRWSLEKSFMENQKPTSEDITLIAEQLNMEKEVIR XX SC SwissProt #P31503 XX SF phosphorylation XX FF differential phosphorylation during cell cycle XX IN T00646; Oct-2.1; human, Homo sapiens. IN T00647; Oct-2; human, Homo sapiens. IN T00648; Oct-2; mouse, Mus musculus. IN T00649; Oct-2; cat, Felis catus. IN T00650; Oct-2; rat, Rattus rattus. IN T00894; Vmw65; HSV-1, herpes simplex virus type 1. IN T01030; CCF; human, Homo sapiens. IN T01032; Oct-2; chick, Gallus gallus. IN T01864; Oct-2.1; mouse, Mus musculus. IN T01865; Oct-2.3; mouse, Mus musculus. IN T01866; Oct-2.4; mouse, Mus musculus. IN T01867; Oct-2.6; mouse, Mus musculus. IN T01870; Oct-2.1; rat, Rattus rattus. XX MX M00135; V$OCT1_01 MX M00136; V$OCT1_02 MX M00137; V$OCT1_03 MX M00138; V$OCT1_04 MX M00161; V$OCT1_05 MX M00162; V$OCT1_06 MX M00210; V$OCT_C MX M00248; V$OCT1_07 XX BS R00815; HSV1$IE3_03; Quality: 3; HSV-1, herpes simplex virus type 1 BS R02225; OCT1$CONS; Quality: 6 XX DR EMBL: X59429; RNOCT1MR(r). DR SwissProt: P31503; OCT1_RAT. DR PIR: S19093; S19093. DR Compel: C00047 XX RN [1] RA Herr W., Cleary M. A. RT The POU domain: versatility in tanscriptional regulation RT by a flexible two-in-one DNA-binding domain RL Genes Dev. 9:1679-1693 (1995). RN [2] RA Kambe F., Tsukahara S., Kato T., Seo H. RT The POU-domain protein Oct-1 is widely expressed in adult rat organs RL Biochim. Biophys. Acta 1171:307-310 (1993). RN [3] RA Lillycrop K. A., Latchman D. S. RT Cloning and sequencing of the rat Oct-1 POU box RL Nucleic Acids Res. 19:3744-3744 (1991). RN [4] RA He X., Treacy M. N., Simmons D. M., Ingraham H. A., RA Swanson L. W., Rosenfeld M. G. RT Expression of a large family of POU-domain regulatory RT genes in mammalian brain development RL Nature 340:35-42 (1989). XX // AC T00644 XX ID T00644 XX DT 15.10.92 (created); ewi. DT 02.08.96 (updated); ewi. XX FA Oct-1A XX SY IgNF-A; NF-A; NF-A1; NF-III; OBP100; OTF-1; Oct-1; TRF; alpha-H1; SY oct-B1A; oct-B1B; octamer-binding factor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.2.2.1.1. XX SZ 770 AA; 79.5 kDa (cDNA), 90-100 kDa (SDS) XX SQ MNNPSETNKSSMESEDASTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS SQ LQAAAQSLNVQSKSSEESGDSQQSSQPSSQPPSVQSAIPQTQLMLAGGQITGLTLTPAQQ SQ QLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQL SQ QQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQP SQ QPSITLTSQPTTPTRTIAAASVQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRR SQ IKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSD SQ STASSPSALNSPGLGAEGLNRRRKKRTSIETNIRVALEKSFMENQKPTSEDITLIAEQLN SQ MEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPASLVATTPSLVTSSTATTLT SQ VNPVLPLTSAAVTNLSLTDQDLRRGCSWEVLRSLPDRVTTTAGTTDSTSNNNTATVISTA SQ PPASSAVTSPSLSPSPSASASTSEASSASETNTTQTTSTPLPSPLGASQVMVTTPGLQTA SQ AAALQGAGQLPANASLAAMAAAAGLSPGLMAPSQFAAGGALLSLSPGTLGSALSPALMSN SQ STLATIQALASSGSLPITSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLV SQ SAAAASTGNSAPTASLHASSTSTESIQSSLFTVASASGPASTTTAASKAQ XX SC SwissProt #P25425 XX FT 22 146 glutamine-rich region (30/125) FT 164 269 glutamine-rich region (31/106) FT 276 290 acidic region (7/15) FT 444 579 serine-/threonine-rich region (59/136) FT 499 522 missing in Oct-1B and Oct-1C [8]; FT 717 770 replaced by 693-701 in Oct-1C [8]; FT 282 355 POU-specific domain FT 382 441 POU homeo domain XX SF at least 3 splice variants are encoded by the murine oct-1 gene [8]; SF compared to the human homolog, mouse Oct-1 exhibits SF four AA exchanges within helix 1 and 2 making its SF sequence more similar to (human) Oct-2 and thus causing SF a much weaker interaction with VP16 [8], [10]; SF homeo domain essential for GR interaction [2]; XX CP ubiquitous [11]; XX FF DNA-binding is reduced by GR in a ligand-dependent manner [2]; XX IN T00333; GR; rat, Rattus norvegicus. IN T00337; GR alpha; human, Homo sapiens. IN T00649; Oct-2; cat, Felis catus. IN T00650; Oct-2; rat, Rattus rattus. IN T00894; Vmw65; HSV-1, herpes simplex virus type 1. IN T01030; CCF; human, Homo sapiens. IN T01920; GR beta; human, Homo sapiens. XX MX M00135; V$OCT1_01 MX M00136; V$OCT1_02 MX M00137; V$OCT1_03 MX M00138; V$OCT1_04 MX M00161; V$OCT1_05 MX M00162; V$OCT1_06 MX M00210; V$OCT_C MX M00248; V$OCT1_07 XX BS R03333; AS$OCT_01; Quality: 6 BS R03334; AS$OCT_02; Quality: 6 BS R03335; AS$OCT_03; Quality: 6 BS R00810; HSV1$IE1_01; Quality: 2; HSV-1, herpes simplex virus type 1 BS R02824; MOUSE$CABL1_01; Quality: 4; mouse, Mus musculus BS R00303; MOUSE$E1_01; Quality: 4; mouse, Mus musculus BS R00304; MOUSE$E1_02; Quality: 4; mouse, Mus musculus BS R00305; MOUSE$E1_03; Quality: 4; mouse, Mus musculus BS R00306; MOUSE$E1_04; Quality: 4; mouse, Mus musculus BS R00864; MOUSE$IGH_30; Quality: 4; mouse, Mus musculus BS R00870; MOUSE$IGH_36; Quality: 4; mouse, Mus musculus BS R00872; MOUSE$IGH_38; Quality: 2; mouse, Mus musculus BS R01884; MOUSE$IGH_44; Quality: 5; mouse, Mus musculus BS R01885; MOUSE$IGH_45; Quality: 5; mouse, Mus musculus BS R01886; MOUSE$IGH_46; Quality: 5; mouse, Mus musculus BS R01428; MOUSE$TCRB_03; Quality: 1; mouse, Mus musculus BS R02225; OCT1$CONS; Quality: 6 BS R01933; RAT$TH2B_03; Quality: 5; rat, Rattus rattus XX DR EMBL: X68362; MMOCT1A(r). DR EMBL: X70325; MMOCT1AA(r). DR EMBL: X56230; MMOCT1R(r). DR SwissProt: P25425; OCT1_MOUSE. DR PIR: S22645; S22645. DR PIR: S26569; S26569. DR Compel: C00043 DR Compel: C00049 XX RN [1] RA Rosales R., Vigneron M., Macchi M., Davidson I., Xiao J. H., Chambon P. RT In vitro binding of cell-specific and ubiquitous nuclear RT proteins to the octamer motif of the SV40 enhancer RT and related motifs present in other promoters and enhancers RL EMBO J. 6:3015-3025 (1987). RN [2] RA Kutoh E., Stroemstedt P.-E., Poellinger L. RT Functional interference between the ubiquitous and RT constitutive octamer transcription factor 1 (OTF-1) RT and the glucocorticoid receptor by direct protein-protein RT interaction involving the homeo subdomain of OTF-1 RL Mol. Cell. Biol. 12:4960-4969 (1992). RN [3] RA Nelms K., Van Ness B. RT Identification of an Octamer-Binding Site in the Human RT Kappa Light-Chain Enhancer RL Mol. Cell. Biol. 10:3843-3846 (1990). RN [4] RA Schoeler H. R., Dressler G. R., Balling R., Rohdewohld H., Gruss P. RT Oct-4: a germline-specific transcription factor mapping RT to the mouse t-complex RL EMBO J. 9:2185-2195 (1990). RN [5] RA Hermanson G. G., Briskin M., Sigman D., Wall R. RT Immunoglobulin enhancer and promoter motifs 5' of RT the B29 B-cell-specific gene RL Proc. Natl. Acad. Sci. USA 86:7341-7345 (1989). RN [6] RA Stepchenko A. G. RT The nucleotide sequence of mouse OCT-1 cDNA RL Nucleic Acids Res. 20:1419 (1992). RN [7] RA Herr W., Cleary M. A. RT The POU domain: versatility in tanscriptional regulation RT by a flexible two-in-one DNA-binding domain RL Genes Dev. 9:1679-1693 (1995). RN [8] RA Suzuki N., Peter W., Ciesiolka T., Gruss P., Schoeler H. R. RT Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2 RL Nucleic Acids Res. 21:245-252 (1993). RN [9] RA Goldsborough A., Ashworth A., Willison K. R. RT Cloning and sequencing of POU-boxes expressed in mouse testis RL Nucleic Acids Res. 18:1634-1634 (1990). RN [10] RA Cleary M. A., Stern S., Tanaka M., Herr W. RT Differential positive control by Oct-1 and Oct-2: RT activation of a transcriptionally silent motif through RT Oct-1 and VP16 corecruitment RL Genes Dev. 7:72-83 (1993). RN [11] RA Schoeler H. R., Hatzopoulos A. K., Ballingg R., Suzuki N., Gruss P. RT A family of octamer-specific proteins present during RT mouse embryogenesis: evidence for germline-specific RT expression of an Oct factor RL EMBO J. 8:2543-2550 (1989). RN [12] RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P. RT Octamer binding proteins confer transcriptional activity RT in early mouse embryogenesis RL EMBO J. 8:2551-2557 (1989). RN [13] RA Takimoto M., Quinn J. P., Farina A. R., Staudt L. M., Levens D. RT fos/jun and Octamer-binding Protein Interact with RT a Common Site in a Negative Element of the Human c-myc Gene RL J. Biol. Chem. 264:8982-8999 (1989). RN [14] RA Staudt L. M., Singh H., Sen R., Wirth T., Sharp P. A., Baltimore D. RT A lymphoid-specific protein binding to the octamer RT motif of immunoglobulin genes RL Nature 323:640-643 (1986). RN [15] RA Hanke J. H., Landolfi N. F., Tucker P. W., Capra J. D. RT Identification of murine nuclear proteins that bind RT to the conserved octamer sequence of the immunoglobulin promoter region RL Proc. Natl. Acad. Sci. USA 85:3560-3564 (1988). RN [16] RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). XX // AC T00645 XX ID T00645 XX DT 15.10.92 (created); ewi. DT 31.03.94 (updated); hwi. XX FA Oct-10 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; . XX CP brain; 12d embryo XX BS R01884; MOUSE$IGH_44; Quality: 6; mouse, Mus musculus XX RN [1] RA Schoeler H. R., Hatzopoulos A. K., Ballingg R., Suzuki N., Gruss P. RT A family of octamer-specific proteins present during RT mouse embryogenesis: evidence for germline-specific RT expression of an Oct factor RL EMBO J. 8:2543-2550 (1989). XX // AC T00646 XX ID T00646 XX DT 15.10.92 (created); ewi. DT 06.08.96 (updated); ewi. XX FA Oct-2.1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; 3.1.2.2.2.1. XX SZ 463 AA; 49.5 kDa (cDNA) XX SQ MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS SQ TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL SQ QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEE SQ PSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK SQ LKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSF SQ LANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPH SQ MVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVT SQ PPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP XX SC translated from EMBL #X13810 XX FT 173 188 acidic region (7/16) FT 180 253 POU-specific domain FT 281 340 POU homeo domain FT 374 399 serine-/threonine-rich region (14/26) FT 401 408 glycine-rich region (8/8) FT 411 424 proline-rich region (7/14) FT 426 450 serine-/threonine-rich region (10/25) FT 448 463 proline-rich region (5/16) FT 81 167 glutamine-rich region (22/87) XX IN T00643; Oct-1; rat, Rattus norvegicus. XX MX M00210; V$OCT_C XX BS R03333; AS$OCT_01; Quality: 6 BS R03334; AS$OCT_02; Quality: 6 BS R03335; AS$OCT_03; Quality: 6 BS R00413; DROME$EN_03; Quality: 6; fruit fly, Drosophila melanogaster BS R00414; DROME$EN_04; Quality: 6; fruit fly, Drosophila melanogaster BS R02571; HS$CMYC_10; Quality: 6; human, Homo sapiens BS R00663; HS$H2B_02; Quality: 6; human, Homo sapiens BS R00932; HS$IL2_03; Quality: 2; human, Homo sapiens BS R00936; HS$IL2_07; Quality: 6; human, Homo sapiens BS R00810; HSV1$IE1_01; Quality: 6; HSV-1, herpes simplex virus type 1 BS R01734; MOUSE$B29_01; Quality: 6; mouse, Mus musculus BS R00839; MOUSE$IGH_05; Quality: 6; mouse, Mus musculus BS R01682; MOUSE$IGH_40; Quality: 6; mouse, Mus musculus BS R01834; MOUSE$IGH_43; Quality: 6; mouse, Mus musculus BS R00894; MOUSE$IGKL_18; Quality: 4; mouse, Mus musculus BS R01778; MOUSE$IGKL_20; Quality: 6; mouse, Mus musculus BS R01779; MOUSE$IGKL_21; Quality: 6; mouse, Mus musculus BS R01780; MOUSE$IGKL_22; Quality: 6; mouse, Mus musculus BS R02226; OCT2$CONS; Quality: 6 XX DR EMBL: X13810; HSOTF2B(r). XX RN [1] RA Scheidereit C., Cromlish J. A., Gerster T., Kawakami RA K., Balmaceda C.-G., Currie R. A., Roeder R. G. RT A human lymphoid-specific transcription factor that RT activates immunoglobulin genes is a homeobox protein RL Nature 336:551-557 (1988). XX // AC T00647 XX ID T00647 XX DT 15.10.92 (created); ewi. DT 18.02.97 (updated); ewi. XX FA Oct-2 XX SY IgNF-A; NF-A; NF-A2; NF-III; OTF-2; OTF-2A; Oct-2A; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; 3.1.2.2.2. XX SZ 479 AA; 51.1 kDa (cDNA), 58.5, 61, 62 kDa (SDS) [42]; XX SQ MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS SQ TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL SQ QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLS SQ HPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT SQ ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK SQ RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA SQ APMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG SQ GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP XX SC SwissProt #P09086, supplemented by an additional N-terminal Met according to [39ae, II-18] XX FT 196 269 POU-specific domain FT 297 356 POU homeo domain FT 2 99 repressing domain [16]; FT 81 167 glutamine-rich region (22/87) FT 102 116 trans-activating domain I (Q domain) [33]; FT 104 111 glutamine cluster I FT 121 135 glutamine cluster II FT 146 152 glutamine cluster III FT 168 183 missing in Oct-2 of [28]; FT 189 204 acidic region (7/16) FT 390 415 serine-/threonine-rich region (14/26) FT 417 424 glycine-rich region (8/8) FT 427 440 proline-rich region (7/14) FT 442 466 serine-/threonine-rich region (10/25) FT 462 479 trans-activating domain II (P domain) [33]; FT 464 479 proline-rich region (5/16) FT 468 479 missing in Oct-2 of [47]; XX SF two Oct-2 sequences differring in the 16 AA stretch SF at 168-183 may represent splice variants [28], [40]; SF bipartite DNA-binding domain with POUs and POUh domain [27], [20]; SF three Oct-2A-related peptides in B cells [42]; SF interacting with octamer (high-affinity) and with SF heptamer (low-affinity) elements [37], [32], [25], SF the latter with 1000-fold lower affinity [25]; SF within the IgH enhancer, both elements adjacent to SF each other cooperatively bind two Oct-2 molecules [25]; SF even higher affinity of one Oct-2 molecule for the SF composite motif ATGCTAATGARAT [7]; SF however, Oct-2 does not interact with viral VP16 unless SF Ala-317 is replaced by Glu as in Oct-1 [11], [12]; SF DNA-binding specificity indistinguishable from that of Oct-1 [42]; SF POUs induces bending of the bound octamer DNA [1]; SF whole POU domain interacts with the C-terminal core domain of TBP [13]; SF 2 synergizing trans-activating domains [33], [41], [14], [16]; SF the first two modularly acting Gln-clusters within SF the N-terminal activation domain are particularly important [41], [21]; SF for full effect, C-terminal extensions of this domain SF are required [33], [41]; SF it possibly depends on additional factors [16], [14] SF and is reported to activate exclusively from proximal binding sites [10]; SF activation domain II depends on an additional B-cell SF specific activity [18], [16] such as Bob1/OBF-I [15], SF [22], [23] which interacts with the POU domain [15]; XX CP lymphoid cells XX FF activator [36], actively supporting assembly of basal FF transcription complex [19]; FF has to be present for many rounds of transcription [19]; FF expressed in CD4+, but not in CD8+ T cells; FF enhanced by ionomycin, ionomycin + PMA, or antigen [2]; FF down-regulated by IFN-alpha or TPA [8]; FF extinguished in B cell x fibroblast cell hybrids, FF leading to extinction of Ig gene expression as well [43], [46]; XX IN T00643; Oct-1; rat, Rattus norvegicus. IN T00794; TBP; human, Homo sapiens. XX MX M00210; V$OCT_C XX BS R01176; AD$ORI_02; Quality: 6; adenovirus type 4 BS R00557; HS$GG_11; Quality: 6; human, Homo sapiens BS R00663; HS$H2B_02; Quality: 6; human, Homo sapiens BS R01636; HS$IGKL_04; Quality: 6; human, Homo sapiens BS R01637; HS$IGKL_05; Quality: 6; human, Homo sapiens BS R04234; HS$LYN_01; Quality: 4; human, Homo sapiens BS R00841; MOUSE$IGH_07; Quality: 6; mouse, Mus musculus BS R00842; MOUSE$IGH_08; Quality: 6; mouse, Mus musculus BS R00861; MOUSE$IGH_27; Quality: 6; mouse, Mus musculus BS R00870; MOUSE$IGH_36; Quality: 6; mouse, Mus musculus BS R00892; MOUSE$IGKL_16; Quality: 6; mouse, Mus musculus BS R00894; MOUSE$IGKL_18; Quality: 3; mouse, Mus musculus BS R02953; MOUSE$IL2_05; Quality: 5; mouse, Mus musculus BS R02226; OCT2$CONS; Quality: 6 XX DR EMBL: X81030; HSOCT2(g). DR EMBL: M36653; HSOCT201(r). DR EMBL: X13809; HSOTF2A(r). DR EMBL: M36542; HSTFLS(r). DR SwissProt: P09086; OCT2_HUMAN. DR PIR: A31213; A31213. DR PIR: A31753; A31753. DR PIR: S06452; S06452. DR PDB: 1hdp; OCT-2 POU HOMEODOMAIN (NMR, AVERAGE STRUCTURE) HUMAN. XX RN [1] RA Verrijzer C. P., van Oosterhout J. A. W. M., van Weperen RA W. W., van der Vliet P. C. RT POU proteins bend DNA via the POU-specific domain RL EMBO J. 10:3007-3014 (1991). RN [2] RA Kang S.-M., Tsang W., Doll S., Scherle P., Ko H.-S., RA Tran A.-C., Lenardo M. J., Staudt L. M. RT Induction of the POU domain transcription factor Oct-2 RT during T-cell activation by cognate antigen RL Mol. Cell. Biol. 12:3149-3154 (1992). RN [3] RA Nelms K., Van Ness B. RT Identification of an Octamer-Binding Site in the Human RT Kappa Light-Chain Enhancer RL Mol. Cell. Biol. 10:3843-3846 (1990). RN [4] RA Yoza B. K., Roeder R. G. RT Identification of a novel factor that interacts with RT an immunoglobulin heavy-chain promoter and stimulates RT transcription in conjunction with the lymphoid cell-specific factor OTF2 RL Mol. Cell. Biol. 10:2145-2153 (1990). RN [5] RA Hermanson G. G., Briskin M., Sigman D., Wall R. RT Immunoglobulin enhancer and promoter motifs 5' of RT the B29 B-cell-specific gene RL Proc. Natl. Acad. Sci. USA 86:7341-7345 (1989). RN [6] RA Tanaka M., Herr W. RT Differential transcriptional activation by Oct-1 and RT Oct-2: interdependent activation domains induce Oct-2 phosphorylation RL Cell 60:375-386 (1990). RN [7] RA Dent C. L., Latchman D. S. RT The overlapping octamer/TAATGARAT motif is a high-affinity RT binding site for the cellular transcription factors Oct-1 and Oct-2 RL Biochem. J. 277:541-545 (1991). RN [8] RA Dent C. L., Lillycrop K. A., Bybee A., Latchman D. S., Thomas N. S. B. RT Interferon-a treatment of Daudi cells down-regulates RT the octamer binding transcription/DNA replication factors Oct-1 and Oct-2 RL J. Biol. Chem. 266:20888-20892 (1991). RN [9] RA Tanaka M., Lai J.-S., Herr W. RT Promoter-selective activation domains in Oct-1 and RT Oct-2 direct differential activation of an snRNA and mRNA promoter RL Cell 68:755-767 (1992). RN [10] RA Seipel K., Georgiev O., Schaffner W. RT Different activation domains stimulte transcription RT from remote ('enhancer') and proximal ('promoter') positions RL EMBO J. 11:4961-4968 (1992). RN [11] RA Lai J.-S., Cleary M. A., Herr W. RT A single amino acid exchange transfers VP16-induced RT positive control from the Oct-1 to the Oct-2 homeo domain RL Genes Dev. 6:2058-2065 (1992). RN [12] RA Pomerantz T. M., L Kristie J., Sharp P. A. RT Recognition of the surface of a homeo domain protein RL Genes Dev. 6:2047-2057 (1990). RN [13] RA Zwilling S., Annweiler A., Wirth T. RT The POU domains of the Oct1 and Oct2 transcription RT factors mediate specific interaction with TBP RL Nucleic Acids Res. 22:1655-1662 (1994). RN [14] RA Tanaka M., Clouston W. M., Herr W. RT The Oct-2 glutamine-rich and proline-rich activation RT domains can synergize with each other or duplicates RT of themselves to activate transcription RL Mol. Cell. Biol. 14:6046-6055 (1994). RN [15] RA Gstaiger M., Knoepfel L., Georgiev O., Schaffner W., Hovens C. M. RT A B-cell coactivator of octamer-binding transcription factors RL Nature 373:360-362 (1995). RN [16] RA Friedl E. M., Matthias P. RT Transcriptional activation and repression, two properties RT of the lymphoid-specific transcription factor Oct-2a RL Eur. J. Biochem. 234:308-316 (1995). RN [17] RA Pierani A., Heguy A., Fujii H., Roeder R. G. RT Activation of octamer-containing promoters by either RT octamer-binding transcription factor 1 (OTF-1) or RT OTF-2 and requirement of an additional B-cell-specific RT component for optimal transcription of immunoglobulin promoters RL Mol. Cell. Biol. 10:6204-6215 (1990). RN [18] RA Annweiler A., MĘller-ImmerglĘck M., Wirth T. RT Oct2 transactivation from a remote enhancer position RT requires a B-cell-restricted activity RL Mol. Cell. Biol. 12:3107-3116 (1992). RN [19] RA Arnosti D. N., Merino A., Reinberg D., Schaffner W. RT Oct-2 facilitates functional preinitiation complex RT assembly and is continuously required at the promoter RT for multiple rounds of transcription RL EMBO J. 12:157-166 (1993). RN [20] RA Jancso A., Botfield M. C., Sowers L. C., Weiss M. A. RT An altered-specificity mutation in a human POU domain RT demonstrates functional analogy between the POU-specific RT subdomain and phage l repressor RL Proc. Natl. Acad. Sci. USA 91:3887-3891 (1994). RN [21] RA Tanaka M., Herr W. RT Reconstitution of transcriptional activation domains RT by reiteration of short peptide segments reveals the RT modular organization of a glutamine-rich activation domain RL Mol. Cell. Biol. 14:6056-6067 (1994). RN [22] RA Luo Y., Fujii H., Gerster T., Roeder R. G. RT A novel B cell-derived coactivator potentiates the RT activation of immunoglogulin promoters by octamer-binding transcription RL Cell 71:231-241 (1992). RN [23] RA Strubin M., Newell J. W., Matthias P. RT OBF-1, a novel B cell-specific coactivator that stimulates RT immunoglobulin promoter activity through association RT with octamer-binding proteins RL Cell 80:497-506 (1995). RN [24] RA Currie R. A., Roeder R. G. RT Identification of an Octamer-Binding Site in the Mouse RT Kappa Light-Chain Immunoglobulin Enhancer RL Mol. Cell. Biol. 9:4239-4247 (1989). RN [25] RA LeBowitz J. H., Clerc R. G., Brenowitz M., Sharp P. A. RT The Oct-2 protein binds cooperatively to adjacent octamer sites RL Genes Dev. 3:1625-1638 (1989). RN [26] RA Lloyd J. A., Lee R. F., Lingrel L. B. RT Mutations in two regions upstream of the Agamma globin RT gene canonical promoter affect gene expression RL Nucleic Acids Res. 17:4339-4352 (1989). RN [27] RA Ko H.-S., Fast P., McBride W., Staudt L. M. RT A Human Protein Specific for the Immunoglobulin Octamer RT DNA Motif Contains a Functional Homeobox Domain RL Cell 55:135-144 (1988). RN [28] RA Scheidereit C., Cromlish J. A., Gerster T., Kawakami RA K., Balmaceda C.-G., Currie R. A., Roeder R. G. RT A human lymphoid-specific transcription factor that RT activates immunoglobulin genes is a homeobox protein RL Nature 336:551-557 (1988). RN [29] RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P. RT Octamer binding proteins confer transcriptional activity RT in early mouse embryogenesis RL EMBO J. 8:2551-2557 (1989). RN [30] RA Shibuya H., Taniguchi T. RT Identification of multiple cis-elements and trans-acting RT factors involved in the induced expression of human IL-2 gene RL Nucleic Acids Res. 17:9173-9184 (1989). RN [31] RA Sive H. L., Roeder R. G. RT Interaction of a common factor with conserved promoter RT and enhancer sequences in histone H2B, immunoglobulin, RT and U2 small nuclear RNA (snRNA) genes RL Proc. Natl. Acad. Sci. USA 83:6382-6386 (1986). RN [32] RA Kemler I., Schreiber E., Mueller M. M., Matthias P., Schaffner W. RT Octamer transcription factors bind to two different RT sequence motifs of the heavy chain promoter RL EMBO J. 8:2001-2008 (1989). RN [33] RA Gerster T., Balmaceda C.-G., Roeder R. G. RT The cell type-specific octamer transcription factor RT OTF-2 has two domains required for the activation of transcription RL EMBO J. 9:1635-1643 (1990). RN [34] RA Gerster T., Roeder R. G. RT A herpesvirus trans-activating protein interacts with RT transcription factor OTF-1 and other cellular proteins RL Proc. Natl. Acad. Sci. USA 85:6347-6351 (1988). RN [35] RA Staudt L. M., Singh H., Sen R., Wirth T., Sharp P. A., Baltimore D. RT A lymphoid-specific protein binding to the octamer RT motif of immunoglobulin genes RL Nature 323:640-643 (1986). RN [36] RA LeBowitz J. H., Kobayashi T., Staudt L., Baltimore D., Sharp P. A. RT Octamer-binding proteins from B or HeLa cells stimulate RT transcription of the immunoglobulin heavy-chain promoter in vitro RL Genes Dev. 2:1227-1237 (1988). RN [37] RA Poellinger L., Roeder R. G. RT Octamer transcription factors 1 and 2 each bind to RT two different functional elements in the immunoglobulin heavy-chain promoter RL Mol. Cell. Biol. 9:747-756 (1989). RN [38] RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). RN [39] RA Schreiber E., Matthias P., Mueller M. M., Schaffner W. RT Identification of a novel lymphoid specific octamer RT binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA) RL EMBO J. 7:4221-4229 (1988). RN [40] RA Mueller M. M., Ruppert S., Schaffner W., Matthias P. RT A cloned octamer transcription factor stimulates transcription RT from lymphoid-specific promoters in non-B cells RL Nature 336:544-551 (1988). RN [41] RA Mueller-Immerglueck M. M., Schaffner W., Matthias P. RT Transcription factor Oct-2A contains functionally RT redundant activating domains and works selectively RT from a promoter but not from a remote enhancer position RT in non-lymphoid (HeLa) cells RL EMBO J. 9:1625-1634 (1990). RN [42] RA Scheidereit C., Heguy A., Roeder R. G. RT Identification and Purification of a Human Lymphoid-Specific RT Octamer-Binding Protein (OTF-2) That Activates Transcription RT of an Immunoglobulin Promoter In Vitro RL Cell 51:783-793 (1987). RN [43] RA Bergmann Y., Strich B., Sharir H., Ber R., Laskov R. RT Extinction of Ig genes expression in myeloma x fibroblast RT somatic cell hybrids is accompanied by repression RT of the oct-2 gene encoding a B-cell specific transcription factor RL EMBO J. 9:849-855 (1990). RN [44] RA Staudt L. M., Clerc R. G., Singh H., LeBowitz J. H., RA Sharp P. A., Baltimore D. RT Cloning of a lymphoid-specific cDNA encoding a protein RT binding the regulatory octamer DNA motif RL Science 241:577-580 (1988). RN [45] RA Mocikat R., Pruijn G. J. M., van der Vliet P. C., Zachau H. G. RT An ACCC-containing protein-binding sequence in the RT neighbourhood of the decanucleotide recognition site RT of the immunoglobulin gene promoter RL Nucleic Acids Res. 16:3693 (1988). RN [46] RA Junker S., Pedersen S., Schreiber E., Matthias P. RT Extinction of an immunoglobulin promoter in cell hybrids RT is mediated by the octamer motif and correlates with RT suppression of Oct-2 expression RL Cell 61:467-474 (1990). RN [47] RA Clerc R. G., Corcoran L. M., LeBowitz J. H., Baltimore D., Sharp. P. A. RT The B-cell-specific Oct-2 protein contains POU box- RT and homeo box-type domains RL Genes Dev. 2:1570-1581 (1988). RN [48] RA Kamps M. P., Corcoran L., LeBowitz J. H., Baltimore D. RT The promoter of the human interleukin-2 gene contains RT two octamer-binding sites and is partially activated RT by the expression of Oct-2 RL Mol. Cell. Biol. 10:5464-5472 (1990). XX // AC T00648 XX ID T00648 XX DT 15.10.92 (created); ewi. DT 06.08.96 (updated); ewi. XX FA Oct-2 XX SY IgNF-A; NF-A; NF-A2; NF-III; OTF-2; OTF-2A; Oct-2.2; Oct-2A; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.2.2.2. XX SZ 479 AA; 51.3 kDa (cDNA), 60 kDa (SDS) XX SQ MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSPTGPS SQ TKIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL SQ QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAMTRPTLPDPHLS SQ HPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT SQ ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK SQ RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA SQ APMLPSPGKPTSYSPHLVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG SQ GGGGRALPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSAGPGLWWNPAPYQP XX SC translated from EMBL #X57937 XX FT 81 167 glutamine-rich region (22/87) FT 189 204 acidic region (7/16) FT 196 269 POU-specific domain FT 297 356 POU homeo domain FT 390 415 serine-/threonine-rich region (14/26) FT 417 424 glycine-rich region (8/8) FT 428 440 proline-rich region (6/13) FT 442 465 serine-/threonine-rich region (9/24) FT 464 479 proline-rich region (5/16) FT 168 183 missing in Oct-2.1, Oct-2.3, Oct-2.4, FT Oct-2B/Oct-2.5, Oct-2.6 FT 468 479 replaced by 452-583 in Oct-2B/Oct-2.5 FT 63 101 missing in Oct-2.6 FT 400 479 replaced by 384-400 in Oct-2.4 XX SF at least six splice variants known: Oct-2.1, Oct-2/Oct-2A/Oct-2.2, SF Oct-2.3, Oct-2.4, Oct-2B/Oct-2.5, and Oct-2.6 [4]; SF the glutamine-rich region acts as trans-activation SF domain through proximal octamer elements exclusively [2]; SF the C-terminal, proline-rich trans-activation domain SF depends on additional B-cell specific factors [2]; SF this domain varies among alternative splice products [4], [1]; XX CP B cells, induced pre-B cells; brain, kidney; sperm; 12d embryo XX FF activator [2]; XX IN T00643; Oct-1; rat, Rattus norvegicus. XX MX M00210; V$OCT_C XX BS R01176; AD$ORI_02; Quality: 6; adenovirus type 4 BS R03333; AS$OCT_01; Quality: 6 BS R03334; AS$OCT_02; Quality: 6 BS R03335; AS$OCT_03; Quality: 6 BS R00841; MOUSE$IGH_07; Quality: 6; mouse, Mus musculus BS R00870; MOUSE$IGH_36; Quality: 6; mouse, Mus musculus BS R01884; MOUSE$IGH_44; Quality: 6; mouse, Mus musculus BS R03426; MOUSE$IGKL_25; Quality: 6; mouse, Mus musculus BS R02226; OCT2$CONS; Quality: 6 XX DR EMBL: X57937; MMOCT22(r). DR EMBL: X81031; MMOCT2710(g). DR EMBL: X51961; MMOCT2HB(r). DR Compel: C00050 XX RN [1] RA Lillycrop K. A., Latchman D. S. RT Alternative splicing of the Oct-2 transcription factor RT RNA is differentially regulated in neuronal cells RT and B cells and results in protein isoforms with opposite RT effects on the activity of octamer/TAATGARAT-containing promoters RL J. Biol. Chem. 267:24960-24965 (1992). RN [2] RA Annweiler A., Zwilling S., Wirth T. RT Functional differences between the Oct2 transactivation RT domains determine the transactivation potential of individual Oct2 isoforms RL Nucleic Acids Res. 22:4250-4258 (1992). RN [3] RA Schoeler H. R., Hatzopoulos A. K., Ballingg R., Suzuki N., Gruss P. RT A family of octamer-specific proteins present during RT mouse embryogenesis: evidence for germline-specific RT expression of an Oct factor RL EMBO J. 8:2543-2550 (1989). RN [4] RA Wirth T., Priess A., Annweiler A., Zwilling S., Oeler B. RT Multiple Oct2 isoforms are generated by alternative splicing RL Nucleic Acids Res. 19:43-51 (1991). RN [5] RA Miller C. L., Feldhaus A. L., Rooney J. W., Rhodes RA L. D., Sibley C. H., Singh H. RT Regulation and a possible stage-specific function RT of Oct-2 during pre-B-cell differentiation RL Mol. Cell. Biol. 11:4885-4894 (1991). XX // AC T00649 XX ID T00649 XX DT 27.01.93 (created); hse. XX FA Oct-2 XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX SZ A: 60 kDa (SDS); B: 75 kDa (SDS) XX CP lymphoid cells, intestine, testis, kidney, nervous system XX IN T00641; Oct-1; human, Homo sapiens. IN T00642; Oct-1; clawed frog, Xenopus laevis. IN T00643; Oct-1; rat, Rattus norvegicus. IN T00644; Oct-1A; mouse, Mus musculus. IN T00959; Oct-1; monkey, Cercopithecus aethiops. IN T01031; Oct-1; chick, Gallus gallus. IN T01157; Oct-1; gibbon ape, Hylobates lar. XX MX M00210; V$OCT_C XX BS R02226; OCT2$CONS; Quality: 6 XX RN [1] RA Poellinger L., Roeder R. G. RT Octamer transcription factors 1 and 2 each bind to RT two different functional elements in the immunoglobulin heavy-chain promoter RL Mol. Cell. Biol. 9:747-756 (1989). RN [2] RA Schreiber E., Matthias P., Mueller M. M., Schaffner W. RT Identification of a novel lymphoid specific octamer RT binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA) RL EMBO J. 7:4221-4229 (1988). RN [3] RA Kamps M. P., Corcoran L., LeBowitz J. H., Baltimore D. RT The promoter of the human interleukin-2 gene contains RT two octamer-binding sites and is partially activated RT by the expression of Oct-2 RL Mol. Cell. Biol. 10:5464-5472 (1990). RN [4] RA Wirth T., Priess A., Annweiler A., Zwilling S., Oeler B. RT Multiple Oct2 isoforms are generated by alternative splicing RL Nucleic Acids Res. 19:43-51 (1991). RN [5] RA Miller C. L., Feldhaus A. L., Rooney J. W., Rhodes RA L. D., Sibley C. H., Singh H. RT Regulation and a possible stage-specific function RT of Oct-2 during pre-B-cell differentiation RL Mol. Cell. Biol. 11:4885-4894 (1991). XX // AC T00650 XX ID T00650 XX DT 27.01.93 (created); hse. DT 06.08.96 (updated); ewi. XX FA Oct-2 XX SY Oct-2.2; Oct-2A; XX OS rat, Rattus rattus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.2.2.2. XX SZ 479 AA; 51.2 kDa (cDNA), 60 kDa (SDS) XX SQ MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSPTGPS SQ TKIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL SQ QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAMTRPTLPDPHLS SQ HPQPSKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT SQ ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK SQ RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA SQ APMLPSPGKPTSYSPHLVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG SQ GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLTGLNPSAGPGLWWNPAPYQP XX SC translated from EMBL #L25864 XX FT 81 167 glutamine-rich region (22/87) FT 189 204 acidic region (7/16) FT 196 269 POU-specific domain FT 297 356 POU homeo domain FT 390 415 serine-/threonine-rich region (14/26) FT 417 424 glycine-rich region (8/8) FT 427 440 proline-rich region (7/14) FT 442 465 serine-/threonine-rich region (9/24) FT 464 479 proline-rich region (5/16) XX SF the four known splice variants (Oct-2.1, Oct-2/Oct2A/Oct-2.2, SF Oct-2.7, and Oct-2.8) differ in their DNA-binding specificity [3]; XX CP lymphoid cells, intestine, testis, kidney, nervous CP system, here in suprachiasmatic and medial mammillary CP nuclei of hypothalamus, granule and red nucleus (adults), CP widespread expression in emrbyonal nervous system [1]; CN embryonal telencephalon [1]; XX FF up-regulated by nerve growth factor (NGF) [2]; XX IN T00641; Oct-1; human, Homo sapiens. IN T00642; Oct-1; clawed frog, Xenopus laevis. IN T00643; Oct-1; rat, Rattus norvegicus. IN T00644; Oct-1A; mouse, Mus musculus. IN T00959; Oct-1; monkey, Cercopithecus aethiops. IN T01031; Oct-1; chick, Gallus gallus. IN T01157; Oct-1; gibbon ape, Hylobates lar. XX MX M00210; V$OCT_C XX BS R02226; OCT2$CONS; Quality: 6 XX DR EMBL: L25864; RRASOB(r). XX RN [1] RA He X., Treacy M. N., Simmons D. M., Ingraham H. A., RA Swanson L. W., Rosenfeld M. G. RT Expression of a large family of POU-domain regulatory RT genes in mammalian brain development RL Nature 340:35-42 (1989). RN [2] RA Wood J. N., Lillycrop K. A., Dent C. L., Ninkina N. RA N., Beech M. M., Willoughby J. J., Winter J., Latchman D. S. RT Regulation of expression of the neuronal POU Protein RT Oct-2 by nerve growth factor RL J. Biol. Chem. 267:17787-17791 (1992). RN [3] RA Lillycrop K. A., Latchman D. S. RT Alternative splicing of the Oct-2 transcription factor RT RNA is differentially regulated in neuronal cells RT and B cells and results in protein isoforms with opposite RT effects on the activity of octamer/TAATGARAT-containing promoters RL J. Biol. Chem. 267:24960-24965 (1992). XX // AC T00651 XX ID T00651 XX DT 15.10.92 (created); ewi. DT 08.08.96 (updated); ewi. XX FA Oct-4 XX SY NF-A3; Oct-3; Oct-3A; Oct-4A; Oct-5; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.2.5.1.2. XX SZ 352 AA; 38 kDa (cDNA), 42, 35 kDa (SDS) XX SQ MAGHLASDFAFSPPPGGGDGSAGLEPGWVDPRTWLSFQGPPGGPGIGPGSEVLGISPCPP SQ AYEFCGGMAYCGPQVGLGLVPQVGVETLQPEGQAGARVESNSEGTSSEPCADRPNAVKLE SQ KVEPTPEESQDMKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRF SQ EALQLSLKNMCKLRPLLEKWVEEADNNENLQEICKSETLVQARKRKRTSIENRVRWSLET SQ MFLKCPKPSLQQITHIANQLGLEKDVVRVWFCNRRQKGKRSSIEYSQREEYEATGTPFPG SQ GAVSFPLPPGPHFGTPGYGSPHFTTLYSVPFPEGEAFPSVPVTALGSPMHSN XX SC SwissProt #P20263 XX FT 13 81 proline-rich region (14/69) FT 297 348 proline-rich region (13/52) FT 1 67 missing in Oct-5 FT 127 282 DNA-binding domain FT 123 185 POU-specific domain FT 223 282 POU homeo domain XX SF exists in a najor (42 kDa) and a minor form (35 kDa) SF usage of a downstream translation initiation codon SF gives rise to Oct-5 [18], [19], [2], [20]; SF both POUs and POUh domain are required for efficient DNA-binding [1]; SF teh N-terminal proline-rich region acts as a trans-activating domain [3]; XX CP day 7.5, 8.5 embryos, brain (12d embryos); PGC, undifferentiated CP embryonal cells [2], [18]; XX FF activator in early mouse development [19], [2], [3]; FF requires an additional factor, present in embryonal FF stem cells, to activate from remote enhancer elements [12]; FF may induce differentiation and is down-regulated during FF differentiation [3], [7]; FF also down-regulated by differentiation-inducing retinoic FF acid [3], [10], accompanied by enhanced methylation FF and altered chromatin structure of the oct4 gene [6]; FF synergistically cooperates with Sox-2 [5]; XX BS R02824; MOUSE$CABL1_01; Quality: 6; mouse, Mus musculus BS R00303; MOUSE$E1_01; Quality: 6; mouse, Mus musculus BS R00304; MOUSE$E1_02; Quality: 6; mouse, Mus musculus BS R00305; MOUSE$E1_03; Quality: 6; mouse, Mus musculus BS R00306; MOUSE$E1_04; Quality: 6; mouse, Mus musculus BS R00864; MOUSE$IGH_30; Quality: 6; mouse, Mus musculus BS R01884; MOUSE$IGH_44; Quality: 6; mouse, Mus musculus BS R01885; MOUSE$IGH_45; Quality: 6; mouse, Mus musculus BS R01886; MOUSE$IGH_46; Quality: 6; mouse, Mus musculus BS R02227; OCT4$CONS; Quality: 6 XX DR EMBL: M34381; MMOCT301(r). DR EMBL: X52437; MMOCT4P(r). DR SwissProt: P20263; OCT3_MOUSE. DR PIR: A34206; A34206. DR PIR: A34672; A34672. DR PIR: S10924; S10924. DR PDB: 1ocp; SOLUTION STRUCTURE OF OCT3 POU-HOMEODOMAIN MUS MUSCULUS. XX RN [1] RA Imagawa M., Miyamoto A., Shirakawa M., Hamada H., Muramatsu M. RT Stringent integrity requirements for both trans-activation RT and DNA-binding in a trans-activator, Oct3 RL Nucleic Acids Res. 19:4503-4508 (1991). RN [2] RA Schoeler H. R., Dressler G. R., Balling R., Rohdewohld H., Gruss P. RT Oct-4: a germline-specific transcription factor mapping RT to the mouse t-complex RL EMBO J. 9:2185-2195 (1990). RN [3] RA Okamoto K., Okazawa H., Okuda A., Sakai M., Muramatsu M., Hamada H. RT A novel octamer binding transcription factor is differentially RT expressed in mouse embryonic cells RL Cell 60:461-472 (1990). RN [4] RA Treacy M. N., He X., Rosenfeld M. G. RT I-POU: a POU-domain protein that inhibits neuron-specific gene activation RL Nature 350:577-584 (1991). RN [5] RA Yuan H., Corbi N., Basilico C., Dailey L. RT Developmental-specific activity of the FGF-4 enhancer RT requires the synergistic action of Sox2 and Oct-3 RL Genes Dev. 9:2635-2345 (1995). RN [6] RA Ben-Shushan E., Pikarsky E., Klar A., Bergman Y. RT Extinction of Oct-3/4 gene expression in embryonal RT carcinoma X fibroblast somatic cell hybrids is accompanied RT by changes in the methylation status, chromatin structure RT and transcriptional activity of the Oct-3/4 upstream region RL Mol. Cell. Biol. 13:891-901 (1993). RN [7] RA Shimazaki T., Okazawa H., Fujii H., Ikeda M., Tamai RA K., McKay R. D. G., Muramatsu M., Hamada H. RT Hybrid cell extinction and re-expression of Oct-3 RT function correlates with differentiation potential RL EMBO J. 12:4489-4498 (1993). RN [8] RA Schoorlemmer J., van Puijenbroek A., van den Eijnden RA M., Jonk L., Pals C., Kruijer W. RT Characterization of a negative retinoic acid response RT element in the murine Oct4 promoter RL Mol. Cell. Biol. 14:1122-1136 (1994). RN [9] RA Pikarsky E., Sharir H., Cen-Shushan E., Bergman Y. RT Retinoic acid represses Oct-3/4 gene expression through RT several retinoic acid-responsive elements located RT in the promoter-enhancer region RL Mol. Cell. Biol. 14:1026-1038 (1994). RN [10] RA Rosner M. H., Vigano M. A., Ozato K., Timmons P. M., RA Poirier F., Rigby P. W. J., Staudt L. M. RT A POU-domain transcription factor in early stem cells RT and germ cells of the mammalian embryo RL Nature 345:686-692 (1990). RN [11] RA Okazawa H., Okamoto K., Ishino F., Ishino-Kaneko T., RA Takeda S., Toyoda Y., Muramatsu M., Hamada H. RT The oct3 gene, a gene for an embryonic transcription RT factor, is controlled by a retinoic acid repressible enhancer RL EMBO J. 10:2997-3005 (1991). RN [12] RA Schoeler H. R., Ciesiolka T., Gruss P. RT A nexus between Oct-4 and E1A: implications for gene RT regulation in embryonic stem cells RL Cell 66:291-304 (1991). RN [13] RA Hinkley C. S., Martin J. F., Leibham D., Perry M. RT Sequential expression of multiple PPU proteins during RT amphibian early development RL Mol. Cell. Biol. 12:638-649 (1992). RN [14] RA Ruvkun G., Finney M. RT Regulation of transcription and cell identiy by POU domain proteins RL Cell 64:475-478 (1991). RN [15] RA Rosenfeld M. G. RT POU-domain transcription factors: pou-er-ful developmental regulators RL Genes Dev. 5:897-907 (1991). RN [16] RA Siracusa L. D., Rosner M. H., Vigano M. A., Gilbert RA D. J., Staudt L. M., Copeland N. G., Jenkins N. A. RT Chromosomal location of the octamer transcription RT factors, Otf-1, Otf-2, and Otf-3, defines multiple RT Otf-3-related sequences dispersed in the mouse genome RL Genomics 10:313-326 (1991). RN [17] RA Morita E. H., Shirakawa M., Hayashi F., Imagawa M., Kyogoku Y. RT Secondary structure of the oct-3 POU homeodomain as RT determined by 1H-15N NMR spectroscopy RL FEBS Lett. 321:107-110 (1993). RN [18] RA Schoeler H. R., Hatzopoulos A. K., Ballingg R., Suzuki N., Gruss P. RT A family of octamer-specific proteins present during RT mouse embryogenesis: evidence for germline-specific RT expression of an Oct factor RL EMBO J. 8:2543-2550 (1989). RN [19] RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P. RT Octamer binding proteins confer transcriptional activity RT in early mouse embryogenesis RL EMBO J. 8:2551-2557 (1989). RN [20] RA Schoeler H. R., Ruppert S., Suzuki N., Chowdhury K., Gruss P. RT New type of POU domain in germ line-specific protein Oct-4 RL Nature 344:435-439 (1990). RN [21] RA Lenardo M.-J., Staudt L., Robbins P., Kuang A., Mulligan R. C., Baltimore D. RT Repression of the IgH enhancer in teratocarcinoma RT cells associated with a novel octamer factor RL Science 243:544-546 (1989). RN [22] RA Rosner M. H., De Santo R. J., Arnheiter A., Staudt L. M. RT Oct-3 is a maternal factor required for the first mouse embryonic division RL Cell 64:1103-1110 (1991). RN [23] RA Meijer D., Graus A., Kraay R., Langeveld A., Mulder M. P., Grosveld G. RT The octamer binding factor Oct6: cDNA cloning and RT expression in early embryonic cells RL Nucleic Acids Res. 18:7357-7365 (1990). XX // AC T00652 XX ID T00652 XX DT 27.01.93 (created); hse. DT 08.08.96 (updated); ewi. XX FA Oct-4A XX SY Oct-3; Oct-3A; Oct-4; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; 3.1.2.5.1.2. XX SZ 360 AA; 38.6 kDa (cDNA), 42, 35 kDa (SDS) XX SQ MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGI SQ PPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPG SQ AVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFS SQ QTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENR SQ VRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEA SQ AGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHSN XX SC SwissProt #Q01860 XX FT 1 135 replaced by 1-40 in Oct-4B FT 130 212 POU-specific domain FT 230 289 POU homeo domain FT 91 138 acidic region (12/48) FT 13 89 glycine-/proline-rich region (43/77) FT 304 347 proline-rich region (11/44) XX SF exists in a major (42 kDa) and a minor (35 kDa) form SF a splice variant is Oct-4B (= Oct-3B), whereas Oct-3C SF is the product of a distinct gene [2]; XX CP embryonic cells, adult heart, kidney, liver, ovary and testis [2]; XX FF activator [3]; XX BS R02227; OCT4$CONS; Quality: 6 XX DR EMBL: Z11898; HSOTF3AMR(r). DR EMBL: Z11900; HSOTF3G(g). DR SwissProt: Q01860; OC3A_HUMAN. DR PIR: S25561; S25561. XX RN [1] RA He X., Treacy M. N., Simmons D. M., Ingraham H. A., RA Swanson L. W., Rosenfeld M. G. RT Expression of a large family of POU-domain regulatory RT genes in mammalian brain development RL Nature 340:35-42 (1989). RN [2] RA Takeda J., Seino S., Bell G. I. RT Human Oct3 gene family: cDNA sequences, alternati-ve RT splicing, gene organization, chromosomal location, RT and expression at low levels in adult tissues RL Nucleic Acids Res. 20:4613-4620 (1992). RN [3] RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P. RT Octamer binding proteins confer transcriptional activity RT in early mouse embryogenesis RL EMBO J. 8:2551-2557 (1989). XX // AC T00653 XX ID T00653 XX DT 15.10.92 (created); ewi. DT 08.08.96 (updated); ewi. XX FA Oct-5 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.2.5.1.1. XX SZ 285 AA; 31.7 kDa (cDNA) XX SQ MAYCGPQVGLGLVPQVGVETLQPEGQAGARVESNSEGTSSEPCADRPNAVKLEKVEPTPE SQ ESQDMKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSL SQ KNMCKLRPLLEKWVEEADNNENLQEICKSETLVQARKRKRTSIENRVRWSLETMFLKCPK SQ PSLQQITHIANQLGLEKDVVRVWFCNRRQKGKRSSIEYSQREEYEATGTPFPGGAVSFPL SQ PPGPHFGTPGYGSPHFTTLYSVPFPEGEAFPSVPVTALGSPMHSN XX SC edited from SwissProt #P20263 according to [97b] XX FT 19 64 acidic region (11/46) FT 56 138 POU-specific domain FT 156 215 POU homeo domain FT 230 281 proline-rich domain (13/52) XX SF arises from the oct3/oct4 gene from a downstream translation SF initiation codon [3], [4], [1], [5]; XX CP (day 7.5, 8.5 embryos) XX FF activator during early mouse development [4], [1], [2]; XX BS R00864; MOUSE$IGH_30; Quality: 6; mouse, Mus musculus BS R00870; MOUSE$IGH_36; Quality: 6; mouse, Mus musculus BS R01885; MOUSE$IGH_45; Quality: 6; mouse, Mus musculus XX RN [1] RA Schoeler H. R., Dressler G. R., Balling R., Rohdewohld H., Gruss P. RT Oct-4: a germline-specific transcription factor mapping RT to the mouse t-complex RL EMBO J. 9:2185-2195 (1990). RN [2] RA Okamoto K., Okazawa H., Okuda A., Sakai M., Muramatsu M., Hamada H. RT A novel octamer binding transcription factor is differentially RT expressed in mouse embryonic cells RL Cell 60:461-472 (1990). RN [3] RA Schoeler H. R., Hatzopoulos A. K., Ballingg R., Suzuki N., Gruss P. RT A family of octamer-specific proteins present during RT mouse embryogenesis: evidence for germline-specific RT expression of an Oct factor RL EMBO J. 8:2543-2550 (1989). RN [4] RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P. RT Octamer binding proteins confer transcriptional activity RT in early mouse embryogenesis RL EMBO J. 8:2551-2557 (1989). RN [5] RA Schoeler H. R., Ruppert S., Suzuki N., Chowdhury K., Gruss P. RT New type of POU domain in germ line-specific protein Oct-4 RL Nature 344:435-439 (1990). XX // AC T00654 XX ID T00654 XX DT 15.10.92 (created); ewi. XX FA Oct-5 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP B cells XX RN [1] RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P. RT Octamer binding proteins confer transcriptional activity RT in early mouse embryogenesis RL EMBO J. 8:2551-2557 (1989). XX // AC T00655 XX ID T00655 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Oct-6 XX SY SCIP (rat); Tst-1 (rat); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; 3.1.2.3.3. XX SQ MHHEWLGAGAGHPVGLAHPQWLPTGGGGGGDWAGAHLEHGKAGGGGTGRADDGGGGGGFH SQ ARLVHQGAAHAGAAWAQGSTAHHLGPAMSPSPGASGGHQPQPLGLYAQAAYPGGGGGGLA SQ GMLAAGGGGAGPGLHHALHEDGHEAQLEPSPPPHLGAHGHAHGHAHAGGLHAAAAHLHPG SQ AGGGGSSVGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTI SQ CRFEALQLSFKNMCKLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGA SQ LESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYA SQ PGELGPGGGGASPPSAPPPPPPAALHHHHHHTLPGSVQ XX SC SwissProt #Q03052 XX CP B-cells XX MX M00133; V$TST1_01 XX BS R01176; AD$ORI_02; Quality: 6; adenovirus type 4 BS R02228; OCT6$CONS; Quality: 6 XX DR EMBL: Z18284; HSOCT6TR(r). DR SwissProt: Q03052; OCT6_HUMAN. DR PIR: S30218; S30218. XX RN [1] RA Tobler A., Schreiber E., Fontana A. RT The human Oct-6 POU transcription factor lacks the RT first 50 amino acids of its murine counterpart RL Nucleic Acids Res. 21:1043-1043 (1993). RN [2] RA Schreiber E., Harschman K., Kemler I., Malipiero U., RA Schaffner W., Fontana A. RT Astrocytes and glioblastoma cells express novel octamer-DNA RT binding proteins distinct from ubiquitous Oct-1 and RT B-cell type Oct-2 proteins RL Nucleic Acids Res. 18:5495-5503 (1990). XX // AC T00656 XX ID T00656 XX DT 15.10.92 (created); ewi. DT 08.08.96 (updated); ewi. XX FA Oct-6 XX SY SCIP (rat); Tst-1 (rat); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.2.3.3. XX SZ 449 AA; 45.3 kDa (cDNA) XX SQ MATTAQYLPRGPGGGAGGTGPLMHPDAAAAAAAAAERLHAGAAYREVQKLMHHEWLGAGA SQ GHPVGLAHPQWLPTGGGGGGDWAGGPHLEHGKAGGGGTGRADDGGGGGGFHARLVHQGAA SQ HAGAAWAQGGTAHHLGPAMSPSPGAGGGHQPQPLGLYAQAAYPGGGGGGLAGMLAAGGGG SQ AGPGLHHALHEDGHEAQLEPSPPPHLGAHGHAHGHAHAGGLHAAAAHLHPGAGGGGSSVG SQ EHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLS SQ FKNMCKLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCP SQ KPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGG SQ SASPPSAPPPPPPAALHHHHHHTLPGSVQ XX SC SwissProt #P21952 XX FT 27 43 alanine-rich region (12/17) FT 57 184 glycine-rich region (47/128) FT 186 229 histidine-rich region (13/44) FT 404 433 proline-rich region (12/39) FT 246 319 POU-specific domain FT 337 396 POU homeo domain XX SF Oct -6 of [10]; SF the His-rich region contains a stretch of His-(Gy/Ala)-repeats [10]; SF POUs domain induces DNA-bending [1]; SF the N-terminal third contains a potent Gly-/Ala-rich SF trans-activation domain with internal functional redundancy [3]; XX CP undifferentiated embryonal cells, glial precursor CP cells of CNS (O-2A cells) and PNS (Schwann cells) [10]; CN heart, kidney, liver, muscle, salivary gland, spleen, testis [2]; XX FF activator [10], [3]; FF stimulates viral replication by enhancing large T-antigen expression [4]; FF physically inetracts and synergistically cooperates FF with T-Ag in inducing viral gene transcription [6]; FF down-regulated during embryonic stem cell differentiation [10]; FF re-appearing in Schwann (glial precursor) cells immediately FF before they differentiate into myelin--forming cells [10]; FF found in the cortex, but not in the cerebellum during FF brain development [10]; XX IN T00788; T-Ag; SV40, simian virus 40. XX MX M00133; V$TST1_01 XX BS R01176; AD$ORI_02; Quality: 6; adenovirus type 4 BS R02824; MOUSE$CABL1_01; Quality: 6; mouse, Mus musculus BS R00870; MOUSE$IGH_36; Quality: 6; mouse, Mus musculus BS R01885; MOUSE$IGH_45; Quality: 6; mouse, Mus musculus BS R02228; OCT6$CONS; Quality: 6 XX DR EMBL: X56959; MDSCIP(r). DR EMBL: X54628; MMOCT6GR(r). DR EMBL: X57482; MMOCT6R(r). DR SwissProt: P21952; OCT6_MOUSE. DR PIR: S11999; S11999. DR PIR: S13083; S13083. XX RN [1] RA Verrijzer C. P., van Oosterhout J. A. W. M., van Weperen RA W. W., van der Vliet P. C. RT POU proteins bend DNA via the POU-specific domain RL EMBO J. 10:3007-3014 (1991). RN [2] RA Hara Y., Rovescalli A. C., Kim Y., Nirenberg M. RT Structure and evolution of four POU domain genes expressed in mouse brain RL Proc. Natl. Acad. Sci. USA 89:3280-3284 (1992). RN [3] RA Meijer D., Graus A., Grosveld G. RT Mapping the transactivation domain of the Ict-6 POU transcription factor RL Nucleic Acids Res. 20:2241-2247 (1992). RN [4] RA Wegner M., Drolet D. W., Rosenfeld M. G. RT Regulation of JC virus by the POU-domain transcription RT factor Tst-1: Implications for progressive multifocal leukoencephalopathy RL Proc. Natl. Acad. Sci. USA 90:4743-4747 (1993). RN [5] RA Zimmerman E. C., Jones C. M., Fet V., Hogan B. L. M., Magnuson M. A. RT Nucleotide sequence of mouse SCIP cDNA, a POU-domain transcription factor RL Nucleic Acids Res. 19:956-956 (1991). RN [6] RA Renner K., Leger H., Wegner M. RT The POU domain protein Tst-1 and papovaviral large RT tumor antigen function synergistically to stimulate RT glia-specific gene expression of JC virus RL Proc. Natl. Acad. Sci. USA 91:6433-6437 (1994). RN [7] RA Schoeler H. R., Hatzopoulos A. K., Ballingg R., Suzuki N., Gruss P. RT A family of octamer-specific proteins present during RT mouse embryogenesis: evidence for germline-specific RT expression of an Oct factor RL EMBO J. 8:2543-2550 (1989). RN [8] RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P. RT Octamer binding proteins confer transcriptional activity RT in early mouse embryogenesis RL EMBO J. 8:2551-2557 (1989). RN [9] RA Meijer D., Graus A., Kraay R., Langeveld A., Mulder M. P., Grosveld G. RT The octamer binding factor Oct6: cDNA cloning and RT expression in early embryonic cells RL Nucleic Acids Res. 18:7357-7365 (1990). RN [10] RA Suzuki N., Rohdewohld H., Neuman T., Gruss P., Schoeler H. R. RT Oct-6: a POU transcription factor expressed in embryonal RT stem cells and in the developing brain RL EMBO J. 9:3723-3732 (1990). XX // AC T00657 XX ID T00657 XX DT 15.10.92 (created); ewi. XX FA Oct-7 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; . XX CP brain; 12d embryo XX BS R01884; MOUSE$IGH_44; Quality: 6; mouse, Mus musculus XX RN [1] RA Schoeler H. R., Hatzopoulos A. K., Ballingg R., Suzuki N., Gruss P. RT A family of octamer-specific proteins present during RT mouse embryogenesis: evidence for germline-specific RT expression of an Oct factor RL EMBO J. 8:2543-2550 (1989). XX // AC T00658 XX ID T00658 XX DT 15.10.92 (created); ewi. XX FA Oct-8 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; . XX CP brain, kidney; 12d embryo XX BS R01884; MOUSE$IGH_44; Quality: 6; mouse, Mus musculus XX RN [1] RA Schoeler H. R., Hatzopoulos A. K., Ballingg R., Suzuki N., Gruss P. RT A family of octamer-specific proteins present during RT mouse embryogenesis: evidence for germline-specific RT expression of an Oct factor RL EMBO J. 8:2543-2550 (1989). XX // AC T00659 XX ID T00659 XX DT 15.10.92 (created); ewi. XX FA Oct-9 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; . XX CP brain, kidney; 12d embryo XX BS R01884; MOUSE$IGH_44; Quality: 6; mouse, Mus musculus XX RN [1] RA Schoeler H. R., Hatzopoulos A. K., Ballingg R., Suzuki N., Gruss P. RT A family of octamer-specific proteins present during RT mouse embryogenesis: evidence for germline-specific RT expression of an Oct factor RL EMBO J. 8:2543-2550 (1989). XX // AC T00660 XX ID T00660 XX DT 15.10.92 (created); ewi. XX FA Octa-factor XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01500; HS$U2SN_06; Quality: 6; human, Homo sapiens XX RN [1] RA Janson L., Bark C., Petterson U. RT Identification of proteins interacting with the enhancer RT of human U2 small nuclear RNA genes RL Nucleic Acids Res. 15:4997-5016 (1987). RN [2] RA Janson L., Weller P., Pettersson U. RT Nuclear Factor I can Functionally Replace Transcription RT Factor Sp1 in a U2 Small Nuclear RNA Gene Enhancer RL J. Mol. Biol. 205:387-396 (1989). XX // AC T00661 XX ID T00661 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA octamer-binding factor XX OS clawed frog, Xenopus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX BS R01501; XENLA$U2SN_07; Quality: 6; clawed frog, Xenopus laevis BS R01502; XENLA$U2SN_08; Quality: 6; clawed frog, Xenopus laevis XX RN [1] RA Tebb G., Mattaj I. W. RT The Xenopus laevis U2 Gene Distal Sequence Element RT (Enhancer) Is Composed of Four Subdomains That Can RT Act Independently and Are Partly Functionally Redundant RL Mol. Cell. Biol. 9:1682-1690 (1989). XX // AC T00662 XX ID T00662 XX DT 15.10.92 (created); ewi. DT 06.08.96 (updated); ewi. XX FA Oct-2B XX SY OTF-2B; Oct-2.5; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; 3.1.2.2.2.5. XX SZ 75 kDa (SDS) [3]; XX CP lymphoid cells XX MX M00210; V$OCT_C XX BS R00663; HS$H2B_02; Quality: 6; human, Homo sapiens BS R00841; MOUSE$IGH_07; Quality: 6; mouse, Mus musculus BS R00861; MOUSE$IGH_27; Quality: 6; mouse, Mus musculus BS R00894; MOUSE$IGKL_18; Quality: 6; mouse, Mus musculus BS R02226; OCT2$CONS; Quality: 6 XX DR PIR: A31213; A31213. DR PIR: A31753; A31753. DR PIR: S06452; S06452. DR PIR: S06453; S06453. XX RN [1] RA Tanaka M., Lai J.-S., Herr W. RT Promoter-selective activation domains in Oct-1 and RT Oct-2 direct differential activation of an snRNA and mRNA promoter RL Cell 68:755-767 (1992). RN [2] RA Poellinger L., Roeder R. G. RT Octamer transcription factors 1 and 2 each bind to RT two different functional elements in the immunoglobulin heavy-chain promoter RL Mol. Cell. Biol. 9:747-756 (1989). RN [3] RA Schreiber E., Matthias P., Mueller M. M., Schaffner W. RT Identification of a novel lymphoid specific octamer RT binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA) RL EMBO J. 7:4221-4229 (1988). RN [4] RA Kamps M. P., Corcoran L., LeBowitz J. H., Baltimore D. RT The promoter of the human interleukin-2 gene contains RT two octamer-binding sites and is partially activated RT by the expression of Oct-2 RL Mol. Cell. Biol. 10:5464-5472 (1990). XX // AC T00663 XX ID T00663 XX DT 15.10.92 (created); ewi. XX FA oct-B2 XX SY B2 octamer binding factor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (B cells, BJA-B, MOLT-4) XX MX M00210; V$OCT_C XX BS R01090; HS$M2DRA_05; Quality: 6; human, Homo sapiens BS R01091; HS$M2DRA_06; Quality: 6; human, Homo sapiens XX RN [1] RA Stimac E., Lyons S., Pious D. RT Transcription of HLA Class II Genes in the Absence RT of B-Cell-Specific Octamer-Binding Factor RL Mol. Cell. Biol. 8:3734-3739 (1988). RN [2] RA Rosales R., Vigneron M., Macchi M., Davidson I., Xiao J. H., Chambon P. RT In vitro binding of cell-specific and ubiquitous nuclear RT proteins to the octamer motif of the SV40 enhancer RT and related motifs present in other promoters and enhancers RL EMBO J. 6:3015-3025 (1987). XX // AC T00664 XX ID T00664 XX DT 15.10.92 (created); ewi. XX FA oct-B3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa,BJA-B,MOLT-4) XX MX M00210; V$OCT_C XX BS R01402; SV$SV40_34; Quality: 6; SV40, simian virus 40 XX RN [1] RA Rosales R., Vigneron M., Macchi M., Davidson I., Xiao J. H., Chambon P. RT In vitro binding of cell-specific and ubiquitous nuclear RT proteins to the octamer motif of the SV40 enhancer RT and related motifs present in other promoters and enhancers RL EMBO J. 6:3015-3025 (1987). XX // AC T00665 XX ID T00665 XX DT 20.11.92 (created); ewi. XX FA Oct-2C XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP B-cells XX MX M00210; V$OCT_C XX BS R00861; MOUSE$IGH_27; Quality: 6; mouse, Mus musculus BS R02226; OCT2$CONS; Quality: 6 XX RN [1] RA Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W., Fontana A. RT Astrocytes and glioblastoma cells express novel octamer-DNA RT binding proteins distinct from the ubiquitous Oct-1 RT and B cell type Oct-2 proteins RL Nucleic Acids Res. 18:5495-5503 (1990). XX // AC T00666 XX ID T00666 XX DT 27.01.93 (created); hse. XX FA Oct-R XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX FF binds to the motif only in the context of the H2B box XX BS R02229; OCTR$CONS; Quality: 6 XX RN [1] RA Smith D. P., Old R. W. RT Xenopus laevis Oct-1 does not bind to certain histone RT H2B gene promoter octamer motifs for which a novel RT octamer-binding factor has high affinity RL Nucleic Acids Res. 19:815-821 (1991). XX // AC T00667 XX ID T00667 XX DT 03.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Odd XX SY Odd-skipped; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.2.4. XX SZ 392 AA XX SQ MSSTSASPISNITVDDELNLSREQDFAEDDFIVIKEERETSLSPMLTPPHTPTEEPLRRV SQ HPAISEEAVATQLHMRHMAHYQQQQQQQQQQQQHRLWLQMQQQQQQHQAPQQYPVYPTAS SQ ADPVAVHQQLMNHWIRNAAIYQQQQQQQQHPHHHHHHGHPHHPHPHPHHVRPYPAGLHSL SQ HAAVVGRHFGAMPTLKLGGAGGASGVPSCATGSSRPKKQFICKYCNRQFTKSYNLLIHER SQ THTDERPYSCDICGKAFRRQDHLRDHRYIHSKDKPFKCSDCGKGFCQSRTLAVHKVTHLE SQ EGPHKCPICQRSFNQRANLKSHLQSHSEQSTKEVVVTTSPATSHSVPNQALSSPQPENLV SQ QHLPVLDLSSSSSSSEKPKRMLGFTIDEIMSR XX SC SwissProt #P23803 XX SF 4 zinc finger motifs SF glutamine-rich region, serine-/threonine-rich region XX FF pair-rule gene product XX DR SwissProt: P23803; ODD_DROME. DR PIR: S11998; S11998. DR Flybase: FBgn0002985; odd. XX RN [1] RA Coulter D. E., Swaykus E. A., Beran-Koehn A., Goldberg RA D., Wieschaus E., Schedl P. RT Molecular analysis of odd-skipped, a zinc finger encoding RT segmentation gene with a novel pair-rule expression pattern RL EMBO J. 8:3795-3804 (1990). XX // AC T00668 XX ID T00668 XX DT 15.10.92 (created); ewi. DT 19.02.97 (updated); hiwi. XX FA Opaque-2 XX SY O2; opaque-2; XX OS maize, Zea mays OC eukaryota; plantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX CL C0008; bZIP; 1.1.5.5.2. XX SZ 460 AA; 50.1 kDa (cDNA) XX SQ MEHVISMEEILGPFWELLPPPAPEPEPEPEPEREQPPVTGIVVGSVIDVAAAGHGDGDMM SQ DQQHATEWTFERLLEEEALTTSTPPPVVVVPNSCCSGALNADRPPVMEEAVTMAPAAVSS SQ AVVGDPMEYNAILRRKLEEDLEAFKMWRAASSVVTSDQRSQGSNNHTGGSSIRNNPVQNK SQ LMNGEDPINNNHAQTAGLGVRLATSSSSRDPSPSDEDMDGEVEILGFKMPTEERVRKRKE SQ SNRESARRSRYRKAAHLKELEDQVAQLKAENSCLLRRIAALNQKYNDANVDNRVLRADME SQ TLRAKVKMGEDSLKRVIEMSSSVPSSMPISAPTPSSDAPVPPPPIRDSIVGYFSATAADD SQ DASVGNGFLRLQAHQEPASMVVGGTLSATEMNRVAAATHCAGAMELIQTAMGSMPPTSAS SQ GSTPPPQIMSCWVQMGPYTWTCIRHCGFRDRWEHFICRRR XX SC PIR #S06022 XX FT 27 32 missing in 437 AA form [6] and 453 AA form [1]; FT 150 150 Asp in 453 AA form FT 238 238 missing in 453 AA form FT 428 460 replaced with 428-437 in 437 AA form FT 215 233 acidic region (8/19) FT 237 258 basic region FT 260 281 leucine zipper (L4) XX SF 460 AA form of Ref. [2]; SF other reported forms comprise 437 AA/47.1 kDa [6] or 453 AA/49.4 kDa [1]; SF the leucine zipper may extend to 253-295 (L4AL2) XX CP endosperm [6]; XX FF activator [7], [4]; FF weak positive autoregulation of O2 transcription [1]; FF within the O2 mRNA, three upstream open reading frames FF (uORF) have been identified [3]; FF at least the first two of them appear to reduce translation FF efficiency of the O2 mRNA [3]; XX MX M00010; P$O2_01 XX BS R02297; MAIZE$22Z1_01; Quality: 6; maize, Zea mays BS R03024; MAIZE$22Z1_02; Quality: 6; maize, Zea mays BS R02296; MAIZE$22Z2_01; Quality: 6; maize, Zea mays BS R02298; MAIZE$22Z3_01; Quality: 6; maize, Zea mays BS R02299; MAIZE$22Z4_01; Quality: 6; maize, Zea mays BS R02934; MAIZE$B32_01; Quality: 6; maize, Zea mays BS R02935; MAIZE$B32_02; Quality: 6; maize, Zea mays BS R02936; MAIZE$B32_03; Quality: 6; maize, Zea mays BS R02937; MAIZE$B32_04; Quality: 6; maize, Zea mays BS R02938; MAIZE$B32_05; Quality: 6; maize, Zea mays BS R02300; MAIZE$PML1_01; Quality: 6; maize, Zea mays BS R02301; MAIZE$PML2_01; Quality: 6; maize, Zea mays BS R02302; MAIZE$Z7_01; Quality: 6; maize, Zea mays BS R02303; MAIZE$ZA1_01; Quality: 6; maize, Zea mays BS R02939; O2$CONS; Quality: 6 XX DR EMBL: X16618; ZMO2(r). DR EMBL: X15544; ZMOPA2(g). DR EMBL: M29411; ZMOPAQ2A(r). DR SwissProt: P12959; OP2_MAIZE. DR PIR: S06022; S06022. XX RN [1] RA Maddaloni M., Fonzo N.D., Hartings H., Lazzaroni N., RA Salamini F., Thompson R., Motto M. RT The sequence of the zein regulatory gene opaque-2 (O2) of Zea Mays RL Nucleic Acids Res. 17:7532-7532 (1989). RN [2] RA Hartings H., Maddaloni M., Lazzaroni N., Di Fonzo RA N., Motto M., Salamini F., Thompson R. D. RT The O2 gene which regulates zein deposition in maize RT endospermencodes a protein with structural homologies RT to transcriptional activators RL EMBO J. 8:2795-2801 (1989). RN [3] RA Lohmer S., Maddaloni M., Motto M., Salamini F., Thompson R. D. RT Translation of the mRNA of the maize transcriptional RT activator Opaque-2 is inhibited by upstream open reading RT frames present in the leader sequence RL Plant Cell 5:65-73 (1993). RN [4] RA Lohmer S., Maddaloni M., Motto M., Di Fonzo N., Hartings RA H., Salamini F., Thompson R. D. RT The maize regulatory locus Opaque-2 encodes a DNA-binding RT protein which activates the transcription of the b-32 gene RL EMBO J. 10:617-624 (1991). RN [5] RA Aukerman M. J., Schmidt R. J., Burr B., Burr F. A. RT An arginine to lysine substitution in the bZIP domain RT of an opaque-2 mutant in maize abolishes specific DNA binding RL Genes Dev. 5:310-320 (1991). RN [6] RA Schmidt R. J., Burr F. A., Aukerman M. J., Burr B. RT Maize regulatory gene opaque-2 encodes a protein with RT a leucine-zipper motif that binds to zein DNA RL Proc. Natl. Acad. Sci. USA 87:46-50 (1990). RN [7] RA Schmidt R. J., Ketudat M., Aukerman M. J., Hoschek G. RT Opaque-2 is a transcriptional activator that recognizes RT a specific target site in 22-kD zein genes RL Plant Cell 4:689-700 (1992). XX // AC T00669 XX ID T00669 XX DT 07.11.92 (created); ewi. DT 04.06.96 (updated); ewi. XX FA Ovo XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.2.5. XX SZ 1209 AA; 1028 AA; 110.6 kDa XX SQ MGGGRDGRGNYGPNSPPTGALPPFYESLKSGQQSTASNNTGQSPGANHSHFNANPANFLQ SQ NAAAAAYIMSAGSGGGGCTGNGGGGASGPGGGPSANSGGGGGGGGGNGYINCGGVGGPNN SQ SLDGNNLLNFASVSNYNESNSKFHNHHHHHQHNNNNNNNGGQTSMMGHPFYGGNPSAYGI SQ ILKDEPDIEYDEAKIDIGTFAQNIIQATMGSSGQFNASAYEDAIMSDLASSGQCPNGAVD SQ PLQFTATLMLSSQTDHLLEQLSDAVDLSSFLQRSCVDDEESTSPRQDFELVSTPSLTPDS SQ VTPVEQHNTNTTQLDVLHENLLTQLTHNIVRGGSNQQQQHHQQHGVQQQQQQQHSVQQQQ SQ QHNVQQQHGVQQQHVQQQPPPSYQHATRGLMMQQQPQHGGYQQQAAIMSQQQQQLLSQQQ SQ QQSHHQQQQQQQHAAAYQQHNIYAQQQQQQQQQHHQQQQHHHFHHQQQQQPQPQSHHSHH SQ HGHGHDNSNMSLPSPTAAAAAAAAAAAAAAAAAAAAAHLQRPMSSSSSSGGTNSSNSSGG SQ SSNSPLLDANAAARAAAALLDTKPLIQSVSNPIGQPLNTQSQQQKQGQQITLMKTTRYTE SQ FVEMVSMDVTVKPELFSELKPEMTEITAEELTLEAETTAAAAAAAAAAAAATTTSATEGT SQ QVLAAAPAPLSSGRKLRGRAKAVAYGSTMITLISTLKSSPEVPATKTVHRTTLRSLATAA SQ AATAAGLLAPSPTVSVLNESKVLQRRLGLPPDLQLEFVNGGHGIKNPLAVENAHGGHHRI SQ RNIDCIDDLSKHGHHSQHQQQQGSPQQQNMQQSVQQQSVQQQQSLQQQQQQQHHQHHSNS SQ SASSNASSHGSAEALCMGSSGGANEDSSSGNNKFVCRVCMKTFSLQRLLNRHMKCHSDIK SQ RYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYA SQ YKERRAKMYVCEECGHTTCEPEVHYLHLKNNHPFSPALLKFYDKRHFKFTNSQFANNLLG SQ QLPMPVHN XX SC translated from EMBL/GenBank/DDBJ #U11383 XX SF 4 zinc finger motifs SF 2 glutamine-rich region, alanine-rich region XX CP nurse cells XX FF regulates female germ line development, maintenance and gametogenesis XX DR EMBL: U11383; DM11383(r). DR EMBL: X59772; DMOVO(g). DR Flybase: FBgn0003028; ovo. XX RN [1] RA Mevel-Ninio M., Terracol R., Kafatos F. C. RT The ovo gene of Drosophila encodes a zinc finger protein RT required for female germ line development RL EMBO J. 10:2259-2266 (1991). XX // AC T00670 XX ID T00670 XX DT 15.10.92 (created); ewi. XX FA P1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01348; RAT$S14_01; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Wong N. C. W., Perez-Castillo A. M., Sanders M. M., RA Schwartz H. L., Oppenheimer J. H. RT Thyroid Hormone and Circadian Regulation of the Binding RT Activity of a Liver-specific Protein Associated with RT the 5'-Flanking Region of the S14 Gene RL J. Biol. Chem. 264:4466-4470 (1989). XX // AC T00671 XX ID T00671 XX DT 14.04.93 (created); ewi. DT 07.02.97 (updated); ewi. XX FA p53 XX SY ASp53; NSp53; RSp53; p53as; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 4.2.1.0.1.1. XX SZ 393 AA; 43.7 kDa (cDNA), 53 kDa (SDS) XX SQ MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP SQ DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK SQ SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE SQ RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS SQ SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP SQ PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG SQ GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD XX SC SwissProt #P04637 XX FT 1 40 trans-activation domain 1 [27], [39], [18]; FT 1 52 Mdm-2-binding [54]; FT 2 68 acidic region (17/67) FT 20 57 TBP-binding [75], [53], [67]; FT 15 15 serine phosphorylated by DNA-PK [48]; FT 37 37 serine phosphorylated by DNA-PK [48]; FT 43 73 trans-activation domain 2 [18]; FT 93 160 transcription inhibiting region [53]; FT 94 293 T-Ag-binding [52]; FT 106 292 DNA-binding domain [9], [57]; FT 323 355 tetramerization domain [57], [63], [66], [68]; FT 315 315 serine phosphorylated by p34cdc2 kinase [44]; FT 319 393 TBP-binding [67]; FT 347 393 unspecific DNA-binding domain [34], [57]; XX SF many mutants found, most of them in transformed cells [3], [32]; SF the DNA-binding domain (DBD) comprises a beta-sandwich SF structure serving as scaffold for two large loops SF and a loop-sheet-helix motif [15]; SF the N-terminal of the three loops (112-124) performs SF extensive major groove contacts in the flanks of the SF consensus binding site (RRRCWWGYYY), whereas the C-terminal SF loop (236-251) binds to the minor groove of the A/T-rich center [15]; SF here, Arg-248 is the most frequently mutated residue SF the alpha-helix at the C-terminal end of the DBD makes SF additional major groove contacts [15]; SF a zinc ion is bound by Cys-176, His-179 (within a SF loop-helix motif), Cys-238 and Cys-242 (within the SF C-terminal loop), but they do not constitute a zinc finger [15]; SF C-terminal part of the molecule: unspecific DNA-binding SF [34], general regulatory domain allosterically masking SF the DNA-binding activity of p53 [8], [20]; SF interaction with short DNA-fragments [22] or E1A [67]; SF p53 may exist and bind to DNA as monomer, dimer or (mostly) tetramer [12]; SF the isolated DBD may aggregate [66]; SF the tetramer is formed as a dimer of dimers, the primary SF dimer being constituted by two antiparallel structures SF of one alpha-helix and one beta-strand from each subunit [13], [16]; SF two dimers interact through their alpha-helices which SF form a four-helix-bundle with antiparallel orientation SF of the adjacent helices [13], [16]; SF e. g., Arg-337 and Phe-341 are responsible for primary SF dimerization, and other side chains such as Leu-344 SF for association of the dimers [68]; SF trans-activation domain is in the N-terminal part SF of the molecule [27], [39]; SF some hydrophobic side chains of this region are responsible SF for activation (Leu-22, Trp-23), for interaction with SF Mdm-2 (Leu-14, Phe-19, Leu-22, Trp-23), and for binding SF of adenoviral E1B (Leu-22, Trp-23, Pro-27) [65]; SF wild-type p53, but not some mutants interact with SF proteins 53BP1 and 53BP2 through its DBD [60]; XX FF activator [27], [37], [39], tumor suppressor [36], FF [32], sequence-specific DNA-binding protein [33], [35], [1]; FF mutants may be deficient in cell control [3], [32] FF and may even inhibit wild-type p53 [43]; FF growth suppression, but not suppression of transformation FF by p53 depends on the trans-activation potential [61], [62]; FF high levels may cause apoptosis [45]; FF required for cells to pass the G1-S chackpoint [38], FF [41] blocking this transition in, e. g., radiation-damaged cells [38]; FF negative regulation of the tumor suppressor Rb [6]; FF binds to the E2F constituents E2F-1 and DP-1 thus FF inhibiting cell cycle promotion by E2F [19]; FF inhibits DNA replication, probably by binding to replication FF factor RPA [50], [55]; FF cooperative DNA-binding with TBP/TFIID [10]; FF strength of TBP-binding corresponds to trans-activation efficiency [18]; FF two TBP-binding regions, interaction with the C-terminal FF part may be responsible for its repressing effect [67]; FF interaction of the trans-activation domain with TAFII40 and TAFII60 [21]; FF also binds to RNA and has RNA-RNA and DNA-DNA annealing activity [56]; FF p53 promoter is activated by c-Myc/Max heterodimers [4]; FF several viral regulators shut off cell cycle control FF by p53 [28], [37], [29], [42], [7], e. g. by accelerating FF its degradation through the ubiquitin pathway [30], [51]; FF inhibitory interactions have been shown with Mdm-2 [46], [47], [49], [58]; FF p53 phosphorylation causes activation of the masked DBD [8]; FF kinases that are active during S and G2 phase may FF phosphorylate p53 [40], [44], [17]; XX IN T00671; p53; human, Homo sapiens. IN T00788; T-Ag; SV40, simian virus 40. IN T00794; TBP; human, Homo sapiens. IN T00796; TBP; mouse, Mus musculus. IN T01542; E2F-1; human, Homo sapiens. IN T01548; DP-1; human, Homo sapiens. XX MX M00034; V$P53_01 XX BS R04099; AS$P53_01; Quality: 3 BS R04384; HS$RBG_01; Quality: 6; human, Homo sapiens BS R04388; HS$RBG_05; Quality: 6; human, Homo sapiens XX DR EMBL: X02469; HSP53(r). DR EMBL: X01405; HSP53R(r). DR EMBL: K03199; HSP53T(r). DR SwissProt: P04637; P53_HUMAN. DR PIR: A25224; A25224. DR PIR: A25397; A25397. DR PIR: B25397; B25397. DR PDB: 1olg; HUMAN P53 (OLIGOMERIZATION DOMAIN). DR PDB: 1olh; HUMAN P53 (OLIGOMERIZATION DOMAIN). DR PDB: 1pes; HUMAN P53 (TETRAMERIZATION DOMAIN). DR PDB: 1pet; HUMAN P53 (TETRAMERIZATION DOMAIN). DR PDB: 1sae; OLIGOMERIZATION DOMAIN OF HUMAN P53 BY NMR. DR PDB: 1saf; OLIGOMERIZATION DOMAIN OF HUMAN P53 BY NMR. DR PDB: 1sag; OLIGOMERIZATION DOMAIN OF HUMAN P53 BY NMR. DR PDB: 1sah; OLIGOMERIZATION DOMAIN OF HUMAN P53 BY NMR. DR PDB: 1sai; OLIGOMERIZATION DOMAIN OF HUMAN P53 BY NMR. DR PDB: 1sak; OLIGOMERIZATION DOMAIN OF HUMAN P53 BY NMR. DR PDB: 1sal; OLIGOMERIZATION DOMAIN OF HUMAN P53 BY NMR. DR PDB: 1tup; HUMAN TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA. XX RN [1] RA Funk W. D., Pak D. T., Karas R. H., Wright W. E., Shay J. W. RT A transcriptionally active DNA-binding site for human p53 protein complexes RL Mol. Cell. Biol. 12:2866-2871 (1992). RN [2] RA El-Deiry W. S., Tokino T., Velculescu V. E., Levy RA D. B., Parsons R., Trent J. M., Lin D., Mercer W. RA E., Kinzler K. W., Vogelstein B. RT WAF1, a potential mediator of p53 tumor suppression RL Cell 75:817-825 (1993). RN [3] RA Hollstein M., Sidransky D., Vogelstein B., Harris C. C. RT p53 mutations in human cancers RL Science 253:49-53 (1991). RN [4] RA Roy B., Beamon J., Balint E., Reisman D. RT Transactivation of the human p53 tumor suppressor RT gene by c-Myc/Max contributes to elevated mutant p53 RT expression in some tumors RL Mol. Cell. Biol. 14:7805-7815 (1994). RN [5] RA Osifchin N. E., Jiang D., Ohtani-Fujita N., Fujita RA T., Carroza M., Kim S.-J., Sakai T., Robbins P. D. RT Identification of a p53 binding site in the human RT retinoblastoma susceptibility gene promoter RL J. Biol. Chem. 269:6383-6389 (1994). RN [6] RA Shiio Y., Yamamoto T., Yamaguchi N. RT Negative regulation of Rb expression by the p53 gene product RL Proc. Natl. Acad. Sci. USA 89:5206-5210 (1992). RN [7] RA Zhang Q., Gutsch D., Kenney S. RT Functional and physical interaction between p53 and RT BZLF1: implications for Epstein-Barr virus latency RL Mol. Cell. Biol. 14:1929-1938 (1994). RN [8] RA Hupp T. R., Meek D. W., Midgley C. A., Lane D. P. RT Activation of the cryptic DNA binding function of mutant forms of p53 RL Nucleic Acids Res. 21:3167-3174 (1993). RN [9] RA Pavletich N. P., Chambers K. A., Pabo C. O. RT The DNA-binding domain of p53 contains the four conserved RT regions and the major mutation hot spots RL Genes Dev. 7:2556-2564 (1993). RN [10] RA Chen X., Farmer G., Zhu H., Prywes R., Prives C. RT Cooperative DNA binding of p53 TFIID (TBP): a possible RT mechanism for transcriptional activation RL Genes Dev. 7:1837-1849 (1993). RN [11] RA Martin D. W., Munoz R. M., Subler M. A., Deb S. RT p53 binds to the TATA-binding protein-TATA complex RL J. Biol. Chem. 268:13062-13067 (1993). RN [12] RA Friedman P. N., Chen X., Bargonetti J., Prives C. RT The p53 protein is an unusually shaped tetramer that binds directly to DNA RL Proc. Natl. Acad. Sci. USA 90:3319-3323 (1993). RN [13] RA Clore G. M., Omichinski J. G., Sakaguchi K., Zambrano RA N., Sakamoto H., Appella E., Gronenborn A. M. RT High-resolution structure of the oligomerization domain RT of p53 by multidimensional NMR RL Science 265:386-391 (1994). RN [14] RA Thukral S. K., Blain G. C., Chang K. K. H., Fields S. RT Distinct residues of human p53 implicated in binding RT to DNA, simian virus 40 T antigen, 53BP1, and 53BP2 RL Mol. Cell. Biol. 14:8315-8321 (1994). RN [15] RA Cho Y., Gorina S., Jeffrey P. D., Pavletich N. P. RT Crystal structure of a p53 tumor suppressor-DNA complex: RT Understanding tumorigenic mutations RL Science 265:346-355 (1994). RN [16] RA Jeffrey P. D., Gorina S., Pavletich N. P. RT Crystal structure of the tetramerization domain of RT the p53 tumor suppressor at 1.7 Angstroms RL Science 267:1498-1502 (1995). RN [17] RA Wang Y., Prives C. RT Increased and altered DNA binding of human p53 by RT S and G2/M but not G1 cyclin-dependent kinases RL Nature 376:88-91 (1995). RN [18] RA Chang J., Kim D.-H., Lee S. W., Choi K. Y., Sung Y. C. RT Transactivation ability of p53 transcriptional activation RT domain is directly related to the binding affinity to TATA-binding protein RL J. Biol. Chem. 270:25014-25019 (1995). RN [19] RA Connor D. J., Lam E. W.-F., Griffin S., Zhong S., RA Leighton L. C., Burbidge S. A., Liu X. RT Physical and functional interactions between p53 and RT cell-cycle co-operating transcriptional factors, E2F1 and DP1 RL EMBO J. 14:6184-6192 (1995). RN [20] RA Hupp T. R., Sparks A., Lane D. P. RT Small peptides activate the latent sequence-specific RT DNA binding function of p53 RL Cell 83:237-245 (1995). RN [21] RA Thut C. J., Chen J.-L., Klemm R., Tjian R. RT p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60 RL Science 267:100-104 (1995). RN [22] RA Jayaraman L., Prives C. RT Activation of p53 Sequence-Specific DNA Binding by RT Short Single Strands of DNA Requires the p53 C.Terminus RL Cell 81:1021-1029 (1995). RN [23] RA Matlashewski G., Lamb P., Pim D., Peacock J., Crawford L., Benchimol S. RT Isolation and characterization of a human p53 cDNA RT clone: Expression of the human p53 gene RL EMBO J. 3:3257-3262 (1984). RN [24] RA Zakut-Houri R., Bienz-Tadmor B., Givol D., Oren M. RT Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells RL EMBO J. 4:1251-1255 (1985). RN [25] RA Harlow E., Williamson N. M., Ralston R., Helfman D. M., Adams T. E. RT Molecular cloning and in vitro expression of a cDNA RT clone for human cellular tumor antigen p53 RL Mol. Cell. Biol. 5:1601-1610 (1985). RN [26] RA McBride O. W., Merry D., Givol D. RT The gene for human p53 cellular tumor antigen is located RT on chromosome 17 short arm (17p13) RL Proc. Natl. Acad. Sci. USA 83:130-134 (1986). RN [27] RA Fields S., Jang S. K. RT Presence of a potent transcription activation sequence in the p53 protein RL Science 249:1046-1049 (1990). RN [28] RA Lin J.-Y., Simmons D. T. RT The ability of large T anigen to complex with p53 RT is necessary for the increased life span and partial RT transformation of human cells by simian virus 40 RL J. Virol. 65:6447-6453 (1991). RN [29] RA Huibregtse J. M., Scheffner M., Howley P. M. RT A cellular protein mediates association of p53 with RT the E6 oncoprotein of human papillomavirus types 16 or 18 RL EMBO J. 10:4129-4135 (1991). RN [30] RA Scheffner M., Werness B. A., Huibregtse J. M., Levine A. J., Howley P. M. RT The E6 oncoprotein encoded by human papillomavirus RT types 16 and 18 promotes the degradation of p53 RL Cell 63:1129-1136 (1990). RN [31] RA Linzer D. I. H., Levine A. J. RT Characterization of a 54K dalton cellular SV40 tumor RT antigen present in SV40-transformed cells and uninfected RT embryonal carcinoma cells RL Cell 17:43-52 (1979). RN [32] RA Levine A. J., Momand J., Finlay C. A. RT The p53 tumour suppressor gene RL Nature 351:453-457 (1991). RN [33] RA Bargonetti J., Friedman P. N., Kern S. E., Vogelstein B., Prives C. RT Wild-type but not mutant p53 immunopurified proteins RT bind to sequences adjacent to the SV40 origin of replication RL Cell 65:1083-1091 (1991). RN [34] RA Foord O. S., Bhattacharya P., Reich Z., Rotter V. RT A DNA binding domain is contained in the C-terminus of wild-type p53 protein RL Nucleic Acids Res. 19:5191-5198 (1991). RN [35] RA Kern S. E., Kinzler K. W., Bruskin A., Jarosz D., RA Friedman P., Prives C., Vogelstein B. RT Identification of p53 as a sequence-specific DNA-binding protein RL Science 252:1708-1711 (1991). RN [36] RA Weinberg R. A. RT Tumor suppressor genes RL Science 254:1138-1146 (1991). RN [37] RA Farmer G., Bargonetti J., Zhu H., Friedman P., Prywes R., Prives C. RT Wild-type p53 activates transcription in vitro RL Nature 358:83-86 (1992). RN [38] RA Kastan M. B., Zhan Q., El-Deiry W. S., Carrier F., RA Jacks T., Walsh W. V., Plunkett B. S., Vogelstein B., Fornace A. J., jr. RT A mammalian cell cycle checkpoint pathway utilizing RT p53 and GADD45 is defective in ataxia-telangiectasia RL Cell 71:587-597 (1992). RN [39] RA Unger T., Nau M. M., Segal S., Minna J. D. RT p53: A transdominant regulator of transcription whose RT function is ablated by mutations occurring in human cancer RL EMBO J. 11:1383-1390 (1992). RN [40] RA Nigro J. M., Sokorski R., Reed S. I., Vogelstein B. RT Human p53 and CDC2Hs genes combine to inhibit the RT proliferation of Saccharomyces cerevisiae RL Mol. Cell. Biol. 12:1357-1365 (1992). RN [41] RA Lin D., Shields M. T., Ullrich S. J., Appella E., Mercer W. E. RT Growth arrest induced by wild-type p53 protein blocks RT cells prior to or near the restriction point in late G1 phase RL Proc. Natl. Acad. Sci. USA 89:9210-9214 (1992). RN [42] RA Lechner M. S., Mack D. H., Finicle A. B., Crook T., RA Vousden K. H., Laimins L. A. RT Human papillomavirus E6 proteins bind p53 in vivo RT and abrogate p53-mediated repression of transcription RL EMBO J. 11:3045-3052 (1992). RN [43] RA Kern S. E., Pietenpol J. A., Thiagalingam S., Seymour RA A., Kinzler K. W., Vogelstein B. RT Oncogenic forms of p53 inhibit p53-regulated gene expression RL Science 256:827-830 (1992). RN [44] RA Bischoff J. R., Friedman P. N., Marshak D. R., Prives C., Beach D. RT Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2 RL Proc. Natl. Acad. Sci. USA 87:4766-4770 (1990). RN [45] RA Shaw P., Bovey R., Tardy S., Sahli R., Sordat B., Costa J. RT Induction of apoptosis by wild-type p53 in a human RT colon tumor-derived cell line RL Proc. Natl. Acad. Sci. USA 89:4495-4499 (1992). RN [46] RA Hinds P. W., Finlay C. A., Quartin R. S., Baker S. RA J., Fearon E. R., Vogelstein B., Levine A. J. RT Mutant p53 DNA clones from human colon carcinomas RT cooperate with ras in transforming primary rat cells: RT a comparison of the 'hot spot' mutant phenotypes RL Cell Growth Differ. 1:571-580 (1990). RN [47] RA Momand J., Zambetti G. P., Olson D. C., , Levine D., George A. J. RT the mdm-2 oncogene product forms a complex with the RT p53 protein and inhibits p53-mediated transactivatioN RL Cell 69:1237-1245 (1992). RN [48] RA Lees-Miller S. P., Sakaguchi K., Ullrich S. J., Appella E., Anderson C. W. RT Human DNA-activated protein kinase phosphorylates RT serines 15 and 37 in the amino-terminal transactivation domain of human p53. RL Mol. Cell. Biol. 12:5041-5049 (1992). RN [49] RA Brown D. R., Deb S., Munoz R. M., Subler M. A., Deb S. P. RT The tumor suppressor p53 and the oncoprotein simian RT virus 40 T antigen bind to overlapping domains on the MDM2 protein RL Mol. Cell. Biol. 13:6849-6857 (1993). RN [50] RA Dutta A., Ruppert J. M., Aster J. C., Winchester E. RT Inhibition of DNA replication factor RPA by p53 RL Nature 365:79-82 (1993). RN [51] RA Scheffner M., Huibregtse J. M., Vierstra R. D., Howley P. M. RT The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein RT ligase in the ubiquitination of p63 RL Cell 75:495-505 (1993). RN [52] RA Ruppert J. M., Stillman B. RT Analysis of a protein-binding domain of p53 RL Mol. Cell. Biol. 13:3811-3820 (1993). RN [53] RA Liu X., Miller C. W., Koeffler P. H., Berk A. J. RT The p53 activation domain binds the TATA box-binding RT polypeptide in holo-TFIID, and a neighboring p53 domain RT inhibits transcription RL Mol. Cell. Biol. 13:3291-3300 (1993). RN [54] RA Chen J., Marechal V., Levine A. J. RT Mapping of the p53 and mdm-2 interaction domains RL Mol. Cell. Biol. 13:4107-4114 (1993). RN [55] RA Li R., Botchan M. R. RT The acidic transcriptional activation domains of VP16 RT and p53 bind the cellular replication protein A and RT stimulate in vitro BPV-1 DNA replication RL Cell 73:1207-1221 (1993). RN [56] RA Oberosler P., Hloch P., Rampsberger U., Stahl H. RT p53-catalyzed annealing of complementary single-stranded nucleic acids RL EMBO J. 12:2389-2396 (1993). RN [57] RA Wang Y., Reed M., Wang P., Stenger J. E., Mayr G., RA Anderson M. E., Schwedes J. F., Tegtmeyer P. RT p53 domains: identification and characterization of RT two autonomous DNA-binding regions RL Genes Dev. 7:2575-2586 (1993). RN [58] RA Oliner J. D., Pietenpol J. A., Thiagalingam S., Gyuris RA J., Kinzler K. W., Vogelstein B. RT Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 RL Nature 362:857-860 (1993). RN [59] RA Mack D. H., Vartikar J., Pipas J. M., Laimins L. A. RT Specific repression of TATA-mediated but not initiator-mediated RT transcription by wild-type p53 RL Nature 363:281-283 (1993). RN [60] RA Iwabuchi K., Bartel P. L., Lin B., Marraccino R., Fields S. RT Two cellular proteins that bind to wild-type but not mutant p53 RL Proc. Natl. Acad. Sci. USA 91:6098-6102 (1994). RN [61] RA Pietenpol J. A., Tokino T., Thiagalingam S., El-Deiry RA W. S., Kinzler K. W., Vogelstein B. RT Sequence-specific transcriptional activation is essential RT for growth suppression by p53 RL Proc. Natl. Acad. Sci. USA 91:1998-2002 (1994). RN [62] RA Crook T., Marston N. J., Sara E. A., Vousden K. H. RT Transcriptional activation by p53 correlates with RT suppression of growth but not transformation RL Cell 79:817-827 (1994). RN [63] RA Sakamoto H., Lewis M. S., Kodama H., Appella E., Sakaguchi K. RT Specific sequences from the carboxal terminus of human RT p53 gene product form anti-parallel tetramers in solution RL Proc. Natl. Acad. Sci. USA 91:8974-8978 (1994). RN [64] RA Ueba T., Nosaka T., Takahashi J. A., Shibata F., Florkiewicz RA R. Z., Vogelstein B., Oda Y., Kikuchi H., Hatanaka M. RT Transcriptional regulation of basic fibroblasts growth RT factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells RL Proc. Natl. Acad. Sci. USA 91:9009-9013 (1994). RN [65] RA Lin J., Chen J., Elenbaas B., Levine A. J. RT Several hydrophobic amino acids in the p53 amino-terminal RT domain are required for transcriptional activation, RT binding to mdm-2 and the adenovirus 5 E1B 55-kD protein RL Genes Dev. 8:1235-1246 (1994). RN [66] RA Wang P., Reed M., Wang W., Mayr G., Stenger J. E., RA Anderson M. E., Schwedes J. F., Tegtmeyer P. RT p53 domains: Structure, oligomerization, and transformation RL Mol. Cell. Biol. 14:5182-5191 (1994). RN [67] RA Horikoshi N., Usheva A., Chen J., Levine A. J., Weinmann R., Shenk T. RT Two domains of p53 interact with the TATA-binding RT protein, and the adenovirus 13S E1A protein disrupts RT the association, relieving p53-mediated transcriptional repression RL Mol. Cell. Biol. 15:227-234 (1995). RN [68] RA Waterman J. L. F., Shenk J. L., Halazonetis T. D. RT The dihedral symmetry of the p53 tetramerization domain RT mandates a conformational switch upon DNA binding RL EMBO J. 14:512-519 (1995). RN [69] RA Unger T., Mietz J. A., Scheffner M., Yee C. L., Howley P. M. RT Functional domains of wild-type and mutant p53 proteins RT involved in transcriptional regulation, transdominant RT inhibition, and transformation suppression RL Mol. Cell. Biol. 13:5186-5194 (1993). RN [70] RA Lamb P., Crawford L. RT Characterization of the human p53 gene RL Mol. Cell. Biol. 6:1379-1385 (1986). RN [71] RA Harris N., Brill E., Shohat O., Prokocimer M., Wolf D., Arai N., Rotter V. RT Molecular basis for heterogeneity of the human p53 protein RL Mol. Cell. Biol. 6:4650-4656 (1986). RN [72] RA Buchman V. L., Chumakov P. M., Ninkina N. N., Samarina O. P., Georgiev G. P. RT A variation in the structure of the protein-coding RT region of the human p53 gene RL Gene 70:245-252 (1988). RN [73] RA Addison C., Jenkins J. R., Sturzbecher H. W. RT The p53 nuclear localisation signal is structurally RT linked to a p34cdc2 kinase motif RL Oncogene 5:423-426 (1990). RN [74] RA Harris C. C. RT p53: at the crossroads of molecular carcinogenesis and risk assessment RL Science 262:1980-1981 (1993). RN [75] RA Truant R., Xiao H., Ingles C. J., Greenblatt J. RT Direct interaction between the transcriptional activation RT domain of human p53 and the TATA box-binding protein RL J. Biol. Chem. 268:2284-2287 (1993). XX // AC T00672 XX ID T00672 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA p67 XX SY SRF; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO EBF XX CL C0014; MADS; . XX SZ 67 kDa XX CP (HeLa) XX IN T00043; ARG RI; yeast, Saccharomyces cerevisiae. IN T00250; Elk-1; human, Homo sapiens. IN T00737; SAP-1a; human, Homo sapiens. IN T01413; Net; mouse, Mus musculus. IN T02128; SAP-1b; human, Homo sapiens. XX BS R00460; HS$CFOS_03; Quality: 4; human, Homo sapiens BS R00467; HS$CFOS_10; Quality: 2; human, Homo sapiens BS R02246; SRF$CONS; Quality: 1 XX RN [1] RA Shaw P. E., Schroeter H., Nordheim A. RT The Ability of a Ternary Complex to Form Over the RT Serum Response Element Correlates with Serum Inducibility RT of the Human c-fos Promoter RL Cell 56:563-572 (1989). XX // AC T00673 XX ID T00673 XX DT 15.10.92 (created); ewi. XX FA alpha-PAL XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 66-68 kDa XX BS R01727; HS$EIF2A_01; Quality: 6; human, Homo sapiens XX RN [1] RA Jacob W. F., Silverman T. A., Cohen R. B., Safer B. RT Identification and Characterization of a Novel Transcription RT Factor Participating in the Expression of Eukaryotic RT Initiation Factor 2alpha RL J. Biol. Chem. 264:20372-20384 (1989). XX // AC T00674 XX ID T00674 XX DT 09.12.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA E47 XX SY Pan-1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; 1.2.1.0.1.2. XX SZ 638 AA; 66.4 kDa (cDNA) XX SQ PVGSDKELSDLLDFSMMFPLPVANGKGRPASLAGTQFAGSGLEDRPSSESWGNSEQNSSS SQ FDPSRAYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGTLSQAGFLPG SQ ELGLSSPGPLSPSGVKSSSQYYTSFPSNPRRRAADGGLADTQPKKVRKVPPGLPSSVYPS SQ SSGDNYSRDATAYPSAKTPSSAYPSPFYVADGSLHPSAELWSPPGQVGFGPMLGDGSAPL SQ PLAPGSSSVSSGAFGGLQQQDRMGYQLHGSEVNGTLPAVSSFSAAPGTYSGTSGHTPPVS SQ GADSLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRA SQ GAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASELHGLLPGHSTLTTSFAGPM SQ SLGGRHAGLVSGSHPEDGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSFSGLGRAGVTA SQ GASEIKREEKEDEEVTSVADAEEDKKDLKVPRTRTSSTDEVLSLEEKDLRDRERRMANNA SQ RERVRVRDINEAFRELGRMCQLHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLNPKAA SQ CLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL XX SC SwissProt #P21676 XX FT 377 412 leucine repeat (L3TL2) FT 534 543 basic region FT 544 587 helix-loop-helix domain XX IN T00003; AS-C T3; fruit fly, Drosophila melanogaster. IN T00204; E12; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00404; Id2; mouse, Mus musculus. IN T00506; MEF1; mouse, Mus musculus. IN T00526; MyoD; mouse, Mus musculus. IN T00790; Tal-1; human, Homo sapiens. IN T01212; Id2; human, Homo sapiens. XX BS R00223; RAT$CHYB_01; Quality: 6; rat, Rattus norvegicus XX DR SwissProt: P21676; PAN1_RAT. DR PIR: B35816; B35816. XX RN [1] RA Nelson C., Shen L.-P., Meister A., Fodor E., Rutter W. J. RT Pan: a transcriptional regulator that binds chymotrypsin, RT insulin, and AP-4 enhancer motifs RL Genes Dev. 4:1035-1043 (1990). RN [2] RA Shibasaki Y., Sakura H., Takaku F., Kasuga M. RT Insulin enhancer binding protein has helix-loop-helix structure RL Biochem. Biophys. Res. Commun. 170:314-321 (1990). XX // AC T00675 XX ID T00675 XX DT 09.12.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA E12 XX SY Pan-2; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0010; bHLH; 1.2.1.0.1.1. XX SZ 649 AA; 67.7 kDa (cDNA) XX SQ MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKGRPASLAGTQFAGSGLEDRPSSESW SQ GNSEQNSSSFDPSRAYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGT SQ LSQAGFLPGELGLSSPGPLSPSGVKSSSQYYTSFPSNPRRRAADGGLDTQPKKVRKVPPG SQ LPSSVYPSSSGDNYSRDATAYPSAKTPSSAYPSPFYVADGSLHPSAELWSPPGQVGFGPM SQ LGDGSAPLPLAPGSSSVSSGAFGGLQQQDRMGYQLHGSEVNGTLPAVSSFSAAPGTYSGT SQ SGHTPPVSGADSLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLP SQ GTSQWPRAGAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASELHGLLPGHSTL SQ TTSFAGPMSLGGRHAGLVSGSHPEDGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSFSG SQ LGRAGVTAGASEIKREEKEDEEVTSVADAEEDKKDLKVPRTRTSPDEDEDDLLPPEQKAE SQ REKERRVANNARERLRVRDINEAFKELGRMCQLHLSTEKPQTKLLILHQAVAVILSLEQQ SQ VRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL XX SC SwissProt #P21677 XX FT 545 556 basic region FT 557 598 helix-loop-helix domain XX IN T00003; AS-C T3; fruit fly, Drosophila melanogaster. IN T00036; AP-4; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00403; Id1; mouse, Mus musculus. IN T00484; MASH-1; rat, Rattus norvegicus. IN T00485; MASH-2; rat, Rattus norvegicus. IN T00506; MEF1; mouse, Mus musculus. IN T00512; MRF4; rat, Rattus norvegicus. IN T00521; Myf-5; human, Homo sapiens. IN T00526; MyoD; mouse, Mus musculus. IN T00528; myogenin; mouse, Mus musculus. IN T00926; SUM-1; sea urchin, Lytechinus variegatus. IN T01619; MASH-1; mouse, Mus musculus. XX BS R04046; HS$CFOS_18; Quality: 2; human, Homo sapiens BS R00223; RAT$CHYB_01; Quality: 6; rat, Rattus norvegicus XX DR EMBL: S77532; S77532(r). DR SwissProt: P21677; PAN2_RAT. DR PIR: A35816; A35816. XX RN [1] RA Metz R., Ziff E. RT The helix-loop-helix protein rE12 and the C/EBP-related RT factor rNFIL-6 bind to neighboring sites within the RT c-fos serum response element RL Oncogene 6:2165-2178 (1991). RN [2] RA Nelson C., Shen L.-P., Meister A., Fodor E., Rutter W. J. RT Pan: a transcriptional regulator that binds chymotrypsin, RT insulin, and AP-4 enhancer motifs RL Genes Dev. 4:1035-1043 (1990). XX // AC T00676 XX ID T00676 XX DT 12.03.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Pap1+ XX OS fission yeast, Schizosaccharomyces pombe OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0008; bZIP; 1.1.1.5.5. XX SQ MSGQTETLSSTSNIPIAKAEPEQSADFSASHKKRGPVSDRSSRRTSSEEVDLMPNVDDEV SQ DGDVKPKKIGRKNSDQEPSSKRKAQNRAAQRAFRKRKEDHLKALETQVVTLKELHSSTTL SQ ENDQLRQKVRQLEEELRILKDGSFTFEMSLPHRNPSLSSLPTTGFPSNFAHMKDGISPQS SQ NLHLSPNSIEKPNMHQNVLHNDRSADNLNHRYQVPPTLVDSNSAQGTLSPETPSSSDSPS SQ NLYLNYPKRKSITHLHHDCSALSNGENGEDVADGKQFCQNVSTACGSIACSMLTKTTPHR SQ ASVDILSNLHESTVSPPMADESVQRSSEVSKSIPNVELSLNVNQQFVSPFGGTDSFPLPT SQ DTGLDSLFEPDSAIENSHLKNVVMEPELFQAWREPAESLDKEFFNDEGEIDAVFHNYFHN SQ SNENGDLITNSLHGLDFLENANESFPEQMYPFIKHNKDYISNHPDEVPPDGLPQKGKHDT SQ SSQMPSENEIVPAKERAYLSCPKVWSKIINHPRFESFDIDDLCSKLKNKAKCSSSGVLLD SQ ERRC XX SC SwissProt #Q01663 XX FF confers staurosporine resistance; FF different from GCN4 or YAP1 XX BS R00235; HS$CLASE_01; Quality: 6; human, Homo sapiens BS R01383; SV$SV40_15; Quality: 6; SV40, simian virus 40 XX DR EMBL: X57078; SPPAP1(g). DR SwissProt: Q01663; AP1_SCHPO. DR PIR: S15664; S15664. XX RN [1] RA Toda T., Shimanuki M., Yanagida M. RT Fission yeast gene that confer resistance to staurosporine RT encode an AP-1-like transcription factor and a protein RT kinase related to the mammalian ERK1/MAP2 and budding RT yeast FUS3 and KSS1 kinases RL Genes Dev. 5:60-73 (1991). XX // AC T00677 XX ID T00677 XX DT 16.12.92 (created); ewi. DT 17.05.96 (updated); ewi. XX FA Pax-1 XX SY HuP48 (human); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO Pox meso, P29 (Drosophila) XX CL C0017; paired; 3.2.2.0.1. XX SZ 361 AA; 37.9 kDa (cDNA); 42 kDa (SDS) XX SQ MEQTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARY SQ NETGSILPGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSV SQ SSISRILRNKIGSLAQPGPYEASKQPPPQPALPYNHIYQYPYPSPVSPTGTKMGTHPGVP SQ GSAGHVSIPRSWPSAHSVSNILGIRTFMEQTGALTGSEGAAYSPKMEDWAGVNRAAFPTS SQ PAVNGLEKPALEADIKYTQLASSLSAVGGFLPACAYPASNQQGVYSAPAAGYLSPGPPWP SQ PAQAPPLTPHGAGVAVHGGELAAAMTFKHREGTDRKPPSPGGKATDALGSLHGLPIPAST SQ S XX SC SwissProt #P09084 XX FT 4 128 paired domain FT 137 180 proline-rich region (13/44) FT 272 309 proline-rich region (11/38) XX SF no homeo domain SF pI(calc) = 10.1 SF XX CP perichordal zone of the developing vertebral column [4]; XX FF activator [2]; FF involved in control of embryogenesis [1]; FF oncogenic potential, depending on an intact paired domain [1]; FF mutations may cause Undulated phenotype, e. g. G18S FF within the paired domain [3] decreasing DNA-binding FF affinity and changing sequence specificity [2]; XX BS R02802; AS$PAX1_01; Quality: 6 BS R02803; AS$PAX1_02; Quality: 6 BS R02804; AS$PAX1_03; Quality: 6 BS R02805; AS$PAX1_04; Quality: 6 BS R02806; AS$PAX1_05; Quality: 6 BS R02807; AS$PAX1_06; Quality: 6 BS R02808; AS$PAX1_07; Quality: 6 BS R02230; PAX1$CONS; Quality: 6 XX DR EMBL: M20978; MMHBPAXA(g). DR EMBL: M69222; MMPAX1A(r). DR SwissProt: P09084; PAX1_MOUSE. DR PIR: A29902; A29902. DR PIR: A40023; A40023. XX RN [1] RA Maulbecker C. C., Gruss P. RT The oncogenic potential of Pax genes RL EMBO J. 12:2361-2367 (1993). RN [2] RA Chalepakis G., Fritsch R., Fickenscher H., Deutsch U., Goulding M., Gruss P. RT The molecular basis of the undulated/Pax-1 mutation RL Cell 66:873-884 (1991). RN [3] RA Balling R., Deutsch U., Gruss P. RT undulated, a mutation affecting the development of RT the mouse skeleton, has a point mutation in the paired box of Pax 1 RL Cell 55:531-535 (1988). RN [4] RA Deutsch U., Dressler G. R., Gruss P. RT Pax 1, a member of a paired box homologous murine RT gene family, is expressed in segmented structures during development RL Cell 53:617-625 (1988). XX // AC T00678 XX ID T00678 XX DT 16.12.92 (created); ewi. DT 17.05.96 (updated); ewi. XX FA Pax-2a XX SY Pax-2; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0017; paired; 3.2.2.0.2. XX SZ 415 AA; 44.8 kDa (gene), 48 kDa (SDS) XX SQ MDMHCKADPFSAMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVS SQ HGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAE SQ GICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDP SQ VGSYSINGILGIPRSNGEKRKREEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQ SQ SGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLD SQ EVKSSLSASANPELGSNVSGTQTYPVVTGRDMTSTTLPGYPPHLPPTGQGSYPTSTLAGM SQ VPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRSAPAARAAAYDRH XX SC SwissProt #P32114 XX FT 15 140 paired domain FT 204 228 missing in Pax-2b XX SF a splice variant is Pax-2b [5]; SF Pax-2 comprises a remnant of a homeo domain XX CP condensing mesenchyme cells & their epithelial derivatives CP in the developing kidney [5]; XX FF active during mesenchyme-to-epithelium transition FF in early kidney development [5]; FF overexpresed in Wilms tumor [5]; FF oncogenic potential [1]; XX MX M00098; V$PAX2_01 XX BS R02801; DROME$EVE_32; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: U13975; MM13975(g). DR EMBL: X55781; MMPAX2(g). DR SwissProt: P32114; PAX2_MOUSE. DR PIR: A60086; A60086. XX RN [1] RA Maulbecker C. C., Gruss P. RT The oncogenic potential of Pax genes RL EMBO J. 12:2361-2367 (1993). RN [2] RA Ryan G., Steele-Perkins V., Morris J. F., Rauscher F. J., Dressler G. R. RT Repression of Pax-2 by WT1 during normal kidney development RL Development 121:867-875 (1995). RN [3] RA Dressler G. R., Deutsch U., Chowdhury K., Nornes H. O., Gruss P. RT Pax2, a new murine paired-box-containing gene and RT its expression in the developing excretory system RL Development 109:787-795 (1990). RN [4] RA Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek RA P., Maurer-Fogy I., Busslinger M. RT Pax-5 encodes the transcription factor BSAP and is RT expressed in B lymphocytes, the developing CNS, and adult testis RL Genes Dev. 6:1589-1607 (1992). RN [5] RA Dressler G. R., Douglass E. C. RT Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor RL Proc. Natl. Acad. Sci. USA 89:1179-1183 (1992). XX // AC T00679 XX ID T00679 XX DT 16.12.92 (created); ewi. DT 17.03.97 (updated); ewi. XX FA Pax-3 XX SY HuP2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0018; paired-homeo; 3.2.1.0.2. XX SZ 479 AA; 53.0 kDa (gene) XX SQ MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIV SQ EMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEE SQ YKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEES SQ EKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFER SQ THYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMP SQ TLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNPDSSSAYCLPSTR SQ HGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLE SQ PTTTVSASCSQRLDHMKSLDSLPTSQSYCPPTYSTTGYSMDPVTGYQYGQYGQSKPWTF XX SC SwissProt #P23760 XX FT 34 159 paired domain FT 219 278 homeo domain FT 291 478 proline-/serine-/threonine-rich region (83/188) FT 196 479 replaced by 196-215 in Pax-3A [5]; FT 196 479 replaced by 196-206 in Pax-3B [5]; XX SF paired domain of the Paired-Gooseberry class [1]; SF alternative splice variants Pax-3A and -3B that lack the homeo domain [5]; SF chromosomal translocation t(2 SF 13)(q35 SF q14) causing alveaolar rhabdomyosarcomas fuses Pax-3(1-391) SF with fork head domain of FKHR [1]; SF mutants causing Waardenburg syndrome are altered in SF DNA-binding or homodimerization SF heterodimerization with Pax-7 upon binding to palindromic SF homeo domain recognition sites [4]; XX FF activator, enhanced activation potential in PAX3-FKHR fusion protein [2]; FF mutations may cause Waardenburg's syndrome (sensorineural FF deafness, pigmentary abnormalities in iris and hair, eye displacement) [3]; XX IN T00396; Pax-7; human, Homo sapiens. XX DR EMBL: M85237; HSHOMP(g). DR EMBL: X15043; HSHUP2A(g). DR EMBL: X15252; HSHUP2B(g). DR EMBL: X15253; HSHUP2C(g). DR SwissProt: P23760; PAX3_HUMAN. DR PIR: S06960; S06960. XX RN [1] RA Shapiro D. N., Sublett J. E., Li B., Downing J. R., Naeve C. W. RT Fusion of PAX3 to a member of the forkhead family RT of transcription factors in human alveolar rhabdomyosarcoma RL Cancer Res. 53:5108-5112 (1993). RN [2] RA Galili N., Davis R. J., Fredericks W. J., Mukhopadhyay RA S., Rauscher III F. J., Emanuel B. S., Rovera G., Barr F. G. RT Fusion of a fork head domain to PAX-3 in the solid RT tumor alveolar rhabdomyosarcoma RL Nature Genet. 5:230-235 (1993). RN [3] RA Chalepakis G., Goulding M., Read A., Strachan T., Gruss P. RT Molecular basis of splotch and Waardenburg Pax-3 mutations RL Proc. Natl. Acad. Sci. USA 91:3685-3689 (1994). RN [4] RA Schaefer B. W., Czerny T., Bernasconi M., Genni M., Busslinger M. RT Molecular cloning and characterization of a human RT PAX-7 cDNA expressed in normal and neoplastic myocytes RL Nucleic Acids Res. 22:4574-4582 (1994). RN [5] RA Tsukamoto K., Nakamura Y., Niikawa N. RT Isolation of two isoforms of the PAX3 gene transcripts RT and their tissue-specific alternative expression in human adult tissues RL Hum. Genet. 93:270-274 (1994). RN [6] RA Tassabehji M., Read A. P., Newton V. E., Harris R., RA Balling R., Gruss P., Strachan T. RT Waardenburg's syndrome patients have mutations in RT the human homologue of the Pax-3 paired box gene RL Nature 355:635-636 (1992). RN [7] RA Baldwin C. T., Hoth C. F., Amos J. A., da-Silva E. O., Milunsky A. RT An exonic mutation in the HuP2 paired domain gene RT causes Waardenburg's syndrome RL Nature 355:637-638 (1992). RN [8] RA Burri M., Tromvoukis Y., Bopp D., Frigerio G., Noll M. RT Conservation of the paired domain in metazoans and RT its structure in three isolated human genes RL EMBO J. 8:1183-1190 (1989). XX // AC T00680 XX ID T00680 XX DT 16.12.92 (created); ewi. DT 15.05.96 (updated); ewi. XX FA Pax-3 XX SY HuP2 (human); XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0018; paired-homeo; 3.2.1.0.2. XX SZ 479 AA; 53.0 kDa (cDNA), 56 kDa (SDS) [11]; XX SQ MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIV SQ EMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEE SQ YKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEES SQ EKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFER SQ THYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMP SQ TLPTYQLSEHSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNADSSSAYCLPSTR SQ HGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLE SQ PTTTVSASCSQRLEHMKNVDSLPTSQPYCPPTYSTAGYSMDPVTGYQYGQYGQSKPWTF XX SC SwissProt #P24610 XX FT 1 90 transcription inhibiting region [5]; FT 34 159 paired domain FT 219 278 homeo domain FT 291 478 proline-/serine-/threonine-rich region (79/188) FT 402 479 transcription activating region [5]; XX SF independent DNA-binding by paired and homeo domain SF contacting ATTA and GTTCC motifs, resp. [3]; SF variable spacing of the subsites [4]; SF paired domain induces conformational change in the DNA [3]; SF homodimerization upon DNA-binding through residues SF between paired and homeo domain [3]; SF altered DNA-binding or homodimerization in Splotch mutants [3]; XX CP 8.5-d embryos: mitotic cells in the ventricular zone CP of developing spinal chord; some regions in hindbrain, CP midbrain, diencephalon; 10-12-d embryos: also neural CP crest of developing spinal ganglia, cranofacial mesectoderm, CP limb mesenchyme (10-11 d) [11]; XX FF activator (fused to GAL4-DNA binding domain) [5]; FF mutations may cause Splotch (pigmentation abnormalities FF in iris and hair, eye displacement, exencephaly, spina FF bifida, lack of limb musculature) [9], [10], e. g. FF G42R [3] or point mutation causing aberrant splicing [1]; FF expression is detected between embryonic day 8.5 and 14.5 [11], [7], [8]; XX IN T00680; Pax-3; mouse, Mus musculus. XX BS R02801; DROME$EVE_32; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: X59358; MMPAX3R(r). DR SwissProt: P24610; PAX3_MOUSE. DR PIR: S15031; S15031. XX RN [1] RA Epstein D. J., Vogan K. J., Trasler D. G., Gros P. RT A mutation within intron 3 of the Pax-3 gene produces RT aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant RL Proc. Natl. Acad. Sci. USA 90:532-536 (1993). RN [2] RA Maulbecker C. C., Gruss P. RT The oncogenic potential of Pax genes RL EMBO J. 12:2361-2367 (1993). RN [3] RA Chalepakis G., Goulding M., Read A., Strachan T., Gruss P. RT Molecular basis of splotch and Waardenburg Pax-3 mutations RL Proc. Natl. Acad. Sci. USA 91:3685-3689 (1994). RN [4] RA Chalepakis G., Wijnholds J., Gruss P. RT Pax-3 - DNA interaction: flexibility in the DNA binding RT and induction of DNA conformational changes by paired domains RL Nucleic Acids Res. 22:3131-3137 (1994). RN [5] RA Chalepakis G., Jones F. S., Edelman G. M., Gruss P. RT Pax-3 contains domains for transcription activation RT and transcription inhibition RL Proc. Natl. Acad. Sci. USA 91:12745-12749 (1994). RN [6] RA Epstein J. A., Lam P., Jepeal L., Maas R. L., Shapiro D. N. RT Pax3 inhibits myogenic differentiation of cultured myoblast cells RL J. Biol. Chem. 270:11719-11722 (1995). RN [7] RA Bober E., Franz T., Arnold H. H., Gruss P., Tremblay P. RT Pax-3 is required for the development of limb muscles: RT a possible role for the migration of dermomyotomal muscle progenitor cells RL Development 120:603-612 (1994). RN [8] RA Goulding M., Lumsden A., Paquette A. J. RT Regulation of Pax-3 expression in the dermomyotome RT and its role in muscle development RL Development 120:957-971 (1994). RN [9] RA Epstein D. J., Vekemans M., Gros P. RT Splotch (Sp2H), a mutation affecting development of RT the mouse neural tube, shows a deletion within the RT paired homeodomain of Pax-3 RL Cell 67:767-774 (1991). RN [10] RA Vogan K. J., Epstein D. J., Trasler D. G., Gros P. RT The splotch-delayed (Spd) mouse mutant carries a point RT mutation within the paired box of the Pax-3 gene RL Genomics 17:364-369 (1993). RN [11] RA Goulding M. D., Chalepakis G., Deutsch U., Erselius J. R., Gruss P. RT Pax-3, a novel murine DNA binding protein expressed RT during early neurogenesis RL EMBO J. 10:1135-1147 (1991). XX // AC T00681 XX ID T00681 XX DT 16.12.92 (created); ewi. DT 15.05.96 (updated); ewi. XX FA Pax-6 XX SY Sey; Small eye; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0018; paired-homeo; 3.2.1.0.3. XX SZ 422 AA; 46.7 kDa (cDNA) XX SQ MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRY SQ YETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV SQ SSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQ SQ EGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFAR SQ ERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIP SQ QPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPT SQ SPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPR SQ LQ XX SC SwissProt #P32117 XX FT 4 128 paired domain FT 210 269 homeo domain FT 279 419 proline-/serine-/threonine-rich region (69/141) XX FF mutations may cause Small eye (Sey) [3]; XX MX M00097; V$PAX6_01 XX DR EMBL: X82150; MMPAX6DNA(g). DR EMBL: X63963; MMPAX6PBP(r). DR SwissProt: P32117; PAX6_MOUSE. DR PIR: C41061; C41061. XX RN [1] RA Walther C., Guenet J. L., Simon D., Deutsch U., Jostes RA B., Goulding M. D., Plachov D., Balling R., Gruss P. RT Pax: a murine multigene family of paired box-containing genes RL Genomics 11:424-434 (1991). RN [2] RA Walther C., Gruss P. RT Pax-6, a murine paired box gene, is expressed in the developing CNS RL Development 113:1435-1449 (1991). RN [3] RA Hill R. E., Favor J., Hogan B. L. M., Ton C. C. T., RA Saunders G. F., Hanson I. M., Prosser J., Jordan T., RA Hastie N. D., van Heyningen V. RT Mouse Small eye results from mutations in a paired-like RT homeobox-containing gene RL Nature 354:522-525 (1991). XX // AC T00682 XX ID T00682 XX DT 16.12.92 (created); ewi. DT 15.05.96 (updated); ewi. XX FA Pax[zf-a] XX SY Pax-6 (mouse); XX OS zebra fish, Brachydanio rerio OC eukaryota; animalia; metazoa; chordata; vertebrata; OC osteichthyes; actinopterygii; cypriniformes; cyprinoidei; cyprinidae XX CL C0018; paired-homeo; 3.2.1.0.3. XX SZ 437 AA; 48.4 kDa (cDNA) XX SQ MPQKEYYNRATWESGVASMMQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCD SQ ISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVGKIAQYKRECPSIFAWE SQ IRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYEKLRMLNGQTGTWGTRPG SQ WYPGTSVPGQPNQDGCQQSDGGGENTNSISSNGEDSDETQMRLQLKRKLQRNRTSFTQEQ SQ IEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNS SQ SSHIPISSSFSTSVYQPIPQPTTPVSFTSGSMLGRSDTALTNTYSALPPMPSFTMANNLP SQ MQPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQAHMNSQSMAASGTTSTGLISPGVSVPV SQ QVPGSEPDMSQYWPRLQ XX SC SwissProt # XX FT 23 147 paired domain FT 229 288 homeo domain FT 298 434 proline-/serine-/threonine-rich region (64/137) XX CP embryonic forebrain, midbrain, neural tube [1], [2]; XX DR EMBL: X63183; BRPAX6(r). DR EMBL: X61389; BRPAXZFA(r). DR SwissProt: P26630; PAX6_BRARE. DR PIR: S18558; S18558. XX RN [1] RA Krauss S., Johansen T., Korzh V., Fjose A. RT Expression pattern of zebrafish pax genes suggests RT a role in early brain regionalization RL Nature 353:267-270 (1991). RN [2] RA Krauss St., Johansen T., Korzh V., Moens U., Ericson J. U., Fjose A. RT Zebrafish pax[zf-a]: a paired box-containing gene RT expressed in the neural tube RL EMBO J. 10:3609-3616 (1991). XX // AC T00683 XX ID T00683 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA PEBP2 XX SY PEA2; PEBP3; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO FLV-1 XX SZ 50-60 kDa; 30-35 kDa, 20-25 kDa (SDS) XX SF composed of one alpha- (30 kDa) and one beta-subunit (20 kDa) XX FF activator; FF dephosphorylated form = PEBP3 XX BS R02927; HS$FN_05; Quality: 6; human, Homo sapiens BS R01221; PA$PY_03; Quality: 6; Py, polyoma virus BS R01222; PA$PY_04; Quality: 6; Py, polyoma virus BS R01228; PA$PY_10; Quality: 6; Py, polyoma virus XX DR EMBL: D14636; MMPEBP2A1(r). DR EMBL: D14637; MMPEBP2A2(r). DR EMBL: D14569; MMPEBP2B(g). DR EMBL: D14572; MMPEBP2B1(r). DR EMBL: D14571; MMPEBP2B2(r). DR EMBL: D14570; MMPEBP2B3(r). XX RN [1] RA Ogawa E., Maruyama M., Kagoshima H., Inuzuka M., Lu RA J., Satake M., Shigesada K., Ito Y. RT PEBP2/PEA2 represents a family of transcription factors RT homologous to the products of the Drosophila runt RT gene and the human AML1 gene RL Proc. Natl. Acad. Sci. USA 90:6859-6863 (1993). RN [2] RA Piette J., Yaniv M. RT Two different factors bind to the alpha-domain of RT the polyoma virus enhancer, one of which also interacts RT with the SV40 and c-fos enhancers RL EMBO J. 6:1331-1337 (1987). RN [3] RA Kryszke M.-H., Piette J., Yaniv M. RT Induction of a factor that binds to the polyoma virus RT A enhancer on differentiation of embryonal carcinoma cells RL Nature 328:254-256 (1987). RN [4] RA Martin M. E., Piette J., Yaniv M., Tang W.-J., Folk W. R. RT Activator of the polyomavirus enhancer by a murine RT activator protein 1 (AP1) homolog and two contiguous proteins RL Proc. Natl. Acad. Sci. USA 85:5839-5843 (1988). XX // AC T00684 XX ID T00684 XX DT 15.10.92 (created); ewi. DT 21.05.97 (updated); ewi. XX FA PEA3 XX SY E1A-F; PEA-3; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0016; ETS; 3.5.2.0.4. XX SZ 555 AA; 60.8 kDa (cDNA), 63-70 kDa (SDS) XX SQ MTKSSNHNCLLRPENKPGLWGPGAQAASLRPSPATLVVSSPGHAEHPPAAPAQTPGPQVS SQ ASARGPGPVAGGSGRMERRMKGGYLDQRVPYTFCSKSPGNGSLGEALMVPQGKLMDPGSL SQ PPSDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTD SQ PALSCSRKPPLPYHHGEQCLYSRQIAIKSPAPGAPGQSPLQPFSRAEQQQSLLRASSSSQ SQ SHPGHGYLGEHSSVFQQPVDMCHSFTSPQGGGREPLPAPYQHQLSEPCPPYPQQNFKQEY SQ HDPLYEQAGQPASSQGGVSGHRYPGAGVVIKQERTDFAYDSDVPGCASMYLHPEGFSGPS SQ PGDGVMGYGYEKSLRPFPDDVCIVPKKFEGDIKQEGIGAFREGPPYQRRGALQLWQFLVA SQ LLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQ SQ KVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAYLPEL SQ TGPAPPFGHRGGYSY XX SC edited SwissProt #P28322 XX FT 407 492 ETS domain FT 410 511 DNA-binding domain [4]; FT 415 452 tryptophan cluster (W-X17-W-X18-W) XX SF (conflict: H-429 is missing in SwissProt #P28322) XX CP epidermis, brain; lower levels in lung, mammary gland, pancreas [4]; CN bone marrow, heart, kidney, liver, salivary gland, CN spleen, testis, thymus [4]; XX FF activator [4]; FF functional cooperation with PEA1/AP-1 in activation FF [2] and for polyoma virus replication [6]; FF serum-activated, target for several non-nuclear oncogenes FF (Src, Py-middle T, Ha-Ras, mos, raf; FF not:fos) [3]; FF down-regulated during RA-induced differentiation of FF embryonic cell lines [4]; XX BS R02153; ETS1$CONS; Quality: 2 BS R02095; MOUSE$UPA_01; Quality: 4; mouse, Mus musculus BS R01224; PA$PY_06; Quality: 4; Py, polyoma virus BS R02232; PEA3$CONS; Quality: 6 XX DR EMBL: X63190; MMPEA3(r). DR SwissProt: P28322; PEA3_MOUSE. DR PIR: S24061; S24061. DR Compel: C00086 XX RN [1] RA Gunther C. V., Nye J. A., Bryner R. S., Graves B. J. RT Sequence-specific DNA binding of the proto-oncoprotein RT ets-1 defines a transcriptional activator sequence RT within the long terminal repeat of the Moloney murine sarcoma virus RL Genes Dev. 4:667-679 (1990). RN [2] RA Martin M. E., Piette J., Yaniv M., Tang W.-J., Folk W. R. RT Activator of the polyomavirus enhancer by a murine RT activator protein 1 (AP1) homolog and two contiguous proteins RL Proc. Natl. Acad. Sci. USA 85:5839-5843 (1988). RN [3] RA Wasylyk C., Flores P., Gutman A., Wasylyk B. RT PEA3 is a nuclear target for transcription activation RT by non-nuclear oncogenes RL EMBO J. 8:3371-3378 (1989). RN [4] RA Xin J.-H., Cowie A., Lachance P., Hassell J. A. RT Molecular cloning and characterization of PEA3, a RT new member of the Ets oncogene family that is differentially RT expressed in mouse embryonic cells RL Genes Dev. 6:481-496 (1992). RN [5] RA Gutman A., Wasylyk B. RT The collagenase gene promoter contains a TPA and oncogene-responsive RT unit encompassing the PEA3 and AP-1 binding sites RL EMBO J. 9:2241-2246 (1990). RN [6] RA Rochford R., Davis C. T., Yoshimoto K., Villarreal L. P. RT Minimal subenhancer requirements for high-level polyomavirus RT DNA replication: A cell-specific synergy of PEA3 and PEA1 sites RL Mol. Cell. Biol. 10:4996-5001 (1990). RN [7] RA Wasylyk B., Wasylyk C., Flores P., Bregue A., Leprince D., Stehelin D. RT The c-ets proto-oncogenes encode transcription factors RT that cooperate with c-Fos and c-Jun for transcriptional activation RL Nature 346:191-193 (1990). RN [8] RA Rorth P., Nerlov C., Blasi F., Johnsen M. RT Transcription factor PEA3 participates in the induction RT of urokinase plasminogen activator transcription in RT murine keratinocytes stimulated with epidermal growth RT factor or phorbol-ester RL Nucleic Acids Res. 18:5009-5017 (1990). RN [9] RA Wasylyk B., Wasylyk C., Flores P., Begue A., Leprince D., Stehelin D. RT The c-ets proto-oncogenes encode transcription factors RT that cooperate with c-Fos and c-Jun for transcriptional activation RL Nature 346:191-193 (1990). XX // AC T00685 XX ID T00685 XX DT 15.10.92 (created); ewi. DT 21.05.97 (updated); ewi. XX FA PEA3 XX SY E1A-F; PEA-3; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 3.5.2.0.4. XX SZ >462 AA; >51.5 kDa (cDNA); 65 kDa (SDS) XX SQ PEMGDLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFH SQ SENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPA SQ PGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQGGGR SQ EPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQE SQ QTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIK SQ QEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWG SQ IQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKA SQ EFDRPVSEEDTVPLSHLDESPAYLPELAGPAQPFGPKGGYSY XX SC translated from EMBL #D12765 XX FT 407 492 ETS domain FT 415 452 tryptophan cluster (W-X17-W-X18-W) XX FF monomeric DNA-binding; FF serum-activated, target for several non-nuclear oncogenes FF (Src, Py-middle T, Ha-Ras, mos, raf; FF not:fos) [1]; XX BS R02153; ETS1$CONS; Quality: 6 BS R01640; HS$CFOS_15; Quality: 4; human, Homo sapiens BS R01639; HS$CLASE_02; Quality: 4; human, Homo sapiens BS R03058; HS$STROM_01; Quality: 4; human, Homo sapiens BS R01224; PA$PY_06; Quality: 4; Py, polyoma virus BS R02232; PEA3$CONS; Quality: 6 XX DR EMBL: D12765; HSE1AF(r). DR SwissProt: P43268; E1AF_HUMAN. XX RN [1] RA Wasylyk C., Flores P., Gutman A., Wasylyk B. RT PEA3 is a nuclear target for transcription activation RT by non-nuclear oncogenes RL EMBO J. 8:3371-3378 (1989). RN [2] RA Gutman A., Wasylyk B. RT The collagenase gene promoter contains a TPA and oncogene-responsive RT unit encompassing the PEA3 and AP-1 binding sites RL EMBO J. 9:2241-2246 (1990). RN [3] RA Higashino F., Yoshida K., Fujinaga A., Kamio K., Fujinaga K. RT Isolation of a cDNA encoding the adenovirus E1A enhancer RT binding protein: a new human member of the ets oncogene family RL Nucleic Acids Res. 21:547-553 (1993). RN [4] RA Wasylyk B., Wasylyk C., Flores P., Bregue A., Leprince D., Stehelin D. RT The c-ets proto-oncogenes encode transcription factors RT that cooperate with c-Fos and c-Jun for transcriptional activation RL Nature 346:191-193 (1990). RN [5] RA Wasylyk B., Wasylyk C., Flores P., Begue A., Leprince D., Stehelin D. RT The c-ets proto-oncogenes encode transcription factors RT that cooperate with c-Fos and c-Jun for transcriptional activation RL Nature 346:191-193 (1990). XX // AC T00686 XX ID T00686 XX DT 27.01.93 (created); hse. DT 12.12.94 (updated); ewi. XX FA PEA3 XX SY PEA-3; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R02153; ETS1$CONS; Quality: 1 BS R02232; PEA3$CONS; Quality: 6 XX RN [1] RA Wasylyk C., Flores P., Gutman A., Wasylyk B. RT PEA3 is a nuclear target for transcription activation RT by non-nuclear oncogenes RL EMBO J. 8:3371-3378 (1989). RN [2] RA Gutman A., Wasylyk B. RT The collagenase gene promoter contains a TPA and oncogene-responsive RT unit encompassing the PEA3 and AP-1 binding sites RL EMBO J. 9:2241-2246 (1990). RN [3] RA Wasylyk B., Wasylyk C., Flores P., Bregue A., Leprince D., Stehelin D. RT The c-ets proto-oncogenes encode transcription factors RT that cooperate with c-Fos and c-Jun for transcriptional activation RL Nature 346:191-193 (1990). XX // AC T00687 XX ID T00687 XX DT 15.10.92 (created); ewi. XX FA PEB1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01226; PA$PY_08; Quality: 6; Py, polyoma virus BS R01231; PA$PY_13; Quality: 6; Py, polyoma virus XX RN [1] RA Martin M. E., Piette J., Yaniv M., Tang W.-J., Folk W. R. RT Activator of the polyomavirus enhancer by a murine RT activator protein 1 (AP1) homolog and two contiguous proteins RL Proc. Natl. Acad. Sci. USA 85:5839-5843 (1988). RN [2] RA Piette J., Yaniv M. RT Molecular analysis of the interaction between an enhancer RT binding factor and its DNA target RL Nucleic Acids Res. 14:9595-9611 (1986). XX // AC T00688 XX ID T00688 XX DT 15.10.92 (created); ewi. XX FA Pep-1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01630; RAT$PEPCK_08; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Ip Y. T., Fournier R. E. K., Chalkley R. RT Extinction of Phosphoenolpyruvate Carboxykinase Gene RT Expression Is Associated with Loss of a Specific Chromatin-Binding RT Protein from a Far Upstream Domain RL Mol. Cell. Biol. 10:3782-3787 (1990). XX // AC T00689 XX ID T00689 XX DT 15.10.92 (created); ewi. DT 29.01.97 (updated); ewi. XX FA PHO2 XX SY BAS2; GRF10; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0006; homeo; 3.1.1.0.7. XX SZ 559 AA; 63.4 kDa (gene), 83 kDa (SDS) XX SQ MMEEFSYDHDFNTHFATDLDYLQHDQQQQQQQQHDQQHNQQQQPQPQPIQTQNLEHDHDQ SQ HTNDMSASSNASDSGPQRPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKN SQ VRIWFQNRRAKLRKKQHGSNKDTIPSSQSRDIANDYDRGSTDNNLVTTTSTSSIFHDEDL SQ TFFDRIPLNSNNNYYFFDICSITVGSWNRMKSGALQRRNFQSIKELRNLSPIKINNIMSN SQ ATDLMVLISKKNSEINYFFSAMANNTKILFRIFFPLSSVTNCSLTLETDDDIINSNNTSD SQ KNNSNTNNDDDNDDNSNEDNDNSSEDKRNAKDNFGELKLTVTRSPTFAVYFLNNAPDEDP SQ NLNNQWSICDDFSEGRQVNDAFVGGSNIPHTLKGLQKSLRFMNSLILDYKSSNEILPTIN SQ TAIPTAAVPQQNIAPPFLNTNSSATDSNPNTNLEDSLFFDHDLLSSSITNTNNGQGSNNG SQ RQASKDDTLNLLDTTVNSNNNHNANNEENHLAQEHLSNDADIVANPNDHLLSLPTDSELP SQ NTPDFLKNTNELTDEHRWI XX SC SwissProt #P07269 XX FT 9 61 histidine pattern FT 23 52 glutamine-rich region (19/30) FT 77 136 homeo domain XX SF the histidine-rich region has been suggested to fold SF into a zinc finger-liker structure, but is not required for DNA-binding [5]; SF cooperative DNA-binding with SWI5 (T00776) [2]; SF prolonged PHO2 half-life in the ternary complex, but SF no SWI5 interaction in the absence of DNA [2]; XX FF appears to regulate basal and induced transcription FF of histidine pathway genes [5], [1]; FF together with PHO4 (T00690), it activates genes of FF the phosphate metabolism and derepresses the PHO5 FF gene coding for repressible acid phosphatase [1]; FF may also be involved in regulation of life cycle controlling genes [5]; XX IN T00690; PHO4; yeast, Saccharomyces cerevisiae. XX BS R00652; Y$HIS4_09; Quality: 1; yeast, Saccharomyces cerevisiae BS R00653; Y$HIS4_10; Quality: 1; yeast, Saccharomyces cerevisiae BS R03860; Y$HO_08; Quality: 2; yeast, Saccharomyces cerevisiae BS R03861; Y$HO_09; Quality: 2; yeast, Saccharomyces cerevisiae BS R01208; Y$PHO5_02; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: X05062; SCPHO2(g). DR EMBL: M22259; SCPHO201(g). DR SwissProt: P07269; PHO2_YEAST. DR PIR: A25872; A25872. XX RN [1] RA Vogel K., Hoerz W., Hinnen A. RT The Two Positively Acting Regulatory Proteins PHO2 RT and PHO4 Physically Interact with PHO5 Upstream Activation Regions RL Mol. Cell. Biol. 9:2050-2057 (1989). RN [2] RA Brazas R. M., Stillman D. J. RT The Swi5 zinc-finger and Grf10 homeodomain proteins RT bind DNA cooperatively at the yeast HO promoter RL Proc. Natl. Acad. Sci. USA 90:11237-11241 (1993). RN [3] RA Brazas R. M., Stillman D. J. RT Identification and purification of a protein that RT binds DNA cooperatively with yeast SWI5 protein RL Mol. Cell. Biol. 13:5524-5537 (1993). RN [4] RA Hirst K., Fisher F., McAndrew P. C., Goding C. R. RT The transcription factor, the Cdk, its cyclin and RT their regulator: directing the transcriptional response RT to a nutritional signal RL EMBO J. 13:5410-5420 (1994). RN [5] RA Berben G., Legrain M., Hilger F. RT Studies on structure, expression and function of the RT yeast regulatory gene PHO2 RL Gene 66:307-312 (1988). RN [6] RA Sengstag C., Hinnen A. RT The sequence of the Saccharomyces cerevisiae gene RT PHO2 codes for a regulatory protein with unusual amino acid composition RL Nucleic Acids Res. 15:233-246 (1987). RN [7] RA Arndt K. T., Styles C., Fink G. R. RT Multiple global regulators control HIS4 transcription in yeast RL Science 237:874-880 (1987). RN [8] RA Buerglin T. R. RT The yeast regulatory gene PHO2 encodes a Homeo Box RL Cell 53:339-340 (1988). RN [9] RA Tice-Baldwin K., Fink G. R., Arndt K. T. RT BAS1 Has a Myb Motif and Activates HIS4 Transcription RT Only in Combination with BAS2 RL Science 246:931-935 (1989). XX // AC T00690 XX ID T00690 XX DT 15.10.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA PHO4 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0010; bHLH; 1.2.5.3.1. XX SZ 312 AA; 34.1 kDa (gene) XX SQ MGRTTSEGIHGFVDDLEPKSSILDKVGDFITVNTKRHDGREDFNEQNDELNSQENHNSSE SQ NGNENENEQDSLALDDLDRAFELVEGMDMDWMMPSHAHHSPATTATIKPRLLYSPLIHTQ SQ SAVPVTISPNLVATATSTTSANKVTKNKSNSSPYLNKRRGKPGPDSATSLFELPDSVIPT SQ PKPKPKPKQYPKVILPSNSTRRVSPVTAKTSSSAEGVVVASESPVIAPHGSSHSRSLSKR SQ RSSGALVDDDKRESHKHAEQARRNRLAVPLHELASLIPAEWKQQNVSAAPSKATTVEAAC SQ RYIRHLQQNGST XX SC SwissProt #P07270 XX FT 1 31 repressing domain 1 (RD1), interacting with PHO80 [4]; FT 9 30 unusual leucine zipper (ILLI) FT 41 90 acidic region (18/50) FT 156 200 repressing domain 2 (RD2), interacting with PHO80 [6], [4]; FT 251 262 basic region FT 263 307 helix-loop-helix domain FT 200 218 PHO2-interacting region (PIS) [4]; FT 181 192 Pro-Lys repeats (5) XX SF DNA-binding specificity is dictated by five residues SF within the basic domain (D250, E253, H257, A258, E259) [2]; SF basic region can be replaced with that of c-Myc [8]; SF different C-terminus from position 290 has been reported [3]; SF PHO80 masks the trans-activating and the PHO2-contact domains of PHO4 [4]; XX FF activator; FF required for PHO8 expression, negatively controlled FF by PHO80, PHO81 and PHO85 in the presence of phosphate [4]; FF PHO81 facilitates PHO4 release under low phosphate concentrations [4]; FF subsequently, PHO4 can interact and cooperate with FF the homeo domain factor PHO2 [4]; FF a T residue 5' to the CANNTG consensus inhibits DNA binding [2]; XX IN T00689; PHO2; yeast, Saccharomyces cerevisiae. IN T01641; PHO80; yeast, Saccharomyces cerevisiae. XX MX M00064; F$PHO4_01 XX BS R01207; Y$PHO5_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01209; Y$PHO5_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R02975; Y$PHO8_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R03837; Y$PHO8_02; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: X03719; SCPHO4(g). DR SwissProt: P07270; PHO4_YEAST. DR PIR: A23482; A23482. XX RN [1] RA Vogel K., Hoerz W., Hinnen A. RT The Two Positively Acting Regulatory Proteins PHO2 RT and PHO4 Physically Interact with PHO5 Upstream Activation Regions RL Mol. Cell. Biol. 9:2050-2057 (1989). RN [2] RA Fisher F., Goding C. R. RT Single amino acid substitutions alter helix--loop--helix RT protein specificity for bases flanking the core CANNTG motif RL EMBO J. 11:4103-4109 (1992). RN [3] RA Legrain M., De Wilde M., Hilger F. RT Isolation, physical characterization and expression RT analysis of the Saccharomyces cerevisiae positive regulatory gene PHO4 RL Nucleic Acids Res. 14:3059-3073 (1986). RN [4] RA Hirst K., Fisher F., McAndrew P. C., Goding C. R. RT The transcription factor, the Cdk, its cyclin and RT their regulator: directing the transcriptional response RT to a nutritional signal RL EMBO J. 13:5410-5420 (1994). RN [5] RA Yoshida K., Kuromitsu Z., Ogawa N., Oshima Y. RT x RL Mol. Gen. Genet. 217:31-39 (1989). RN [6] RA Ogawa N., Oshima Y. RT Functional Domains of a Positive Regulatory Protein, RT PHO4, for Transcriptional Control of the Phosphatase RT Regulon in Saccharomyces cerevisiae RL Mol. Cell. Biol. 10:2224-2236 (1990). RN [7] RA Hayashi N., Oshima Y. RT Specific cis-acting sequence for PHO8 expression interacts RT with PHO4 protein, a positive regulatory factor, in Saccharomyces cerevisiae RL Mol. Cell. Biol. 11:785-794 (1991). RN [8] RA Fisher F., Jayaraman P.-S., Goding C. R. RT c-Myc and the yeast transcription factor PHO4 share RT a common CACGTG-binding motif RL Oncogene 6:1099-1104 (1991). XX // AC T00691 XX ID T00691 XX DT 15.10.92 (created); ewi. DT 13.08.96 (updated); ewi. XX FA Pit-1a XX SY GHF-2; LSF-1; PUF-1; PUF-I; Pit-1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.2.1.1.1. XX SZ 317 AA; 35.8 kDa (cDNA), 43 kDa (SDS) [28]; XX SQ MSCQPFTSADTFIPLNSDASAALPLRMHHSAAEGLPASNHATNVMSTVPSILSLIQTPKC SQ LHTYFSMTTMGNTATGLHYSVPSCHYGNQPSTYGVMAGTLTPCLYKFPDHTLSHGFPPLH SQ QPLLAEDPTASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVG SQ EALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERK SQ RKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKT SQ SLNQSLFSISKEHLECR XX SC SwissProt #P10037 XX FT 2 83 serine-/threonine-rich region (22/82) FT 48 73 missing in Pit-1b/GHF-1 FT 151 224 POU-specific domain FT 240 299 POU homeo domain FT 10 40 major trans-activation domain [9]; XX SF alternative splicing gives rise to a 291 AA protein which is the major form SF Pit-1a makes approximately 1/7 of all Pit-1 mRNA in SF pituitary cells [11], [7]; SF alternative translation initiation gives rise to another SF product of 31 kDa [15]; SF both POUs and POUh contact DNA [9]; SF POUh domain is sufficient for DNA-binding, POUs and SF the linker region between POUs and POUh augment in SF enhancing affinity and specificity [26], [9], [10]; SF POUs induces bending of the DNA [1]; SF free in solution: Pit-1 monomers or Pit-1/Oct-1 heterodimers, SF homodimers form upon DNA-binding [9], [18]; XX CP lactotrophs, somatotrophs and thyrotrophs of anterior CP pituitary gland [28], [23], [8]; CN gonadotrophs of anterior pituitary gland, posterior CN pituitary, heart, hypothalamus, kidney, liver, prostate, CN testis, thyroid [28], [23], [8]; XX FF tissue-specific activator [28], [26]; FF although binding to Pit-1 sites like Pit-1b, it trans-activates FF the growth hormone (GH) gene, but not the Prl and FF GHF1 promoters (in contrast to GHF-1) due to the 26 AA insertion [7]; FF transcription of the pit-1 gene is triggered by environmental FF stimuli that enhance intracellular cAMP concentrations [14]; FF autoregulation through several promoter and enhancer FF elements [13], [14], [20]; FF may also be regulated through a potent vitamin D3 responsive element [20]; FF may be subject of differential cell-type specific translational control [8]; FF activity at the GH promoter is counteracted by activin [6]; XX BS R02160; GHF1$CONS; Quality: 6 BS R03190; HS$CS1_02; Quality: 6; human, Homo sapiens BS R03191; HS$CS1_03; Quality: 6; human, Homo sapiens BS R03955; HS$CSB_01; Quality: 5; human, Homo sapiens BS R00609; HS$GRH_03; Quality: 6; human, Homo sapiens BS R00611; HS$GRH_05; Quality: 6; human, Homo sapiens BS R00612; HS$GRH_06; Quality: 6; human, Homo sapiens BS R02783; HS$PL_01; Quality: 6; human, Homo sapiens BS R02784; HS$PL_02; Quality: 6; human, Homo sapiens BS R02786; HS$PL_04; Quality: 6; human, Homo sapiens BS R02787; HS$PL_05; Quality: 6; human, Homo sapiens BS R02789; HS$PL_07; Quality: 6; human, Homo sapiens BS R02790; HS$PL_08; Quality: 6; human, Homo sapiens BS R02791; HS$PL_09; Quality: 6; human, Homo sapiens BS R02792; HS$PL_10; Quality: 6; human, Homo sapiens BS R03481; HS$PL_11; Quality: 6; human, Homo sapiens BS R03483; HS$PL_13; Quality: 6; human, Homo sapiens BS R00622; RAT$GRH_16; Quality: 6; rat, Rattus norvegicus BS R00623; RAT$GRH_17; Quality: 6; rat, Rattus norvegicus BS R01263; RAT$PL_02; Quality: 6; rat, Rattus norvegicus BS R01264; RAT$PL_03; Quality: 6; rat, Rattus norvegicus BS R01265; RAT$PL_04; Quality: 6; rat, Rattus norvegicus BS R01266; RAT$PL_05; Quality: 6; rat, Rattus norvegicus BS R01270; RAT$PL_09; Quality: 6; rat, Rattus norvegicus BS R01273; RAT$PL_12; Quality: 6; rat, Rattus norvegicus BS R01276; RAT$PL_15; Quality: 6; rat, Rattus norvegicus BS R01280; RAT$PL_19; Quality: 6; rat, Rattus norvegicus XX DR EMBL: X65364; RNGHF11(g). DR EMBL: X65365; RNGHF12(g). DR EMBL: X65367; RNGHF13(g). DR EMBL: X65368; RNGHF15(g). DR EMBL: X63089; RRPITEX1A(g). DR SwissProt: P10037; HMP1_RAT. DR PIR: S22705; S22705. DR Compel: C00047 DR Compel: C00131 DR Compel: C00137 DR Compel: C00138 XX RN [1] RA Verrijzer C. P., van Oosterhout J. A. W. M., van Weperen RA W. W., van der Vliet P. C. RT POU proteins bend DNA via the POU-specific domain RL EMBO J. 10:3007-3014 (1991). RN [2] RA Cao Z., Barron E. A., Carillo A. J., Sharp Z. D. RT Reconstitution of Cell-Type-Specific Transcription RT of the Rat Prolactin Gene In Vitro RL Mol. Cell. Biol. 7:3402-3408 (1987). RN [3] RA Cao Z., Barron E. A., Sharp Z. D. RT Prolactin Upstream Factor I Mediates Cell-Specific Transcription RL Mol. Cell. Biol. 8:5432-5438 (1988). RN [4] RA Sharp Z. D., Helsel S., Cao Z., Barron E. A., Sanchez Y. RT DNA recognition element required for PUF-I mediated RT cell-type specific transcription of the rat prolactin gene RL Nucleic Acids Res. 17:2705-2722 (1989). RN [5] RA Elsholtz H. P., Albert V. R., Treacy M. N., Rosenfeld M. G. RT A two-base change in a POU factor-binding site switches RT pituitary-specific to lymphoid-specific gene expression RL Genes Dev. 4:43-51 (1990). RN [6] RA Struthers R. S., Gaddy-Kurten D., Vale W. W. RT Activin inhibits binding of transcription factor Pit-1 RT to the growth hormone promoter RL Proc. Natl. Acad. Sci. USA 89:11451-11455 (1992). RN [7] RA Theill L. E., Hattori K., Lazzaro D., Castrillo J.-L., Karin M. RT Differential splicing of the GHF1 primary transcript RT gives rise to two functionally distinct homeodomain proteins RL EMBO J. 11:2261-2269 (1992). RN [8] RA Simmons D.M., Voss J.W., Ingraham H.A., Holloway J.M., RA Broide R.S., Rosenfeld M.G., Swanson L.W. RT Pituitary cell phenotypes involve cell-specific Pit-1 RT mRNA translation and synergistic interactions with RT other classes of transcription factors RL Genes Dev. 4:695-711 (1990). RN [9] RA Ingraham H. A., Flynn S. E., Voss J. W., Albert V. RA R., Kapiloff M. S., Wilson L., Rosenfeld M. G. RT The POU-specific domain of Pit-1 is essential for RT sequence-specific, high affinity DNA binding and DNA-dependent RT Pit-1-Pit-1 interactions RL Cell 61:1021-1033 (1990). RN [10] RA Aurora R., Herr W. RT Segments of the POU domain influence one another's DNA-binding specificity RL Mol. Cell. Biol. 12:455-467 (1992). RN [11] RA Morris A. E., Kloss B., McCesney R. E., Bancroft C., Chasin L. A. RT An alternatively spliced Pit-1 isoform altered in RT its ability to trans-activate RL Nucleic Acids Res. 20:1355-1361 (1992). RN [12] RA Howard P. W., Maurer R. A. RT A composite Ets/Pit-1 binding site in the prolactin RT gene can mediate transcriptional response to multiple RT signal transduction pathways RL J. Biochem. 270:20930-20936 (1995). RN [13] RA Chen R., Ingraham H. A., Treacy M. N., Albert V. R., RA Wilson L., Rosenfeld M. G. RT Autoregulation of pit-1 gene expression mediated by RT two cis-active promoter elements RL Nature 346:583-586 (1990). RN [14] RA McCormick A., Brady H., Theill L. E., Karin M. RT Regulation of the pituitary-specific homeobox gene RT GHF1 by cell-autonomous and environmental cues RL Nature 345:829-832 (1990). RN [15] RA Voss J. W., Yao T.-P., Rosenfeld M. G. RT Alternative translation initiation site usage results RT in two structurally distinct forms of Pit-1 RL J. Biol. Chem. 266:12832-12835 (1991). RN [16] RA Kapiloff M. S., Farkash Y., Wegner M., Rosenfeld M. G. RT Variable effects of phosphorylation of Pit-1 dictated RT by the DNA response elements RL Science 253:789-789 (1991). RN [17] RA Hoggard N., Davis J. R. E., Berwaer M., Monget P., RA Peers B., Belayew A., Martial J. A. RT Pit-1 binding sequences permit calcium regulation RT of human prolactin gene expression RL Mol. Endocrinol. 5:1748-1754 (1991). RN [18] RA Voss J. W., Wilson L., Rosenfeld M. G. RT POU-domain proteins Pit-1 and Oct-1 interact to form RT a heteromeric complex and can cooperate to induce RT expression of the prolactin promoter RL Genes Dev. 5:1309-1320 (1991). RN [19] RA Steinfelder H. J., Wondisford F. E., Radovick S. RT Hormonal regulation of the thyrotropin b-subunit gene RT by phosphorylation of the pituitary-specific transcription factor PIT-1 RL Proc. Natl. Acad. Sci. USA 89:5942-5945 (1992). RN [20] RA Rhodes S. J., Chen R., DiMattia G. E., Scully K. M., RA Kalla K. A., Lin S.-C., Yu V. C., Rosenfeld M. G. RT A tissue-specific enhancer confers Pit-1-dependent RT morphogen inducibility and autoregulation on the pit-1 gene RL Genes Dev. 7:913-932 (1993). RN [21] RA Lew A. M., Yao H., Elsholtz H. P. RT Gia2- and G0a-mediated signaling in the Pit-1-dependent RT inhibition of the prolactin gene promoter RL J. Biol. Chem. 269:12007-12013 (1994). RN [22] RA Yan G. Z., Bancroft C. RT Mediation by calcium of thyrotropin--releasing hormone RT action on the prolactin promoter via transcription factor pit-1 RL Mol. Endocrinol. 5:1488-1497 (1991). RN [23] RA Mangalam H. J., Albert V. R., Ingraham H. A., Kapiloff RA M., Wilson L., Nelson Ch., Elsholtz H., Rosenfeld M. G. RT A pituitary POU domain protein, Pit-1, activates both RT growth hormone and prolactin promoters transcriptionally RL Genes Dev. 3:946-958 (1989). RN [24] RA Lefevre C., Imagawa M., Dana S., Grindlay J., Bodner M., Karin M. RT Tissue-specific expression of the human growth hormone RT gene is conferred in part by the binding of a specific trans-acting factor RL EMBO J. 6:971-981 (1987). RN [25] RA Bodner M., Karin M. RT A Pituitary-Specific Trans-Acting Factor Can Stimulate RT Transcription from the Growth Hormone Promoter in RT Extracts of Nonexpressing Cells RL Cell 50:267-275 (1987). RN [26] RA Theill L. E., Castrillo J.-L., Wu D., Karin M. RT Dissection of functional domains of the pituitary-specific RT transcription factor GHF-1 RL Nature 342:945-948 (1989). RN [27] RA Nelson C., Albert V. R., Elsholtz H. P., Lu L. I.-W., Rosenfeld M. G. RT Activation of cell-specific expression of rat growth RT hormone and prolactin genes by a common transcription factor RL Science 239:1400-1405 (1988). RN [28] RA Ingraham H. A., Chen R., Mangalam H. J., Elsholtz RA H. P., Flynn S. E., Lin C. R., Simmons D. M., Swanson L., Rosenfeld M. G. RT A tissue-specific transcription factor containing RT a homeodomain specifies a pituitary phenotype RL Cell 55:519-529 (1988). RN [29] RA Steinfelder H. J., Hauser P., Nakayama Y., Radovick RA S., McClaskey J. H., Taylor T., Weintraub B. D., Wondisford F. E. RT Thyrotropin-releasing hormone regulation of human RT TSHB expression: Role of a pituitary-specific transcription RT factor (Pit-1/GHF-1) and potential interaction with RT a thyroid hormone-inhibitory element RL Proc. Natl. Acad. Sci. USA 88:3130-3134 (1991). RN [30] RA Castrillo J.-L., Bodner M., Karin M. RT Purification of growth hormone-specific transcription RT factor GHF-1 containing homeobox RL Science 243:814-817 (1989). RN [31] RA Schaufele F., West B. L., Reudelhuber T. RT Somatotroph- and lactotroph-specific interactions RT with the homeobox protein binding sites in the rat RT growth hormone gene promoter RL Nucleic Acids Res. 18:5235-5244 (1990). XX // AC T00692 XX ID T00692 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA PO-B XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 54, 56 kDa (SDS) XX SF highly hydrophobic, heat and acid stable XX FF dephosphorylation increases DNA-binding XX BS R02018; RAT$POMC_06; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Wellstein A., Dobrenski A. F., Radonovich M. N., Brady J. F., Riegel A. T. RT Purification of PO-B, a protein that has increased RT affinity for the pro-opiomelanocortin gene promoter after dephosphorylation RL J. Biol. Chem. 266:12234-12241 (1991). RN [2] RA Riegel A. T., Remenick J., Wolford R. G., Berard D. S., Hager G. L. RT An novel transcriptional activator (PO-B) binds between RT the TATA box and cap site of the pro-opiomelanocortin gene RL Nucleic Acids Res. 18:4513-4521 (1990). XX // AC T00693 XX ID T00693 XX DT 15.12.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Pc XX SY Polycomb; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0006; homeo; . XX SQ MTGRGKGSKGKLGRDNATDDPVDLVYAAEKIIQKRVKKGVVEYRVKWKGWNQRYNTWEPE SQ VNILDRRLIDIYEQTNKSSGTPSKRGIKKKEKEPDPEPESEEDEYTFTENDVDTHQATTS SQ SATHDKESKKEKKHHHHHHHHHHIKSERNSGRRSESPLTHHHHHHHHESKRQRIDHSSSS SQ NSSFTHNSFVPEPDSNSSSSEDQPLIGTKRKAEVLKESGKIGVTIKTSPDGPTIKPQPTQ SQ QVTPSQQQPFQDQQQAEKIASEAATQLKSEQQATPLATEAINTTPAESGAEEEEVANEEG SQ NQQAPQVPSENNNIPKPCNNLAINQKQPLTPLSPRALPPRFWLPAKCNISNRVVITDVTV SQ NLETVTIRECKTERGFFRERDMKGDSSPVA XX SC SwissProt #P26017 XX FF repressor; FF binds to at least 60 discrete sites along the polytene FF chromosomes of salivary glands XX DR EMBL: X55702; DMPCGENE(g). DR SwissProt: P26017; PC_DROME. DR PIR: A38565; A38565. DR Flybase: FBgn0003042; Pc. XX RN [1] RA Zink B., Paro R. RT In vivo binding pattern of a trans-regulator of homeotic RT genes in Drosophila melanogaster RL Nature 337:468 (1989). XX // AC T00694 XX ID T00694 XX DT 27.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA PPAR XX SY PPARalpha; peroxisome proliferator-activated receptor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.2.7. XX SZ 468 AA; 52.4 kDa (cDNA) XX SQ MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSC SQ PGSEGSVITDTLSPRSSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACE SQ GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE SQ KAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFV SQ IHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANL SQ DLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFD SQ FAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDT SQ FLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY XX SC SwissProt #P23204 XX FT 1 101 region A/B FT 102 166 region C FT 167 244 region D FT 245 468 region E/F XX SF requires heterodimerization with RXR (RXRalpha) for DNA-binding SF binds to direct repeat elements with 1bp spacing (DR1) [2]; XX CP liver, kidney, heart, brown adipose tissue cells XX FF member of the steroid hormone receptor superfamily; FF control of peroxisomal beta-oxidation pathway XX IN T01331; RXR-alpha; mouse, Mus musculus. IN T01345; RXR-alpha; human, Homo sapiens. IN T01359; RXR-alpha; clawed frog, Xenopus laevis. XX MX M00242; V$PPARA_01 XX BS R02233; PPAR$CONS; Quality: 6 XX DR EMBL: X57638; MMPPAR(r). DR SwissProt: P23204; PPAR_MOUSE. DR PIR: S11659; S11659. XX RN [1] RA Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W. RT Control of the peroxisomal beta-oxidation pathway RT by a novel family of nuclear hormone receptors RL Cell 68:879-887 (1992). RN [2] RA Palmer C. N. A., Hsu M.-H., Griffin K. J., Johnson E. F. RT Novel sequence determinants in peroxisome proliferator signaling RL J. Biol. Chem. 270:16114-16121 (1995). RN [3] RA Issenmann I., Green S. RT Activation of a member of the steroid hormone receptor RT superfamily by peroxisome proliferators RL Nature 247:645-650 (1990). XX // AC T00695 XX ID T00695 XX DT 20.11.92 (created); ewi. XX FA PPR1-dependent protein XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX BS R02407; Y$URA3_01; Quality: 2; yeast, Saccharomyces cerevisiae XX RN [1] RA Roy A., Exinger F., Losson R. RT cis- and trans-acting regulatory elements of the yeast URA3 promoter RL Mol. Cell. Biol. 10:5257-5270 (1990). XX // AC T00696 XX ID T00696 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA PR XX SY PR B; progesterone receptor; progesterone receptor form B; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); 2.1.1.2.1. XX SZ 933 AA; 99.0 kDa (cDNA), 114-120 kDa (SDS) XX SQ MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF SQ PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA SQ PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA SQ AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDSSESEESAGPLLKGK SQ PRALGGAAAGGGAAACPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV SQ MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRTSPCASSTPVAVGDFPD SQ CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG SQ PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC SQ KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP SQ YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN SQ YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPL SQ GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ SQ LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP SQ DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ SQ FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA SQ LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK XX SC SwissProt #P06401 XX FT 1 555 region A/B FT 1 164 missing in form A FT 456 546 transcription activation function (TAF 1) [3], [7]; FT 556 641 region C, DNA-binding domain (DBD) FT 642 686 region D FT 687 933 hormone-binding domain (HBD), transcription FT activation function (TAF 2) [3], [7]; XX SF alternative promoter usage and, concomitantly, alternative SF translation initiation gives rise to isoform A [9]; SF dimerization and nuclear translocation is inhibited by hsp90 [8]; XX FF activator or repressor in response to progesterone; FF both PR isoforms exhibit different promoter specificity [9]; XX IN T00696; PR; human, Homo sapiens. IN T00992; Hsp90; human, Homo sapiens. IN T01661; PR A; human, Homo sapiens. XX BS R00973; CHICK$LYS_01; Quality: 1; chick, Gallus gallus BS R00974; CHICK$LYS_02; Quality: 1; chick, Gallus gallus BS R00975; CHICK$LYS_03; Quality: 1; chick, Gallus gallus BS R00976; CHICK$LYS_04; Quality: 1; chick, Gallus gallus BS R00978; CHICK$LYS_06; Quality: 1; chick, Gallus gallus BS R02234; PR$CONS; Quality: 2 XX DR EMBL: M15716; HSPGRR(r). DR EMBL: X51730; HSPREC(r). DR SwissProt: P06401; PRGR_HUMAN. DR PIR: A03245; QRHUP. DR PIR: S09971; S09971. XX RN [1] RA Hecht A., Berkenstam A., Stroemstedt P.-E., Gustafsson J.-A., Sippel A. E. RT A progesterone responsive element maps to the far RT upstream steroid DNase hypersensitive site of chicken lysozyme chromatin RL EMBO J. 7:2063-2073 (1988). RN [2] RA Evans R. M. RT The steroid and thyroid hormone receptor superfamily RL Science 240:889-895 (1988). RN [3] RA Meyer M.-E., Quirin-Stricker C., Lerouge T., Bocqel M.-T., Gronemeyer H. RT A limiting factor mediates the differential activation RT of promoters by the human progesterone receptor isoforms RL J. Biol. Chem. 267:10882-10887 (1992). RN [4] RA Rehberger P., Rexin M., Gehring U. RT Heterotetrameric structure of the human progesterone receptor RL Proc. Natl. Acad. Sci. USA 89:8001-8005 (1992). RN [5] RA Edwards D. P., Estes P. A., Fadok V. A., Bona B. J., RA Onate S., Nordeen S. K., Welch W. J. RT Heat shock alters the composition of the heteromeric RT steroid receptor complexes and enhances receptor activity in vivo RL Biochemistry 31:2482-2491 (1992). RN [6] RA Misrahi M., Atger M., d'Auriol L., Loosfelt H., Meriel RA C., Fridlansky F., Guichon-Mantel A., Galibert F., Milgrom E. RT Complete amino acid sequence of the human progesterone RT receptor deduced from cloned cDNA. Biochem RL Biochem. Biophys. Res. Commun. 143:740-748 (1987). RN [7] RA Shemshedini L., Ji J., Brou C., Chambon P., Gronemeyer H. RT In vivo acticity of the transcription activation functions RT of the progesterone receptor RL J. Biol. Chem. 267:1834-1839 (1992). RN [8] RA DeMarzo A. M., Beck C. A., Onate S. A., Edwards D. P. RT Dimerization of mammalian progesterone receptors occurs RT in the absence of DNA and is related to the release RT of the 90-kDa heat shock protein RL Proc. Natl. Acad. Sci. USA 88:72-76 (1991). RN [9] RA Kastner P., Krust A., Turcotte B., Stropp U., Tora RA L., Gronemeyer H., Chambon P. RT Two distinct estrogen-regulated promoters generate RT transcripts encoding the two functionally different RT human progesterone receptor forms A and B RL EMBO J. 9:1603-1614 (1990). RN [10] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). XX // AC T00697 XX ID T00697 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA PR XX SY progesterone receptor; XX OS rabbit, Oryctolagus cuniculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; lagomorpha; leporidae XX CL C0002; CC (rec); 2.1.1.2.1. XX SZ 930 AA; 98.7 kDa (cDNA), 110 kDa (SDS) [8]; XX SQ MTELKAKEPRAPHVAGGAPSPTEVGSQLLGRPDPGPFQGSQTSEASSVVSAIPISLDGLL SQ FPRPCQGQNPPDGKTQDPPSLSDVEGAFPGVEAPEGAGDSSSRPPEKDSGLLDSVLDTLL SQ APSGPGQSHASPATCEAISPWCLFGPDLPEDPRAAPATKGVLAPLMSRPEDKAGDSSGTA SQ AAHKVLPRGLSPSRQLLLPSSGSPHWPAVKPSPQPAAVQVDEEDSSESEGTVGPLLKGQP SQ RALGGTAAGGGAAPVASGAAAGGVALVPKEDSRFSAPRVSLAEQDAPVAPGRSPLATSVV SQ DFIHVPILPLNHAFLATRTRQLLEGESYDGGAAAASPFVPQRGSPSASSTPVAGGDFPDC SQ TYPPDAEPKDDAFPLYGDFQPPALKIKEEEEAAEAAARSPRTYLVAGANPAAFPDFQLAA SQ PPPPSLPPRVPSSRPGEAAVAASPGSASVSSSSSSGSTLECILYKAEGAPPQQGPFAPLP SQ CKPPGAGACLLPRDGLPSTSASGAAAGAAPALYPTLGLNGLPQLGYQAAVLKEGLPQVYT SQ PYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQH SQ NYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRALDAVALPQP SQ VGIPNESQRITFSPSQEIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE SQ RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI SQ LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQSQFEE SQ MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV SQ EFPEMMSEVIAAQLPKILAGMVKPLLFHKK XX SC SwissProt #P06186 XX FT 1 556 region A/B FT 557 642 region C, DNA-binding domain (DBD) FT 643 683 region D FT 684 930 region E, hormone-binding domain (HBD) XX SF 3 different nuclear localization signals within second SF zinc finger, at the C/D region border, and a weak SF hormone-inducible one within the HBD [8]; XX CP (uterus) XX IN T00697; PR; rabbit, Oryctolagus cuniculus. XX BS R03525; AS$PR_01; Quality: 6 BS R03559; AS$PR_02; Quality: 2 BS R03560; AS$PR_03; Quality: 2 BS R00983; CHICK$LYS_11; Quality: 2; chick, Gallus gallus BS R00985; CHICK$LYS_13; Quality: 2; chick, Gallus gallus BS R01575; CHICK$VIT2_08; Quality: 1; chick, Gallus gallus BS R01102; MMTV$MMTV_04; Quality: 2; MMTV, mouse mammary tumor virus BS R01104; MMTV$MMTV_06; Quality: 1; MMTV, mouse mammary tumor virus BS R01106; MMTV$MMTV_08; Quality: 6; MMTV, mouse mammary tumor virus BS R01107; MMTV$MMTV_09; Quality: 6; MMTV, mouse mammary tumor virus BS R01108; MMTV$MMTV_10; Quality: 6; MMTV, mouse mammary tumor virus BS R01112; MMTV$MMTV_14; Quality: 2; MMTV, mouse mammary tumor virus BS R01117; MMTV$MMTV_19; Quality: 2; MMTV, mouse mammary tumor virus BS R01118; MMTV$MMTV_20; Quality: 2; MMTV, mouse mammary tumor virus BS R01120; MMTV$MMTV_22; Quality: 1; MMTV, mouse mammary tumor virus BS R01123; MMTV$MMTV_25; Quality: 1; MMTV, mouse mammary tumor virus BS R01124; MMTV$MMTV_26; Quality: 1; MMTV, mouse mammary tumor virus BS R02234; PR$CONS; Quality: 6 BS R03270; RABBIT$PR_02; Quality: 1; rabbit, Oryctolagus cuniculus BS R03271; RABBIT$PR_03; Quality: 1; rabbit, Oryctolagus cuniculus BS R01546; RABBIT$UG_01; Quality: 2; rabbit, Oryctolagus cuniculus BS R01548; RABBIT$UG_03; Quality: 2; rabbit, Oryctolagus cuniculus BS R01551; RABBIT$UG_06; Quality: 2; rabbit, Oryctolagus cuniculus BS R01552; RABBIT$UG_07; Quality: 2; rabbit, Oryctolagus cuniculus BS R01553; RABBIT$UG_08; Quality: 2; rabbit, Oryctolagus cuniculus BS R01554; RABBIT$UG_09; Quality: 2; rabbit, Oryctolagus cuniculus BS R01555; RABBIT$UG_10; Quality: 2; rabbit, Oryctolagus cuniculus BS R01556; RABBIT$UG_11; Quality: 2; rabbit, Oryctolagus cuniculus XX DR EMBL: M14547; OCPGR(r). DR SwissProt: P06186; PRGR_RABIT. DR PIR: A25923; A25923. XX RN [1] RA von der Ahe D., Janich S., Scheidereit C., Renkawitz RA R., Schuetz G., Beato M. RT Glucocorticoid and progesterone receptors bind the RT same sites in two hormonally regulated promoters RL Nature 313:706-709 (1985). RN [2] RA Guiochon-Mantel A., Loosfelt H., Ragot T., Bailly RA A., Atger M., Misrahi M., Perricaudet M., Milgrom E. RT Receptors bound to antiprogestin form abortive complexes RT with hormone responsive elements RL Nature 336:695-698 (1988). RN [3] RA Schauer M., Chalepakis G., Willmann T., Beato M. RT Binding of hormone accelerates the kinetics of glucocorticoid RT and progesterone receptor binding to DNA RL Proc. Natl. Acad. Sci. USA 86:1123-1127 (1989). RN [4] RA Jantzen K., Fritton H. P., Igo-Kemenes T., Espel E., RA Janich S., Cato A. C. B., Mugele K., Beato M. RT Partial overlapping of binding sequences for steroid RT hormone receptors and DNaseI hypersensitive sites RT in the rabbit uteroglobin gene region RL Nucleic Acids Res. 15:4535-4552 (1987). RN [5] RA Bailly A., Le Page C., Rauch M., Milgrom E. RT Sequence-specific DNA binding of the progesterone RT receptor to the uteroglobin gene: effects of hormone, RT antihormone and receptor phosphorylation RL EMBO J. 5:3235-3241 (1986). RN [6] RA Cato A. C. B., Heitlinger E., Ponta H., Klein-Hitpass RA L., Ryffel G. U., Bailly A., Rauch C., Milgrom E. RT Estrogen and Progesterone Receptor-Binding Sites on RT the Chicken Vitellogenin II Gene: Synergism of Steroid Hormone Action RL Mol. Cell. Biol. 8:5323-5330 (1988). RN [7] RA Loosfelt H., Atger M., Misrahi M., Guiochon-Mantel RA A., Meriel C., Logeat F., Benarous R., Milgrom E. RT Cloning and sequence analysis of rabbit progesterone-receptor RT complementary DNA RL Proc. Natl. Acad. Sci. USA 83:9045-9049 (1986). RN [8] RA Guichon-Mantel A., Loosfelt H., Lescop P., Sar S., RA Atger M., Perrot-Applanat M., Milgrom E. RT Mechanisms of nuclear localization of the progesterone RT receptor: evidence for interaction between monomers RL Cell 57:1147-1154 (1989). RN [9] RA Brueggemeier U., Rogge L., Winnacker E.-L., Beato M. RT Nuclear factor I acts as a transcription factor on RT the MMTV promoter but competes with steroid hormone RT receptors for DNA binding RL EMBO J. 9:2233-2239 (1990). RN [10] RA Savouret J. F., Bailly A., Mirashi M., Rauch C., Redeuilh RA G., Chauchereau A., Milgrom E. RT Characterization of the hormone responsive element RT involved in the regulation of the progesterone receptor gene RL EMBO J. 10:1875-1883 (1991). XX // AC T00698 XX ID T00698 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA PR XX SY PR B; progesterone receptor; progesterone receptor form B; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0002; CC (rec); 2.1.1.2.1. XX SZ 786 AA; 85.7 kDa (cDNA), 108 kDa (SDS) XX SQ MTEVKSKETRAPSSARDGAVLLQAPPSRGEAEGIDVALDGLLYPRSSDEEEEEEENEEEE SQ EEEEPQQREEEEEEEEEDRDCPSYRPGGGSLSKDCLDSVLDTFLAPAAHAAPWSLFGPEV SQ PEVPVAPMSRGPEQKAVDAGPGAPGPSQPRPGAPLWPGADSLNVAVKARPGPEDASENRA SQ PGLPGAEERGFPERDAGPGEGGLAPAAAASPAAVEPGAGQDYLHVPILPLNSAFLASRTR SQ QLLDVEAAYDGSAFGPRSSPSVPAADLAEYGYPPPDGKEGPFAYGEFQSALKIKEEGVGL SQ PAAPPPFLGAKAAPADFAQPPRAGQEPSLECVLYKAEPPLLPGAYGPPAAPDSLPSTSAA SQ PPGLYSPLGLNGHHQALGFPAAVLKEGLPQLCPPYLGYVRPDTETSQSSQYSFESLPQKI SQ CLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRK SQ CCQAGMVLGGRKFKKLNKMKVVRTLDVALQQPAVLQDETQSLTQRLSFSPNQEIPFVPPM SQ ISVLRGIEPEVVYAGYDNTKPETPSSLLTSLNHLCERQLLCVVKWSKLLPGFRNLHIDDQ SQ ITLIQYSWMSLMVFAMGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLSMWQLPQE SQ FVRLQVSQEEFLCMKALLLLNTIPLEGLRSQSQFDEMRTSYIRELVKAIGLRQKGVVANS SQ QRFYQLTKLMDSMHDLVKQLHLFCLNTFLQSRALSVEFPEMMSEVIAAQLPKILAGMVKP SQ LLFHKK XX SC SwissProt #P07812 XX FT 1 409 region A/B FT 410 492 region C, DNA-binding domain (DBD) FT 493 634 region D FT 635 786 region E, hormone-binding domain (HBD) FT 1 127 missing in form A FT 477 487 NLS (region C) FT 491 505 NLS (region C/D) XX SF alternative translation initiation (-128 AA) leads to isoform A [18], [11]; SF 2nd zinc finger: NLS (nuclear localization signal) SF weak hormone-inducible NLS within hormone-binding domain [2]; XX FF activator or repressor in response to progesterone; FF isoforms A and B differentially activate the progesterone target genes [15]; FF no masking of NLSs by hormone-binding domain; FF cooperative PR binding to adjacent PREs mediates synergistic FF activation [4], [19]; XX IN T00698; PR; chick, Gallus gallus. IN T01660; PR A; chick, Gallus gallus. XX BS R00981; CHICK$LYS_09; Quality: 2; chick, Gallus gallus BS R02993; CHICK$PR_01; Quality: 1; chick, Gallus gallus BS R02994; CHICK$PR_02; Quality: 1; chick, Gallus gallus BS R02995; CHICK$PR_03; Quality: 1; chick, Gallus gallus BS R02996; CHICK$PR_04; Quality: 1; chick, Gallus gallus BS R01110; MMTV$MMTV_12; Quality: 1; MMTV, mouse mammary tumor virus BS R01120; MMTV$MMTV_22; Quality: 1; MMTV, mouse mammary tumor virus BS R01122; MMTV$MMTV_24; Quality: 1; MMTV, mouse mammary tumor virus BS R02234; PR$CONS; Quality: 6 BS R01481; RAT$TAT_02; Quality: 1; rat, Rattus norvegicus XX DR EMBL: Y00092; GGPGR(r). DR EMBL: M32726; GGPGRE02(r). DR EMBL: M32727; GGPGRE03(r). DR EMBL: M32728; GGPGRE04(r). DR EMBL: M32729; GGPGRE05(r). DR EMBL: M32730; GGPGRE06(r). DR EMBL: M32732; GGPGRE08(r). DR EMBL: M31104; GGPGRE1E(r). DR EMBL: M13972; GGPR(r). DR EMBL: M14278; GGPRA(r). DR EMBL: M14279; GGPRB(r). DR EMBL: M14280; GGPRC(r). DR SwissProt: P07812; PRGR_CHICK. DR PIR: A24312; A24312. DR PIR: A24661; A24661. DR PIR: S06284; S06284. XX RN [1] RA von der Ahe D., Renoir J.-M., Buchou T., Baulieu E.-E., Beato M. RT Receptors for glucocorticosteroid and progesterone RT recognize distinct features of a DNA regulatory element RL Proc. Natl. Acad. Sci. USA 83:2817-2821 (1986). RN [2] RA Ylikomi T., Bocquel M. T., Berry M., Gronemeyer H., Chambon P. RT Cooperation of proto-signals for nuclear accumulation RT of estrogen and progesterone receptors RL EMBO J. 11:3681-3694 (1992). RN [3] RA Eul J., Meyer M. E., Tora L., Bocquel M. T., Quirin-Stricker RA C., Chambon P., Gronemeyer H. RT Expression of active hormone and DNA-binding domains RT of the chicken progesterone receptor in E. coli RL EMBO J. 8:83-90 (1989). RN [4] RA Tsai S. Y., Tsai M.-J., O'Malley B. W. RT Cooperative Binding of Steroid Hormone Receptors Contribute RT to Transcriptional Synergism at Target Enhancer Elements RL Cell 57:443-448 (1989). RN [5] RA Tsai S. Y., Carlstedt-Duke J., Weigel N. L., Dahlmann RA K., Gustafsson J.-A., Tsai M.-J., O'Malley B. W. RT Molecular interactions of steroid hormone receptor RT with its enhancer element: evidence for receptor dimer formation RL Cell 55:361-369 (1988). RN [6] RA Conneely O. M., Sullivan W. P., Toft D. O., Birnbaumer RA M., Cook R. G., Maxwell B. L., Zarucki-Schulz T., RA Greene G. L., Schrader W. T., O'Malley B. W. RT Molecular cloning of the chicken progesterone receptor RL Science 233:767-770 (1986). RN [7] RA Jeltsch J. M., Krozowski Z., Quirin-Stricker C., Gronemeyer RA H., Simson R. J., Garnier J. M., Krust A., Jacob F., Chambon P. RT Cloning of the chicken progesterone receptor RL Proc. Natl. Acad. Sci. USA 83:5424-5428 (1986). RN [8] RA Smith D. F., Baggenstoss B. A., Marion T. N., Rimerman R. A. RT Two FBKP-related proteins are associated with progesterone receptor coplexes RL J. Biol. Chem. 268:18365-18371 (1993). RN [9] RA Kost S. L., Smith D. F., Sullivan W. P., Welch W. J., Toft D. O. RT Binding of heat shock proteins to the avian progesterone receptor RL Mol. Cell. Biol. 9:3829-3838 (1989). RN [10] RA Radanyi C., Renoir J.-M., Sabbah M., Baulieu E.-E. RT Chick heat-shock protein of Mr=90.000, free or released RT from progesterone receptor, is in a dimeric form RL J. Biol. Chem. 264:2568-2573 (1989). RN [11] RA Jeltsch J.-M., Turcotte B., Garnier J.-M., Lerouge RA T., Krozowski Z., Gronemeyer H., Chambon P. RT Characterization of multiple mRNA's originating from RT chicken progesterone receptor gene RL J. Biol. Chem. 265:3967-3974 (1990). RN [12] RA Evans R. M. RT The steroid and thyroid hormone receptor superfamily RL Science 240:889-895 (1988). RN [13] RA Schowalter D. P., Sullivan W. P., Maihle N. J., Dobson RA A. D. W., Conneely O. M., O'Malley B. W., Toft D. O. RT Characterization of progesterone receptor binding RT to the 90- and 70-kDa heat shock proteins RL J. Biol. Chem. 266:21165-21173 (1991). RN [14] RA Smith D. F., Faber L. E., Toft D. O. RT Purification of unactivated progesterone receptor RT and identification of novel receptor-associated proteins RL J. Biol. Chem. 265:3996-4003 (1990). RN [15] RA Tora L., Gronemeyer H., Turcotte B., Gaub M.-P., Chambon P. RT The N-terminal region of the chicken progesterone RT receptor specifies target gene activation RL Nature 333:185-188 (1988). RN [16] RA Schrader W. T., O'Malley B. W. RT Progesterone-binding components of chick oviduct RL J. Biol. Chem. 247:51-59 (1972). RN [17] RA Gronemeyer H., Govindan M. V., Chambon P. RT Immunological similarity between the chick oviduct RT progesterone receptor forms A and B RL J. Biol. Chem. 260:6916-6925 (1985). RN [18] RA Conneely O. M., Kettelberger D. M., Tsai M.-J., Schrader RA W. T., O'Malley B. W. RT The Chicken Progesterone Receptor A and B Isoforms RT Are Products of an Alternate Translation Initiation Event RL J. Biol. Chem. 264:14062-14064 (1989). RN [19] RA Klein-Hitpass L., Tsai S. Y., Weigel N. L., Allan RA G. F., Riley D., Rodriguez R., Schrader W. T., Tsai M.-J., O'Malley B. W. RT The Progesterone Receptor Stimulates Cell-Free Transcription RT by Enhancing the Formation of a Stable Preinitiation Complex RL Cell 60:247-257 (1990). RN [20] RA Turcotte B., Meyer M.-E., Bellard M., Dretzen G., Gronemeyer H., Chambon P. RT Control of transcription of the chicken progesterone receptor gene RL J. Biol. Chem. 266:2582-2589 (1991). RN [21] RA Biedenkapp H., Borgmeyer U., Sippel A., Klempnauer K.-H. RT Viral myb oncogene encodes a sequence-specific DNA-binding activity RL Nature 335:835-837 (1988). XX // AC T00699 XX ID T00699 XX DT 15.10.92 (created); ewi. DT 22.08.96 (updated); ewi. XX FA Prd XX SY Paired; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0018; paired-homeo; 3.2.1.0.1. XX SZ 613 AA; 65.5 kDa (DNA) XX SQ MTVTAFAAAMHRPFFNGYSTMQDMNSGQGRVNQLGGVFINGRPLPNNIRLKIVEMAADGI SQ RPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRIATPEIENRIEEYKRSSPGM SQ FSWEIREKLIREGVCDRSTAPSVSAISRLVRGRDAPLDNDMSSASGSPAGDGTKASSSCG SQ SDVSGGHHNNGKPSDEDISDCESEPGIALKRKQRRCRTTFSASQLDELERAFERTQYPDI SQ YTREELAQRTNLTEARIQVWFSNRRARLRKQHTSVSGGAPGGAAASVSHVAASSSLPSVV SQ SSVPSMAPLAMMPGSLDPATVYQQQYDFYGSHANISVSAAAPMASSNLSPGITTTPPHHH SQ QFYNPSANTASYIMPGENGNTTPTGNIIVSSYETQLGSVYGTETETHQTMPRNESPNESV SQ SSAFGQLPPTPNSLSAVVSGAGVTSSSGANSGADPSQSLANASAGSEELSAALKVESVDL SQ IAASQSQLYGGWSSMQALRPNAPLSPEDSLNSTSSTSQALDVTAHQMFHPYQHTPQYASY SQ PAPGHAHSHHGHPHAPHPHAHPHPQYAGAHPHYPPPSSSAHFMPQNFNAAAFPSPSKVNY SQ TTMPPQPFYPSWY XX SC SwissProt #P06601 XX FT 27 151 paired domain FT 213 272 homeo domain FT 27 96 N-terminal subdomain FT 30 42 beta-sheet-turn region (beta1-t1-beta2-t2) FT 46 58 alpha-helix 1 FT 63 69 alpha-helix 2 FT 73 86 alpha-helix 3 FT 104 154 C-terminal subdomain FT 105 114 alpha-helix 4 FT 122 132 alpha-helix 5 FT 143 154 alpha-helix 6 XX SF Prd(Q->K in position 9 of helix 3): gain of Ftz-like SF binding specificity [5]; SF distinct binding specificity for paired box and homeodomain [5], [6]; SF paired domain has two subdomains of three alpha-helices each [1]; SF DNA-contacts by helix 3, helices 1 and 2 antiparallel SF against each other and nearly perpendicular to helix 3 [1]; SF additional minor groove contacts by type II beta turn SF (39-42) and by the C-terminal tail of the N-terminal subdomain (91-98) [1]; SF no DNA-contacts observed by the similarly structured SF C-terminal subdomain [1]; SF typical fold of the homeo domain, direct contacts SF of the recognition helix plus extensive network of SF water molecules mediating additional major groove SF contacts of the recognition helix [2]; SF distortions of DNA conformation by the first bound SF molecule cause cooperative binding of a second one, SF both contacting each other through their homeo domains [2]; SF Gly-41->Ser mutation (analogous to undulated mutant SF in mice) abolishes DNA-binding by paired domain [6]; XX FF activator [7]; FF pair-rule gene product [7]; XX IN T00295; Ftz; fruit fly, Drosophila melanogaster. XX BS R01669; AS$FTZ_47; Quality: 2 BS R02485; AS$PRD_01; Quality: 6 BS R02810; AS$PRD_02; Quality: 6 BS R02811; AS$PRD_03; Quality: 6 BS R00411; DROME$EN_01; Quality: 6; fruit fly, Drosophila melanogaster BS R00419; DROME$EVE_02; Quality: 6; fruit fly, Drosophila melanogaster BS R02809; DROME$EVE_33; Quality: 6; fruit fly, Drosophila melanogaster BS R02484; DROME$HB_01; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: M14548; DMPRD(g). DR SwissProt: P06601; HMPR_DROME. DR PIR: A26062; A26062. DR Flybase: FBgn0003145; prd. XX RN [1] RA Xu W., Rould M. A., Jun S., Desplan C., Pabo C. O. RT Crystal structure of a paired domain-DNA complex at RT 2.5 A resolution reveals structural basis for Pax developmental mutations RL Cell 80:639-650 (1995). RN [2] RA Wilson D. S., Guenther B., Desplan C., Kuriyan J. RT High resolution crystal structure of a paired (Pax) RT class cooperative homeodomain dimer on DNA RL Cell 82:709-719 (1995). RN [3] RA Frigerio G., Burri M., Bopp D., Baumgartner S., Noll M. RT Structure of the segmentation gene paired and the RT Drosophila PRD gene set as part of a gene network RL Cell 47:735-746 (1986). RN [4] RA Hoey T., Levine M. RT Divergent homeo box proteins recognize similar DNA sequences in Drosophila RL Nature 332:858-861 (1988). RN [5] RA Treisman J., Goenczy P., Vashishta M., Harris E., Desplan C. RT A single amino acid can determine the DNA binding RT specificity of homeodomain proteins RL Cell 59:553-562 (1989). RN [6] RA Treisman J., Harris E., Desplan C. RT The paired box encodes a second DNA-binding domain RT in the Paired homeo domain protein RL Genes Dev. 5:594-604 (1991). RN [7] RA Morrissey D., Askew D., Raj L., Weir M. RT Functional dissection of the paired segmentation gene in Drosophila embryos RL Genes Dev. 5:1684-1696 (1991). XX // AC T00700 XX ID T00700 XX DT 27.01.93 (created); hse. DT 30.06.93 (updated); ewi. XX FA PTF XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 40 kDa (SDS, GF) XX CP pituitary XX FF may be a modified form of TFIID XX BS R02236; PTF$CONS; Quality: 6 BS R03451; RAT$GHF1_01; Quality: 6; rat, Rattus norvegicus BS R03452; RAT$GHF1_02; Quality: 6; rat, Rattus norvegicus XX RN [1] RA McCormick A., Brady H., Fukushima J., Karin M. RT The pituitary-specific regulatory gene GHF1 contains RT a minimal cell type-specific promoter centered around its TATA-box RL Genes Dev. 5:1490-1503 (1991). XX // AC T00701 XX ID T00701 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA PTF1-beta XX SY PTF-1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 48 + 64 kDa XX SF PTF1-beta comprises two subunits of 48 and 64 kDa SF it associates with a gp75 as a prerequisite for nuclear translocation [2]; XX CP pancreas XX BS R00106; MOUSE$AAMY_02; Quality: 6; mouse, Mus musculus BS R01835; MOUSE$AAMY_07; Quality: 6; mouse, Mus musculus BS R01836; MOUSE$AAMY_08; Quality: 6; mouse, Mus musculus BS R00409; MOUSE$EAII_03; Quality: 6; mouse, Mus musculus BS R01470; MOUSE$TA_03; Quality: 6; mouse, Mus musculus BS R01472; MOUSE$TD_01; Quality: 6; mouse, Mus musculus BS R02237; PTF1$CONS; Quality: 6 BS R00205; RAT$CAPEPA_01; Quality: 6; rat, Rattus norvegicus BS R00223; RAT$CHYB_01; Quality: 6; rat, Rattus norvegicus BS R00400; RAT$EAI_05; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Cockell M., Stevenson B. J., Strubin M., Hagenbuechle O., Wellauer P. K. RT Identification of a Cell-Specific DNA-Binding Activity RT That Interacts with a Transcriptional Activator of RT Genes Expressed in the Acinar Pancreas RL Mol. Cell. Biol. 9:2464-2476 (1989). RN [2] RA Sommer L., Hagenbuechle O., Wellauer P. K., Strubin M. RT Nuclear targeting of the transcription factor PTF1 RT is mediated by a protein subunit that does not bind RT to the PTF1 cognate sequence RL Cell 67:987-994 (1991). RN [3] RA Roux E., Strubin M., Hagenbuechle O., Wellauer P. K. RT The cell-specific transcription factor PTF1 contains RT two different subunits that interact with the DNA RL Genes Dev. 3:1613-1624 (1989). RN [4] RA Petrucco S., Wellauer P. K., Hagenbuechle O. RT The DNA-Binding Activity of Transcription Factor PTF1 RT Parallels the Synthesis of Pancreas-Specific mRNAs during Mouse Development RL Mol. Cell. Biol. 10:254-264 (1990). XX // AC T00702 XX ID T00702 XX DT 27.10.92 (created); ewi. DT 22.05.97 (updated); ewi. XX FA PU.1 XX SY B1; NF-JB; Spi-1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0016; ETS; 3.5.2.0.10. XX SZ 266 AA; 30.7 kDa (cDNA) XX SQ MEGFSLTAPPSDDLVTYDSELYQRPMHDYYSFVGSDGESHSDHYWDFSAHHVHNNEFENF SQ PENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHTGLSHQVSYMPRMCFPYQTLS SQ PAHQQSSDEEEGERQSPPLEVSDGEADGLEPGPGLLHGETGSKKKIRLYQFLLDLLRSGD SQ MKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKV SQ KKKLTYQFSGEVLGRGGLAERRLPPH XX SC SwissProt #P17433 XX FT 93 162 PEST region (required for intercation with NF-EM5 [9]; FT 148 148 Ser-phosphorylated by casein kinase II in vitro FT 169 209 tryptophan cluster (Y-X17-W-X21-W) FT 1 75 trans-activation domain, interacting with Rb and TBP [21]; FT 2 150 acidic region (27/149) FT 69 87 glutamine-rich region (6/19) FT 123 261 DNA binding domain [1]; FT 161 249 ETS domain FT 166 178 helix alpha1 FT 185 198 beta1/beta2 FT 201 209 helix alpha2 FT 220 231 recognition helix alpha3 FT 236 248 beta3/beta4 XX SF PU.1 lacks the mid-regional and the C-terminal region SF inhibiting DNA-binding in c-Ets-1 and -2 [4], [3]; SF its DNA-binding specificity also depends much more SF on sequences flanking the GGAA-core [4]; SF phosphtae backbone contacts and DNA distortion resemble SF those formed by homeo domain factors [12]; SF the bound 10bp DNA is uniformly curved by 8 deg [13]; SF the DNA-binding domain folds in alpha-helices and SF beta-strands according to the scheme alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4 SF [13]; SF alpha2-alpha3: helix-turn-helix-like motif with alpha3 SF as recognition helix, the sequence in between being SF a loop rather than a turn SF recognition helix performs major groove contacts in SF the GGAA core, the loop/turn between alpha2 and alpha3 SF binds to the backbone at a downstream nucleotide (ggaagT), SF and the loop between beta3 and beta4 makes upstream contacts [13]; SF the glutamine-rich region functions as a trans-activating domain [11]; XX CP B-cells, macrophages, erythroleukemia cells, spleen, CP thymus, mast cells, bone marrow, interstitial nonhepatocytes CP (liver), interstitial nontubular cells (testis) CN brain, heart, kidney, lung, T cells, fibroblasts, mesothelial cells XX FF acts as an activator [1] or as a repressor [19]; FF after phosphorylation at Ser-148 by CK II, PU.1 recruits FF NF-EM5 to bind to DNA resulting in pronounced transcriptional FF activation [9], [8]; FF PU.1 interferes with the commitment of erythroblast to differentiate [5]; FF activated by proviral integration of SFFV (anemia- FF or polycythemia-inducing strains) in 95% of leukemic cell clones [16]; XX IN T00722; Rb; human, Homo sapiens. IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. IN T01412; NF-EM5; mouse, Mus musculus. XX BS R04050; AS$ETS1_01; Quality: 6 BS R04051; AS$ETS1_02; Quality: 6 BS R04052; AS$ETS1_03; Quality: 6 BS R04049; AS$PU1_01; Quality: 6 BS R02386; DROME$E74_09; Quality: 5; fruit fly, Drosophila melanogaster BS R04069; FMULV$FMULV_01; Quality: 5; F-MuLV, friend murine leukemia virus BS R01711; HS$GP2B_06; Quality: 5; human, Homo sapiens BS R04413; MOUSE$FCGR3A_02; Quality: 3; mouse, Mus musculus BS R02685; MOUSE$IGH_47; Quality: 5; mouse, Mus musculus BS R02982; MOUSE$IGKL_24; Quality: 2; mouse, Mus musculus BS R01068; MOUSE$M2IAB_01; Quality: 1; mouse, Mus musculus BS R03475; MOUSE$MB1_01; Quality: 5; mouse, Mus musculus BS R01155; MSV$MSV_03; Quality: 5; MSV, murine sarcoma virus BS R02238; PU1$CONS; Quality: 6 BS R03675; SV$SV40_62; Quality: 2; SV40, simian virus 40 XX DR EMBL: M32370; MMPU1(r). DR EMBL: M38252; MMSFPI1(r). DR EMBL: X17463; MMSPI14(r). DR SwissProt: P17433; PU1_MOUSE. DR PIR: A34693; A34693. DR PIR: S10258; S10258. DR PIR: S12467; S12467. DR Compel: C00024 DR Compel: C00025 XX RN [1] RA Klemsz M. J., McKercher S. R., Celada A., van Beveren C., Maki R. A. RT The macrophage and B cell-specific transcription factor RT PU.1 is related to the ets oncogene RL Cell 61:113-124 (1990). RN [2] RA Buchanan R. L., Gralla J. D. RT Factor Interaction at Simian Virus 40 GC-Box Promoter RT Elements in Intact Nuclei RL Mol. Cell. Biol. 7:1554-1558 (1987). RN [3] RA Hagman J., Grosschedl R. RT An inhibitory carboxyl-terminal domain in Ets-1 and RT Ets-2 mediates differential binding of Ets family RT factors to promoter sequences of the mb-1 gene RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992). RN [4] RA Wasylyk C., Kerckaert J.-P., Wasylyk B. RT A novel modulator domain of Ets transcription factors RL Genes Dev. 6:965-974 (1992). RN [5] RA Schuetze S., Paul R., Gliniak B. C., Kabat D. RT Role of the PU.1 transcription factor in controlling RT differentiation of friend erythroleukemia cells RL Mol. Cell. Biol. 12:2967-2975 (1992). RN [6] RA Fisher R. J., Koizumi S., Kondoh A., Mariano J. M., RA Mavrothalassitis G., Bhat N. K., Papas T. S. RT Human Ets1 oncoprotein RL J. Biol. Chem. 267:17957-17965 (1992). RN [7] RA Zhang L., Lemarchandel V., Romeo P.-H., Ben-David Y., Greer P., Bernstein A. RT The Fli-1 proto-oncogene, involved in erythroleukemia RT and Ewing`s sarcoma, encodes a transcriptional activator RT with DNA-binding specifities distinct from other Ets family members RL Oncogene 8:1621-1630 (1993). RN [8] RA Pongubala J. M. R., van Beveren C., Nagulapalli S., RA Klemsz M. J., McKercher S. R., Maki R. A., Atchison M. L. RT Effect of PU.1 phosphorylation on interaction with RT NF-EM5 and transcriptional activation RL Science 259:1622-1625 (1993). RN [9] RA Pongubala J. M. R., Nagulapalli S., Klemsz M. J., RA McKercher S. R., Maki R. A., Atchison M. L. RT PU.1 recruits a second nuclear factor to a site important RT for immunoglobulin kappa 3' enhancer activity RL Mol. Cell. Biol. 12:368-378 (1992). RN [10] RA Eisenbeis C. F., Singh H., Storb U. RT Pip, a novel IRF family member, is a lymphoid-specific, RT PU.1-dependent transcriptional activator RL Genes Dev. 9:1377-1387 (1995). RN [11] RA Shin M. K., Koshland M. E. RT Ets-related protein PU.1 regulates expression of the RT immunoglibulin J-chain gene through a novel Ets-binding element RL Genes Dev. 7:2006-2015 (1993). RN [12] RA Galson D. L., Hensold J. O., Bishop T. R., Schalling RA M., D'Andrea A. D., Jones C., Auron P. E., Housman D. E. RT Mouse beta-globin DNA-binding protein B1 is identical RT to a proto-oncogene, the transcription factor Spi-1/PU.1, RT and is restricted in expression to hematopoietic cells and the testis RL Mol. Cell. Biol. 13:2929-2941 (1993). RN [13] RA Kondandapani R., Plo F., Ni C.-Z., Piccialli G., Klemsz RA M., McKercher S., Maki R. A., Ely K. R. RT A new pattern for helix-turn-helix recognition revealed RT by the PU.1 ETS-domain-DNA complex RL Nature 380:456-460 (1996). RN [14] RA Celada A., Shiga M., Imagawa M., Kop J., Maki R. A. RT Identification of a nuclear factor that binds to a RT conserved sequence of the I-A-beta gene RL J. Immunology 140:3995-4002 (1988). RN [15] RA Moreau-Gachelin F., Tavitian A., Tambourin P. RT Spi-1 is a putative oncogene in virally induced murine erythroleukemias RL Nature 331:277-280 (1988). RN [16] RA Moreau-Gachelin F., Ray D., Mattei M.-G., Tambourin P., Tavitian A. RT The putative oncogene Spi-1: murine chromosomal localization RT and transcriptional activation in murine acute erythroleukemias RL Oncogene 4:1449-1456 (1989). RN [17] RA Ray D., Culine S., Tavitian A., Moreau-Gachelin F. RT The human homologue of the putative proto-oncogene RT Spi-1: characterization and expression in tumors RL Oncogene 5:663-668 (1990). RN [18] RA Eisenbeis C. F., Singh H., Storb U. RT PU.1 is a component of a multiprotein complex which RT binds an essential site in the murine immunoglobulin 82-4 enhancer RL Mol. Cell. Biol. 13:6452-6461 (1993). RN [19] RA Ross I. L., Dunn T. L., Yue X., Roy S., Barnett C. J. K., Hume D. A. RT Comparison of the expression and function of the transcription RT factor PU.1 (SPI-1 proto-oncogene) between murine RT macrophages and B lymphocytes RL Oncogene 9:121-132 (1994). RN [20] RA Pongubala J. M. R., Atchison M. L. RT Functional characterization of the developmentally RT controlled immunoglobulin kappa 3' enhancer: regulation RT by Id, a repressor of helix-loop-helix transcription factors RL Mol. Cell. Biol. 11:1040-1047 (1991). RN [21] RA Hagemeier C., Bannister A. J., Cook A., Kouzarides T. RT The activation domain of transcription factor PU.1 RT binds the retinoblastoma (RB) protein and the transcription RT factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB RL Proc. Natl. Acad. Sci. USA 90:1580-1584 (1993). XX // AC T00703 XX ID T00703 XX DT 27.01.93 (created); hse. XX FA Pu.1 XX SY PU.1; Spi-1 (mouse); XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CP B lymphocytes and macrophages XX IN T00722; Rb; human, Homo sapiens. IN T00794; TBP; human, Homo sapiens. IN T01412; NF-EM5; mouse, Mus musculus. XX BS R02238; PU1$CONS; Quality: 6 XX RN [1] RA Goebl M. G., Moreau-Gachelin F., Ray D., Tambourin P., Tavitian A. RT The PU.1 transcription factor is the product of the putative oncogene Spi-1 RL Cell 61:1165-1166 (1990). RN [2] RA Paul R., Schuetze S., Kozak S. L., Kozak C. A., Kabat D. RT The Sfpi-1 proviral integration site of friend erythroleukemia RT encodes the ets-related transcription factor Pu.1 RL J. Virol. 65:464-467 (1991). XX // AC T00704 XX ID T00704 XX DT 15.10.92 (created); ewi. XX FA Pu box binding factor XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP T cells XX BS R01654; LPV$LPV_03; Quality: 6; LPV, lymphotropic papova virus BS R02348; MOUSE$IL2_01; Quality: 6; mouse, Mus musculus BS R02349; MOUSE$IL2_02; Quality: 6; mouse, Mus musculus XX RN [1] RA Erselius J. R., Jostes B., Hatzopoulos A. K., Mosthaf L., Gruss P. RT Cell-Type-Specific Control Elements of the Lymphotropic Papovavirus Enhancer RL J. Virol. 64:1657-1666 (1990). XX // AC T00705 XX ID T00705 XX DT 15.10.92 (created); ewi. XX FA Pu box binding factor (BJA-B) XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP B-cells XX BS R01653; LPV$LPV_02; Quality: 6; LPV, lymphotropic papova virus XX RN [1] RA Erselius J. R., Jostes B., Hatzopoulos A. K., Mosthaf L., Gruss P. RT Cell-Type-Specific Control Elements of the Lymphotropic Papovavirus Enhancer RL J. Virol. 64:1657-1666 (1990). XX // AC T00706 XX ID T00706 XX DT 15.10.92 (created); ewi. DT 05.04.94 (updated); hwi; hse; ewi. XX FA PuF XX SY nm23-H2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ >17 kDa (cDNA) XX CP (HeLa) XX FF activator; FF nucleoside disphosphate kinase; FF acts on c-myc gene promoter XX BS R01804; HS$CMYC_04; Quality: 6; human, Homo sapiens BS R02239; PUF$CONS; Quality: 6 XX DR EMBL: L16785; HSPUF(r). XX RN [1] RA Postel E. H., Berberich S. J., Flint S. J., Ferrone C. A. RT Human c-myc transcription factor PuF identified as RT nm23-H2 nucleoside diphospate kinase, a candidate RT suppressor of tumor metastasis RL Science 261:478-480 (1993). RN [2] RA Postel E. H., Mango S. E., Flint S. J. RT A Nuclease-Hypersensitive Element of the Human c-myc RT Promoter Interacts with a Transcription Initiation Factor RL Mol. Cell. Biol. 9:5123-5133 (1989). XX // AC T00707 XX ID T00707 XX DT 15.10.92 (created); ewi. XX FA PUF-I XX SY GHF-2; LSF-1; PUF-1; Pit-1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 33.0 + 34.5 kDa (SDS) XX CP pituitary gland XX BS R02160; GHF1$CONS; Quality: 6 BS R01279; RAT$PL_18; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Cao Z., Barron E. A., Carillo A. J., Sharp Z. D. RT Reconstitution of Cell-Type-Specific Transcription RT of the Rat Prolactin Gene In Vitro RL Mol. Cell. Biol. 7:3402-3408 (1987). RN [2] RA Cao Z., Barron E. A., Sharp Z. D. RT Prolactin Upstream Factor I Mediates Cell-Specific Transcription RL Mol. Cell. Biol. 8:5432-5438 (1988). RN [3] RA Sharp Z. D., Helsel S., Cao Z., Barron E. A., Sanchez Y. RT DNA recognition element required for PUF-I mediated RT cell-type specific transcription of the rat prolactin gene RL Nucleic Acids Res. 17:2705-2722 (1989). XX // AC T00708 XX ID T00708 XX DT 15.10.92 (created); ewi. DT 05.04.94 (updated); hwi. XX FA p40x XX OS HTLV-I, human T-cell lymphotropic virus type I OC viridae; ss-RNA enveloped viruses; positive strand OC RNA viruses; retroviridae; oncovirinae; type C oncovirus OC group; mammalian type C oncoviruses XX SZ 40 kDa XX DR EMBL: M16781; AGPROA(g). DR EMBL: M16782; AGPROB(g). DR EMBL: M16783; AGPROC(g). DR EMBL: M16784; AGPROD(g). XX RN [1] RA Seiki M., Inoue J.-I., Takeda T., Yoshida M. RT Direct evidence that p40kappa of human T-cell leukemia RT virus type I is a trans-acting transcriptional activator RL EMBO J. 5:561-565 (1986). XX // AC T00709 XX ID T00709 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA qa-1F XX OS Neurospora crassa OC eukaryota; plantae; thallobionta; eumycota; ascomycotina; OC pyrenomycetes; sordariales; sordariaceae XX CL C0004; CC; 2.4.1.0.8. XX SZ 89 kDa XX SQ MPPKRKTLNAAAEANAHADGHADGNADGHVANTAASSNNARFADLTNIDTPGLGPTTTTL SQ LVEPARSKRQRVSRACDQCRAAREKCDGIQPACFPCVSQGRSCTYQASPKKRGVQTGYIR SQ TLELALAWMFENVARSEDALHNLLVRDAGQGSALLVGKDSPAAERLHARWATSRVNKSIT SQ RLLSGQAAQDPSEDGQSPSEDINVQDAGAKTSDFPHAPHLTFSAPKSSTAETRTLPGPVR SQ PPISANTLENNLQPDGTGIGKLPPNHWRLLDIYFSYTHSWLPILEKKDMYQALYQYSEQG SQ SLLPSANVESGVHAELWSALALASFQAAATAASSATGPASAAHGHDNAINPSPADISDTA SQ RKLIPLESGPFQVQHCRALLLLCLVSLGRDDWESAWLLVGFAVRVLLVVRTQLPPDDDRP SQ RPRMRALLVACFIVDTIVSMRHNVPAHLKPDDIADLPLPEDGQDQWEPWTPCEGLGGEHT SQ MLQMLRNPAYPLSTFNHLYGVTKLVALELLPRIRTSSQNAPLEFRSRLQQVIGHNSPFSV SQ FVLSQDTASAFVPTAYLTRTVYLWAAAFSEPLNEHYSHLLIETLDQYQKRFGTYAIPPLI SQ PSLLDSLLALKKQSHSSERHRRHLEELFPAYSSIWPRGGRHSNTGLQPIRQLELPPTATA SQ TASIMPHVMEQPLSTSINPVNDRFNGIPNPTPYNSDAALDAITQTNDYGSVNTHGILSTY SQ PPPATHLNEASVALAPGGAPPRPPPPYVDSTTNHPPYHSNLVPMANFGYSTVDYDAMVDD SQ LASIEYTDAVDVDPQFMTNLGFVPGCNFSDINTYEQ XX SC SwissProt #P11638 XX SF 1 zinc finger motif XX FF activator of genes that allow utilization of quinic acid as carbon source XX MX M00047; F$QA1F_01 XX BS R01302; NEUCR$QA1F_01; Quality: 2; Neurospora crassa BS R01303; NEUCR$QA1F_02; Quality: 2; Neurospora crassa BS R01301; NEUCR$QA1S_01; Quality: 2; Neurospora crassa BS R01290; NEUCR$QA2Q_01; Quality: 2; Neurospora crassa BS R01291; NEUCR$QA2_01; Quality: 2; Neurospora crassa BS R01292; NEUCR$QA2_02; Quality: 2; Neurospora crassa BS R01295; NEUCR$QA3_01; Quality: 2; Neurospora crassa BS R01296; NEUCR$QA3_02; Quality: 2; Neurospora crassa BS R01297; NEUCR$QA3_03; Quality: 2; Neurospora crassa BS R01293; NEUCR$QA4_01; Quality: 2; Neurospora crassa BS R01294; NEUCR$QA4_02; Quality: 2; Neurospora crassa BS R01298; NEUCR$QAY_01; Quality: 2; Neurospora crassa BS R01299; NEUCR$QAY_02; Quality: 2; Neurospora crassa BS R01300; NEUCR$QAY_03; Quality: 2; Neurospora crassa XX DR EMBL: X14603; NCQA(g). DR SwissProt: P11638; QA1F_NEUCR. DR PIR: F31277; F31277. DR PIR: S04256; S04256. XX RN [1] RA Baum J. A., Geever R., Giles N. H. RT Expression of qa-1F activator protein: identification RT of upstream binding sites in the qa gene cluster and RT localization of the DNA-binding domain RL Mol. Cell. Biol. 7:1256-1266 (1987). XX // AC T00710 XX ID T00710 XX DT 21.01.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA R XX SY BRLF1; R factor; factor R; XX OS EBV, Epstein-Barr virus OC viridae; ds-DNA enveloped viruses; herpesviridae; gammaherpesviridae XX SZ 605 AA; 66.6 kDa (cDNA) XX SQ MRPKKDGLEDFLRLTPEIKKQLGSLVSDYCNVLNKEFTAGSVEITLRSYKICKAFINEAK SQ AHGREWGGLMATLNICNFWAILRNNRVRRRAENAGNDACSIACPIVMRYVLDHLIVVTDR SQ FFIQAPSNRVMIPATIGTAMYKLLKHSRVRAYTYSKVLGVDRAAIMASGKQVVEHLNRME SQ KEGLLSSKFKAFCKWVFTYPVLEEMFQTMVSSKTGHLTDDVKDVRALIKTLPRASYSSHA SQ GQRSYVSGVLPACLLSTKSKAVETPILVSGADRMDEELMGNDGGASHTEARYSESGQFHA SQ FTDELESLPSPTMPLKPGAQSADCGDSSSSSSDSGNSDTEQSEREEARAEAPRLRAPKSR SQ RTSRPNRGQTPCPSNAAEPEQPWIAAVHQESDERPIFPHPSKPTFLPPVKRKKGLRDSRE SQ GMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWANRPLPASLAPTPTGPVHEPVG SQ SLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQMD SQ LSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIF SQ DTSLF XX SC SwissProt #P03209 XX FF synergizes with Zta (BZLF1, EB1) XX BS R04003; EBV$BMLF1_01; Quality: 2; EBV, Epstein-Barr virus BS R02816; EBV$IR4_04; Quality: 6; EBV, Epstein-Barr virus BS R02817; EBV$IR4_05; Quality: 6; EBV, Epstein-Barr virus BS R02818; EBV$IR4_06; Quality: 6; EBV, Epstein-Barr virus XX DR EMBL: V01555; EBV(g). DR SwissProt: P03209; BRL1_EBV. DR PIR: A43043; QQBE29. XX RN [1] RA Gruffat H., Manet E., Rigolet A., Sergeant A. RT The enhancer factor R of Epstein-Barr virus (EBV) RT is a sequence-specific DNA binding protein RL Nucleic Acids Res. 18:6835 (1990). RN [2] RA Giot F.-F., Mikaelian I., Buisson M., Manet E., Joab RA I., Nicolas J.-C., Sergeant A. RT Transcriptional interference between the EBV transcription RT factors EB1 and R: both DNA-binding and activation RT domains of EB1 are required RL Nucleic Acids Res. 19:1251-1258 (1991). RN [3] RA Manet E., Rigolet A., Gruffat H., Giot J., Sergeant A. RT Domains of the Epstein-Barr virus (EBV) transcription RT factor R required for dimerization, DNA binding and activation RL Nucleic Acids Res. 19:2661 (1991). XX // AC T00711 XX ID T00711 XX DT 15.10.92 (created); ewi. XX FA R1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01005; AD$MLP_20; Quality: 6; adenovirus BS R00921; HS$IFNB_06; Quality: 6; human, Homo sapiens BS R00161; HS$OAS_02; Quality: 6; human, Homo sapiens BS R03041; MOUSE$THY1_01; Quality: 6; mouse, Mus musculus BS R03044; MOUSE$THY1_04; Quality: 6; mouse, Mus musculus XX RN [1] RA Zinn K., Maniatis T. RT Detection of factors that interact with the human RT beta-interferon regulatory region in vivo by DNAase I footprinting RL Cell 45:611-618 (1986). RN [2] RA Spanopoulou E., Giguere V., Grosveld F. RT The functional domains of the murine Thy-1 gene promoter RL Mol. Cell. Biol. 11:2216-2228 (1991). XX // AC T00712 XX ID T00712 XX DT 15.10.92 (created); ewi. XX FA R2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R01007; AD$MLP_22; Quality: 6; adenovirus BS R00916; HS$IFNB_01; Quality: 6; human, Homo sapiens BS R00162; HS$OAS_03; Quality: 6; human, Homo sapiens BS R03041; MOUSE$THY1_01; Quality: 6; mouse, Mus musculus BS R03044; MOUSE$THY1_04; Quality: 6; mouse, Mus musculus XX RN [1] RA Zinn K., Maniatis T. RT Detection of factors that interact with the human RT beta-interferon regulatory region in vivo by DNAase I footprinting RL Cell 45:611-618 (1986). RN [2] RA Spanopoulou E., Giguere V., Grosveld F. RT The functional domains of the murine Thy-1 gene promoter RL Mol. Cell. Biol. 11:2216-2228 (1991). XX // AC T00713 XX ID T00713 XX DT 15.10.92 (created); ewi. XX FA Rad-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (lymphocytes) XX BS R01648; RADLV$RLV_07; Quality: 6; RadLV (BL/VL3 Kaplan radiation leukemia virus) XX RN [1] RA Gorska-Flipot I., Jolicoeur P. RT DNA-Binding Proteins That Interact with the Long Terminal RT Repeat of Radiation Leukemia Virus RL J. Virol. 64:1566-1572 (1990). XX // AC T00714 XX ID T00714 XX DT 15.10.92 (created); ewi. XX FA RAF XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX BS R00256; Y$CYC1_03; Quality: 4; yeast, Saccharomyces cerevisiae XX RN [1] RA Pfeifer K., Arcangioli B., Guarente L. RT Yeast HAP1 activator competes with the factor RC2 RT for binding to the upstream activation site UAS1 of the CYC1 gene RL Cell 49:9-18 (1987). XX // AC T00715 XX ID T00715 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA RAP1 XX SY GRFI; SBF-E; TUF; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 3.5.1.2.5. XX SZ 827 AA; 92.5 kDa(gene), 135 kDa(SDS), 300 kDa(GF) XX SQ MSSPDDFETAPAEYVDALDPSMVVVDSGSAAVTAPSDSAAEVKANQNEENTGATAAETSE SQ KVDQTEVEKKDDDDTTEVGVTTTTPSIADTAATANIASTSGASVTEPTTDDTAADEKKEQ SQ VSGPPLSNMKFYLNRDADAHDSLNDIDQLARLIRANGGEVLDSKPRESKENVFIVSPYNH SQ TNLPTVTPTYIKACCQSNSLLNMENYLVPYDNFREVVDSRLQEESHSNGVDNSNSNSDNK SQ DSIRPKTEIISTNTNGATEDSTSEKVMVDAEQQARLQEQAQLLRQHVSSTASITSGGHND SQ LVQIEQPQKDTSNNNNSNVNDEDNDLLTQDNNPQTADEGNASFQAQRSMISRGALPSHNK SQ ASFTDEEDEFILDVVRKNPTRRTTHTLYDEISHYVPNHTGNSIRHRFRVYLSKRLEYVYE SQ VDKFGKLVRDDDGNLIKTKVLPPSIKRKFSADEDYTLAIAVKKQFYRDLFQIDPDTGRSL SQ ITDEDTPTAIARRNMTMDPNHVPGSEPNFAAYRTQSRRGPIAREFFKHFAEEHAAHTENA SQ WRDRFRKFLLAYGIDDYISYYEAEKAQNREPEPMKNLTNRPKRPGVPTPGNYNSAAKRAR SQ NYSSQRNVQPTANAASANAAAAAAAAASNSYAIPENELLDEDTMNFISSLKNDLSNISNS SQ LPFEYPHEIAEAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKL SQ HEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSGDLMVFPRYFLNMFKDNVNPP SQ PNVPGIWTHDDDESLKSNDQEQIRKLVKKHGTGRMEMRKRFFEKDLL XX SC SwissProt #P11938 XX SF MW may vary between 120-150 kDa when determined by SDS-PAGE XX FF repressor or activator, depending on context; FF activates glycolytic genes, represses silent mating loci HML and HMR; FF involved in telomer and protein stability XX MX M00213; F$RAP1_C XX BS R02393; AS$TEL_01; Quality: 6 BS R02394; AS$TEL_02; Quality: 6 BS R02395; AS$TEL_03; Quality: 6 BS R02761; AS$TUF_01; Quality: 6 BS R02762; AS$TUF_02; Quality: 6 BS R02763; AS$TUF_03; Quality: 6 BS R02764; AS$TUF_04; Quality: 6 BS R02765; AS$TUF_05; Quality: 6 BS R02766; AS$TUF_06; Quality: 6 BS R02767; AS$TUF_07; Quality: 6 BS R02768; AS$TUF_08; Quality: 6 BS R02769; AS$TUF_09; Quality: 6 BS R02770; AS$TUF_10; Quality: 6 BS R02771; AS$TUF_11; Quality: 6 BS R02772; AS$TUF_12; Quality: 6 BS R02773; AS$TUF_13; Quality: 6 BS R01924; AS$TUF_14; Quality: 4 BS R03739; TUF$CONS_01; Quality: 6 BS R00073; Y$ADH1_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R00166; Y$BCY_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R00415; Y$ENO1_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R00416; Y$ENO1_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R02799; Y$ENO2_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R03807; Y$ENO2_04; Quality: 2; yeast, Saccharomyces cerevisiae BS R00714; Y$HML_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R00717; Y$HMR_02; Quality: 4; yeast, Saccharomyces cerevisiae BS R00972; Y$LSR_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R01019; Y$MATAL_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R02917; Y$PDC1_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R01199; Y$PGK_02; Quality: 1; yeast, Saccharomyces cerevisiae BS R01210; Y$PHO5_04; Quality: 1; yeast, Saccharomyces cerevisiae BS R01289; Y$PYK1_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R02417; Y$PYK1_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R03676; Y$PYK1_04; Quality: 6; yeast, Saccharomyces cerevisiae BS R01820; Y$RNR2_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R01822; Y$RNR2_03; Quality: 4; yeast, Saccharomyces cerevisiae BS R01332; Y$RP28_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01333; Y$RP28_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R01334; Y$RP51A_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01335; Y$RP51A_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R03124; Y$RPL16A_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R01331; Y$RPL25_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01337; Y$RPS24_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01338; Y$RPS24_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R01356; Y$SIR3D_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R00372; Y$TEF1_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R00373; Y$TEF2_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R03788; Y$TIP1_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R04074; Y$TPI_02; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: M18068; YSRAP1A(g). DR SwissProt: P11938; RAP1_YEAST. DR PIR: A29620; A29620. DR PDB: 1ign; DNA-BINDING DOMAIN OF RAP1 IN COMPLEX WITH TELOMERIC DNA SITE YEAST. XX RN [1] RA Shore D., Nasmyth K. RT Purification and Cloning of a DNA Binding Protein RT from Yeast That Binds to Both Silencer and Activator Elements RL Cell 51:721-732 (1987). RN [2] RA Buchman A. R., Lue N. F., Kornberg R. D. RT Connections between Transcriptional Activators, Silencers, RT and Telomeres as Revealed by Functional Analysis of RT a Yeast DNA-Binding Protein RL Mol. Cell. Biol. 8:5086-5099 (1988). RN [3] RA Vignais M.-L., Woudt L. P., Wassenaar G. M., Mager RA W. H., Sentenac A., Planta R. J. RT Specific binding of TUF factor to upstream activation RT sites of yeast ribosomal protein genes RL EMBO J. 6:1451-1457 (1987). RN [4] RA Sousa R., Arcangioli B. RT A point mutation in the CYC1 UAS1 creates a new combination RT of regulatory elements that activate transcription synergistically RL EMBO J. 8:1801-1808 (1989). RN [5] RA Hurd H. K., Roberts J. W. RT Upstream Regulatory Sequences of the Yeast RNR2 Gene RT Include a Repression Sequence and an Activation Site RT That Binds the RAP1 Protein RL Mol. Cell. Biol. 9:5359-5372 (1989). RN [6] RA Chambers A., Tsang J. S. H., Stanway C., Kingsman A. J., Kingsman S. M. RT Transcriptional Control of the Saccharomyces cerevisiae PGK Gene by RAP1 RL Mol. Cell. Biol. 9:5516-5524 (1989). RN [7] RA Huet J., Cottrelle P., Cool M., Vignais M.-L., Thiele RA D., Marck C., Buhler J.-M., Sentenac A., Fromageot P. RT A general upstream binding factor for genes of the RT yeast translational apparatus RL EMBO J. 4:3539-3547 (1985). RN [8] RA Santangelo G. M., Tornow J. RT Efficient Transcription of the Glycolytic Gene ADH1 RT and Three Translational Component Genes Requires the RT GCR1 Product, Which Can Act Through TUF/GRF/RAP Binding Sites RL Mol. Cell. Biol. 10:859-862 (1990). RN [9] RA Vignais M.-L., Huet J., Buhler J.-M., Sentenac A. RT Contacts between the factor TUF and RPG sequences RL J. Biol. Chem. 256:14669-14674 (1990). RN [10] RA Shore D., Stillman D. J., Brand A. H., Nasmyth K. A. RT Identification of silencer binding proteins from yeast: RT possible roles in SIR control and DNA replication RL EMBO J. 6:461-467 (1987). RN [11] RA Buchman A. R., Kimmerley W. J., Rine J., Kornberg R. D. RT Two DNA-Binding Factors Recognize Specific Sequences RT at Silencers, Upstream Activating Sequences, Autonomously RT Replicating Sequences, and Telomeres in Saccharomyces cerevisiae RL Mol. Cell. Biol. 8:210-225 (1988). RN [12] RA Kimmerly W., Buchman A., Kornberg R., Rine J. RT Roles of two DNA-binding factors in replication, segregation RT and transcriptional repression mediated by a yeast silencer RL EMBO J. 7:2241-2253 (1988). RN [13] RA Kurtz S., Shore D. RT RAP1 protein activates and silences transcription RT of mating-type genes in yeast RL Genes Dev. 5:616-628 (1991). RN [14] RA Moehle C. M., Hinnebusch A. G. RT Association of RAP1 binding sites with stringent control RT of ribosomal protein gene transcription in Saccharomyces cerevisiae RL Mol. Cell. Biol. 11:2723-2735 (1991). XX // AC T00716 XX ID T00716 XX DT 27.01.93 (created); hse. XX FA RAR XX SY retinoic acid receptor; XX OS monkey, Cercopithecus aethiops OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; primates; haplorhini; OC catarrhini; cercopithecidae; cercopithecinae XX CL C0002; CC (rec); . XX SZ 48.5 kDa (SDS), 49.9 kDa (cDNA) XX FF member of the steroid hormone receptor superfamily; FF 3 subtypes (alpha, beta, gamma) XX IN T00836; T3R; mouse, Mus musculus. IN T00837; T3R; chick, Gallus gallus. IN T00838; T3R; human, Homo sapiens. IN T00839; T3R; rat, Rattus norvegicus. IN T00840; T3R; rat, Rattus norvegicus. IN T00854; T3R; monkey, Cercopithecus aethiops. XX BS R02240; RAR$CONS; Quality: 6 XX RN [1] RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado RA J., Pike J. W., Evans R. M. RT Jun-Fos and receptors for vitamins A and D recognize RT a common response element in the human osteocalcin gene RL Cell 61:497-504 (1990). RN [2] RA Glass C. K., Devary O. V., Rosenfeld M. G. RT Multiple cell type-specific proteins differentially RT regulate target sequence recognition by the alpha retinoic acid receptor RL Cell 63:729-738 (1990). RN [3] RA Ellinger-Ziegelbauer H., Dreyer C. RT A retinoic acid receptor expressed in the early development RT of Xenopus laevis RL Genes Dev. 5:94-104 (1991). RN [4] RA Rowe A., Eager N. S. C., Brickell P. M. RT A member of the RXR nuclear receptor family is expressed RT in neural-crest-derived cells of the developing chick RT peripheral nervous system RL Development 111:771-778 (1991). RN [5] RA Vasios G., Mader S., Gold J. D., Leid M., Lutz Y., RA Gaub M.-P., Chambon P., Gudas L. RT The late retinoic acid induction of laminin B1 gene RT transcription involves RAR binding to the responsive element RL EMBO J. 10:1149-1158 (1991). XX // AC T00717 XX ID T00717 XX DT 27.01.93 (created); hse. DT 10.01.96 (updated); hiwi. XX FA RAR XX SY retinoic acid receptor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.2.1.2.3. XX SZ 447-482 AA; 49.8-53.3 kDa (cDNA) XX SF two splice variants from RAR-alpha, three from RAR-beta, two from RAR-gamma XX FF member of the steroid hormone receptor superfamily; FF 3 subtypes (alpha, beta, gamma) XX IN T00836; T3R; mouse, Mus musculus. IN T00837; T3R; chick, Gallus gallus. IN T00838; T3R; human, Homo sapiens. IN T00839; T3R; rat, Rattus norvegicus. IN T00840; T3R; rat, Rattus norvegicus. IN T00854; T3R; monkey, Cercopithecus aethiops. XX BS R02240; RAR$CONS; Quality: 6 XX DR EMBL: X56572; MMRARA1(r). DR EMBL: X56565; MMRARA2(r). DR EMBL: X56569; MMRARB1(r). DR EMBL: X56573; MMRARB2(r). DR EMBL: X56574; MMRARB3(r). DR EMBL: M32068; MMRARG1(r). DR EMBL: M32069; MMRARG2(r). DR EMBL: M34476; MMRARGA(r). DR EMBL: M34475; MMRARGB(r). DR SwissProt: P11416; RRA1_MOUSE. DR SwissProt: P22603; RRA2_MOUSE. DR SwissProt: P22604; RRB1_MOUSE. DR SwissProt: P11417; RRB2_MOUSE. DR SwissProt: P22605; RRB3_MOUSE. DR SwissProt: P18911; RRG1_MOUSE. DR SwissProt: P20787; RRG2_MOUSE. DR PIR: B34714; B34714. DR PIR: B35991; B35991. XX RN [1] RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado RA J., Pike J. W., Evans R. M. RT Jun-Fos and receptors for vitamins A and D recognize RT a common response element in the human osteocalcin gene RL Cell 61:497-504 (1990). RN [2] RA Glass C. K., Devary O. V., Rosenfeld M. G. RT Multiple cell type-specific proteins differentially RT regulate target sequence recognition by the alpha retinoic acid receptor RL Cell 63:729-738 (1990). RN [3] RA Ellinger-Ziegelbauer H., Dreyer C. RT A retinoic acid receptor expressed in the early development RT of Xenopus laevis RL Genes Dev. 5:94-104 (1991). RN [4] RA Rowe A., Eager N. S. C., Brickell P. M. RT A member of the RXR nuclear receptor family is expressed RT in neural-crest-derived cells of the developing chick RT peripheral nervous system RL Development 111:771-778 (1991). RN [5] RA Vasios G., Mader S., Gold J. D., Leid M., Lutz Y., RA Gaub M.-P., Chambon P., Gudas L. RT The late retinoic acid induction of laminin B1 gene RT transcription involves RAR binding to the responsive element RL EMBO J. 10:1149-1158 (1991). XX // AC T00718 XX ID T00718 XX DT 27.01.93 (created); hse. XX FA RAR XX SY retinoic acid receptor; XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX CL C0002; CC (rec); . XX SZ 49.9 kDa (cDNA), 48.5 kDa (SDS) XX FF member of the steroid hormone receptor superfamily; FF 3 subtypes (alpha, beta, gamma) XX IN T00836; T3R; mouse, Mus musculus. IN T00837; T3R; chick, Gallus gallus. IN T00838; T3R; human, Homo sapiens. IN T00839; T3R; rat, Rattus norvegicus. IN T00840; T3R; rat, Rattus norvegicus. IN T00854; T3R; monkey, Cercopithecus aethiops. XX BS R02240; RAR$CONS; Quality: 6 XX RN [1] RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado RA J., Pike J. W., Evans R. M. RT Jun-Fos and receptors for vitamins A and D recognize RT a common response element in the human osteocalcin gene RL Cell 61:497-504 (1990). RN [2] RA Glass C. K., Devary O. V., Rosenfeld M. G. RT Multiple cell type-specific proteins differentially RT regulate target sequence recognition by the alpha retinoic acid receptor RL Cell 63:729-738 (1990). RN [3] RA Ellinger-Ziegelbauer H., Dreyer C. RT A retinoic acid receptor expressed in the early development RT of Xenopus laevis RL Genes Dev. 5:94-104 (1991). RN [4] RA Rowe A., Eager N. S. C., Brickell P. M. RT A member of the RXR nuclear receptor family is expressed RT in neural-crest-derived cells of the developing chick RT peripheral nervous system RL Development 111:771-778 (1991). RN [5] RA Vasios G., Mader S., Gold J. D., Leid M., Lutz Y., RA Gaub M.-P., Chambon P., Gudas L. RT The late retinoic acid induction of laminin B1 gene RT transcription involves RAR binding to the responsive element RL EMBO J. 10:1149-1158 (1991). XX // AC T00719 XX ID T00719 XX DT 27.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA RAR-alpha1 XX SY RAR-alpha; retinoic acid receptor alpha; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); 2.1.2.1.1.1. XX SZ 462 AA; 50 kDa (cDNA), 48.5 kDa (SDS) XX SQ MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT SQ IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM SQ VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL SQ TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV SQ EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA SQ GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK SQ VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL SQ DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP XX SC SwissProt #P10276 XX FT 1 88 region A/B FT 88 153 region C, 1st zinc finger (DR box) FT essential for dimerization with RXR-alpha FT 153 200 region D FT 200 462 region E/F FT 242 261 heterodimerization with TRAP or RXR-beta XX SF two splice variants SF alpha1 XX FF member of the steroid hormone receptor superfamily; FF negative regulator of AP-1 responsive genes, dependent FF on the DNA-binding domain of RAR and possibly via FF an unproductive complex with c-Jun; FF 1st zinc finger is the determinant of half-site spacing FF favouring 5 bp spacing XX IN T00836; T3R; mouse, Mus musculus. IN T00837; T3R; chick, Gallus gallus. IN T00838; T3R; human, Homo sapiens. IN T00839; T3R; rat, Rattus norvegicus. IN T00840; T3R; rat, Rattus norvegicus. IN T00841; T3R-alpha; rat, Rattus norvegicus. IN T00854; T3R; monkey, Cercopithecus aethiops. IN T01173; T3R-alpha; mouse, Mus musculus. IN T01331; RXR-alpha; mouse, Mus musculus. IN T01332; RXR-beta; mouse, Mus musculus. IN T01334; RXR-beta; human, Homo sapiens. IN T01345; RXR-alpha; human, Homo sapiens. IN T01349; RXR-beta; rat, Rattus norvegicus. IN T01351; T3R-alpha; chick, Gallus gallus. IN T01355; TRAP; human, Homo sapiens. IN T01359; RXR-alpha; clawed frog, Xenopus laevis. IN T01362; Hp55; human, Homo sapiens. IN T01363; Hp65; human, Homo sapiens. IN T01364; p58; rat, Rattus norvegicus. IN T01365; p45; human, Homo sapiens. IN T01366; RXR-beta2; mouse, Mus musculus. XX BS R03941; AS$RAR_03; Quality: 2 BS R03943; AS$RAR_04; Quality: 2 BS R03944; AS$RAR_05; Quality: 2 BS R03945; AS$RAR_06; Quality: 2 BS R03964; AS$RAR_07; Quality: 2 BS R03965; AS$RAR_08; Quality: 2 BS R03966; AS$RAR_09; Quality: 2 BS R03967; AS$RAR_10; Quality: 2 BS R03968; AS$RAR_11; Quality: 2 BS R03969; AS$RAR_12; Quality: 2 BS R03970; AS$RAR_13; Quality: 2 BS R03971; AS$RAR_14; Quality: 2 BS R03972; AS$RAR_15; Quality: 2 BS R03973; AS$RAR_16; Quality: 2 BS R03974; AS$RAR_17; Quality: 2 BS R03975; AS$RAR_18; Quality: 2 BS R03976; AS$RAR_19; Quality: 2 BS R03977; AS$RAR_20; Quality: 2 BS R03978; AS$RAR_21; Quality: 2 BS R03979; AS$RAR_22; Quality: 2 BS R03981; AS$RAR_23; Quality: 2 BS R01465; AS$TR_01; Quality: 1 BS R03949; AS$TR_09; Quality: 2 BS R03953; AS$TR_13; Quality: 2 BS R00135; HS$APOA1_01; Quality: 6; human, Homo sapiens BS R03942; HS$CAMHC_01; Quality: 6; human, Homo sapiens BS R01187; HS$OC_01; Quality: 1; human, Homo sapiens BS R01321; HS$RARB_01; Quality: 2; human, Homo sapiens BS R03929; HS$RARG_01; Quality: 2; human, Homo sapiens BS R03962; MOUSE$CRBP1_01; Quality: 2; mouse, Mus musculus BS R03963; MOUSE$GFCR_02; Quality: 2; mouse, Mus musculus BS R03928; MOUSE$LB1_01; Quality: 2; mouse, Mus musculus BS R04075; MOUSE$RARA2_01; Quality: 2; mouse, Mus musculus BS R02240; RAR$CONS; Quality: 1 BS R01169; RAT$AMHC_02; Quality: 1; rat, Rattus norvegicus BS R03931; RAT$CRBP2_01; Quality: 2; rat, Rattus norvegicus BS R01690; RAT$PEPCK_15; Quality: 6; rat, Rattus norvegicus XX DR EMBL: X06538; HSRAR(r). DR EMBL: X06614; HSRRA(r). DR SwissProt: P10276; RRA1_HUMAN. DR PIR: A29491; A29491. DR PIR: S07272; S07272. DR Compel: C00072 XX RN [1] RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado RA J., Pike J. W., Evans R. M. RT Jun-Fos and receptors for vitamins A and D recognize RT a common response element in the human osteocalcin gene RL Cell 61:497-504 (1990). RN [2] RA Leid M., Kastner P., Lyons R., Nakshatri H., Saunders RA M., Zacharewski T., Chen J.-Y., Staub A., Garnier RA J.-M., Mader S., Chambon P. RT Purification, cloning, and RXR identity of the HeLa RT cell factor with which RAR or TR heterodimerizes to RT bind target sequences efficiently RL Cell 68:377-395 (1992). RN [3] RA Nicholson R. C., Mader S., Nagpal S., Leid M., Rochette-Egly C., Chambon P. RT Negative regulation of the rat stromelysin gene promoter RT by retinoic acid is mediated by an AP1 binding site RL EMBO J. 9:4443-4454 (1990). RN [4] RA Schuele R., Rangarajan P., Yang N., Kliewer S., Ransone RA L. J., Bolado J., Verma I. M., Evans R. M. RT Retinoic acid is a negative regulator of AP-1-responsive genes RL Proc. Natl. Acad. Sci. USA 88:6092-6096 (1991). RN [5] RA Zhang X. K., Hoffmann B., Tran P. B.-V., Graupner G., Pfahl M. RT Retinoid X receptor is an auxiliary protein for thyroid RT hormone and retinoic acid receptors RL Nature 355:441-446 (1992). RN [6] RA Kliewer S. A., Umesono K., Mangelsdorf D. J., Evans R. M. RT Retinoid X receptor interacts with nuclear receptors RT in retinoic acid, thyroid hormone and vitamin D3 signalling RL Nature 355:446-449 (1992). RN [7] RA Yu V. C., Delsert C., Andersen B., Holloway J. M., RA Devary O. V., Naeaer A. M., Kim S. Y., Boutin J. M., RA Glass C. K., Rosenfeld M. G. RT RXRbeta: a coregulator that enhances binding of retinoic RT acid, thyroid hormone, and vitamin D receptors of RT their cognate response elements RL Cell 67:1251-1266 (1991). RN [8] RA Lucas P. C., Forman B. M., Samuels H. H., Granner D. K. RT Specificity of a retinoic acid response element in RT the phosphoenolpyruvate carboxykinase gene promoter: RT consequences of both retinoic acid and thyroid hormone receptor binding RL Mol. Cell. Biol. 11:5164-5170 (1991). RN [9] RA Rosen E. D., Beninghof E. G., Koenig R. J. RT Dimerization interfaces of thyroid hormone, retinoic RT acid, vitamin D, and retinoid X receptors RL J. Biol. Chem. 268:11534-11541 (1993). RN [10] RA Glass C. K., Devary O. V., Rosenfeld M. G. RT Multiple cell type-specific proteins differentially RT regulate target sequence recognition by the alpha retinoic acid receptor RL Cell 63:729-738 (1990). RN [11] RA Tini M., Otulakowski G., Breitman M. L., Tsui L.-C., Giguere V. RT An everted repeat mediates retinoic acid induction RT of the gammaF-crystallin gene: evidence of a direct RT role for retinoids in lens development RL Genes Dev. 7:295-307 (1993). RN [12] RA Perlman T., Rangarajan P. N., Umesono K., Evans R. M. RT Determinants for selective RAR and TR recognition of direct repeat HREs RL Genes Dev. 7:1411-1422 (1993). RN [13] RA Lucas P. C., O'Brien R. M., Mitchell J. A., Davis RA C. M., Imai E., Forman B. M., Samuels H. H., Granner D. K. RT A retinoic acid response element is part of a pleiotropic RT domain in the phosphoenolpyruvate carboxykinase gene RL Proc. Natl. Acad. Sci. USA 88:2184-2188 (1991). RN [14] RA Yang N., Schuele R., Mangelsdorf D. J., Evans R. M. RT Characterization of DNA binding and retinoic acid RT binding properties of retinoic acid receptor RL Proc. Natl. Acad. Sci. USA 88:3559-3563 (1991). RN [15] RA Petkovich M., Brand N. J., Krust A., Chambon P. RT A human retinoic acid receptor which belongs to the RT family of nuclear receptors RL Nature 330:444-450 (1987). RN [16] RA Giguere V., Ong E. S., Segui P., Evans R. M. RT Identification of a receptor for the morphogen retinoic acid RL Nature 330:624-629 (1987). RN [17] RA Glass C. K., Devary O. V., Rosenfeld M. G. RT Multiple cell type-specific proteins differentially RT regulate target sequence recognition by the alpha retinoic acid receptor RL Cell 63:729-738 (1990). RN [18] RA Ellinger-Ziegelbauer H., Dreyer C. RT A retinoic acid receptor expressed in the early development RT of Xenopus laevis RL Genes Dev. 5:94-104 (1991). RN [19] RA Rowe A., Eager N. S. C., Brickell P. M. RT A member of the RXR nuclear receptor family is expressed RT in neural-crest-derived cells of the developing chick RT peripheral nervous system RL Development 111:771-778 (1991). RN [20] RA Vasios G., Mader S., Gold J. D., Leid M., Lutz Y., RA Gaub M.-P., Chambon P., Gudas L. RT The late retinoic acid induction of laminin B1 gene RT transcription involves RAR binding to the responsive element RL EMBO J. 10:1149-1158 (1991). XX // AC T00720 XX ID T00720 XX DT 27.01.93 (created); hse. DT 10.01.96 (updated); hiwi. XX FA RAR-gamma XX SY retinoic acid receptor gamma; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); 2.1.2.1.3. XX SZ 443-454 AA; 49.3-50.3 kDa (cDNA), 48.5 kDa (SDS) XX SF two N-terminally differing splice variants (RAR-gamma1 SF and -gamma2) of 454 and 443 AA XX FF member of the steroid hormone receptor superfamily; FF 3 subtypes (alpha, beta, gamma) XX IN T00836; T3R; mouse, Mus musculus. IN T00837; T3R; chick, Gallus gallus. IN T00838; T3R; human, Homo sapiens. IN T00839; T3R; rat, Rattus norvegicus. IN T00840; T3R; rat, Rattus norvegicus. IN T00854; T3R; monkey, Cercopithecus aethiops. IN T01331; RXR-alpha; mouse, Mus musculus. IN T01332; RXR-beta; mouse, Mus musculus. IN T01333; RXR-gamma; mouse, Mus musculus. IN T01334; RXR-beta; human, Homo sapiens. IN T01345; RXR-alpha; human, Homo sapiens. XX BS R03930; AS$RAR_01; Quality: 2 BS R01465; AS$TR_01; Quality: 6 BS R01321; HS$RARB_01; Quality: 2; human, Homo sapiens BS R03929; HS$RARG_01; Quality: 2; human, Homo sapiens BS R03928; MOUSE$LB1_01; Quality: 2; mouse, Mus musculus BS R02240; RAR$CONS; Quality: 1 XX DR EMBL: M24857; HSHRARC(r). DR EMBL: M57707; HSRARG(r). DR EMBL: M32074; HSRARG2(r). DR EMBL: M38258; HSRARGA(r). DR SwissProt: P13631; RRG1_HUMAN. DR SwissProt: P22932; RRG2_HUMAN. DR PIR: A33903; A33903. DR PIR: A35573; A35573. DR Compel: C00072 XX RN [1] RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado RA J., Pike J. W., Evans R. M. RT Jun-Fos and receptors for vitamins A and D recognize RT a common response element in the human osteocalcin gene RL Cell 61:497-504 (1990). RN [2] RA Glass C. K., Devary O. V., Rosenfeld M. G. RT Multiple cell type-specific proteins differentially RT regulate target sequence recognition by the alpha retinoic acid receptor RL Cell 63:729-738 (1990). RN [3] RA Ellinger-Ziegelbauer H., Dreyer C. RT A retinoic acid receptor expressed in the early development RT of Xenopus laevis RL Genes Dev. 5:94-104 (1991). RN [4] RA Rowe A., Eager N. S. C., Brickell P. M. RT A member of the RXR nuclear receptor family is expressed RT in neural-crest-derived cells of the developing chick RT peripheral nervous system RL Development 111:771-778 (1991). RN [5] RA Vasios G., Mader S., Gold J. D., Leid M., Lutz Y., RA Gaub M.-P., Chambon P., Gudas L. RT The late retinoic acid induction of laminin B1 gene RT transcription involves RAR binding to the responsive element RL EMBO J. 10:1149-1158 (1991). XX // AC T00721 XX ID T00721 XX DT 14.12.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA RAR-beta XX SY retinoic acid receptor beta; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); . XX SZ 448 AA; 50.3 kDa (cDNA) XX SQ MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTS SQ SEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRD SQ KNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDL SQ TEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLP SQ GFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD SQ LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRR SQ PSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSS SQ SGNTAEHSPSISPSSVENSGVSQSPLVQ XX SC SwissProt #P10826 XX SF 3 N-terminally differing splice variants XX FF negative regulation of AP-1 responsive genes XX IN T01331; RXR-alpha; mouse, Mus musculus. IN T01334; RXR-beta; human, Homo sapiens. IN T01345; RXR-alpha; human, Homo sapiens. IN T01359; RXR-alpha; clawed frog, Xenopus laevis. XX BS R03933; AS$RAR_02; Quality: 2 BS R01465; AS$TR_01; Quality: 6 BS R03017; HS$ADH3_01; Quality: 1; human, Homo sapiens BS R00135; HS$APOA1_01; Quality: 6; human, Homo sapiens BS R01321; HS$RARB_01; Quality: 1; human, Homo sapiens BS R03929; HS$RARG_01; Quality: 2; human, Homo sapiens BS R02856; MOUSE$CHF_01; Quality: 1; mouse, Mus musculus BS R03928; MOUSE$LB1_01; Quality: 2; mouse, Mus musculus BS R02240; RAR$CONS; Quality: 1 BS R03932; RAT$CRBP1_01; Quality: 2; rat, Rattus norvegicus BS R03931; RAT$CRBP2_01; Quality: 2; rat, Rattus norvegicus XX DR EMBL: Y00291; HSHAPRA(r). DR EMBL: X07282; HSRARE(r). DR SwissProt: P10826; RRB2_HUMAN. DR PIR: A29492; A29492. DR PIR: S02827; S02827. DR Compel: C00072 XX RN [1] RA Zhang X.-K., Lehmann J., Hoffmann B., Dawson M. I., RA Cameron J., Graupner G., Hermann T., Tran P., Pfahl M. RT Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid RL Nature 358:587-591 (1992). RN [2] RA Leid M., Kastner P., Lyons R., Nakshatri H., Saunders RA M., Zacharewski T., Chen J.-Y., Staub A., Garnier RA J.-M., Mader S., Chambon P. RT Purification, cloning, and RXR identity of the HeLa RT cell factor with which RAR or TR heterodimerizes to RT bind target sequences efficiently RL Cell 68:377-395 (1992). RN [3] RA Nicholson R. C., Mader S., Nagpal S., Leid M., Rochette-Egly C., Chambon P. RT Negative regulation of the rat stromelysin gene promoter RT by retinoic acid is mediated by an AP1 binding site RL EMBO J. 9:4443-4454 (1990). RN [4] RA Schuele R., Rangarajan P., Yang N., Kliewer S., Ransone RA L. J., Bolado J., Verma I. M., Evans R. M. RT Retinoic acid is a negative regulator of AP-1-responsive genes RL Proc. Natl. Acad. Sci. USA 88:6092-6096 (1991). RN [5] RA Zhang X. K., Hoffmann B., Tran P. B.-V., Graupner G., Pfahl M. RT Retinoid X receptor is an auxiliary protein for thyroid RT hormone and retinoic acid receptors RL Nature 355:441-446 (1992). RN [6] RA Sucov H. M., Murakami K. K., Evans R. M. RT Characterization of an autoregulated response element RT in the mouse retinoic acid receptor type beta gene RL Proc. Natl. Acad. Sci. USA 87:5392-5396 (1990). RN [7] RA Duester G., Shean M. L., McBride M. S., Stewart M. J. RT Retinoic acid response element in the human alcohol RT dehydrogenase gene ADH3: implications for regulation RT of retinoic acid synthesis RL Mol. Cell. Biol. 11:1638-1646 (1991). XX // AC T00722 XX ID T00722 XX DT 14.04.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Rb XX SY retinoblastoma tumor suppressor protein; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 0.5.1.0.1. XX SZ 928 AA XX SQ MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTAL SQ CQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTEL SQ QKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS SQ ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYK SQ TAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFM SQ NSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS SQ NLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVK SQ DIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDN SQ IFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEG SQ NLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNH SQ TAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYL SQ RLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLK SQ FKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLS SQ PIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFG SQ TSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQK SQ LAEMTSTRTRMQKQKMNDSMDTSNKEEK XX SC SwissProt #P06400 XX FT 393 573 homology to TBP(167-317) FT 645 772 homology to TFIIB(117-270) XX FF tumor suppressor XX IN T00140; c-Myc; human, Homo sapiens. IN T00167; CRE-BP1; human, Homo sapiens. IN T00221; E2F; human, Homo sapiens. IN T00702; PU.1; mouse, Mus musculus. IN T00703; Pu.1; chick, Gallus gallus. IN T01113; Elf-1; human, Homo sapiens. IN T01212; Id2; human, Homo sapiens. IN T01489; RBP60; human, Homo sapiens. IN T01542; E2F-1; human, Homo sapiens. IN T01544; E2F-2; human, Homo sapiens. IN T01545; E2F-3; human, Homo sapiens. IN T02068; PU.1; human, Homo sapiens. XX BS R00326; AD$E2AE1_12; Quality: 2; adenovirus XX DR EMBL: X16439; HSRB1G(g). DR EMBL: M33647; HSRB1RA(r). DR EMBL: M15400; HSRBS(r). DR EMBL: M28419; HSRBSA(r). DR SwissProt: P06400; RB_HUMAN. DR PIR: A39947; A39947. DR PIR: JS0276; RBHU. XX RN [1] RA Hagemeier C., Bannister A. J., Cook A., Kouzarides T. RT The activation domain of transcription factor PU.1 RT binds the retinoblastoma (RB) protein and the transcription RT factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB RL Proc. Natl. Acad. Sci. USA 90:1580-1584 (1993). XX // AC T00723 XX ID T00723 XX DT 15.10.92 (created); ewi. XX FA RC1 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX BS R00259; Y$CYC1_06; Quality: 4; yeast, Saccharomyces cerevisiae BS R00261; Y$CYC1_08; Quality: 4; yeast, Saccharomyces cerevisiae XX RN [1] RA Arcangioli B., Lescure B. RT Identification of proteins involved in the regulation RT of yeast iso-1-cytochrome C expression by oxygen RL EMBO J. 4:2627-2633 (1985). XX // AC T00724 XX ID T00724 XX DT 15.10.92 (created); ewi. DT 19.02.94 (updated); dhawale & lane. XX FA RC2 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX FF mutual exclusive DNA binding with HAP1 XX BS R00258; Y$CYC1_05; Quality: 4; yeast, Saccharomyces cerevisiae BS R00259; Y$CYC1_06; Quality: 4; yeast, Saccharomyces cerevisiae BS R00260; Y$CYC1_07; Quality: 4; yeast, Saccharomyces cerevisiae BS R00261; Y$CYC1_08; Quality: 4; yeast, Saccharomyces cerevisiae XX RN [1] RA Pfeifer K., Arcangioli B., Guarente L. RT Yeast HAP1 activator competes with the factor RC2 RT for binding to the upstream activation site UAS1 of the CYC1 gene RL Cell 49:9-18 (1987). RN [2] RA Sousa R., Arcangioli B. RT A point mutation in the CYC1 UAS1 creates a new combination RT of regulatory elements that activate transcription synergistically RL EMBO J. 8:1801-1808 (1989). RN [3] RA Arcangioli B., Lescure B. RT Identification of proteins involved in the regulation RT of yeast iso-1-cytochrome C expression by oxygen RL EMBO J. 4:2627-2633 (1985). XX // AC T00725 XX ID T00725 XX DT 20.11.92 (created); ewi. DT 22.08.96 (updated); ewi. XX FA REB1 XX SY GRF2; RBP1; Reb1p; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0022; trp; 3.5.1.2.2. XX SZ 809 AA; 92.1 kDa (cDNA); 125 kDa (SDS) XX SQ MPSGHNDKNANQESVEEAVLKYVGVGLDHQNHDPQLHTKDLENKHSKKQNIVESSSDVDV SQ NNNDDSNRNEDNNDDSENISALNANESSSNVDHANSNEQHNAVMDWYLRQTAHNQQDDED SQ DENNNNTDNGNDSNNHFSQSDIVVDDDDDKNKKDAGVGVDDDHQSMAMAAVAAAYTLSKN SQ NNNNNSIANDSNSRKRQHDNGNNHENSQKKRKNNNDDDDRQIGNVDPELTTLGDADDNDT SQ NNDVIDRDQLVHKAIIDADSITQHPDFQQYLNTAADTDDNEKLKHIKDHLMRTHGLNHQN SQ KNHNDDTDDLSNSTKQYSELQKDSMLDSSLNKSRNYMEVLPKVISQDTQPHQQKSPSHDN SQ EAGSVDNSEISQLLQSAATKASSLVSLSSSSATPSTSRSNNSKAFDKAEDAALERFINEY SQ EAIERLTRQQVCERIWSSDRPKDNFWNNIYKVLPYRSSSSIYKHMRRKYHIFEQRGKWTA SQ EEEQELAKLCAEKEGQWAEIGKTLGRMPEDCRDRWRNYVKCGTNRASNRWSVEEEELLKK SQ VISDMLEEAQQQQSQLHPNLLEEEQHLLQDDQNDHRNNDEDDDDTASAAAARAVVFKNNN SQ NFFNKSSKMMTMLLRSCAAASSSLGENKDEDKPHESLGIQLDDNSQNSMVPAPSATSTHS SQ KSLSNTIRRHNNKLRKSLMGNGKLDFKDIINWTIVSERMGGTRSRIQCRYKWNKLVKREA SQ IAKIQTVKDDDMLWIFEKLRDLGITEDSQVDWDELAALKPGMKLNGLELKLCYERMKKKV SQ KGYKQKSINEISKELVDYFSSNISMKTEN XX SC edited SwissProt #P21538 according to [x256] XX FT 470 519 Myb-homology region FT 478 515 tryptophan cluster (W-X18-W-X17-W) XX SF several acidic or asparagine-rich regions XX FF involved in pol II and pol I transcription, repressor; FF functionally interchangeable with K. lactis Reb1p [1]; XX BS R04026; GRF2$CONS_01; Quality: 6 BS R03754; KLULA$REB1_01; Quality: 6; yeast, Kluyveromyces lactis BS R00020; Y$ACT1_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R00206; Y$CDC9_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R00489; Y$GAL1_04; Quality: 1; yeast, Saccharomyces cerevisiae BS R01304; Y$RAP_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R02406; Y$REB1_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R03753; Y$RRNA_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R04027; Y$RRNA_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R01467; Y$TRP1_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R01466; Y$TRP5_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R01600; Y$X40_01; Quality: 1; yeast, Saccharomyces cerevisiae BS R01601; Y$Y30_01; Quality: 1; yeast, Saccharomyces cerevisiae XX DR EMBL: M58728; SCREB1(g). DR SwissProt: P21538; REB1_YEAST. DR PIR: A35924; A35924. XX RN [1] RA Morrow B. E., Ju Q., Warner J. R. RT A bipartite DNA-binding domain in yeast Reb1p RL Mol. Cell. Biol. 13:1173-1182 (1993). RN [2] RA Ju Q., Morrow B. E., Warner J. R. RT REB1, a yeast DNA-binding protein with many targets, RT is essential for cell growth and bears some resemblance to the oncogene myb RL Mol. Cell. Biol. 10:5226-5234 (1990). XX // AC T00726 XX ID T00726 XX DT 13.11.92 (created); ewi. XX FA repressor of CAR1 expression XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX FF represses CAR1 expression XX MX M00014; F$REPCAR1_01 XX BS R02329; Y$ARG4_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02319; Y$CAR1_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02326; Y$CAR2_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02324; Y$CTA1_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02331; Y$CTT1_02; Quality: 4; yeast, Saccharomyces cerevisiae BS R02328; Y$CYB2_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02330; Y$ENO1_03; Quality: 4; yeast, Saccharomyces cerevisiae BS R02325; Y$G3PDH_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02332; Y$HSF1_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02327; Y$ILV2_02; Quality: 4; yeast, Saccharomyces cerevisiae BS R02320; Y$MES1_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02323; Y$PYK1_02; Quality: 4; yeast, Saccharomyces cerevisiae BS R02321; Y$SSA1_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R02322; Y$TOP1_01; Quality: 4; yeast, Saccharomyces cerevisiae XX RN [1] RA Luche R. M., Sumrada R., Cooper T. G. RT A cis-acting element present in multiple genes serves RT as a repressor protein binding site for the yeast CAR1 gene RL Mol. Cell. Biol. 10:3884-3895 (1990). XX // AC T00727 XX ID T00727 XX DT 09.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA REX-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; . XX SZ 288 AA XX SQ MNEQKMNEQMKKTAKTSGQKGPGGRALDRLTLKQDEARPVQNTRVEAPRVTYTIRDESEI SQ SPETEEDGFPDGYLECIIRGEFSEPILEEDFLFKSFESLEEVEQNLSRQVLEASSLLESS SQ LEYMTKGTKQEKTEVTQETPPLRVGASSLLAGGPAEKPEGGVYCGVLSMLECPQAGCKKK SQ LRGKTALRKHMLVHGPRRHVCAECGKAFTESSKLKRHFLVHTGEKPYQCTFEGCGKRFSL SQ DFNLRTHIRIHTGERRFVCPFDGCEKSFIQSNNQKIHILTHAKAGKKC XX SC SwissProt #P22227 XX SF 4 zinc finger motifs XX CP undifferentiated stem cells XX FF in F9 cells rapidly reduced upon differentiation (induced by RA) XX DR EMBL: M97812; MMREX03(g). DR EMBL: M28382; MMREX1(r). DR SwissProt: P22227; REX1_MOUSE. DR PIR: A33828; A33828. XX RN [1] RA Hosler B. A., LaRosa G. J., Grippo J. F., Gudas L. J. RT Expression of REX-1, a gene containing zinc finger RT motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells RL Mol. Cell. Biol. 9:5623-5629 (1989). XX // AC T00728 XX ID T00728 XX DT 15.10.92 (created); ewi. DT 15.02.96 (updated); ewi. XX FA RFX XX SY RF-X; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 1.5.1. XX CP ubiquitous XX FF activator [3]; FF acts on X boxes of MHC class II alpha-chain gene promoters [1], [4], [6]; FF different from NF-X; FF it cooperatively binds to the X-Y-box pattern of MHC FF gene promoters with NF-Y [2]; XX IN T00728; RFX; human, Homo sapiens. XX BS R02384; HS$M2DPA_01; Quality: 6; human, Homo sapiens BS R03695; HS$M2DQB_02; Quality: 6; human, Homo sapiens BS R01087; HS$M2DRA_02; Quality: 6; human, Homo sapiens BS R01940; MOUSE$M2IAA_06; Quality: 6; mouse, Mus musculus BS R02241; RFX$CONS; Quality: 6 XX DR Compel: C00106 XX RN [1] RA Reith W., Satola S., Herrero Sanchez C., Amaldi I., RA Lisowska-Grospierre B., Griscelli C., Hadam M. R., Mach B. RT Congenital Immunodeficiency with a Regulatory Defect RT in MHC Class II Gene Expression Lacks a Specific HLA-DR RT Promoter Binding Protein, RF-X RL Cell 53:897-906 (1988). RN [2] RA Reith W., Siegrist C. A., Durand B., Barras E., Mach B. RT Function of major histocompatibility complex class RT II promoters requires cooperative binding between factors RFX and NF-Y RL Proc. Natl. Acad. Sci. USA 91:554-558 (1994). RN [3] RA Siegrist C. A., Durand B., Emery P., David E., Hearing P., Mach B., Reith W. RT RFX1 is identical to enhancer factor C and functions RT as a transactivator of the hepatitis B virus enhancer RL Proc. Natl. Acad. Sci. USA 90:6375-6384 (1993). RN [4] RA Reith W., Barras E., Satola S., Kobr M., Reinhardt RA D., Sanchez C. H., Mach B. RT Cloning of the major histocompatibility complex class RT II promoter binding protein affected in a hereditary RT defect in class II gene regulation RL Proc. Natl. Acad. Sci. USA 86:4200-4204 (1989). RN [5] RA Hasegawa S. L., Sloan J. H., Reith W., Mach B., Boss J. M. RT Regulatory factor-X binding to mutant HLA-DRA promoter sequences RL Nucleic Acids Res. 19:1243-1248 (1991). RN [6] RA Kobr M., Reith W., Herrero-Sanchez C., Mach B. RT Two DNA-binding proteins discriminate between the RT promoters of different members of the major histocompatibility RT complex class II multigene family RL Mol. Cell. Biol. 10:965-971 (1990). XX // AC T00729 XX ID T00729 XX DT 15.10.92 (created); ewi. XX FA RF-Y XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 40-54 kDa? XX BS R01088; HS$M2DRA_03; Quality: 6; human, Homo sapiens XX RN [1] RA Reith W., Satola S., Herrero Sanchez C., Amaldi I., RA Lisowska-Grospierre B., Griscelli C., Hadam M. R., Mach B. RT Congenital Immunodeficiency with a Regulatory Defect RT in MHC Class II Gene Expression Lacks a Specific HLA-DR RT Promoter Binding Protein, RF-X RL Cell 53:897-906 (1988). RN [2] RA Sherman P. A., Basta P. V., Moore T. L., Brown A. M., Ting J. P.-Y. RT Class II Box Consensus Sequences in the HLA-DRalpha RT Gene: Transcriptional Function and Interaction with Nuclear Proteins RL Mol. Cell. Biol. 9:50-56 (1989). XX // AC T00730 XX ID T00730 XX DT 09.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA RGM1 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 211 AA XX SQ MRGKQPKRNKDNASVKRNYRCVGYPDCNMSFNRTEHLARHIRKHTGEKPFQCNICLKFFS SQ RIDNLRQHQSSVHSDVDLMSLRRLQQSANSTANDPNATRMFPQLRPYGIVVQPVPVPYNL SQ PISTPASPQDTISLYAPPYFPHPMPSAPIPLPHQPPPLPIYSYMQPLFLNHTPIQNHNIV SQ ELPPDSSDTPASPSKVQSFDQAKDASPNAKK XX SC SwissProt #Q00453 XX SF proline-rich region XX FF repressor; FF may control cell growth XX DR EMBL: X59861; SCRGM1(g). DR SwissProt: Q00453; RGM1_YEAST. DR PIR: S17249; S17249. XX RN [1] RA Estruch F. RT The yeast putative transcriptional repressor RGM1 RT is a proline-rich zinc finger protein RL Nucleic Acids Res. 19:4873-4877 (1991). XX // AC T00731 XX ID T00731 XX DT 09.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA RME1 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0001; CH; 2.3.2.3.5. XX SZ 300 AA XX SQ MSPCYGQNSAIAKGSWNREVLQEVQPIYHWHDFGQNMKEYSASPLEGDSSLPSSLPSSTE SQ DCLLLSLENTITVIAGNQRQAYDSTSSTEEGTAPQLRPDEIADSTHCITSLVDPEFRDLI SQ NYGRQKGANPVFIESNTTEQSHSQCILGYPQKSHVAQLYHDPKVLSTISEGQTKRGSYHC SQ SHCSEKFATLVEFAAHLDEFNLERPCKCPIEQCPWKILGFQQATGLRRHCASQHIGELDI SQ EMEKSLNLKVEKYPGLNCPFPICQKTFRRKDAYKRHVAMVHNNADSRFNKRLKKILNNTK XX SC SwissProt #P32338 XX SF 3 zinc finger motifs XX FF repressor of meiotic genes; FF repressed by a1-alpha2 XX BS R03863; Y$IME1_01; Quality: 1; yeast, Saccharomyces cerevisiae XX DR EMBL: M76447; SCZFP(g). DR SwissProt: P32338; RME1_YEAST. DR PIR: A41517; A41517. XX RN [1] RA Covitz P. A., Mitchell A. P. RT Repression by the yeast meiotic inhibitor RME1 RL Genes Dev. 7:1598-1608 (1993). RN [2] RA Covitz P. A., Herskowitz I., Mitchell A. P. RT The yeast RME1 gene encodes a putative zinc finger RT protein that is directly repressed by a1-alpha2 RL Genes Dev. 5:1982-1989 (1991). XX // AC T00732 XX ID T00732 XX DT 01.12.92 (created); ewi. DT 29.01.97 (updated); ewi. XX FA Ro XX SY Rough; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0006; homeo; 3.1.1.0.9. XX SZ 350 AA; 39.5 kDa (gene) XX SQ MQRHKVEIGSPDGSPGIKRSDSLDPIANTTILSVPQRPSSPRQFFERLYGHLETRSSENG SQ EIDVGTHAHKPPPCDTPYHSDGGSVSSPDISISDERTSLAAYPAYDFYGHAKDYPQHPSQ SQ QHQQHHHHHHHPPQLVHQKLSYVSPPPAIAAGGAANPVLPHAFPAGFPSDPHFSAGFSAF SQ LARRRRKEGRQRRQRTTFSTEQTLRLEVEFHRNEYLSRSRRFELAETLRLTETQIKIWFQ SQ NRRAKDKRIEKAQIDQHYRNFVVANGFMSSIMGQAATTMPPGGVTGGVAVGVGLNYYAAA SQ ATPTALPKDNTQDANFIDIDDQFQRQQQQKQQQQQQQQRRRETTTPINIC XX SC SwissProt #P10181 XX FT 190 250 homeo domain FT 322 338 glutamine-rich region (14/17) XX FF required for normal development of eye imaginal discs; FF involved in producing signals in photoreceptors R2 FF and R5 required for specification of neighbouring FF cells to develop ommatidia [2]; XX DR EMBL: X12528; DMROHOB(g). DR EMBL: M23629; DMROUGH(g). DR SwissProt: P10181; HMRO_DROME. DR PIR: A30046; A30046. DR PIR: S03168; S03168. DR Flybase: FBgn0003267; ro. XX RN [1] RA Saint R., Kalionis B., Lockett T. J., Elizur A. RT Pattern formation in the developing eye of Drosophila RT melanogaster is regulated by the homoeo-box gene, rough RL Nature 334:151-154 (1988). RN [2] RA Tomlinson A., Kimmel B. E., Rubin G. M. RT rough, a Drosophila homeobox gene required in photoreceptors RT R2 and R5 for inductive interactions in the developing eye RL Cell 55:771-784 (1988). XX // AC T00733 XX ID T00733 XX DT 17.11.92 (created); ewi. XX FA RPF1 XX SY RPF-1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 50 kDa; 90 kDa (SDS) XX FF binds to an element of the EGF receptor gene that FF mediates responses to EGF, PMA and cAMP; FF different from AP-2 XX BS R00385; HS$EGFR_12; Quality: 6; human, Homo sapiens XX RN [1] RA Hudson L. G., Thompson K. L., Xu J., Gill G. N. RT Identification and characterization of a regulated RT promoter element in the epidermal growth factor receptor gene RL Proc. Natl. Acad. Sci. USA 87:7536-7540 (1990). XX // AC T00734 XX ID T00734 XX DT 27.01.93 (created); hse. XX FA RVF XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 60 kDa (SDS) XX FF acts on neu gene promoter XX BS R03055; RAT$NEU_02; Quality: 6; rat, Rattus norvegicus BS R02242; RVF$CONS; Quality: 6 XX RN [1] RA Yan D.-H., Hung M.-C. RT Identification and characterization of a novel enhancer RT for the rat neu promoter RL Mol. Cell. Biol. 11:1875-1882 (1991). XX // AC T00735 XX ID T00735 XX DT 27.01.93 (created); hse. XX FA RVF XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 60 kDa (SDS) XX FF acts on neu gene promoter XX BS R02242; RVF$CONS; Quality: 6 XX RN [1] RA Yan D.-H., Hung M.-C. RT Identification and characterization of a novel enhancer RT for the rat neu promoter RL Mol. Cell. Biol. 11:1875-1882 (1991). XX // AC T00736 XX ID T00736 XX DT 27.01.93 (created); hse. XX FA RVF XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 60 kDa (SDS) XX FF acts on neu gene promoter XX BS R02242; RVF$CONS; Quality: 6 XX RN [1] RA Yan D.-H., Hung M.-C. RT Identification and characterization of a novel enhancer RT for the rat neu promoter RL Mol. Cell. Biol. 11:1875-1882 (1991). XX // AC T00737 XX ID T00737 XX DT 27.10.92 (created); ewi. DT 21.05.97 (updated); ewi. XX FA SAP-1a XX SY SAP-1; SRF accessory protein 1; SRF accessory protein 1a; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO TCF XX CL C0016; ETS; 3.5.2.0.6.1. XX SZ 431 AA; 46.8 kDa (cDNA); 58 kDa (SDS) XX SQ MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLS SQ RALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDV SQ ENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKS SQ PQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPT SQ SASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEP SQ KDQDSVLLEKDKVNNSSRSKKPKGLGLAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQ SQ TPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPST SQ PGPFSPDLQKT XX SC SwissProt #P28324 XX FT 2 85 ETS domain (TCF homology box A) FT 352 402 Box C FT 361 431 replaced by 361-405 in SAP-1b FT 381 381 Serin-phosphorylation by MAP kinase(-like) activity [3]; FT 8 45 tryptophan cluster (W-X17-W-X18-W) FT 136 156 Box B, essential for ternary complex formation XX SF revised sequence [2]; SF a splice variant is SAP-1b SF three regions os similarity with Elk-1, one of them SF (box C) largely truncated in SAP-1b [2]; SF no intrinsic DNA-binding, but contacts DNA when incorporated SF in a ternary complex with SRF at an SRE [2]; SF ternary complex formation with SRE and SRF is independent SF of orientation and distance to the SRF site [2], [1]; SF box C may reduce ternary complex formation [2]; SF phosphorylation-dependent activation of SAP-1a involves SF Ser-381, Ser-387, Thr-420 and Ser-425 [3]; XX FF cooperates with SRF in activating transcription from certain SREs [2]; FF activating phosphorylation by ERK2 in vitro and most likely in vivo [3]; XX IN T00672; p67; human, Homo sapiens. IN T00761; SRF; chick, Gallus gallus. IN T00762; SRF; cat, Felis catus. IN T00763; SRF; clawed frog, Xenopus laevis. IN T00764; SRF; human, Homo sapiens. IN T00765; SRF; mouse, Mus musculus. IN T00766; SRF; rat, Rattus norvegicus. XX BS R03598; AS$ELK1_07; Quality: 6 BS R03600; AS$ELK1_09; Quality: 6 BS R03603; AS$ELK1_12; Quality: 6 BS R03604; AS$ELK1_13; Quality: 6 BS R00040; HS$BAC_04; Quality: 6; human, Homo sapiens BS R00466; HS$CFOS_09; Quality: 2; human, Homo sapiens BS R00961; MOUSE$KROX_01; Quality: 6; mouse, Mus musculus BS R03582; XENLA$CFOS_01; Quality: 6; clawed frog, Xenopus laevis XX DR EMBL: M85165; HSSERREFB(r). DR SwissProt: P28324; SAPA_HUMAN. DR PIR: B42093; B42093. DR Compel: C00022 XX RN [1] RA Treisman R., Marais R., Wynne J. RT Spatial flexibility in ternary complexes between SRF RT and its accessory proteins RL EMBO J. 11:4631-4640 (1992). RN [2] RA Dalton S., Treisman R. RT Characterization of SAP-1, a protein recruited by RT serum response factor to the c-fos serum response element RL Cell 76:411-411 (1994). RN [3] RA Price M. A., Rogers A. E., Treisman R. RT Comparative analysis of the ternary complex factors RT Elk-1, SAP-1a and SAP-2 (ERP/NET) RL EMBO J. 14:2589-2601 (1995). RN [4] RA Shaw P. E., Schroeter H., Nordheim A. RT The Ability of a Ternary Complex to Form Over the RT Serum Response Element Correlates with Serum Inducibility RT of the Human c-fos Promoter RL Cell 56:563-572 (1989). RN [5] RA Schroeter H., Mueller C. G. F., Meese K., Nordheim A. RT Synergism in ternary complex formation between the RT dimeric glycoprotein p67SRF, polypeptide p62TCF and RT the c-fos serum response element RL EMBO J. 9:1123-1130 (1990). RN [6] RA Dalton S., Treisman R. RT Characterization of SAP-1, a protein recruited by RT serum response factor to the c-fos serum response element RL Cell 68:597-612 (1992). XX // AC T00738 XX ID T00738 XX DT 02.12.92 (created); ewi. XX FA SBF XX SY Sph motif binding factor; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX BS R02596; CHICK$U1SN_02; Quality: 2; chick, Gallus gallus BS R01507; CHICK$U4BSN_01; Quality: 2; chick, Gallus gallus XX RN [1] RA Roebuck K. A., Szeto D. P., Green K. P., Fan Q. N., Stumph W. E. RT Octamer and SPH Motifs in the U1 Enhancer Cooperate RT To Activate U1 RNA Gene Expression RL Mol. Cell. Biol. 10:341-352 (1990). XX // AC T00739 XX ID T00739 XX DT 12.03.93 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA SBF-1 XX OS french bean, Phaseolus vulgaris OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC rosidae; fabales; fabaceae XX SZ 95 kDa (SDS) XX SF phosphorylation XX FF silencer-binding factor; FF phosphorylation required for DNA-binding; FF closely related to GT-1 XX MX M00149; P$SBF1_01 XX BS R01318; PEA$RS3A_03; Quality: 6; pea, Pisum sativum BS R03077; PV$CHS_01; Quality: 6; french bean, Phaseolus vulgaris BS R03078; PV$CHS_02; Quality: 6; french bean, Phaseolus vulgaris BS R03079; PV$CHS_03; Quality: 6; french bean, Phaseolus vulgaris BS R03651; SBF1$CONS_01; Quality: 6 XX RN [1] RA Lawton M. A., Dean S. M., Dron M., Kooter J. M., Kragh RA D. M., Harrison M. J., Yu L., Tanguay L., Dixon R. A., Lamb C. J. RT Silencer region of a chalcone synthase promoter contains RT multiple binding sites for a factor, SBF-1, closely related to GT-1 RL Plant Mol. Biol. 16:235-249 (1991). RN [2] RA Harrison M. J., Lawton M. A., Lamb C. J., Dixon R. A. RT Characterization of a nuclear protein that binds to RT three elements within the silencer region of a bean RT chalcone synthase gene promoter RL Proc. Natl. Acad. Sci. USA 88:2515-2519 (1991). XX // AC T00740 XX ID T00740 XX DT 15.10.92 (created); ewi. XX FA SCD1/BP XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01840; MOUSE$SCD1_01; Quality: 6; mouse, Mus musculus XX RN [1] RA Christy R. J., Yang V. W., Ntambi J. M., Geiman D. RA E., Landschulz W. H., Friedman A. D., Nakabeppu Y., Kelly T. J., Lane M. D. RT Differentiation-induced gene expression in 3T3-L1 RT preadipocytes: CCAAT/ enhancer binding protein interacts RT with and activates the promoters of two adipocyte-specific genes RL Genes Dev. 3:1323-1335 (1989). XX // AC T00741 XX ID T00741 XX DT 15.10.92 (created); ewi. XX FA SCM-inducible factor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX RN [1] RA Hayes T. E., Kitchen A. M., Cochran B. H. RT Inducible binding of a factor to the c-fos regulatory region RL Proc. Natl. Acad. Sci. USA 84:1272-1276 (1987). XX // AC T00742 XX ID T00742 XX DT 10.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Sdc-1 XX OS Caenorhabditis elegans OC eukaryota; animalia; eumetazoa; nematoda; secernentea; OC rhabditia; rhabditida; rhabditina; rhabditoidea; rhabditidae XX CL C0001; CH; 2.3.2.2.11. XX SZ 1203 AA XX SQ MSDEEDIDESFEIEEVGISITDARGNSLKAQQIAGKERNLDPEADDLEVVVNFYEAGDGT SQ FQLQLPKLTAVKPVDKVNDVLDFINFDKKVCDGIHSSIKLVSQRDQTGPAPFPKHKLTCA SQ HCDWSFDNVMKLVRHRGVHKNVGVYMCQVCLTLFGHTYNLFMHWRTSCSQTSTTATDIEI SQ QLQKAETPYLHRNVLNVLGSLNRASQYYCTGGYVFLPSDWCITNKEIVMEKDHMSSCHLC SQ HLPVPNKFLEAHGNVHRGRFRIDGRIYGDYFCHICGTVFIEQDNLFKHWRLHCEEVIAYT SQ PVDQYLSNTELATLAWLVLQTTISQADIECLRVSSSLITEKLAKEHAERHGIANSMHKYY SQ HFPQEIWPLKTFVNLDLVNDAIPISGENSFKIKDPKRPVHIMNLLATACPGFYATGKTFN SQ MICSTKKSESDTKKVYRVILRYTTEGSVIQSYDFTARSFPKLRVDSETPEGVFSHPLADF SQ NVESNEAIVCHKCDSKKLTITFSTEVRLKYHLLRHSESRKDGYHCAICKIIVYNRSHEEH SQ WINDCIPLQKLYRDQKDRECFDAEFAAKCASIIKKLRIRTLIRWKERANEDWVETKQTPD SQ RIGEDFAIKFQVGTTALKTLMAGLEEHYKNAQARHEAYKYSEENFLPPLSTPVVVCFHCG SQ TRCHYTLLHDHLDYCHYWPRNKRLVNEEFHKWKKNGCRNTWRVMKSVAEAMQIEVPFISE SQ EQYSKILDYHTYFCNDTRYKVQDSINNWNDCSTIRDVDLSEKLSVAEIVQKGEDSVMAPE SQ PDIIKNVYFPSARIITDNMLLRMTEINLNDVVQRDPITKEELTGKFKEVQDEQDAILFGD SQ YRAVLRSKGIMVNSISDFVAPPDELAKAKASQESAGQESVDHRNRREREFIQQYMGKDLA SQ LEAAARENGRLVEVDEEAEDYELTPKELNARRLVERNRHREMCFSRCEHGEYDYEKFKAR SQ QVPINPAKMKERKYLTRVVHESGPDDDVCPDEPENNIIAFSPKYENSLSDFRISAIGFRE SQ KYLADDKKKRNGIPIRKMTEAQKGVALDYDTLMARHGGRPDVIMNPAGTVFVGGFVFDRK SQ PTCQDNMQTVYVLRNGYAHRYRIYHCEDTNGIYKFVWPQEQSFDPDSLAKSARVRMVKQV SQ KSPEHMIHHIEEIDESIGHNYRLNRKRRNSETREHELIELDTDDLNEPSTSDGRYSFGHH SQ GYR XX SC SwissProt #P24349 XX SF 7 zinc finger motifs SF acidic region XX FF involved in the control of sexual fate XX DR EMBL: X58520; CESDC1(g). DR SwissProt: P24349; SDC1_CAEEL. DR PIR: A33165; A33165. DR PIR: S15093; S15093. XX RN [1] RA Nonet M. L., Meyer B. J. RT Early aspects of Caenorhabditis elegans sex determination RT and dosage competition are regulated by a zinc-finger protein RL Nature 351:65-68 (1991). XX // AC T00743 XX ID T00743 XX DT 27.01.93 (created); hse. XX FA SEF-1 XX SY S-CBF; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 30-35 kDa (SDS) XX FF activates SL3-3 virus promoter XX MX M00214; V$SEF1_C XX BS R02243; SEF1$CONS; Quality: 6 XX DR Compel: C00104 XX RN [1] RA Thornell A., Hallberg B., Grundstroem T. RT Differential protein binding in lymphocytes to a sequence RT in the enhancer of the mouse retrovirus SL3-3 RL Mol. Cell. Biol. 8:1625-1637 (1988). RN [2] RA Boral A. L., Okenquist S. A., Lenz J. RT Identification of the SL3-3 virus enhancer core as RT a T-lymphoma cell-specific element RL J. Virol. 63:76-84 (1989). XX // AC T00744 XX ID T00744 XX DT 14.12.92 (created); ewi. DT 03.09.96 (updated); ewi. XX FA SGF-1 XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; OC lepidoptera; bombycoidea; bombycidae XX CL C0023; fork head; 3.3.2.0.5. XX SZ 349 AA; 38.8 kDa (cDNA), 40 kDa (SDS) XX SQ MISQKLSYGDVPTSASLSSLSPGLAPPYVNGMGCMPAQPYPNLYSNNMVAGGSCMGSPSV SQ GYSPPSTMASCMGGAGAVPYGSLPREQEAASPTSALQRARNDKTYRRSYTHAKPPYSYIS SQ LITMAIQNNPSRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKVPRTPDK SQ PGKGSFWTLHPDSGNMFENGCFLRRQKRFKDEKKETLRQAQKAQQTHGHHGGSHDKRGEH SQ GHDKSAPPGPGEDKEMRDELLAQLHAAPELCLPEHTPLALEHYAQLKQEPSGYAPAQHPF SQ SITRLLPGADTKADLKMYDVNYGYGHSPADNYYQSPLYHHHHAHAQPPL XX SC translated from EMBL #D38514 XX FT 103 212 fork head domain, homology region FT B, DNA-binding domain (by homology) FT 296 300 hexapeptide HPFSIT, region C XX SF a related protein of 41 kDa has been identified as well [1]; XX CP silk gland; very low: ovary [1]; XX FF most likely activates silk gland-specific genes such as sericin-1 [1]; XX BS R02718; BOMMO$F_07; Quality: 6; silk moth, Bombyx mori BS R02719; BOMMO$F_08; Quality: 6; silk moth, Bombyx mori XX DR EMBL: D38514; BMSGH1(r). XX RN [1] RA Mach V., Takiya S., Ohno K., Handa H., Imai T., Suzuki Y. RT Silk gland factor-1 involved in the regulation of RT Bombyx Sericin-1 gene contains fork head motif RL J. Biol. Chem. 270:9340-9346 (1995). RN [2] RA Hui C.-C., Matsuno K., Suzuki Y. RT Fibroin Gene Promoter Contains a Cluster of Homeodomain RT Binding Sites that Interact with Three Silk Gland Factors RL J. Mol. Biol. 213:651-670 (1990). XX // AC T00745 XX ID T00745 XX DT 14.12.92 (created); ewi. XX FA SGF-2 XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; OC lepidoptera; bombycoidea; bombycidae XX CP posterior silk gland XX BS R00449; BOMMO$F_02; Quality: 6; silk moth, Bombyx mori BS R00450; BOMMO$F_03; Quality: 6; silk moth, Bombyx mori BS R00451; BOMMO$F_04; Quality: 6; silk moth, Bombyx mori XX RN [1] RA Hui C.-C., Matsuno K., Suzuki Y. RT Fibroin Gene Promoter Contains a Cluster of Homeodomain RT Binding Sites that Interact with Three Silk Gland Factors RL J. Mol. Biol. 213:651-670 (1990). XX // AC T00746 XX ID T00746 XX DT 14.12.92 (created); ewi. DT 12.08.96 (updated); ewi. XX FA SGF-3 XX SY Oct-X; POU-M1; XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; OC lepidoptera; bombycoidea; bombycidae XX HO Cf1a (Drosophila) XX CL ; ; 3.1.2.3.1. XX SZ 351 AA; 38.6 kDa (cDNA), 38 kDa (SDS) XX SQ MAATTYMPAEMELGNIGGYHAASPRSAEPADMKYQHPLHSGGSPSPGAPVIGNPWTSLPP SQ ADPWAMHQHHAHAHQPDVKPPPAPHDHRHLQHAAHGWHAPVVSPHYGAARPSHCMEDTQC SQ PCTNTICSETSSPRDPLHHHAMERDQPEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGL SQ ALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGR SQ KRKKRTSIEVSVKGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMT SQ PPNTLGGEMMEGMGHAHYGHGDVHGSPLQHSPPGLSPQHGLPQGAHTLAAH XX SC translated from EMBL #M64781 XX FT 44 63 proline-rich region (7/29) FT 67 74 histidine-rich region (5/8) FT 76 84 proline-rich region (5/9) FT 85 98 histidine-rich region (6/14) FT 150 223 POU-specific domain FT 241 300 POU homeo domain XX SF POU domain identical to that of Drosophila Cf1a, the SF similarity extends towards the C-terminus SF may therefore be the Bombyx homolog of Cf1a [1]; XX CP middle silk gland, lower level in posterior silk gland [1]; XX FF regulator of silk protein genes [3], [2], [4], [1]; FF expression is differentially regulated in middle and FF posterior silk gland [1]; XX BS R00449; BOMMO$F_02; Quality: 6; silk moth, Bombyx mori BS R00450; BOMMO$F_03; Quality: 6; silk moth, Bombyx mori BS R00451; BOMMO$F_04; Quality: 6; silk moth, Bombyx mori BS R02779; CHICK$SMHC_01; Quality: 6; chick, Gallus gallus XX DR EMBL: L01266; BMPOU(r). DR EMBL: M64781; BMPOUM1(r). XX RN [1] RA Fukuta M., Matsuno K., Hui C.-C., Nagata T., Takiya RA S., Xu P.-X., Ueno K., Suzuki Y. RT Molecular cloning of a POU domain-containing factor RT involved in the regulation of the Bombyx sericin-1 gene RL J. Biol. Chem. 268:19471-19475 (1993). RN [2] RA Matsuno K., Suzuki T., Takiya S., Suzuki Y. RT Complex Formation with the Fibroin Gene Enhancer through RT a Protein-Protein Interaction Analyzed by a Modified DNA-binding Assay RL J. Biol. Chem. 264:4599-4604 (1989). RN [3] RA Matsuno K., Hui C.-C., Takiya S., Suzuki T., Ueno K., Suzuki Y. RT Transcription Signals and Protein Binding Sites for RT Sericine Gene Transcription in Vitro RL J. Biol. Chem. 264:18707-18713 (1989). RN [4] RA Hui C.-C., Matsuno K., Suzuki Y. RT Fibroin Gene Promoter Contains a Cluster of Homeodomain RT Binding Sites that Interact with Three Silk Gland Factors RL J. Mol. Biol. 213:651-670 (1990). XX // AC T00747 XX ID T00747 XX DT 14.12.92 (created); ewi. XX FA SGF-4 XX OS silk moth, Bombyx mori OC eukaryota; animalia; metazoa; arthropoda; insecta; OC lepidoptera; bombycoidea; bombycidae XX CP ubiquitous XX BS R00449; BOMMO$F_02; Quality: 6; silk moth, Bombyx mori BS R00450; BOMMO$F_03; Quality: 6; silk moth, Bombyx mori BS R00451; BOMMO$F_04; Quality: 6; silk moth, Bombyx mori XX RN [1] RA Hui C.-C., Matsuno K., Suzuki Y. RT Fibroin Gene Promoter Contains a Cluster of Homeodomain RT Binding Sites that Interact with Three Silk Gland Factors RL J. Mol. Biol. 213:651-670 (1990). XX // AC T00748 XX ID T00748 XX DT 27.01.93 (created); hse. XX FA SIF XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX FF activates c-fos gene expresison in the same time course as SRF XX BS R00458; HS$CFOS_01; Quality: 6; human, Homo sapiens BS R02244; SIF$CONS; Quality: 6 XX RN [1] RA Wagner B. J., Hayes T. E., Hoban C. J., Cochran B. H. RT The SIF binding element confers sis/PDGF inducibility RT onto the c-fos promoter RL EMBO J. 9:4477-4484 (1990). XX // AC T00749 XX ID T00749 XX DT 27.01.93 (created); hse. XX FA SIF XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX FF activates c-fos gene expresison in the same time course as SRF XX BS R02244; SIF$CONS; Quality: 6 XX RN [1] RA Wagner B. J., Hayes T. E., Hoban C. J., Cochran B. H. RT The SIF binding element confers sis/PDGF inducibility RT onto the c-fos promoter RL EMBO J. 9:4477-4484 (1990). XX // AC T00750 XX ID T00750 XX DT 20.10.92 (created); ewi. DT 08.05.96 (updated); ewi. XX FA Sim XX SY Single-minded; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0010; bHLH; 1.2.6.0.3. XX SZ 673 AA; 73.6 kDa (cDNA) XX SQ MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGL SQ GEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG SQ NSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEI SQ EKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHS SQ LPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMA SQ MRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSERE SQ VKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQ SQ AQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPP SQ TNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTAS SQ SAGGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANS SQ NSCSSSSESERQLSTGNASIVNETSPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQHL SQ MEQQHLQYQYATW XX SC SwissProt #P05709 XX FT 2 12 basic region FT 13 53 helix-loop-helix domain FT 83 350 PAS domain FT 97 147 PAS domain repeat 1 FT 263 313 PAS domain repeat 2 FT 382 422 alanine-rich region containing AAQ repeats FT 649 669 glutamine-rich region (12/21) XX SF PAS domain of homology between per, arnt, and sim [2]; SF mediates dimerization of Sim with Per (periodic) which SF regulates the circadian rhythm [1]; SF in a heterodimeric complex with (human) Arnt, Sim SF recognizes the 5'-half-site sequence GTRC [3]; XX FF master regulator of CNS midline development [4]; XX IN T01346; Arnt; human, Homo sapiens. IN T01797; Arnt; mouse, Mus musculus. XX DR EMBL: M19020; DMSIMNP(r). DR SwissProt: P05709; SIM_DROME. DR PIR: A29945; A29945. DR Flybase: FBgn0004666; sim. XX RN [1] RA Huang Z. J., Edery I., Rosbash M. RT PAS is a dimerization domain common to Drosophila RT Period and several transcription factors RL Nature 364:259-262 (1993). RN [2] RA Crews S. T., Thomas J. B., Goodman C. S. RT The Drosophila single-minded gene encodes a nuclear RT protein with sequence similarity to the per gene product RL Cell 52:143-151 (1988). RN [3] RA Swanson H. I., Chan W. K., Bradfield C. A. RT DNA binding specificities and pairing rules of the RT Ah receptor, ARNT, and SIM proteins RL J. Biol. Chem. 270:26292-26302 (1995). RN [4] RA Nambu J. R., Lewis J. O., Wharton Jr. K. A., Crews St. T. RT The Drosophila single-minded gene encodes a helix-loop-helix RT protein that acts as a master regulator of CNS midline development RL Cell 67:1157-1167 (1991). XX // AC T00751 XX ID T00751 XX DT 02.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Sn XX SY Snail; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.2.6. XX SZ 390 AA XX SQ MAANYKSCPLKKRPIVFVEERLPQTEALALTKDSQFAQDQPQDLSLKRGRDEETQDYQQP SQ EPKRDYVLNLSKTPERNSSSSSNSCLLSPPVETQDYLPTEIHMRGLTAGTTGYTTATPTT SQ INPFQSAFVMAAGCNPISALWSSYQPHLAAFPSPASSMASPQSVYSYQQMTPPSSPGSDL SQ ETGSEPEDLSVRNDIPLPALFHLFDEAKSSSSGASVSSSSGYSYTPAMSASSASVAANHA SQ KNYRFKCDECQKMYSTSMGLSKHRQFHCPAAECNQEKKTHSCEECGKLYTTIGALKMHIR SQ THTLPCKCPICGKAFSRPWLLQGHIRTHTGEKPFQCPDCPRSFADRSNLRAHQQTHVDVK SQ KYACQVCHKSFSRMSLLNKHSSSNCTITIA XX SC SwissProt #P08044 XX SF 5 zinc finger motifs XX FF gap gene; FF repressor of Ubx XX MX M00044; I$SN_02 XX BS R04144; AS$SNAIL_01; Quality: 2 BS R04101; DROME$SIM_01; Quality: 2; fruit fly, Drosophila melanogaster BS R04102; DROME$SIM_02; Quality: 2; fruit fly, Drosophila melanogaster BS R04103; DROME$SIM_03; Quality: 2; fruit fly, Drosophila melanogaster BS R04104; DROME$SIM_04; Quality: 2; fruit fly, Drosophila melanogaster BS R04105; DROME$SIM_05; Quality: 2; fruit fly, Drosophila melanogaster BS R04106; DROME$SIM_06; Quality: 2; fruit fly, Drosophila melanogaster BS R04107; SNAIL$CONS_01; Quality: 2 XX DR EMBL: Y00288; DMSNAIL(r). DR SwissProt: P08044; SNAI_DROME. DR PIR: S06222; S06222. DR Flybase: FBgn0003448; sna. XX RN [1] RA Boulay J. L., Dennefeld C., Alberga A. RT The Drosophila developmental gene snail encodes a RT protein with nucleic acid binding fingers RL Nature 330:395-398 (1987). XX // AC T00752 XX ID T00752 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA Sp1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; 2.3.1.0.2. XX SZ 95/105 kDa (SDS) XX SF 3 zinc finger motifs XX FF particularly low levels in some adult organs such FF as liver, apparently absent in adult kidney XX IN T00205; E2; BPV-1, bovine papilloma virus type 1. IN T00752; Sp1; mouse, Mus musculus. XX BS R03445; HS$ALDA_01; Quality: 5; human, Homo sapiens BS R02873; MOUSE$A11COL_04; Quality: 5; mouse, Mus musculus BS R03336; MOUSE$A11COL_07; Quality: 1; mouse, Mus musculus BS R00052; MOUSE$APRT_01; Quality: 5; mouse, Mus musculus BS R00281; MOUSE$DHFR_01; Quality: 4; mouse, Mus musculus BS R00282; MOUSE$DHFR_02; Quality: 5; mouse, Mus musculus BS R02891; MOUSE$EPOR_02; Quality: 5; mouse, Mus musculus BS R03348; MOUSE$EPOR_04; Quality: 5; mouse, Mus musculus BS R01701; MOUSE$GLUT4_02; Quality: 5; mouse, Mus musculus BS R01702; MOUSE$GLUT4_03; Quality: 5; mouse, Mus musculus BS R01704; MOUSE$GLUT4_05; Quality: 5; mouse, Mus musculus BS R02085; MOUSE$HOX23_03; Quality: 5; mouse, Mus musculus BS R03361; MOUSE$HTF9_02; Quality: 4; mouse, Mus musculus BS R01694; MOUSE$IAP_02; Quality: 1; mouse, Mus musculus BS R01164; MOUSE$MBP_03; Quality: 4; mouse, Mus musculus BS R01021; MOUSE$MT1_01; Quality: 5; mouse, Mus musculus BS R01022; MOUSE$MT1_02; Quality: 4; mouse, Mus musculus BS R04160; MOUSE$MYOD_01; Quality: 5; mouse, Mus musculus BS R01680; MOUSE$NCAM_07; Quality: 5; mouse, Mus musculus BS R03205; MOUSE$PBGD_05; Quality: 5; mouse, Mus musculus BS R02593; MOUSE$RPS16_01; Quality: 5; mouse, Mus musculus BS R02846; MOUSE$TK_01; Quality: 4; mouse, Mus musculus BS R02381; MOUSE$TPA_01; Quality: 2; mouse, Mus musculus BS R01769; MOUSE$TS_02; Quality: 2; mouse, Mus musculus BS R03281; MOUSE$TS_05; Quality: 4; mouse, Mus musculus BS R04025; MVM$P4_01; Quality: 2; MVM(p), minute virus of mice BS R01608; RAT$CYTOP_10; Quality: 5; rat, Rattus norvegicus BS R02245; SP1$CONS; Quality: 6 XX DR EMBL: X60136; MMSP1(g). DR Compel: C00132 XX RN [1] RA Somma M. P., Gambino I., Lavia P. RT Transcription factors binding to the mouse HTF9 housekeeping RT promoter differ between cell types RL Nucleic Acids Res. 19:4451-4458 (1991). RN [2] RA Seguin C., Hamer D. H. RT Regulation in Vitro of Metallothionein Gene Binding Factors RL Science 235:1383-1387 (1987). RN [3] RA Hirsch M.-R., Gaugler L., Deagostini-Bazin H., Bally-Cuif L., Goridis C. RT Identification of Positive and Negative Regulatory RT Elements Governing Cell-Type-Specific Expression of RT the Neural Cell Adhesion Molecule Gene RL Mol. Cell. Biol. 10:1959-1968 (1990). RN [4] RA Schmidt M. C., Zhou Q., Berk A. J. RT Sp1 Activates Transcription without Enhancing DNA-Binding RT Activity of the TATA Box Factor RL Mol. Cell. Biol. 9:3299-3307 (1989). RN [5] RA Lemaigre F. P., Lafontaine D. A., Courtois S. J., RA Durviaux S. M., Rousseau G. G. RT Sp1 can displace GHF-1 from its distal binding site RT and stimulate transcription from the growth hormone gene promoter RL Mol. Cell. Biol. 10:1811-1814 (1990). RN [6] RA Pecorino L. T., Darrow A. L., Strickland S. RT In vitro analysis of the tissue plasminogen activator RT promoter reveals a GC box-binding activity present RT in murine brain but undetectable in kidney and liver RL Mol. Cell. Biol. 11:3139-3147 (1991). RN [7] RA Jackson S. P., MacDonald J. J., Lees-Miller S., Tjian R. RT GC box binding induces phosphorylation by a DNA-dependent protein kinase RL Cell 63:155-165 (1990). RN [8] RA Sartorelli V., Webster K. A., Kedes L. RT Muscle-specific expression of the cardiac alpha-actin RT gene requires MyoD1, CArG-box binding factor, and Sp1 RL Genes Dev. 4:1811-1822 (1990). RN [9] RA Saffer J. D., Jackson S. P., Thurston S. J. RT SV40 stimulates expression of the trans-acting factor Sp1 at the mRNA level RL Genes Dev. 4:659-666 (1990). RN [10] RA Su W., Jackson S., Tjian R., Echols H. RT DNA looping between site for transcriptional activation: RT self-association of DNA-bound Sp1 RL Genes Dev. 5:820-826 (1991). RN [11] RA Saffer J. D., Jackson S. P., Annarella M. B. RT Developmental expression of Sp1 in the mouse RL Mol. Cell. Biol. 11:2189-2199 (1991). XX // AC T00753 XX ID T00753 XX DT 15.10.92 (created); ewi. XX FA Sp1 XX OS domestic pig, Sus scrofa OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; artiodactyla; suiformes; suidae XX IN T00205; E2; BPV-1, bovine papilloma virus type 1. XX BS R01540; PIG$UPA_09; Quality: 5; domestic pig, Sus scrofa BS R01541; PIG$UPA_10; Quality: 5; domestic pig, Sus scrofa BS R01542; PIG$UPA_11; Quality: 5; domestic pig, Sus scrofa BS R01545; PIG$UPA_14; Quality: 5; domestic pig, Sus scrofa BS R02245; SP1$CONS; Quality: 6 XX RN [1] RA von der Ahe D., Pearson D., Nakagawa J.-i., Rajput B., Nagamine Y. RT Multiple nuclear factors interact with promoter sequences RT of the urokinase-type plasminogen activator gene RL Nucleic Acids Res. 16:7527 (1988). XX // AC T00754 XX ID T00754 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Sp1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; 2.3.1.0.2. XX SZ 95/105 kDA (SDS) XX SQ MSDQDHSMDEVTAVKIEKGVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQPS SQ PLALLAATCSRIESPNENENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGAT SQ PTSKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIP SQ QFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVP SQ LQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESGSQ SQ PVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTSQ SQ RVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQA SQ APLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNP SQ QAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSAL SQ GTSGIQVHQLPGLPLAIANTPGDHGAQLGLHGPGGDGIHDETAGGEEGENSPDPQPQAGR SQ RTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFM SQ CNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGV SQ ALSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQS SQ INISGNGF XX SC SwissProt #Q01714 XX SF 3 zinc finger motifs XX IN T00205; E2; BPV-1, bovine papilloma virus type 1. XX BS R01696; HS$ADH2_01; Quality: 6; human, Homo sapiens BS R03189; HS$CS1_01; Quality: 3; human, Homo sapiens BS R03957; HS$CSB_03; Quality: 5; human, Homo sapiens BS R04034; HS$FN_07; Quality: 5; human, Homo sapiens BS R00610; HS$GRH_04; Quality: 3; human, Homo sapiens BS R01164; MOUSE$MBP_03; Quality: 4; mouse, Mus musculus BS R00576; RAT$A2UG_04; Quality: 5; rat, Rattus norvegicus BS R04407; RAT$APP_01; Quality: 3; rat, Rattus norvegicus BS R03308; RAT$ARGL_02; Quality: 4; rat, Rattus norvegicus BS R00446; RAT$GF_06; Quality: 1; rat, Rattus norvegicus BS R00447; RAT$GF_07; Quality: 1; rat, Rattus norvegicus BS R02050; RAT$GRH_19; Quality: 4; rat, Rattus norvegicus BS R02051; RAT$GRH_20; Quality: 4; rat, Rattus norvegicus BS R02572; RAT$ME_02; Quality: 5; rat, Rattus norvegicus BS R01023; RAT$MT1_01; Quality: 5; rat, Rattus norvegicus BS R01025; RAT$MT1_03; Quality: 5; rat, Rattus norvegicus BS R03612; RAT$OMP_04; Quality: 5; rat, Rattus norvegicus BS R03613; RAT$OMP_05; Quality: 5; rat, Rattus norvegicus BS R03614; RAT$OMP_06; Quality: 5; rat, Rattus norvegicus BS R03317; RAT$POMC_13; Quality: 4; rat, Rattus norvegicus BS R02245; SP1$CONS; Quality: 6 XX DR EMBL: D12768; RRD12768(r). DR SwissProt: Q01714; SP1_RAT. DR PIR: JS0747; JS0747. DR Compel: C00070 XX RN [1] RA Schmidt M. C., Zhou Q., Berk A. J. RT Sp1 Activates Transcription without Enhancing DNA-Binding RT Activity of the TATA Box Factor RL Mol. Cell. Biol. 9:3299-3307 (1989). RN [2] RA Morgan J. G., Courtois G., Fourel G., Chodosh L. A., RA Campbell L., Evans E., Crabtree G. R. RT Sp1, a CAAT-Binding Factor, and the Adenovirus Major RT Late Promoter Transcription Factor Interact with Functional RT Regions of the Gamma-Fibrinogen Promoter RL Mol. Cell. Biol. 8:2628-2637 (1988). RN [3] RA Choy H. A., McLaughlin M., Feigelson P. RT Nuclear Factors from Expressing Tissues Interact in RT Vitro with with a Rat alpha-2u Globulin Gene Intron RL J. Biol. Chem. 264:1754-1759 (1989). RN [4] RA Lemaigre F. P., Lafontaine D. A., Courtois S. J., RA Durviaux S. M., Rousseau G. G. RT Sp1 can displace GHF-1 from its distal binding site RT and stimulate transcription from the growth hormone gene promoter RL Mol. Cell. Biol. 10:1811-1814 (1990). RN [5] RA Takiguchi M., Mori M. RT In vitro analysis of the rat liver-type arginase promoter RL J. Biol. Chem. 266:9186-9193 (1991). RN [6] RA Jackson S. P., MacDonald J. J., Lees-Miller S., Tjian R. RT GC box binding induces phosphorylation by a DNA-dependent protein kinase RL Cell 63:155-165 (1990). RN [7] RA Sartorelli V., Webster K. A., Kedes L. RT Muscle-specific expression of the cardiac alpha-actin RT gene requires MyoD1, CArG-box binding factor, and Sp1 RL Genes Dev. 4:1811-1822 (1990). RN [8] RA Saffer J. D., Jackson S. P., Thurston S. J. RT SV40 stimulates expression of the trans-acting factor Sp1 at the mRNA level RL Genes Dev. 4:659-666 (1990). RN [9] RA Su W., Jackson S., Tjian R., Echols H. RT DNA looping between site for transcriptional activation: RT self-association of DNA-bound Sp1 RL Genes Dev. 5:820-826 (1991). RN [10] RA Saffer J. D., Jackson S. P., Annarella M. B. RT Developmental expression of Sp1 in the mouse RL Mol. Cell. Biol. 11:2189-2199 (1991). RN [11] RA Schaufele F., West B. L., Reudelhuber T. RT Somatotroph- and lactotroph-specific interactions RT with the homeobox protein binding sites in the rat RT growth hormone gene promoter RL Nucleic Acids Res. 18:5235-5244 (1990). XX // AC T00755 XX ID T00755 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA Sp1 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0001; CH; . XX SZ 95/105 kDa (SDS) XX SF 3 zinc finger motifs XX IN T00205; E2; BPV-1, bovine papilloma virus type 1. IN T00755; Sp1; chick, Gallus gallus. XX BS R00015; CHICK$ACRA_05; Quality: 5; chick, Gallus gallus BS R00017; CHICK$ACRA_07; Quality: 1; chick, Gallus gallus BS R00528; CHICK$BAG_02; Quality: 2; chick, Gallus gallus BS R00252; CHICK$D1CR_01; Quality: 1; chick, Gallus gallus BS R02590; CHICK$LYS_26; Quality: 4; chick, Gallus gallus BS R03123; CHICK$VIT2_20; Quality: 1; chick, Gallus gallus BS R04160; MOUSE$MYOD_01; Quality: 5; mouse, Mus musculus BS R02245; SP1$CONS; Quality: 6 XX DR Compel: C00005 DR Compel: C00006 DR Compel: C00010 DR Compel: C00027 XX RN [1] RA Schmidt M. C., Zhou Q., Berk A. J. RT Sp1 Activates Transcription without Enhancing DNA-Binding RT Activity of the TATA Box Factor RL Mol. Cell. Biol. 9:3299-3307 (1989). RN [2] RA Lemaigre F. P., Lafontaine D. A., Courtois S. J., RA Durviaux S. M., Rousseau G. G. RT Sp1 can displace GHF-1 from its distal binding site RT and stimulate transcription from the growth hormone gene promoter RL Mol. Cell. Biol. 10:1811-1814 (1990). RN [3] RA Seal S. N., Davis D. L., Burch J. B. E. RT Mutational studies reveal a complex set of positive RT and negative control elements within the chicken vitellogenin II promoter RL Mol. Cell. Biol. 11:2704-2717 (1991). RN [4] RA Piette J., Klarsfeld A., Changeux J.-P. RT Interaction of nuclear factors with the upstream region RT of the alpha-subunit gene of chicken muscle acetylcholine RT receptor: variations with muscle differentiation and denervation RL EMBO J. 8:687-694 (1989). RN [5] RA Jackson S. P., MacDonald J. J., Lees-Miller S., Tjian R. RT GC box binding induces phosphorylation by a DNA-dependent protein kinase RL Cell 63:155-165 (1990). RN [6] RA Sartorelli V., Webster K. A., Kedes L. RT Muscle-specific expression of the cardiac alpha-actin RT gene requires MyoD1, CArG-box binding factor, and Sp1 RL Genes Dev. 4:1811-1822 (1990). RN [7] RA Saffer J. D., Jackson S. P., Thurston S. J. RT SV40 stimulates expression of the trans-acting factor Sp1 at the mRNA level RL Genes Dev. 4:659-666 (1990). RN [8] RA Su W., Jackson S., Tjian R., Echols H. RT DNA looping between site for transcriptional activation: RT self-association of DNA-bound Sp1 RL Genes Dev. 5:820-826 (1991). RN [9] RA Saffer J. D., Jackson S. P., Annarella M. B. RT Developmental expression of Sp1 in the mouse RL Mol. Cell. Biol. 11:2189-2199 (1991). XX // AC T00757 XX ID T00757 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA Sp1 XX OS monkey, Cercopithecus aethiops OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; primates; haplorhini; OC catarrhini; cercopithecidae; cercopithecinae XX CL C0001; CH; . XX SZ 95/105 kDa (SDS) XX SF 3 zinc finger motifs SF Ph. SF O-glycosylation XX IN T00205; E2; BPV-1, bovine papilloma virus type 1. IN T00757; Sp1; monkey, Cercopithecus aethiops. XX BS R02660; RAT$CYCS_03; Quality: 1; rat, Rattus norvegicus BS R02245; SP1$CONS; Quality: 6 BS R01376; SV$SV40_08; Quality: 1; SV40, simian virus 40 BS R01382; SV$SV40_14; Quality: 5; SV40, simian virus 40 XX RN [1] RA Buchanan R. L., Gralla J. D. RT Factor Interaction at Simian Virus 40 GC-Box Promoter RT Elements in Intact Nuclei RL Mol. Cell. Biol. 7:1554-1558 (1987). RN [2] RA Schmidt M. C., Zhou Q., Berk A. J. RT Sp1 Activates Transcription without Enhancing DNA-Binding RT Activity of the TATA Box Factor RL Mol. Cell. Biol. 9:3299-3307 (1989). RN [3] RA Lemaigre F. P., Lafontaine D. A., Courtois S. J., RA Durviaux S. M., Rousseau G. G. RT Sp1 can displace GHF-1 from its distal binding site RT and stimulate transcription from the growth hormone gene promoter RL Mol. Cell. Biol. 10:1811-1814 (1990). RN [4] RA Jackson S. P., MacDonald J. J., Lees-Miller S., Tjian R. RT GC box binding induces phosphorylation by a DNA-dependent protein kinase RL Cell 63:155-165 (1990). RN [5] RA Sartorelli V., Webster K. A., Kedes L. RT Muscle-specific expression of the cardiac alpha-actin RT gene requires MyoD1, CArG-box binding factor, and Sp1 RL Genes Dev. 4:1811-1822 (1990). RN [6] RA Saffer J. D., Jackson S. P., Thurston S. J. RT SV40 stimulates expression of the trans-acting factor Sp1 at the mRNA level RL Genes Dev. 4:659-666 (1990). RN [7] RA Su W., Jackson S., Tjian R., Echols H. RT DNA looping between site for transcriptional activation: RT self-association of DNA-bound Sp1 RL Genes Dev. 5:820-826 (1991). RN [8] RA Saffer J. D., Jackson S. P., Annarella M. B. RT Developmental expression of Sp1 in the mouse RL Mol. Cell. Biol. 11:2189-2199 (1991). XX // AC T00758 XX ID T00758 XX DT 15.10.92 (created); ewi. XX FA Sp1 XX OS clawed frog, Xenopus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX IN T00205; E2; BPV-1, bovine papilloma virus type 1. XX BS R02245; SP1$CONS; Quality: 6 BS R01502; XENLA$U2SN_08; Quality: 5; clawed frog, Xenopus laevis BS R01503; XENLA$U2SN_09; Quality: 5; clawed frog, Xenopus laevis XX RN [1] RA Tebb G., Mattaj I. W. RT The Xenopus laevis U2 Gene Distal Sequence Element RT (Enhancer) Is Composed of Four Subdomains That Can RT Act Independently and Are Partly Functionally Redundant RL Mol. Cell. Biol. 9:1682-1690 (1989). XX // AC T00759 XX ID T00759 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Sp1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0001; CH; 2.3.1.0.2. XX SZ >696 AA; 105+95 kDa (SDS) XX SQ TGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGSSTNGSNGSESSKNRTVSGGQYVV SQ AAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPG SQ ANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPV SQ NSVSAATLTPSSQAVTISSSGSQESGSQPVTSGTTISSASLVSSQASSSSFFTNANSYST SQ TTTTSNMGIMNFTTSGSSGTNSQGQTPQRVSGLQGSDALNIQQNQTSGGSLQAGQQKEGE SQ QNQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVPNSGPI SQ IIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAA SQ SIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHPIQGLPLAIANAPGDHGAQLGLHG SQ AGGDGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICH SQ IQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQRHKRTHTGEKKFACP SQ ECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGSGTATPSALITTNMV SQ AMEAICPEGIARLANSGINVMQVADLQSINISGNGF XX SC SwissProt #P08047 XX SF 3 zinc finger motifs SF Q SF Zn2+ can be substituted for Cd2+, Co2+, less favourable: Mn2+, Ni2+ SF thionein inhibits DNA-binding SF Kd 0.41-0.53 nM SF t1/2 for binding to and dissoc. from DNA < 1 min SF phosphorylation (DNA-dependent protein kinase) XX CP (HeLa) XX FF multimerization leads to superactivation; FF effect of Sp1-sites depends on distance to TATA-box [55]; FF synergistically cooperates with E2 at BPV promoters XX IN T00205; E2; BPV-1, bovine papilloma virus type 1. IN T00759; Sp1; human, Homo sapiens. IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX MX M00008; V$SP1_01 XX BS R01991; AD$E1A_15; Quality: 4; adenovirus type 5 BS R01765; AD$E1B_01; Quality: 2; adenovirus BS R01764; AD$E1B_02; Quality: 2; adenovirus BS R00315; AD$E1B_03; Quality: 2; adenovirus type 2 BS R00337; AD$E2L_05; Quality: 4; adenovirus type 2 BS R00338; AD$E2L_06; Quality: 4; adenovirus type 2 BS R00004; AD$IVA2_01; Quality: 4; adenovirus BS R03720; AS$E2SP1_01; Quality: 6 BS R02101; AS$SP1_01; Quality: 2 BS R02102; AS$SP1_02; Quality: 6 BS R02103; AS$SP1_03; Quality: 2 BS R02104; AS$SP1_04; Quality: 2 BS R02105; AS$SP1_05; Quality: 2 BS R02106; AS$SP1_06; Quality: 2 BS R02107; AS$SP1_07; Quality: 2 BS R02108; AS$SP1_08; Quality: 2 BS R02109; AS$SP1_09; Quality: 2 BS R02110; AS$SP1_10; Quality: 2 BS R02111; AS$SP1_11; Quality: 2 BS R02112; AS$SP1_12; Quality: 2 BS R02113; AS$SP1_13; Quality: 2 BS R00191; BPV1$BPV1_21; Quality: 2; BPV-1, bovine papilloma virus type 1 BS R03282; BPV1$BPV1_24; Quality: 2; BPV-1, bovine papilloma virus type 1 BS R02010; CHICK$BAG_10; Quality: 2; chick, Gallus gallus BS R02013; CHICK$BAG_13; Quality: 2; chick, Gallus gallus BS R01802; HA$DHR_02; Quality: 5; hamster, Cricetulus griseus BS R01908; HA$DHR_04; Quality: 5; hamster, Cricetulus griseus BS R01909; HA$DHR_05; Quality: 5; hamster, Cricetulus griseus BS R00704; HIV1$HIV1_11; Quality: 1; HIV-1, human immunodeficiency virus type 1 BS R02922; HPV$HPV16_12; Quality: 3; HPV-16, human papilloma virus type 16 BS R00224; HS$A11COL_01; Quality: 5; human, Homo sapiens BS R01754; HS$AAC_10; Quality: 2; human, Homo sapiens BS R01756; HS$AAC_11; Quality: 2; human, Homo sapiens BS R01758; HS$AAC_13; Quality: 2; human, Homo sapiens BS R01753; HS$AAC_14; Quality: 2; human, Homo sapiens BS R01755; HS$AAC_15; Quality: 2; human, Homo sapiens BS R01761; HS$AAC_16; Quality: 2; human, Homo sapiens BS R01762; HS$AAC_17; Quality: 2; human, Homo sapiens BS R01763; HS$AAC_18; Quality: 2; human, Homo sapiens BS R03445; HS$ALDA_01; Quality: 5; human, Homo sapiens BS R03448; HS$ALDA_04; Quality: 5; human, Homo sapiens BS R04426; HS$APE_02; Quality: 2; human, Homo sapiens BS R03666; HS$APOB_15; Quality: 5; human, Homo sapiens BS R00149; HS$APOE_08; Quality: 5; human, Homo sapiens BS R00150; HS$APOE_09; Quality: 6; human, Homo sapiens BS R03051; HS$ASCC_01; Quality: 1; human, Homo sapiens BS R03052; HS$ASCC_02; Quality: 1; human, Homo sapiens BS R03053; HS$ASCC_03; Quality: 1; human, Homo sapiens BS R04421; HS$CEA_02; Quality: 2; human, Homo sapiens BS R04422; HS$CEA_03; Quality: 2; human, Homo sapiens BS R00955; HS$CJUN_01; Quality: 5; human, Homo sapiens BS R02423; HS$CREBP1_01; Quality: 2; human, Homo sapiens BS R02424; HS$CREBP1_02; Quality: 2; human, Homo sapiens BS R02426; HS$CREBP1_04; Quality: 2; human, Homo sapiens BS R02428; HS$CREBP1_06; Quality: 2; human, Homo sapiens BS R02432; HS$CREBP1_10; Quality: 2; human, Homo sapiens BS R02433; HS$CREBP1_11; Quality: 2; human, Homo sapiens BS R02435; HS$CREBP1_13; Quality: 2; human, Homo sapiens BS R02436; HS$CREBP1_14; Quality: 2; human, Homo sapiens BS R02438; HS$CREBP1_16; Quality: 2; human, Homo sapiens BS R02439; HS$CREBP1_17; Quality: 2; human, Homo sapiens BS R02440; HS$CREBP1_18; Quality: 2; human, Homo sapiens BS R03189; HS$CS1_01; Quality: 3; human, Homo sapiens BS R02717; HS$CYP_02; Quality: 6; human, Homo sapiens BS R00287; HS$DPOLB_01; Quality: 5; human, Homo sapiens BS R00374; HS$EGFR_01; Quality: 6; human, Homo sapiens BS R00377; HS$EGFR_04; Quality: 6; human, Homo sapiens BS R00378; HS$EGFR_05; Quality: 6; human, Homo sapiens BS R00381; HS$EGFR_08; Quality: 6; human, Homo sapiens BS R00385; HS$EGFR_12; Quality: 1; human, Homo sapiens BS R03118; HS$EG_06; Quality: 1; human, Homo sapiens BS R04124; HS$GFAP_03; Quality: 5; human, Homo sapiens BS R02599; HS$GG_23; Quality: 4; human, Homo sapiens BS R02621; HS$GG_24; Quality: 6; human, Homo sapiens BS R04195; HS$GG_36; Quality: 4; human, Homo sapiens BS R02444; HS$GPC_04; Quality: 5; human, Homo sapiens BS R02446; HS$GPC_06; Quality: 5; human, Homo sapiens BS R00610; HS$GRH_04; Quality: 6; human, Homo sapiens BS R00769; HS$HSP70_10; Quality: 1; human, Homo sapiens BS R01770; HS$HSP70_12; Quality: 1; human, Homo sapiens BS R03287; HS$INSR_03; Quality: 6; human, Homo sapiens BS R01039; HS$MT2A_10; Quality: 4; human, Homo sapiens BS R02026; HS$NPY_01; Quality: 6; human, Homo sapiens BS R02027; HS$NPY_02; Quality: 6; human, Homo sapiens BS R02029; HS$NPY_04; Quality: 6; human, Homo sapiens BS R03354; HS$PAI_06; Quality: 5; human, Homo sapiens BS R03868; HS$PCNA_01; Quality: 4; human, Homo sapiens BS R01305; HS$RAS1_01; Quality: 5; human, Homo sapiens BS R01306; HS$RAS1_02; Quality: 5; human, Homo sapiens BS R01307; HS$RAS1_03; Quality: 5; human, Homo sapiens BS R01308; HS$RAS1_04; Quality: 5; human, Homo sapiens BS R01309; HS$RAS1_05; Quality: 5; human, Homo sapiens BS R01310; HS$RAS1_06; Quality: 5; human, Homo sapiens BS R01728; HS$TGFB1_03; Quality: 6; human, Homo sapiens BS R01729; HS$TGFB1_04; Quality: 6; human, Homo sapiens BS R02857; HS$TPI_01; Quality: 2; human, Homo sapiens BS R02858; HS$TPI_02; Quality: 2; human, Homo sapiens BS R02859; HS$TPI_03; Quality: 2; human, Homo sapiens BS R02860; HS$TPI_04; Quality: 2; human, Homo sapiens BS R01497; HS$U2SN_03; Quality: 5; human, Homo sapiens BS R01498; HS$U2SN_04; Quality: 5; human, Homo sapiens BS R01499; HS$U2SN_05; Quality: 5; human, Homo sapiens BS R04375; HS$WAF1_03; Quality: 3; human, Homo sapiens BS R04376; HS$WAF1_04; Quality: 3; human, Homo sapiens BS R00565; HS$ZG_01; Quality: 6; human, Homo sapiens BS R00570; HS$ZG_06; Quality: 6; human, Homo sapiens BS R00816; HSV1$IE3_04; Quality: 5; HSV-1, herpes simplex virus type 1 BS R00817; HSV1$IE3_05; Quality: 5; HSV-1, herpes simplex virus type 1 BS R00818; HSV1$IE3_06; Quality: 5; HSV-1, herpes simplex virus type 1 BS R00819; HSV1$IE3_07; Quality: 5; HSV-1, herpes simplex virus type 1 BS R00821; HSV1$IE3_09; Quality: 5; HSV-1, herpes simplex virus type 1 BS R00823; HSV1$IE4_01; Quality: 5; HSV-1, herpes simplex virus type 1 BS R00825; HSV1$IE4_03; Quality: 5; HSV-1, herpes simplex virus type 1 BS R00826; HSV1$IE4_04; Quality: 5; HSV-1, herpes simplex virus type 1 BS R01442; HSV1$TK_01; Quality: 5; HSV-1, herpes simplex virus type 1 BS R01444; HSV1$TK_03; Quality: 5; HSV-1, herpes simplex virus type 1 BS R01771; HSV1$TK_07; Quality: 1; HSV-1, herpes simplex virus type 1 BS R01772; HSV1$TK_08; Quality: 1; HSV-1, herpes simplex virus type 1 BS R03991; HSV2$VMW65_02; Quality: 4; HSV-2, herpes simplex virus type 2 BS R02704; HT1$HTLV1_16; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R02873; MOUSE$A11COL_04; Quality: 2; mouse, Mus musculus BS R03336; MOUSE$A11COL_07; Quality: 2; mouse, Mus musculus BS R03722; MOUSE$ADA_02; Quality: 2; mouse, Mus musculus BS R04008; MOUSE$ADA_04; Quality: 2; mouse, Mus musculus BS R04009; MOUSE$ADA_05; Quality: 2; mouse, Mus musculus BS R01927; MOUSE$DHFR_07; Quality: 5; mouse, Mus musculus BS R04005; MOUSE$ECADH_02; Quality: 2; mouse, Mus musculus BS R02891; MOUSE$EPOR_02; Quality: 5; mouse, Mus musculus BS R03382; MOUSE$JUND_02; Quality: 5; mouse, Mus musculus BS R03385; MOUSE$JUND_05; Quality: 5; mouse, Mus musculus BS R03389; MOUSE$JUND_09; Quality: 6; mouse, Mus musculus BS R03475; MOUSE$MB1_01; Quality: 3; mouse, Mus musculus BS R01022; MOUSE$MT1_02; Quality: 4; mouse, Mus musculus BS R02850; MOUSE$SPIP12_02; Quality: 2; mouse, Mus musculus BS R03041; MOUSE$THY1_01; Quality: 2; mouse, Mus musculus BS R03042; MOUSE$THY1_02; Quality: 3; mouse, Mus musculus BS R03044; MOUSE$THY1_04; Quality: 3; mouse, Mus musculus BS R02381; MOUSE$TPA_01; Quality: 6; mouse, Mus musculus BS R01769; MOUSE$TS_02; Quality: 6; mouse, Mus musculus BS R03281; MOUSE$TS_05; Quality: 6; mouse, Mus musculus BS R03486; PIG$APN_03; Quality: 1; domestic pig, Sus scrofa BS R03422; PRV$IE_07; Quality: 4; pseudorabies virus BS R04282; RAT$ATP1A1_01; Quality: 2; rat, Rattus norvegicus BS R02660; RAT$CYCS_03; Quality: 1; rat, Rattus norvegicus BS R04431; RAT$FAS_02; Quality: 1; rat, Rattus norvegicus BS R02693; RAT$IGF2_01; Quality: 5; rat, Rattus norvegicus BS R01172; RAT$NF1_02; Quality: 6; rat, Rattus norvegicus BS R02448; RAT$TGFA_01; Quality: 6; rat, Rattus norvegicus BS R02245; SP1$CONS; Quality: 6 BS R01375; SV$SV40_07; Quality: 2; SV40, simian virus 40 BS R01376; SV$SV40_08; Quality: 1; SV40, simian virus 40 BS R01377; SV$SV40_09; Quality: 5; SV40, simian virus 40 BS R01378; SV$SV40_10; Quality: 5; SV40, simian virus 40 BS R01379; SV$SV40_11; Quality: 5; SV40, simian virus 40 BS R01380; SV$SV40_12; Quality: 5; SV40, simian virus 40 BS R01381; SV$SV40_13; Quality: 2; SV40, simian virus 40 XX DR EMBL: J03133; HSTFSP1(r). DR SwissProt: P08047; SP1_HUMAN. DR PIR: A29635; A29635. XX RN [1] RA Angel P., Hattori K., Smeal T., Karin M. RT The jun Proto-Oncogene Is Positively Autoregulated by Its Product, Jun/AP-1 RL Cell 55:875-885 (1988). RN [2] RA Westin G., Schaffner W. RT A zinc-responsive factor interacts with a metal-regulated RT enhancer element (MRE) of the mouse metallothionein-I gene RL EMBO J. 7:3763-3770 (1988). RN [3] RA Mitchell P., Wang C., Tjian R. RT Positive and Negative Regulation of Transcription RT In Vitro: Enhancer-Binding Protein AP-2 Is Inhibited by SV40 T Antigen RL Cell 50:847-861 (1987). RN [4] RA Lee W., Haslinger A., Karin M., Tjian R. RT Activation of transcription by two factors that bind RT promoter and enhancer sequences of the human metallothionein gene and SV40 RL Nature 325:368-372 (1987). RN [5] RA Harrington M., Jones P. A., Imagawa M., Karin M. RT Cytosine methylation does not affect binding of transcription factor Sp1 RL Proc. Natl. Acad. Sci. USA 85:2066-2070 (1988). RN [6] RA Emili A., Greenblatt J., Ingles C. J. RT Species-specific interaction of the glutamine-rich RT acitvation domains of Sp1 with the TATA box-binding protein RL Mol. Cell. Biol. 14:1582-1593 (1994). RN [7] RA Ishii S., Kadonaga J. T., Tjian R., Brady J. N., Merlin G. T., Pastan I. RT Binding of the Sp1 Transcription Factor by the Human RT Harvey ras1 Proto-oncogene Promoter RL Science 232:1410-1413 (1986). RN [8] RA Dynan W. S., Safer J. D., Lee W. S., Tjian R. RT Transcription factor Sp1 recognizes promoter sequences RT from the monkey genome that are similiar to the simian virus 40 promoter RL Proc. Natl. Acad. Sci. USA 82:4915-4919 (1985). RN [9] RA Gidoni D., Kadonaga J. T., Barrera-Saldana H., Takahashi RA K., Chambon P., Tjian R. RT Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions RL Science 230:511-517 (1985). RN [10] RA Gidoni D., Dynan W. S., Tjian R. RT Multiple specific contacts between a mammalian transcription RT factor and its cognate promoters RL Nature 312:409-413 (1984). RN [11] RA Westin G., Schaffner W. RT Heavy metal ions in transcription factors from HeLa RT cells: Sp1, but not octamer transcription factor requires RT zinc for DNA binding and for activator functions RL Nucleic Acids Res. 16:5771-5781 (1988). RN [12] RA Courey A. J., Tjian R. RT Analysis of Sp1 in vivo reveals multiple transcriptional RT domains, including a novel glutamine-rich activation motif RL Cell 55:887-898 (1988). RN [13] RA Dynan W. S., Tjian R. RT The Promoter-Specific transcription Factor Sp1 Binds RT to Upstream Sequences in the Sv40 Early Promoter RL Cell 35:79-87 (1983). RN [14] RA Jones K. A., Yamamoto K. R., Tjian R. RT Two distinct transcription factors that bind to the RT HSV thymidine kinase promoter in vitro RL Cell 42:559-572 (1985). RN [15] RA Janson L., Bark C., Petterson U. RT Identification of proteins interacting with the enhancer RT of human U2 small nuclear RNA genes RL Nucleic Acids Res. 15:4997-5016 (1987). RN [16] RA Paik Y.-K., Chang D. J., Reardon C. A., Walker M. RA D., Taxman E., Taylor J. M. RT Identification and Characterization of Transcriptional RT Regulatory Regions Associated with Expression of the RT Human Apolipoprotein E Gene RL J. Biol. Chem. 263:13340-13349 (1988). RN [17] RA Smith J. D., Melian A., Leff T., Breslow J. L. RT Expression of the Human Apolipoprotein E Gene is Regulated RT by Multiple Positive and Negative Elements RL J. Biol. Chem. 263:8300-8308 (1988). RN [18] RA Kadonaga J. T., Carner K. R., Masiarz F. R., Tjian R. RT Isolation of cDNA encoding transcription factor Sp1 RT and functional analysis of the DNA binding domain RL Cell 51:1079-1090 (1987). RN [19] RA Das G. C., Piatigorsky J. RT The chicken delta1-crystallin gene promoter: binding RT of transcription factor(s) to the upstream G+C-rich RT region is necessary for promoter function invitro RL Proc. Natl. Acad. Sci. USA 83:3131-3135 (1986). RN [20] RA Dynan W. S., Sazer S., Tjian R., Schimke R. T. RT Transcription factor Sp1 recognizes a DNA sequence RT in the mouse dihydrofolate reductase promoter RL Nature 319:246-248 (1986). RN [21] RA Kim S.-J., Denhez F., Kim K. Y., Holt J. T., Sporn M. B., Roberts A. B. RT Activation of the Second Promoter of the Transforming RT Growth Factor-beta1 Gene by Transforming Growth Factor-beta1 RT and Phorbol Ester Occurs through the Same Target Sequences RL J. Biol. Chem. 264:19373-19378 (1989). RN [22] RA Gustafson T. A., Kedes L. RT Identification of Multiple Proteins That Interact RT with Functional Regions of the Human Cardiac alpha-Actin Promoter RL Mol. Cell. Biol. 9:3269-3283 (1989). RN [23] RA Schmidt M. C., Zhou Q., Berk A. J. RT Sp1 Activates Transcription without Enhancing DNA-Binding RT Activity of the TATA Box Factor RL Mol. Cell. Biol. 9:3299-3307 (1989). RN [24] RA Morgan W. D. RT Transcriptional Factor Sp1 Binds to and Activates RT a Human hsp70 Gene Promoter RL Mol. Cell. Biol. 9:4099-4104 (1989). RN [25] RA Johnson A. C., Jinno Y., Merlino G. T. RT Modulation of Epidermal Growth Factor Receptor Proto-Oncogene RT Transcription by a promoter Site Sensitive to S1 Nuclease RL Mol. Cell. Biol. 8:4174-4184 (1988). RN [26] RA Hughes M. J., Jost J.-P. RT The ubiquitous nuclear protein, NHP1, binds with high RT affinity to different sequences of the chicken vitellogenin II gene RL Nucleic Acids Res. 17:8511ff (1989). RN [27] RA Sykes K., Kaufman R. RT A Naturally Occurring Gamma Globin Gene Mutation Enhances RT SP1 Binding Activity RL Mol. Cell. Biol. 10:95-102 (1990). RN [28] RA Ben-Hattar J., Beard P., Jiricny J. RT Cytosine methylation in CTF and Sp1 recognition sites RT of an HSV tk promoter: effects on transcription in RT vivo and on factor binding in vitro RL Nucleic Acids Res. 17:10179-10190 (1989). RN [29] RA Ronchi A., Nicolis S., Santoro C., Ottolenghi S. RT Increased Sp1 binding mediates erythroid-specific RT overexpression of a mutated (HPFH) gamma-globulin promoter RL Nucleic Acids Res. 17:10231-10241 (1989). RN [30] RA Evans M. J., Scarpulla R. C. RT Interaction of Nuclear Factors with Multiple Sites RT in the Somatic Cytochrome c Promoter RL J. Biol. Chem. 264:14361-14368 (1989). RN [31] RA Lemaigre F. P., Lafontaine D. A., Courtois S. J., RA Durviaux S. M., Rousseau G. G. RT Sp1 can displace GHF-1 from its distal binding site RT and stimulate transcription from the growth hormone gene promoter RL Mol. Cell. Biol. 10:1811-1814 (1990). RN [32] RA Boyer T. G., Maquat L. E. RT Minimal sequence and factor requirements for the initiation RT of transcription from an atypical, TATATAA box-containing RT housekeeping promoter RL J. Biol. Chem. 265:20524-20532 (1990). RN [33] RA Garcia J. A., Wu F. K., Mitsuyasu R., Gaynor R. B. RT Interaction of cellular proteins involved in the transcriptional RT regulation of the human immunodeficiency virus RL EMBO J. 6:3761-3770 (1987). RN [34] RA Jones K. A., Kadonaga J. T., Luciw P. A., Tjian R. RT Activation of the AIDS retrovirus promoter by the RT cellular transcription factor, Sp1 RL Science 232:755-759 (1986). RN [35] RA Greene J. M., Larin Z., Taylor I. C. A., Prentice RA H., Gwinn K. A., Kingston R. E. RT Multiple Basal Elements of a Human hsp70 Promoter RT Function Differently in Human and Rodent Cell Lines RL Mol. Cell. Biol. 7:3646-3655 (1987). RN [36] RA Spanopoulou E., Giguere V., Grosveld F. RT The functional domains of the murine Thy-1 gene promoter RL Mol. Cell. Biol. 11:2216-2228 (1991). RN [37] RA Anderson G. M., Freytag S. O. RT Synergistic activation of a human promoter in vivo RT by transcription factor Sp1 RL Mol. Cell. Biol. 11:1935-1943 (1991). RN [38] RA Dou Q.-P., Fridovich-Keil J. L., Pardee A. B. RT Inducible proteins binding to the murine thymidine RT kinase promoter in late G1/S phase RL Proc. Natl. Acad. Sci. USA 88:1157-1161 (1991). RN [39] RA Jones K. A., Tjian R. RT Sp1 binds to promoter sequences and activates herpes RT simplex virus 'immediate-early' gene transcription in vitro RL Nature 317:179-182 (1985). RN [40] RA Kagawa N., Waterman M. R. RT Evidence that an adrenal-specific nuclear protein RT regulates the cAMP responsiveness of the human CYP21B (P450C21) gene RL J. Biol. Chem. 266:11199-11204 (1991). RN [41] RA Li R., Knight J. D., Jackson S. P., Tijan R., Botchan M. R. RT Direct interaction between Sp1 and the BPV Enhancer RT E2 protein mediates synergistic activation of transcription RL Cell 65:493-505 (1991). RN [42] RA Araki E., Murakami T., Shirotani T., Kanai F., Shinohara RA Y., Shimada F., Mori M., Shichiri M., Ebina Y. RT A cluster of four Sp1 binding sites required for efficient RT expression of the human insulin receptor gene RL J. Biol. Chem. 266:3944-3948 (1991). RN [43] RA Yu C.-Y., Motamed K., Chen J., Bailey A. D., Shen C.-K. J. RT The CACC box upstream of human embryonic epsilon globin RT gene binds Sp1 and is a functional promoter element in vitro and in vivo RL J. Biol. Chem. 266:8907-8915 (1991). RN [44] RA Miralles V. J., Cortes P., Stone N., Reinberg D. RT The adenovirus inverted terminal repeat functions RT as an enhancer in a cell-free system RL J. Biol. Chem. 264:10763-10772 (1989). RN [45] RA Dush M. K., Briggs M. R., Royce M. E., Schaff D. A., RA Khan S. A., Tischfeld J. A., Stambrook P. J. RT Identification of DNA sequences required for mouse APRT gene expression RL Nucleic Acids Res. 16:8509-8524 (1988). RN [46] RA Letovsky J., Dynan W. S. RT Measurement of the binding of transcription factor RT Sp1 to a single GC box recognition sequence RL Nucleic Acids Res. 17:2639-2653 (1989). RN [47] RA Jackson S. P., MacDonald J. J., Lees-Miller S., Tjian R. RT GC box binding induces phosphorylation by a DNA-dependent protein kinase RL Cell 63:155-165 (1990). RN [48] RA Sartorelli V., Webster K. A., Kedes L. RT Muscle-specific expression of the cardiac alpha-actin RT gene requires MyoD1, CArG-box binding factor, and Sp1 RL Genes Dev. 4:1811-1822 (1990). RN [49] RA Saffer J. D., Jackson S. P., Thurston S. J. RT SV40 stimulates expression of the trans-acting factor Sp1 at the mRNA level RL Genes Dev. 4:659-666 (1990). RN [50] RA Su W., Jackson S., Tjian R., Echols H. RT DNA looping between site for transcriptional activation: RT self-association of DNA-bound Sp1 RL Genes Dev. 5:820-826 (1991). RN [51] RA Saffer J. D., Jackson S. P., Annarella M. B. RT Developmental expression of Sp1 in the mouse RL Mol. Cell. Biol. 11:2189-2199 (1991). RN [52] RA Pascal E., Tjian R. RT Different activation domains of Sp1 govern formation RT of multimers and mediate transcriptional synergism RL Genes Dev. 5:1646-1656 (1991). RN [53] RA Thiesen H.-J., Schroeder B. RT Amino acid substitutions in the Sp1 zinc finger domain RT alter the DNA binding affinity to cognate Sp1 target site RL Biochem. Biophys. Res. Commun. 175:333-338 (1991). RN [54] RA Thiesen H.-J., Bach C. RT Transition metals modulate DNA-protein interactions RT of Sp1 zinc finger domains with its cognate target site RL Biochem. Biophys. Res. Commun. 176:551-557 (1991). RN [55] RA Segal R., Berk A. J. RT Promoter activity and distance constraints of one RT versus two Sp1 binding sites RL J. Biol. Chem. 266:20406-20411 (1991). RN [56] RA Mastrangelo I. A., Courey A. J., Wall J. S., Jackson S. P., Hough P. V. C. RT DNA looping and Sp1 multimer links: a mechanism for RT transcriptional synergism and enhancement RL Proc. Natl. Acad. Sci. USA 88:5670-5674 (1991). RN [57] RA Su W., Jackson S., Tjian R., Echols H. RT DNA looping between site for transcriptional activation: RT self-association of DNA-bound Sp1 RL Genes Dev. 5:820-826 (1991). RN [58] RA Zeng J., Heuchel R., Schaffner W., Kaegi J. H. R. RT Thionein (apometallothionein) can modulate DNA binding RT and transcription activation by zinc finger containing factor Sp1 RL FEBS Lett. 279:310-312 (1992). RN [59] RA Courey A. J., Holtzman D. A., Jackson S. P., Tjian R. RT Synergistic activation by the glutamine-rich domains RT of human transcription factor Sp1 RL Cell 59:827-836 (1989). RN [60] RA Jackson S. P., MacDonald J. J., Lees-Miller S., Tjian R. RT GC box binding induces phosphorylation by a DNA-dependent protein kinase RL Cell 63:155-165 (1990). RN [61] RA Thiesen H.-J., Bach Ch. RT Target detection assay (TDA): a versatile procedure RT to determine DNA binding sites as demonstrated on SP1 protein RL Nucleic Acids Res. 18:3202- (1990). RN [62] RA Nardelli J., Gibson T. J., Vesque C., Charnay P. RT Base sequence discrimination by zinc-finger DNA-binding domains RL Nature 349:175-178 (1991). RN [63] RA Chen X., Azizkhan J. C., Lee D. C. RT The binding of transcription factor SP1 to multiple RT sites is required for maximal expression from the RT rat transforming growth factor alpha promoter RL Oncogene 7:1805-1815 (1992). XX // AC T00760 XX ID T00760 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Sph factor XX SY GT-IIC; TEF1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SQ IEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIIL SQ SDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQ SQ HMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAY SQ PIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFV SQ HIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQD SQ DAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCE SQ YMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHI SQ YRLVKD XX SC SwissProt #P28347 XX DR EMBL: M63896; HSTEF1(g). DR SwissProt: P28347; TEF1_HUMAN. XX RN [1] RA Kemper B., Jackson P. D., Felsenfeld G. RT Protein-Binding Sites within the 5' DNase I-Hypersensitive RT Region of the Chicken alphaD-Globin Gene RL Mol. Cell. Biol. 7:2059-2069 (1987). RN [2] RA Emerson B. M., Lewis C. D., Felsenfeld G. RT Interaction of specific nuclear factors with the nuclease-hypersensitive RT region of the chicken adult beta-globin gene: nature of the binding domain RL Cell 41:21-30 (1985). XX // AC T00761 XX ID T00761 XX DT 27.01.93 (created); hse. DT 10.01.96 (updated); hiwi. XX FA SRF XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0014; MADS; . XX SZ 67 kDa (SDS) XX SF phosphorylation XX FF binds to serum response element (SRE); FF increases with myoblast differentiation XX IN T00043; ARG RI; yeast, Saccharomyces cerevisiae. IN T00250; Elk-1; human, Homo sapiens. IN T00737; SAP-1a; human, Homo sapiens. IN T01413; Net; mouse, Mus musculus. IN T02128; SAP-1b; human, Homo sapiens. XX MX M00215; V$SRF_C XX BS R00031; CHICK$AAC_03; Quality: 1; chick, Gallus gallus BS R04185; RSV$RSV_08; Quality: 3; RSV, rous sarcoma virus BS R02246; SRF$CONS; Quality: 6 XX RN [1] RA Lee T.-C., Shi Y., Schwartz R. J. RT Displacement of BrdUrd-induced YY1 by serum response RT factor activates skeletal alpha-actin transcription in embryonic myoblasts RL Proc. Natl. Acad. Sci. USA 89:9814-9818 (1992). RN [2] RA Boulden A. M., Sealy L. J. RT Maximal serum stimulation of the c-fos serum response RT element requires both the serum response factor and RT a novel binding factor, SRE-binding protein RL Mol. Cell. Biol. 12:4769-4783 (1992). RN [3] RA Santoro I. M., Yi T.-M., Walsh K. RT Identification of single-stranded-DNA-binding proteins RT that interact with muscle gene elements RL Mol. Cell. Biol. 11:1944-1953 (1991). XX // AC T00762 XX ID T00762 XX DT 27.01.93 (created); hse. DT 10.01.96 (updated); hiwi. XX FA SRF XX OS cat, Felis catus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; carnivora; feliforma; felidae XX CL C0014; MADS; . XX SZ 67 kDa (SDS) XX SF phosphorylation XX FF binds to serum response element (SRE) XX IN T00043; ARG RI; yeast, Saccharomyces cerevisiae. IN T00250; Elk-1; human, Homo sapiens. IN T00737; SAP-1a; human, Homo sapiens. IN T01413; Net; mouse, Mus musculus. IN T02128; SAP-1b; human, Homo sapiens. XX MX M00215; V$SRF_C XX BS R02246; SRF$CONS; Quality: 6 XX // AC T00763 XX ID T00763 XX DT 12.03.93 (created); ewi. DT 09.05.96 (updated); ewi. XX FA SRF XX SY SRFx; XX OS clawed frog, Xenopus laevis OC eukaryota; animalia; metazoa; chordata; vertebrata; OC amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae XX CL C0014; MADS; 4.3.2.0.1. XX SZ 448 AA; 46.1 kDa (cDNA), 54 kDa (SDS) XX SQ MLPSNQAGVAGSGRGLGLARRAGNGAGCPGIRGPGGQYSGSSGSSESGEEEDPPGRGIKR SQ GLNELELPEQGGAAGVVGYPGASGTVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRK SQ TGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSP SQ PRSDPSTDQRMSATGFEETDLTYQVSESDSSGETKDSLKPAFTVTNLPGTSNIQTVPTTS SQ TSMQVSSGHSFPITNYLAPVTSANGTVLKTEGGAMSSGGLMQIPAGFTLMSAGGAVAQQV SQ PVQAIQVHSAAQASPSSDSSSELVQTSSSGTVTLPAAIMTSSVPTTVSGHMMYPSPHAVM SQ YAPTQGLTDGGLAVLNAFSSAPQMQVSHTQEQGGVQQVFLTAPPGTVQIPVSAVQLHQMT SQ VIGQQSSGSNLTELQVVNLDTSNSNKND XX SC SwissProt #P23790 XX FT 39 47 serine-rich region (6/9) FT 98 152 MADS box XX IN T00043; ARG RI; yeast, Saccharomyces cerevisiae. IN T00250; Elk-1; human, Homo sapiens. IN T00737; SAP-1a; human, Homo sapiens. IN T01413; Net; mouse, Mus musculus. IN T02128; SAP-1b; human, Homo sapiens. XX MX M00215; V$SRF_C XX BS R03278; AS$CARG_01; Quality: 4 BS R02246; SRF$CONS; Quality: 6 BS R00048; XENLA$AC_01; Quality: 2; clawed frog, Xenopus laevis BS R00049; XENLA$AC_02; Quality: 2; clawed frog, Xenopus laevis BS R00050; XENLA$AC_03; Quality: 2; clawed frog, Xenopus laevis XX DR EMBL: X56451; XLSRF(r). DR SwissProt: P23790; SRF_XENLA. DR PIR: S15018; S15018. XX RN [1] RA Mohun T. J., Chambers A. E., Towers N., Taylor M. V. RT Expression of genes encoding the transcription factor RT SRF during early development of Xenopus laevis: identification RT of a CArG box-binding activity as SRF RL EMBO J. 10:933-940 (1991). RN [2] RA Taylor M. V. RT A family of muscle gene promoter element (CArG) binding RT activities in Xenopus embryos: CArG/SRE discrimination RT and distribution during myogenesis RL Nucleic Acids Res. 19:2669 (1991). XX // AC T00764 XX ID T00764 XX DT 15.10.92 (created); ewi. DT 09.05.96 (updated); ewi. XX FA SRF XX SY CArG-binding factor; CBF (3) (mouse); p67; p67SRF; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO EBF, factor 1 (mouse) XX CL C0014; MADS; 4.3.2.0.1. XX SZ 508 AA; 51.6 kDa (cDNA), 64, 67 kDa (SDS) XX SQ MLPTQAGAAAALGRGSALGGSLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGPGRLEREA SQ AAAAATTPAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMEIGMVVGGPEASAAA SQ TGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTG SQ TQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATG SQ FEETDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPIT SQ NYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAI SQ QVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPT SQ SGLGDGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTASSGTVQIPVSAVQLHQMAV SQ IGQQAGSSSNLTELQVVNLDTAHSTKSE XX SC SwissProt #P11831 XX FT 206 289 C-terminal phosphorylation sites [18]; FT 242 258 acidic region (6/17) FT 412 508 coactivator binding [19]; FT 414 508 trans-activating domain FT 182 188 beta-strand beta-I [23]; FT 189 193 beta-turn [23]; FT 194 198 beta-strand beta-II [23]; FT 199 208 coil [23]; FT 209 219 alpha-helix alpha-II [23]; FT 143 197 MADS box FT 83 83 phosphorylatable serine FT 77 85 N-terminal phosphorylation sites [17]; FT 132 264 DNA-binding domain (DBD) [4]; FT 153 179 alpha-helix alpha-I [4]; FT 168 222 dimerization [4]; XX SF dimeric DNA-binding [34]; SF co-crystals of DNA-binding domain (132-223) and DNA SF (SRE): two antiparallel amphipathic alpha-helices SF (alpha-I), arranged as coiled coil, approximately SF parallel on the minor groove of the A/T-rich center [23]; SF helices make minor and major groove contacts, N-terminal SF extension form minor groove contacts [23]; SF bound DNA is bent, wrapped around the protein, compressed SF minor groove in the center, widened minor groove in the flanks [23]; SF DNA-binding specificity is located N-terminally to the MADS box [6]; SF truncation of these sequences plus point mutation SF K154E imprints same binding specificity as for RSRFC4 [6]; SF G142E imprints MCM1-like DNA-binding specificity [13]; SF cooperation with ternary complex factor (TCF) enhances SF DNA-binding 50-fold [34]; SF flexible orientation and spacing of both SRF- and TCF-contact sites [2]; SF crucial for TCF-binding: AA 198, 200, 203 [5]; SF N-terminal modification by N-acetylglucosamine [34]; SF phosphorylation enhances DNA-binding up to 13-fold SF due to an altered conformation of the DBD [37]; SF additional multiple phosphorylation at Ser-77, -79, -83, -85, -103 [17]; SF main impact of phosphorylation at 77-85 is enhanced SF association/dissociation kinetics of DNA-binding [16]; SF phosphorylation of Ser-103 affects thermodynamic features SF of DNA-binding [17]; SF Ser-253 phosphorylation by CKII affects transcriptional SF repression by SRF [18]; SF activation domain required in 3T3 cells (414-508) SF is smaller than that for HeLa cells (339-508) [20]; SF possibly two inhibitory domains [20]; XX CP (HeLa) XX FF activator and repressor; FF binding to serum response elements (SRE) and cooperating FF with p62TCF, Elk-1 [34]; FF antagonistic to YY-1 by binding competition [3]; FF induces an optimal TFIID conformation for recruitment FF of the transcription preinitiation complex [15]; FF phosphorylation by casein kinase II most likely involves FF a phospholipase C-pathway [14], [7]; FF gene activation by SRF in response to serum is mediated FF by two pathways, only one dependening on the cooperation with TCF [21]; FF both are sensitive to mutations in the DNA-binding FF domain that do not affect DNA-binding [22]; FF nuclear localization is influenced by a protein kinase FF A-dependent mechanism which does not involve direct FF SRF phosphorylation [24]; XX IN T00043; ARG RI; yeast, Saccharomyces cerevisiae. IN T00250; Elk-1; human, Homo sapiens. IN T00737; SAP-1a; human, Homo sapiens. IN T00764; SRF; human, Homo sapiens. IN T00801; TCF; human, Homo sapiens. IN T01399; TCF; mouse, Mus musculus. IN T01413; Net; mouse, Mus musculus. IN T01414; Net; human, Homo sapiens. IN T02059; K-2; human, Homo sapiens. IN T02128; SAP-1b; human, Homo sapiens. XX MX M00215; V$SRF_C XX BS R03592; AS$ELK1_01; Quality: 6 BS R03593; AS$ELK1_02; Quality: 6 BS R03594; AS$ELK1_03; Quality: 6 BS R03595; AS$ELK1_04; Quality: 6 BS R03596; AS$ELK1_05; Quality: 6 BS R03597; AS$ELK1_06; Quality: 6 BS R03598; AS$ELK1_07; Quality: 6 BS R03599; AS$ELK1_08; Quality: 6 BS R03600; AS$ELK1_09; Quality: 6 BS R03601; AS$ELK1_10; Quality: 6 BS R03602; AS$ELK1_11; Quality: 6 BS R03603; AS$ELK1_12; Quality: 6 BS R03604; AS$ELK1_13; Quality: 6 BS R03606; AS$RSRF4_01; Quality: 6 BS R03605; AS$SRF_01; Quality: 6 BS R03608; AS$SRF_02; Quality: 6 BS R02129; CBF$CONS; Quality: 1 BS R00031; CHICK$AAC_03; Quality: 1; chick, Gallus gallus BS R03495; CHICK$AAC_09; Quality: 1; chick, Gallus gallus BS R03496; CHICK$AAC_10; Quality: 1; chick, Gallus gallus BS R03412; EBV$BZLF1_07; Quality: 1; EBV, Epstein-Barr virus BS R00024; HS$AAC_04; Quality: 1; human, Homo sapiens BS R00142; HS$APOE_01; Quality: 5; human, Homo sapiens BS R00038; HS$BAC_02; Quality: 4; human, Homo sapiens BS R00039; HS$BAC_03; Quality: 4; human, Homo sapiens BS R00040; HS$BAC_04; Quality: 4; human, Homo sapiens BS R00464; HS$CFOS_07; Quality: 1; human, Homo sapiens BS R00466; HS$CFOS_09; Quality: 2; human, Homo sapiens BS R02907; HS$VLC1_01; Quality: 1; human, Homo sapiens BS R00472; MOUSE$CFOS_01; Quality: 4; mouse, Mus musculus BS R03375; MOUSE$CYR61_01; Quality: 1; mouse, Mus musculus BS R01795; MOUSE$EGR1_04; Quality: 1; mouse, Mus musculus BS R01796; MOUSE$EGR1_05; Quality: 1; mouse, Mus musculus BS R01797; MOUSE$EGR1_06; Quality: 1; mouse, Mus musculus BS R00961; MOUSE$KROX_01; Quality: 4; mouse, Mus musculus BS R00037; RAT$BAC_01; Quality: 5; rat, Rattus norvegicus BS R02246; SRF$CONS; Quality: 3 BS R00051; XENLA$ACY_01; Quality: 1; clawed frog, Xenopus laevis BS R03582; XENLA$CFOS_01; Quality: 2; clawed frog, Xenopus laevis BS R03590; XENLA$GAC5C_01; Quality: 1; clawed frog, Xenopus laevis XX DR EMBL: J03161; HSSRF(r). DR SwissProt: P11831; SRF_HUMAN. DR PIR: A31637; A31637. XX RN [1] RA Chavrier P., Janssen-Timmen U., Mattei M.-G., Zerial RA M., Bravo R., Charnay P. RT Structure, Chromosome Location and Expression of the RT Mouse Zinc Finger Gene Krox-20: Multiple Gene Products RT and Coregulation with the Proto-Oncogene c-fos RL Mol. Cell. Biol. 9:787-797 (1989). RN [2] RA Treisman R., Marais R., Wynne J. RT Spatial flexibility in ternary complexes between SRF RT and its accessory proteins RL EMBO J. 11:4631-4640 (1992). RN [3] RA Gualberto A., LePage D., Pons G., Mader S. L., Park RA K., Atchison M. L., Walsh K. RT Functional antagonism between YY1 and the serum response factor RL Mol. Cell. Biol. 12:4209-4214 (1992). RN [4] RA Sharrocks A. D., Gille H., Shaw P. E. RT Identification of amino acids essential for DNA binding RT and dimerization in p67SRF: implications for a novel DNA-binding motif RL Mol. Cell. Biol. 13:123-132 (1993). RN [5] RA Mueller C. G. F., Nordheim A. RT A protein domain conserved between yeast MCM1 and RT human SRF directs ternary complex formation RL EMBO J. 10:4219-4229 (1991). RN [6] RA Sharrocks A. D., von Hesler F., Shaw P. E. RT The identification of elements determining the different RT DNA binding specificities of the MADS box proteins p67SRF and RSRFC4 RL Nucleic Acids Res. 21:215-221 (1993). RN [7] RA Manak J. R., de Bisschop N., Kris R. M., Prywes R. RT Casein kinase II enhances the DNA binding activity of serum response factor RL Genes Dev. 4:955-967 (1990). RN [8] RA Smith J. D., Melian A., Leff T., Breslow J. L. RT Expression of the Human Apolipoprotein E Gene is Regulated RT by Multiple Positive and Negative Elements RL J. Biol. Chem. 263:8300-8308 (1988). RN [9] RA Boxer L. M., Prywes R., Roeder R. G., Kedes L. RT The Sarcomeric Actin CArG-Binding Factor Is Indistinguishable RT from the c-fos Serum Response Factor RL Mol. Cell. Biol. 9:515-522 (1989). RN [10] RA Walsh K. RT Cross-Binding of Factors to Functionally Different RT Promoter Elements in c-fos and Skeletal Actin Genes RL Mol. Cell. Biol. 9:2191-2201 (1989). RN [11] RA Greenberg M. E., Siegfried Z., Ziff E. B. RT Mutation of the c-fos gene dyad symmetry element inhibits RT serum inducibility of transcription in vivo and the RT nuclear regulatory factor binding in vitro RL Mol. Cell. Biol. 7:1217-1225 (1987). RN [12] RA Treisman R. RT Identification and purification of a polypeptide that RT binds to the c-fos serum response element RL EMBO J. 6:2711-2717 (1987). RN [13] RA Nurrish S. J., Treisman R. RT DNA binding specificity determinants in MADS-box transcription factors RL Mol. Cell. Biol. 15:4076-4085 (1995). RN [14] RA Schalasta G., Doppler C. RT Inhibition of c-fos transcription and phosphorylation RT of the serum response factor by an inhibitor of phospholipase RT C-type reactions RL Mol. Cell. Biol. 10:5558-5561 (1990). RN [15] RA Zhu H., Roy A. L., Roeder R. G., Prywes R. RT Serum response factor affects preinitiation complex RT formation by TFIID in vitro RL New Biologist 3:455-464 (1991). RN [16] RA Marais R. M., Hsuan J. J., McGuigan C., Wynne J., Treisman R. RT Casein kinase II phosphorylation increases the rate RT of serum response factor-binding site exchange RL EMBO J. 11:97-105 (1992). RN [17] RA Janknecht R., Hipskind R. A., Houthaeve T., Nordheim A., Stunnenberg H. G. RT Identification of multiple SRF N-terminal phosphorylation RT sites affecting DNA binding properties RL EMBO J. 11:1045-1054 (1992). RN [18] RA Janknecht R., Ernst W. H., Houthaeve T., Nordheim A. RT C-terminal phosphorylation of the serum-response factor RL Eur. J. Biochem. 216:469-475 (1993). RN [19] RA Prywes R., Zhu H. RT In vitro squelching of activated transcription by RT serum response factor: evidence for a common coactivator RT used by multiple transcriptional activators RL Nucleic Acids Res. 20:513-520 (1992). RN [20] RA Johansen F.-E., Prywes R. RT Identification of transcriptional activation and inhibitory RT domains in serum response factor (SRF) by using GAL4-SRF constructs RL Mol. Cell. Biol. 13:4640-4647 (1993). RN [21] RA Johansen F.-E., Prywes R. RT Two pathways for serum regulation of the c-fos serum RT response element require specific sequence elements RT and a minimal domain of serum response factor RL Mol. Cell. Biol. 14:5920-5928 (1994). RN [22] RA Hill C. S., Wynne J., Treisman R. RT Serum-regulated transcription by Serum Response Factor RT (SRF): a novel role for the DNA binding domain RL EMBO J. 13:5421-5432 (1994). RN [23] RA Pellegrini L., Tan S., Richmond T. J. RT Structure of serum response factor core bound to DNA RL Nature 376:490-498 (1995). RN [24] RA Gauthier-Rouviere C., Vandromme M., Lautredou N., RA Cai Q. Q., Girard F., Fernandez A., Lamb N. RT The serum response factor nuclear localization signal: RT general implications for cyclic AMP-dependent protein RT kinase activity in control of nuclear tanslocation RL Mol. Cell. Biol. 15:433-444 (1995). RN [25] RA Frederickson R. M., Micheau M. R., Iwamoto A., Miyamoto N. G. RT 5' flanking and first intron sequences of the human RT beta-actin gene required for efficient promoter activity RL Nucleic Acids Res. 17:253-270 (1989). RN [26] RA Christy B., Nathans D. RT Functional Serum Response Elements Upstream of the RT Growth Factor-Inducible Gene zif268 RL Mol. Cell. Biol. 9:4889-4895 (1989). RN [27] RA Mohun T., Garrett N., Treisman R. RT Xenopus cytoskeletal actin and human c-fos gene promoters RT share a conserved protein-binding site RL EMBO J. 6:667-673 (1987). RN [28] RA Shaw P. E., Frasch S., Nordheim A. RT Repression of c-fos transcription is mediated through p6SRF bound to the SRE RL EMBO J. 8:2567-2574 (1989). RN [29] RA Hayes T. E., Sengupta P., Cochran B. H. RT The human c-fos serum response factor and the yeast RT factors GRM/PRTF have related DNA-binding specificities RL Genes Dev. 2:1713-1722 (1988). RN [30] RA Treisman R. RT Identification of a protein-binding site that mediates RT transcriptional response of the c-fos gene to serum factors RL Cell 46:567-574 (1986). RN [31] RA Schroeter H., Shaw P. E., Nordheim A. RT Purification of intercalator-released p67, a polypeptide RT that interacts specifically with the c-fos serum response element RL Nucleic Acids Res. 15:10145-10158 (1987). RN [32] RA Shaw P. E., Schroeter H., Nordheim A. RT The Ability of a Ternary Complex to Form Over the RT Serum Response Element Correlates with Serum Inducibility RT of the Human c-fos Promoter RL Cell 56:563-572 (1989). RN [33] RA Leung S., Miyamoto N. G. RT Point mutational analysis of the human c-fos serum RT response factor binding site RL Nucleic Acids Res. 17:1177 (1989). RN [34] RA Schroeter H., Mueller C. G. F., Meese K., Nordheim A. RT Synergism in ternary complex formation between the RT dimeric glycoprotein p67SRF, polypeptide p62TCF and RT the c-fos serum response element RL EMBO J. 9:1123-1130 (1990). RN [35] RA Latinkic B. V., O'Brien T. P., Lau L. F. RT Promoter function and structure of the growth factor-inducible RT immediate early gene cyr61 RL Nucleic Acids Res. 19:3261 (1991). RN [36] RA Prywes R., Dutta A., Cromlish J. A., Roeder R. G. RT Phosphorylation of serum response factor, a factor RT that binds to the serum response element of the c-FOS enhancer RL Proc. Natl. Acad. Sci. USA 85:7206-7210 (1988). RN [37] RA Manak J. R., Prywes R. RT Mutation of serum response factor phosphorylation RT sites and the mechanism by which its DNA-binding activity RT is increased by casein kinase II RL Mol. Cell. Biol. 11:3652-3659 (1991). RN [38] RA Hipskind R. A., Rao V. N., Mueller C. G. F., Reddy E. S. P., Nordheim A. RT Ets-related protein Elk-1 is homologous to the c-fos RT regulatory factor p62TCF RL Nature 354:531-534 (1991). XX // AC T00765 XX ID T00765 XX DT 15.10.92 (created); ewi. DT 24.04.96 (updated); ewi. XX FA SRF XX SY CArG-binding factor; CBF (3); p67; p67SRF; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO factor 1, EBF XX CL C0014; MADS; 4.3.2.0.1. XX SZ 67 kDa (SDS) XX FF binds to serum response element (SRE); FF rapid and transient induction of SRF mRNA synthesis FF after serum stimulation (60-480 min, somewhat delayed FF compared with c-fos mRNA: possible hint on SRF role FF in shutoff of c-fos transcription) [1]; FF progressive phosphorylation over 12 h [1]; FF SRF protein half-life >12 h [1]; FF SRF gene activation by SRF alone occurs through a FF PKC-independent pathway, cooperative effect with TCF FF is stimulated by PKC [8]; XX IN T00043; ARG RI; yeast, Saccharomyces cerevisiae. IN T00250; Elk-1; human, Homo sapiens. IN T00737; SAP-1a; human, Homo sapiens. IN T01413; Net; mouse, Mus musculus. IN T02128; SAP-1b; human, Homo sapiens. XX MX M00215; V$SRF_C XX BS R02129; CBF$CONS; Quality: 1 BS R00036; HS$AACS_01; Quality: 4; human, Homo sapiens BS R00021; HS$AAC_01; Quality: 4; human, Homo sapiens BS R00022; HS$AAC_02; Quality: 4; human, Homo sapiens BS R00024; HS$AAC_04; Quality: 1; human, Homo sapiens BS R00026; HS$AAC_05; Quality: 4; human, Homo sapiens BS R00027; HS$AAC_06; Quality: 4; human, Homo sapiens BS R01759; HS$AAC_08; Quality: 4; human, Homo sapiens BS R01757; HS$AAC_12; Quality: 4; human, Homo sapiens BS R00463; HS$CFOS_06; Quality: 3; human, Homo sapiens BS R00464; HS$CFOS_07; Quality: 1; human, Homo sapiens BS R00465; HS$CFOS_08; Quality: 1; human, Homo sapiens BS R00466; HS$CFOS_09; Quality: 2; human, Homo sapiens BS R02907; HS$VLC1_01; Quality: 4; human, Homo sapiens BS R00472; MOUSE$CFOS_01; Quality: 4; mouse, Mus musculus BS R01797; MOUSE$EGR1_06; Quality: 1; mouse, Mus musculus BS R02246; SRF$CONS; Quality: 3 BS R01890; Y$STE3_02; Quality: 4; yeast, Saccharomyces cerevisiae BS R01893; Y$STE6_04; Quality: 4; yeast, Saccharomyces cerevisiae XX RN [1] RA Misra R. P., Rivera V. M., Wang J. M., Fan P.-D., Greenberg M. E. RT The serum response factor is extensively modified RT by phosphorylation following its synthesis in serum-stimulated fibroblasts RL Mol. Cell. Biol. 11:4545-4554 (1991). RN [2] RA Gustafson T. A., Miwa T., Boxer L. M., Kedes L. RT Interactions of Nuclear Proteins with Muscle-Specific RT Regulatory Sequences of the Human Cardiac alpha-Actin Promoter RL Mol. Cell. Biol. 8:4110-4119 (1988). RN [3] RA Boxer L. M., Miwa T., Gustafson T. A., Kedes L. RT Identification and Characterization of a Factor That RT Binds to Two Human Sarcomeric Actin Promoters RL J. Biol. Chem. 264:1284-1292 (1989). RN [4] RA Boxer L. M., Prywes R., Roeder R. G., Kedes L. RT The Sarcomeric Actin CArG-Binding Factor Is Indistinguishable RT from the c-fos Serum Response Factor RL Mol. Cell. Biol. 9:515-522 (1989). RN [5] RA Gustafson T. A., Taylor A., Kedes L. RT DNA bending is induced by a transcription factor that RT interacts with the human c-FOS and alpha-actin promoters RL Proc. Natl. Acad. Sci. USA 86:2162-2166 (1989). RN [6] RA Muscat G. E. O., Gustafson T. A., Kedes L. RT A Common Factor Regulates Skeletal and Cardiac alpha-Actin RT Gene Transcription in Muscle RL Mol. Cell. Biol. 8:4120-4133 (1988). RN [7] RA Gustafson T. A., Kedes L. RT Identification of Multiple Proteins That Interact RT with Functional Regions of the Human Cardiac alpha-Actin Promoter RL Mol. Cell. Biol. 9:3269-3283 (1989). RN [8] RA Graham R., Gilman M. RT Distinct protein targets for signals acting at the RT c-fos serum response element RL Science 251:189-192 (1991). XX // AC T00766 XX ID T00766 XX DT 15.10.92 (created); ewi. DT 22.01.96 (updated); hiwi. XX FA SRF XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0014; MADS; 4.3.2.0.1. XX SF phosphorylation XX FF in vitro and in vivo phosphorylation by casein kinase FF II, leading to induction of c-fos XX IN T00043; ARG RI; yeast, Saccharomyces cerevisiae. IN T00250; Elk-1; human, Homo sapiens. IN T00737; SAP-1a; human, Homo sapiens. IN T01413; Net; mouse, Mus musculus. IN T02128; SAP-1b; human, Homo sapiens. XX MX M00215; V$SRF_C XX BS R02246; SRF$CONS; Quality: 6 XX RN [1] RA Gauthier-Rouviere C., Basset M., Blanchard J.-M., RA Cavadore J.-C., Fernandez A., Lamb N. J. C. RT Casein kinase II induces c-fos expression via the RT serum response element pathway and p67SRF phosphorylation RT in living fibroblasts RL EMBO J. 10:2921-2930 (1991). RN [2] RA Levi B.-Z., Kasik J. W., Burke P. A., Prywes R., Roeder RA R. G., Appella E., Ozato K. RT Neonatal induction of a nuclear protein that binds to the c-fos enhancer RL Proc. Natl. Acad. Sci. USA 86:2262-2266 (1989). XX // AC T00767 XX ID T00767 XX DT 02.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Sry-delta XX SY Serendipity delta; Sry delta; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; . XX SZ 430 AA; 49.7 kDa (gene) XX SQ MDTCFFCGAVDLSDTGSSSSMRYETLSAKVPSSQKTVSLVLTHLANCIQTQLDLKPGARL SQ CRCFQELSDYDTIMVNLMTTQKRLTTQLKGALKSEFEVPESGEDILVEEVEIPQSDVETD SQ ADAEADALFVELVKDQEESDTEIKREFVDEEEEEDDDDDDEFICEDVDVGDSEALYGKSS SQ DGEDRPTKKRVKQECTTCGKVYNSWYQLQKHISEEHSKQPNHICPICGVIRRDEEYLELH SQ MNLHEGKTEKQCRYCPKSFSRPVNTLRHMRSHWDKKKYQCEKCGLRFSQDNLLYNHRLRH SQ EAEENPIICSICNVSFKSRKTFNHHTLIHKENRPRHYCSVCPKSFTERYTLKMHMKTHEG SQ DVVYGVREEAPADEQQVVEELHVDVDESEAAFTVIMSDNDENSGFCLICNTTFENKKELE SQ HHLQFDHDVS XX SC SwissProt #P07664 XX SF 6+1 zinc finger motifs SF acidic region XX BS R03395; DROME$SRYDT_01; Quality: 6; fruit fly, Drosophila melanogaster BS R03396; DROME$SRYDT_02; Quality: 6; fruit fly, Drosophila melanogaster BS R03397; DROME$SRYDT_03; Quality: 6; fruit fly, Drosophila melanogaster BS R03398; DROME$SRYDT_04; Quality: 6; fruit fly, Drosophila melanogaster BS R03400; SRYD$CONS; Quality: 6 XX DR EMBL: X03121; DMSRYG1(g). DR SwissProt: P07664; SRYD_DROME. DR PIR: C23351; C23351. DR Flybase: FBgn0003512; Sry-delta. XX RN [1] RA Payre F., Vincent A. RT Genomic targets of the serendipity beta and delta RT zinc finger proteins and their respective DNA recognition sites RL EMBO J. 10:2533-2541 (1991). RN [2] RA Vincent A., Colot H. V., Rosbash M. RT Sequence and structure of the Serendipity locus of Drosophila melanogaster RL J. Mol. Biol. 186:149-166 (1985). RN [3] RA Noselli St., Payre F., Vincent A. RT Zinc fingers and other domains cooperate in binding RT of Drosophila sry beta and delta proteins at specific chromosomal sites RL Mol. Cell. Biol. 12:724-733 (1992). XX // AC T00768 XX ID T00768 XX DT 02.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Sry h-1 XX SY Pqp; Wdn; Wings-down; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; . XX SZ 868 AA; 95.4 kDa XX SQ MEGGKGEGKRMKEEAPSKKLPPKIYGGDAGTPTKAAHDEILSSLLRINNFDSISSIKDES SQ LDIDLSACVTISSASLVNGNSLSSTDFWRVLDESAQNNTELNLSSDVCRDDLAATSSSTL SQ PSTLTSDNHSSSEFSVTFLRPEPPNAFTNSPFKKTSSSGTSTPVKLSPEQLHQQHQLQMP SQ QSQLLQRKPKLPAATAVRLKVFKEEPPEEKHPPEQVVTKVEVCESELLPPSFTIFQQAKS SQ AESVADRLACRPAASETKPLEVDPAPLHKCLDCNGLLLETPDEVAKHEAAAHRLRLTYRC SQ SECQREFELLAGLKKHLKTHRTEGRKDTWKKCPDCGKCLKLGSMWMHRKIHSDNKKYQCD SQ ICGQKFVQKINLTHHARIHSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGK SQ MYKTERCLKVHNLVHLEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTN SQ FPNWLKHTRRRHKVDHKTGEHLENIPSYCSKKSTTNKAQKAAAAAAAAAAASSAVNPNEL SQ SASSELKAKANLTSTAAPAPAKQARKKKQPQQATLAALGITLPAGTALQQVHPVPLAQQH SQ QQELTTVLVPLAPPAPKQTKAKRERKQLAPKQLQQKPQLLQQGQPQQSSLEPIPAVPQIK SQ KEPVQTQGPFLDLHGLSLTSAEELIMEQALEMEECGLYDAPNANNEMGTSDNAISDSAAA SQ LHFQIKNELPDELLPDDDFLPCKPSDRLACPSLESSPFSSPASMELTAVSCASSVAISTN SQ ALPVRSGNYYLPAFTLNAHGKLSSTGNGVQSVTTSLAQTPSVSMVNVPLLVRSNQMLPSV SQ DTLLFTNQTGGSRFFAGKSATAATPHLT XX SC SwissProt #P15619 XX SF 8 zinc finger motifs SF alanine-rich region XX CP adult ovaries, oocytes XX DR EMBL: M23391; DMDROSOPH(g). DR SwissProt: P15619; SRYC_DROME. DR PIR: A30817; A30817. DR Flybase: FBgn0005642; wdn. XX RN [1] RA Vincent A., Kejzlarova-Lepesant J., Segalat L., Yanicostas RA C., Lepesant J.-A. RT sry h-1, a new Drosophila melanogaster multifingered RT protein gene showing maternal and zygotic expression RL Mol. Cell. Biol. 8:4459-4468 (1988). RN [2] RA Segalat L., Perichon R., Bouly J.-P., Lepesant J.-A. RT The Drosophila pourquoi-pas?/wings-down zinc finger RT protein: oocyte nucleus localization and embryonic requirement RL Genes Dev. 6:1019-1029 (1992). XX // AC T00769 XX ID T00769 XX DT 02.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Sry-beta XX SY Serendipity beta; Sry beta; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; . XX SZ 351 AA; 41.2 kDa (gene) XX SQ MSSTRPFCFVCGKEKSVGVFQLIEGTFKPIKDILKYFEKIINQRLELLPNSAACRDCLEY SQ LFNYDRLVRNLSQVQRQIADALLGCRQVEGKAETKQQAAKRARVQVPAFKIVQATALKEP SQ ERQPGEEDECEEFMKEEMLDEEFQFSEPDDSMPSSEEEFFTETTEIPCHICGEMFSSQEV SQ LERHIKADTCQKSEQATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVL SQ RHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRTYKHHL SQ RTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEKPESAEAKEATVTFF XX SC SwissProt #P07665 XX SF 6 zinc finger motifs SF acidic region XX BS R03390; DROME$SRYBT_01; Quality: 6; fruit fly, Drosophila melanogaster BS R03391; DROME$SRYBT_02; Quality: 6; fruit fly, Drosophila melanogaster BS R03392; DROME$SRYBT_03; Quality: 6; fruit fly, Drosophila melanogaster BS R03393; DROME$SRYBT_04; Quality: 6; fruit fly, Drosophila melanogaster BS R03399; DROME$SRYBT_05; Quality: 6; fruit fly, Drosophila melanogaster BS R03394; SRYB$CONS; Quality: 6 XX DR EMBL: X03121; DMSRYG1(g). DR SwissProt: P07665; SRYB_DROME. DR PIR: A23351; A23351. DR Flybase: FBgn0003511; Sry-beta. XX RN [1] RA Payre F., Vincent A. RT Genomic targets of the serendipity beta and delta RT zinc finger proteins and their respective DNA recognition sites RL EMBO J. 10:2533-2541 (1991). RN [2] RA Vincent A., Colot H. V., Rosbash M. RT Sequence and structure of the Serendipity locus of Drosophila melanogaster RL J. Mol. Biol. 186:149-166 (1985). RN [3] RA Noselli St., Payre F., Vincent A. RT Zinc fingers and other domains cooperate in binding RT of Drosophila sry beta and delta proteins at specific chromosomal sites RL Mol. Cell. Biol. 12:724-733 (1992). XX // AC T00771 XX ID T00771 XX DT 15.10.92 (created); ewi. XX FA beta-factor XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX RN [1] RA Hariharan N., Kelley D. E., Perry R. P. RT Equipotent mouse ribosomal protein promoters have RT a similar architecture that includes internal sequence elements RL Genes Dev. 3:1789-1800 (1989). XX // AC T00772 XX ID T00772 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA STE12 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 688 AA; 78 kDa (gene) XX SQ MKVQITNSRTEEILKVQANNENDEVSKATPGEVEESLRLIGDLKFFLATAPVNWQENQII SQ RRYYLNSGQGFVSCVFWNNLYYITGTDIVKCCLYRMQKFGREVVQKKKFEEGIFSDLRNL SQ KCGIDATLEQPKSEFLSFLFRNMCLKTQKKQKVFFWFSVAHDKLFADALERDLKRESLNQ SQ PSTTKPVNEPALSFSYDSSSDKPLYDQLLQHLDSRRPSSTTKSDNSPPKLESENFKDNEL SQ VTVTNQPLLGVGLMDDDAPESPSQINDFIPQKLIIEPNTLELNGLTEETPHDLPKNTAKG SQ RDEEDFPLDYFPVSVEYPTEENAFDPFPPQAFTPAAPSMPISYDNVNERDSMPVNSLLNR SQ YPYQLSVAPTFPVPPSSSRQHFMTNRDFYSSNNNKEKLVSPSDPTSYMKYDEPVMDFDES SQ RPNENCTNAKSHNSGQQTKQHQLYSNNFQQSYPNGMVPGYYPKMPYNPMGGDPLLDQAFY SQ GADDFFFPPEGCDNNMLYPQTATSWNVLPPQAMQPAPTYVGRPYTPNYRSTPGSAMFPYM SQ QSSNSMQWNTAVSPYSSRAPSTTAKNYPPSTFYSQNINQYPRRRTVGMKSSQGNVPTGNK SQ QSVGKSAKISKPLHIKTSAYQKQYKINLETKARPSAGDEDSAHPDKNKEISMPTPDSNTL SQ VVQSEEGGAHSLEVDTNRRSDKNLPDAT XX SC SwissProt #P13574 XX FT 1 204 DNA-binding domain, STE12 cooperativity FT 1 435 minimal complementing region FT 253 354 transcriptional induction, pheromone-dependent FT phosphorylation FT 383 669 transcriptional activation FT 436 669 MCM1 cooperativity XX FF mediates pheromone-induced transcription, becomes FF phosphorylated and activated upon alpha-pheromone FF treatment without DNA-binding being affected XX IN T00486; MATalpha1; yeast, Saccharomyces cerevisiae. IN T00500; MCM1; yeast, Saccharomyces cerevisiae. IN T01290; MATalpha1; yeast, Kluyveromyces lactis. XX BS R03608; AS$SRF_02; Quality: 6 BS R01842; Y$MFA1_01; Quality: 3; yeast, Saccharomyces cerevisiae BS R01843; Y$MFA2_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01844; Y$MFA2_02; Quality: 3; yeast, Saccharomyces cerevisiae BS R01049; Y$MFAL2_02; Quality: 1; yeast, Saccharomyces cerevisiae BS R01838; Y$STE2_04; Quality: 4; yeast, Saccharomyces cerevisiae BS R01479; Y$TY917_02; Quality: 4; yeast, Saccharomyces cerevisiae XX DR EMBL: X16112; SCSTE12(g). DR EMBL: M24502; SCSTE12A(g). DR SwissProt: P13574; ST12_YEAST. DR PIR: A32583; A32583. DR PIR: A33540; A33540. XX RN [1] RA Mueller C. G. F., Nordheim A. RT A protein domain conserved between yeast MCM1 and RT human SRF directs ternary complex formation RL EMBO J. 10:4219-4229 (1991). RN [2] RA Kirkman-Correia C., Stroke I. L., Fields S. RT Functional domains of the yeast STE12 protein, a pheromone-responsive RT transcriptional activator RL Mol. Cell. Biol. 13:3765-3772 (1993). RN [3] RA Company M., Adler C., Errede B. RT Identification of a Ty1 Regulatory Sequence Responsive to STE7 and STE12 RL Mol. Cell. Biol. 8:2545-2554 (1988). RN [4] RA Errede B., Ammerer G. RT STE12, a protein involved in cell-type-specific transcription RT and signal transduction in yeast, is part of protein-DNA complexes RL Genes Dev. 3:1349-1361 (1989). RN [5] RA Dolan J. W., Kirkman C., Fields S. RT The yeast STE12 protein binds to the DNA sequence RT mediating pheromone induction RL Proc. Natl. Acad. Sci. USA 86:5703-5707 (1989). RN [6] RA Song O.-k., Dolan J. W., Yuan Y.-l. O., Fields S. RT Pheromone-dependent phosphorylation of the yeast STE12 RT protein correlates with transcriptional activation RL Genes Dev. 5:741-750 (1991). XX // AC T00773 XX ID T00773 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA su(f) XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX SQ MSSARDLIKVDIEWGMERLVRAQQVVELRPYDIESWSVMIREAQTRPIHEVRSLYESLVN SQ VFPTTARYWKLYIEMEMRSRYYERVEKLFQRCLVKILNIDLWKLYLTYVKETKSGLSTHK SQ EKMAQAYDFALEKIGMDLHSFSIWQDYIYFLRGVEAVGNYAENQKITAVRRVYQKAVVTP SQ IVGIEQLWKDYIAFEQNINPIISEKMSLERSKDYMNARRVAKELEYHTKGLNRNLPAVPP SQ TLTKEEVKQVELWKRFITYEKSNPLRTEDTALVTRRVMFATEQCLLVLTHHPAVWHQASQ SQ FLDTSARVLTEKGDVQAAKIFADECANILERSINGVLNRNALLYFAYADFEEGRLKYEKV SQ HTMYNKLLQLPDIDPTLVYVQYMKFARRAEGIKSARSIFKKAREDVRSRYHIFVAAALME SQ YYCSKDKEIAFRIFELGLKRFGGSPEYVMCYIDYLSHLNEDNNTRVLFERVLSSGGLSPH SQ KSVEVWNRFLEFESNIGDLSSIVKVERRRSAVFENLKEYEGKETAQLVDRYKFLDLYPCT SQ STELKSIGYAENVGIILNKVGGGAQSQNTGEVETDSEATPPLPRPDFSQMIPFKPRPCAH SQ PGAHPLAGGVFPQPPALAALCATLPPPNSFRGPFVSVELLFDIFMRLNLPDSAPQPNGDN SQ ELSPKIFDLAKSVHWIVDTSTYTGVQHSVTAVPPRRRRLLPGGDDSDDELQTAVPPSHDI SQ YRLRQLKRFAKSN XX SC SwissProt #P25991 XX BS R00626; DROME$GYP_02; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: X62679; DMSUPF(r). DR SwissProt: P25991; SUF_DROME. DR PIR: S22061; S22061. DR Flybase: FBgn0003559; su(f). XX RN [1] RA Mazo A. M., Mizrokhi L. J., Karavanov A. A., Sedkov RA Y. A., Krichevskaja A. A., Ilyin Y. V. RT Suppression in Drosophila: su(Hw) and su(f) gene products RT interact with a region of gypsy (mdg4) regulating RT its transcriptional activity RL EMBO J. 8:903-911 (1989). XX // AC T00774 XX ID T00774 XX DT 15.10.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA su(Hw) XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; . XX SZ 944 AA; 106.3 kDa (gene) XX SQ MSASKEGKEKKGKLLGVENISPPKDKRPATKMKLLNDVGAGEDSEASTTTTTSRTPSNKQ SQ GKRDSVAESRIKILNEEILGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAVETTK SQ IKTSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNG SQ QEIVVTEDDEDLGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLE SQ FCRYDSGYRLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFK SQ TQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKSYACKICGKDFTRS SQ YHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKN SQ CFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAV SQ KEVLNRHMKRHTGERPHKCDECGKSFIRATQLRTHSKTHIRPFPCEQCDEKFKTEKQLER SQ HVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERTDCAI SQ CDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLIS SQ SQTDGNDVVVREFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTDEAGVKPEAKKEE SQ AQVSPVVKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILTEEDIKLKENVGKLIDMLV SQ DPPILKKYGWPNAPEETVLCKVIENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHN SQ DSIKSLLNNFPIDDVIEYVLGDEDQDEGGLDKDNEDNESHSGDEEAVSVTGETKKNEIKE SQ KPEKKEVSAKSEKKEIVGKAVDKDNTEEVVRENKKKPVGEQEKA XX SC SwissProt #P08970 XX SF 12 zinc finger motifs SF acidic region XX FF activator of gypsy gene XX BS R00625; DROME$GYP_01; Quality: 6; fruit fly, Drosophila melanogaster BS R02385; SUHW$CONS; Quality: 6 XX DR EMBL: Y00228; DMSUHW(g). DR SwissProt: P08970; SUHW_DROME. DR PIR: S01909; S01909. DR Flybase: FBgn0003567; su(Hw). XX RN [1] RA Mazo A. M., Mizrokhi L. J., Karavanov A. A., Sedkov RA Y. A., Krichevskaja A. A., Ilyin Y. V. RT Suppression in Drosophila: su(Hw) and su(f) gene products RT interact with a region of gypsy (mdg4) regulating RT its transcriptional activity RL EMBO J. 8:903-911 (1989). RN [2] RA Parkhurst S. M., Harrison D. A., Remington M. P., RA Spana C., Kelley R. L., Coyne R. S., Corces V. G. RT The Drosophila su(Hw) gene, which controls the phenotypic RT effect of the gypsy transposable element, encodes RT a putative DNA-binding protein RL Genes Dev. 2:1205-1215 (1988). RN [3] RA Spana C., Harrison D. A., Corces V. G. RT The Drosophila melanogaster suppressor of Hairy-wing RT protein binds to specific sequences of the gypsy retrotransposon RL Genes Dev. 2:1414-1423 (1988). XX // AC T00775 XX ID T00775 XX DT 03.12.92 (created); ewi. DT 04.03.97 (updated); ewi. XX FA SWI4 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 1.1.6.0.2. XX SZ 1093 AA; 123.8 kDa (cDNA), 120-130 kDa (SDS) XX SQ MPFDVLISNQKDNTNHQNITPISKSVLLAPHSNHPVIEIATYSETDVYECYIRGFETKIV SQ MRRTKDDWINITQVFKIAQFSKTKRTKILEKESNDMQHEKVQGGYGRFQGTWIPLDSAKF SQ LVNKYEIIDPVVNSILTFQFDPNNPPPKRSKNSILRKTSPGTKITSPSSYNKTPRKKNSS SQ SSTSATTTAANKKGKKNASINQPNPSPLQNLVFQTPQQFQVNSSMNIMNNNDNHTTMNFN SQ NDTRHNLINNISNNSNQSTIIQQQKSIHENSFNNNYSATQKPLQFFPIPTNLQNKNVALN SQ NPNNNDSNSYSHNIDNVINSSNNNNNGNNNNLIIVPDGPMQSQQQQQHHHEYLTNNFNHS SQ MMDSITNGNSKKRRKKLNQSNEQQFYNQQEKIQRHFKLMKQPLLWQSFQNPNDHHNEYCD SQ SNGSNNNNNTVASNGSSIEVFSSNENDNSMNMSSRSMTPFSAGNTSSQNKLENKMTDQEY SQ KQTILTILSSERSSDVDQALLATLYPAPKNFNINFEIDDQGHTPLHWATAMANIPLIKML SQ ITLNANALQCNKLGFNCITKSIFYNNCYKENAFDEIISILKICLITPDVNGRLPFHYLIE SQ LSVNKSKNPMIIKSYMDSIILSLGQQDYNLLKICLNYQDNIGNTPLHLSALNLNFEVYNR SQ LVYLGASTDILNLDNESPASIMNKFNTPAGGSNSRNNNTKADRKLARNLPQKNYYQQQQQ SQ QQQPQNNVKIPKIIKTQHPDKEDSTADVNIAKTDSEVNESQYLHSNQPNSTNMNTIMEDL SQ SNINSFVTSSVIKDIKSTPSKILENSPILYRRRSQSISDEKEKAKDNENQVEKKKDPLNS SQ VKTAMPSLESPSSLLPIQMSPLGKYSKPLSQQINKLNTKVSSLQRIMGEEIKNLDNEVVE SQ TESSISNNKKRLITIAHQIEDAFDSVSNKTPINSISDLQSRIKETSSKLNSEKQNFIQSL SQ EKSQALKLATIVQDEESKVDMNTNSSSHPEKQEDEEPIPKSTSETSSPKNTKADAKFSNT SQ VQESYDVNETLRLATELTILQFKRRMTTLKISEAKSKINSSVKLDKYRNLIGITIENIDS SQ KLDDIEKDLRANA XX SC SwissProt #P25302 XX FT 836 1094 SWI6-binding FT 523 526 first TPLH repeat FT 644 647 second TPLH repeat FT 36 155 DNA-binding domain [5]; FT 721 763 leucine zipper (VL6) XX SF 2 TPLH repeats, important for interation with non-SWI6 proteins SF several N/Q-rich clusters are scattered over the molecule SF together with SWI6, it forms the factor SBF in which SF it is the main DNA-binding moiety [4]; SF moreover, it is an essential component of DSC1 [3]; SF ankyrin-repeat-like region of homology with SWI4 and cdc10 [6]; XX FF mediates cell-cycle dependent transcription of HO FF gene and START-specific transcription [2]; XX IN T01013; SWI6; yeast, Saccharomyces cerevisiae. XX BS R03735; Y$CLN2_01; Quality: 6; yeast, Saccharomyces cerevisiae BS R00719; Y$HO_02; Quality: 3; yeast, Saccharomyces cerevisiae BS R00720; Y$HO_03; Quality: 3; yeast, Saccharomyces cerevisiae BS R03752; Y$HO_05; Quality: 6; yeast, Saccharomyces cerevisiae XX DR EMBL: X51606; SCSW14(g). DR SwissProt: P25302; SWI4_YEAST. DR PIR: S07106; S07106. XX RN [1] RA Sidorova J., Breeden L. RT Analysis of the SWI4/SWI6 protein complex, which directs RT G1/S-specific transcription in Saccharomyces cerevisiae RL Mol. Cell. Biol. 13:1069-1077 (1993). RN [2] RA Andrews B. J., Moore L. A. RT Interaction of the yeast Swi4 and Swi6 cell cycle RT regulatory proteins in vitro RL Proc. Natl. Acad. Sci. USA 89:11852-11856 (1992). RN [3] RA Lowndes N. F., Johnson A. L., Breeden L., Johnston L. H. RT SWI6 protein is required for transcription of the RT periodically expressed DNA synthesis genes in budding yeast RL Nature 357:505-508 (1992). RN [4] RA Dirick L., Moll T., Auer H., Nasmyth K. RT A central role for SWI6 in modulating cell cycle Start-specific RT transcription in yeast RL Nature 357:508-513 (1992). RN [5] RA Primig M., Sockanathan S., Auer H., Nasmyth K. RT Anatomy of a transcription factor important for the RT start of the cell cycle in Saccharomyces cerevisiae RL Nature 358:593-597 (1992). RN [6] RA Andrews B. J., Herskowitz I. RT The yeast SWI4 protein contains a motif present in RT developmental regulators and is part of a complex RT involved in cell-cycle-dependent transcription RL Nature 342:830-833 (1989). XX // AC T00776 XX ID T00776 XX DT 28.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA SWI5 XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL C0001; CH; 2.3.2.1.1. XX SZ 709 AA XX SQ MDTSNSWFDASKVQSLNFDLQTNSYYSNARGSDPSSYAIEGEYKTLATDDLGNILNLNYG SQ ETNEVIMNEINDLNLPLGPLSDEKSVKVSTFSELIGNDWQSMNFDLENNSREVTLNATSL SQ LNENRLNQDSGMTVYQKTMSDKPHDEKKISMADNLLSTINKSEINKGFDRNLGELLLQQQ SQ QELREQLRAQQEANKKLELELKQTQYKQQQLQATLENSDGPQFLSPKRKISPASENVEDV SQ YANSLSPMISPPMSNTSFTGSPSRRNNRQKYCLQRKNSSGTVGPLCFQELNEGFNDSLIS SQ PKKIRSNPNENLSSKTKFITPFTPKSRVSSATSNSANITPNNLRLDFKINVEDQESEYSE SQ KPLGLGIELLGKPGPSPTKSVSLKSASVDIMPTIPGSVNNTPSVNKVSLSSSYIDQYTPR SQ GKQLHFSSISENALGINAATPHLKPPSQQARHREGVFNDLDPNVLTKNTDNEGDDNEENE SQ PESRFVISETPSPVLKSQSKYEGRSPQFGTHIKEINTYTTNSPSKITRKLTTLPRGSIDK SQ YVKEMPDKTFECLFPGCTKTFKRRYNIRSHIQTHLEDRPYSCDHPGCDKAFVRNHDLIRH SQ KKSHQEKAYACPCGKKFNREDALVVHRSRMICSGGKKYENVVIKRSPRKRGRPRKDGTSS SQ VSSSPIKENINKDHNGQLMFKLEDQLRRERSYDGNGTGIMVSPMKTNQR XX SC SwissProt #P08153 XX SF 3 zinc finger motifs XX FF cell-cycle regulated activator of HO, nuclear entry only at onset of G1; FF enhanced DNA-binding affinity through cooperative effects with GRF10; FF no direct interaction with GRF10 in the absence of DNA XX BS R02114; Y$HO_04; Quality: 2; yeast, Saccharomyces cerevisiae BS R03861; Y$HO_09; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: X06978; SCSW15(g). DR SwissProt: P08153; SWI5_YEAST. DR PIR: S00342; TWBYS5. DR PDB: 1zfd; SWI5 ZINC FINGER DOMAIN 2 YEAST. XX RN [1] RA Brazas R. M., Stillman D. J. RT The Swi5 zinc-finger and Grf10 homeodomain proteins RT bind DNA cooperatively at the yeast HO promoter RL Proc. Natl. Acad. Sci. USA 90:11237-11241 (1993). RN [2] RA Nagai K., Nakaseko Y., Nasmyth K., Rhodes D. RT Zinc-finger motifs expressed in E. coli and folded RT in vitro direct specific binding to DNA RL Nature 332:284-286 (1988). RN [3] RA Stillman D. J., Bankier A. T., Seddon A., Groehout E., Nasmyth K. A. RT Characterization of a transcription factor involved RT in mother cell specific transcription of the yeast HO gene RL EMBO J. 7:485-494 (1988). RN [4] RA Nasmyth K., Adolf G., Lydall D., Seddon A. RT The identification of a second cell cycle control RT on the HO promoter in yeast: Cell cycle regulation of SWI5 nuclear entry RL Genes Dev. 62:631-647 (1990). RN [5] RA Moll T., Tebb G., Surana U., Robitsch H., Nasmyth K. RT The role of phosphorylation and the CDC28 protein RT kinase in cell cycle-regulated nuclear import of the RT S. cerevisiae transcription factor SWI5 RL Cell 66:743-758 (1991). RN [6] RA Dohrmann P. R., Butler G., Tamai K., Dorland S., Greene RA J. R., Thiele D. J., Stillman B. RT Parallel pathways of gene regulation: Homologous regulators RT SWI5 and ACE2 differentially control transcription of HO and chitinase RL Genes Dev. 6:93-104 (1992). XX // AC T00777 XX ID T00777 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA TAB XX SY TFIID; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX HO B factor, TAB (human) XX BS R00757; DROME$HSP70_07; Quality: 6; fruit fly, Drosophila melanogaster BS R00774; DROME$HSP83_02; Quality: 6; fruit fly, Drosophila melanogaster XX DR Flybase: FBgn0003687; Tbp. XX RN [1] RA Wu C. RT Two protein-binding sites in chromatin implicated RT in the activation of heat-shock genes RL Nature 309:229-234 (1984). XX // AC T00778 XX ID T00778 XX DT 15.10.92 (created); ewi. DT 19.02.94 (updated); dhawale & lane. XX FA TAF XX SY GFI; SUF; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 147 kDa XX FF activator, controls genes of mitochondrial function, FF cell growth, transcription and translation XX BS R02579; GFI$CONS; Quality: 6 BS R00201; Y$CSII_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R00203; Y$CSVIII_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R00204; Y$CSVIII_02; Quality: 4; yeast, Saccharomyces cerevisiae BS R00202; Y$CSVI_01; Quality: 4; yeast, Saccharomyces cerevisiae BS R00254; Y$CYC1_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R00255; Y$CYC1_02; Quality: 4; yeast, Saccharomyces cerevisiae BS R01211; Y$PHO5_05; Quality: 4; yeast, Saccharomyces cerevisiae BS R02578; Y$RP3_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01336; Y$RPS33_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R01339; Y$RPTCM_01; Quality: 4; yeast, Saccharomyces cerevisiae XX RN [1] RA Hamil K. G., Nam H. G., Fried H. M. RT Constitutive Transcription of Yeast Ribosomal Protein RT Gene TCM1 Is Promoted by Uncommon cis- and trans-Acting Elements RL Mol. Cell. Biol. 8:4328-4341 (1988). RN [2] RA Dorsman J. C., van Heeswijk W. C., Grivell L. A. RT Identification of two factors which bind to the upstream RT sequences of a number of nuclear genes coding for RT mitochondrial proteins and to genetic elements important RT for cell division in yeast RL Nucleic Acids Res. 16:7287-7301 (1988). RN [3] RA Dorsman J. C., Doorenbosch M. M., Maurer C. T. C., RA de Winde J. H., Mager W. H., Planta J. R., Grivell L. A. RT An ARS/silencer binding factor also activates two RT ribosomal protein genes in yeast RL Nucleic Acids Res. 17:4917 (1989). XX // AC T00779 XX ID T00779 XX DT 14.04.93 (created); ewi. DT 16.05.97 (updated); hiwi. XX FA TAF-125 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 97-125 kDa (SDS) XX FF part of TFIID complex XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX RN [1] RA Zhou Q., Boyer T. G., Berk A. J. RT Factors (TAFs) required for activated transcription RT interact with TATA box-binding protein conserved core domain RL Genes Dev. 7:180-187 (1993). RN [2] RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J. RT Holo-TFIID supports transcriptional stimulation by RT diverse activators and from a TATA-less promoter RL Genes Dev. 6:1964-1974 (1992). RN [3] RA Timmers H. T. M., Meyers R. E., Sharp P. A. RT Composition of transcription factor B-TFIID RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992). XX // AC T00780 XX ID T00780 XX DT 14.04.93 (created); ewi. XX FA TAF-170 XX SY TAF-172; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 170-172 kDa (SDS) XX FF part of B-TFIID complex (not in D-TFIID); FF constituent of TFIIIB XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX RN [1] RA Timmers H. T. M., Meyers R. E., Sharp P. A. RT Composition of transcription factor B-TFIID RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992). RN [2] RA Taggart A. K. P., Fisher T. S., Pugh B. F. RT The TATA-binding protein and associated factors are RT components of pol III transcription factor TFIIIB RL Cell 71:1015-1028 (1992). XX // AC T00781 XX ID T00781 XX DT 14.04.93 (created); ewi. DT 16.05.97 (updated); hiwi. XX FA TAF-250 XX SY CCG1; p250; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 1872AA; 212.7 kDa (cDNA), 250 kDa (SDS) XX SQ MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD SQ ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE SQ SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV SQ DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR SQ FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP SQ PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS SQ GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED SQ VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW SQ EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI SQ LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ SQ PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG SQ EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG SQ ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF SQ VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES SQ SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD SQ AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG SQ EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL SQ SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST SQ EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA SQ SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT SQ KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL SQ KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG SQ TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD SQ PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP SQ SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD SQ DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH SQ KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT SQ AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT SQ PEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSA SQ IQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISY SQ GSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFH SQ SIAGDSDLDSDE XX SC translated from EMBL #D90359 XX FT 1 177 NF-kappaB homology region [11]; FT 23 204 acidic region (34/182) FT 146 351 mot found in TAFII250delta [10]; FT 178 198 insert not found in CCG1 [10]; FT 671 686 sigma4.1 homology region [11]; FT 966 1146 SWI4 homology region [11]; FT 1000 1010 sigma2.1 homology region [11]; FT 1120 1210 binding of TFIIF-alpha [16]; FT 1197 1276 HMG homology box [10], [11]; FT 1211 1239 sigma4.2 homology region [11]; FT 1365 1485 direct repeat 1 FT 1397 1467 bromo domain FT 1486 1607 direct repeat 2 FT 1520 1590 bromo domain XX FF tight association with TBP, role in assembly of the TFIID complex XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX DR EMBL: X07024; HSCCG1(r). DR EMBL: D90359; HSCCG1B(r). DR SwissProt: P21675; CCG1_HUMAN. DR PIR: A40262; A40262. DR PIR: S03005; S03005. XX RN [1] RA Dubrovskaya V., Lavigne A.-C., Davidson I., Acker J., Staub A., Tora L. RT Distinct domains of hTAFII100 are requireed for functional RT interactions with transcription factor TFIIbeta (RAP30) RT and incorporation into the TFIID complex RL EMBO J. 15:3702-3712 (1996). RN [2] RA Shao Z., Ruppert S., Robbins P. D. RT The retinoblastoma-susceptibility gene product binds RT directly to the human TATA-binding protein-associated factor TAFII250 RL Proc. Natl. Acad. Sci. USA 92:3115-3119 (1995). RN [3] RA Chiang C.-M., Roeder R. G. RT Cloning of an instrinsic human TFIID subunit that RT interacts with multiple transcriptional activators RL Science 267:531-536 (1995). RN [4] RA Tansey W. P., Ruppert S., Tjian R., Herr W. RT Multiple regions of TBP participate in the response RT to transcriptional activators in vivo RL Genes Dev. 8:2756-2769 (1994). RN [5] RA Pugh B. F., Tjian R. RT Transcription from a TATA-less promoter requires a RT multisubunit TFIID complex RL Genes Dev. 5:1935-1945 (1991). RN [6] RA Zhou Q., Boyer T. G., Berk A. J. RT Factors (TAFs) required for activated transcription RT interact with TATA box-binding protein conserved core domain RL Genes Dev. 7:180-187 (1993). RN [7] RA Weinzierl R. O. J., Ruppert S., Dynlacht B. D., Tanese N., Tjian R. RT Cloning and expression of Drosophila TAFII60 and human RT TAFII70 reveal conserved interactions with other subunits of TFIID RL EMBO J. 12:5303-5309 (1993). RN [8] RA Jacq X., Brou C., Lutz Y., Davidson I., Chambon P., Tora L. RT Human TAFII30 is present in a distinct TFIID complex RT and is required for transcriptional activation by the estrogen receptor RL Cell 79:107-117 (1994). RN [9] RA Weinzierl R. O. J., Dynlacht B. D., Tjian R. RT Largest subunit of Drosophila transcription factor RT IID directs assembly of a complex containing TBP and a coactivator RL Nature 362:511-517 (1993). RN [10] RA Ruppert S., Wang E. H., Tjian R. RT Cloning and expression of human TAFII250: a TBP-associated RT factor implicated in cell-cycle regulation RL Nature 362:175-179 (1993). RN [11] RA Hisatake K., Hasegawa S., Takada R., Nakatani Y., Horikoshi M., Roeder R. G. RT The p250 subunit of native TATA box-binding factor RT TFIID is the cell-cycle regulatory protein CCG1 RL Nature 362:179-181 (1993). RN [12] RA Sekiguchi T., Miyata T., Nishimoto T. RT Molecular cloning of the cDNA of human X chromosomal RT gene (CCG1) which complement the temperature sensitive RT G1 mutants, tsBN462 and ts13 of BHK cells RL EMBO J. 7:1683-1687 (1988). RN [13] RA Haynes S. R., Dollard C., Winston F., Beck S., Trowsdale J., Dawid I. B. RT The bromodomain: A conserved sequence found in human, RT Drosophila and yeast proteins RL Nucleic Acids Res. 20:2603-2603 (1992). RN [14] RA Sekiguchi T., Nohiro Y., Nakamura Y., Hisamoto N., Nishimoto T. RT The human CCG1 gene, essential for progression of RT the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein RL Mol. Cell. Biol. 11:3317-3325 (1991). RN [15] RA Wang E., Tjian R. RT Promoter-selective transcriptional defect in cell RT cycle mutant ts13 rescued by hTAFII250 RL Science 263:811-814 (1993). RN [16] RA Ruppert S., Tjian R. RT Human TAFII250 interacts with RAP74: implications RT for RNA polymerase II initiation RL Genes Dev. 9:2747-2755 (1995). RN [17] RA Takada R., Nakatani Y., Hoffmann A., Kokubo T., Hasegawa RA S., Roeder R. G., Horikoshi M. RT Identification of human TFIID components and direct RT interaction between a 250-kDa polypeptide and the RT TATA box-binding protein (TFIIDtau) RL Proc. Natl. Acad. Sci. USA 89:11809-11813 (1992). RN [18] RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J. RT Holo-TFIID supports transcriptional stimulation by RT diverse activators and from a TATA-less promoter RL Genes Dev. 6:1964-1974 (1992). RN [19] RA Timmers H. T. M., Meyers R. E., Sharp P. A. RT Composition of transcription factor B-TFIID RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992). XX // AC T00782 XX ID T00782 XX DT 14.04.93 (created); ewi. DT 16.05.97 (updated); hiwi. XX FA TAF-50 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 349 AA; 40.3 kDa (cDNA); 46-50 kDa (SDS), 55kDa (SDS) XX SQ MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVDR SQ VPLASKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVASTDPKASK SQ KKDKDKEKKFIWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVRTR SQ WEIIAEDETKEAENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQD SQ EEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQNQIDNMKGKLQETQDRAK SQ RQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK XX SC translated from EMBL # U18062 XX FT 38 113 interaction with upstream activators [2]; FT 139 249 interaction with TAF-230 [2]; XX CP ubiquitous [2]; XX FF part of TFIID complex XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX DR EMBL: U18062; HS18062(r). DR SwissProt: Q13036; Q13036. XX RN [1] RA Dubrovskaya V., Lavigne A.-C., Davidson I., Acker J., Staub A., Tora L. RT Distinct domains of hTAFII100 are requireed for functional RT interactions with transcription factor TFIIbeta (RAP30) RT and incorporation into the TFIID complex RL EMBO J. 15:3702-3712 (1996). RN [2] RA Chiang C.-M., Roeder R. G. RT Cloning of an instrinsic human TFIID subunit that RT interacts with multiple transcriptional activators RL Science 267:531-536 (1995). RN [3] RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J. RT Holo-TFIID supports transcriptional stimulation by RT diverse activators and from a TATA-less promoter RL Genes Dev. 6:1964-1974 (1992). RN [4] RA Timmers H. T. M., Meyers R. E., Sharp P. A. RT Composition of transcription factor B-TFIID RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992). XX // AC T00783 XX ID T00783 XX DT 14.04.93 (created); ewi. DT 16.05.97 (updated); hiwi. XX FA TAF-78 XX SY TAF-70; TAF-80; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 677 AA (alpha), 726 AA (beta), 667 AA (gamma); 72.7 kDa (alpha), SZ 77.9 kDa (beta), 71.5 kDa (gamma), 70 kDa (SDS), 80 kDa (SDS) XX SQ MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHM SQ GKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINT SQ PLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKG SQ KGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRA SQ EALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKY SQ VHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFT SQ KSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGA SQ DHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLCSQVVKARAQAALQAQQVNRT SQ TLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIV SQ MSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGP SQ GSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGT SQ PKANGSQPNSGSPQPAP XX SC SwissProt #P49848 XX FT 1 100 binding to TAF-31 and TAF-20 [2]; FT 203 276 binding to TAF-250 and TAFIIF-alpha [2]; FT 377 505 binding to TBP and TFIIE-alpha [2]; XX FF part of TFIID complex XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX DR EMBL: U31659; HS316591(r). DR EMBL: L25444; HSTAF2A(r). DR SwissProt: P49848; T2D4_HUMAN. XX RN [1] RA Weinzierl R. O. J., Ruppert S., Dynlacht B. D., Tanese N., Tjian R. RT Cloning and expression of Drosophila TAFII60 and human RT TAFII70 reveal conserved interactions with other subunits of TFIID RL EMBO J. 12:5303-5309 (1993). RN [2] RA Hisatake K., Ohta T., Takada R., Guermah M., Horikoshi RA M., Nakatani Y., Roeder R. G. RT Evolutionary conservation of human TATA-binding-polypeptide-associated RT factors TAFII31 and TAFII80 and interactions of TAFII80 RT with other TAFs and with general transcription factors RL Proc. Natl. Acad. Sci. USA 92:8195-8199 (1995). RN [3] RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J. RT Holo-TFIID supports transcriptional stimulation by RT diverse activators and from a TATA-less promoter RL Genes Dev. 6:1964-1974 (1992). RN [4] RA Timmers H. T. M., Meyers R. E., Sharp P. A. RT Composition of transcription factor B-TFIID RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992). XX // AC T00784 XX ID T00784 XX DT 14.04.93 (created); ewi. DT 16.05.97 (updated); hiwi. XX FA TAF-95 XX SY TAF-100; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 799 AA; 86.7 kDa (cDNA), 95 kDa (SDS), 100 kDa (SDS) XX SQ MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGD SQ GGTPKPTVAVSAAAPAGAAPVPAAAPDAGAPHDRQTLLAVLQFLRQSKLREAEEALRREA SQ GLLEETVAGAGAPGEVDSAGAEVTSALLSRVTASAPGPAAPDPPGTGASGATVVSGSASG SQ PAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECSLDCHRAELSQLF SQ YPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDL SQ RTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLA SQ GEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPN SQ APPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGSDCLPSICFYTFLNVYQGLTAVDVTD SQ DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY SQ GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF SQ VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN SQ CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS SQ RDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSPVV SQ HLHFTRRNLVLAAGAYSPQL XX SC translated from EMBL # X95525 XX FT 282 392 important for TAFII100 incorporation into TFIID [2]; FT 458 739 six WD-40 repeats XX FF part of TFIID complex XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX DR EMBL: X95525; HSTAFII10(r). DR SwissProt: Q15542; Q15542. XX RN [1] RA Dubrovskaya V., Lavigne A.-C., Davidson I., Acker J., Staub A., Tora L. RT Distinct domains of hTAFII100 are requireed for functional RT interactions with transcription factor TFIIbeta (RAP30) RT and incorporation into the TFIID complex RL EMBO J. 15:3702-3712 (1996). RN [2] RA Zhou Q., Boyer T. G., Berk A. J. RT Factors (TAFs) required for activated transcription RT interact with TATA box-binding protein conserved core domain RL Genes Dev. 7:180-187 (1993). RN [3] RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J. RT Holo-TFIID supports transcriptional stimulation by RT diverse activators and from a TATA-less promoter RL Genes Dev. 6:1964-1974 (1992). RN [4] RA Timmers H. T. M., Meyers R. E., Sharp P. A. RT Composition of transcription factor B-TFIID RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992). XX // AC T00785 XX ID T00785 XX DT 25.01.93 (created); ewi. XX FA TAF-I XX SY Tax activation factor I; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 52 kDa (SDS) XX FF involved in Tax-mediated activation of HTLV-I; FF different from CREB or c-Jun XX BS R00777; HT1$HTLV1_01; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R03997; HT1$HTLV1_20; Quality: 4; HTLV-I, human T-cell lymphotropic virus type I XX RN [1] RA Xu Y.-L., Adya N., Siores E., Gao Q., Giam C.-Z. RT Cellular factors involved in transcription and Tax-mediated RT trans-activation directed by the TGACGT motifs in RT human T-cell leukemia virus type I promoter RL J. Biol. Chem. 265:20285-20292 (1990). XX // AC T00786 XX ID T00786 XX DT 25.01.93 (created); ewi. XX FA TAF-II XX SY Tax activation factor II; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 46 kDa (SDS) XX FF involved in Tax-mediated activation of HTLV-I; FF different from CREB or c-Jun XX BS R00777; HT1$HTLV1_01; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R03997; HT1$HTLV1_20; Quality: 4; HTLV-I, human T-cell lymphotropic virus type I XX RN [1] RA Xu Y.-L., Adya N., Siores E., Gao Q., Giam C.-Z. RT Cellular factors involved in transcription and Tax-mediated RT trans-activation directed by the TGACGT motifs in RT human T-cell leukemia virus type I promoter RL J. Biol. Chem. 265:20285-20292 (1990). XX // AC T00787 XX ID T00787 XX DT 15.04.93 (created); ewi. XX FA TAF-L XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF part of B-TFIID / TFIIIB complex XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. XX RN [1] RA Taggart A. K. P., Fisher T. S., Pugh B. F. RT The TATA-binding protein and associated factors are RT components of pol III transcription factor TFIIIB RL Cell 71:1015-1028 (1992). XX // AC T00788 XX ID T00788 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA T-Ag XX OS SV40, simian virus 40 OC viridae; ds-DNA nonenveloped viruses; papovaviridae; polyomaviruses XX CL C0001; CH; 2.3.5.0.1. XX SZ 708 AA; 100 kDa XX SQ MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYK SQ KMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADS SQ QHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYS SQ VTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDP SQ FSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFE SQ MCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQM SQ LTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKR SQ YWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGG SQ ESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFTPGIVTMNEFSVPKTLQAR SQ FVKQIDFRAKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWK SQ ERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHE SQ TGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET XX SC SwissProt #P03070 XX SF 1 zinc finger motif XX IN T00656; Oct-6; mouse, Mus musculus. IN T00671; p53; human, Homo sapiens. IN T01806; p53; mouse, Mus musculus. XX BS R01234; PA$PY_16; Quality: 6; Py, polyoma virus BS R01238; PA$PY_20; Quality: 6; Py, polyoma virus BS R01241; PA$PY_23; Quality: 6; Py, polyoma virus BS R01242; PA$PY_24; Quality: 6; Py, polyoma virus BS R01243; PA$PY_25; Quality: 6; Py, polyoma virus BS R01244; PA$PY_26; Quality: 6; Py, polyoma virus BS R01823; SV$ORI_01; Quality: 6; SV40, simian virus 40 BS R01369; SV$SV40_01; Quality: 6; SV40, simian virus 40 BS R01370; SV$SV40_02; Quality: 6; SV40, simian virus 40 BS R01372; SV$SV40_04; Quality: 6; SV40, simian virus 40 XX DR EMBL: V01380; SV40XX(g). DR EMBL: J02400; SVCG(g). DR SwissProt: P03070; TALA_SV40. DR PIR: B03631; TVVPT4. XX RN [1] RA Loeber G., Stenger J. E., Ray S., Parsons R. E., Anderson RA M. E., Tegtmeyer P. RT The zinc finger region of simian virus 40 large T RT antigen is needed for hexamer assembly and origin melting RL J. Virol. 65:3167-3174 (1991). RN [2] RA Mitchell P., Wang C., Tjian R. RT Positive and Negative Regulation of Transcription RT In Vitro: Enhancer-Binding Protein AP-2 Is Inhibited by SV40 T Antigen RL Cell 50:847-861 (1987). RN [3] RA Cowie A., Kamen R. RT Multiple Binding Sites for Polyomavirus Large T Antigen RT Within Regulatory Sequences of Polyomavirus DNA RL J. Virol. 52:750-760 (1984). RN [4] RA Dilworth S. M., Cowie A., Kamen R. I., Griffin B. E. RT DNA binding activity of polyoma virus large tumor antigen RL Proc. Natl. Acad. Sci. USA 81:1941-1945 (1984). RN [5] RA DeLucia A. L., Lewton B. A., Tjian R., Tegtmeyer P. RT Topography of Simian Virus 40 A Protein-DNA Complexes: RT Arrangement of Pentanucleotide Interaction Sites at RT the Origin of Replication RL J. Virol. 46:143-150 (1983). RN [6] RA McVey D., Strauss M., Gluzman Y. RT Properties of the DNA-Binding Domain of the Simian Virus 40 Large T Antigen RL Mol. Cell. Biol. 9:5525-5536 (1989). XX // AC T00789 XX ID T00789 XX DT 03.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Tll XX SY Tailless; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0002; CC (rec); 2.1.2.10.2. XX SZ 452 AA XX SQ MQSSEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKR SQ SIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRH SQ MAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPS SQ AAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHL SQ FKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANR SQ EIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTG SQ SGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKV SQ SSFTIEELFFRKTIGDITIVRLISDMYSQRKI XX SC SwissProt #P18102 XX FF repressor of Krueppel expression; FF activator of hairy in stripe 7 XX BS R02274; DROME$KR_07; Quality: 2; fruit fly, Drosophila melanogaster BS R02276; DROME$KR_09; Quality: 2; fruit fly, Drosophila melanogaster BS R02277; DROME$KR_10; Quality: 2; fruit fly, Drosophila melanogaster BS R02279; DROME$KR_12; Quality: 2; fruit fly, Drosophila melanogaster BS R02281; DROME$KR_14; Quality: 2; fruit fly, Drosophila melanogaster BS R02282; DROME$KR_15; Quality: 2; fruit fly, Drosophila melanogaster BS R02285; DROME$KR_18; Quality: 2; fruit fly, Drosophila melanogaster XX DR EMBL: M34639; DMTLL(r). DR SwissProt: P18102; TLL_DROME. DR PIR: A35602; A35602. DR Flybase: FBgn0003720; tll. XX RN [1] RA Hoch M., Gerwin N., Taubert H., Jaeckle H. RT Competition for overlapping sites in the regulatory RT region of the Drosophila gene Krueppel RL Science 256:94-97 (1992). RN [2] RA Riddihough G., Ish-Horowicz D. RT Individual stripe regulatory elements in the Drosophila RT hairy promoter respond to maternal, gap, and pair-rule genes RL Genes Dev. 5:840-854 (1991). XX // AC T00790 XX ID T00790 XX DT 15.03.93 (created); ewi. DT 15.05.97 (updated); ewi. XX FA Tal-1 XX SY SCL; T-cell acute lymphocytic leukemia-1 protein; TCL5; Tal-1alpha; SY pp42-TAL1; stem-cell leukemia protein; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0010; bHLH; 1.2.4.1.1.1. XX SZ 331 AA; 34.3 kDa (cDNA) XX SQ MTERPPSEAARSDPQLEGRDAAEASMAPPHLVLLNGVAKETSRAAAAEPPVIELGARGGP SQ GGGPAGGGGAARDLKGRDAATAEARHRVPTTELCRPPGPAPAPAPASVTAELPGDGRMVQ SQ LSPPALAAPAAPGRALLYSLSQPLASLGSGFFGEPDAFPMFTTNNRVKRRPSPYEMEITD SQ GPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLA SQ KLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQDVLSPNSSCGSSLDGAAS SQ PDSYTEEPAPKHTARSLHPAMLPAADGAGPR XX SC SwissProt #P17542 XX FT 117 175 major trans-activating domain [14]; FT 188 199 basic region FT 200 240 helix-loop-helix domain FT 263 274 glycine-rich region (11/12) FT 176 176 alternative translation initiation codon (TAL-1beta) XX SF N-terminally truncated forms arise from alternative SF translation initiation at Met-26 (p39) or Met-176 (p22) [12]; SF the eight exons give rise to several splice variants [6]; SF no homodimers, no intrinsic DNA-binding capability, SF but DNA-binding heterodimers with class A bHLH factors [19], [3]; SF binding sites contain one E-box-like half (AACAG) SF and one which is contacted by Tal-1 (ATGGT) [3]; SF Tal-1 peptides can be phosphorylated at serine residues [17]; SF multiple trans-activating domains within 1-175 [14]; SF Tal-1 complexes with LIM-proteins RBTN2 in erythroid SF cells and RBTN1 in T-ALL cells [15]; SF RBTN-interactions depend on an intact bHLH domain SF and occur simultaneously with E47 heterodimerization [2]; SF specific for the bHLH domains of the Tal-1/Tal-2/Lyl-2 SF family and for RBTN LIM proteins [2]; XX CP erythroid cells [13], early hematopoietic tissues, fetal liver [4]; XX FF activator [14]; FF positive regulator of erythroid differentiation [13]; FF TAL1 gene rearrangements in patients with T-cell acute FF lymphoblastic leukemia [11]; FF most observed breakpoints are between exons Ia and FF Ib within the 5'-UTR of the transcribed region [7]; FF after chromosomal translocation or deletion leading FF to inappropriate expression, it may promoter erythroleukemia [17]; FF a C-terminally truncated variant found in a Jurkat FF cell subline appears to cause premature apoptosis FF after serum deprivation [18]; XX IN T00204; E12; human, Homo sapiens. IN T00207; E47; human, Homo sapiens. IN T00405; IEBP1; rat, Rattus norvegicus. IN T00433; ITF-2; human, Homo sapiens. IN T00674; E47; rat, Rattus norvegicus. IN T01788; E47; mouse, Mus musculus. XX MX M00066; V$TAL1ALPHAE47_01 XX BS R04157; AS$TAL1_01; Quality: 2 BS R00850; MOUSE$IGH_16; Quality: 6; mouse, Mus musculus BS R04158; MOUSE$IGH_59; Quality: 2; mouse, Mus musculus XX DR EMBL: M29038; HSSCL(r). DR EMBL: M61103; HSSCL1(g). DR EMBL: M61104; HSSCL2(g). DR EMBL: M61105; HSSCL3(g). DR EMBL: M63572; HSSCL4(g). DR EMBL: M63576; HSSCL5(g). DR EMBL: M63584; HSSCL6(g). DR EMBL: M63589; HSSCL7(g). DR EMBL: M61108; HSSCLA(g). DR EMBL: X51990; HSTAL1AA(r). DR EMBL: X58621; HSTAL1D(g). DR EMBL: X58622; HSTAL1E(g). DR SwissProt: P17542; SCL_HUMAN. DR PIR: A34519; A34519. DR PIR: A36358; A36358. XX RN [1] RA Hsu H.-L., Huang L., Tsan J. T., Funk W., Wright W. RA E., Hu J.-S., Kingston R. E., Baer R. RT Preferred sequences for DNA recognition by the TAL1 RT helix-loop-helix proteins RL Mol. Cell. Biol. 14:1256-1265 (1994). RN [2] RA Wadman I., Li J., Bash R. O., Forster A., Osada H., Rabbitts T. H., Baer R. RT Specific in vivo association between the bHLH and RT LIM proteins implicated in human T cell leukemia RL EMBO J. 13:4831-4839 (1994). RN [3] RA Hsu H.-L., Huang L., Tsan J. T., Funk W., Wright W. RA E., Hu J.-S., Klingston R. E., Baer R. RT Preferred sequence for DNA recognition by the TAL1 helix-loop-helix proteins RL Mol. Cell. Biol. 14:1256-1265 (1991). RN [4] RA Begley C. G., Aplan P. D., Denning S. M., Haynes B. RA F., Waldmann T. A., Kirsch I. R. RT The gene SCL is expressed during early hematopiesis RT and encodes a differentiation-related DNA-binding motif RL Proc. Natl. Acad. Sci. USA 86:10128-10132 (1989). RN [5] RA Chen Q., Cheng J. T., Tsai L. H., Schneider N., Buchanan RA G., Carroll A., Crist W., Ozanne B., Siciliano M. J., Baer R. RT The tal gene undergoes chromosome translocation in RT T cell leukemia and potentially encodes a helix-loop-helix protein RL EMBO J. 9:415-424 (1990). RN [6] RA Aplan P. D., Begley C. G., Bertness V., Nussmeier RA M., Ezquerra A., Coligan J., Kirsch I. R. RT The SCL gene is formed from a transcriptionally complex locus RL Mol. Cell. Biol. 10:6426-6435 (1990). RN [7] RA Chen Q., Yang C. Y. C., J, T, Tsan , Xia Y., Ragab RA A. H., Peiper S. C., Carroll A., Baer R. RT Coding sequences of the tal-1 gene are disrupted by RT chromosome translocation in human T cell leukemia RL J. Exp. Med. 172:1403-1408 (1990). RN [8] RA Begley C. G., Aplan P. D., Davey M. P., Nakahara K., RA Tchorz K., Kurtzberg J., Hershfield M., Haynes B. RA F., Cohen D. I., Waldmann T. A., Kirsch I. R. RT Chromosomal translocation in a human leukemic stem-cell RT line disrupts the T-cell antigen receptor delta-chain RT diversity region and results in a previously unreported fusion transcript RL Proc. Natl. Acad. Sci. USA 86:2031-2035 (1989). RN [9] RA Aplan P. D., Lombardi D. P., Reaman G. H., Sather RA H. N., Hammond G. D., Kirsch I. R. RT Involvement of the putative hematopoitic transcription RT factor SCL in T-cell acute lymphoblastic leukemia RL Blood 79:1327-1333 (1992). RN [10] RA Aplan P. D., Lombardi D. P., Ginsberg A. M., Cossman RA J., Bertness V. L., Kirsch I. R. RT Disruption of the human SCL locus by 'illegitime' V(D)J recombinase activity RL Science 250:1426-1429 (1990). RN [11] RA Brown L., Cheng J.-T., Chen Q., Siciliano M. J., Christ RA W., Buchanan G., Baer R. RT Site-specific recombination of the tal-1 gene is a RT common occurence in human T cell leukemia RL EMBO J. 9:3343-3351 (1990). RN [12] RA Whitelaw M. L., Goettlicher M., Gustafsson J. A., Poelinger L. RT Definition of a novel ligand binding domain of a nuclear RT bHLH receptor: co-localization of ligand and hsp90 RT binding activities within the regulable inactivation RT domain of the dioxin receptor RL EMBO J. 12:4169-4179 (1993). RN [13] RA Carver L. A., Hogenesch J. B., Bradfield C. A. RT Tissue specific expression of the rat Ah-receptor and ARNT mRNAs RL Nucleic Acids Res. 22:3038-3044 (1994). RN [14] RA Reick M., Robertson R. W., Pasco D. S., Fagan J. B. RT Down-regulation of nuclear aryl hydrocarbon receptor RT DNA-binding and transactivation functions: requirement RT for a labile or inducible factor RL Mol. Cell. Biol. 14:5653-5660 (1994). RN [15] RA Antonsson C., Whitelaw M. L., McGuire J., Gustafsson J. -A., Poellinger L. RT Distinct roles of the molecular chaperone hsp90 in RT modulating dioxin receptor function via the basic RT helix-loop-helix and PAS domains RL Mol. Cell. Biol. 15:756-765 (1995). RN [16] RA Fujisawa-Sehara A., Sogawa K., Yamane M., Fuji-Kurijama Y. RT Characterization of xenobiotic response elements upstream RT from the drug-metabolizing cytochrome P450c gene: RT a similarity to glucocorticoid regulatoty elements RL Nucleic Acids Res. 15:4179-4191 (1987). RN [17] RA Burbach K. M., Poland A., Bradfield C. A. RT Cloning of the Ah-receptor cDNA reveals a distinctive-ligand-activated RT transcription factor RL Proc. Natl. Acad. Sci. USA 89:8185-8189 (1992). RN [18] RA Leroy-Viard K., Vinit M.-A., Lecointe N., Jouault RA H., Hibner U., Romeo P.-H., Mathieu-Mahul D. RT Loss of TAL-1 protein activity induces premature apoptosis RT of Jurkat leukemic T cells upon medium depletion RL EMBO J. 14:2341-2349 (1995). RN [19] RA Hsu H.-L., Cheng J.-T., Chen Q., Baer R. RT Enhancer-binding activity of the tal-1 oncoprotein RT in association with the E47/E12 helix-loop-helix proteins RL Mol. Cell. Biol. 11:3037-3042 (1991). XX // AC T00791 XX ID T00791 XX DT 15.10.92 (created); ewi. DT 07.07.94 (updated); hwi; ewi. XX FA TAR factor XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 68 kDa (SDS) XX BS R00707; HIV1$HIV1_14; Quality: 6; HIV-1, human immunodeficiency virus type 1 XX DR EMBL: M60801; HSTRBP(r). XX RN [1] RA Garcia J. A., Wu F. K., Mitsuyasu R., Gaynor R. B. RT Interaction of cellular proteins involved in the transcriptional RT regulation of the human immunodeficiency virus RL EMBO J. 6:3761-3770 (1987). RN [2] RA Marciniak R. A., Garcia-Blanco M. A., Sharp P. A. RT Identification and characterization of a HeLa nuclear RT protein that specifically binds to the trans-activation-response RT (TAR) element of human immunodeficiency virus RL Proc. Natl. Acad. Sci. USA 87:3624-3628 (1990). XX // AC T00792 XX ID T00792 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA tat XX OS HIV-1, human immunodeficiency virus type 1 OC viridae; ss-RNA enveloped viruses; positive strand OC RNA viruses; retroviridae; lentivirinae XX SF zinc ion-dependent XX BS R02421; HIV1$HIV1_25; Quality: 6; HIV-1, human immunodeficiency virus type 1 XX RN [1] RA Cordingley M. G., LaFemina R. L., Callahan P. L., RA Condra J. H., Sardana V. V., Graham D. J., Nguyen RA T. M., LeGrow K., Gotlib L., Schlabach A. J., Colonno R. J. RT Sequence-specific interaction of Tat protein and Tat RT peptides with the transactivation-responsive sequence RT element of human immunodeficiency virus type 1 in vitro RL Proc. Natl. Acad. Sci. USA 87:8985-8989 (1990). XX // AC T00793 XX ID T00793 XX DT 09.12.92 (created); ewi. DT 23.10.94 (updated); ewi. XX FA Tax XX OS HTLV-I, human T-cell lymphotropic virus type I OC viridae; ss-RNA enveloped viruses; positive strand OC RNA viruses; retroviridae; oncovirinae; type C oncovirus OC group; mammalian type C oncoviruses XX FF viral activator; FF promotes dimerization of bZIP transcription factors; FF acc. to ref. 1440: only with CREB, but not with ATF-1 or ATF-3 XX IN T00163; CREB; human, Homo sapiens. IN T00164; CREB; rat, Rattus norvegicus. IN T00167; CRE-BP1; human, Homo sapiens. IN T00968; ATF-1; human, Homo sapiens. IN T01304; ATF-1; mouse, Mus musculus. IN T01940; IkappaB-gamma; mouse, Mus musculus. XX MX M00114; V$TAXCREB_01 MX M00115; V$TAXCREB_02 XX BS R04240; AS$TAXCREB_01; Quality: 2 BS R04241; AS$TAXCREB_02; Quality: 2 BS R04242; AS$TAXCREB_03; Quality: 2 BS R00777; HT1$HTLV1_01; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R00779; HT1$HTLV1_03; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R00780; HT1$HTLV1_04; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R02069; HT1$HTLV1_07; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R03997; HT1$HTLV1_20; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I XX RN [1] RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP RT proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [2] RA Adya N., Zhao L.-J., Huang W., Boros I., Giam C.-Z. RT Expansion of CREB's DNA recognition specificity by RT Tax results from interaction with Ala-Ala-Arg at positions RT 282-284 near the conserved DNA-binding domain of CREB RL Proc. Natl. Acad. Sci. USA 91:5642-5646 (1994). RN [3] RA Giam C.-Z., Xu Y.-L. RT HTLV-I Tax Gene Product Activates Transcription via RT Pre-existing Cellular Factors and cAMP Responsive Element RL J. Biol. Chem. 264:15236-15241 (1989). XX // AC T00794 XX ID T00794 XX DT 27.01.93 (created); hse. DT 16.05.97 (updated); hiwi. XX FA TBP XX SY TFIID; TFIIDtau; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL ; ; 4.5.1.0.1. XX SZ 339 AA; 38-43 kDa (SDS), 37.7 kDa (cDNA) XX SQ MDQNNSLPPYAQGLASPQGAMTPGIPLFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQ SQ QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQ SQ LFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDL SQ KTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARV SQ VQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRI SQ VLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT XX SC SwissProt #P20226 XX FT 55 95 glutamine-rich region FT 166 225 direct repeat I FT 202 272 contacts to PU.1, E1A FT 256 319 direct repeat II FT 202 272 contact region to PU.1, E1A (basic region) [10]; FT 220 271 contact region to p53 [6]; FT 273 339 essential for TAFII250 contact [23]; XX CP ubiquitous XX FF is part of TFIID, SL1, and TFIIIB; FF binds as a monomer, but in association with TAFs; FF bends DNA; FF alone functional on TATA-containing pol III promoters, FF on TATA-less pol III promoters only as B-TFIID complex XX IN T00068; BRF1; yeast, Saccharomyces cerevisiae. IN T00168; c-Rel; human, Homo sapiens. IN T00182; DBF4; human, Homo sapiens. IN T00197; Dr1; human, Homo sapiens. IN T00530; NC1; human, Homo sapiens. IN T00531; NC2; human, Homo sapiens. IN T00641; Oct-1; human, Homo sapiens. IN T00647; Oct-2; human, Homo sapiens. IN T00671; p53; human, Homo sapiens. IN T00702; PU.1; mouse, Mus musculus. IN T00703; Pu.1; chick, Gallus gallus. IN T00759; Sp1; human, Homo sapiens. IN T00779; TAF-125; human, Homo sapiens. IN T00780; TAF-170; human, Homo sapiens. IN T00781; TAF-250; human, Homo sapiens. IN T00782; TAF-50; human, Homo sapiens. IN T00783; TAF-78; human, Homo sapiens. IN T00784; TAF-95; human, Homo sapiens. IN T00787; TAF-L; human, Homo sapiens. IN T00815; TFIIA; yeast, Saccharomyces cerevisiae. IN T00817; TFIIA; human, Homo sapiens. IN T00818; TFIIB; human, Homo sapiens. IN T00819; TFIIB; yeast, Saccharomyces cerevisiae. IN T00894; Vmw65; HSV-1, herpes simplex virus type 1. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00923; Zta; EBV, Epstein-Barr virus. IN T01268; TAF-170; yeast, Saccharomyces cerevisiae. IN T01508; PTF; human, Homo sapiens. IN T01542; E2F-1; human, Homo sapiens. IN T01680; PTFgamma; human, Homo sapiens. IN T01681; PTFdelta; human, Homo sapiens. IN T02068; PU.1; human, Homo sapiens. XX MX M00216; V$TATA_C MX M00252; V$TATA_01 XX BS R01732; AD$E1B_04; Quality: 6; adenovirus BS R02688; AD$E2AE1_21; Quality: 6; adenovirus type 5 BS R03165; AD$IVA2_03; Quality: 2; adenovirus BS R00998; AD$MLP_13; Quality: 6; adenovirus BS R01001; AD$MLP_16; Quality: 6; adenovirus BS R03702; AS$E2TBP_01; Quality: 6; HPV-18, human papilloma virus type 18 BS R03703; AS$E2TBP_02; Quality: 6; HPV-18, human papilloma virus type 18 BS R03182; EBV$BHLF1_05; Quality: 6; EBV, Epstein-Barr virus BS R00705; HIV1$HIV1_12; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R03701; HPV$HPV18_06; Quality: 6; HPV-18, human papilloma virus type 18 BS R03158; HS$DHR_04; Quality: 6; human, Homo sapiens BS R03167; HS$GFAP_02; Quality: 6; human, Homo sapiens BS R00770; HS$HSP70_11; Quality: 6; human, Homo sapiens BS R03171; HS$U6SN_01; Quality: 6; human, Homo sapiens BS R04010; MOUSE$ADA_06; Quality: 2; mouse, Mus musculus BS R03160; MOUSE$IRF1_02; Quality: 6; mouse, Mus musculus BS R03159; MOUSE$RPL32_06; Quality: 6; mouse, Mus musculus BS R03157; SV$MLP_02; Quality: 6; SV40, simian virus 40 BS R02247; TBP$CONS; Quality: 6 XX DR EMBL: M55654; HSTFIID(r). DR EMBL: X54993; HSTFIIDX(r). DR SwissProt: P20226; TF2D_HUMAN. DR PIR: A34830; A34830. DR PIR: A34831; A34831. XX RN [1] RA Reinberg D., Horikoshi M., Roeder R. G. RT Factors involved in specific transcription by mammalian RT RNA polymerase II. Functional analysis of initiation RT factors IIA and IID and identification of a new factor RT operating at sequences downstream of the initiation site RL J. Biol. Chem. 262:3322-3330 (1987). RN [2] RA van Dyke M. W., Sawadogo M. RT DNA-binding and transcriptional properties of human RT transcription factor TFIID after mild proteolysis RL Mol. Cell. Biol. 10:3415-3420 (1990). RN [3] RA Zhu H., Roy A. L., Roeder R. G., Prywes R. RT Serum response factor affects preinitiation complex RT formation by TFIID in vitro RL New Biologist 3:455-464 (1991). RN [4] RA Chen X., Farmer G., Zhu H., Prywes R., Prives C. RT Cooperative DNA binding of p53 TFIID (TBP): a possible RT mechanism for transcriptional activation RL Genes Dev. 7:1837-1849 (1993). RN [5] RA Martin D. W., Munoz R. M., Subler M. A., Deb S. RT p53 binds to the TATA-binding protein-TATA complex RL J. Biol. Chem. 268:13062-13067 (1993). RN [6] RA Liu X., Miller C. W., Koeffler P. H., Berk A. J. RT The p53 activation domain binds the TATA box-binding RT polypeptide in holo-TFIID, and a neighboring p53 domain RT inhibits transcription RL Mol. Cell. Biol. 13:3291-3300 (1993). RN [7] RA Lescure A., Lutz Y., Eberhard D., Jacq X., Krol A., RA Grummt I., Davidson I., Chambon P., Tora L. RT The N-terminal domain of the human TATA-binding protein RT plays a role in transcription from TATA-containing RT RNA polymerase II and III promoters RL EMBO J. 13:1166-1175 (1994). RN [8] RA Comai L., Zomerdijk J. C. B. M., Beckmann H., Zhou S., Admon A., Tjian R. RT Reconstitution of transcription factor SL1: exclusive RT binding of TBP by SL1 or TFIID subunits RL Science 266:1966-1972 (1994). RN [9] RA Dubrovskaya V., Lavigne A.-C., Davidson I., Acker J., Staub A., Tora L. RT Distinct domains of hTAFII100 are requireed for functional RT interactions with transcription factor TFIIbeta (RAP30) RT and incorporation into the TFIID complex RL EMBO J. 15:3702-3712 (1996). RN [10] RA Lee W. S., Kao C. C., Bryant G. O., Liu X., Berk A. J. RT Adenovirus E1A activation domain binds the basic repeat RT in the TATA box transcription factor RL Cell 67:365-376 (1991). RN [11] RA Meisterernst M., Roy A. L., Lieu H. M., Roeder R. G. RT Activation of class II gene transcription by regulatory RT factors is potentiated by a novel activity RL Cell 66:981-993 (1991). RN [12] RA Nash H. A., Granston A. E. RT Similarity between the DNA-binding domains of IHF protein and TFIID protein RL Cell 67:1037-1038 (1991). RN [13] RA Kelleher III R. J., Flanagan P. M., Chasman D. I., RA Ponticelli A. S., Struhl K., Kornberg R. D. RT Yeast and human TFIIDs are interchangeable for the RT response to acidic transcriptional activators in vitro RL Genes Dev. 6:296-303 (1992). RN [14] RA Clark M. E., Lieberman P. M., Berk A. J., Dasgupta A. RT Direct cleavage of human TATA-binding protein by poliovirus RT protease 3C in vivo and in vitro RL Mol. Cell. Biol. 13:1232-1237 (1993). RN [15] RA Brou C., Chaudhary S., Davidson I., Lutz Y., Wu J., RA Egly J.-M., Tora L., Chambon P. RT Distinct TFIID complexes mediate the effect of different RT transcriptional activators RL EMBO J. 12:489-499 (1993). RN [16] RA Chiang C.-M., Ge H., Wang Z., Hoffmann A., Roeder R. G. RT Unique TATA-binding protein-containing complexes and RT cofactors involved in transcription by RNA polymerases II and III RL EMBO J. 12:2749-2762 (1993). RN [17] RA Rigby P. W. J. RT Three in one and one in three: it all depends on TBP RL Cell 72:7-10 (1993). RN [18] RA White R. J., Rigby P. W. J., Jackson S. P. RT The TATA-binding protein is a general transcription RT factor for RNA polymerase III RL Cell 103:1-7 (1992). RN [19] RA Tansey W. P., Ruppert S., Tjian R., Herr W. RT Multiple regions of TBP participate in the response RT to transcriptional activators in vivo RL Genes Dev. 8:2756-2769 (1994). RN [20] RA Rowlands T., Baumann P., Jackson S. P. RT The TATA-binding protein: a general transcription RT factor in eukaryotes and archaebacteria RL Science 264:1326-1329 (1994). RN [21] RA Pugh B. F., Tjian R. RT Transcription from a TATA-less promoter requires a RT multisubunit TFIID complex RL Genes Dev. 5:1935-1945 (1991). RN [22] RA Segall J., Matsui T., Roeder R. G. RT Mutiple factors are required for the accurate transcription RT of purified genes by RNA polymerase III RL J. Biol. Chem. 255:11986-11991 (1980). RN [23] RA Zhou Q., Boyer T. G., Berk A. J. RT Factors (TAFs) required for activated transcription RT interact with TATA box-binding protein conserved core domain RL Genes Dev. 7:180-187 (1993). RN [24] RA Weinzierl R. O. J., Ruppert S., Dynlacht B. D., Tanese N., Tjian R. RT Cloning and expression of Drosophila TAFII60 and human RT TAFII70 reveal conserved interactions with other subunits of TFIID RL EMBO J. 12:5303-5309 (1993). RN [25] RA Comai L., Tanese N., Tjian R. RT The TATA-binding protein and associated factors are RT integral components of the RNA polymerase I transcription factor, SL1 RL Cell 68:965-976 (1992). RN [26] RA Jacq X., Brou C., Lutz Y., Davidson I., Chambon P., Tora L. RT Human TAFII30 is present in a distinct TFIID complex RT and is required for transcriptional activation by the estrogen receptor RL Cell 79:107-117 (1994). RN [27] RA Hagemeier C., Bannister A. J., Cook A., Kouzarides T. RT The activation domain of transcription factor PU.1 RT binds the retinoblastoma (RB) protein and the transcription RT factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB RL Proc. Natl. Acad. Sci. USA 90:1580-1584 (1993). RN [28] RA Truant R., Xiao H., Ingles C. J., Greenblatt J. RT Direct interaction between the transcriptional activation RT domain of human p53 and the TATA box-binding protein RL J. Biol. Chem. 268:2284-2287 (1993). RN [29] RA Timmers H. T. M., Meyers R. E., Sharp P. A. RT Composition of transcription factor B-TFIID RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992). RN [30] RA Wiley S. R., Kraus R. J., Mertz J. E. RT Functional binding of the TATA box binding component RT of transcription factor TFIID to the -30 region of TATA-less promoters RL Proc. Natl. Acad. Sci. USA 89:5814-5818 (1992). RN [31] RA Taggart A. K. P., Fisher T. S., Pugh B. F. RT The TATA-binding protein and associated factors are RT components of pol III transcription factor TFIIIB RL Cell 71:1015-1028 (1992). RN [32] RA Lobo S. M., Tanaka M., Sullivan M. L., Hernandez N. RT A TBP complex essential for transcription from TATA-less RT but not TATA-containing RNA polymerase III promoters RT is part of the TFIIIB fraction RL Cell 71:1029-1040 (1992). RN [33] RA Kao C. C., Liebermann P. M., Schmidt M. C., Zhou Q., Pei R., Berk A. J. RT Cloning of a transcriptionally active human TATA binding factor RL Science 248:1646-1650 (1990). RN [34] RA Hoffmann A., Sinn E., Yamamoto T., Wang J., Roy A., RA Horikoshi M., Roeder R. G. RT Highly conserved core domain and unique N terminus RT with presumptive regulatory motifs in a human TATA factor (TFIID) RL Nature 346:387-390 (1990). RN [35] RA Peterson M. G., Tanese N., Pugh B. F., Tjian R. RT Functional domains and upstream activation properties RT of cloned human TATA binding protein RL Science 248:1625-1630 (1990). RN [36] RA Nakatani Y., Horikoshi M., Brenner M., Yamamoto T., RA Besnard F., Roeder R. G., Freese E. RT A downstream initiation element required for efficient RT TATA box binding and in vitro function of TFIID RL Nature 348:86-88 (1990). RN [37] RA Safer B., Reinberg D., Jacob W. F., Maldonado E., RA Carcamo J., Garfinkel S., Cohen R. RT Interaction of CAP sequence site binding factor and RT transcription factor IID preceding and following binding RT to the adenovirus 2 major late promoter RL J. Biol. Chem. 266:10989-10994 (1991). RN [38] RA Lobo S. M., Lister J., Sullivan M. L., Hernandez N. RT The cloned RNA polymerase II transcription factor RT IID selects RNA polymerase III to transcribe the human U6 gene in vitro RL Genes Dev. 5:1477-1489 (1991). RN [39] RA Kambadur R., Culotta V., Hamer D. RT Cloned yeast and mammalian transcription factor TFIID RT gene products support basal but not activated metallothionein RT gene transcription RL Proc. Natl. Acad. Sci. USA 87:9168-9142 (1990). RN [40] RA Stringer K. F., Ingles C. J., Greenblatt J. RT Direct and selective binding of an acidic transcriptional RT activation domain to the TATA-box factor TFIID RL Nature 345:783-786 (1990). RN [41] RA Horikoshi M., Bertuccioli C., Takada R., Wang C. K., RA Yamamoto T., Roeder R. G. RT Transcription factor TFIID induces DNA bending upon RT binding to the TATA element RL Proc. Natl. Acad. Sci. USA 89:1060-1064 (1992). RN [42] RA Liebermann P. M., Berk A. J. RT The Zta trans-activator protein stabilizes TFIID association RT with promoter DNA by direct protein-protein interaction RL Genes Dev. 5:2441-2454 (1991). RN [43] RA Garcia J. A., Ou S.-H. I., Wu F., Lusis A. J., Sparkes R. S., Gaynor R. B. RT Cloning and chromosomal mapping of a human immunodeficiency RT virus 1 TATA element modulatory factor RL Proc. Natl. Acad. Sci. USA 89:9372-9376 (1992). RN [44] RA Timmers H. T. M., Sharp P. A. RT The mammalian TFIID protein is present in two functionally RT distinct complexes RL Genes Dev. 5:1946-1956 (1991). RN [45] RA Wefald F. C., Devlin B. H., Williams S. RT Functional heterogeneity of mammalian TATA-box sequences RT revealed by interaction with a cell-specific enhancer RL Nature 344:260-262 (1990). RN [46] RA Maldonado E., Ha I., Cortes P., Weis L., Reinberg D. RT Factors involved in specific transcription by mammalian RT RNA polymerase II: role of transcription factors IIA, RT IID, and IIB during formation of a transcription-competent complex RL Mol. Cell. Biol. 10:6335-6347 (1990). RN [47] RA Tamura T., Sumita K., Fujino I., Aoyama A., Horikoshi RA M., Hoffmann A., Roeder R. G., Muramatsu M., Mikoshiba K. RT Striking homology of the 'variable' N-terminal as RT well as the 'conserved core' domains of the mouse RT and human TATA-factors (TFIID) RL Nucleic Acids Res. 19:3861-3865 (1991). RN [48] RA Greenblatt J. RT Roles of TFIID in transcriptional initiation by RNA polymerase II RL Cell 66:1067-1070 (1991). XX // AC T00795 XX ID T00795 XX DT 16.11.92 (created); ewi. DT 05.06.97 (updated); hiwi. XX FA TBP XX SY SPT15; TFIID; TFIIDtau; yBTF1; XX OS fission yeast, Schizosaccharomyces pombe OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 4.5.1.0.1. XX SZ 231 AA; 25.4 kDa (gene) XX SQ MDFALPTTASQASAFMNNSSLTFPVLPNANNEATNETADSGDAEVSKNEGVSGIVPTLQN SQ IVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKSTALIFASGKMVVLGGKSE SQ DDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDVKFPIRLEGLAYSHGTFSSYEPEL SQ FPGLIYRMVKPKVVLLIFVSGKIVLTGAKVREEIYQAFEAIYPVLSEFRKH XX SC SwissProt #P17871 XX FT 58 134 direct repeat I FT 148 225 direct repeat II XX IN T00068; BRF1; yeast, Saccharomyces cerevisiae. IN T00182; DBF4; human, Homo sapiens. IN T00197; Dr1; human, Homo sapiens. IN T00530; NC1; human, Homo sapiens. IN T00531; NC2; human, Homo sapiens. IN T00702; PU.1; mouse, Mus musculus. IN T00759; Sp1; human, Homo sapiens. IN T00779; TAF-125; human, Homo sapiens. IN T00780; TAF-170; human, Homo sapiens. IN T00781; TAF-250; human, Homo sapiens. IN T00782; TAF-50; human, Homo sapiens. IN T00783; TAF-78; human, Homo sapiens. IN T00784; TAF-95; human, Homo sapiens. IN T00787; TAF-L; human, Homo sapiens. IN T00815; TFIIA; yeast, Saccharomyces cerevisiae. IN T00817; TFIIA; human, Homo sapiens. IN T00894; Vmw65; HSV-1, herpes simplex virus type 1. IN T00923; Zta; EBV, Epstein-Barr virus. IN T02068; PU.1; human, Homo sapiens. XX BS R02688; AD$E2AE1_21; Quality: 6; adenovirus type 5 BS R00367; AD$E4_21; Quality: 6; adenovirus type 5 BS R00998; AD$MLP_13; Quality: 6; adenovirus XX DR EMBL: X53415; SPTFIID(g). DR SwissProt: P17871; TF2D_SCHPO. DR PIR: A35873; A35873. DR PIR: S10940; S10940. DR PIR: S12112; S12112. XX RN [1] RA Fikes J. D., Becker D. M., Winston F., Guarente L. RT Striking conservation of TFIID in Schizosaccharomyces RT pombe and Saccharomyces cerevisiae RL Nature 346:291-294 (1990). RN [2] RA Gill G., Tjian R. RT A highly conserved domain of TFIID displays species specificity in vivo RL Cell 65:333-340 (1991). RN [3] RA Hoffmann A., Horikoshi M., Wang C. K., Schroeder St., RA Weil P. A., Roeder R. G. RT Cloning of the Schizosaccharomyces pombe TFIID gene RT reveals a strong conservation of functional domains RT present in Saccharomyces cerevisiae TFIID RL Genes Dev. 4:1141-1148 (1990). XX // AC T00796 XX ID T00796 XX DT 27.01.93 (created); hse. DT 16.05.97 (updated); hiwi. XX FA TBP XX SY TFIID; TFIIDtau; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL ; ; 4.5.1.0.1. XX SZ 316 AA; 34.7 kDa (cDNA), 35 kDa (SDS) XX SQ MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQ SQ QQQQQQQQQQAVATAAASVQQSTSQQPTQGASGQTPQLFHSQTLTTAPLPGTTPLYPSPM SQ TPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMR SQ IREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCD SQ VKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYE SQ AFENIYPILKGFRKTT XX SC SwissProt #P29037 XX CP ubiquitous XX FF is part of TFIID; FF binds as a monomer XX IN T00068; BRF1; yeast, Saccharomyces cerevisiae. IN T00169; c-Rel; mouse, Mus musculus. IN T00182; DBF4; human, Homo sapiens. IN T00197; Dr1; human, Homo sapiens. IN T00530; NC1; human, Homo sapiens. IN T00531; NC2; human, Homo sapiens. IN T00671; p53; human, Homo sapiens. IN T00702; PU.1; mouse, Mus musculus. IN T00759; Sp1; human, Homo sapiens. IN T00779; TAF-125; human, Homo sapiens. IN T00780; TAF-170; human, Homo sapiens. IN T00781; TAF-250; human, Homo sapiens. IN T00782; TAF-50; human, Homo sapiens. IN T00783; TAF-78; human, Homo sapiens. IN T00784; TAF-95; human, Homo sapiens. IN T00787; TAF-L; human, Homo sapiens. IN T00815; TFIIA; yeast, Saccharomyces cerevisiae. IN T00817; TFIIA; human, Homo sapiens. IN T00894; Vmw65; HSV-1, herpes simplex virus type 1. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00923; Zta; EBV, Epstein-Barr virus. IN T01806; p53; mouse, Mus musculus. IN T02068; PU.1; human, Homo sapiens. XX MX M00216; V$TATA_C MX M00252; V$TATA_01 XX BS R02247; TBP$CONS; Quality: 6 XX DR EMBL: D01034; MMTFIID(r). DR SwissProt: P29037; TF2D_MOUSE. DR PIR: S34437; S34437. XX RN [1] RA Sumita K., Makino Y., Katoh K., Kishimoto T., Muramatsu RA M., Mikoshiba K., Tamura T.-A. RT Structure of a mammalian TBP (TATA-binding protein) RT gene: isolation of the mouse TBP genome RL Nucleic Acids Res. 21:2769 (1993). RN [2] RA Wefald F. C., Devlin B. H., Williams S. RT Functional heterogeneity of mammalian TATA-box sequences RT revealed by interaction with a cell-specific enhancer RL Nature 344:260-262 (1990). RN [3] RA Maldonado E., Ha I., Cortes P., Weis L., Reinberg D. RT Factors involved in specific transcription by mammalian RT RNA polymerase II: role of transcription factors IIA, RT IID, and IIB during formation of a transcription-competent complex RL Mol. Cell. Biol. 10:6335-6347 (1990). RN [4] RA Tamura T., Sumita K., Fujino I., Aoyama A., Horikoshi RA M., Hoffmann A., Roeder R. G., Muramatsu M., Mikoshiba K. RT Striking homology of the 'variable' N-terminal as RT well as the 'conserved core' domains of the mouse RT and human TATA-factors (TFIID) RL Nucleic Acids Res. 19:3861-3865 (1991). RN [5] RA Greenblatt J. RT Roles of TFIID in transcriptional initiation by RNA polymerase II RL Cell 66:1067-1070 (1991). XX // AC T00797 XX ID T00797 XX DT 15.04.93 (created); ewi. DT 16.05.97 (updated); hiwi. XX FA TBP XX SY dTFIID; dTFIIDtau; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL ; ; 4.5.1.0.1. XX SZ 353 AA; 38.5 kDa (cDNA) XX SQ MDQMLSPNFSIPSIGTPLHQMEADQQIVANPVYHPPAVSQPDSLMPAPGSSSVQHQQQQQ SQ QSDASGGSGLFGHEPSLPLAHKQMQSYQPSASYQQQQQQQQLQSQAPGGGGSTPQSMMQP SQ QTPQSMMAHMMPMSERSVGGSGAGGGGDALSNIHQTMGPSTPMTPATPGSADPGIVPQLQ SQ NIVSTVNLCCKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKS SQ EDDSRLAARKYARIIQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHCNFSSYEPE SQ LFPGLIYRMVRPRIVLLIFVSGKVVLTGAKVRQEIYDAFDKIFPILKKFKKQS XX SC SwissProt #P20227 XX FT 31 52 serine-/proline-rich region FT 54 61 glutamine-rich region I (7/8) FT 62 92 serine-/proline-rich region FT 83 105 glutamine-rich region II (13/23) FT 104 125 serine-/threonine-/proline-rich region FT 151 173 serine-/threonine-/proline-rich region FT 173 353 conserved core FT 180 239 direct repeat I FT 270 330 direct repeat II XX SF glutamine-rich region (2x), glycine-rich region, serine-rich region XX CP ubiquitous XX IN T00068; BRF1; yeast, Saccharomyces cerevisiae. IN T00182; DBF4; human, Homo sapiens. IN T00197; Dr1; human, Homo sapiens. IN T00530; NC1; human, Homo sapiens. IN T00531; NC2; human, Homo sapiens. IN T00702; PU.1; mouse, Mus musculus. IN T00759; Sp1; human, Homo sapiens. IN T00779; TAF-125; human, Homo sapiens. IN T00780; TAF-170; human, Homo sapiens. IN T00781; TAF-250; human, Homo sapiens. IN T00782; TAF-50; human, Homo sapiens. IN T00783; TAF-78; human, Homo sapiens. IN T00784; TAF-95; human, Homo sapiens. IN T00787; TAF-L; human, Homo sapiens. IN T00815; TFIIA; yeast, Saccharomyces cerevisiae. IN T00817; TFIIA; human, Homo sapiens. IN T00894; Vmw65; HSV-1, herpes simplex virus type 1. IN T00923; Zta; EBV, Epstein-Barr virus. IN T02068; PU.1; human, Homo sapiens. XX MX M00252; V$TATA_01 XX BS R01001; AD$MLP_16; Quality: 6; adenovirus BS R00061; DROME$ADH_09; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: M38388; DMTATABF(r). DR EMBL: M38082; DMTFIID(r). DR SwissProt: P20227; TF2D_DROME. DR PIR: A35615; A35615. DR PIR: A38416; A38416. DR Flybase: FBgn0003687; Tbp. XX RN [1] RA Wang Y., Stumph W. E. RT RNA polymerase II/III transcription specificity determined RT by TATA box orientation RL Proc. Natl. Acad. Sci. USA 92:8606-8610 (1995). RN [2] RA Weinzierl R. O. J., Ruppert S., Dynlacht B. D., Tanese N., Tjian R. RT Cloning and expression of Drosophila TAFII60 and human RT TAFII70 reveal conserved interactions with other subunits of TFIID RL EMBO J. 12:5303-5309 (1993). RN [3] RA Muhich M. L., Iida C. T., Horikoshi M., Roeder R. G., Parker C. S. RT cDNA clone encoding Drosophila transcription factor TFIID RL Proc. Natl. Acad. Sci. USA 87:9148-9152 (1990). RN [4] RA Chen J.-L., Attardi L. D., Verrijzer C. P., Yokomori K., Tjian R. RT Assembly of recombinant TFIID reveals differential RT coactivator requirements for distinct transcriptional coactivators RL Cell 79:93-105 (1994). RN [5] RA Kokubo T., Yamashita S., Horikoshi M., Roeder R. G., Nakatani Y. RT Interaction between the N-terminal domain of the 230-kDa RT subunit and the TATA box-binding subunit of TFIID RT negatively regulates TATA-box binding RL Proc. Natl. Acad. Sci. USA 91:3520-3524 (1994). RN [6] RA Weinzierl R. O. J., Dynlacht B. D., Tjian R. RT Largest subunit of Drosophila transcription factor RT IID directs assembly of a complex containing TBP and a coactivator RL Nature 362:511-517 (1993). RN [7] RA Kokubo T., Takada R., Yamashita S., Gong D.-W., Roeder RA R. G., Horikoshi M., Nakatani Y. RT Identification of TFIID components required for transcriptional RT activation by upstream stimulatory factor RL J. Biol. Chem. 268:17554-17558 (1993). RN [8] RA Kokubo T., Gong D.-W., Wootton J. C., Horikoshi M., RA Roeder R. G., Nakatani Y. RT Molecular cloning of Drosophila TFIID subunits RL Nature 367:484-487 (1994). RN [9] RA Verrijzer C. P., Yokomori K., Chen J.-L., Tjian R. RT Drosophila TAFII150: similarity to yeast gene TSM-1 RT and specific binding to core promoter DNA RL Science 264:933-941 (1993). RN [10] RA Hoey T., Dynlacht B. D., Peterson M. G., Pugh B. F., Tjian R. RT Isolation and characterization of the Drosophila gene RT encoding the TATA box binding protein, TFIID RL Cell 61:1179-1186 (1990). RN [11] RA Safer B., Reinberg D., Jacob W. F., Maldonado E., RA Carcamo J., Garfinkel S., Cohen R. RT Interaction of CAP sequence site binding factor and RT transcription factor IID preceding and following binding RT to the adenovirus 2 major late promoter RL J. Biol. Chem. 266:10989-10994 (1991). XX // AC T00798 XX ID T00798 XX DT 15.10.92 (created); ewi. DT 05.06.97 (updated); hiwi. XX FA TBP XX SY SPT15; TFIID; TFIIDtau; yBTF1; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX CL ; ; 4.5.1.0.1. XX SZ 240 AA; 26.9 kDa (gene), 23-27 kDa/2.5S, 27 kDa (SDS) XX SQ MADEERLKEFKEANKIVFDPNTRQVWENQNRDGTKPATTFQSEEDIKRAAPESEKDTSAT SQ SGIVPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGK SQ MVVTGAKSEDDSKLASRKYARIIQKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHG SQ TFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPVLSEFRKM XX SC SwissProt #P13393 plus initiator methionine XX FT 1 57 non-conserved N-terminus, alters FT shape (enhances bending) and stability of TBP-DNA complex FT 60 240 DNA-binding and trans-activating domain (bipartite) [41]; FT 171 211 sigma 2.4-homology [46]; FT 68 127 direct repeat I FT 158 218 direct repeat II XX SF pI 9.4 (predicted) SF mutants: I143N inactive SF P65S active only with pol I SF T112K largely reduced activity with pol II SF K133,138L and K133,145L: no interaction with TFIIA SF E188N inactive with pol II only SF E188Y and P: active only in pol III system, more efficient SF in 5S transcirption than for tRNA synthesis SF F190Q: active for pol III only XX FF activator of all three polymerases; FF binds into the minor groove and bends DNA; FF binds VP16 with KD = 200 nM; FF pol III activation through the TFIIIB complex TBP-BRF+B''; FF helps HSF to bind to nucleosome-assembled DNA XX IN T00055; B''; yeast, Saccharomyces cerevisiae. IN T00068; BRF1; yeast, Saccharomyces cerevisiae. IN T00182; DBF4; human, Homo sapiens. IN T00197; Dr1; human, Homo sapiens. IN T00530; NC1; human, Homo sapiens. IN T00531; NC2; human, Homo sapiens. IN T00702; PU.1; mouse, Mus musculus. IN T00759; Sp1; human, Homo sapiens. IN T00779; TAF-125; human, Homo sapiens. IN T00780; TAF-170; human, Homo sapiens. IN T00781; TAF-250; human, Homo sapiens. IN T00782; TAF-50; human, Homo sapiens. IN T00783; TAF-78; human, Homo sapiens. IN T00784; TAF-95; human, Homo sapiens. IN T00787; TAF-L; human, Homo sapiens. IN T00815; TFIIA; yeast, Saccharomyces cerevisiae. IN T00816; TFIIA; wheat, Triticum aestivum. IN T00817; TFIIA; human, Homo sapiens. IN T00894; Vmw65; HSV-1, herpes simplex virus type 1. IN T00923; Zta; EBV, Epstein-Barr virus. IN T02068; PU.1; human, Homo sapiens. XX BS R01764; AD$E1B_02; Quality: 6; adenovirus BS R01732; AD$E1B_04; Quality: 6; adenovirus BS R00367; AD$E4_21; Quality: 6; adenovirus type 5 BS R03165; AD$IVA2_03; Quality: 6; adenovirus BS R01001; AD$MLP_16; Quality: 6; adenovirus BS R01015; AD$MLP_30; Quality: 6; adenovirus BS R01016; AD$MLP_31; Quality: 6; adenovirus BS R03156; AD$MLP_39; Quality: 6; adenovirus BS R03331; AS$HSF_03; Quality: 6 BS R03747; AS$TBP_01; Quality: 6 BS R03840; AS$TBP_02; Quality: 2 BS R03841; AS$TBP_03; Quality: 2 BS R03842; AS$TBP_04; Quality: 2 BS R03843; AS$TBP_05; Quality: 2 BS R03844; AS$TBP_06; Quality: 2 BS R00047; DROME$AC5C_01; Quality: 6; fruit fly, Drosophila melanogaster BS R03080; DROME$PEL_01; Quality: 6; fruit fly, Drosophila melanogaster BS R00705; HIV1$HIV1_12; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R03167; HS$GFAP_02; Quality: 6; human, Homo sapiens BS R03173; MOUSE$MT1_04; Quality: 6; mouse, Mus musculus BS R03809; Y$ARS1_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R03810; Y$ARS307_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R03811; Y$ARS307_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R03814; Y$ARSH4_01; Quality: 2; yeast, Saccharomyces cerevisiae BS R03815; Y$ARSH4_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R03172; Y$CUP1_07; Quality: 2; yeast, Saccharomyces cerevisiae BS R03161; Y$CYC1_13; Quality: 2; yeast, Saccharomyces cerevisiae BS R03162; Y$CYC1_14; Quality: 2; yeast, Saccharomyces cerevisiae BS R03164; Y$CYC1_15; Quality: 2; yeast, Saccharomyces cerevisiae BS R03812; Y$HMR_03; Quality: 2; yeast, Saccharomyces cerevisiae BS R03813; Y$HMR_04; Quality: 2; yeast, Saccharomyces cerevisiae BS R00970; Y$LEU2_02; Quality: 2; yeast, Saccharomyces cerevisiae BS R03163; Y$LEU2_03; Quality: 2; yeast, Saccharomyces cerevisiae XX DR EMBL: M29459; SCBTF1Y(g). DR EMBL: M26403; SCTFII01(g). DR EMBL: X16860; SCTFIID(g). DR EMBL: M27135; SCTFIIDA(g). DR SwissProt: P13393; TF2D_YEAST. DR PIR: A30366; A30366. DR PDB: 1ytf; YEAST TFIIA/TBP/DNA COMPLEX. XX RN [1] RA Hahn S., Buratowski S., Sharp P. A., Guarente L. RT Isolation of the gene encoding the yeast TATA binding RT protein TFIID: A gene identical to the SPT15 suppressor RT of Ty element insertions RL Cell 58:1173-1181 (1989). RN [2] RA Kuddus R., Schmidt M. C. RT Effect of the non-conserved N-terminus on the DNA RT binding activity of the yeast TATA binding protein RL Nucleic Acids Res. 21:1789-1796 (1993). RN [3] RA Poon D., Knittle R. A., Sabelko K. A., Yamamoto T., RA Horikoshi M., Roeder R. G., Weil P. A. RT Genetic and biochemical analyses of yeast TATA-binding protein mutants RL J. Biol. Chem. 268:5005-5013 (1993). RN [4] RA Schmidt M. C., Kao C. C., Pei R., Berk A. J. RT Yeast TATA-box transcription factor gene RL Proc. Natl. Acad. Sci. USA 86:7785-7789 (1989). RN [5] RA Schmidt M. C., Zhou Q., Berk A. J. RT Sp1 Activates Transcription without Enhancing DNA-Binding RT Activity of the TATA Box Factor RL Mol. Cell. Biol. 9:3299-3307 (1989). RN [6] RA Klein C., Struhl K. RT Increased recruitment of TATA-binding protein to the RT promoter by transcriptional activation domains in vivo RL Science 266:280-282 (1994). RN [7] RA Rudloff U., Strunnenberg H. G., Keaveney M., Grummt I. RT Yeast TBP can replace its human homologue in the RNA RT polymerase I-specific multisubunit factor SL1 RL J. Mol. Biol. 243:840-845 (1994). RN [8] RA Poon D., Bai Y., Campbell A. M., Bjorklund S., Kim RA Y.-J., Zhou S., Kornberg R. D., Weil P. A. RT Identification and characterization of a TFIID-like RT multiprotein complex from Saccharomyces cerevisiae RL Proc. Natl. Acad. Sci. USA 92:8224-8228 (1995). RN [9] RA Chatterjee S., Struhl K. RT Connecting a promoter-bound protein to TBP bypasses RT the need for a transcriptional activation domain RL Nature 374:820-822 (1995). RN [10] RA Klages N., Strubin M. RT Stimulation of RNA polymerase II transcription initiation RT by recruitment of TBP in vivo RL Nature 374:822-823 (1995). RN [11] RA Starr D. B., Hoopes B. C., Hawley D. K. RT DNA bending is an important component of site-specific RT recognition by the TATA binding protein RL J. Mol. Biol. 250:434-446 (1995). RN [12] RA Stargell L. A., Struhl K. RT The TBP-TFII interaction in the response to acidic activators in vivo RL Science 269:75-78 (1995). RN [13] RA Tan S., Hunziker Y., Sargent D. F., Richmond T. J. RT Crystal structure of a yeast TFIIA/TBP/DNA complex RL Nature 381:127-134 (1996). RN [14] RA Kim T. K., Zhao Y., Ge H., Bernstein R., Roeder R. G. RT TATA-binding protein residues implicated in a functional RT interplay between negative cofactor NC2(Dr1) and general RT factors TFIIA and TFIIB RL J. Biol. Chem. 270:10976-10981 (1995). RN [15] RA Nash H. A., Granston A. E. RT Similarity between the DNA-binding domains of IHF protein and TFIID protein RL Cell 67:1037-1038 (1991). RN [16] RA Kelleher III R. J., Flanagan P. M., Chasman D. I., RA Ponticelli A. S., Struhl K., Kornberg R. D. RT Yeast and human TFIIDs are interchangeable for the RT response to acidic transcriptional activators in vitro RL Genes Dev. 6:296-303 (1992). RN [17] RA Tansey W. P., Ruppert S., Tjian R., Herr W. RT Multiple regions of TBP participate in the response RT to transcriptional activators in vivo RL Genes Dev. 8:2756-2769 (1994). RN [18] RA Cavallini B., Huet J., Plassat J. L., Sentenac A., Egly J. M., Chambon P. RT A yeast activity can substitute for the HeLa cell TATA box factor RL Nature 334:77-80 (1988). RN [19] RA Meisterernst M., Horikoshi M., Roeder R. G. RT Recombinant yeast TFIID, a general transcription factor, RT mediates activation by the gene-specific factor USF RT in a chromatin assembly assay RL Proc. Natl. Acad. Sci. USA 87:9153-9157 (1990). RN [20] RA Fikes J. D., Becker D. M., Winston F., Guarente L. RT Striking conservation of TFIID in Schizosaccharomyces RT pombe and Saccharomyces cerevisiae RL Nature 346:291-294 (1990). RN [21] RA Cormack B. P., Strubin M., Ponticelli A. S., Struhl K. RT Functional differences between yeast and human TFIID RT are localized to the highly conserved region RL Cell 65:341-348 (1991). RN [22] RA Gill G., Tjian R. RT A highly conserved domain of TFIID displays species specificity in vivo RL Cell 65:333-340 (1991). RN [23] RA Yamamoto T., Horikoshi M., Wang J., Hasegawa S., Weil P. A., Roeder R. G. RT A bipartite DNA binding domain composed of direct RT repeats in the TATA box binding factor TFIID RL Proc. Natl. Acad. Sci. USA 89:2844-2848 (1992). RN [24] RA Lee D. K., Dejong J., Hashimoto S., Horikoshi M., Roeder R. G. RT TFIIA induces conformational changes in TFIID via RT interactions with the basic repeat RL Mol. Cell. Biol. 12:5189-5196 (1992). RN [25] RA Strubin M., Struhl K. RT Yeast and human TFIID with altered DNA-binding specificity for TATA elements RL Cell 68:721-730 (1992). RN [26] RA Auble D. T., Hahn S. RT An ATP-dependent inhibitor of TBP binding to DNA RL Genes Dev. 7:844-856 (1993). RN [27] RA Cormack B. P., Strubin M., Stargell L. A., Struhl K. RT Conserved and nonconserved functions of the yeast RT and human TATA-binding proteins RL Genes Dev. 8:1335-1343 (1994). RN [28] RA Griffith J. D., Makhov A., Zawel L., Reinberg D. RT Visualization of TBP oligomers binding and bending RT the HIV-1 and Adeno promoters RL J. Mol. Biol. 246:576-584 (1995). RN [29] RA Kim T. K., Hashimoto S., Kelleher III R. J., Flanagan RA P. M., Kornberg R. D., Horikoshi M., Roeder R. G. RT Effects of activation-defective TBP mutations on transcription RT initiation in yeast RL Nature 369:252-255 (1994). RN [30] RA Hahn S., Buratowski S., Sharp P. A., Guarente L. RT Identification of a yeast protein homologous in function RT to the mammalian general transcription factor, TFIIA RL EMBO J. 8:3379-3382 (1989). RN [31] RA Kaufman P. D., Rio D. C. RT Drosophila P-element transposase is a transcriptional repressor in vitro RL Proc. Natl. Acad. Sci. USA 88:2613-2317 (1991). RN [32] RA Truant R., Xiao H., Ingles C. J., Greenblatt J. RT Direct interaction between the transcriptional activation RT domain of human p53 and the TATA box-binding protein RL J. Biol. Chem. 268:2284-2287 (1993). RN [33] RA Cormack B. P., Struhl K. RT The TATA-binding protein is required for transcription RT by all three nuclear RNA polymerases in yeast cells RL Cell 69:685-696 (1992). RN [34] RA Schultz M. C., Reeder R. H., Hahn S. RT Variants of the TATA-binding protein can distinguish RT subsets of RNA polymerase I, II, and III promoters RL Cell 69:697-702 (1992). RN [35] RA Buratowski S., Zhou H. RT Transcription factor IID mutants defective for interaction RT with transcription factor IIA RL Science 255:1130-1132 (1992). RN [36] RA Kassavetis G. A., Joazeiro C. A. P., Pisano M., Geiduschek RA E. P., Colbert T., Hahn S., Blanco J. A. RT The role of the TATA-binding protein in the assembly RT and function of the multisubunit yeast RNA polymerase RT III transcription factor, TFIIIB RL Cell 71:1055-1064 (1992). RN [37] RA Buratowski S., Hahn S., Sharp P. A., Guarente L. RT Function of a yeast TATA element-binding protein in RT a mammalian transcription system RL Nature 334:37-42 (1988). RN [38] RA Eisenmann D. M., Dollard C., Winston F. RT SPT15, the gene encoding the yeast TATA binding factor RT TFIID, is required for normal transcription initiation in vivo RL Cell 58:1183-1191 (1989). RN [39] RA Horikoshi M., Wang C. K., Fuji H., Cromlish J. A., Weil P. A., Roeder R. G. RT Purification of a yeast TATA box-binding protein that RT exhibits human transcription factor IID activity RL Proc. Natl. Acad. Sci. USA 86:4843-4847 (1989). RN [40] RA Hahn S., Buratowski S., Sharp P. A., Guarente L. RT Yeast TATA-binding protein TFIID binds to TATA elements RT with both consensus and nonconsensus DNA sequences RL Proc. Natl. Acad. Sci. USA 86:5718-5722 (1989). RN [41] RA Horikoshi M., Yamamoto T., Ohkuma Y., Weil P. A., Roeder R. G. RT Analysis of structure-function relationships of yeast RT TATA box binding factor TFIID RL Cell 61:1171-1178 (1990). RN [42] RA Carcamo J., Maldonado E., Cortes P., Ahn M.-H., Ha I., Flint J., Reinberg D. RT A TATA-like sequence located downstream of the transcription RT initiation site is required for expression of an RNA RT polymerase II transcribed gene RL Genes Dev. 4:1611-1622 (1990). RN [43] RA Nakatani Y., Horikoshi M., Brenner M., Yamamoto T., RA Besnard F., Roeder R. G., Freese E. RT A downstream initiation element required for efficient RT TATA box binding and in vitro function of TFIID RL Nature 348:86-88 (1990). RN [44] RA Lee D. K., Horikoshi M., Roeder R. G. RT Interaction of TFIID in the minor groove of the TATA element RL Cell 67:1241-1250 (1991). RN [45] RA Reddy P., Hahn S. RT Dominant negative mutations in yeast TFIID define RT a bipartite DNA-binding region RL Cell 65:349-357 (1991). RN [46] RA Horikoshi M., Wang C. K., Fuji H., Cromlish J. A., Weil P. A., Roeder R. G. RT Cloning and structure of a yeast gene encoding a general RT transcription initiation factor TFIID that binds to the TATA box RL Nature 341:299-303 (1989). RN [47] RA Meisterernst M., Roeder R. G. RT Family of proteins that interact with TFIID and regulate promoter activity RL Cell 67:557-567 (1991). RN [48] RA Kambadur R., Culotta V., Hamer D. RT Cloned yeast and mammalian transcription factor TFIID RT gene products support basal but not activated metallothionein RT gene transcription RL Proc. Natl. Acad. Sci. USA 87:9168-9142 (1990). RN [49] RA Ingles C. J., Shales M., Cress W. D., Triezenberg S. J., Greenblatt J. RT Reduced binding of TFIID to transcriptionally compromised mutants of VP16 RL Nature 351:588-590 (1991). RN [50] RA Stringer K. F., Ingles C. J., Greenblatt J. RT Direct and selective binding of an acidic transcriptional RT activation domain to the TATA-box factor TFIID RL Nature 345:783-786 (1990). RN [51] RA Horikoshi M., Bertuccioli C., Takada R., Wang C. K., RA Yamamoto T., Roeder R. G. RT Transcription factor TFIID induces DNA bending upon RT binding to the TATA element RL Proc. Natl. Acad. Sci. USA 89:1060-1064 (1992). RN [52] RA Taylor I. C. A., Workman J. L., Schuetz T. J., Kingston R. E. RT Facilitated binding of GAL4 and heat shock factor RT to nucleosomal templates: differential function of DNA-binding domains RL Genes Dev. 5:1285-1298 (1991). RN [53] RA Buratowski S., Hahn S., Guarente L., Sharp P. A. RT Five Intermediate Complexes in Transcription Initiation by RNA Polymerase II RL Cell 56:549-561 (1989). XX // AC T00799 XX ID T00799 XX DT 15.04.93 (created); ewi. DT 16.05.97 (updated); hiwi. XX FA TBP-1 XX SY TFIID-1; XX OS mouse-ear cress, Arabidopsis thaliana OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC dilleniidae; capparales; brassicaceae XX CL ; ; 4.5.1.0.1. XX SZ 200 AA; 22.4 kDa (cDNA), 24 kDa (SDS) XX SQ MTDQGLEGSNPVDLSKHPSGIVPTLQNIVSTVNLDCKLDLKAIALQARNAEYNPKRFAAV SQ IMRIREPKTTALIFASGKMVCTGAKSEDFSKMAARKYARIVQKLGFPAKFKDFKIQNIVG SQ SCDVKFPIRLEGLAYSHAAFSSYEPELFPGLIYRMKVPKIVLLIFVSGKIVITGAKMRDE SQ TYKAFENIYPVLSEFRKIQQ XX SC SwissProt #P28147 XX FT 26 85 direct repeat I FT 116 176 direct repeat II FT 19 200 conserved core XX SF basic region SF sigma homology region XX CP ubiquitous XX BS R01001; AD$MLP_16; Quality: 6; adenovirus XX DR EMBL: X54996; ATTFIIDB(r). DR SwissProt: P28147; TF21_ARATH. DR PIR: S10946; S10946. XX RN [1] RA Hoffmann A., Sinn E., Yamamoto T., Wang J., Roy A., RA Horikoshi M., Roeder R. G. RT Highly conserved core domain and unique N terminus RT with presumptive regulatory motifs in a human TATA factor (TFIID) RL Nature 346:387-390 (1990). RN [2] RA Gasch A., Hoffmann A., Horikoshi M., Roeder R. G., Chua N.-H. RT Arabidopsis thaliana contains two gene for TFIID RL Nature 346:390-394 (1990). XX // AC T00800 XX ID T00800 XX DT 15.04.93 (created); ewi. DT 16.05.97 (updated); hiwi. XX FA TBP-2 XX SY TFIID-2; XX OS mouse-ear cress, Arabidopsis thaliana OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC dilleniidae; capparales; brassicaceae XX CL ; ; 4.5.1.0.1. XX SZ 200 AA; 22.4 kDa (cDNA), 24 kDa (SDS) XX SQ MADQGTEGSQPVDLTKHPSGIVPTLQNIVSTVNLDCKLDLKAIALQARNAEYNPKRFAAV SQ IMRIREPKTTALIFASGKMVCTGAKSEHLSKLAARKYARIVQKLGFPAKFKDFKIQNIVG SQ SCDVKFPIRLEGLAYSHSAFSSYEPELFPGLIYRMKLPKIVLLIFVSGKIVITGAKMREE SQ TYTAFENIYPVLREFRKVQQ XX SC SwissProt #P28148 XX FT 26 85 direct repeat I FT 116 176 direct repeat II FT 19 200 conserved core FT 131 147 TFIIB contact region [1]; XX SF basic region SF sigma homology region XX CP ubiquitous XX DR EMBL: X54995; ATTFIIDA(r). DR SwissProt: P28148; TF22_ARATH. DR PIR: S10945; S10945. XX RN [1] RA Nikolov D. B., Chen H., Halay E. D., Usheva A. A., RA Hisatake K., Lee D. K., Roeder R. G., Burley S. K. RT Crystal structure of a TFIIB-TBP-TATA-element ternary complex RL Nature 377:119-128 (1995). RN [2] RA Lee S., Hahn S. RT Model for binding of transcription factor TFIIB to the TBP-DNA complex RL Nature 376:609-612 (1995). RN [3] RA Nikolov D. B., Burley S. K. RT 2.1 A resolution refined structure of a TATA box-binding protein (TBP) RL Nature struct. Biol. 1:621-637 (1994). RN [4] RA Nikolov D. B., Hu S. H., Lin J., Gasch A., Hoffmann RA A., Horikoshi M., Chua N. H., Roeder R. G., Burley S. K. RT Crystal structure of TFIID TATA-box binding protein RL Nature 360:40-46 (1992). RN [5] RA Kim J. L., Burley S. K. RT 1.9 A resolution refined structure of TBP recognizing RT the minor groove of TATAAAAG RL Nature struct. Biol. 1:638-653 (1994). RN [6] RA Kim J. L., Nikolov D. B., Burley S. K. RT Co-crystal structure of TBP recognizing the minor groove of a TATA element RL Nature 365:520-527 (1993). RN [7] RA Hoffmann A., Sinn E., Yamamoto T., Wang J., Roy A., RA Horikoshi M., Roeder R. G. RT Highly conserved core domain and unique N terminus RT with presumptive regulatory motifs in a human TATA factor (TFIID) RL Nature 346:387-390 (1990). RN [8] RA Gasch A., Hoffmann A., Horikoshi M., Roeder R. G., Chua N.-H. RT Arabidopsis thaliana contains two gene for TFIID RL Nature 346:390-394 (1990). XX // AC T00801 XX ID T00801 XX DT 26.10.92 (created); ewi. DT 10.12.94 (updated); hse; ewi. XX FA TCF XX SY p62; p62TCF; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO EBF, f-EBF XX CL C0016; ETS; . XX SZ 53-57 kDa, 62 kDa (SDS) XX CP (HeLa) XX FF cooperates with SRF, may also cooperate with yeast MCM1; FF phosphorylation by MAP kinase enhances ternary complex formation [1]; XX IN T00500; MCM1; yeast, Saccharomyces cerevisiae. IN T00764; SRF; human, Homo sapiens. XX BS R03605; AS$SRF_01; Quality: 6 BS R00460; HS$CFOS_03; Quality: 5; human, Homo sapiens BS R00466; HS$CFOS_09; Quality: 2; human, Homo sapiens XX RN [1] RA Gille H., Sharrocks A. D., Shaw P. E. RT Phosphorylation of transcription factor p62TCF by RT MAP kinase stimulates ternary complex formation at c-fos promoter RL Nature 358:414-417 (1992). RN [2] RA Herrera R. E., Shaw P. E., Nordheim A. RT Occupation of the c-fos serum response element in RT vivo by a multi-protein complex is unaltered by growth factor induction RL Nature 340:68-70 (1989). RN [3] RA Shaw P. E., Schroeter H., Nordheim A. RT The Ability of a Ternary Complex to Form Over the RT Serum Response Element Correlates with Serum Inducibility RT of the Human c-fos Promoter RL Cell 56:563-572 (1989). RN [4] RA Schroeter H., Mueller C. G. F., Meese K., Nordheim A. RT Synergism in ternary complex formation between the RT dimeric glycoprotein p67SRF, polypeptide p62TCF and RT the c-fos serum response element RL EMBO J. 9:1123-1130 (1990). RN [5] RA Van de Wetering M., Oosterwegel M., Dooijes D., Clevers H. RT Identification and cloning of TCF-1, a T lymphocyte-specific RT transcription factor containing a sequence-specific HMG box RL EMBO J. 10:123-132 (1991). RN [6] RA Waterman M. L., Jones K. RT Purification of TCF-1alpha, a T-cell-specific transcription RT factor that activates the T-cell receptor Calpha gene RT enhancer in a context-dependent manner RL New Biologist 2:621-636 (1990). RN [7] RA Waterman M. L., Fischer W. H., Jones K. A. RT A thymus-specific member of the HMG protein family RT regulates the human T-cell receptor Calpha enhancer RL Genes Dev. 5:656-669 (1991). RN [8] RA Travis A., Amsterdam A., Belanger C., Grosschedl R. RT LEF-1, a gene encoding a lymphoid-specific with protein, RT an HMG domain, regulates T-cell receptor alpha enhancer function RL Genes Dev. 5:880-894 (1991). RN [9] RA Hipskind R. A., Rao V. N., Mueller C. G. F., Reddy E. S. P., Nordheim A. RT Ets-related protein Elk-1 is homologous to the c-fos RT regulatory factor p62TCF RL Nature 354:531-534 (1991). XX // AC T00802 XX ID T00802 XX DT 15.03.93 (created); ewi. DT 29.11.96 (updated); ewi. XX FA TCF-1alpha XX SY LEF-1 (mouse); XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0015; HMG; 4.6.2.0.1.1. XX SZ 399 AA; 44.2 kDa (cDNA), 55 kDa (SDS) XX SQ MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE SQ SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM SQ NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS SQ KQGMSRHPPAPEIPTFYPLSPGGVGQITPPLGWQGQPVYPITGGFRQPYPSSLSVDTSMS SQ RFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIK SQ KPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHM SQ QLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI XX SC sequence taken from Ref. [f277] XX FT 14 52 acidic region (14/39) FT 82 273 proline-rich region (36/192) FT 80 135 trans-activation domain A FT 174 256 trans-activation domain B FT 297 364 HMG domain FT 1 33 repressing domain XX SF sequence-specific DNA-binding is mediated by the disordered SF N-terminal part of the L-shaped HMG domain and by its third alpha-helix [2]; XX CP T-cells XX FF potent activator when bound in the right context, FF e. g. with an adjacently binding TCF-2 [1]; XX BS R04278; HS$ADA_03; Quality: 6; human, Homo sapiens BS R03107; HS$TCRA_05; Quality: 1; human, Homo sapiens BS R03470; MOUSE$CD4_02; Quality: 1; mouse, Mus musculus BS R02248; TCF1$CONS; Quality: 2 XX RN [1] RA Carlsson P., Waterman M. L., Jones K. A. RT The hLEF/TCF-1alpha HMG protein contains a context-dependent RT transcriptional activation domain that induces the RT TCRalpha enhancer in T cells RL Genes Dev. 7:2418-2430 (1993). RN [2] RA Read C. M., Cary P. D., Preston N. S., Lnenicek-Allen M., Crane-Robinson C. RT The DNA sequence specificity of HMG boxes lies in RT the minor wing of the structure RL EMBO J. 13:5639-5646 (1994). RN [3] RA Waterman M. L., Fischer W. H., Jones K. A. RT A thymus-specific member of the HMG protein family RT regulates the human T-cell receptor Calpha enhancer RL Genes Dev. 5:656-669 (1991). XX // AC T00803 XX ID T00803 XX DT 27.01.93 (created); hse. XX FA TCF-2alpha XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 63 kDa (SDS) XX CP T cells XX FF member of the Ets family XX BS R02248; TCF1$CONS; Quality: 6 BS R02249; TCF2ALPHA$CONS; Quality: 6 XX RN [1] RA Waterman M. L., Fischer W. H., Jones K. A. RT A thymus-specific member of the HMG protein family RT regulates the human T-cell receptor Calpha enhancer RL Genes Dev. 5:656-669 (1991). XX // AC T00804 XX ID T00804 XX DT 15.10.92 (created); ewi. XX FA TC-IIB XX SY H2TF1; KBF1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX BS R02189; KBF1$CONS; Quality: 6 BS R01059; MOUSE$M1H2KB_07; Quality: 6; mouse, Mus musculus BS R01406; SV$SV40_38; Quality: 6; SV40, simian virus 40 XX // AC T00805 XX ID T00805 XX DT 03.11.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA Tsh XX SY Teashirt; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.0.1. XX SZ 993 AA; 106.2 kDa (cDNA) XX SQ MLHEALMLEIYRQALNAGALPTARPRSTESANSSERCPSHDSNSSEHGGGAGSGGVGHRL SQ DAAALSTGVMPGEGPTTLHSSFPAVPQSLPSQPPSMEAYLHMVAAAAQQYGFPLAAAAAA SQ GAGPRLPLPLANEAAAPFKLPPQASPTASSNNSEALDFRTNLYGRAESAEPPASEGEEEE SQ FDDGANNPLDLSVGTRKRGHESEPQLGHIQVKKMFKSDSPPANSVASPSASQLLPGVNPY SQ LAAVAAANIFRAGQFPDWNSKNDLVVDPLEKMSDIVKGGASGMGTKEKMHSSKATTPQAA SQ SQPPKSPVQPTPNQNSESGGGSGGGAAGSGAVTKARHNIWQSHWQNKGVASSVFRCVWCK SQ QSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHSSGSA SQ SNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGE SQ MTKHMQETQHYTNILSQEQSISIKSGNANANSDAKESHNSLSSEESRTLSAVLTCKVCDK SQ AFNSLGDLSNHMAKNNHYAEPLLQSAGARKRPAPKKREKSLPVRKLLEMKGGSGTTQEDH SQ SNEKTSVQGKPGLGPGGGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAKNKSPEL SQ VEQKNGGQQRLRASSVLSAIEQMFTTSFDTPPRHASLPASSPSNSSTKNTSPVASSILKR SQ LGIDETVDYNKPLIDTNDPYYQHYRYTSSERSGSECSAEARPRLDAPTPEKQQQGGGHDE SQ ESSKPAIKQEREAESKPVKMEIKSEFVDEPNEAEETSKMEAAVVNGSATNNNNNIVERSS SQ PKTPSSAASPQTRLLPPRSPAESQRSVTPKSPASSHKSYDGSSEGTKKFPSDSLNALSSM SQ FDSLGSSGAGANSRAKLAGRSCCWRIRISREPHRRGELLGGLATILREEGEDRLSPRAET SQ KRETESFALFSLFRAKRIFNIFWFVSALPSPRT XX SC SwissProt #P22265 XX SF 1+1+1 zinc finger motifs SF alanine-rich region XX FF regulator of ventral trunk development XX DR EMBL: M57496; DMTSH(r). DR SwissProt: P22265; TSH_DROME. DR PIR: A38437; A38437. DR Flybase: FBgn0003866; tsh. XX RN [1] RA Fasano L., Roeder L., Core N., Alexandre E., Vola C., Jacq B., Kerridge S. RT The gene teashirt is required for the development RT of Drosophila embryonic trunk segments and encodes RT a protein with widely spaced zinc finger motifs RL Cell 64:63-79 (1991). XX // AC T00806 XX ID T00806 XX DT 15.10.92 (created); ewi. DT 25.02.97 (updated); ewi. XX FA TEF-1 XX SY GT-IIC; Sph factor; TEF1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO AP-5 XX CL C0024; TEA; 3.6.1.0.1. XX SZ 426 AA; 47.9 kDa (cDNA), 53 kDa (SDS) [3]; XX SQ IEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIIL SQ SDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQ SQ HMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAY SQ PIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFV SQ HIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQD SQ DAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCE SQ YMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHI SQ YRLVKD XX SC SwissProt #P28347 XX FT 167 426 trans-activating region [10]; FT 2 45 serine-rich region, acidic region (21/44) FT 26 98 DNA-binding domain FT 30 97 TEA domain FT 55 121 basic region FT 143 204 proline-rich region (16/62) FT 306 328 serine-,threonine-, tyrosine-rich region (11/23) FT 402 419 putative metal-binding Cys/His motif XX SF translation start codon used in vivo is a AUU (Ile) codon [10]; SF the TEA domain comprises three putative alpha-helices SF [1], together with two additional regions required for DNA-binding [4]; SF in the SV40 enhancer, TEF-1 binds to two distinct SF elements (GT-IIC, Sph) in a cooperative manner [3]; SF the C-terminal trans-activation domain is composed SF of (at least) eight cooperating parts [4]; XX CP (HeLa) CN lymphoid cells XX FF activator; FF function depends on a highly limiting cofactor [10], [4]; FF interference with TEF-1 / TFIID interaction by a B-cell specific factor [6]; XX BS R02030; HS$HPL3_01; Quality: 6; human, Homo sapiens BS R01236; PA$PY_18; Quality: 6; Py, polyoma virus BS R03900; RAT$BMHC_02; Quality: 5; rat, Rattus norvegicus BS R01403; SV$SV40_35; Quality: 2; SV40, simian virus 40 BS R01414; SV$SV40_46; Quality: 6; SV40, simian virus 40 BS R01417; SV$SV40_49; Quality: 2; SV40, simian virus 40 BS R02250; TEF1$CONS; Quality: 6 XX DR EMBL: M63896; HSTEF1(g). DR SwissProt: P28347; TEF1_HUMAN. XX RN [1] RA Buerglin T. R. RT The TEA domain: a novel, highly conserved DNA-binding motif RL Cell 66:11-12 (1991). RN [2] RA Mercurio F., Karin M. RT Transcription factors AP-3 and AP-2 interact with RT the SV40 enhancer in a mutually exclusive manner RL EMBO J. 8:1455-1460 (1989). RN [3] RA Davidson I., Xiao J. H., Rosales R., Staub A., Chambon P. RT The HeLa cell protein TEF-1 binds specifically and RT cooperatively to two SV40 enhancer motifs of unrelated sequence RL Cell 54:931-942 (1988). RN [4] RA Hwang J.-J., Chambon P., Davidson I. RT Characterization of the transcription activation function RT and the DNA binding domain of transcriptional enhancer factor-1 RL EMBO J. 12:2337-2348 (1993). RN [5] RA Chen Z., Friedrich G. A., Soriano P. RT Transcriptional enhancer factor 1 disruption by a RT retroviral gene trap leads to heart defects and embryonic lethality in mice RL Genes Dev. 8:2293-2301 (1994). RN [6] RA Chaudhary S., Brou C., Valentin M.-E., Burton N., RA Tora L., Chambon P., Davidson I. RT A cell-specific factor represses stimulation of transcription RT in vitro by transcriptional enhancer factor 1 RL Mol. Cell. Biol. 14:5290-5299 (1994). RN [7] RA Blatt C., DePamphilis M. L. RT Striking homology between the mouse and human transcriptional RT enhancer factor-1 (TEF-1) RL Nucleic Acids Res. 21:747-748 (1993). RN [8] RA Stewart A. F., Larkin S. B., Farrance I. K., Mar J. RA H., Hall D. E., Ordahl C. P. RT Muscle-enriched TEF-1 isoforms bind M-CAT elements RT from muscle-specific promoters and differentially activate transcription RL J. Biol. Chem. 269:3147-3150 (1994). RN [9] RA Xiao J. H., Davidson I., Ferrandon D., Rosales R., RA Vigneron M., Macchi M., Ruffenach F., Chambon P. RT One cell-specific and three ubiquitous proteins bind RT in vitro to overlapping motifs in the domain B1 of the SV40 enhancer RL EMBO J. 6:3005-3013 (1987). RN [10] RA Xiao J. H., Davidson I., Matthes H., Garnier J.-M., Chambon P. RT Cloning, expression, and transcriptional properties RT of the human enhancer factor TEF-1 RL Cell 65:551-568 (1991). XX // AC T00807 XX ID T00807 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA TEF-2 XX SY TEF2; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO AP-3 (1) XX SZ 57 kDa XX CP (HeLa) XX BS R01411; SV$SV40_43; Quality: 6; SV40, simian virus 40 BS R02251; TEF2$CONS; Quality: 6 XX RN [1] RA Mercurio F., Karin M. RT Transcription factors AP-3 and AP-2 interact with RT the SV40 enhancer in a mutually exclusive manner RL EMBO J. 8:1455-1460 (1989). RN [2] RA Davidson I., Xiao J. H., Rosales R., Staub A., Chambon P. RT The HeLa cell protein TEF-1 binds specifically and RT cooperatively to two SV40 enhancer motifs of unrelated sequence RL Cell 54:931-942 (1988). XX // AC T00808 XX ID T00808 XX DT 12.03.93 (created); ewi. XX FA TEF 1 XX SY TEF1; XX OS mouse-ear cress, Arabidopsis thaliana OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC dilleniidae; capparales; brassicaceae XX BS R03062; AT$EF1A1_01; Quality: 6; mouse-ear cress, Arabidopsis thaliana BS R03063; AT$EF1A4_01; Quality: 6; mouse-ear cress, Arabidopsis thaliana XX RN [1] RA Curie C., Liboz T., Bardet C., Gander E., Medale C., Axelos M., Lescure B. RT Cis and trans-acting elements involved in the activation RT of Arabidopsis thaliana A1 gene encoding the translation RT elongation factor EF-1alpha RL Nucleic Acids Res. 19:1305-1310 (1991). XX // AC T00809 XX ID T00809 XX DT 14.12.92 (created); ewi. DT 28.09.93 (updated); ewi. XX FA TF68 XX SY ECRE-3; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (F9, undifferentiated cells only) XX FF different from ATF/CREB XX BS R02686; AD$E2AE1_19; Quality: 6; adenovirus type 5 BS R03467; AD$E2AE1_22; Quality: 6; adenovirus type 5 BS R03001; MOUSE$SURF2_01; Quality: 6; mouse, Mus musculus BS R01794; MOUSE$TCRB_11; Quality: 6; mouse, Mus musculus XX RN [1] RA Murray E. J., Stott D., Rigby P. W. J. RT Sequences and factors required for the F9 embryonal RT carcinoma stem cell E1a-like activity RL Mol. Cell. Biol. 11:5534-5540 (1991). RN [2] RA Yu-Lee L.-Y., Hrachovy J. A., Stevens A. M., Schwarz L. A. RT Interferon-Regulatory Factor 1 Is an Immediate-Early RT Gene under Transcriptional Regulation by Prolactin in Nb2 T Cells RL Mol. Cell. Biol. 10:3087-3094 (1990). XX // AC T00810 XX ID T00810 XX DT 27.01.93 (created); hse. DT 24.01.97 (updated); ewi. XX FA TFE3-L XX SY TFE3; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0012; bHLH-ZIP; 1.3.1.1.1.1. XX SZ 326 AA [4], >446 AA [1]; XX SQ TSGTRRREQAAAAPFPSPAPASPAISVIGVSAGGHTLSRPPPAQVPREVLKVQTHLENPT SQ RYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPSSAQPLPAPETAHATGPTGSAPNSP SQ MALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTAGLQLPSTLPVSGNLLDVYS SQ SQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIK SQ ELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRI SQ QELELQAQIHGLPVPPNPGLLSLTTSSVSDSLKPEQLDIEEEGRPSTTFHVSGGPAQNAP SQ PQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEGMVGGLSGGALSPLRAASD SQ PLLSSVSPAVSNASSRRSSFSIEEES XX SC translated from EMBL #S76673 XX FT 134 168 missing in splice variant TFE3-S [4]; FT 220 232 basic region FT 233 273 helix-loop-helix domain FT 282 303 leucine zipper (L4) XX SF the leucine zipper contributes to dimerization specificity [1], [2]; SF tetramers are formed free in solution [2]; SF TFE3 molecules remotely bound to enhancer/promoter SF elements which may thus interact XX FF TFE3-L is an approximately 3-fold stronger activator than TFE3-S [4]; FF cooperating with ITF-1, TFE3 can mediate lymphoid-specific FF activation through combined elements (such as muE5 FF and muE3 in the IgH enhancer) [3]; XX IN T00810; TFE3-L; mouse, Mus musculus. IN T00812; TFEB; human, Homo sapiens. IN T00814; TFE3-S; mouse, Mus musculus. XX BS R00853; MOUSE$IGH_19; Quality: 6; mouse, Mus musculus BS R02252; TFE3$CONS; Quality: 6 XX DR EMBL: S76673; S76673(r). XX RN [1] RA Roman C., Matera A. G., Cooper C., Artandi S., Blain RA S., Ward D. C., Calame K. RT mTFE3, an X-linked transcriptional activator containing RT basic helix-loop-helix and zipper domains, utilizes RT the zipper to stabilize both DNA binding and multimerization RL Mol. Cell. Biol. 12:817-827 (1992). RN [2] RA Artandi S. E., Cooper C., Shrivastava A., Calame K. RT The basic helix-loop-helix-zipper domain of TFE3 mediates RT enhancer-promoter interaction RL Mol. Cell. Biol. 14:7704-7716 (1994). RN [3] RA Ruezinsky D., Beckmann H., Kadesh T. RT Modulation of the Igh enhancer's cell type through a genetic switch RL Genes Dev. 5:29-37 (1991). RN [4] RA Roman C., Cohn L., Calame K. RT A dominant negative form of transcription activator RT mTFE3 created by differential splicing RL Science 254:94-97 (1991). XX // AC T00811 XX ID T00811 XX DT 20.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA TFE3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0012; bHLH-ZIP; 1.3.1.1.1.1. XX SZ >536 AA; >59 kDa (cDNA), 62-68 kDa (SDS) XX SQ EFGRASQALTPPPGKASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDE SQ IISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELP SQ NIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGT SQ ILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPGTPGL SQ LSLATTSTSDSLKPEQLDIEEEGRPGARTFHVGGGPAQNAPHQQPPAPPSDALLDLHFPS SQ DHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSLLSPRPAAAAA SQ ASAWKRSPDQASPLPWTFPPRKGGPCRMRPRLFPHPPMRLPRYLGRGDVIRPHPCNQARR SQ RSQMRPCTFPKGTAQCRYFRRRRLEKDMRSGPAPWGSQPHPCPCGTHPCPGEGRRQDEVS SQ TLSPRDCPSQVSWEREMSGCCSILCLGTTSLVRPGTEEESSNGGPSPGGLSSAPSP XX SC SwissProt #P19532 XX FT 41 126 transcription activating region, FT negatively charged, with potential amphipathic helix FT 140 152 basic region FT 153 193 helix-loop-helix domain FT 202 223 leucine zipper (L4) FT 366 536 proline-/arginine-rich region XX SF incompatible leucine zipper structures and HLH-ZIP SF distances prevent TFE3 dimerization with USF, ITF-1, or Id [3]; SF TFE3 induces DNA bending towards the minor groove by approx. 74-82 deg [1]; XX FF strong activator [2]; FF different from NF-muE3 or USF [2]; XX IN T00811; TFE3; human, Homo sapiens. IN T00812; TFEB; human, Homo sapiens. IN T01552; TFEC; rat, Rattus norvegicus. IN T01553; Mi; human, Homo sapiens. IN T01554; Mi; mouse, Mus musculus. XX BS R00992; AD$MLP_07; Quality: 6; adenovirus BS R04412; MOUSE$FCGR3A_01; Quality: 2; mouse, Mus musculus BS R00853; MOUSE$IGH_19; Quality: 2; mouse, Mus musculus BS R02252; TFE3$CONS; Quality: 6 XX DR EMBL: X51330; HSTFE3(r). DR SwissProt: P19532; TFE3_HUMAN. DR PIR: A34596; A34596. DR PIR: S10379; S10379. XX RN [1] RA Fisher D. E., Parent L. A., Sharp P. A. RT Myc/Max and other helix-loop-helix/leucine zipper RT proteins bend DNA toward the minor groove RL Proc. Natl. Acad. Sci. USA 89:11779-11783 (1992). RN [2] RA Beckmann H., Su L.-K., Kadesch T. RT TFE3: a helix-loop-helix protein that activates transcription RT through the immunoglobulin enhancer E3 motif RL Genes Dev. 4:167-179 (1990). RN [3] RA Beckmann H., Kadesch T. RT The leucine zipper of TFE3 dictates helix-loop-helix RT dimerization specificity RL Genes Dev. 5:1057-1066 (1991). XX // AC T00812 XX ID T00812 XX DT 20.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA TFEB XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0012; bHLH-ZIP; 1.3.1.1.2. XX SZ >514 AA; 60 kDa (cDNA) XX SQ EFRGGVTAGARAPARGSVTAEAAARAGRGSGRGADGGREGRTGRASLVARGRSRPGAGGG SQ HSLRARHPNLRQVAGAGARAADRLTFRAREPAPAATMASRIGLRMQLMREQAQQEEQRER SQ MQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHL SQ QQSQHQKVREYLSETYGNKFAAAHISPAQALRNPHQPPPQGCELDTCCPPPLATVLPISP SQ MAMLHIGSNPERELDDVIDNIMRLTMSLGYINPEMQMPNTLPLSSSHLNVYSSDPQVTAS SQ LVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIP SQ KANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQA SQ RVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPL SQ PTQPPSPFHHLDFSHSLSFGGREDEGPPGYPDRN XX SC SwissProt #P19484 XX FT 4 98 glycine-/alanine-rich region FT 106 140 glutamine-rich region FT 331 345 basic region FT 346 386 helix-loop-helix domain FT 395 416 leucine zipper (L4) FT 464 511 proline-rich region XX SF TFEB is closely related to TFE3 SF leucine zipper: essential for dimerization [5]; SF free in solution: tetramerization [5]; SF induces DNA bending towards the minor groove to 74-82 deg [1]; SF basic region becomes alpha-helically folded upon binding to DNA (CD) [2]; SF K334, H337, E340, R343: critical for DNA-binding [2]; SF C-terminal part of basic region: clamp, forming phosphate SF contacts across the major groove framing a base pair contact [2]; SF XX IN T00810; TFE3-L; mouse, Mus musculus. IN T00811; TFE3; human, Homo sapiens. IN T00812; TFEB; human, Homo sapiens. IN T00814; TFE3-S; mouse, Mus musculus. IN T01553; Mi; human, Homo sapiens. IN T01554; Mi; mouse, Mus musculus. XX BS R00992; AD$MLP_07; Quality: 6; adenovirus BS R02094; AS$MYC_02; Quality: 2 BS R03231; AS$TFEB_01; Quality: 6 BS R03232; AS$TFEB_02; Quality: 6 BS R03233; AS$TFEB_03; Quality: 6 BS R02253; TFEB$CONS; Quality: 6 XX DR EMBL: M33782; HSTFEB(r). DR SwissProt: P19484; TFEB_HUMAN. DR PIR: A35658; A35658. XX RN [1] RA Fisher D. E., Parent L. A., Sharp P. A. RT Myc/Max and other helix-loop-helix/leucine zipper RT proteins bend DNA toward the minor groove RL Proc. Natl. Acad. Sci. USA 89:11779-11783 (1992). RN [2] RA Fisher D. E., Parent L. A., Sharp P. A. RT High affinity DNA-binding Myc analogs: recognition by an alpha helix RL Cell 72:467-476 (1993). RN [3] RA Halazonetis T. D., Kandil A. N. RT Determination of the C-MYC DNA-binding site RL Proc. Natl. Acad. Sci. USA 88:6162-6166 (1991). RN [4] RA Carr C. S., Sharp Ph. A. RT A Helix-Loop-Helix Protein Related to the Immunoglobulin RT E Box-Binding Proteins RL Mol. Cell. Biol. 10:4384-4388 (1990). RN [5] RA Fisher D. E., Carr C. S., Parent L. A., Sharp P. A. RT TFEB has DNA-binding and oligomerization properties RT of a unique helix-loop-helix/leucine zipper family RL Genes Dev. 5:2342-2352 (1991). XX // AC T00814 XX ID T00814 XX DT 20.10.92 (created); ewi. DT 24.01.97 (updated); ewi. XX FA TFE3-S XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0012; bHLH-ZIP; 1.3.1.1.1.2. XX SZ >411 AA XX SQ TSGTRRREQAAAAPFPSPAPASPAISVIGVSAGGHTLSRPPPAQVPREVLKVQTHLENPT SQ RYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPSSAQPLPAPETAHATGPTGSAPNSP SQ MALLTIGSSSEKELPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALL SQ KERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKE SQ QQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPNPGLLSLTTSSVSDSLKPE SQ QLDIEEEGRPSTTFHVSGGPAQNAPPQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLED SQ ILMEEEGMVGGLSGGALSPLRAASDPLLSSVSPAVSNASSRRSSFSIEEES XX SC translated from EMBL #S76673 and edited XX FT 178 197 basic region FT 200 237 helix-loop-helix motif FT 247 268 leucine zipper (L4) XX FF trans-dominant negative regulator XX IN T00810; TFE3-L; mouse, Mus musculus. IN T00812; TFEB; human, Homo sapiens. IN T00814; TFE3-S; mouse, Mus musculus. XX BS R04253; MOUSE$ADH2_01; Quality: 4; mouse, Mus musculus BS R00844; MOUSE$IGH_10; Quality: 2; mouse, Mus musculus BS R00853; MOUSE$IGH_19; Quality: 2; mouse, Mus musculus BS R00240; MOUSE$MCK_01; Quality: 4; mouse, Mus musculus BS R02252; TFE3$CONS; Quality: 6 XX RN [1] RA Roman C., Matera A. G., Cooper C., Artandi S., Blain RA S., Ward D. C., Calame K. RT mTFE3, an X-linked transcriptional activator containing RT basic helix-loop-helix and zipper domains, utilizes RT the zipper to stabilize both DNA binding and multimerization RL Mol. Cell. Biol. 12:817-827 (1992). RN [2] RA Roman C., Cohn L., Calame K. RT A dominant negative form of transcription activator RT mTFE3 created by differential splicing RL Science 254:94-97 (1991). XX // AC T00815 XX ID T00815 XX DT 15.10.92 (created); ewi. DT 26.05.97 (updated); hiwi. XX FA TFIIA XX SY TOA1; TOA2; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 286 AA (TOA1), 122 AA (TOA2); 32.2 kDa (TOA1), 13.5 kDa (TOA2) SZ , 90kDa (GF), 32 kDa+13.5 kDa (SDS), 43+13 kDa (SDS) XX SQ MSNAEASRVYEIIVESVVNEVREDFENAGIDEQTLQDLKNIWQKKLTETKVTTFSWDNQF SQ NEGNINGVQNDLNFNLATPGVNSSEFNIKEENTGNEGLILPNINSNNNIPHSGETNINTN SQ TVEATNNSGATLNTNTSGNTNADVTSQPKIEVKPEIELTINNANITTVENIDDESEKKDD SQ EEKEEDVEKTRKEKEQIEQVKLQAKKEKRSALLDTDEVGSELDDSDDDYLISEGEEDGPD SQ ENLMLCLYDKVTRTKARWKCSLKDGVVTINRNDYTFQKAQVEAEWV XX SC SwissProt # P32773; TOA1 XX FT 1 54 required for subunit association and TBP-TATA-binding [7]; FT 169 188 acidic region (13/20) FT 217 286 required for TBP-TATA-binding [7]; FT 221 241 acidic region (12/21) FT 241 286 required for subunit association [7]; XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. IN T00820; TFIID; human, Homo sapiens. XX BS R01015; AD$MLP_30; Quality: 6; adenovirus BS R01016; AD$MLP_31; Quality: 6; adenovirus BS R00970; Y$LEU2_02; Quality: 6; yeast, Saccharomyces cerevisiae XX DR EMBL: M85248; SCTFIIAA(g). DR EMBL: M85249; SCTFIIAB(r). DR EMBL: X75781; SCXI286K(empty). DR EMBL: Z28058; SCYKL058W(g). DR SwissProt: P32773; TOA1_YEAST. DR SwissProt: P32774; TOA2_YEAST. DR PIR: A41810; A41810. DR PIR: B41810; B41810. DR PIR: S39189; S39189. DR PDB: 1ytf; YEAST TFIIA/TBP/DNA COMPLEX. XX RN [1] RA Stargell L. A., Struhl K. RT The TBP-TFII interaction in the response to acidic activators in vivo RL Science 269:75-78 (1995). RN [2] RA Tan S., Hunziker Y., Sargent D. F., Richmond T. J. RT Crystal structure of a yeast TFIIA/TBP/DNA complex RL Nature 381:127-134 (1996). RN [3] RA Ranish J. A., Lane W. S., Hahn S. RT Isolation of two genes that encode subunits of the RT yeast transcription factor IIA RL Science 255:1127-1129 (1992). RN [4] RA Ranish J. A., Hahn S. RT The yeast general transcription factor TFIIA is composed RT of two polypeptide subunits RL J. Biol. Chem. 266:19320-19327 (1991). RN [5] RA Rasmussen S. W. RT Sequence of a 28.6 kb Region of Yeast Chromosome XI RT Includes the FAB1 and TOA2 Genes, an Open Reading RT Frame (ORF) Similar to a Translationally Controlled RT Tumor Protein, one ORF Containing Motifs also Found RT in Plant Storage Proteins ... RL Yeast 10:63-68 (1994). RN [6] RA Imbalzano A. N., Zaret K. S., Kingston R. E. RT Transcription factor (TF) IIB and TFIIA can independently RT increase the affinity of the TATA-binding protein for DNA RL J. Biol. Chem. 269:8280-8286 (1994). RN [7] RA Kang J. J., Auble D. T., Ranish J. A., Hahn S. RT Analysis of the yeast transcription factor TFIIA: RT Distinct functional regions and a polymerase II-specific RT role in basal and activated transcription RL Mol. Cell. Biol. 15:1234-1243 (1995). RN [8] RA Hahn S., Buratowski S., Sharp P. A., Guarente L. RT Identification of a yeast protein homologous in function RT to the mammalian general transcription factor, TFIIA RL EMBO J. 8:3379-3382 (1989). RN [9] RA Schultz M. C., Reeder R. H., Hahn S. RT Variants of the TATA-binding protein can distinguish RT subsets of RNA polymerase I, II, and III promoters RL Cell 69:697-702 (1992). RN [10] RA Buratowski S., Hahn S., Guarente L., Sharp P. A. RT Five Intermediate Complexes in Transcription Initiation by RNA Polymerase II RL Cell 56:549-561 (1989). XX // AC T00816 XX ID T00816 XX DT 15.10.92 (created); ewi. XX FA TFIIA XX OS wheat, Triticum aestivum OC eukaryota; plantae; embryobionta; magnoliophyta; liliopsida; OC commelinidae; cyperales; poaceae XX SZ 35 kDa (SDS) XX CP germ XX IN T00798; TBP; yeast, Saccharomyces cerevisiae. IN T00820; TFIID; human, Homo sapiens. XX BS R01606; AD$MLP_35; Quality: 6; adenovirus type 2 XX RN [1] RA Yu X.-B., Burke C., Zhang J., Marchitelli L. J., Davis E. A., Ackermann S. RT Transcription factor IIA of wheat and human interacts RT similarly with the adenovirus-2 major late promoter RL Biochem. Biophys. Res. Commun. 168:498-505 (1990). RN [2] RA Burke C., Yu X.-B., Marchitelli L., Davis E. A., Ackermann S. RT Transcription factor IIA of wheat and human function RT similarly with plant and animal viral promoters RL Nucleic Acids Res. 18:3611-3620 (1990). XX // AC T00817 XX ID T00817 XX DT 15.10.92 (created); ewi. DT 26.05.97 (updated); hiwi. XX FA TFIIA XX SY DBF3; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 376 AA (alpha/beta precursor, major), 337 AA (alpha.minor), SZ 109 AA (gamma); 41.5 kDa (alpha/beta precursor), 160 kDa (GF), SZ 120-140 kDa, 38 kDa (alpha subunit), 20 kDa (beta), 13 kDa (gamma) SZ (SDS), 35+ XX SQ MANSANTNTVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFH SQ SEEQQLLLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIV SQ PDSKLIQHMNASNMSAAATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQ SQ SVVLQQQVIPQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTV SQ AAPTPAQAQITATGQQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKE SQ KDGAEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNL SQ NGRDYIFSKAIGDAEW XX SC SwissProt # P52655; alpha/beta precursor, major XX FT 1 39 missing in alternative translation start product [7]; FT 64 117 glutamine-rich region (24/54) FT 81 87 histidine-rich region (7/7) FT 282 332 acidic region (32/52) XX CP (HeLa) XX FF binds to and stabilizes TFIID/TBP-TATA box-complexes XX IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. IN T00820; TFIID; human, Homo sapiens. XX BS R03170; AD$IVA2_04; Quality: 6; adenovirus BS R00996; AD$MLP_11; Quality: 6; adenovirus BS R01002; AD$MLP_17; Quality: 6; adenovirus type 5 BS R01015; AD$MLP_30; Quality: 6; adenovirus BS R01016; AD$MLP_31; Quality: 6; adenovirus BS R01017; AD$MLP_32; Quality: 6; adenovirus BS R01018; AD$MLP_33; Quality: 6; adenovirus BS R01605; AD$MLP_34; Quality: 6; adenovirus type 2 BS R00705; HIV1$HIV1_12; Quality: 6; HIV-1, human immunodeficiency virus type 1 XX DR EMBL: U14193; HS14193(r). DR EMBL: X81713; HSHTFIIAS(r). DR EMBL: X75383; HSRNATFII(empty). DR SwissProt: P52655; T2AA_HUMAN. XX RN [1] RA Reinberg D., Horikoshi M., Roeder R. G. RT Factors involved in specific transcription by mammalian RT RNA polymerase II. Functional analysis of initiation RT factors IIA and IID and identification of a new factor RT operating at sequences downstream of the initiation site RL J. Biol. Chem. 262:3322-3330 (1987). RN [2] RA Yu X.-B., Burke C., Zhang J., Marchitelli L. J., Davis E. A., Ackermann S. RT Transcription factor IIA of wheat and human interacts RT similarly with the adenovirus-2 major late promoter RL Biochem. Biophys. Res. Commun. 168:498-505 (1990). RN [3] RA Lee D. K., Dejong J., Hashimoto S., Horikoshi M., Roeder R. G. RT TFIIA induces conformational changes in TFIID via RT interactions with the basic repeat RL Mol. Cell. Biol. 12:5189-5196 (1992). RN [4] RA Cortes P., Flores O., Reinberg D. RT Factors involved in specific transcription by mammalian RT RNA polymerase II: Purification and analysis of transcription RT factor IIA and identification of transcription factor IIJ RL Mol. Cell. Biol. 12:413-421 (1992). RN [5] RA Ozer J., Moore P. A., Bolden A. H., Lee A., Rosen C. A., Lieberman P. M. RT Molecular cloning of the small (gamma) subunit of RT human TFIIA reveals functions critical for activated transcription RL Genes Dev. 8:2324-2335 (1994). RN [6] RA Sun X., Ma D., Sheldon M., Yeung K., Reinberg D. RT Reconstitution of human TFIIA activity from recombinant RT polypeptides: a role in TFIID-mediated transcription RL Genes Dev. 8:2336-2348 (1994). RN [7] RA Ma D., Watanabe H., Mermelstein F., Admon A., Oguri RA K., Sun X., Wada T., Imai T., Shiroya T., Reinberg D., Handa H. RT Isolation of a cDNA encoding the largest subunit of RT TFIIA reveals functions important for activated transcription RL Genes Dev. 7:2246-2257 (1993). RN [8] RA Dejong J., Roeder R. G. RT A single cDNA hTFIIA/alpha encodes both the p35 and RT p19 subunits of human TFIIA RL Genes Dev. 7:2220-2234 (1993). RN [9] RA Usuda Y., Kubota A., Berk A. J., Handa H. RT Affinity purification of transcription factor IIA RT from HeLa cell nuclear extracts RL EMBO J. 10:2305-2310 (1991). RN [10] RA Bungert J., Waldschmidt R., Kober I., Seifart K. H. RT Transcription factor IIA is inactivated during terminal RT differentiation of avian erythroid cells RL Proc. Natl. Acad. Sci. USA 90:11678-11682 (1993). RN [11] RA Merino A., Madden K. R., Lane W. S., Champoux J. J., Reinberg D. RT DNA topoisomerase I is involved in both repression RT and activation of transcription RL Nature 365:227-232 (1993). RN [12] RA Dejong J., Bernstein R., Roeder R. G. RT Human general transcription factor TFIIA: Characterization RT of a cDNA encoding the small subunit and requirement RT for basal and activated transcription RL Proc. Natl. Acad. Sci. USA 92:3313-3317 (1995). RN [13] RA Ma D., Olave I., Merino A., Reinberg D. RT Separation of the transcriptional coactivator and RT antirepression functions of transcription factor IIA RL Proc. Natl. Acad. Sci. USA 93:6583-6588 (1996). RN [14] RA Meisterernst M., Roeder R. G. RT Family of proteins that interact with TFIID and regulate promoter activity RL Cell 67:557-567 (1991). XX // AC T00818 XX ID T00818 XX DT 20.11.92 (created); ewi. DT 26.05.97 (updated); hiwi. XX FA TFIIB XX SY CB; CI; FA; factor E; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 316 AA; 34.8 kDa (cDNA), 33, 35 kDa (SDS) XX SQ MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKA SQ TKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKE SQ ITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEI SQ CAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAV SQ ELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLF SQ PTDFKFDTPVDKLPQL XX SC SwissProt #Q00403 XX FT 11 64 required for basal transcription [19]; FT 15 37 putative zinc finger (Cys-X2-His-X15-Cys-X2-Cys) FT 106 305 binding to TBP-TATA complexes [19], [22], [6]; FT 124 200 direct repeat 1 FT 165 208 binding to TBP [2]; FT 178 201 binding to T3R [10]; FT 190 210 homology to sigma70 (sigma2.1/sigma2.2) [12], [13]; FT 218 294 direct repeat 2 XX FF binding to (TATA-DNA)+TFIID(+TFIIA); FF anchors pol II? XX IN T00176; CTF-1; human, Homo sapiens. IN T00794; TBP; human, Homo sapiens. XX BS R03170; AD$IVA2_04; Quality: 6; adenovirus BS R00996; AD$MLP_11; Quality: 6; adenovirus BS R01002; AD$MLP_17; Quality: 6; adenovirus type 5 BS R01016; AD$MLP_31; Quality: 6; adenovirus BS R01017; AD$MLP_32; Quality: 6; adenovirus BS R01018; AD$MLP_33; Quality: 6; adenovirus BS R00705; HIV1$HIV1_12; Quality: 6; HIV-1, human immunodeficiency virus type 1 XX DR EMBL: X59268; HSTF2B(r). DR EMBL: M76766; HSTFIIB(r). DR SwissProt: Q00403; TF2B_HUMAN. DR PIR: S17654; S17654. XX RN [1] RA Kwok R. P., Lundblad J. R., Chrivia J. C., Richards RA J. P., Baechinger H. P., Brennan R. G., Roberts S. RA G., Green M. R., Goodman R. H. RT Nuclear protein CBP is a coactivator for the transcription factor CREB RL Nature 370:223-226 (1994). RN [2] RA Nikolov D. B., Chen H., Halay E. D., Usheva A. A., RA Hisatake K., Lee D. K., Roeder R. G., Burley S. K. RT Crystal structure of a TFIIB-TBP-TATA-element ternary complex RL Nature 377:119-128 (1995). RN [3] RA Lee S., Hahn S. RT Model for binding of transcription factor TFIIB to the TBP-DNA complex RL Nature 376:609-612 (1995). RN [4] RA Klemm R. D., Goodrich J. A., Zhou S., Tjian R. RT Molecular cloning and expression of the 32-kDa subunit RT of human TFIID reveals interactions with VP16 and RT TFIIB that mediate transcriptional activation RL Proc. Natl. Acad. Sci. USA 92:5788-5792 (1995). RN [5] RA Goodrich J. A., Hoey T., Thut C. J., Admon A., Tjian R. RT Drosophila TAFII40 interacts with both a VP16 activation RT domain and the basal transcription factor TFIIB RL Cell 75:519-530 (1993). RN [6] RA Malik S., Lee D. K., Roeder R. G. RT Potential RNA polymerase II-induced interactions of RT transcription factof TFIIB RL Mol. Cell. Biol. 13:6253-6259 (1993). RN [7] RA Babgy S., Kim S., Maldonado E., Tong K. I., Reinberg D., Ikura M. RT Solution structure of the C-terminal core domain of RT human TFIIB: similarity to Cyclin A and interaction RT with TATA -binding protein RL Cell 82:857-867 (1995). RN [8] RA Chi T., Lieberman P., Ellwood K., Carey M. RT A general mechanism for transcriptional synergy by eukaryotic activators RL Nature 377:254-257 (1995). RN [9] RA Sauer F., Fondell J. D., Ohkuma Y., Roeder R. G., Jaeckle H. RT Control of transcription by Krueppel through interactions RT with TFIIB and TFIIEbeta RL Nature 375:162-164 (1995). RN [10] RA Hadzic E., Desai-Yajnik V., Helmer E., Guo S., Wu RA S., Koudinova N., Casanova J., Raaka B. M., Samuels H. H. RT A 10-amino acid sequence in the N-terminal A/B Domain RT of thyroid hormone receptor alpha is essential for RT transcriptional activation and interaction with the RT general transcription factor TFIIB RL Mol. Cell. Biol. 15:4507-4517 (1995). RN [11] RA Haviv I., Vaizel D., Shaul Y. RT pX, the HBV-encoded coactivator, interacts with components RT of the transcription machinery and stimulates transcription RT in a TAF-independent manner RL EMBO J. 15:3413-3420 (1996). RN [12] RA Ha I., Lane W. S., Reinberg D. RT Cloning of a human gene encoding the general transcription RT initiation factor IIB RL Nature 352:689-695 (1991). RN [13] RA Malik S., Hisatake K., Sumimoto H., Horikoshi M., Roeder R. G. RT Sequence of general transcription factor TFIIB and RT relationships to other initiation factors RL Proc. Natl. Acad. Sci. USA 88:9553-9557 (1991). RN [14] RA Sharp P. RT TFIIB or not TFIIB RL Nature 351:16-18 (1991). RN [15] RA Imbalzano A. N., Zaret K. S., Kingston R. E. RT Transcription factor (TF) IIB and TFIIA can independently RT increase the affinity of the TATA-binding protein for DNA RL J. Biol. Chem. 269:8290-8286 (1994). RN [16] RA Lin Y.-S., Ha I., Maldonado E., Reinberg D., Green M. R. RT Binding of general transcription factor TFIIB to an acidic activating region RL Nature 353:569-571 (1991). RN [17] RA Lin Y.-S., Green M. R. RT Mechanism of action of an acidic transcriptional activator in vitro RL Cell 64:971-981 (1991). RN [18] RA Pinto I., Ware D. E., Hampsey M. RT The yeast SUA7 gene encodes a homolog of human transcription RT factor TFIIB and is required for normal start site selection in vivo RL Cell 68:977-988 (1992). RN [19] RA Hisatake K., Roeder R. G., Horikoshi M. RT Functional dissection of TFIIB domains required for RT TFIIB-TFIID-promoter complex formation and basal transcription activity RL Nature 363:744-747 (1993). RN [20] RA Roberts S. G. E., Ha I., Maldonado E., Reinberg D., Green M. R. RT Interaction between an acidic activator and transcription RT factor IIB is required for transcriptional activation RL Nature 363:741-744 (1993). RN [21] RA Ha I., Roberts S., Maldonado E., Sun X., Kim L.-U., Green M., Reinberg D. RT Multiple functional domains of human transcription RT factor IIB: distinct interactions with two general transcription factors RL Genes Dev. 7:1021-1032 (1993). RN [22] RA Barberis A., Mueller C. W., Harrison S. C., Ptashne M. RT Delineation of two functional regions of transcription factor TFIIB RL Proc. Natl. Acad. Sci. USA 90:5628-5632 (1993). RN [23] RA Buratowski S., Zhou H. RT Functional domains of transcription factor TFIIB RL Proc. Natl. Acad. Sci. USA 90:5633-5637 (1993). RN [24] RA Usheva A., Shenk T. RT TATA-binding protein-independent initiation: YY1, RT TFIIB, and RNA polymerase II direct basal transcription RT on supercoiled template DNA RL Cell 76:1115-1121 (1994). RN [25] RA Roberts S. G. E., Green M. R. RT Activator-induced conformational change in general RT transcription factor TFIIB RL Nature 371:717-720 (1994). RN [26] RA Abendroth F. D., Peterson S. R., Galman M., Suwa A., RA Hardin J. A., Dynan W. S. RT Identification of human autoantibodies to transcription factor IIB RL Nucleic Acids Res. 23:2770-2774 (1995). RN [27] RA Buratowski S., Sharp Ph. A. RT Transcription initiation complexes and upstream activation RT with RNA polymerase II lacking the C-terminal domain of the largest subunit RL Mol. Cell. Biol. 10:5562-5564 (1990). XX // AC T00819 XX ID T00819 XX DT 15.10.92 (created); ewi. DT 23.06.97 (updated); ewi. XX FA TFIIB XX SY SUA7; factor E; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 345 AA; 39.1 kDa (cDNA), 41 kDa (SDS) XX SQ MMTRESIDKRAGRRGPNLNIVLTCPECKVYPPKIVERFSEGDVVCALCGLVLSDKLVDTR SQ SEWRTFSNDDHNGDDPSRVGEASNPLLDGNNLSTRIGKGETTDMRFTKELNKAQGKNVMD SQ KKDNEVQAAFAKITMLCDAAELPKIVKDCAKEAYKLCHDEKTLKGKSMESIMAASILIGC SQ RRAEVARTFKEIQSLIHVKTKEFGKTLNIMKNILRGKSEDGFLKIDTDNMSGAQNLTYIP SQ RFCSHLGLPMQVTTSAEYTAKKCKEIKEIAGKSPITIAVVSIYLNILLFQIPITAAKVGQ SQ TLQVTEGTIKSGYKILYEHRDKLVDPQLIANGVVSLDNLPGVEKK XX SC SwissProt #P29055 XX FT 24 48 putative zinc finger FT 136 178 imperfect repeat FT 184 201 potential amphipathic alpha-helix FT 242 284 imperfect repeat XX IN T00794; TBP; human, Homo sapiens. XX BS R01016; AD$MLP_31; Quality: 6; adenovirus XX DR EMBL: M81380; SCSUA7A(g). DR SwissProt: P29055; TF2B_YEAST. DR PIR: S26707; S26707. XX RN [1] RA Amaya Y., Nakano A., Ito K., Mori M. RT Isolation of a yeast gene, SRH1, that encodes a homologue RT of the 54K subunit of mammalian signal recognition particle RL J. Biochem. 107:457-463 (1990). RN [2] RA Pinto I., Ware D. E., Hampsey M. RT The yeast SUA7 gene encodes a homolog of human transcription RT factor TFIIB and is required for normal start site selection in vivo RL Cell 68:977-988 (1992). RN [3] RA Knaus R., Pollock R., Guarente L. RT Yeast SUB1 is a suppressor of TFIIB mutations and RT has homology to the human co-activator PC4 RL EMBO J. 15:1933-1940 (1996). RN [4] RA Sun Z.-W., Hampsey M. RT Synthetic enhancement of a TFIIB defect by a mutation RT in SSU72, an essential yeast gene encoding a novel RT protein that affects transcription start site selection in vivo RL Mol. Cell. Biol. 16:1557-1566 (1996). RN [5] RA Sun Z.-W., Hampsey M. RT Identification of the gene (SSU71/TFG1) encoding the RT largest subunit of transcription factor TFIIF as a RT suppressor of a TFIIB mutation in Saccharomyces cerevisiae RL Proc. Natl. Acad. Sci. USA 92:3127-3131 (1995). RN [6] RA Tschochner H., Sayre M. H., Flanagan P. M., Feaver W. J., Kornberg R. D. RT Yeast RNA polymerase II initiation factor e: Isolation RT and identification as the functional counterpart of RT human transcription factor IIB RL Proc. Natl. Acad. Sci. USA 89:11292-11296 (1992). RN [7] RA Pinto I., Wu W.-H., Na J. G., Hampsey M. RT Characterization of sua7 mutations defines a domain RT of TFIIB involved in transcription start site selection in yeast RL J. Biol. Chem. 269:30569-30573 (1994). RN [8] RA Sun Z.-W., Tessmer A., Hampsey M. RT Functional interaction between TFIIB and the Rpb9 RT (Ssu73) subunit of RNA polymerase II in Saccharomyces cerevisiae RL Nucleic Acids Res. 24:2560-2566 (1996). RN [9] RA Buratowski S., Hahn S., Guarente L., Sharp P. A. RT Five Intermediate Complexes in Transcription Initiation by RNA Polymerase II RL Cell 56:549-561 (1989). XX // AC T00820 XX ID T00820 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA TFIID XX SY TAB; dTFIID; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO B factor (Dros.) XX SZ 120-140 kDa, 700-1000 kDa, 17S XX SF composition: TBP + TAF-250 + TAF-125 + TAF-95 + TAF-78 + TAF-50 XX FF TATA-box-binding complex of TBP and TAFs; FF can be competed by En XX IN T00815; TFIIA; yeast, Saccharomyces cerevisiae. IN T00816; TFIIA; wheat, Triticum aestivum. IN T00817; TFIIA; human, Homo sapiens. XX MX M00216; V$TATA_C XX BS R01764; AD$E1B_02; Quality: 6; adenovirus BS R00344; AD$E3_06; Quality: 6; adenovirus type 2 BS R00360; AD$E4_14; Quality: 6; adenovirus type 5 BS R00367; AD$E4_21; Quality: 6; adenovirus type 5 BS R03170; AD$IVA2_04; Quality: 6; adenovirus BS R00996; AD$MLP_11; Quality: 6; adenovirus BS R00998; AD$MLP_13; Quality: 6; adenovirus BS R00999; AD$MLP_14; Quality: 6; adenovirus BS R01002; AD$MLP_17; Quality: 6; adenovirus type 5 BS R01014; AD$MLP_29; Quality: 6; adenovirus BS R01015; AD$MLP_30; Quality: 6; adenovirus BS R01017; AD$MLP_32; Quality: 6; adenovirus BS R01018; AD$MLP_33; Quality: 6; adenovirus BS R01619; AD$MLP_36; Quality: 6; adenovirus BS R02014; CHICK$BAG_14; Quality: 6; chick, Gallus gallus BS R00759; DROME$HSP70_09; Quality: 6; fruit fly, Drosophila melanogaster BS R00705; HIV1$HIV1_12; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R03166; HS$GFAP_01; Quality: 6; human, Homo sapiens BS R00687; HS$HH4_08; Quality: 2; human, Homo sapiens BS R00770; HS$HSP70_11; Quality: 6; human, Homo sapiens XX RN [1] RA van Dyke M. W., Sawadogo M. RT DNA-binding and transcriptional properties of human RT transcription factor TFIID after mild proteolysis RL Mol. Cell. Biol. 10:3415-3420 (1990). RN [2] RA Schmidt M. C., Zhou Q., Berk A. J. RT Sp1 Activates Transcription without Enhancing DNA-Binding RT Activity of the TATA Box Factor RL Mol. Cell. Biol. 9:3299-3307 (1989). RN [3] RA Garcia J., Wu F., Gaynor R. RT Upstream regulatory regions required to stabilize RT binding to the TATA sequence in an adenovirus early promoter RL Nucleic Acids Res. 15:8367-8385 (1987). RN [4] RA Horikoshi M., Hai T., Lin Y.-S., Green M. R., Roeder R. G. RT Transcription factor ATF interacts with the TATA factor RT to facilitate establishment of a preinitiation complex RL Cell 54:1033-1042 (1989). RN [5] RA Wu B. J., Williams G. T., Morimoto R. I. RT Detection of three protein binding sites in the serum-regulated RT promoter of the human gene encoding the 70-kDa heat shock protein RL Proc. Natl. Acad. Sci. USA 84:2203-2207 (1987). RN [6] RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J. RT Holo-TFIID supports transcriptional stimulation by RT diverse activators and from a TATA-less promoter RL Genes Dev. 6:1964-1974 (1992). RN [7] RA Nakatani Y., Horikoshi M., Brenner M., Yamamoto T., RA Besnard F., Roeder R. G., Freese E. RT A downstream initiation element required for efficient RT TATA box binding and in vitro function of TFIID RL Nature 348:86-88 (1990). RN [8] RA Safer B., Reinberg D., Jacob W. F., Maldonado E., RA Carcamo J., Garfinkel S., Cohen R. RT Interaction of CAP sequence site binding factor and RT transcription factor IID preceding and following binding RT to the adenovirus 2 major late promoter RL J. Biol. Chem. 266:10989-10994 (1991). RN [9] RA Nakajima N., Horikoshi M., Roeder R. G. RT Factors Involved in Specific Transcription by Mammalian RT RNA Polymerase II: Purification, Gene Specificity, RT and TATA Box-Promoter Interactions of TFIID RL Mol. Cell. Biol. 8:4028-4040 (1988). RN [10] RA Sawadogo M., Roeder R. G. RT Interaction of a Gene-Specific Transcription Factor RT with the Adenovirus Major Late Promoter Upstream of the TATA Box Region RL Cell 43:165-175 (1985). RN [11] RA Ohkuma Y., Horikoshi M., Roeder R. G., Desplan C. RT Engrailed, a homeodomain protein, can repress in vitro RT transcription by competition with the TATA box-binding RT protein transcription factor IID RL Proc. Natl. Acad. Sci. USA 87:2289-2293 (1990). XX // AC T00821 XX ID T00821 XX DT 15.10.92 (created); ewi. XX FA TFIID XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX MX M00216; V$TATA_C XX BS R01943; CHICK$BG_01; Quality: 3; chick, Gallus gallus BS R01944; CHICK$BG_02; Quality: 3; chick, Gallus gallus BS R01167; CHICK$MLC2_03; Quality: 5; chick, Gallus gallus XX RN [1] RA Braun T., Tannich E., Buschhausen-Denker G., Arnold H.-H. RT Promoter Upstream Elements of the Chicken Cardiac RT Myosin Light-Chain 2-A Gene Interact with trans-Acting RT Regulatory Factors for Muscle-Specific Transcription RL Mol. Cell. Biol. 9:2513-2525 (1989). XX // AC T00822 XX ID T00822 XX DT 15.10.92 (created); ewi. DT 26.05.97 (updated); hiwi. XX FA TFIIE XX SY CB; CII; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX FF TFIIE is a heterotetramer composed of two subunits: FF TFIIE-alpha and TFII-beta XX BS R00996; AD$MLP_11; Quality: 6; adenovirus BS R01018; AD$MLP_33; Quality: 6; adenovirus XX DR EMBL: X63468; HSTFIIEA(r). DR EMBL: X63469; HSTFIIEB(r). DR SwissProt: P29083; T2EA_HUMAN. DR SwissProt: P29084; T2EB_HUMAN. XX RN [1] RA Horikoshi M., Hai T., Lin Y.-S., Green M. R., Roeder R. G. RT Transcription factor ATF interacts with the TATA factor RT to facilitate establishment of a preinitiation complex RL Cell 54:1033-1042 (1989). XX // AC T00823 XX ID T00823 XX DT 15.10.92 (created); ewi. DT 26.05.97 (updated); hiwi. XX FA TFIIE XX SY factor a; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 482 AA (alpha); 54.7 KDa (alpha) (cDNA), 66 kDa (alpha), 43 SZ kDa (beta) (SDS), 240-260 kDa (GF) XX SQ MDRPIDDIVKNLLKFVVRGFYGGSFVLVLDAILFHSVLAEDDLKQLLSINKTELGPLIAR SQ LRSDRLISIHKQREYPPNSKSVERVYYYVKYPHAIDAIKWKVHQVVQRLKDDLDKNSEPN SQ GYMCPICLTKYTQLEAVQLLNFDRTEFLCSLCDEPLVEDDSGKKNKEKQDKLNRLMDQIQ SQ PIIDSLKKIDDSRIEENTFEIALARLIPPQNQSHAAYTYNPKKGSTMFRPGDSAPLPNLM SQ GTALGNDSSRRAGANSQATLHINITTASDEVAQRELQERQAEEKRKQNAVPEWHKQSTIG SQ KTALGRLDNEEEFDPVVTASAMDSINPDNEPAQETSYQNNRTLTEQEMEERENEKTLNDY SQ YAALAKKQAKLNKEEEEEEEEEEDEEEEEEEEMEDVMDDNDETARENALEDEFEDVTDTA SQ GTAKTESNTSNDVKQESINDKTEDAVNATATASGPSANAKPNDGDDDDDDDDDEMDIEFE SQ DV XX SC SwissProt #P36100 XX DR EMBL: Z28028; SCYKL028W(g). DR SwissProt: P36100; T2EA_YEAST. DR PIR: S37845; S37845. XX RN [1] RA Sayre M. H., Tschochner H., Kornberg R. D. RT Purification and properties of Saccharomyces cerevisiae RT RNA polymerase II general initiation factor a RL J. Biol. Chem. 267:23383-23387 (1992). RN [2] RA Buratowski S., Hahn S., Guarente L., Sharp P. A. RT Five Intermediate Complexes in Transcription Initiation by RNA Polymerase II RL Cell 56:549-561 (1989). XX // AC T00824 XX ID T00824 XX DT 21.10.92 (created); ewi. XX FA TFII-I XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF binds to initiator regions (Inr), cooperates with USF XX BS R00992; AD$MLP_07; Quality: 6; adenovirus BS R02081; AD$MLP_37; Quality: 6; adenovirus XX RN [1] RA Roy A. L., Meisterernst M., Pognonec P., Roeder R. G. RT Cooperative interaction of an initiator-binding transcription RT initiation factor and the helix-loop-helix activator USF RL Nature 354:245-248 (1991). XX // AC T00825 XX ID T00825 XX DT 15.10.92 (created); ewi. XX FA Tf-LF1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX FF different from Tf-LF2 or LF-A1 XX BS R00113; HS$ANTHIII_01; Quality: 6; human, Homo sapiens BS R01457; HS$TF_08; Quality: 6; human, Homo sapiens XX RN [1] RA Ochoa A., Brunel F., Mendelzon D., Cohen G. N., Zakin M. M. RT Different liver nuclear proteins bind to similar sequences RT in the 5' flanking regions of three hepatic genes RL Nucleic Acids Res. 17:119-133 (1989). XX // AC T00826 XX ID T00826 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA Tf-LF1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO NF-BA1 XX CP (liver) XX BS R00140; HS$APOA2_05; Quality: 6; human, Homo sapiens BS R01457; HS$TF_08; Quality: 6; human, Homo sapiens XX RN [1] RA Ochoa A., Brunel F., Mendelzon D., Cohen G. N., Zakin M. M. RT Different liver nuclear proteins bind to similar sequences RT in the 5' flanking regions of three hepatic genes RL Nucleic Acids Res. 17:119-133 (1989). RN [2] RA Lucero M. A., Sanchez D., Ochoa A. R., Brunel F., RA Cohen G. N., Baralle F. E., Zakin M. M. RT Interaction of DNA-binding proteins with the tissue-specific RT human apolipoprotein-AII enhancer RL Nucleic Acids Res. 17:2283-2300 (1989). XX // AC T00827 XX ID T00827 XX DT 15.10.92 (created); ewi. DT 12.07.94 (updated); ewi. XX FA Tf-LF2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (liver) XX FF different from Tf-LF1 XX BS R01454; HS$TF_05; Quality: 6; human, Homo sapiens XX RN [1] RA Ochoa A., Brunel F., Mendelzon D., Cohen G. N., Zakin M. M. RT Different liver nuclear proteins bind to similar sequences RT in the 5' flanking regions of three hepatic genes RL Nucleic Acids Res. 17:119-133 (1989). XX // AC T00828 XX ID T00828 XX DT 15.03.93 (created); ewi. XX FA TF-Vbeta XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX BS R01582; CHICK$VIT2_15; Quality: 4; chick, Gallus gallus XX RN [1] RA Seal S. N., Davis D. L., Burch J. B. E. RT Mutational studies reveal a complex set of positive RT and negative control elements within the chicken vitellogenin II promoter RL Mol. Cell. Biol. 11:2704-2717 (1991). XX // AC T00829 XX ID T00829 XX DT 03.12.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA TGA1a XX SY ASF-1; XX OS tobacco, Nicotiana tabacum OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC asteridae; solanes; solanaceae XX CL C0008; bZIP; 1.1.5.5.1. XX SZ 359 AA; 41 kDa (cDNA) XX SQ MGICDPIHQLGMWDDFNSSFPSTSATMILEVDKCLEDQIPIMEKRLDNETEDTSHGTVGT SQ SNRYEPETSKPVEKVLRRLAQNREAARKSRLRKKAYVQQLENSKLKLIQLEQELERARKQ SQ GMCVGGGVDASQLSYSGTASSGTAVFDMEYGHWVEEQTRQTNDLRIALHSQIGEAELRII SQ VDGYLNHYFDLFRMKATAAKADVLYIMSGMWKTSAERFFMWIGGFRPSELLKVLTPHLEL SQ LTEQQLREVCNLTQSCQQAEDALSQGMVKLHQILAEAVAAGRLGEGNYTLPQMGPAIEKL SQ EDLVRFVNQADHLRQETLQQMSRILNTCQAAQGLLALGEYFERLRVLSSQWATRLREPT XX SC SwissProt #P14232 XX FT 144 373 DS region (dimer stabilization) XX SF L3 SF glutamine-rich region, acidic region SF 373 AA [1]; XX BS R00009; CAMV$35SR_01; Quality: 6; CaMV, cauliflower mosaic virus BS R01174; TDNA$NOS_01; Quality: 6; Agrobacterium tumefaciens BS R00679; WHEAT$H3_01; Quality: 6; wheat, Triticum aestivum XX DR EMBL: X16449; NICTGA1A(r). DR SwissProt: P14232; TGAA_TOBAC. XX RN [1] RA Katagiri F., Seipel K., Chua N.-H. RT Identification of a novel dimer stabilization region RT in a plant bZIP transcription activator RL Mol. Cell. Biol. 12:4809-4816 (1992). RN [2] RA Katagiri F., Lam E., Chua N.-H. RT Two tobacco DNA-binding proteins with homology to the nuclear factor CREB RL Nature 340:727-730 (1989). XX // AC T00830 XX ID T00830 XX DT 03.12.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA TGA1b XX SY ASF-1; XX OS tobacco, Nicotiana tabacum OC eukaryota; plantae; embryobionta; magnoliophyta; magnoliopsida; OC asteridae; solanes; solanaceae XX CL C0008; bZIP; . XX SZ >242 AA XX SQ EFCDFSGNQAAGGVMVMDTSSPELRQSSSGSDVLNATSSTSSHQVSGDVAGYLNVPSPES SQ NGSNHEGSRESANDNKGLGDARVLNCHSPESQGSGNYGSNVSEGLNYPSDSNKSVHSSPN SQ FENNSIKNGAVEEKIKLEGVNANISKCSSLLKRKKSSEDSNNINIHQKLTNVALSDNVNN SQ DEDEKKRARLVRNRESAQLSRQRKKHYVEELEDKVRIMHSTIQDLNAKVAYIIAENATLK SQ TQ XX SC SwissProt #P14233 XX SF LMLIL SF serine-rich region XX BS R00009; CAMV$35SR_01; Quality: 6; CaMV, cauliflower mosaic virus BS R01174; TDNA$NOS_01; Quality: 6; Agrobacterium tumefaciens BS R00679; WHEAT$H3_01; Quality: 6; wheat, Triticum aestivum XX DR EMBL: X16450; NICTGA1B(r). DR SwissProt: P14233; TGAB_TOBAC. XX RN [1] RA Katagiri F., Lam E., Chua N.-H. RT Two tobacco DNA-binding proteins with homology to the nuclear factor CREB RL Nature 340:727-730 (1989). XX // AC T00831 XX ID T00831 XX DT 12.03.93 (created); ewi. XX FA TgF1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (thyroid) XX FF reduced upon exposure to KiMSV Ras, regained upon 5-azacytidine treatment XX BS R01882; RAT$TG_09; Quality: 3; rat, Rattus norvegicus XX RN [1] RA Avvedimento V. E., Musti A. M., Ueffing M., Obici RA S., Gallo A., Sanchez M., DeBrasi D., Gottesmann M. E. RT Reversible inhibition of a thyroid-specific trans-acting factor by Ras RL Genes Dev. 5:22-28 (1991). XX // AC T00832 XX ID T00832 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA TGGCA-binding protein XX SY CTF; NF-1; NF-I; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX SZ 29.8-36.8 kDa (SDS) XX SF 4 genes, many splice variants XX BS R00532; CHICK$BAG_06; Quality: 6; chick, Gallus gallus BS R01945; CHICK$BG_03; Quality: 3; chick, Gallus gallus BS R00537; CHICK$BHG_03; Quality: 4; chick, Gallus gallus BS R02588; CHICK$LYS_24; Quality: 1; chick, Gallus gallus BS R01126; MMTV$MMTV_28; Quality: 6; MMTV, mouse mammary tumor virus BS R02209; NF1$CONS; Quality: 6 XX RN [1] RA Nowock J., Borgmeyer U., Pueschel A. W., Rupp R. A. W., Sippel A. E. RT The TGGCA protein binds to the MMTV-LTR, the adenovirus RT origin of replication, and the BK virus enhancer RL Nucleic Acids Res. 13:2045-2061 (1985). RN [2] RA Rupp R. A. W., Sippel A. E. RT Chicken liver TGGCA protein purified by preparative RT mobility shift electrophoresis (PMSE) shows a 36.8 RT to 29.8 kd microheterogeneity RL Nucleic Acids Res. 15:9707-9726 (1987). RN [3] RA Rupp R. A. W., Nicolas R. H., Borgmeyer U., Lobanenkov RA V. V., Plumb M. A., Sippel A. E., Goodwin G. H. RT TGGCA protein is present in erythroid nuclei and binds RT within the nuclease-hypersensitive sites 5' of the RT chicken betaH- and betaA-globin genes RL Eur. J. Biochem. 177:505-511 (1988). XX // AC T00833 XX ID T00833 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA TGT3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO EF-C, C/EBP XX BS R00638; HBV$HBVE_09; Quality: 6; HBV, human hepatitis B virus BS R02680; HS$APOB_04; Quality: 6; human, Homo sapiens BS R02254; TGT3$CONS; Quality: 6 XX RN [1] RA Paulweber B., Onasch M. A., Nagy B. P., Levy-Wilson B. RT Similarities and differences in the function of regulatory RT elements at the 5' end of the human apolipoprotein RT B gene in cultured hepatoma (HepG2) and colon carcinoma (CaCo-2) cells RL J. Biol. Chem. 266:24149-24160 (1991). RN [2] RA Ben-Levy R., Faktor O., Berger I., Shaul Y. RT Cellular Factors That Interact with the Hepatitis B Virus Enhancer RL Mol. Cell. Biol. 9:1804-1809 (1989). XX // AC T00834 XX ID T00834 XX DT 27.01.93 (created); hse. XX FA TIN-1 XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX SZ 43, 45 kDa (SDS) XX CP testis XX FF acts as transcriptional inhibitor XX BS R03356; MOUSE$PGK1_01; Quality: 6; mouse, Mus musculus BS R02255; TIN1$CONS; Quality: 6 XX RN [1] RA Goto M., Tamura T., Mikoshiba K., Masamune Y., Nakanishi Y. RT Transcription inhibition of the somatic-type phosphoglycerate RT kinase 1 gene in vitro by a testis-specific factor RT that recognizes a sequence similar to the binding site for Ets oncoproteins RL Nucleic Acids Res. 19:3959-3963 (1991). XX // AC T00835 XX ID T00835 XX DT 16.04.93 (created); ewi. DT 23.05.97 (updated); hiwi. XX FA TMF XX SY TATA element modulatory factor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 1093 AA; 123.2 kDa (cDNA) XX SQ MSWFNASQLSSFAKQALSQAQKSIDRVLDIQEEEPSIWAETIPYGEPGISSPVSGGWDTS SQ TWGLKSNTEPQSPPIASPKAITKPVRRTVVDESENFFSAFLSPTDVQTIQKSPVVSKPPA SQ KSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEET SQ VNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSN SQ TPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASA SQ CPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIV SQ NSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEG SQ QTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFD SQ NLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLN SQ SSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKEL SQ EEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAAL SQ DSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGD SQ LRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQA SQ TLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQ SQ ENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERM SQ KVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHS SQ FGPMPISAKWKHLYAACKDGSRIKHIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEE SQ LVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMY SQ KTQIDELLRQSLS XX SC PIR #A47212 XX FT 454 482 putative leucine zipper (LRL3) FT 558 607 putative leucine zipper (L2NLNL3) FT 704 787 similar to Ner(1-73) [1]; FT 1041 1069 putative leucine zipper (L2IKL) XX SF 3 putative leucine zippers XX FF binds to the TATA box of HIV-1 and inhibits activation by TBP XX BS R00705; HIV1$HIV1_12; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R00687; HS$HH4_08; Quality: 6; human, Homo sapiens BS R01590; XENLA$VITB1_04; Quality: 6; clawed frog, Xenopus laevis XX DR EMBL: L01042; HSHIVMF(r). DR PIR: A47212; A47212. XX RN [1] RA Garcia J. A., Ou S.-H. I., Wu F., Lusis A. J., Sparkes R. S., Gaynor R. B. RT Cloning and chromosomal mapping of a human immunodeficiency RT virus 1 TATA element modulatory factor RL Proc. Natl. Acad. Sci. USA 89:9372-9376 (1992). XX // AC T00836 XX ID T00836 XX DT 28.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA T3R XX SY c-ErbA; thyroid hormone receptor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); . XX SZ 410 AA; 46 kDa XX SQ MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCPLKSSMSGYIPSYLDKDEQCVVCGDKA SQ TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM SQ AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHVATEAHRSTNA SQ QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS SQ ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF SQ ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI SQ PHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV XX SC SwissProt #P16416 XX SF phosphorylation SF two splice variants (T3R-alpha1 and -alpha2) XX FF member of the steroid hormone receptor superfamily XX IN T00716; RAR; monkey, Cercopithecus aethiops. IN T00717; RAR; mouse, Mus musculus. IN T00718; RAR; cat, Felis catus. IN T00719; RAR-alpha1; human, Homo sapiens. IN T00720; RAR-gamma; human, Homo sapiens. XX BS R03523; TR$CONS_02; Quality: 6 XX DR EMBL: X51983; MMCERBA(r). DR SwissProt: P16416; THA1_MOUSE. XX RN [1] RA Baniahmad A., Steiner C., Koehne A. C., Renkawitz R. RT Modular structure of a chicken lysozyme silencer: RT involvement of an unusual thyroid hormone receptor binding site RL Cell 61:505-514 (1990). RN [2] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [3] RA Lazar M. A., Berrodin T. J., Harding H. P. RT Differential DNA binding by monomeric, homodimeric, RT and potentially heteromeric forms of the thyroid hormone receptor RL Mol. Cell. Biol. 11:5005-5015 (1991). XX // AC T00837 XX ID T00837 XX DT 15.10.92 (created); ewi. DT 24.10.94 (updated); hse; ewi. XX FA T3R XX SY c-ErbA; thyroid hormone receptor; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0002; CC (rec); . XX SZ 46 kDa XX IN T00716; RAR; monkey, Cercopithecus aethiops. IN T00717; RAR; mouse, Mus musculus. IN T00718; RAR; cat, Felis catus. IN T00719; RAR-alpha1; human, Homo sapiens. IN T00720; RAR-gamma; human, Homo sapiens. XX BS R02019; AS$TR_02; Quality: 1 BS R01673; CHICK$LYS_15; Quality: 1; chick, Gallus gallus BS R03956; HS$CSB_02; Quality: 1; human, Homo sapiens BS R02595; MOMLV$MOMULV_19; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R03523; TR$CONS_02; Quality: 6 XX RN [1] RA Sap J., Munoz A., Damm K., Goldberg Y., Ghysdael J., RA Leutz A., Beug H., Vennstroem B. RT The c-erb-A protein is a high-affinity receptor for thyroid hormone RL Nature 324:635-640 (1986). RN [2] RA Baniahmad A., Steiner C., Koehne A. C., Renkawitz R. RT Modular structure of a chicken lysozyme silencer: RT involvement of an unusual thyroid hormone receptor binding site RL Cell 61:505-514 (1990). RN [3] RA Sap J., Munoz A., Schmitt J., Stunnenberg H., Vennstroem B. RT Repression of transcription mediated at a thyroid RT hormone response element by the v-erb-A oncogene product RL Nature 340:242 (1989). RN [4] RA Forrest D., Hallboeoek F., Persson H., Vennstroem B. RT Distinct functions for thyroid hormone receptors alpha RT and beta in brain development indicated by differential RT expression of receptor genes RL EMBO J. 10:269-275 (1991). RN [5] RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone RT receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [6] RA Lazar M. A., Berrodin T. J., Harding H. P. RT Differential DNA binding by monomeric, homodimeric, RT and potentially heteromeric forms of the thyroid hormone receptor RL Mol. Cell. Biol. 11:5005-5015 (1991). XX // AC T00838 XX ID T00838 XX DT 15.10.92 (created); ewi. DT 06.04.94 (updated); hwi; hse. XX FA T3R XX SY c-ErbA; thyroid hormone receptor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); . XX SZ 52; 55; 46 kDa (SDS) XX IN T00716; RAR; monkey, Cercopithecus aethiops. IN T00717; RAR; mouse, Mus musculus. IN T00718; RAR; cat, Felis catus. IN T00719; RAR-alpha1; human, Homo sapiens. IN T00720; RAR-gamma; human, Homo sapiens. XX BS R02595; MOMLV$MOMULV_19; Quality: 1; Mo-MuLV, moloney murine leukemia virus BS R03899; RAT$BMHC_01; Quality: 5; rat, Rattus norvegicus BS R00624; RAT$GRH_18; Quality: 1; rat, Rattus norvegicus BS R03523; TR$CONS_02; Quality: 6 XX DR EMBL: X55072; HSCERBA1(g). DR EMBL: X55066; HSCERBA10(g). DR EMBL: X55074; HSCERBA2(g). DR EMBL: X55073; HSCERBA3(g). DR EMBL: X55070; HSCERBA4(g). DR EMBL: X55071; HSCERBA5(g). DR EMBL: X55004; HSCERBA7(g). DR EMBL: X55069; HSCERBA8(g). DR EMBL: X55068; HSCERBA9(g). DR EMBL: X55005; HSCERBAR(r). DR EMBL: X04707; HSERBAR(r). DR EMBL: Y00479; HSERBT1(r). DR EMBL: M24748; HSTHRA1A(g). DR EMBL: J03239; HSTHRA2A(r). DR EMBL: J03239; HSTHRA2A(r). DR SwissProt: P21205; THA1_HUMAN. DR SwissProt: P10827; THA2_HUMAN. DR SwissProt: P10828; THB1_HUMAN. DR SwissProt: P37243; THB2_HUMAN. XX RN [1] RA Weinberger C., Thompson C. C., Ong E. S., Lebo R., Gruol D. J., Evans R. M. RT The c-erb-A gene encodes a thyroid hormone receptor RL Nature 324:641-646 (1986). RN [2] RA Baniahmad A., Steiner C., Koehne A. C., Renkawitz R. RT Modular structure of a chicken lysozyme silencer: RT involvement of an unusual thyroid hormone receptor binding site RL Cell 61:505-514 (1990). RN [3] RA Laudet V., Begue A., Henry-Duthoit C., Joubel A., RA Martin P., Stehelin D., Saule S. RT Genomic organization of the human thyroid hormone RT receptor alpha (c-erbA-1) gene RL Nucleic Acids Res. 19:1105-1112 (1991). RN [4] RA Lazar M. A., Berrodin T. J., Harding H. P. RT Differential DNA binding by monomeric, homodimeric, RT and potentially heteromeric forms of the thyroid hormone receptor RL Mol. Cell. Biol. 11:5005-5015 (1991). XX // AC T00839 XX ID T00839 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA T3R XX SY c-ErbA; thyroid hormone receptor; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); . XX SZ 46 kDa (SDS) XX SF phosphorylation XX FF member of the steroid hormone receptor superfamily XX IN T00716; RAR; monkey, Cercopithecus aethiops. IN T00717; RAR; mouse, Mus musculus. IN T00718; RAR; cat, Felis catus. IN T00719; RAR-alpha1; human, Homo sapiens. IN T00720; RAR-gamma; human, Homo sapiens. XX BS R03192; HS$CS1_04; Quality: 1; human, Homo sapiens BS R03956; HS$CSB_02; Quality: 6; human, Homo sapiens BS R03958; HS$GHA_11; Quality: 1; human, Homo sapiens BS R00614; RAT$GRH_08; Quality: 2; rat, Rattus norvegicus BS R00615; RAT$GRH_09; Quality: 2; rat, Rattus norvegicus BS R00617; RAT$GRH_11; Quality: 5; rat, Rattus norvegicus BS R00619; RAT$GRH_13; Quality: 1; rat, Rattus norvegicus BS R00621; RAT$GRH_15; Quality: 2; rat, Rattus norvegicus BS R04018; RAT$PEPCK_18; Quality: 4; rat, Rattus norvegicus BS R03523; TR$CONS_02; Quality: 6 XX RN [1] RA Baniahmad A., Steiner C., Koehne A. C., Renkawitz R. RT Modular structure of a chicken lysozyme silencer: RT involvement of an unusual thyroid hormone receptor binding site RL Cell 61:505-514 (1990). RN [2] RA Ye Z.-S., Samuels H. H. RT Cell- and Sequence-specific Binding of Nuclear Proteins RT to 5'-Flanking DNA of the Rat Growth Hormone Gene RL J. Biol. Chem. 262:6313-6317 (1987). RN [3] RA Tansey W. P., Catanzaro D. F. RT Sp1 and thyroid hormone receptor differentially activate RT expression of human growth hormone and chorionic somatomammotropin genes RL J. Biol. Chem. 266:9805-9813 (1991). RN [4] RA Lazar M. A., Berrodin T. J., Harding H. P. RT Differential DNA binding by monomeric, homodimeric, RT and potentially heteromeric forms of the thyroid hormone receptor RL Mol. Cell. Biol. 11:5005-5015 (1991). XX // AC T00840 XX ID T00840 XX DT 15.10.92 (created); ewi. DT 06.04.94 (updated); hwi; ewi. XX FA T3R XX SY c-ErbA; thyroid hormone receptor; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); . XX SZ 55, 46 kDa XX FF two isoforms (alpha, beta) with two splice variants each XX IN T00716; RAR; monkey, Cercopithecus aethiops. IN T00717; RAR; mouse, Mus musculus. IN T00718; RAR; cat, Felis catus. IN T00719; RAR-alpha1; human, Homo sapiens. IN T00720; RAR-gamma; human, Homo sapiens. XX BS R03523; TR$CONS_02; Quality: 6 XX DR EMBL: J03933; RNCERBAB(r). DR EMBL: M18028; RNTHR(r). DR EMBL: X07409; RNTRAVI(r). DR SwissProt: P10685; THA1_RAT. DR SwissProt: P15827; THA2_RAT. DR SwissProt: P18113; THB1_RAT. XX RN [1] RA Lavin T. N., Baxter J. D., Horita S. RT The Thyroid Hormone Receptor binds to Multiple Domains RT of the Rat Growth Hormone 5'-Flanking Sequence RL J. Biol. Chem. 263:9418-9426 (1988). RN [2] RA Ye Z.-S., Samuels H. H. RT Cell- and Sequence-specific Binding of Nuclear Proteins RT to 5'-Flanking DNA of the Rat Growth Hormone Gene RL J. Biol. Chem. 262:6313-6317 (1987). RN [3] RA Koenig R. J., Brent G. A., Warne R. L., Larsen P. R., Moore D. D. RT Thyroid hormone receptor binds to a site in the rat RT growth hormone promoter required for induction by thyroid hormone RL Proc. Natl. Acad. Sci. USA 84:5670-5674 (1987). RN [4] RA Glass C. K., Holloway J. M., Devary O. V., Rosenfeld M. G. RT The thyroid hormone receptor binds with opposite transcriptional RT effects to a common sequence motif in thyroid hormone RT and estrogen response elements RL Cell 54:313-323 (1988). XX // AC T00841 XX ID T00841 XX DT 15.10.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA T3R-alpha XX SY c-ErbAalpha; thyroid hormone receptor-alpha; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.2.3.1.1. XX SZ 410 AA; 46.8 kDa / 490 AA; 54.8 kDa XX SF two splice variants alpha1 and alpha2 XX FF T3-binding with KD = 0.4 nM (alpha1); FF may enhance transcriptional activation by c-Jun XX IN T00719; RAR-alpha1; human, Homo sapiens. IN T01331; RXR-alpha; mouse, Mus musculus. IN T01345; RXR-alpha; human, Homo sapiens. XX BS R01465; AS$TR_01; Quality: 1 BS R01673; CHICK$LYS_15; Quality: 1; chick, Gallus gallus BS R03942; HS$CAMHC_01; Quality: 6; human, Homo sapiens BS R03102; HS$TSHB_03; Quality: 6; human, Homo sapiens BS R02595; MOMLV$MOMULV_19; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R03886; MOUSE$MBP_06; Quality: 1; mouse, Mus musculus BS R00619; RAT$GRH_13; Quality: 6; rat, Rattus norvegicus BS R03959; RAT$GRH_23; Quality: 2; rat, Rattus norvegicus BS R01617; RAT$ME_01; Quality: 1; rat, Rattus norvegicus BS R02694; RAT$S14_03; Quality: 1; rat, Rattus norvegicus BS R02695; RAT$S14_04; Quality: 1; rat, Rattus norvegicus BS R02696; RAT$S14_05; Quality: 1; rat, Rattus norvegicus BS R03523; TR$CONS_02; Quality: 6 XX DR EMBL: M18028; RNTHR(r). DR EMBL: X07409; RNTRAVI(r). DR SwissProt: P10685; THA1_RAT. DR SwissProt: P15827; THA2_RAT. XX RN [1] RA Sharif M., Privalsky M. L. RT V-erbA and c-erbA proteins enhance transcriptional activation by c-jun RL Oncogene 7:953-960 (1992). RN [2] RA Petty K. J., Desvergne B., Mitsuhashi T., Nikodem V. M. RT Identification of a thyroid hormone response element RT in the malic enzyme gene RL J. Biol. Chem. 265:7395-7400 (1990). RN [3] RA Damm K., Thompson C. C., Evans R. M. RT Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist RL Nature 339:593-597 (1989). RN [4] RA Izumo S., Mahdavi V. RT Thyroid hormone receptor alpha isoforms generated RT by alternative splicing differentially activate myosin HC gene transcription RL Nature 334:539-542 (1988). RN [5] RA Murray M. B., Zilz N. D., McCreary N. L., MacDonald M. J., Towle H. C. RT Isolation and characterization of rat cDNA clones RT for two distinct thyroid hormone receptors RL J. Biol. Chem. 263:12770-12777 (1988). RN [6] RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA RT oncogene is in part due to a mutation in the DNA binding RT domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). XX // AC T00842 XX ID T00842 XX DT 10.11.92 (created); ewi. DT 27.08.96 (updated); ewi. XX FA Tra-1 (long form) XX OS Caenorhabditis elegans OC eukaryota; animalia; eumetazoa; nematoda; secernentea; OC rhabditia; rhabditida; rhabditina; rhabditoidea; rhabditidae XX CL C0001; CH; 2.3.2.3.4.1. XX SZ 1110 AA; 122.8 kDa (cDNA) XX SQ MMAPSTEDPDTVVEAQRRGSFSKKKNANGWNKVELVDQCAKQMGSEDKQPGGGDVKTEND SQ PSKNGLGSATSNFIQSSVPPSHQTLSNPLQLSPPAEASVAQQSGASQVFPTFQAALGASS SQ DELLQPNATSSSTSSSASTSSIVPVVKFTNQTAPNGSTVATSVGQNVRLTINGKRVGRPP SQ GTFKRPQNNAANSSNSGNDSDMMGDHDLTCRWKSCNSSFQTLKALVDHVQESHVQSTEQE SQ HHAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTH SQ TGEKPYKCEFADCEKAFSNASDRAKHQNRTHSNLKPYSCQIPQCTKSYTDPSSLRKHIKA SQ VHGDDEYEKAKKSRPANYSNRRRPDHRLAPPTGAMSHPYLATPNSGASVVAHSSVHQQNF SQ INMALAQHHHNAQRAQQLMAATGNVMPMMDPASAAAAAQAQAHHQAQAQMLQTHMMQQAQ SQ IQAAAQMQAQVQHQAAMQAHAMQQAQMVLQNNLLGAQSLLSPFSPLLPPSRAPNVMAMLQ SQ TPPTPTSVAPMFDIMTSRAPMAPVVSAPTAPAPLVPAPVPASPVFDELREQMREVEPLQQ SQ QQQQEPMDQDLQDIRVDGDSDDEDEEEPRTPSGALLLPRGGNNGDGGFGGSGSSRASSGS SQ GTMELSAAPISQNGSRASGSGERGMRSFLIADILQLAADFQNERLLSDVLDLAIFDTRDV SQ RSLHNIYQVYIRAHKAIPITRRPLDWNETHQLHNLYHDPRFNRAEHQDSPAIRDRDTRFW SQ RTIAEANTMRQRQIEPVPLDDDDEGYFDEMVHRVQNGRLNEQFMEGFESDDDDGFEDEDD SQ VPGLGIAVYRGRRRVRREALKQANLDIQEAETAGRNVGGFGDEEDRNNRGHDQDRSFLDH SQ YYPPMVVVVETESPQIVRDQEMMRQFEEAKKNVETDEIKKRAEAMQFGTSSSHHHTKTLL SQ IQRALFDKTSSVRRSLLQFITISVDQEELRQSCHATSAPQGAHVVHNVVDEFDSIMRAQE SQ DSNNRILLSLDIPAPSAVTGVSGSITHADNSALQLQQEQPTSSFSSWFPEDDPIYALPPP SQ PPPPAPPRRRRSADNKDDSENIPKKPRHQF XX SC SwissProt #P34708 XX SF 5 zinc finger motifs SF alanine-rich region, glutamine-rich region, acidic region XX FF terminal control gene for somatic sex determination XX DR SwissProt: P34708; TRA1_CAEEL. DR PIR: A43253; A43253. XX RN [1] RA Zarkower D., Hodgkin J. RT Molecular analysis of the C. elegans sex-determining RT gene tra-1: A gene encoding two Zinc finger proteins RL Cell 70:237-249 (1992). XX // AC T00843 XX ID T00843 XX DT 03.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Ttk 69K XX SY Tramtrack 69K; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.0.2.1. XX SZ 641 AA; 69 kDa XX SQ MASQRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLF SQ VSHPEKHPIVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDD SQ KPSPAAAAAGAGATGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQ SQ PSLLSSALMPKRKRGRPRKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGND SQ DGSDDNQPNAGHTDDLNESRDSLPSKRSKNSKDHRVVSHHEDNSTSDGNDSDGEGLDTSY SQ MEPQLMLDEYDEPVEFKYNPLTDNSSPTQDHTDGSHLNEQARQQAFLIAAQRKHQVETAA SQ AAAASGIKLNIIGMAAGGAQVKSMVSIPKLTPIGKVNAASTPLVSPAGSFSTATVKPRVQ SQ KRPKLGKQNGDVKPAVFSSQEYLDIYNSNDGFKLKAAGLSGSTPNLSAGLGTPSVKTKLN SQ LSSNVGEGEAEGSVRDYCTKEGEHTYRCKVCSRVYTHISNFCRHYVTSHKRNVKVYPCPF SQ CFKEFTRKDNMTAHVKIIHKIENPSTALATVAAANLAGQPLGVSGASTPPPPDLSGQNSN SQ QSLPATSNALSTSSSSSTSSSSGSLGPLTTSAPPAPAAAAQ XX SC SwissProt #P17789 XX SF 2 zinc finger motifs SF serine-/threonine-rich region XX CP stage 3 embryos (and earlier); re-appearing during CP stages 7 to 16 in distinct regions; very weakly expressed CP in larvae and adults XX FF repressor of ftz, eve XX MX M00009; I$TTK69_01 XX BS R02286; DROME$FTZ_06; Quality: 6; fruit fly, Drosophila melanogaster BS R02287; DROME$FTZ_07; Quality: 6; fruit fly, Drosophila melanogaster XX DR EMBL: M62856; DMFTZF2(r). DR EMBL: X17121; DMTTKFTZ(r). DR SwissProt: P17789; TTK_DROME. DR Flybase: FBgn0003870; ttk. DR PDB: 2drp; TRAMTRACK PROTEIN (TWO ZINC-FINGER PEPTIDE) COMPLEXED WITH DNA DROSOPHILA MELANOGASTER. XX RN [1] RA Read D., Manley J. L. RT Alternatively spliced transcripts of the Drosophila RT tramtrack gene encode zinc finger proteins with distinct RT DNA binding specificities RL EMBO J. 11:1035-1044 (1992). RN [2] RA Harrison S. D., Travers A. A. RT The tramtrack gene encodes a Drosophila finger protein RT that interacts with the ftz transcriptional regulatory RT region and shows a novel embryonic expression pattern RL EMBO J. 9:207-216 (1990). XX // AC T00844 XX ID T00844 XX DT 03.11.92 (created); ewi. DT 27.08.96 (updated); ewi. XX FA Ttk 88K XX SY TCCT-factor; Tramtrack 88K; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0001; CH; 2.3.2.0.2.2. XX SZ 811 AA; 88.2 kDa XX SQ MASQRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLF SQ VSHPEKHPIVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDD SQ KPSPAAAAAGAGATGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQ SQ PSLLSSALMPKRKRGRPRKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGND SQ DGSDDNQPNAGHTDDLNESRDSLPSKRSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRL SQ FGSSSTTISATAPGGSSTGPSETISLLEISDERESAPVHLPTILGLKIRAINTTTRAQQG SQ SPQTPTKSKPKIRQATGSNNSNSLLKQQLRGGAKDPEVPPATRITGAVTPNAALNAEEQS SQ KEMPKKNQDEVNACIGLHSLANAAEQQAAQVASTGNLHHQLLLHMAANNSMLNTTDYYQQ SQ QQQESPSSAGQFMDDDLELLSLNDQQDKSDEPDHEMVTLADQNAGLPGYQGNEAEATPAQ SQ EDSPAAETATAPPPAPRSGKKGAKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRY SQ ASVVEGVYRCTECAKENMQKTFKNKYSFQRHAFLYHEGKHRKVFPCPVCSKEFSRPDKMK SQ NHLKMTHENFTPPKDIGAFSPLKYLISAAAAGDMHATIYQQQQDHYHRQLAEQLEQQNAS SQ FDSRDSSLILPDVKMEHAEDQDAEQEAELSDGGYDASNPAAAAAAMLSLQQDVIIKDEIQ SQ ISPSPSPTPPASCAVAEGKSLALASTAQTAT XX SC SwissProt #P42282 XX SF 2 zinc finger motifs SF serine-/threonine-rich region XX FF repressor of en XX BS R02272; DROME$EN_08; Quality: 6; fruit fly, Drosophila melanogaster BS R02057; DROME$EVE_03; Quality: 6; fruit fly, Drosophila melanogaster BS R02060; DROME$EVE_06; Quality: 6; fruit fly, Drosophila melanogaster BS R02061; DROME$EVE_07; Quality: 6; fruit fly, Drosophila melanogaster BS R02273; TTK88$CONS; Quality: 6 XX DR EMBL: Z11723; DMDNABPMR(r). DR EMBL: X71626; DMTRAMT88(r). DR SwissProt: P42282; TTKA_DROME. DR Flybase: FBgn0003870; ttk. DR PDB: 2drp; TRAMTRACK PROTEIN (TWO ZINC-FINGER PEPTIDE) COMPLEXED WITH DNA DROSOPHILA MELANOGASTER. XX RN [1] RA Read D., Manley J. L. RT Alternatively spliced transcripts of the Drosophila RT tramtrack gene encode zinc finger proteins with distinct RT DNA binding specificities RL EMBO J. 11:1035-1044 (1992). XX // AC T00845 XX ID T00845 XX DT 10.11.92 (created); ewi. DT 27.08.96 (updated); ewi. XX FA Tra-1 (short form) XX OS Caenorhabditis elegans OC eukaryota; animalia; eumetazoa; nematoda; secernentea; OC rhabditia; rhabditida; rhabditina; rhabditoidea; rhabditidae XX CL C0001; CH; 2.3.2.3.4.2. XX SZ 288 AA; 30.9 kDa (cDNA) XX SQ MMAPSTEDPDTVVEAQRRGSFSKKKNANGWNKVELVDQCAKQMGSEDKQPGGGDVKTEND SQ PSKNGLGSATSNFIQSSVPPSHQTLSNPLQLSPPAEASVAQQSGASQVFPTFQAALGASS SQ DELLQPNATSSSTSSSASTSSIVPVVKFTNQTAPNGSTVATSVGQNVRLTINGKRVGRPP SQ GTFKRPQNNAANSSNSGNDSDMMGDHDLTCRWKSCNSSFQTLKALVDHVQESHVQSTEQE SQ HHAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEVGFGGDNEI XX SC PIR #B43253 XX SF 2 zinc finger motifs SF splice variant of Tra-1 (long form) XX DR EMBL: M94130; CETRA1B(r). DR PIR: B43253; B43253. XX RN [1] RA Zarkower D., Hodgkin J. RT Molecular analysis of the C. elegans sex-determining RT gene tra-1: A gene encoding two Zinc finger proteins RL Cell 70:237-249 (1992). XX // AC T00846 XX ID T00846 XX DT 15.10.92 (created); ewi. XX FA TREB-1 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX SZ 43, 37, 35 kDa XX CP (HeLa) XX BS R00359; AD$E4_13; Quality: 2; adenovirus type 5 BS R00360; AD$E4_14; Quality: 2; adenovirus type 5 BS R00362; AD$E4_16; Quality: 6; adenovirus type 5 BS R00471; HS$CFOS_14; Quality: 6; human, Homo sapiens BS R00777; HT1$HTLV1_01; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R00778; HT1$HTLV1_02; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I BS R00779; HT1$HTLV1_03; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I BS R00780; HT1$HTLV1_04; Quality: 6; HTLV-I, human T-cell lymphotropic virus type I XX RN [1] RA Tan T.-H., Horikoshi M., Roeder R. G. RT Purification and Characterization of Multiple Nuclear RT Factors That Bind to the TAX-Inducible Enhancer within RT the Human T-Cell Leukemia Virus Long Terminal Repeat RL Mol. Cell. Biol. 9:1733-1745 (1989). XX // AC T00847 XX ID T00847 XX DT 15.10.92 (created); ewi. XX FA TREB-2 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R00777; HT1$HTLV1_01; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I XX RN [1] RA Tan T.-H., Horikoshi M., Roeder R. G. RT Purification and Characterization of Multiple Nuclear RT Factors That Bind to the TAX-Inducible Enhancer within RT the Human T-Cell Leukemia Virus Long Terminal Repeat RL Mol. Cell. Biol. 9:1733-1745 (1989). XX // AC T00848 XX ID T00848 XX DT 15.10.92 (created); ewi. XX FA TREB-3 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CP (HeLa) XX BS R00777; HT1$HTLV1_01; Quality: 2; HTLV-I, human T-cell lymphotropic virus type I XX RN [1] RA Tan T.-H., Horikoshi M., Roeder R. G. RT Purification and Characterization of Multiple Nuclear RT Factors That Bind to the TAX-Inducible Enhancer within RT the Human T-Cell Leukemia Virus Long Terminal Repeat RL Mol. Cell. Biol. 9:1733-1745 (1989). XX // AC T00849 XX ID T00849 XX DT 14.04.93 (created); ewi. DT 16.05.97 (updated); hiwi. XX FA TRF XX SY TBP-related factor; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX SZ 224 AA; 25.5 kDa (cDNA), 27 kDa (SDS) XX SQ MQFHFKVADAERDRDNVAATSNAAANPHAALQPQQPVALVEPKDAQHEIRLQNIVATFSV SQ NCELDLKAINSRTRNSEYSPKRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEADIGS SQ RKFARILQKLGFPVKFMEYKLQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYR SQ MVKPRIVLLIFVNGKVVFTGAKSRKDIMDCLEAISPILLSFRKT XX SC translated from EMBL #X70837 XX FT 166 195 80-90% identity in the sigma-homology region FT 52 111 direct repeat I FT 142 202 direct repeat II XX SF C-terminal 174 AA: 60% identity to TBP XX CP medial dorsal region of the embryonic central nervous CP system; primary spermatocytes of adults XX FF TBP-like DNA-binding XX BS R01001; AD$MLP_16; Quality: 6; adenovirus XX DR EMBL: X70837; DMTRF(r). DR EMBL: X70838; DMTRFG(g). DR Flybase: FBgn0010287; Trf. XX RN [1] RA Crowley T. E., Hoey T., Liu J.-K., Jan Y. N., Jan L. Y., Tjian R. RT A new factor related to TATA-binding protein has highly RT restricted expression patterns in Drosophila RL Nature 361:557-561 (1993). XX // AC T00850 XX ID T00850 XX DT 07.11.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Ttx XX SY Trithorax; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0004; CC; 2.2.2.0.1. XX SZ 3759 AA; 404 kDa (cDNA) XX SQ MGRSKFPGKPSKSINRKRISVLQLEDDAANPAEPQQPAPESQQPSGSGSGSSAAREKGNN SQ CDNDEDDNAPGGASISGNTASSSAGSGNSGNGSSSGSSTGSGSSGSGSTNGGSVNGGTHH SQ KSAANLDKEAVTKDQNGDGDKTRGNVSSAPSGKLSAAASGKALSKSSRTFSASTSVTSSG SQ RSSGSSPDGNSGASSDGASSGISCGKSTAKSTEASSGKLAKTTGAGTCSSAKSSKASSLE SQ QLVKQQPLVSGACLKALFVATPATSTGLACALVSPGGSSQGGTFPISAALLRARKNSNKK SQ FKKLNLARGEVMLPSTSKLKQLNSPVVDNPSPSPPILSGSTPSVEGGIGVGGVVSPGEDA SQ ALKRVLTEMPNEVARDPSPSSCTAAANGAASGKGSASNGPPAMASSGDGSSPKSGADTGP SQ STSSTTAKQKKTVTFRNVLETSDDKSVVKRFYNPDIRIPIVSIMKKDSLNRPLNYSRGGE SQ CIVRPSILSKILNKNSNIDKLNSLKFRSAGASSSSSNQESRSSSNVFGLSRAFGAPMDED SQ DEGGVTFRRNDSPEDQNNAEDDEMDDDDDDEEAEEDDQNEDDNDEAASEKSAETEKSAGA SQ DERDPDEKQLVMDSHFVLPKRSTRSSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNVFGT SQ SSSSAGSTASTFSASTNLKLGKETFFNFGTLKPNSSAAGIFVLRQPRLQFQADNQQATFA SQ APKACPTSPSAIPKPANSLATSSFGSLASTNSSTVTPTPSACSICSAVVSSKEVTQARKY SQ GVVACDVCRKFFSKMTKKSISANSSTANTSSGSQQYLQCKGNEGSPCSIHSAKSQLKNFK SQ KFYKDRCTACWLKKCMISFQLPAAHRSRLSAILPPGMRGEAAAREEKSAELLSPTGSLRF SQ TSTASSSSPSVVASTSVKWKSSGDSTSALTSIKPNPLAENNVTFGSTPLLRPAILENPLF SQ LKISNAADQKLAAAEAISPSLTKKNSKQEKEKVKESEQSEKLLSPTQAGTKKSGAAEAQV SQ EEVQPQKEEAPQTSTTTQPSASNGASHGVPQAELAGETNATGDTLKRQRIDLPGPRVKHV SQ CRSASIVLGQPLATFGEDQQPEDAADMQQEIAAPVPSAIMEPSPEKPTHIVTDENDNCAS SQ CKTSPVGDESKPSKSSGSAQAEVKKATALGKEGTASAAGGSSAKVTTRNAAVASNLIVAA SQ SKKQRNGDIATSSSVTQSSNQTQGRKTKEHRQQRTLISIDFWENYDPAEVCQTGFGLIVT SQ ETVAQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTV SQ NASTGPSSSLNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLG SQ ADRPLICVNCLKCKSCSTTKVSKFVGNLPMCTGCFKLRKKGNFCPICQRCYDDNDFDLKM SQ MECGDCGQWVHSKCEGLSDEQYNLLSTLPESIEFICKKCARRNESSKIKAEEWRQAVMEE SQ FKASLYSVLKLLSKSRQACALLKLSPRKNVRCTCGASSNQGKLQPKALQFSSGSDNGLGS SQ DGESQNSDDVYEFKDQQQQQQQRNANMNKPRVKPLPCSCQQHISHSQSFSLVDIKQKIAG SQ NSYVSLEEFNYDMSQVIQQSNCDELDIAYKELLSEQFPWFQNETKACTDALEEDMFESCS SQ GGNYEDLQDAGGVSASVYNEHSTSQAESRSGVLDIPLEEVDDFGSCGIKMRLDTRMCLFC SQ RKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVC SQ GNRGATVGCNVRSCGEHYHYPCARSIDCAFLTDKSMYCPAHAKNGNALKANGSPSVTYES SQ NFEVSRPVYVELDRKRKKLIEPARVQFHIGSLEVRQLGAIVPRFSDSYEAVVPINFLCSR SQ LYWSSKEPWKIVEYTVRTTIQNSSSTLTALDVGRNYTVDHTNPNSKEVQLGMAQIARWHT SQ SLARSEFLENGGTDWSGEFPNPNSCVPPDQNTEEEPQQQADLLPPWLTSPLKFLGLSTHG SQ GLLLWLLLGVVVRLKQGGELKDAIFEDLPHELLDGISMLDIFLYDDKTDLFAISEQSKDG SQ TQAMTSNQAQNQNQQAGGANSVSICDEDTRNSNTSLGNGWPASNPVEDAMLSAARNSSQV SQ QMLKTLAWPKLDGNSAMATAIKRRKLSKNLAEGVFLTLSSQQRNKKEMATVAGVSRRQSI SQ SETSVEGVATTSGSVRSKSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIIS SQ GDGNLSTAQFSGQVKCDRCQCTYRNYDAFQRHLPSCSPTMSSNETESDVSGQGMTNNATQ SQ ISAESLNELQKQLLANAGGLNCLQSATSFPQVQSLGSLGQFGLQGLQQLQLQPQSLGDGF SQ FLSQPDPATQADTDDLQIYANSLQSLAANLGGGFTLAQPTVTAPAQPQLIAVSTNPDGTQ SQ QFIQIPQTMQATTTPTATYQTLQATNTDKKIMLPLTAAGKPLKTVATKAAQQAAVKQRQL SQ KSGHQVKPIQAKLQPHPQQHQQQQQTQVQQPITVMGQNLLQPQLLFQSSTQTQAPQIILP SQ QAQPQNIISFVTGDGSQGQPLQYISIPTAGEYKPQPQPTATPTFLTTAPGAGATYLQTDA SQ SGNLVLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQPGSNQQPLILG SQ GTGGGSSGLEFATTSPQVILATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLSQNASFSA SQ TTTQVFQASKIEPIVDLPAGYVVLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNAN SQ FQFQSVPTSSGASTSMDYTSPVMVTAKIPPVTQIKRTNAQAKAAGISGVGKVPPQPQVVN SQ KVLPTSIVTQQSQVQVKNSNLKQSQVKGKAASGTGTTCGAPPSIASKPLQKKTNMIRPIH SQ KLEVKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQ SQ QQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELANR SQ VQHFSTSSSSSSSNCSLPTNVVNPMQQQAPSTTSSSTTRPTNRVLPMQQRQEPAPLSNEC SQ PVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPVYEAELKVSSVLESIVPDVTMD SQ AILEEQPVTQSIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLDKHTFQVE SQ PMDTDVYREEDLEEEEDEDDDFSLKMRTSACNDHEMSDSEEPAVKDKISKILDNLTNDDC SQ ADSIATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALETAAVEAAATYINEMAD SQ AHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQPIQEPKKMTGP SQ HLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKT SQ NALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHG SQ LLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRR SQ GTGSNLPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLT SQ DKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIII SQ FAVRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN XX SC SwissProt #P20659 XX SF 9 putative zinc finger motifs, partially with histidines SF glutamine-rich region, serine-/threonine-rich region, acidic region XX FF activator of Ubx XX DR EMBL: M31617; DMZBPA(r). DR SwissProt: P20659; TRX_DROME. DR Flybase: FBgn0003862; trx. XX RN [1] RA Mazo A. M., Huang D.-H., Mozer B. A., Dawid I. B. RT The trithorax gene, a trans-acting regulator of the RT bithorax complex in Drosophila, encodes a protein with zinc-binding domains RL Proc. Natl. Acad. Sci. USA 87:2112-2116 (1990). XX // AC T00851 XX ID T00851 XX DT 15.10.92 (created); ewi. DT 22.02.96 (updated); ewi. XX FA T3R-beta XX SY thyroid hormone receptor-beta; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); . XX SZ 456 AA; 52.2 kDa (cDNA) XX FT 120 124 P-box FT 181 192 A-box of region D, determines the FT arrangement of DBD-dimerization interface FT 230 456 C-terminal dimerization interface XX SF DNA-binding domain: approx. 180 deg rotated with resp. SF to dimerization interface (in contrast to RXR and steroid receptors) SF DNA-binding domain, 1st zinc finger (DR-box): heterodimerization SF with RXR-alpha = determinant of half-site spacing SF favoring 4bp in direct repeats SF P-box determines DNA-binding specificity for different SF everted repeat binding sites (type ER6) [8] and their SF flanking sequences [9]; XX FF dominant negative mutants causing thyroid hormone FF resistance syndrome: G340R, P448H, delta448-456 (as FF in v-ErbA) bind to TRE but do not mediate positive or negative T3 response; FF DNA-binding is antagonized by AP-1, dependent on the FF C-terminal 17 amino acid residues; FF the particular structure of the DBD leads to preferential FF binding of heterodimers to direct repeats (downstream FF half-site), but of homodimers to palindromes; FF XX IN T01331; RXR-alpha; mouse, Mus musculus. IN T01345; RXR-alpha; human, Homo sapiens. IN T01349; RXR-beta; rat, Rattus norvegicus. IN T01355; TRAP; human, Homo sapiens. IN T01359; RXR-alpha; clawed frog, Xenopus laevis. XX BS R03564; AS$ER_03; Quality: 6 BS R03941; AS$RAR_03; Quality: 2 BS R01465; AS$TR_01; Quality: 1 BS R03565; AS$TR_03; Quality: 6 BS R03952; AS$TR_12; Quality: 2 BS R03953; AS$TR_13; Quality: 2 BS R03954; AS$TR_14; Quality: 2 BS R03980; AS$TR_15; Quality: 2 BS R03982; AS$TR_16; Quality: 2 BS R03983; AS$TR_17; Quality: 2 BS R03984; AS$TR_18; Quality: 2 BS R04404; AS$TR_19; Quality: 2 BS R03942; HS$CAMHC_01; Quality: 6; human, Homo sapiens BS R03960; HS$EGFR_23; Quality: 2; human, Homo sapiens BS R03958; HS$GHA_11; Quality: 6; human, Homo sapiens BS R03102; HS$TSHB_03; Quality: 6; human, Homo sapiens BS R02595; MOMLV$MOMULV_19; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R01169; RAT$AMHC_02; Quality: 1; rat, Rattus norvegicus BS R00618; RAT$GRH_12; Quality: 2; rat, Rattus norvegicus BS R01617; RAT$ME_01; Quality: 1; rat, Rattus norvegicus BS R03523; TR$CONS_02; Quality: 6 BS R01906; XENLA$VITA2_02; Quality: 6; clawed frog, Xenopus laevis XX DR EMBL: X04707; HSERBAR(r). DR SwissProt: P10828; THB1_HUMAN. DR SwissProt: P37243; THB2_HUMAN. XX RN [1] RA Zhang X. K., Hoffmann B., Tran P. B.-V., Graupner G., Pfahl M. RT Retinoid X receptor is an auxiliary protein for thyroid RT hormone and retinoic acid receptors RL Nature 355:441-446 (1992). RN [2] RA Kliewer S. A., Umesono K., Mangelsdorf D. J., Evans R. M. RT Retinoid X receptor interacts with nuclear receptors RT in retinoic acid, thyroid hormone and vitamin D3 signalling RL Nature 355:446-449 (1992). RN [3] RA Krishna V., Chatterjee K., Nagaya T., Madison L. D., RA Datta S., Rentoumis A., Jameson J. L. RT Thyroid hormone resistance syndrome: inhibition of RT normal receptor function by mutant thyroid hormone receptors RL J. Clin. Invest. 87:1977-1984 (1991). RN [4] RA Zhang X.-K., Wills K. N., Husman M., Hermann T., Pfahl M. RT Novel pathway for thyroid hormone receptor action RT through interaction with jun and fos oncogene activities RL Mol. Cell. Biol. 11:6016-6025 (1991). RN [5] RA Kurokawa R., Yu V. C., Naeaer A., Kyakumoto S., Han RA Z., Silverman S., Rosenfeld M. G., Glass C. K. RT Differential orientations of the DNA-binding domain RT and carboxy-terminal dimerization interface regulate RT binding site selection by nuclear receptor heterodimers RL Genes Dev. 7:1423-1435 (1993). RN [6] RA Perlman T., Rangarajan P. N., Umesono K., Evans R. M. RT Determinants for selective RAR and TR recognition of direct repeat HREs RL Genes Dev. 7:1411-1422 (1993). RN [7] RA Petty K. J., Desvergne B., Mitsuhashi T., Nikodem V. M. RT Identification of a thyroid hormone response element RT in the malic enzyme gene RL J. Biol. Chem. 265:7395-7400 (1990). RN [8] RA Nelson C. C., Hendy S. C., Romaniuk P. J. RT Relationship between P-box acid sequence and DNA binding RT specificity of the thyroid hormone receptor. The effects RT of half-site sequence in everted repeats RL J. Biol. Chem. 270:16981-16987 (1995). RN [9] RA Nelson C. C., Hendy S. C., Romaniuk P. J. RT Relationship between P-box acid sequence and DNA binding RT specificity of the thyroid hormone receptor. The effects RT of sequences flanking half-sites in thyroid hormone response elements RL J. Biol. Chem. 270:16988-16994 (1995). XX // AC T00852 XX ID T00852 XX DT 14.12.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA T3R-beta XX SY betac-ErbA; c-ErbA-beta; thyroid hormone receptor-beta; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); . XX SF splice variants T3R-beta1 and T3R-beta2 XX FF T3-binding with KD = 0.4 nM (beta1) XX IN T01345; RXR-alpha; human, Homo sapiens. IN T01349; RXR-beta; rat, Rattus norvegicus. IN T01355; TRAP; human, Homo sapiens. XX BS R01465; AS$TR_01; Quality: 6 BS R02714; HS$AMHC_02; Quality: 6; human, Homo sapiens BS R03959; RAT$GRH_23; Quality: 2; rat, Rattus norvegicus BS R03523; TR$CONS_02; Quality: 6 XX DR EMBL: J03933; RNCERBAB(r). XX RN [1] RA Flink I. L., Morkin E. RT Interaction of Thyroid Hormone Receptors with Strong RT and Weak cis-Acting Elements in the Human alpha-Myosin RT Heavy Chain Gene Promoter RL J. Biol. Chem. 265:11233-11237 (1990). RN [2] RA Koenig R. J., Warne R. L., Brent G. A., Harney J. RA W., Larsen P. R., Moore D. D. RT Isolation of a cDNA clone encoding a biologically RT active thyroid hormone receptor RL Proc. Natl. Acad. Sci. USA 85:5031-5035 (1988). RN [3] RA Murray M. B., Zilz N. D., McCreary N. L., MacDonald M. J., Towle H. C. RT Isolation and characterization of rat cDNA clones RT for two distinct thyroid hormone receptors RL J. Biol. Chem. 263:12770-12777 (1988). XX // AC T00853 XX ID T00853 XX DT 14.12.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA T3R-beta1 XX SY thyroid hormone receptor-beta1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); . XX SZ 461 AA; 52.7 kDa (cDNA) XX SQ MTPNSMTENRLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQ SQ ATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR SQ CITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVL SQ DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK SQ QKRKFLPEDIGQAPIVNAPEGGQVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED SQ QIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL SQ SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK SQ LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED XX SC SwissProt #P18113 XX FT 286 305 contact to TRAP and RXR-beta XX SF splice variant: T3R-beta2 XX CP anterior pituitary gland, parvocellular part of the CP paraventriculuar hypothalamic nucleus XX FF mediating thyroid hormone feedback regulation of thyroid-stimulating FF hormone and thyrotropin-releasing hormone XX IN T01332; RXR-beta; mouse, Mus musculus. IN T01334; RXR-beta; human, Homo sapiens. IN T01349; RXR-beta; rat, Rattus norvegicus. IN T01355; TRAP; human, Homo sapiens. XX BS R01465; AS$TR_01; Quality: 1 BS R03942; HS$CAMHC_01; Quality: 6; human, Homo sapiens BS R03102; HS$TSHB_03; Quality: 6; human, Homo sapiens BS R02595; MOMLV$MOMULV_19; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R03886; MOUSE$MBP_06; Quality: 2; mouse, Mus musculus BS R04401; MOUSE$PCP2_01; Quality: 1; rat, Rattus norvegicus BS R04402; MOUSE$PCP2_02; Quality: 1; rat, Rattus norvegicus BS R00619; RAT$GRH_13; Quality: 1; rat, Rattus norvegicus BS R01617; RAT$ME_01; Quality: 2; rat, Rattus norvegicus BS R02694; RAT$S14_03; Quality: 1; rat, Rattus norvegicus BS R02695; RAT$S14_04; Quality: 1; rat, Rattus norvegicus BS R02696; RAT$S14_05; Quality: 1; rat, Rattus norvegicus BS R03523; TR$CONS_02; Quality: 6 XX DR EMBL: J03933; RNCERBAB(r). DR SwissProt: P18113; THB1_RAT. XX RN [1] RA Rosen E. D., Beninghof E. G., Koenig R. J. RT Dimerization interfaces of thyroid hormone, retinoic RT acid, vitamin D, and retinoid X receptors RL J. Biol. Chem. 268:11534-11541 (1993). RN [2] RA Selmi S., Samuels H. H. RT Thyroid hormone receptor / and v-erbA: a single amino RT acid difference in the C-terminal region influences RT dominant negative activity and receptor dimer formation RL J. Biol. Chem. 266:11589-11593 (1991). RN [3] RA Zilz N. D., Murray M. B., Towle H. C. RT Identification of Multiple Thyroid Hormone Response RT Elements Located Far Upstream from the Rat S14 Promoter RL J. Biol. Chem. 265:8136-8143 (1990). RN [4] RA Koenig R. J., Warne R. L., Brent G. A., Harney J. RA W., Larsen P. R., Moore D. D. RT Isolation of a cDNA clone encoding a biologically RT active thyroid hormone receptor RL Proc. Natl. Acad. Sci. USA 85:5031-5035 (1988). RN [5] RA Murray M. B., Zilz N. D., McCreary N. L., MacDonald M. J., Towle H. C. RT Isolation and characterization of rat cDNA clones RT for two distinct thyroid hormone receptors RL J. Biol. Chem. 263:12770-12777 (1988). XX // AC T00854 XX ID T00854 XX DT 28.01.93 (created); hse. DT 10.01.96 (updated); hiwi. XX FA T3R XX SY c-ErbA; thyroid hormone receptor; XX OS monkey, Cercopithecus aethiops OC eukaryota; animalia; metazoa; chordata; vertebrata; OC mammalia; theria; eutheria; primates; haplorhini; OC catarrhini; cercopithecidae; cercopithecinae XX CL C0002; CC (rec); . XX SZ 46 kDa (SDS) XX SF phosphorylation XX FF member of the steroid hormone receptor superfamily XX IN T00716; RAR; monkey, Cercopithecus aethiops. IN T00717; RAR; mouse, Mus musculus. IN T00718; RAR; cat, Felis catus. IN T00719; RAR-alpha1; human, Homo sapiens. IN T00720; RAR-gamma; human, Homo sapiens. XX BS R03523; TR$CONS_02; Quality: 6 XX RN [1] RA Baniahmad A., Steiner C., Koehne A. C., Renkawitz R. RT Modular structure of a chicken lysozyme silencer: RT involvement of an unusual thyroid hormone receptor binding site RL Cell 61:505-514 (1990). RN [2] RA Lazar M. A., Berrodin T. J., Harding H. P. RT Differential DNA binding by monomeric, homodimeric, RT and potentially heteromeric forms of the thyroid hormone receptor RL Mol. Cell. Biol. 11:5005-5015 (1991). XX // AC T00855 XX ID T00855 XX DT 15.10.92 (created); ewi. XX FA TSAP XX SY BSAP (human); XX OS sea urchin OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida XX SZ 85, 76 kDa XX BS R01665; SU$H2A21_01; Quality: 6; sea urchin BS R01668; SU$H2A22_02; Quality: 6; sea urchin BS R01661; SU$H2B21_01; Quality: 6; sea urchin BS R01664; SU$H2B22_02; Quality: 6; sea urchin XX RN [1] RA Barberis A., Widenhorn K., Vitelli L., Busslinger M. RT A novel B-cell lineage-specific transcription factor RT present at early but not late stages of differentiation RL Genes Dev. 4:849-859 (1990). XX // AC T00856 XX ID T00856 XX DT 15.10.92 (created); ewi. DT 29.01.97 (updated); ewi. XX FA TTF-1 XX SY T/EBP; thyroid nuclear factor 1; thyroid transcription factor 1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO NK-2 (Drosophila) XX CL C0006; homeo; 3.1.1.15.8. XX SZ 372 AA; 38.6 kDa (cDNA) XX SQ MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGH SQ HGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDP SQ RFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRF SQ KQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGG SQ GGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQQQAQAAQA SQ AAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGA SQ MSCSTLLYGRTW XX SC SwissProt #P23441 XX FT 161 220 homeo domain FT 234 244 glycine-rich region (10/11) FT 247 254 glutamine-rich region (7/8) FT 287 304 glutamine-/alanine-rich region (18/18) XX SF homeo domain is most closely related to that of NK-2 (82% identity) [10]; SF DNA-binding specificity is determined by the recognition SF helix plus additional parts of the HD [4]; SF essential for TTF-1 binding to CAAG instead of TAAT SF as most other HD factors is Gln-210 [7]; SF three-dimensional models of the TTF-1 HD suggest the SF presence of 4 alpha-helices, helix 3 and 4 immediately abutting [6]; XX CP thyroid, lung [10]; CN brain, heart, intestine, kidney, liver, muscle, pituitary, CN spleen, stomach, testis, thymus [10]; XX FF required for thyroid-specific gene expression [10]; FF DNA-binding capability may be regulated through oxidation FF of Cys-87 and Cys-363 [2]; FF expressed at the earliest stages of differentiation FF of thyroid and lung tissue [5]; FF in the lung, it is confined to bronchial epithelium at later stages; FF expression occurs also in some restricted areas in FF the fetal brain (e. g., hypothalamic area of diencephalon, FF infundibulum, telencephalon at day 10.5 p.c.) [5]; FF may be a specific target of HOXB3 [8]; XX BS R02471; HS$TPO_02; Quality: 6; human, Homo sapiens BS R01879; RAT$TG_06; Quality: 6; rat, Rattus norvegicus BS R01880; RAT$TG_07; Quality: 6; rat, Rattus norvegicus BS R01882; RAT$TG_09; Quality: 3; rat, Rattus norvegicus BS R04318; RAT$TPO_01; Quality: 5; rat, Rattus norvegicus BS R04319; RAT$TPO_02; Quality: 5; rat, Rattus norvegicus BS R04320; RAT$TPO_03; Quality: 5; rat, Rattus norvegicus BS R04322; RAT$TPO_05; Quality: 5; rat, Rattus norvegicus BS R02257; TTF1$CONS; Quality: 6 XX DR EMBL: X53858; RNTTF1(r). DR SwissProt: P23441; TTF1_RAT. DR PIR: S12002; S12002. DR PDB: 1ftt; THYROID TRANSCRIPTION FACTOR 1 HOMEODOMAIN RATTUS NORVEGICUS. XX RN [1] RA Viglino P., Fogolari F., Formisiano S., Bortolotti RA N., Damante G., Di Lauro R., Esposito G. RT Structural study of rat thyroid transcription factor RT 1 homeodomain (TTF-1 HD) by nuclear magnetic resonance RL FEBS Lett. 336:397-402 (1993). RN [2] RA Arnone M. I., Zannini M., Di Lauro R. RT The DNA binding actvity and the dimerization ability RT of the thyroid transcription factor I are redox regulated RL J. Biol. Chem. 270:12048-12055 (1995). RN [3] RA Van Renterghem P. H. G., Dremier S., Vassar G., Christophe J. RT Study of TTF1 gene expression in dog thyrocytes in primary culture RL Mol. Cell. Endocrinology 112:83-93 (1995). RN [4] RA Damante G., Di Lauro R. RT Several regions of Antennapedia and thyroid transcription RT factor 1 homeodomains contribute to DNA binding specificity RL Proc. Natl. Acad. Sci. USA 88:5388-5392 (1991). RN [5] RA Lazzaro D., Price M., De Felice M., Di Lauro R. RT The transcription factor TTF-1 is expressed at the RT onset of thyroid and lung morphogenesis and in restricted RT regions of the foetal brain RL Development 113:1093-1104 (1991). RN [6] RA Fogolari F., Esposito F., Viglino P., Damante G., Pastore A. RT Homology model building of the thyroid transcription factor 1 homeodoamin RL Protein Engineering 6:513-519 (1993). RN [7] RA Damante G., Fabbro D., Pellizzari L., Civitareale RA D., Guazzi S., Polycarpou-Schwartz M., Cauci S., Quadrifoglio RA F., Formisano S., Di Lauro R. RT Sequence-specific DNA recognition by the thyroid transcription RT factor-1 homeodomain RL Nucleic Acids Res. 22:3075-3083 (1994). RN [8] RA Guazzi S., Lonigro R., Pintonello L., Boncinelli E., Di Lauro R., Mavilio F. RT The thyroid transcription factor-1 gene is a candidate RT target for regulation by Hox proteins RL EMBO J. 13:3339-3347 (1994). RN [9] RA Civitareale D., Lonigro R., Sinclair A. J., Di Lauro R. RT A thyroid-specific nuclear protein essential for tissue-specific RT expression of the thyroglobulin promoter RL EMBO J. 8:2537-2542 (1989). RN [10] RA Guazzi S., Price M., De Felice M., Damante G., Mattei M., Di Lauro R. RT Thyroid nuclear factor 1 (TTF-1) contains a homeodomain RT and displays a novel DNA binding specificity RL EMBO J. 9:3631-3639 (1990). RN [11] RA Avvedimento V. E., Musti A. M., Ueffing M., Obici RA S., Gallo A., Sanchez M., DeBrasi D., Gottesman M. E. RT Reversible inhibition of a thyroid-specific trans-acting factor by Ras RL Genes Dev. 5:22-28 (1991). RN [12] RA Mizuno K., Gonzales F. J., Kimura S. RT Thyroid-specific enhancer-binding protein (T/EBP): RT cDNA cloning, functional characterization, and structural RT identity with thyroid transcription factor TTF-1 RL Mol. Cell. Biol. 11:4927-4993 (1991). XX // AC T00857 XX ID T00857 XX DT 28.01.93 (created); hse. DT 29.01.97 (updated); ewi. XX FA TTF-1 XX SY thyroid nuclear factor 1; thyroid transcription factor 1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO NK-2 (Drosophila) XX CL C0006; homeo; 3.1.1.15.8. XX SZ 371 AA; 38.6 kDa (cDNA) XX SQ MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGH SQ HGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDP SQ RFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRF SQ KQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGG SQ GTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAA SQ AAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTM SQ SCSTLLYGRTW XX SC SwissProt #P43699 XX FT 234 243 glycine-rich region (9/10) FT 246 253 glutamine-rich region (7/8) FT 286 303 glutamine-/alanine-rich region (17/18) FT 161 220 homeo domain XX BS R02257; TTF1$CONS; Quality: 6 XX DR EMBL: X82850; HSTTF1(r). DR SwissProt: P43699; TTF1_HUMAN. XX RN [1] RA Saiardi A., Tassi V., De Filippis V., Civitareale D. RT Cloning and sequence analysis of human thyroid transcription factor 1 RL Biochim. Biophys. Acta 1261:307-310 (1995). RN [2] RA Oguchi H., Pan Y. T., Kimura S. RT The complete nucleotide sequence of the mouse thyroid-specific RT enhancer-binding protein (T/EBP) gene: extensive identity RT of the deduced amino acid sequence with the human protein RL Biochim. Biophys. Acta 1261:304-306 (1995). RN [3] RA Ikeda K., Clark J. C., Shaw-White J. R., Stahlman RA M. T., Boutell C. J., Whitsett J. A. RT Gene structure and expression of human TTF-1 in respiratory epithelial cells RL J. Biol. Chem. 270:8108-8114 (1995). XX // AC T00858 XX ID T00858 XX DT 28.01.93 (created); hse. XX FA TTF-1 XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0006; homeo; 3.1.1.15.8. XX SZ 38 kDa XX CP thyroid cells, lung XX BS R02257; TTF1$CONS; Quality: 6 XX RN [1] RA Guazzi S., Price M., De Felice M., Damante G., Mattei M., Di Lauro R. RT Thyroid nuclear factor 1 (TTF-1) contains a homeodomain RT and displays a novel DNA binding specificity RL EMBO J. 9:3631-3639 (1990). RN [2] RA Avvedimento V. E., Musti A. M., Ueffing M., Obici RA S., Gallo A., Sanchez M., DeBrasi D., Gottesman M. E. RT Reversible inhibition of a thyroid-specific trans-acting factor by Ras RL Genes Dev. 5:22-28 (1991). RN [3] RA Mizuno K., Gonzales F. J., Kimura S. RT Thyroid-specific enhancer-binding protein (T/EBP): RT cDNA cloning, functional characterization, and structural RT identity with thyroid transcription factor TTF-1 RL Mol. Cell. Biol. 11:4927-4993 (1991). XX // AC T00859 XX ID T00859 XX DT 28.01.93 (created); hse. XX FA TTF-1 XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0006; homeo; 3.1.1.15.8. XX SZ 38 kDa XX CP thyroid cells, lung XX BS R02257; TTF1$CONS; Quality: 6 XX RN [1] RA Guazzi S., Price M., De Felice M., Damante G., Mattei M., Di Lauro R. RT Thyroid nuclear factor 1 (TTF-1) contains a homeodomain RT and displays a novel DNA binding specificity RL EMBO J. 9:3631-3639 (1990). RN [2] RA Avvedimento V. E., Musti A. M., Ueffing M., Obici RA S., Gallo A., Sanchez M., DeBrasi D., Gottesman M. E. RT Reversible inhibition of a thyroid-specific trans-acting factor by Ras RL Genes Dev. 5:22-28 (1991). RN [3] RA Mizuno K., Gonzales F. J., Kimura S. RT Thyroid-specific enhancer-binding protein (T/EBP): RT cDNA cloning, functional characterization, and structural RT identity with thyroid transcription factor TTF-1 RL Mol. Cell. Biol. 11:4927-4993 (1991). XX // AC T00860 XX ID T00860 XX DT 15.10.92 (created); ewi. XX FA TUBF XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01760; HS$AAC_19; Quality: 6; human, Homo sapiens XX RN [1] RA Gustafson T. A., Kedes L. RT Identification of Multiple Proteins That Interact RT with Functional Regions of the Human Cardiac alpha-Actin Promoter RL Mol. Cell. Biol. 9:3269-3283 (1989). XX // AC T00861 XX ID T00861 XX DT 15.10.92 (created); ewi. XX FA TyBF XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX BS R03756; Y$HIS4_15; Quality: 6; yeast, Saccharomyces cerevisiae BS R01478; Y$TY917_01; Quality: 6; yeast, Saccharomyces cerevisiae XX RN [1] RA Goel A., Pearlman R. E. RT Transposable Element-Mediated Enhancement of Gene RT Expression in Saccharomyces cerevisiae Involves Sequence-Specific RT Binding of a trans-Acting Factor RL Mol. Cell. Biol. 8:2572-2580 (1988). XX // AC T00862 XX ID T00862 XX DT 15.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA UBP-1 XX SY LBP-1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX HO TAR-binding factor XX SZ 63 kDa XX BS R00706; HIV1$HIV1_13; Quality: 6; HIV-1, human immunodeficiency virus type 1 BS R02258; UBP1$CONS; Quality: 6 XX RN [1] RA Wu F. K., Garcia J. A., Harrich D., Gaynor R. B. RT Purification of the human immunodeficiency virus type RT 1 enhancer and TAR binding proteins EBP-1 and UBP-1 RL EMBO J. 7:2117-2129 (1988). XX // AC T00863 XX ID T00863 XX DT 15.10.92 (created); ewi. DT 29.01.97 (updated); ewi. XX FA Ubx XX SY Ultrabithorax; XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; OC diptera; drosophiloidea; drosophilidae XX CL C0006; homeo; 3.1.1.2.32. XX SZ 389 AA; 40.0 kDa (gene) XX SQ MNSYFEQASGFYGHPHQATGMAMGSGGHHDQTASAAAAAYRGFPLSLGMSPYANHHLQRT SQ TQDSPYDASITAACNKIYGDGAGAYKQDCLNIKADAVNGYKDIWNTGGSNGGGGGGGGGG SQ GGGAGGTGGAGNANGGNAANANGQNNPAGGMPVRPSACTPDSRVGGYLDTSGGSPVSHRG SQ GSAGGNVSVSGGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTFY SQ PWMAIAGECPEDPTKSKIRSDLTQYGGISTDMGKRYSESLAGSLLPDWLGTNGLRRRGRQ SQ TYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKEL SQ NEQEKQAQAQKAAAAAAAAAAVQGGHLDQ XX SC SwissProt #P02834 XX FT 107 136 glycine-rich region (22/30) FT 248 256 missing in some splice variants FT 257 273 encoded by -30kb microexon, missing FT in class II and IV variants FT 274 290 encoded by -40kb microexon, missing in class IV variants FT 367 381 alanine-rich region (12/15) FT 295 354 homeo domain XX SF several splice variants, differing in sequences encoded SF by some microexons [16], [9]; SF binds to DNA through the homeo domain [12]; SF cooperation with other factors is required for repression [12]; SF cooperative binding to DNA with Exd [4], [8]; SF essential for Exd interaction are residues 23, 25, SF 57, which also discriminate between Ubx and Antp functions SF [6], and the C-terminus [8], [6]; SF discriminator residues (over Dfd [17], [3] and Abd-B [2]; SF KD = 0.7 pM for binding to an optimal DNA sequence SF (TTAATGG, with the central TAAT being of particular importance) [18]; XX FF activator [11], [21] and repressor [11], [13]; FF facilitates assembly of transcription initiation complex [7]; FF homeotic selector gene product required for proper FF development of thoracic structures; FF positive autoregulation through a cluster of downstream FF binding sites [11] or through indirect mechanisms FF as in the visceral mesoderm, probably involving wingless FF and decapentaplegic gene products [14], [5]; FF a far upstream enhancer activates Ubx expression in FF parasegments 6, 8, 10, and 12, and represses it in FF the anterior half of the embryo in a Hb-dependent manner [19]; FF the same enhancer is activated by Tll and Ftz [19], [10]; FF after Ubx induction, its expression pattern is maintained FF by trithorax group genes in expressing cells and by FF Polycomb group genes in non-expressing cells [15]; XX IN T01482; Exd; fruit fly, Drosophila melanogaster. XX MX M00018; I$UBX_01 XX BS R02477; AS$UBX_01; Quality: 6 BS R02478; AS$UBX_02; Quality: 6 BS R02479; AS$UBX_03; Quality: 6 BS R02508; AS$UBX_04; Quality: 6 BS R02509; DROME$DPP_01; Quality: 2; fruit fly, Drosophila melanogaster BS R01529; DROME$UBX_14; Quality: 6; fruit fly, Drosophila melanogaster BS R02480; UBX$CONS; Quality: 6 XX DR EMBL: K01959; DMHOMUBX(g). DR EMBL: K01963; DMUBX(g). DR EMBL: X05727; DMUBX5(g). DR SwissProt: P02834; HMUX_DROME. DR PIR: A03319; A03319. DR Flybase: FBgn0003944; Ubx. XX RN [1] RA Biggin M. D., Tjian R. RT Transcription factors that activate the Ultrabithorax RT promoter in developmentally staged extracts RL Cell 53:699-711 (1988). RN [2] RA Ekker S. C., Jackson D. G., von Kessler D. P., Sun RA B. I., Young K. E., Beachy P. A. RT The degree of variation in DNA sequence recognition RT among four Drosophila homeotic proteins RL EMBO J. 13:3551-3560 (1994). RN [3] RA Vachon G., Cohen B., Pfeifle C., McGuffin M. E., Botas J., Cohen S. M. RT Ho-meotic genes of the Bithorax complex repress limb RT development in the abdomen of the Drosophila embryo RT through the target gene Distal-less RL Cell 71:435-450 (1992). RN [4] RA Van Dijk M. A., Murre C. RT extradenticle raises the DNA binding specificity of RT homeotic selector gene products RL Cell 78:617-624 (1994). RN [5] RA Capovilla M., Brandt M., Botas J. RT Direct regulation of decapentaplegic by Ultrabithorax RT and its role in Drosophila midgut morphogenesis RL Cell 76:461-475 (1994). RN [6] RA Chan S.- K., Mann R. S. RT The segment identity functions of Ultrabithorax are RT contained within its homeodomain and carboxy-terminal seuqences RL Genes Dev. 7:796-811 (1993). RN [7] RA Johnson F. B., Krasnow M. A. RT Differential regulation of transcription preinitiation RT complex assembly by activator and repressor homeo domain protein RL Genes Dev. 6:2177-2189 (1992). RN [8] RA Chan S.-K., Jaffe L., Capovilla M., Botas J., Mann R. S. RT The DNA binding specificity of Ultrabithorax is modulated RT by cooperative interactions with Extradenticle, another homeoprotein RL Cell 78:603-615 (1994). RN [9] RA Weinzierl R., Axton J. M., Ghysen A., Akam M. E. RT Ultrabithorax mutations in constant and variable regions RT of the protein coding sequence RL Genes Dev. 1:386-397 (1987). RN [10] RA Quian S., Capovilla M., Pirotta V. RT Molecular mechanisms of pattern formation by the BRE RT enhancer of the Ubx gene RL EMBO J. 12:3865-3877 (1993). RN [11] RA Krasnow M. A., Saffman E. E., Kornfeld K., Hogness D. S. RT Transcriptional activation and repression by Ultrabithorax RT proteins in cultured Drosophila cells RL Cell 57:1031-1043 (1989). RN [12] RA Samson M.-L., Jackson-Grusby L., Brent R. RT Gene activation and DNA binding by Drosophila Ubx and abd-A proteins RL Cell 57:1045-152 (1989). RN [13] RA Graba Y., Aragnol D., p: Laurenti , Garzino V., Charmot RA D., Berenger H., Pradel J. RT Homeotic control in Drosophila: the scabrous gene RT is an in vivo target of Ultrabithorax proteins RL EMBO J. 11:3375-3384 (1992). RN [14] RA Thueringer F., Cohen S. M., Bienz M. RT Dissection of an indirect autoregulatory response RT of a homeotic Drosophila gene RL EMBO J. 12:2419-2430 (1993). RN [15] RA Chan C.-S., Rastelli L., Pirrotta V. RT A Polycomb response element in the Ubx gene that determines RT an epigenetically inherited state of expression RL EMBO J. 13:2553-2564 (1994). RN [16] RA Hogness D. S., Lipshitz H. D., Beachy P. A., Peattie RA D. A., Saint R. B., Goldschmidt-Clermont M., Harte RA P. J., Gavis E. R., Helfand S. L. RT Regulation and products of the Ubx domain of the bithorax complex RL Cold Spring Harbor Symp. Quant. Biol. 50:181-194 (1985). RN [17] RA Ekker S. C., von Kessler D. P., Beachy Ph. A. RT Differential DNA sequence recognition is a determinant RT of specificity in homeotic gene action RL EMBO J. 11:4059-4072 (1992). RN [18] RA Ekker S. C., Young K. E., von Kessler D. P., Beachy P. A. RT Optimal DNA sequence recognition by the Ultrabithorax RT homeodomain of Drosophila RL EMBO J. 10:1179-1186 (1991). RN [19] RA Qian S., Capovilla M., Pirrotta V. RT The bx region enhancer, a distant cis-control element RT of the Drosophila Ubx gene and its regulation by hunchback RT and other segmentation genes RL EMBO J. 10:1415-1425 (1991). RN [20] RA Lin L., McGinnis W. RT Mapping functional specificity in the Dfd and Ubx homeo domains RL Genes Dev. 6:1071-1081 (1992). RN [21] RA Johnson F. B., Krasnow M. A. RT Stimulation of transcription by an Ultrabithorax protein in vitro RL Genes Dev. 4:1044-1052 (1990). XX // AC T00864 XX ID T00864 XX DT 15.10.92 (created); ewi. DT 16.06.95 (updated); ewi. XX FA UCRF-L XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CP (spleen) XX BS R01148; MULV$MULV_01; Quality: 6; MuLV, murine leukemia virus XX RN [1] RA Flanagan J. R., Krieg A. M., Max E. E., Khan A. S. RT Negative Control Region at the 5' End of Murine Leukemia RT Virus Long Terminal Repeats RL Mol. Cell. Biol. 9:739-746 (1989). XX // AC T00865 XX ID T00865 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA UCRBP XX SY UCRF-U; YY1; upstream conserved region binding protein; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0001; CH; . XX SZ 414 AA; 44.7 kDa (cDNA) XX FT 43 53 acidic region (E5D4ED) FT 71 82 histidine-stretch (H12) FT 298 407 zinc finger motifs (4) XX SF GLI type zinc finger protein XX CP ubiquitous XX FF transcriptional repressor XX BS R01149; MULV$MULV_02; Quality: 2; MuLV, murine leukemia virus XX RN [1] RA Flanagan J. R., Krieg A. M., Max E. E., Khan A. S. RT Negative Control Region at the 5' End of Murine Leukemia RT Virus Long Terminal Repeats RL Mol. Cell. Biol. 9:739-746 (1989). RN [2] RA Flanagan J. R., Becker K. G., Ennist D. L., Gleason RA S. L., Driggers P. H., Levi B.-Z., Appella E., Ozato K. RT Cloning of a negative transcription factor that binds RT to the upstream conserved region of Moloney murine leukemia virus RL Mol. Cell. Biol. 12:38-44 (1992). XX // AC T00866 XX ID T00866 XX DT 15.10.92 (created); ewi. XX FA UFA XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX BS R01883; RAT$TG_10; Quality: 6; rat, Rattus norvegicus XX RN [1] RA Civitareale D., Lonigro R., Sinclair A. J., Di Lauro R. RT A thyroid-specific nuclear protein essential for tissue-specific RT expression of the thyroglobulin promoter RL EMBO J. 8:2537-2542 (1989). XX // AC T00867 XX ID T00867 XX DT 12.03.93 (created); ewi. XX FA UHF-1 XX OS sea urchin, Strongylocentrotus purpuratus OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida; strongylocentrotidae XX SZ 85 kDa (SDS) XX CP (hatching blastula) XX BS R02983; SP$EH4_01; Quality: 6; sea urchin, Strongylocentrotus purpuratus BS R02984; SP$LH4_01; Quality: 6; sea urchin, Strongylocentrotus purpuratus XX RN [1] RA Lee I. J., Tung L., Bumcrot D. A., Weinberg E. S. RT UHF-1, a factor required for maximal transcription RT of early and late sea urchin histone H4 genes: Analysis RT of promoter-binding sites RL Mol. Cell. Biol. 11:1048-1061 (1991). XX // AC T00868 XX ID T00868 XX DT 15.10.92 (created); ewi. DT 22.06.93 (updated); ewi. XX FA URSF XX SY URS-binding factor; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX SZ 40 kDa (SDS) XX FF binds simultaneously with HSF to SSA1 promoter, but FF is displaced by HSF upon heat shock XX BS R00772; Y$HSP70_02; Quality: 1; yeast, Saccharomyces cerevisiae XX RN [1] RA Park H.-O., Craig E. A. RT Positive and Negative Regulation of Basal Expression of a Yeast HSP70 Gene RL Mol. Cell. Biol. 9:2025-2033 (1989). RN [2] RA Park H.-O., Craig E. A. RT Transcriptional regulation of a yeast HSP70 gene by RT heat shock factor and an upstream repression site-binding factor RL Genes Dev. 5:1299-1308 (1991). XX // AC T00869 XX ID T00869 XX DT 26.10.92 (created); ewi. DT 14.05.94 (updated); ewi. XX FA URTF XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX HO CREB, AP-1 XX BS R02661; MOUSE$S11BH_01; Quality: 6; mouse, Mus musculus BS R02096; MOUSE$UPA_02; Quality: 6; mouse, Mus musculus XX RN [1] RA Rorth P., Nerlov C., Blasi F., Johnsen M. RT Transcription factor PEA3 participates in the induction RT of urokinase plasminogen activator transcription in RT murine keratinocytes stimulated with epidermal growth RT factor or phorbol-ester RL Nucleic Acids Res. 18:5009-5017 (1990). XX // AC T00870 XX ID T00870 XX DT 15.10.92 (created); ewi. XX FA USF XX SY MLTF; UEF; XX OS hamster OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; OC cricetidae; cricetinae; cricetini XX MX M00121; V$USF_01 MX M00122; V$USF_02 MX M00217; V$USF_C XX BS R00711; HA$HMGCR_04; Quality: 5; hamster BS R02259; USF$CONS; Quality: 6 XX RN [1] RA Osborne T. F., Gil G., Brown M. S., Kowal R. C., Goldstein J. L. RT Identification of promoter elements required for in RT vitro transcription of hamster 3-hydroxyl-3-methylglutaryl RT coenzyme A reductase gene RL Proc. Natl. Acad. Sci. USA 84:3614-3618 (1987). XX // AC T00871 XX ID T00871 XX DT 21.10.92 (created); ewi. DT 27.08.96 (updated); ewi. XX FA USF XX SY SpF1; XX OS sea urchin, Strongylocentrotus purpuratus OC eukaryota; animalia; metazoa; echinodermata; echinozoa; OC echinoidea; echinacea; echinoida; strongylocentrotidae XX CL C0010; bHLH; 1.3.1.2.1. XX SZ 265 AA; 29.1 kDa (cDNA) XX SQ MDVQDHTLDQGPQDKDKDLEEEVTVHLTADGDQVVQDPSGEGPFAENIQYQFRTDSNGQS SQ QVTYRVVQVGDNETNPQAVVTTFPQGHQALTQVIQGSFNGESPTSESQGGETRFTYFPAS SQ AAIPGDGAGPASGGEQQPGITQPSGAAGGQFYVMMSPQDVLQGASQRTIAPRTHQFNTKI SQ DNSRTVRDERRRATHNEVERRRRDKINNWIVKLSKIIPDCNIDHSKQGQSKGGILTKTCD SQ YIHDLRNSNTRMAKASRIRKGSPST XX SC translated from EMBL #S69017 XX FT 190 203 basic region FT 204 246 helix-loop-helix domain XX SF no leucine zipper! XX CP embryonic ectoderm XX BS R02080; SP$SPEC1_01; Quality: 3; sea urchin, Strongylocentrotus purpuratus XX DR EMBL: S69017; S69017(r). DR EMBL: S69019; S69019(r). XX RN [1] RA Kozlowski M. T., Gan L., Venuti J. M., Sawadogo M., Klein W. H. RT Sea urchin USF: A helix-loop-helix protein active RT in embryonic ectoderm cells RL Develop. Biol. 148:625-630 (1991). XX // AC T00872 XX ID T00872 XX DT 15.03.93 (created); ewi. XX FA USF XX SY gamma-factor; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX MX M00121; V$USF_01 MX M00122; V$USF_02 MX M00217; V$USF_C XX BS R01583; CHICK$VIT2_16; Quality: 4; chick, Gallus gallus BS R02259; USF$CONS; Quality: 6 XX RN [1] RA Seal S. N., Davis D. L., Burch J. B. E. RT Mutational studies reveal a complex set of positive RT and negative control elements within the chicken vitellogenin II promoter RL Mol. Cell. Biol. 11:2704-2717 (1991). XX // AC T00873 XX ID T00873 XX DT 15.10.92 (created); ewi. XX FA USF XX SY MLTF; MRF; UEF; yMRF; XX OS yeast, Saccharomyces cerevisiae OC eukaryota; plantae; thallobionta; eumycota; hemiascomycetes; OC endomycetales; saccharomycetaceae XX BS R02015; AD$IVA2_02; Quality: 2; adenovirus type 2 BS R00995; AD$MLP_10; Quality: 4; adenovirus BS R00442; RAT$GF_02; Quality: 2; rat, Rattus norvegicus XX RN [1] RA Chodosh L. A., Buratowski S., Sharp P. A. RT A Yeast Protein Possesses the DNA-Binding Properties RT of the Adenovirus Major Late Transcription Factor RL Mol. Cell. Biol. 9:820-822 (1989). RN [2] RA Moncollin V., Stalder R., Verdier J.-M., Sentenac A., Egly J.-M. RT A yeast homolog of the human UEF stimulates transcription RT from the adenovirus 2 major late promoter in yeast RT and in mammalian cell-free systems RL Nucleic Acids Res. 18:4817-4823 (1990). XX // AC T00874 XX ID T00874 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA USF XX SY MLTF; MRF (yeast); UEF; USF1; USF43; eUSF (duck); pf51; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0012; bHLH-ZIP; 1.3.1.2.2. XX SZ 310 AA; 33.5 kDa (cDNA), 43-55 kDa (SDS) XX SQ MKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPDPNVKYVFRTENGGQVM SQ YRVIQVSEGQLDGQTEGTGAISGYPATQSMTQAVIQGAFTSDDAVDTEGTAAETHYTYFP SQ STAVGDGAGGTTSGSTAAVVTTQGSEALLGQATPPGTGQFFVMMSPQEVLQGGSQRSIAP SQ RTHPYSPKSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSK SQ GGILSKACDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHG SQ LEVVIKNDSN XX SC SwissProt #P22415 XX FT 15 59 transcription activation domain FT 74 116 repeat TEGTxAxS/TxY) FT 93 156 transcription activation domain FT 174 195 repeat SxxSxAPRT) FT 199 212 basic region FT 213 256 helix-loop-helix domain FT 271 292 leucine zipper (L4) XX SF immunologically unrelated with USF44 [24], [22], [7]; SF bends DNA towards the minor groove by 74-82 deg [11]; SF DNA-binding is sensitive to CpG methylation [4]; SF the basic region contacts DNA within the major groove, SF thereby adopting alpha-helical conformation [12]; SF within the homodimer, HLH domain forms a parallel SF left-handed four-helix-bundle [12]; SF SxxSxAPRT repeat: similar to hinge region of immunoglobulins [24]; SF full-length USF requires the leucine zipper for efficient SF DNA-binding [24], mediating DNA-binding homodimers, SF free in solution also homotetramers [12]; SF possible redox regulation via two Cys within HLH domain [13]; SF possible splice variants of 244 AA and 49 AA [24]; SF x44-kDa USF form may be an associated component [7]; SF structural investigations by scanning transmission SF EM [10], CD [12], crystal structure [12]; XX CP ubiquitous XX FF transcriptional activator [31], [33], [7]; FF cooperative interaction with TFII-I [32] and TFIID [23]; FF may have to direct stable preinitiation complex formation FF during chromosome assembly [26]; XX IN T00874; USF; human, Homo sapiens. IN T00878; USF2; human, Homo sapiens. IN T02115; USF2; rat, Rattus norvegicus. XX MX M00121; V$USF_01 MX M00122; V$USF_02 MX M00217; V$USF_C XX BS R02015; AD$IVA2_02; Quality: 2; adenovirus type 2 BS R00992; AD$MLP_07; Quality: 2; adenovirus BS R00994; AD$MLP_09; Quality: 4; adenovirus BS R02082; AD$MLP_38; Quality: 2; adenovirus BS R03501; AD$MLP_40; Quality: 2; adenovirus BS R00693; DUCK$HH5_01; Quality: 4; duck, Cairina moschata BS R04408; HS$A4_02; Quality: 2; human, Homo sapiens BS R04425; HS$APE_01; Quality: 3; human, Homo sapiens BS R04420; HS$CEA_01; Quality: 2; human, Homo sapiens BS R04378; HS$CYCB1_01; Quality: 3; human, Homo sapiens BS R04351; HS$CYCD1_04; Quality: 2; human, Homo sapiens BS R00642; HS$HO_01; Quality: 5; human, Homo sapiens BS R03990; HSV2$VMW65_01; Quality: 4; HSV-2, herpes simplex virus type 2 BS R04412; MOUSE$FCGR3A_01; Quality: 2; mouse, Mus musculus BS R03005; MOUSE$SURF2_05; Quality: 4; mouse, Mus musculus BS R01768; MOUSE$TS_01; Quality: 4; mouse, Mus musculus BS R00443; RAT$GF_03; Quality: 2; rat, Rattus norvegicus BS R00643; RAT$HO_02; Quality: 5; rat, Rattus norvegicus BS R00913; RAT$INS2_01; Quality: 4; rat, Rattus norvegicus BS R04419; RAT$LPK_01; Quality: 1; rat, Rattus norvegicus BS R04436; RAT$MLCC_02; Quality: 2; rat, Rattus norvegicus BS R02259; USF$CONS; Quality: 6 BS R04439; VZV$EARL_01; Quality: 1; VZV, varicella-zoster virus BS R01437; XENLA$TFIIIA_02; Quality: 2; clawed frog, Xenopus laevis BS R01589; XENLA$VITB1_03; Quality: 4; clawed frog, Xenopus laevis XX DR EMBL: X55666; HSUSFMR(r). DR SwissProt: P22415; USF1_HUMAN. DR PIR: S13525; S13525. XX RN [1] RA Carthew R. W., Chodosh L. A., Struhl P. A. RT An RNA polymerase II transcription factor binds to RT an upstream element in the adenovirus major late promoter RL Cell 43:439-448 (1985). RN [2] RA Chodosh L. A., Carthew R. W., Morgan J. G., Crabtree G. R., Sharp P. A. RT The Adenovirus Major Late Transcription Factor Activates RT the Rat gamma-Fibrinogen Promoter RL Science 238:684-688 (1987). RN [3] RA Nikolaev L. G., Glotov B. O., Belyavsky A. V., Grachev S. A., Levin A. V. RT Identification of sequence-specific DNA-binding factors RT by label transfer: application to the adenovirus-2 major late promoter RL Nucleic Acids Res. 16:519-535 (1988). RN [4] RA Watt F., Molloy P. L. RT Cytosine methylation prevents binding to DNA of a RT HeLa cell transcription factor required for optimal RT expression of the adenovirus major late promoter RL Genes Dev. 2:1136-1143 (1988). RN [5] RA Chodosh L. A., Buratowski S., Sharp P. A. RT A Yeast Protein Possesses the DNA-Binding Properties RT of the Adenovirus Major Late Transcription Factor RL Mol. Cell. Biol. 9:820-822 (1989). RN [6] RA Carcamo J., Lobos S., Merino A., Buckbinder L., Weinmann RA R., Natarajan V., Reinberg D. RT Factors Involved in Specific Transcription by Mammalian RNA Polymerase II RL J. Biol. Chem. 264:7704-7714 (1989). RN [7] RA Pognonec P., Roeder R. G. RT Recombinant 43-kDa USF binds to DNA and activates RT transcription in a manner indistinguishable from that RT of natural 43/44-kDa USF RL Mol. Cell. Biol. 11:5125-5136 (1991). RN [8] RA Kirschbaum B. J., Pognonec P., Roeder R. G. RT Definition of the transcriptional activation domain RT of recombinant 43-kilodalton USF RL Mol. Cell. Biol. 12:5094-5101 (1992). RN [9] RA Chodosh L. A., Carthew R. W., Sharp. P. A. RT A single polypeptide possesses the binding and transcription RT activities of the adenovirus major late transcription factor RL Mol. Cell. Biol. 6:4723-4733 (1986). RN [10] RA Hough P. V. C., Mastrangelo I. A., Wall J. S., Hainfeld RA J. F., Sawadogo M., Roeder R. G. RT The gene-specific initiation factor USF (upstream RT stimulatory factor) bound at the adenovirus type 2 RT major late promoter: Mass and three-dimensional structure RL Proc. Natl. Acad. Sci. USA 84:4826-4830 (1987). RN [11] RA Fisher D. E., Parent L. A., Sharp P. A. RT Myc/Max and other helix-loop-helix/leucine zipper RT proteins bend DNA toward the minor groove RL Proc. Natl. Acad. Sci. USA 89:11779-11783 (1992). RN [12] RA Ferrė-DžAmarė A. R., Pognonec P., Roeder R. G., Burley S. K. RT Structure and function of the b/HLH/Z domain of USF RL EMBO J. 13:180-189 (1993). RN [13] RA Pognonec P., Kato H., Roeder R. G. RT The helix-loop-helix/leucine repeat transcription RT factor USF can be functionally regulated in a redox-dependent manner RL J. Biol. Chem. 267:24563-24567 (1992). RN [14] RA van Dyke M. W., Sawadogo M. RT DNA-binding and transcriptional properties of human RT transcription factor TFIID after mild proteolysis RL Mol. Cell. Biol. 10:3415-3420 (1990). RN [15] RA Kovesdi I., Reichel R., Nevins J. R. RT Role of an adenovirus E2 promoter binding factor in RT E1A-mediated coordinate gene control RL Proc. Natl. Acad. Sci. USA 84:2180-2184 (1987). RN [16] RA Deng T., Li Y., Jolliff K., Johnson L. F. RT The Mouse Thymidylate Synthase Promoter: Essential RT Elements Are in Close Proximity to the Transcriptional Initiation Sites RL Mol. Cell. Biol. 9:4079-4082 (1989). RN [17] RA Morgan J. G., Courtois G., Fourel G., Chodosh L. A., RA Campbell L., Evans E., Crabtree G. R. RT Sp1, a CAAT-Binding Factor, and the Adenovirus Major RT Late Promoter Transcription Factor Interact with Functional RT Regions of the Gamma-Fibrinogen Promoter RL Mol. Cell. Biol. 8:2628-2637 (1988). RN [18] RA Moncollin V., Miyamoto N. G., Zheng X. M., Egly J. M. RT Identification of a factor specific for the upstream RT element of the adenovirus-2 major late promoter RL EMBO J. 5:2577-2584 (1986). RN [19] RA Lennard A. C., Egly J. M. RT Thr bidirectional upstream element of the adenovirus-2 RT major late promoter binds a single monomeric molecule of the upstream factor RL EMBO J. 6:3027-3034 (1987). RN [20] RA Sawadogo M., Roeder R. G. RT Interaction of a Gene-Specific Transcription Factor RT with the Adenovirus Major Late Promoter Upstream of the TATA Box Region RL Cell 43:165-175 (1985). RN [21] RA Mondesert G., Kedinger C. RT Cooperation between upstream and downstream elements RT of the adenovirus major late promoter for maximal RT late phase-specific transcription RL Nucleic Acids Res. 19:3221 (1991). RN [22] RA Sawadogo M., van Dyke M., Gregor P. D., Roeder R. G. RT Multiple forms of the human gene-specific transcription RT factor USF. I. Complete purification and identification RT of USF from HeLa cell nuclei RL J. Biol. Chem. 263:11985-11993 (1988). RN [23] RA Sawadogo M. RT Multiple forms of the human gene-specific transcription RT factor USF. II. DNA binding properties and transcriptional RT activity of the purified HeLa USF RL J. Biol. Chem. 263:11994-12001 (1988). RN [24] RA Gregor P. D., Sawadogo M., Roeder R. G. RT The adenovirus major late transcription factor USF RT is a member of the helix-loop-helix group of regulatory RT proteins and binds to DNA as a dimer RL Genes Dev. 4:1730-1740 (1990). RN [25] RA Watt F., Molloy P. L. RT High mobility group proteins 1 and 2 stimulate binding RT of a specific transcription factor to the adenovirus major late promoter RL Nucleic Acids Res. 16:1471-1486 (1988). RN [26] RA Workman J. L., Roeder R. G., Kingston R. E. RT An upstream transcription factor, USF (MLTF), facilitates RT the formation of preinitiation complexes during in vitro chromatin assembly RL EMBO J. 9:1299-1308 (1990). RN [27] RA Kaulen H., Pognonec P., Roeder R. G., Gregor P. D. RT The xenopus B1 factor is closely related to the mammalian RT activator USF and is implicated in the developmental RT regulation of TFIIIA gene expression RL Mol. Cell. Biol. 11:412-424 (1991). RN [28] RA Moncollin V., Stalder R., Verdier J.-M., Sentenac A., Egly J.-M. RT A yeast homolog of the human UEF stimulates transcription RT from the adenovirus 2 major late promoter in yeast RT and in mammalian cell-free systems RL Nucleic Acids Res. 18:4817-4823 (1990). RN [29] RA Dang C. V., Dolde C., Gillison M. L., Kato G. J. RT Discrimination between related DNA sites by a single RT amino acid residue of Myc-related basic-helix-loop-helix proteins RL Proc. Natl. Acad. Sci. USA 89:599-602 (1992). RN [30] RA Beckmann H., Kadesch T. RT The leucine zipper of TFE3 dictates helix-loop-helix RT dimerization specificity RL Genes Dev. 5:1057-1066 (1991). RN [31] RA Potter J. J., Cheneval D., Dang C. V., Resar L. M. S., Mezey E., Yang V. W. RT The upstream stimulatory factor binds to and activates RT the promoter of the rat class I alcohol dehydrogenase gene RL J. Biol. Chem. 266:15457-15463 (1991). RN [32] RA Roy A. L., Meisterernst M., Pognonec P., Roeder R. G. RT Cooperative interaction of an initiator-binding transcription RT initiation factor and the helix-loop-helix activator USF RL Nature 354:245-248 (1991). RN [33] RA Zwartkruis F., Hoeijmakers T., Deschamps J., Meijlink F. RT Characterization of the murine Hox-2.3 promoter: involvement RT of the transcription factor USF (MLTF) RL Mech. Dev. 33:179-190 (1991). XX // AC T00875 XX ID T00875 XX DT 28.01.93 (created); hse. XX FA USF XX SY MLTF; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0012; bHLH-ZIP; 1.3.1.2.2. XX SZ 43/44 kDa (SDS) XX MX M00121; V$USF_01 MX M00122; V$USF_02 MX M00217; V$USF_C XX BS R04408; HS$A4_02; Quality: 3; human, Homo sapiens BS R01697; HS$ADH2_02; Quality: 6; human, Homo sapiens BS R02079; RAT$ADH1_01; Quality: 3; rat, Rattus norvegicus BS R04438; RAT$AMHC_05; Quality: 3; rat, Rattus norvegicus BS R04407; RAT$APP_01; Quality: 3; rat, Rattus norvegicus BS R04432; RAT$FAS_03; Quality: 3; rat, Rattus norvegicus BS R00441; RAT$GF_01; Quality: 4; rat, Rattus norvegicus BS R00913; RAT$INS2_01; Quality: 4; rat, Rattus norvegicus BS R04419; RAT$LPK_01; Quality: 4; rat, Rattus norvegicus BS R04437; RAT$MLCC_03; Quality: 3; rat, Rattus norvegicus BS R04433; RAT$S14_06; Quality: 4; rat, Rattus norvegicus BS R02259; USF$CONS; Quality: 6 XX RN [1] RA Kovesdi I., Reichel R., Nevins J. R. RT Role of an adenovirus E2 promoter binding factor in RT E1A-mediated coordinate gene control RL Proc. Natl. Acad. Sci. USA 84:2180-2184 (1987). RN [2] RA Gregor P. D., Sawadogo M., Roeder R. G. RT The adenovirus major late transcription factor USF RT is a member of the helix-loop-helix group of regulatory RT proteins and binds to DNA as a dimer RL Genes Dev. 4:1730-1740 (1990). RN [3] RA Watt F., Molloy P. L. RT High mobility group proteins 1 and 2 stimulate binding RT of a specific transcription factor to the adenovirus major late promoter RL Nucleic Acids Res. 16:1471-1486 (1988). RN [4] RA Workman J. L., Roeder R. G., Kingston R. E. RT An upstream transcription factor, USF (MLTF), facilitates RT the formation of preinitiation complexes during in vitro chromatin assembly RL EMBO J. 9:1299-1308 (1990). RN [5] RA Kaulen H., Pognonec P., Roeder R. G., Gregor P. D. RT The xenopus B1 factor is closely related to the mammalian RT activator USF and is implicated in the developmental RT regulation of TFIIIA gene expression RL Mol. Cell. Biol. 11:412-424 (1991). RN [6] RA Moncollin V., Stalder R., Verdier J.-M., Sentenac A., Egly J.-M. RT A yeast homolog of the human UEF stimulates transcription RT from the adenovirus 2 major late promoter in yeast RT and in mammalian cell-free systems RL Nucleic Acids Res. 18:4817-4823 (1990). XX // AC T00876 XX ID T00876 XX DT 21.10.92 (created); ewi. XX FA USF XX SY eUSF; XX OS duck, Cairina moschata OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; anseriformes; anatidae XX FF may anchor TFIID to a TATA-less promoter XX MX M00121; V$USF_01 MX M00122; V$USF_02 MX M00217; V$USF_C XX BS R00693; DUCK$HH5_01; Quality: 4; duck, Cairina moschata BS R02078; DUCK$HH5_02; Quality: 4; duck, Cairina moschata BS R02259; USF$CONS; Quality: 6 XX RN [1] RA Duering F., Gerhold H., Seifart K. H. RT Transcription factor USF from duck erythrocytes transactivates RT expression of the histone H5 gene invitro by interacting RT with an intragenic sequence RL Nucleic Acids Res. 18:1225-1231 (1990). RN [2] RA Bungert J., Kober I., Duering F., Seifart K. H. RT Transcription factor eUSF is an essential component RT of isolated transcription complexes on the duck histone RT H5 gene and it mediates the interaction of TFIID with RT a TATA-deficient promoter RL J. Mol. Biol. 223:885-898 (1992). XX // AC T00877 XX ID T00877 XX DT 28.01.93 (created); hse. XX FA USF XX SY MLTF; UEF; eUSF (duck); pf51; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0012; bHLH-ZIP; 1.3.1.2.2. XX SZ 43, 44 kDa (SDS) XX IN T01555; USF2; mouse, Mus musculus. XX MX M00121; V$USF_01 MX M00122; V$USF_02 MX M00217; V$USF_C XX BS R02090; MOUSE$HOX23_08; Quality: 5; mouse, Mus musculus BS R03005; MOUSE$SURF2_05; Quality: 4; mouse, Mus musculus BS R01768; MOUSE$TS_01; Quality: 4; mouse, Mus musculus BS R02259; USF$CONS; Quality: 6 XX RN [1] RA Kovesdi I., Reichel R., Nevins J. R. RT Role of an adenovirus E2 promoter binding factor in RT E1A-mediated coordinate gene control RL Proc. Natl. Acad. Sci. USA 84:2180-2184 (1987). RN [2] RA Gregor P. D., Sawadogo M., Roeder R. G. RT The adenovirus major late transcription factor USF RT is a member of the helix-loop-helix group of regulatory RT proteins and binds to DNA as a dimer RL Genes Dev. 4:1730-1740 (1990). RN [3] RA Watt F., Molloy P. L. RT High mobility group proteins 1 and 2 stimulate binding RT of a specific transcription factor to the adenovirus major late promoter RL Nucleic Acids Res. 16:1471-1486 (1988). RN [4] RA Workman J. L., Roeder R. G., Kingston R. E. RT An upstream transcription factor, USF (MLTF), facilitates RT the formation of preinitiation complexes during in vitro chromatin assembly RL EMBO J. 9:1299-1308 (1990). RN [5] RA Kaulen H., Pognonec P., Roeder R. G., Gregor P. D. RT The xenopus B1 factor is closely related to the mammalian RT activator USF and is implicated in the developmental RT regulation of TFIIIA gene expression RL Mol. Cell. Biol. 11:412-424 (1991). RN [6] RA Moncollin V., Stalder R., Verdier J.-M., Sentenac A., Egly J.-M. RT A yeast homolog of the human UEF stimulates transcription RT from the adenovirus 2 major late promoter in yeast RT and in mammalian cell-free systems RL Nucleic Acids Res. 18:4817-4823 (1990). XX // AC T00878 XX ID T00878 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA USF2 XX SY FIP; USF II; USF44; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0012; bHLH-ZIP; 1.3.1.2.3. XX SZ 44 kDa (SDS) XX SF immunologically unrelated to USF1 [4]; SF there are splice variants and variants from alternative SF translation initiation and polyadenylation [1]; SF leucine zipper is required for DNA-binding [1]; XX CP ubiquitous XX FF cooperative transcriptional stimulation through AP-1 FF sites by interaction with c-Fos [2]; XX IN T00123; c-Fos; human, Homo sapiens. IN T00874; USF; human, Homo sapiens. IN T00878; USF2; human, Homo sapiens. IN T02115; USF2; rat, Rattus norvegicus. XX BS R00336; AD$E2L_04; Quality: 6; adenovirus type 2 BS R00992; AD$MLP_07; Quality: 2; adenovirus BS R04408; HS$A4_02; Quality: 2; human, Homo sapiens BS R04419; RAT$LPK_01; Quality: 1; rat, Rattus norvegicus XX DR EMBL: M77476; HSMRNA(r). DR EMBL: S50537; S50537(r). XX RN [1] RA Sirito M., Walker S., Lin Q., Kozlowski M. T., Klein W. H., Sawadogo M. RT Members of the USF family of helix-loop-helix proteins RT bind DNA as homo- as well as heterodimers RL Gene Expression 2:231-240 (1992). RN [2] RA Blanar M. A., Rutter W. J. RT Interaction cloning: identification of a helix-loop-helix RT zipper protein that interacts with c-fos RL Science 256:1014-1018 (1992). RN [3] RA Goding C. R., Temperley S. M., Fisher F. RT Multiple transcription factors interact with the adenovirus-2 RT EII-late promoter: evidence for a new CCAAT recognition factor RL Nucleic Acids Res. 15:7761-7780 (1987). RN [4] RA Gregor P. D., Sawadogo M., Roeder R. G. RT The adenovirus major late transcription factor USF RT is a member of the helix-loop-helix group of regulatory RT proteins and binds to DNA as a dimer RL Genes Dev. 4:1730-1740 (1990). XX // AC T00879 XX ID T00879 XX DT 15.10.92 (created); ewi. XX FA vaccinia virus DNA-binding protein XX OS vaccinia virus OC viridae; ds-DNA enveloped viruses; poxviridae; chordopoxvirinae; OC orthopoxvirus XX SZ 130 kDa XX RN [1] RA Yuen L., Davison A. J., Moss B. RT Early promoter-binding factor form vaccinia virions RL Proc. Natl. Acad. Sci. USA 84:6069-6073 (1987). XX // AC T00880 XX ID T00880 XX DT 20.10.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA Vav XX SY p95vav; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0013; HLH-ZIP; . XX SZ 846 AA; 98.4 kDa (cDNA) XX SQ MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV SQ NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI SQ AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS SQ EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI SQ EDLLRVHTHFLKEMKEALGTPGAPNLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA SQ REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEQGNLRLAL SQ DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM SQ DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ SQ GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF SQ YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF SQ QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH SQ GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHTVK SQ IMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVG SQ STKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEE SQ DYSEYC XX SC SwissProt #P15498 XX SF SH3 (2x), SH2, acidic region SF no basic region XX CP hematopoietic cells XX FF Protooncogene product, loss of HLH activates transforming potential XX DR EMBL: X16316; HSVAVPO(r). DR EMBL: M59834; HSVAVPO1(g). DR SwissProt: P15498; VAV_HUMAN. XX RN [1] RA Katzav S., Cleveland J. L., Heslop H. E., Pulido D. RT Loss of the amino-terminal helix-loop-helix domain RT of the vav proto-oncogene activates its transforming potential RL Mol. Cell. Biol. 11:1912-1920 (1991). RN [2] RA Bustelo X. R., Ledbetter J. A., Barbacid M. RT Product of vav proto-oncogene defines a new class RT of tyrosine protein kinase substrates RL Nature 356:68-71 (1992). RN [3] RA Margolis B., Hu P., Katzav S., Li W., Oliver J. M., RA Ullrich A., Weiss A., Schlessinger J. RT Tyrosine phosphorylation of vav proto-oncogene product RT containing SH2 domain and transcription factor motifs RL Nature 356:71-74 (1992). XX // AC T00881 XX ID T00881 XX DT 28.01.93 (created); hse. DT 27.08.96 (updated); ewi. XX FA VBP XX SY DBP; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX HO DBP, TEF XX CL C0008; bZIP; 1.1.4.0.2. XX SZ 313 AA; 34.3 kDa (cDNA) XX SQ MPGRAAHQEAAAAGGAAAEPTAAGGSAGAVAQQPEQQGLAGAFPLVLKKLMENPPRDARL SQ DKEKKIKLEEDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPSS SQ PTHLDLNQNPLMPVAKLEEKEPASASTGSPVSSSSTAVYQQSEAASSTESPPQNERNTPS SQ PIDPDCVEVEVNFNPDPADLVLSSVPGGELFNPRKHKFTEEDLKPQPMIKKAKKVFVPDE SQ QKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGRCK SQ NIVSKYETRYGPL XX SC translated and edited from EMBL #U09221 and #U09222 XX FT 245 267 basic region FT 271 299 leucine zipper (IL3C) XX SF dimerizes free in solution and on DNA [3]; SF thermodynamics of the leucine zipper structure [1]; SF CD spectroscopy [1]; SF fork region between basic and zipper subdomain is SF essential for DNA-half-site specificity [2]; XX CP (liver) XX FF appears to have a pivotal role in the estrogen-dependent FF regulation of the chicken vitellogenin gene; FF similar to DBP (rat) XX IN T00881; VBP; chick, Gallus gallus. XX MX M00228; V$VBP_01 XX BS R03497; CHICK$VIT2_21; Quality: 2; chick, Gallus gallus BS R02260; VBP$CONS; Quality: 6 XX DR EMBL: U09221; GG09221(r). DR EMBL: U09222; GG09222(g). XX RN [1] RA Krylov D., Mikhailenko I., Vinson C. RT A thermodynamic scale for leucine zipper stability RT and dimerization specifity: e and g interhelical interactions RL EMBO J. 13:2849-2861 (1994). RN [2] RA Haas N. B., Cantwell C. A., Johnson P. F., Burch J. B. E. RT DNA-binding specificity of the PAR basic leucine zipper RT protein VBP partially overlaps those of the C/EBP RT and CREB/ATF families and is influenced by domains RT that flank the core basic region RL Mol. Cell. Biol. 15:1923-1932 (1995). RN [3] RA Iyer S. V., Davis D. L., Seal S. N., Burch B. E. RT Chicken vitellogenin gene-binding protein, a leucine RT zipper transcription factor that binds to an important RT control element in the chicken vitellogenin II promoter, RT is related to rat DBP RL Mol. Cell. Biol. 11:4863-4875 (1991). XX // AC T00882 XX ID T00882 XX DT 28.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA VDR XX SY vitamin D receptor; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); 2.1.2.4.1. XX SZ 423 AA; 47.8 kDa (cDNA) XX SQ MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC SQ PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSL SQ RPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSS SQ SSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGF SQ AKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAG SQ HTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQ SQ TYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN SQ EIS XX SC SwissProt #P13053 XX SF phosphorylation XX FF member of the steroid hormone receptor superfamily; FF requires an additional nuclear accessory protein, FF different from RXR-alpha or RXR-beta, for DNA-binding XX IN T01345; RXR-alpha; human, Homo sapiens. IN T01349; RXR-beta; rat, Rattus norvegicus. IN T01355; TRAP; human, Homo sapiens. XX BS R01188; RAT$OC_01; Quality: 1; rat, Rattus norvegicus BS R02261; VDR$CONS_01; Quality: 6 BS R03524; VDR$CONS_02; Quality: 6 XX DR EMBL: J04147; RNDHVRD3(r). DR SwissProt: P13053; VDR_RAT. XX RN [1] RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado RA J., Pike J. W., Evans R. M. RT Jun-Fos and receptors for vitamins A and D recognize RT a common response element in the human osteocalcin gene RL Cell 61:497-504 (1990). RN [2] RA Ross T. K., Prahl J. M., Herzberg I. M., DeLuca H. F. RT Baculovirus-mediated expression of retinoic acid receptor RT type gamma in cultured insect cells reveals a difference RT in specific DNA-binding behavior with the 1,25-dihydroxyvitamin D3 receptor RL Proc. Natl. Acad. Sci. USA 89:10282-10286 (1992). RN [3] RA Baker A. R., McDonnell D. P., Hughes M., Crisp T. RA M., Mangelsdorf D. J., Haussler M. R., Pike J. W., Shine J., O'Malley B. W. RT Cloning and expression of full-length cDNA encoding human vitamin D receptor RL Proc. Natl. Acad. Sci. USA 85:3294-3298 (1988). XX // AC T00883 XX ID T00883 XX DT 28.01.93 (created); hse. DT 10.01.96 (updated); hiwi. XX FA VDR XX SY vitamin D receptor; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec); . XX SF phosphorylation XX FF member of the steroid hormone receptor superfamily XX IN T01345; RXR-alpha; human, Homo sapiens. IN T01349; RXR-beta; rat, Rattus norvegicus. IN T01355; TRAP; human, Homo sapiens. XX BS R02261; VDR$CONS_01; Quality: 6 BS R03524; VDR$CONS_02; Quality: 6 XX RN [1] RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado RA J., Pike J. W., Evans R. M. RT Jun-Fos and receptors for vitamins A and D recognize RT a common response element in the human osteocalcin gene RL Cell 61:497-504 (1990). RN [2] RA Baker A. R., McDonnell D. P., Hughes M., Crisp T. RA M., Mangelsdorf D. J., Haussler M. R., Pike J. W., Shine J., O'Malley B. W. RT Cloning and expression of full-length cDNA encoding human vitamin D receptor RL Proc. Natl. Acad. Sci. USA 85:3294-3298 (1988). XX // AC T00884 XX ID T00884 XX DT 15.10.92 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA VDR XX SY vitamin D receptor; XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC aves; neornithes; neognathae; galliformes; phasianidae XX CL C0002; CC (rec); 2.1.2.4.1. XX SZ 58, 60 kDa (SDS) XX SF phosphorylation XX IN T01345; RXR-alpha; human, Homo sapiens. IN T01349; RXR-beta; rat, Rattus norvegicus. IN T01355; TRAP; human, Homo sapiens. XX BS R02261; VDR$CONS_01; Quality: 6 BS R03524; VDR$CONS_02; Quality: 6 XX RN [1] RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado RA J., Pike J. W., Evans R. M. RT Jun-Fos and receptors for vitamins A and D recognize RT a common response element in the human osteocalcin gene RL Cell 61:497-504 (1990). RN [2] RA McDonnell D. P., Mangelsdorf D. J., Pike J. W., Haussler RA M. R., O'Malley B. W. RT Molecular cloning of complementary DNA encoding the RT avian receptor for vitamin D RL Science 235:1214-1217 (1987). RN [3] RA Baker A. R., McDonnell D. P., Hughes M., Crisp T. RA M., Mangelsdorf D. J., Haussler M. R., Pike J. W., Shine J., O'Malley B. W. RT Cloning and expression of full-length cDNA encoding human vitamin D receptor RL Proc. Natl. Acad. Sci. USA 85:3294-3298 (1988). XX // AC T00885 XX ID T00885 XX DT 28.01.93 (created); hse. DT 23.05.96 (updated); rkn. XX FA VDR XX SY vitamin D receptor; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec); 2.1.2.4.1. XX SZ 427 AA; 48.3 kDa (cDNA) XX SQ MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC SQ PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL SQ RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG SQ DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK SQ VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV SQ TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS SQ NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE SQ VFGNEIS XX SC SwissProt #P11473 XX FT 244 263 heterodimerization XX SF phosphorylation XX FF member of the steroid hormone receptor superfamily XX IN T01331; RXR-alpha; mouse, Mus musculus. IN T01332; RXR-beta; mouse, Mus musculus. IN T01334; RXR-beta; human, Homo sapiens. IN T01345; RXR-alpha; human, Homo sapiens. IN T01349; RXR-beta; rat, Rattus norvegicus. IN T01355; TRAP; human, Homo sapiens. IN T01359; RXR-alpha; clawed frog, Xenopus laevis. XX BS R01187; HS$OC_01; Quality: 6; human, Homo sapiens BS R04374; HS$WAF1_02; Quality: 2; human, Homo sapiens BS R02261; VDR$CONS_01; Quality: 1 BS R03524; VDR$CONS_02; Quality: 6 XX DR EMBL: X67482; HSVD3R(r). DR EMBL: J03258; HSVDR(r). DR SwissProt: P11473; VDR_HUMAN. XX RN [1] RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado RA J., Pike J. W., Evans R. M. RT Jun-Fos and receptors for vitamins A and D recognize RT a common response element in the human osteocalcin gene RL Cell 61:497-504 (1990). RN [2] RA Kliewer S. A., Umesono K., Mangelsdorf D. J., Evans R. M. RT Retinoid X receptor interacts with nuclear receptors RT in retinoic acid, thyroid hormone and vitamin D3 signalling RL Nature 355:446-449 (1992). RN [3] RA Yu V. C., Delsert C., Andersen B., Holloway J. M., RA Devary O. V., Naeaer A. M., Kim S. Y., Boutin J. M., RA Glass C. K., Rosenfeld M. G. RT RXRbeta: a coregulator that enhances binding of retinoic RT acid, thyroid hormone, and vitamin D receptors of RT their cognate response elements RL Cell 67:1251-1266 (1991). RN [4] RA Rosen E. D., Beninghof E. G., Koenig R. J. RT Dimerization interfaces of thyroid hormone, retinoic RT acid, vitamin D, and retinoid X receptors RL J. Biol. Chem. 268:11534-11541 (1993). RN [5] RA Baker A. R., McDonnell D. P., Hughes M., Crisp T. RA M., Mangelsdorf D. J., Haussler M. R., Pike J. W., Shine J., O'Malley B. W. RT Cloning and expression of full-length cDNA encoding human vitamin D receptor RL Proc. Natl. Acad. Sci. USA 85:3294-3298 (1988). XX // AC T00886 XX ID T00886 XX DT 15.10.92 (created); ewi. XX FA v-ErbA XX OS AEV, avian erythroblastosis virus OC viridae; ss-RNA enveloped viruses; positive strand OC RNA viruses; retroviridae; oncovirinae; type C oncovirus OC group; avian type C oncoviruses XX FT 16 17 serine-phosphorylation by PKA or PKC XX FF enhances transcriptional activation by c-Jun due to FF antagonistic action towards RAR or T3R; FF causes neoplasia, most likely due to interference FF with responses to RAR rather than to T3R; FF no T3-binding because of a Pro(364)->Ser(366) exchange compared to c-ErbA; FF phosphorylation is required for oncogenicity XX MX M00239; V$T3R_01 XX BS R01465; AS$TR_01; Quality: 6 BS R02020; AS$VERBA_01; Quality: 1 BS R04090; CHICK$CA2_01; Quality: 2; chick, Gallus gallus BS R01673; CHICK$LYS_15; Quality: 1; chick, Gallus gallus BS R02595; MOMLV$MOMULV_19; Quality: 6; Mo-MuLV, moloney murine leukemia virus BS R02151; VERBA$CONS; Quality: 1 XX RN [1] RA Sharif M., Privalsky M. L. RT V-erbA and c-erbA proteins enhance transcriptional activation by c-jun RL Oncogene 7:953-960 (1992). RN [2] RA Sharif M., Privalsky M. L. RT v-erbA oncogene function in neoplasia correlates with RT its ability to repress retinoic acid receptor action RL Cell 66:885-893 (1991). RN [3] RA Desbois C., Aubert D., Legrand C., Pain B., Samarut J. RT A novel mechanism of action for v-erbA: abrogation RT of the inactivation of transcription factor AP-1 by RT retinoic acid and thyroid hormone receptors RL Cell 67:731-740 (1991). RN [4] RA Selmi S., Samuels H. H. RT Thyroid hormone receptor / and v-erbA: a single amino RT acid difference in the C-terminal region influences RT dominant negative activity and receptor dimer formation RL J. Biol. Chem. 266:11589-11593 (1991). RN [5] RA Glineur C., Zenke M., Beug H., Ghysdael J. RT Phosphorylation of the v-erbA protein is required RT for its function as an oncogene RL Genes Dev. 4:1663-1676 (1990). RN [6] RA Goldberg Y., Glineur C., Gesquiere J.-C., Ricouart RA A., Sap J., Vennstroem B., Ghysdael J. RT Activation of protein kinase C or cAMP-dependent protein RT kinase increases phosphorylation of the c-erbA-encoded RT thyroid hormone receptor and of the v-erbA-encoded protein RL EMBO J. 7:2425-2433 (1988). RN [7] RA Damm K., Thompson C. C., Evans R. M. RT Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist RL Nature 339:593-597 (1989). RN [8] RA Sap J., Munoz A., Schmitt J., Stunnenberg H., Vennstroem B. RT Repression of transcription mediated at a thyroid RT hormone response element by the v-erb-A oncogene product RL Nature 340:242 (1989). RN [9] RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA RT oncogene is in part due to a mutation in the DNA binding RT domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). XX // AC T00887 XX ID T00887 XX DT 15.10.92 (created); ewi. DT 23.08.96 (updated); ewi. XX FA VETF XX SY D6R gene product; XX OS vaccinia virus OC viridae; ds-DNA enveloped viruses; poxviridae; chordopoxvirinae; OC orthopoxvirus XX SZ 637 AA; 73 kDa (gene), 70 kDa (SDS) XX BS R01641; VAV$RP22_01; Quality: 6; vaccinia virus BS R01558; VAV$VGF_01; Quality: 6; vaccinia virus XX DR EMBL: M35027; PXVACCG(g). DR EMBL: M15058; PXVACHIN(g). DR SwissProt: P20634; ETF1_VACCC. DR SwissProt: P04308; ETF1_VACCV. XX RN [1] RA Broyles S. S., Fesler B. S. RT Vaccinia Virus Gene Encoding a Component of the Viral RT Early Transcription Factor RL J. Virol. 64:1523-1529 (1990). XX // AC T00888 XX ID T00888 XX DT 12.03.93 (created); ewi. DT 23.05.96 (updated); rkn. XX FA v-Fos XX SY gag-fos; XX OS FBR MuLV, FBR murine osteosarcoma virus OC viridae; ss-RNA enveloped viruses; positive strand OC RNA viruses; retroviridae; oncovirinae; type C oncovirus OC group; mammalian type C oncoviruses XX CL C0008; bZIP; 1.1.1.2.1. XX SZ 244 AA; 26.6 kDa (gene) XX SQ DSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANFIPTETAISTSPDLQWLVQPTLVSS SQ VAPSQTRAPHPYGLPTQSAGAYARAGMVKTVSGGRAQSIGRRGKVEQLSPEEEVKRRIRR SQ ERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPAC SQ KIPDDLGFPEEMSVASLDLTGGLLPLLNDPEPKPSLEPVKSSFDDFLFPASSGHSGFISM SQ AGWQ XX SC SwissProt #P29176 XX IN T00131; c-Jun; mouse, Mus musculus. IN T00132; c-Jun; rat, Rattus norvegicus. IN T00133; c-Jun; human, Homo sapiens. IN T00134; c-Jun; chick, Gallus gallus. IN T00135; c-Jun; hamster. IN T01430; v-Maf; AS42, avian musculoaponeurotic fibrosarcoma virus. IN T01434; MafK; chick, Gallus gallus. IN T01436; MafF; chick, Gallus gallus. IN T01437; MafG; chick, Gallus gallus. XX BS R02963; AS$AP1_02; Quality: 6 BS R04116; AS$VMAF_02; Quality: 2 XX DR EMBL: K02712; REFBRMU(g). DR SwissProt: P29176; FOSX_MSVFR. DR PIR: B23244; TVMVFB. XX RN [1] RA Kataoka K., Noda M., Nishizawa M. RT Maf nuclear oncoprotein recognizes sequences related RT to an AP-1 site and forms heterodimers with both Fos and Jun RL Mol. Cell. Biol. 14:700-712 (1994). RN [2] RA Kamata N., Jotte R. M., Holt J. T. RT Myristylation alters DNA-binding activity and transactivation RT of FBR (gag-fos) protein RL Mol. Cell. Biol. 11:765-772 (1991). XX // AC T00889 XX ID T00889 XX DT 15.10.92 (created); ewi. DT 20.11.96 (updated); ewi. XX FA vHNF-1 XX SY HNF-1beta; LF-B3 (mouse); vHNF-1A; vHNF1; XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.1.12.2.1. XX SZ 557 AA; 61.4 kDa (cDNA), 72 kDa (SDS) XX SQ MVSKLTSLQQELLSALLSSGVTKEVLIQALEELLPSPNFGVKLETLPLSPGSGADLDTKP SQ VFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWR SQ AAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL SQ RQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQNQGPGQSEDACSEPTNKKMRRNRFKWGP SQ ASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWF SQ ANRRKEEAFRQKLAMDAYSSNQTHNLNPLLTHGSPHHQPSSSPPNKLSGVRYSQPGNNEV SQ TSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHSLLSPDSKMISVSGGGLPPVSTLTNIH SQ SLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQGVPVINSVASSLAALQPVQFSQQLHS SQ PHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSI SQ NTLTSMSSSKQCPLQAW XX SC SwissProt #P23899 XX FT 1 32 dimerization domain [7]; FT 231 311 homeo domain FT 167 192 POUs A subdomain homology XX FF activator, may modulate the activity of HNF-1 [1]; FF predominantly found in dedifferentiated hepatoma cells [5]; FF expressed in several endodermal and mesodermal embryonal FF tissues before HNF-1 [3]; XX IN T00368; HNF-1A; human, Homo sapiens. IN T00369; HNF-1; rat, Rattus norvegicus. IN T01211; HNF-1; mouse, Mus musculus. XX BS R00118; HS$A1ANTR_05; Quality: 6; human, Homo sapiens BS R00099; RAT$ALBU_23; Quality: 6; rat, Rattus norvegicus BS R00438; RAT$BF_02; Quality: 6; rat, Rattus norvegicus BS R02175; VHNF1$CONS; Quality: 6 XX DR EMBL: X56546; RNVHNF1(r). DR SwissProt: P23899; HNFB_RAT. DR PIR: S15342; S15342. XX RN [1] RA Babajko S., Tronch J. F., Groyer A. RT Liver-specific expression of human insulin-like growth RT factor binding protein 1: Functional role of transcription RT factor HNF1 in vivo RL Proc. Natl. Acad. Sci. USA 90:272-276 (1993). RN [2] RA Menoud P.-A., Matthies R., Hofsteenge J., Nagamine Y. RT Purification and cDNA cloning of a transcription factor RT which functionally cooperates within a cAMP regulatory RT unit in the porcine uPA gene RL Nucleic Acids Res. 21:1845-1852 (1993). RN [3] RA Ott M.-O., Rey-Campos J., Cereghini S., Yaniv M. RT vHNF1 is expressed in epithelial cells of distinct RT embryonic origin during development and precedes HNF1 expression RL Mech. Dev. 36:47-58 (1991). RN [4] RA Baumhueter S., Courtois G., Crabtree G. R. RT A variant nuclear protein in dedifferentiated hepatoma RT cells binds to the same functional sequences in the RT beta fibrinogen gene promoter as HNF-1 RL EMBO J. 7:2485-2493 (1988). RN [5] RA Cereghini S., Yaniv M., Cortese R. RT Hepatocyte dedifferentiation and extinction is accompanied RT by a block in the synthesis of mRNA coding for the RT transcription factor HNF1/LFB1 RL EMBO J. 9:2257-2263 (1990). RN [6] RA Rey-Campos J., Chouard T., Yaniv M., Cereghini S. RT vHNF1 is a homeoprotein that activates transcription RT and forms heterodimers with HNF1 RL EMBO J. 10:1445-1457 (1991). RN [7] RA Mendel D. B., Hansen L. P., Graves M. K., Conley P. B., Crabtree G. R. RT HNF-1alpha and HNF-1beta (vHNF-1) share dimerization RT and homeo domains, but not activation domains, and RT form heterodimers in vitro RL Genes Dev. 5:1042-1056 (1991). XX // AC T00890 XX ID T00890 XX DT 26.01.93 (created); hse. DT 20.11.96 (updated); ewi. XX FA vHNF-1 XX SY LF-B3; LFB3; vHNF-1A; vHNF1; XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.1.12.2.1. XX SZ 559 AA; 61.7 kDa (cDNA), 72 kDa (SDS) XX SQ MVSKLTSLQQELLSALLSSGVTKEVLIQALEELLPSPNFGVKLETLPLSPGSGADLDTKP SQ VFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWR SQ AAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL SQ RQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQNQGPGQSEDTCSEPTNKKMRRNRFKWGP SQ ASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWF SQ ANRRKEEAFRQKLAMDAYSSNQTHNLNPLLTHGSPHHQPSSSPPNKMSGVRYNQPGNNEV SQ TSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHSLLSPDSKMQITVSGGGLPPVSTLTNI SQ HSTHSPPQSPQSQNLIMTPLSGVMAIAQSLNTSQAQGVPVINSVASSLAALQPVQFSQQL SQ HSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEHTQYSHTSRFPSAMVVTDTS SQ SINTLTSMSSSKQCPLQAW XX SC SwissProt #P27889 XX FT 1 32 dimerization domain (by similarity) FT 231 311 homeo domain FT 167 192 POUs A subdomain homology XX CP kidney, lung, (liver, ovary, intestine, stomach: weak CP mRNA-signal), epithel of endo- and mesodermal origin CN spleen, brain, heart, thymus XX FF induced in F9 cells by retinoic acid, max. after 24 hours [2]; XX IN T00368; HNF-1A; human, Homo sapiens. IN T00369; HNF-1; rat, Rattus norvegicus. IN T01211; HNF-1; mouse, Mus musculus. XX BS R02193; LFB3$CONS; Quality: 6 BS R00439; RAT$BF_03; Quality: 6; rat, Rattus norvegicus BS R02175; VHNF1$CONS; Quality: 6 XX DR EMBL: X55842; MMLFB3(r). DR SwissProt: P27889; HNFB_MOUSE. DR PIR: S15341; S15341. XX RN [1] RA Menoud P.-A., Matthies R., Hofsteenge J., Nagamine Y. RT Purification and cDNA cloning of a transcription factor RT which functionally cooperates within a cAMP regulatory RT unit in the porcine uPA gene RL Nucleic Acids Res. 21:1845-1852 (1993). RN [2] RA Kuo C. J., Mendel D. B., Hansen L. P., Crabtree G. R. RT Independent regulation of HNF-1alpha and HNF-1beta RT by retinoic acid in F9 teratocarcinoma cells RL EMBO J. 10:2231-2236 (1991). RN [3] RA De Simone V., De Magistratis L., Lazzaro D., Gerstner RA J., Monaci P., Nicosia A., Cortese R. RT LFB3, a heterodimer-forming homeoprotein of the LFB1 RT family, is expressed in specialized epithelia RL EMBO J. 10:1435-1443 (1991). RN [4] RA Mendel D. B., Hansen L. P., Graves M. K., Conley P. B., Crabtree G. R. RT HNF-1alpha and HNF-1beta (vHNF-1) share dimerization RT and homeo domains, but not activation domains, and RT form heterodimers in vitro RL Genes Dev. 5:1042-1056 (1991). XX // AC T00891 XX ID T00891 XX DT 26.01.93 (created); hse. DT 19.11.96 (updated); ewi. XX FA vHNF-1A XX SY HNF-1beta; vHNF-1; XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; OC tetrapoda; mammalia; eutheria; primates XX CL C0007; POU; 3.1.1.12.2.1. XX SZ 557 AA; 61.3 kDa (cDNA), 72 kDa (SDS) XX SQ MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKP SQ VFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWR SQ AAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL SQ RQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGP SQ ASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWF SQ ANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEI SQ TSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIH SQ SLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHS SQ PHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSI SQ STLTNMSSSKQCPLQAW XX SC SwissProt #P35680 XX FT 1 32 dimerization domain (by similarity) FT 183 208 missing in splice variant vHNF-1B FT 234 311 homeo domain FT 350 557 replaced by 350-399 in splice variant vHNF-1C FT 167 192 POUs A subdomain homolog XX SF splice variant vHNF-1B exhibits an internal deletion, SF variant vHNF-1C lacks the C-terminal part due to usage SF of another poly(A) signal [1]; XX CP liver, lung XX FF activator, higher activity and higher DNA-binding affinity than vHNF-1B [2]; XX IN T01953; vHNF-1B; human, Homo sapiens. IN T01954; vHNF-1C; human, Homo sapiens. XX BS R02175; VHNF1$CONS; Quality: 6 XX DR EMBL: X58840; HSVHNF1(r). DR SwissProt: P35680; HNFB_HUMAN. DR PIR: S34412; S34412. XX RN [1] RA Bach I., Yaniv M. RT More potent transcriptional activators or a transdominant RT inhibitor of the HNF1 homeoprotein family are generated RT by alternative RNA processing RL EMBO J. 12:4229-4242 (1993). RN [2] RA Ringeisen F., Rey-Campos J., Yaniv M. RT The transactivation potential of variant hepatocyte RT nuclear factor 1 is modified by alternative splicing RL J. Biol. Chem. 268:25706-25711 (1993). RN [3] RA Bach I., Mattei M.-G., Cereghini S., Yaniv M. RT Two members of an HNF1 homeoprotein family are expressed in human liver RL Nucleic Acids Res. 19:3553-3559 (1991). XX // AC T00892 XX ID T00892 XX DT 12.03.93 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA VITF XX OS vaccinia virus/human, Homo sapiens OC empty XX SF 2 activities (VITF-A, -B) XX FF induction of intermediate transcription XX BS R03086; VAV$VAVI_01; Quality: 6; vaccinia virus XX RN [1] RA Vos J. C., Sasker M., Stunnenberg H. G. RT Promoter melting by a stage-specific vaccinia virus RT transcription factor is independent of the presence of RNA polymerase RL Cell 65:105-113 (1991). XX // AC T00893 XX ID T00893 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA v-Jun XX OS ASV, avian sarcoma virus OC viridae; ss-RNA enveloped viruses; positive strand OC RNA viruses; retroviridae; oncovirinae; type C oncovirus OC group; avian type C oncoviruses; avian sarcoma viruses XX CL C0008; bZIP; 1.1.6.0.3. XX SQ VPPLRGLCSMSAKMEPTFYEDALNASFAPPESGGYGYNNADILTSPDVGLLKLASPELER SQ LIIQSSNGLITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHNQNTLPSVTSAAQPVS SQ GGMAPVSSMAGGGSFNTSLHSEPPVYANLSNFNPNALNSAPNYNANRMGYAPQHHINPQM SQ PVQHPRLQALKEEPQTVPEMPGETPPLFPIDMESQERIKAERKRMRNRIAASKSRKRKLE SQ RIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF XX SC SwissProt #P05411 XX IN T00893; v-Jun; ASV, avian sarcoma virus. IN T01430; v-Maf; AS42, avian musculoaponeurotic fibrosarcoma virus. XX MX M00036; V$VJUN_01 XX BS R04116; AS$VMAF_02; Quality: 2 BS R00678; HA$H32_01; Quality: 6; hamster BS R00235; HS$CLASE_01; Quality: 6; human, Homo sapiens BS R01037; HS$MT2A_08; Quality: 6; human, Homo sapiens BS R01384; SV$SV40_16; Quality: 6; SV40, simian virus 40 BS R01394; SV$SV40_26; Quality: 6; SV40, simian virus 40 BS R01412; SV$SV40_44; Quality: 6; SV40, simian virus 40 XX DR EMBL: M16266; REACSJUN(r). DR SwissProt: P05411; TJUN_AVIS1. XX RN [1] RA Turner R., Tjian R. RT Leucine repeats and an adjacent DNA binding domain RT mediate the formation of functional cFos-cJun heterodimers RL Science 243:1689-1694 (1989). RN [2] RA Bos T. J., Bohmann D., Tsuchie H., Tjian R., Vogt P. K. RT v-jun encodes a nuclear protein with enhancer binding properties of AP-1 RL Cell 52:705-712 (1988). RN [3] RA Bohmann D., Tjian R. RT Biochemical analysis of transcriptional activation RT by Jun: Differential activity of c- and v-Jun RL Cell 59:709-717 (1989). RN [4] RA Kataoka K., Noda M., Nishizawa M. RT Maf nuclear oncoprotein recognizes sequences related RT to an AP-1 site and forms heterodimers with both Fos and Jun RL Mol. Cell. Biol. 14:700-712 (1994). RN [5] RA Cavalieri F., Ruscio T., Tinoco R., Benedict S., Davis C., Vogt P. K. RT Isolation of three new Avian Sarcoma Viruses: ASV 9, ASV 17, and ASV 25 RL Virology 143:680-683 (1985). RN [6] RA Vogt P.K., Bos T.J., Doolittle R.F. RT Homologe between the DNA-binding domain of the GCN4 RT regulatory protein of yeast and the carboxyl-terminal RT region of a protein coded for by the oncogene jun RL Proc. Natl. Acad. Sci. USA 84:3316-3319 (1987). RN [7] RA Maki Y., Bos T.J., Davis C., Starbuck M., Vogt P.K. RT Avian sarcoma virus 17 carries the jun oncogene RL Proc. Natl. Acad. Sci. USA 84:2848-2852 (1987). RN [8] RA Angel P., Allegretto E. A., Okino S. T., Hattori K., RA Boyle W. J., Hunter T., Karin M. RT Oncogene jun encodes a sequence-specific trans-activator similar to AP-1 RL Nature 332:166-171 (1988). RN [9] RA Imler J. L., Ugarte E., Wasylyk C., Wasylyk B. RT v-Jun is a transcriptional activator, but not in all cell-lines RL Nucleic Acids Res. 16:3005- (1988). RN [10] RA Chida K., Vogt P. K. RT Nuclear translocation of viral Jun but not of cellular RT Jun is cell cycle dependent RL Proc. Natl. Acad. Sci. USA 89:4290-4294 (1992). RN [11] RA Sharma A., Bos T. J., Pekkala-Flagan A., Vogt P. K., Lee A. S. RT Interaction of cellular factors related to the Jun RT oncoprotein with the promoter of a replication-dependent RT hamster histone H3.2 gene RL Proc. Natl. Acad. Sci. USA 86:491-495 (1989). XX // AC T00894 XX ID T00894 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA Vmw65 XX SY ICP25; VP16; alpha-TIF; XX OS HSV-1, herpes simplex virus type 1 OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae XX SZ 490 AA; 54.3 kDa (cDNA), 64 kDa (SDS) XX SQ MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAA SQ LFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYV SQ PERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALY SQ RYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILW SQ AAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIRE SQ HLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMR SQ EHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSL SQ GDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFT SQ DALGIDEYGG XX SC SwissProt #P06492 XX FT 413 490 acidic region (strong trans-activating FT domain), also TBP-binding domain (KD = 200 nM) XX FF induces transciption of immediate-early viral (HSV) genes XX IN T00118; CFF; human, Homo sapiens. IN T00641; Oct-1; human, Homo sapiens. IN T00642; Oct-1; clawed frog, Xenopus laevis. IN T00643; Oct-1; rat, Rattus norvegicus. IN T00644; Oct-1A; mouse, Mus musculus. IN T00794; TBP; human, Homo sapiens. IN T00795; TBP; fission yeast, Schizosaccharomyces pombe. IN T00796; TBP; mouse, Mus musculus. IN T00797; TBP; fruit fly, Drosophila melanogaster. IN T00798; TBP; yeast, Saccharomyces cerevisiae. IN T00959; Oct-1; monkey, Cercopithecus aethiops. IN T01031; Oct-1; chick, Gallus gallus. IN T01157; Oct-1; gibbon ape, Hylobates lar. IN T01862; Oct-1B; mouse, Mus musculus. IN T01863; Oct-1C; mouse, Mus musculus. XX BS R00810; HSV1$IE1_01; Quality: 6; HSV-1, herpes simplex virus type 1 BS R01917; HSV1$IE1_03; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00812; HSV1$IE2_01; Quality: 6; HSV-1, herpes simplex virus type 1 BS R02733; HSV1$IE2_03; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00814; HSV1$IE3_02; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00815; HSV1$IE3_03; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00820; HSV1$IE3_08; Quality: 6; HSV-1, herpes simplex virus type 1 BS R00824; HSV1$IE4_02; Quality: 6; HSV-1, herpes simplex virus type 1 XX DR EMBL: X14112; HE1CG(g). DR EMBL: X03141; HEHSV165(g). DR SwissProt: P06492; ATIN_HSV11. XX RN [1] RA Spector D., Purves F., Roizman B. RT Role of alpha-transducing factor (VP16) in the induction RT of alpha genes within the context of viral genomes RL J. Virol. 65:3504-3513 (1991). RN [2] RA Katan M., Haigh A., Verrijzer C. P., van der Vliet P. C., O'Hare P. RT Characterization of a cellular factor which interacts RT functionally with Oct-1 in the assembly of a multicomponent RT transcription complex RL Nucleic Acids Res. 18:6871- (1990). RN [3] RA Kristie T. M., Roizman B. RT Host cell proteins bind to the cis-acting site required RT for virion-mediated induction of herpes simplex virus 1 alpha genes RL Proc. Natl. Acad. Sci. USA 84:71-75 (1987). RN [4] RA McKnight J. L. C., Kristie T. M., Roizman B. RT Binding of the virion protein mediating alpha gene RT induction in herpes simplex virus 1-infected cells RT to its cis site requires cellular proteins RL Proc. Natl. Acad. Sci. USA 84:7061-7065 (1987). RN [5] RA Preston C. M., Frame M. C., Campbell M. E. M. RT A Complex formed between Cell Components and an HSV RT Structural Polypeptide Binds to a Viral Immediate RT Early Gene Regulatory DNA Sequence RL Cell 52:425-434 (1988). RN [6] RA Ingles C. J., Shales M., Cress W. D., Triezenberg S. J., Greenblatt J. RT Reduced binding of TFIID to transcriptionally compromised mutants of VP16 RL Nature 351:588-590 (1991). RN [7] RA Stringer K. F., Ingles C. J., Greenblatt J. RT Direct and selective binding of an acidic transcriptional RT activation domain to the TATA-box factor TFIID RL Nature 345:783-786 (1990). XX // AC T00895 XX ID T00895 XX DT 15.10.92 (created); ewi. DT 23.05.96 (updated); rkn. XX FA v-Myb XX OS AMV, avian myeloblastosis virus OC viridae; ss-RNA enveloped viruses; positive strand OC RNA viruses; retroviridae; oncovirinae; type C oncovirus OC group; avian type C oncoviruses XX CL C0022; trp; 3.5.1.1.4. XX SZ >382 AA; >43.0 kDa (gene) XX SQ NRTDVQCQHRWQKVLNPELNKGPWTKEEDQRVIEHVQKYGPKRWSDIAKHLKGRIGKQCR SQ ERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAVKNHWNSTMRR SQ KVEQEGYPQESSKAGPPSATTGFQKSSHLMAFAHNPPAGPLPGAGQAPLGSDYPYYHIAE SQ PQNVPGQIPYPVALHINIINVPQPAAAAIQRHYTDEDPEKEKRIKELELLLMSTENELKG SQ QQALPTQNHTANYPGWHSTTVADNTRTSGDNAPVSCLGEHHHCTPSPPVDHGCLPEESAS SQ PARCMIVHQSNILDNVKNLLEFAETLQLIDSFLNTSSNHENLNLDNPALTSTPVCGHKMS SQ VTTPFHKDQTFTEYRKMHGGAV XX SC SwissProt #P01104 XX FT 16 67 basic DNA-binding repeat 2 FT 24 63 tryptophan cluster (W-X19-W-X18-W) FT 68 118 basic DNA-binding repeat 3 FT 76 114 tryptophan cluster (W-X18-W-X18-W) FT 305 333 leucine zipper (MIL3) FT 215 237 acidic region (9/23) XX SF <1-15: basic DNA-binding repeat 1 SF the DNA-binding domain resides in the N-terminal part [10]; XX FF transcriptional activator [3], [7], [6]; FF oncogene, transforms myeloid and (weakly) erythroid cells [4]; FF differences between the second DNA-binding repeats FF of E26 and AMV cause different phenotypes of transformed cells [4]; FF lacks the regulatory phosphorylation site of c-Myb [2]; XX MX M00003; V$VMYB_01 MX M00227; V$VMYB_02 XX BS R01096; CHICK$MIM1_01; Quality: 2; chick, Gallus gallus BS R01097; CHICK$MIM1_02; Quality: 2; chick, Gallus gallus BS R01098; CHICK$MIM1_03; Quality: 2; chick, Gallus gallus XX DR EMBL: J02012; REONVMYB(g). DR SwissProt: P01104; MYB_AVIMB. DR PIR: A01347; QOYV. XX RN [1] RA Burk O., Mink S., Ringwald M., Klempnauer K.-H. RT Synergistic activation of the chicken mim-1 gene by RT v-myb and C/EBP transcription factors RL EMBO J. 12:2027-2038 (1993). RN [2] RA LĘscher B., Christenson E., Lichtfield D. W., Krebs E. G., Eisenman R. N. RT Myb DNA binding inhibited by phosphorylation at a RT site deleted during oncogenic activation RL Nature 344:517-522 (1990). RN [3] RA Klempnauer K.-H., Arnold H., Biedenkapp H. RT Activation of transcription by v-myb: evidence for two different mechanisms RL Genes Dev. 3:1582-1589 (1989). RN [4] RA Introna M., Golay J., Frampton J., Nakano T., Ness S. A., Graf T. RT Mutations in v-myb alter the differentiation of myelomonocytic RT cells transformed by the oncogene RL Cell 63:1287-1297 (1990). RN [5] RA Ibanez C. E., Lipsick J. S. RT Structural and functional domains of the myb oncogene: RT requirements for nuclear transport, myeloid transformation RT and colony formation RL J. Virol. 62:1981-1988 (1988). RN [6] RA Ibanez C. E., Lipsick J. S. RT Trans-activation of gene expression by v-myb RL Mol. Cell. Biol. 10:2285-2293 (1990). RN [7] RA Lane T., Ibanez C., Garcia A., Graf Th., Lipsick J. RT Transformation by v-myb Correlates with trans-Activation of Gene Expression RL Mol. Cell. Biol. 10:2591-2598 (1990). RN [8] RA Biedenkapp H., Borgmeyer U., Sippel A., Klempnauer K.-H. RT Viral myb oncogene encodes a sequence-specific DNA-binding activity RL Nature 335:835-837 (1988). RN [9] RA Kalkbrenner F., Guehmann St., Moelling K. RT Transcriptional activation by human c-myb and v-myb genes RL Oncogene 5:657-661 (1990). RN [10] RA Klempnauer K.-H., Sippel A. E. RT The highly conserved amino-terminal region of the RT protein encoded by the v-myb oncogene functions as a DNA-binding domain RL EMBO J. 6:2719-2725 (1987). RN [11] RA Bortner D. M., Ostrowski M. C. RT Analysis of the v-myb structural components important RT for transactivation of gene expression RL Nucleic Acids Res. 19:1533-1539 (1991). RN [12] RA Carr M. D., Mott R. F. RT The transcriptional control proteins c-Myb and v-Myb RT contain a basic region DNA binding motif RL FEBS Lett. 282:293-294 (1991). RN [13] RA Oehler Th., Arnold H., Biedenkapp H., Klempnauer K.-H. RT Characterization of the v-myb DNA binding domain RL Nucleic Acids Res. 18:1703-1710 (1990). XX // AC T00896 XX ID T00896 XX DT 12.03.93 (created); ewi. DT 10.01.96 (updated); hiwi. XX FA v-Myc XX OS MC29, avian myelocytomatosis virus OC Viridae; ss-RNA enveloped viruses; Positive strand OC RNA viruses; Retroviridae; Oncovirinae; Type C oncovirus OC group; Avian type C oncoviruses; Avian myelocytomatosis viruses XX CL C0012; bHLH-ZIP; 1.3.2.1.6. XX FT 1 42 transcription activation region [1]; FT 42 90 proline-rich region 1 FT 90 137 transforming region 1 [1]; FT 90 219 transcription activation region 2 [1]; FT 137 219 proline-rich region 2 FT 244 410 transforming region 2 [1]; XX SF expressed as Gag-Myc fusion protein p110(gag-may) [5]; SF mutants defective in transforming hemopoietic cells SF lack an internal region which is rich in acidic and SF phosphorylatable serine and threonine residues [6]; XX FF transcriptional activator with transforming potential XX BS R00992; AD$MLP_07; Quality: 2; adenovirus XX DR EMBL: M35624; ACMVMYC(r). DR EMBL: M35625; ACMVMYCA(r). XX RN [1] RA Min S., Taparowsky E. J. RT v-Myc, but not Max, possesses domains that function RT in both transcription activation and cellular transformation RL Oncogene 7:1531-1540 (1992). RN [2] RA Sheiness D., Fanshier L., Bishop J. M. RT - RL J. Virol. 28:600-610 (1978). RN [3] RA Lautenberger J. A., Schulz R. A., Garon C. F., Tsichlis P. N., Papas T. S. RT Molecular cloning of avian myelocytomatosis virus RT (MC29) transforming sequences RL Proc. Natl. Acad. Sci. USA 78:1518-1522 (1981). RN [4] RA Reddy E. P., Reynolds R. K., Schulz R. A., Watson RA D. K., Lautenberger J. A., Papas T. S. RT - RL Proc. Natl. Acad. Sci. USA 50:2500-2504 (1981). RN [5] RA Kitchener G., Hayman M. J. RT Comparative tryptic peptide mapping studies suggest RT a role in cell transformation for the gag-related RT protein of avian erythroblastosis virus and avian RT myelocytomatosis virus strains CMII and MC29 RL Proc. Natl. Acad. Sci. USA 77:1637-1641 (1980). RN [6] RA Bister K., Trachmann C., Jansen H. W., Schroeer B., Patschinsky T. RT Structure of mutant and wild-type MC29 v-myc alleles RT and biochemical properties of their protein products RL Oncogene 1:97-109 (1987). RN [7] RA Kerkhoff E., Bister K., Klempnauer K.-H. RT Sequence-specific DNA binding by Myc protein RL Proc. Natl. Acad. Sci. USA 88:4323-4327 (1991). XX // AC T00897 XX ID T00897 XX DT 15.10.92 (created); ewi. DT 05.11.96 (updated); ewi. XX FA v-Rel XX SY p53(v-rel); XX OS REV-T, reticuloendotheliosis virus (strain T) OC viridae; ss-RNA enveloped viruses; positive strand OC RNA viruses; retroviridae; oncovirinae; type C oncovirus OC group; mammalian type C oncoviruses XX CL C0020; Rel; 4.1.1.0.6. XX SZ 503 AA; 55.9 kDa (gene), 58-60 kDa (SDS) XX SQ MDFLTNLRFTEGISEPYIEIFEQPRQRGTRFRYKCEGRSAGSIPGEHSTDNNKTFPSIQI SQ LNYFGKVKIRTTLVTKNEPYKPHPHDLVGKGCRDGYYEAEFGPERQVLSFQNLGIQCVKK SQ KDLKESISLRISKKINPFNVPEEQLHNIDEYDLNVVRLCFQAFLPDEHGNYTLALPPLIS SQ NPIYDNRAPNTAELRICRVNKNCGSVKGGDEIFLLCDKVQKDDIEVRFVLGNWEAKGSFS SQ QADVHRQVAIVFRTPPFLGDITEPITVKMQLRRPSDQAVSEPVDFRYLPDEEDPSGNKAK SQ RQRSTLAWQKPIQDCGSAVTERPKAAPIPTVNPEGKLKKEPNMFSPTLMLPGLGTLSSSQ SQ MYPACSQMPTQPAQLGPGKQDTLHSCWQQLYSPSPSASSLLSLHSHSSFTAEVPQPGAQG SQ SSSLPAYNPLNWPDEKNSSFYRNFGNTHGMGAALVSAAGMQSVSSSSIVQGTHQASATTA SQ SIMTMPRTPGEVPFLRQQVGYRS XX SC SwissProt #P01126 XX FT 16 303 Rel homology region FT 27 35 essential for IkappaB-alpha binding [11]; XX SF lacking the strong trans-activation domain found in c-Rel [7]; SF the IkappaB-contacting motif RXXRXRXXC is highly conserved SF among Rel-like factors and is part of the DNA-binding SF loop 1 in NF-kappaB1 (p50) [11]; SF C-terinally adjacent to the Rel domain is a trans-activating SF domain which is active in undifferentiated cells only [5], [13]; SF it interacts directly with TBP [8]; SF interaction with IkappaB-alpha and -beta does not SF prevent DNA-binding [1], [9]; XX FF competitively inhibits NF-kappaB and c-Rel to activate FF kappaB sites [17], [10], [6]; FF in contrast to c-rel, v-Rel enhances the activating effect of Sp1 [12]; XX IN T00168; c-Rel; human, Homo sapiens. IN T00169; c-Rel; mouse, Mus musculus. IN T00416; IkappaB-beta; chick, Gallus gallus. IN T00587; NF-kappaB; rat, Rattus norvegicus. IN T00588; NF-kappaB; mouse, Mus musculus. IN T00590; NF-kappaB; human, Homo sapiens. IN T00593; NF-kappaB1; human, Homo sapiens. IN T00594; RelA; human, Homo sapiens. IN T00595; RelA; mouse, Mus musculus. IN T00794; TBP; human, Homo sapiens. IN T00796; TBP; mouse, Mus musculus. IN T00897; v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00950; IkappaB-alpha; human, Homo sapiens. IN T00971; IkappaB-beta; mouse, Mus musculus. IN T01154; c-Rel; chick, Gallus gallus. IN T01923; NF-kappaB1; mouse, Mus musculus. IN T01924; NF-kappaB1 precursor; mouse, Mus musculus. IN T01925; NF-kappaB1 precursor; human, Homo sapiens. IN T01937; IkappaB-alpha; chick, Gallus gallus. XX BS R01748; AS$NFKB_01; Quality: 1 BS R02668; AS$NFKB_02; Quality: 6 BS R01058; MOUSE$M1H2KB_06; Quality: 6; mouse, Mus musculus XX DR EMBL: K00555; ACRREL(g). DR SwissProt: P01126; REL_AVIRE. DR PIR: A01378; VCVDA. XX RN [1] RA Kerr L. D., Inoue J.-I., Davis N., Link E., Baeuerle RA P. A., Bose H. R., jr. -, Verma I. M. RT The Rel-associated pp40 protein prevents DNA binding RT of Rel and NF-kappaB: relationship with IkappaBbeta RT and regulation by phosphorylation RL Genes Dev. 5:1464-1476 (1991). RN [2] RA Ballard D. W., Walker W. H., Doerre S., Sista P., RA Molitor J. A., Dixon E. P., Peffer N. J., Hannink M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding RT protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). RN [3] RA Wilhelmsen K. C., Eggleton K., Temin H. M. RT Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis RT virus strain T and its cellular homolog, the proto-oncogene c-rel RL J. Virol. 52:172-182 (1984). RN [4] RA Stephens R. M., Rice N. R., Hiebsch R. R., Bose H. R., Gilden R. V. RT Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus RL Proc. Natl. Acad. Sci. USA 80:6229-6233 (1983). RN [5] RA Sarkon S., Gilmore T. D. RT Transformation by the v-rel oncoprotein requires sequences RT carboxy-terminal to the rel homology domain RL Oncogene 8:2245-2252 (1993). RN [6] RA Ballard D. W., Dixon E. P., Peffer N. J., Bogerd H., RA Doerre S., Stein B., Greene W. C. RT The 65-kDa subunit of human NF-kappaB functions as RT a potent transcriptional activator and a target for RT v-Rel-mediated repression RL Proc. Natl. Acad. Sci. USA 89:1875-1879 (1992). RN [7] RA Richardson P. M., Gilmore T. D. RT vRel is an inactive member of the Rel family of transcriptional RT activating proteins RL J. Virol. 65:3122-3130 (1991). RN [8] RA Xu X., Prorock C., Ishikawa H., Maldonado E., Ito Y., GJlinas C. RT Functional interaction of the v-Rel and c-Rel oncoproteins RT with the TATA-binding protein and association with transcription factor IIB RL Mol. Cell. Biol. 13:6733-6741 (1993). RN [9] RA Diehl A., McKinsey T. A., Hannink M. RT Differential pp40IkappaB-beta inhibition of DNA binding by rel proteins RL Mol. Cell. Biol. 13:1769-1778 (1993). RN [10] RA McDonnell P. C., Kumar S., Rabson A. B., GJlinas C. RT Transcriptional activity of rel family proteins RL Oncogene 7:163-170 (1992). RN [11] RA Kumar S., GJlinas C. RT IkappaBalpha-mediated inhibition of v-Rel DNA binding RT requires direct interaction with the RXXRXRXXC Rel/kappaB DNA-binding motif RL Proc. Natl. Acad. Sci. USA 90:8962-8966 (1993). RN [12] RA Sif S., Capobianco A. J., Gilmore T. D. RT The v-Rel oncoprotein increases expression from Sp1 RT site-containing promoters in chicken embryo fibroblasts RL Oncogene 8:2501-2509 (1993). RN [13] RA Walker W. H., Stein B., Ganchi P. A., Hoffman J. A., RA Kaufman P. A., Ballard D. W., Hannink M., Greene W. C. RT The v-rel oncogene: insights into the mechanism of RT transcriptional activation, repression, and transformation RL J. Virol. 66:5018-5029 (1992). RN [14] RA Kabrun N., Hodgson J. W., Doemer M., Mak G., Franza RA B. R., jr. -, Enrietto P. J. RT Interaction of the v-rel protein with an NF-kappaB DNA binding site RL Proc. Natl. Acad. Sci. USA 88:1783-1787 (1991). RN [15] RA Inoue J.-I., Kerr L. D., Ransone L. J., Bengal E., Hunter T., Verma I. M. RT c-rel activates but v-rel suppresses transcription from kappaB sites RL Proc. Natl. Acad. Sci. USA 88:3715-3719 (1991). RN [16] RA Logeat F., Israel N., Ten R., Blank V., Le Bail O., Kourilsky P., Israel A. RT Inhibition of transcription factors belonging to the RT rel/NF-kappaB family by a transdominant negative mutant RL EMBO J. 10:1827-1832 (1991). RN [17] RA Ballard D. W., Walker W. H., Doerre S., Sista P., RA Molitor J. A., Dixon E. P., Peffer N. J., Hannik M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding RT protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). XX // AC T00899 XX ID T00899 XX DT 10.11.92 (created); ewi. DT 05.06.96 (updated); ewi. XX FA WT1 XX SY WT-ZFP; WT1 +KTS; Wilms tumor